Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02963
(857 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G) 136 9e-32
sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DA... 132 1e-30
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 130 6e-30
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 130 6e-30
sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DA... 128 2e-29
sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) ... 122 1e-27
sp|O89019|INVS_MOUSE Inversin (Inversion of embryo turning ... 111 3e-24
sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4... 111 3e-24
sp|O15084|ANR28_HUMAN Ankyrin repeat domain protein 28 110 4e-24
sp|Q9ULJ7|YB23_HUMAN Hypothetical protein KIAA1223 110 4e-24
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
Length = 4377
Score = 136 bits (342), Expect = 9e-32
Identities = 67/243 (27%), Positives = 128/243 (52%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQI-IDILNSAAYPW-----GNQ 165
K G +++ +L+ +A K G +P+ +A +Q++ + +L+ A P G
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + +DIA TL+ D N G +HLA G++D+V +L+ ++N S
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLS 693
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
+K G P+H A + +++ ++L++ ++ +K GY +H+ C +G+I IV L+
Sbjct: 694 NKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHS 753
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
+NA GY P+H A ++GH I+ +L++N + LT G + + IA++ + +++
Sbjct: 754 AKVNAKTK-NGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 812
Query: 706 DIL 714
D L
Sbjct: 813 DTL 815
Score = 116 bits (291), Expect = 7e-26
Identities = 65/276 (23%), Positives = 130/276 (47%), Gaps = 38/276 (13%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIID-ILNSAAYP-----WGN 162
CK I ++++L+ + I A+T+ G +PI +A H I+ +++ A P G
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE 467
Query: 163 QQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINA 342
LH + +G ++ + L+ + + + P+H++ G DIV+ L+ NA
Sbjct: 468 TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Query: 343 SDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIAR 522
+ GY P+H + R GH D+ L+D+ +++ +K G+ +H+A +G +++ +L+ +
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Query: 523 KCDINAS--------------DNWM------------------GYQPIHFACEKGHIDIV 606
+A+ DN GY P+H A +K +DI
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647
Query: 607 KLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDIL 714
L+E +A ++T+ G +++ +A Q H ++ +L
Sbjct: 648 TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 115 bits (287), Expect = 2e-25
Identities = 70/273 (25%), Positives = 118/273 (43%), Gaps = 38/273 (13%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILN------SAAYPWGNQQL 171
G DIV+ L+ NA T G +P+ ++ + H+ + L S G L
Sbjct: 510 GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPL 569
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
H + G +++A L+ + + G P+H+A + +L+D +A+ K
Sbjct: 570 HVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAK 629
Query: 352 IGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCD 531
GY P+H A + +DI L++ D N ++ G S+HLA GH+D+V +L+ R +
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 532 INASD--------------------------------NWMGYQPIHFACEKGHIDIVKLL 615
+N S+ MGY P+H C G+I IV L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 616 IENKCNAKSLTKYGQSTIDIAKQNRHQTIIDIL 714
+++ + TK G + + A Q H II++L
Sbjct: 750 LQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 107 bits (268), Expect = 3e-23
Identities = 56/231 (24%), Positives = 116/231 (50%), Gaps = 6/231 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPW------GNQ 165
K G+ ++VK+L+D I+A T++G +P+ H+Q++++L A P G
Sbjct: 277 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + +++ + L+ + ++ +H+A G+ + K+L+D K + NA
Sbjct: 337 PLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAK 396
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
G+ P+H AC+ I ++++L+ + I ++ G +H+A GH++IV L+
Sbjct: 397 ALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHG 456
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIA 678
N + N G +H A G ++V+ L+++ ++ K Q+ + I+
Sbjct: 457 ASPNTT-NVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHIS 506
Score = 107 bits (267), Expect = 4e-23
Identities = 57/239 (23%), Positives = 120/239 (50%), Gaps = 2/239 (0%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL--NSAAYPWGNQQLHY 177
+ H+++VK L+DN + T++G +P+ +A ++ H Q++ +L N LH
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHI 208
Query: 178 SCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIG 357
+ + A L+ N + + + G+ P+H+A G I++ +L++ ++ + +
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 358 YQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDIN 537
P+H A + G+ ++VK+L+D I+ ++DG +H GH +V++L+ R I
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI- 327
Query: 538 ASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDIL 714
S G P+H A + H++ V+LL+++ +T + + +A H + +L
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 107 bits (266), Expect = 6e-23
Identities = 67/309 (21%), Positives = 145/309 (46%), Gaps = 38/309 (12%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNS------AAYPWGNQQL 171
GH++ I N DIN + G + + +A ++ H +++ L AA GN L
Sbjct: 52 GHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTAL 111
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
H + G ++ K L+ N ++N + G+ P+++A ++++VK L+DN + + +
Sbjct: 112 HIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATE 171
Query: 352 IGYQPIHFACRNGHIDIVKILIDNKC-----------------------------DINVF 444
G+ P+ A + GH +V +L++N + +V
Sbjct: 172 DGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVE 231
Query: 445 SKDGYQSMHLACMFGHIDIVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIEN 624
SK G+ +H+A +G+I++ +L+ R ++ + P+H A ++G+ ++VKLL++
Sbjct: 232 SKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR-NDITPLHVASKRGNANMVKLLLDR 290
Query: 625 KCNAKSLTKYGQSTIDIAKQNRHQTIIDIL--NSSDQIESIVKALN-LQCSINCDHKFCR 795
+ T+ G + + ++ H+ ++++L ++ + L+ L + DH C
Sbjct: 291 GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCV 350
Query: 796 ETLNKDKLP 822
+ L + +P
Sbjct: 351 QLLLQHNVP 359
Score = 101 bits (252), Expect = 2e-21
Identities = 56/241 (23%), Positives = 118/241 (48%), Gaps = 7/241 (2%)
Frame = +1
Query: 13 HIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-------NSAAYPWGNQQL 171
H++ V++L+ + ++ +T + + + +A H ++ +L N+ A G L
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN-GFTPL 404
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
H +C + + + L+ + I E G PIH+A G+++IV L+ + N ++
Sbjct: 405 HIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNV 464
Query: 352 IGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCD 531
G +H A R+G ++V+ L+ + + +KD +H++ G DIV+ L+ +
Sbjct: 465 RGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS 524
Query: 532 INASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDI 711
NA+ GY P+H + +GH D+ L+++ + TK G + + +A + + ++
Sbjct: 525 PNAATT-SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 712 L 714
L
Sbjct: 584 L 584
Score = 90.5 bits (223), Expect = 5e-18
Identities = 39/150 (26%), Positives = 84/150 (56%)
Frame = +1
Query: 277 ACMRGYIDIVKILIDNKCDINASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDG 456
A G+++ I N DIN ++ G +H A + GH+++V L+ + +++ +K G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 457 YQSMHLACMFGHIDIVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNA 636
++H+A + G ++VK+L+ ++NA G+ P++ A ++ H+++VK L++N +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQ-NGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 637 KSLTKYGQSTIDIAKQNRHQTIIDILNSSD 726
T+ G + + +A Q H ++ +L +D
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLEND 196
>sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DAP kinase 1)
Length = 1442
Score = 132 bits (332), Expect = 1e-30
Identities = 73/243 (30%), Positives = 128/243 (52%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQQ----- 168
++GH+D +K L +NKC ++ K GE+ + +A H ++ +L S Q
Sbjct: 421 RHGHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEET 480
Query: 169 -LHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + +G +AK L C++N + G P+ A RGY DIV+ L ++ D+NAS
Sbjct: 481 PLHCAAWHGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNAS 540
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
DK G+ +H A R ++++K L+ + ++ + G +H+AC G IV L
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEAS 600
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
C+++ S+ + G P+H A G +D+V+ L N ++LT G++ D+AK +H+ +
Sbjct: 601 CNLDISNKY-GRTPLHLAANNGILDVVRYLCLMGANVEALTSDGKTAEDLAKAEQHEHVA 659
Query: 706 DIL 714
+L
Sbjct: 660 GLL 662
Score = 96.7 bits (239), Expect = 7e-20
Identities = 70/272 (25%), Positives = 122/272 (44%), Gaps = 38/272 (13%)
Frame = +1
Query: 52 DINALTKEGESPIDIAREKKHQQIIDILNSAAY------PWGNQQLHYSCNNGNVDIAKT 213
D+N K G P+ IA + Q++ +L G+ ++++ +G+VD K
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGHVDTLKF 430
Query: 214 LIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGYQPIHFACRNGH 393
L NKC ++ D+ G +H+A G+ D+V++L + + DK P+H A +G+
Sbjct: 431 LNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGY 490
Query: 394 IDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDINASD--------- 546
+ K L + C++N+ +++G + A G+ DIV+ L D+NASD
Sbjct: 491 YSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNASDKDGHIALHL 550
Query: 547 -----------------------NWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYG 657
+ G P+H AC+ G IV L E CN KYG
Sbjct: 551 AVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISNKYG 610
Query: 658 QSTIDIAKQNRHQTIIDILNSSDQIESIVKAL 753
++ + +A N I+D++ + + V+AL
Sbjct: 611 RTPLHLAANN---GILDVVRYLCLMGANVEAL 639
Score = 83.6 bits (205), Expect = 7e-16
Identities = 48/181 (26%), Positives = 90/181 (49%), Gaps = 6/181 (3%)
Frame = +1
Query: 7 NGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILN------SAAYPWGNQQ 168
+G+ + K L + C++N +EGE+P+ A + + I++ L +A+ G+
Sbjct: 488 HGYYSVAKALCEVGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNASDKDGHIA 547
Query: 169 LHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASD 348
LH + +++ KTL+ + ++ D G P+H+AC G IV L + C+++ S+
Sbjct: 548 LHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISN 607
Query: 349 KIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKC 528
K G P+H A NG +D+V+ L ++ + DG + LA H + +L +
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGANVEALTSDGKTAEDLAKAEQHEHVAGLLARLRK 667
Query: 529 D 531
D
Sbjct: 668 D 668
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 130 bits (326), Expect = 6e-30
Identities = 69/254 (27%), Positives = 135/254 (53%), Gaps = 7/254 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-------NSAAYPWGN 162
K G + + ++L+++ NA K G +P+ +A + I+ +L +S A+ G
Sbjct: 541 KYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GY 599
Query: 163 QQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINA 342
LH + +++A++L+ N G P+HLA G+ ++V +L+ + + N
Sbjct: 600 TPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNL 659
Query: 343 SDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIAR 522
+K G P+H + GH+ + +LI + ++ ++ GY +H+A +G+I +VK L+
Sbjct: 660 GNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQH 719
Query: 523 KCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTI 702
+ D+NA +GY P+H A ++GH DIV LL++N + ++ G + + IAK+ + ++
Sbjct: 720 QADVNAKTK-LGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISV 778
Query: 703 IDILNSSDQIESIV 744
D+L S+V
Sbjct: 779 TDVLKVVTDETSVV 792
Score = 119 bits (298), Expect = 1e-26
Identities = 67/245 (27%), Positives = 119/245 (48%), Gaps = 7/245 (2%)
Frame = +1
Query: 13 HIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-------NSAAYPWGNQQL 171
H+D V++L+ +I+ +T + +P+ +A H ++ +L NS A G L
Sbjct: 313 HLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-GFTPL 371
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
H +C ++ + + L+ I+ E G P+H+A G++ IVK L+ N S+
Sbjct: 372 HIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 431
Query: 352 IGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCD 531
P+H A R GH ++ K L+ NK N +KD +H A GH +VK+L+
Sbjct: 432 KVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGAS 491
Query: 532 INASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDI 711
N + G+ P+H A +GH+D L+E + + +TK G + + +A + + ++
Sbjct: 492 PNLATT-AGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAEL 550
Query: 712 LNSSD 726
L D
Sbjct: 551 LLEHD 555
Score = 115 bits (289), Expect = 1e-25
Identities = 69/245 (28%), Positives = 124/245 (50%), Gaps = 7/245 (2%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQII-DILNSAAYPWGNQ---- 165
CK HI ++++L+ I+A+T+ G +P+ +A H I+ ++L A P +
Sbjct: 375 CKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 434
Query: 166 -QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINA 342
LH + G+ ++AK L+ NK N + P+H A G+ +VK+L++N N
Sbjct: 435 TPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNL 494
Query: 343 SDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIAR 522
+ G+ P+H A R GH+D L++ + +K G+ +H+A +G + + ++L+
Sbjct: 495 ATTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEH 554
Query: 523 KCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDI-AKQNRHQT 699
NA+ G P+H A ++DIVKLL+ + S G + + I AKQN+ +
Sbjct: 555 DAHPNAAGK-NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEV 613
Query: 700 IIDIL 714
+L
Sbjct: 614 ARSLL 618
Score = 114 bits (285), Expect = 3e-25
Identities = 64/243 (26%), Positives = 118/243 (48%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPW------GNQ 165
+ G++ +V++L+D I TK+ +P+ A H +I +IL P G
Sbjct: 244 RRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 303
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
+H + ++D + L+ +I+ P+H+A G+ + K+L+D N+
Sbjct: 304 PIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 363
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
G+ P+H AC+ HI ++++L+ I+ ++ G +H+A GH+ IVK L+ R
Sbjct: 364 ALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 423
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
N S N P+H A GH ++ K L++NK A + K Q+ + A + H ++
Sbjct: 424 ASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHTGMV 482
Query: 706 DIL 714
+L
Sbjct: 483 KLL 485
Score = 110 bits (276), Expect = 4e-24
Identities = 60/243 (24%), Positives = 122/243 (50%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQ------ 165
+ H+++VK L++N + N T++G +P+ +A ++ H+ ++ L + +G +
Sbjct: 116 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN----YGTKGKVRLP 171
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + N + A L+ N + + + G+ P+H+A +++ ++L++ +N +
Sbjct: 172 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 231
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
+ G P+H A R G++ +V++L+D I +KD +H A GH+ I +IL+
Sbjct: 232 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHG 291
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
I A G PIH A + H+D V+LL++ +T + + +A H +
Sbjct: 292 APIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVA 350
Query: 706 DIL 714
+L
Sbjct: 351 KVL 353
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/243 (23%), Positives = 122/243 (50%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQII-DILN-----SAAYPWGNQ 165
K GH+ +V L+ + + TK+G + + IA +++ +++N +A G
Sbjct: 50 KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 109
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
L+ + ++++ K L+ N + N E G+ P+ +A +G+ ++V LI +
Sbjct: 110 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 165
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
K+ +H A RN +L+ N + +V SK G+ +H+A + ++++ ++L+ R
Sbjct: 166 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 225
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
+N + G P+H A +G++ +V+LL++ ++ TK + + A +N H I
Sbjct: 226 ASVNFTPQ-NGITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRIS 284
Query: 706 DIL 714
+IL
Sbjct: 285 EIL 287
Score = 79.0 bits (193), Expect = 2e-14
Identities = 41/147 (27%), Positives = 80/147 (54%)
Frame = +1
Query: 178 SCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIG 357
+ +GN+D A + N DINTC++ G +HLA G++ +V L+ + + + K G
Sbjct: 15 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 74
Query: 358 YQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDIN 537
+H A G ++V+ L++ ++N S+ G+ +++A H+++VK L+ + N
Sbjct: 75 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 134
Query: 538 ASDNWMGYQPIHFACEKGHIDIVKLLI 618
+ G+ P+ A ++GH ++V LI
Sbjct: 135 VATE-DGFTPLAVALQQGHENVVAHLI 160
Score = 77.8 bits (190), Expect = 4e-14
Identities = 44/186 (23%), Positives = 91/186 (48%)
Frame = +1
Query: 157 GNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDI 336
G LH + G+V + L+ + + T + G +H+A + G ++V+ L++ ++
Sbjct: 41 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 100
Query: 337 NASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILI 516
NA + G+ P++ A + H+++VK L++N + NV ++DG+ + +A GH ++V LI
Sbjct: 101 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 160
Query: 517 ARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQ 696
+ + +H A +L++N N L+K G + + IA +
Sbjct: 161 N-----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 215
Query: 697 TIIDIL 714
+ +L
Sbjct: 216 NVAQLL 221
Score = 32.0 bits (71), Expect = 2.3
Identities = 21/76 (27%), Positives = 35/76 (46%)
Frame = +1
Query: 451 DGYQSMHLACMFGHIDIVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKC 630
D S A G++D + DIN N G +H A ++GH+ +V L+ +
Sbjct: 7 DAATSFLRAARSGNLDKALDHLRNGVDINTC-NQNGLNGLHLASKEGHVKMVVELLHKEI 65
Query: 631 NAKSLTKYGQSTIDIA 678
++ TK G + + IA
Sbjct: 66 ILETTTKKGNTALHIA 81
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 130 bits (326), Expect = 6e-30
Identities = 68/244 (27%), Positives = 131/244 (53%), Gaps = 7/244 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-------NSAAYPWGN 162
K G + + ++L++ NA K G +P+ +A + I+ +L +S A+ G
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GY 603
Query: 163 QQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINA 342
LH + V++A++L+ N G P+HLA G+ ++V +L+ + + N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 343 SDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIAR 522
+K G P+H + GH+ + +LI + ++ ++ GY +H+A +G+I +VK L+
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 523 KCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTI 702
+ D+NA +GY P+H A ++GH DIV LL++N + ++ G + + IAK+ + ++
Sbjct: 724 QADVNAKTK-LGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 703 IDIL 714
D+L
Sbjct: 783 TDVL 786
Score = 124 bits (310), Expect = 4e-28
Identities = 68/245 (27%), Positives = 123/245 (50%), Gaps = 7/245 (2%)
Frame = +1
Query: 13 HIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-------NSAAYPWGNQQL 171
H+D V++L+ +I+ +T + +P+ +A H ++ +L NS A G L
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN-GFTPL 375
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
H +C +V + + L+ I+ E G P+H+A G++ IVK L+ N S+
Sbjct: 376 HIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNV 435
Query: 352 IGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCD 531
P+H A R GH ++ K L+ NK +N +KD +H A GH ++VK+L+ +
Sbjct: 436 KVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNAN 495
Query: 532 INASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDI 711
N + G+ P+H A +GH++ V L+E + + +TK G + + +A + + ++
Sbjct: 496 PNLATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAEL 554
Query: 712 LNSSD 726
L D
Sbjct: 555 LLERD 559
Score = 122 bits (305), Expect = 2e-27
Identities = 69/245 (28%), Positives = 129/245 (52%), Gaps = 7/245 (2%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQII-DILNSAAYPWGNQ---- 165
CK H+ ++++L+ I+A+T+ G +P+ +A H I+ ++L A P +
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE 438
Query: 166 -QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINA 342
LH + G+ ++AK L+ NK +N + P+H A G+ ++VK+L++N + N
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 343 SDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIAR 522
+ G+ P+H A R GH++ V L++ + +K G+ +H+A +G + + ++L+ R
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLER 558
Query: 523 KCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDI-AKQNRHQT 699
NA+ G P+H A ++DIVKLL+ + S G + + I AKQN+ +
Sbjct: 559 DAHPNAAGK-NGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEV 617
Query: 700 IIDIL 714
+L
Sbjct: 618 ARSLL 622
Score = 112 bits (281), Expect = 1e-24
Identities = 62/243 (25%), Positives = 117/243 (48%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPW------GNQ 165
+ G++ +V++L+D I TK+ +P+ A H +I +IL P G
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
+H + ++D + L+ +I+ P+H+A G+ + K+L+D N+
Sbjct: 308 PIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 367
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
G+ P+H AC+ H+ ++++L+ I+ ++ G +H+A GH+ IVK L+ R
Sbjct: 368 ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
N S N P+H A GH ++ K L++NK + K Q+ + A + H ++
Sbjct: 428 ASPNVS-NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMV 486
Query: 706 DIL 714
+L
Sbjct: 487 KLL 489
Score = 110 bits (275), Expect = 5e-24
Identities = 60/243 (24%), Positives = 122/243 (50%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQ------ 165
+ H+++VK L++N + N T++G +P+ +A ++ H+ ++ L + +G +
Sbjct: 120 QENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN----YGTKGKVRLP 175
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + N + A L+ N + + + G+ P+H+A +++ ++L++ +N +
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
+ G P+H A R G++ +V++L+D I +KD +H A GH+ I +IL+
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
I A G PIH A + H+D V+LL++ +T + + +A H +
Sbjct: 296 APIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 706 DIL 714
+L
Sbjct: 355 KVL 357
Score = 94.7 bits (234), Expect = 3e-19
Identities = 58/243 (23%), Positives = 122/243 (50%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQII-DILN-----SAAYPWGNQ 165
K GH+ +V L+ + + TK+G + + IA +++ +++N +A G
Sbjct: 54 KEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT 113
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
L+ + ++++ K L+ N + N E G+ P+ +A +G+ ++V LI +
Sbjct: 114 PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI----NYGTK 169
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
K+ +H A RN +L+ N + +V SK G+ +H+A + ++++ ++L+ R
Sbjct: 170 GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRG 229
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
+N + G P+H A +G++ +V+LL++ ++ TK + + A +N H I
Sbjct: 230 ASVNFTPQ-NGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 706 DIL 714
+IL
Sbjct: 289 EIL 291
Score = 79.0 bits (193), Expect = 2e-14
Identities = 41/147 (27%), Positives = 80/147 (54%)
Frame = +1
Query: 178 SCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIG 357
+ +GN+D A + N DINTC++ G +HLA G++ +V L+ + + + K G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 358 YQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDIN 537
+H A G ++V+ L++ ++N S+ G+ +++A H+++VK L+ + N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138
Query: 538 ASDNWMGYQPIHFACEKGHIDIVKLLI 618
+ G+ P+ A ++GH ++V LI
Sbjct: 139 VATE-DGFTPLAVALQQGHENVVAHLI 164
Score = 77.8 bits (190), Expect = 4e-14
Identities = 44/186 (23%), Positives = 91/186 (48%)
Frame = +1
Query: 157 GNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDI 336
G LH + G+V + L+ + + T + G +H+A + G ++V+ L++ ++
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 337 NASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILI 516
NA + G+ P++ A + H+++VK L++N + NV ++DG+ + +A GH ++V LI
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 517 ARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQ 696
+ + +H A +L++N N L+K G + + IA +
Sbjct: 165 N-----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 697 TIIDIL 714
+ +L
Sbjct: 220 NVAQLL 225
Score = 32.0 bits (71), Expect = 2.3
Identities = 21/76 (27%), Positives = 35/76 (46%)
Frame = +1
Query: 451 DGYQSMHLACMFGHIDIVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKC 630
D S A G++D + DIN N G +H A ++GH+ +V L+ +
Sbjct: 11 DAATSFLRAARSGNLDKALDHLRNGVDINTC-NQNGLNGLHLASKEGHVKMVVELLHKEI 69
Query: 631 NAKSLTKYGQSTIDIA 678
++ TK G + + IA
Sbjct: 70 ILETTTKKGNTALHIA 85
>sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1)
Length = 1432
Score = 128 bits (322), Expect = 2e-29
Identities = 68/245 (27%), Positives = 126/245 (51%), Gaps = 8/245 (3%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWG-------- 159
++GH+D +K L +NKC ++ K GE + +A H + + ++
Sbjct: 421 RHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEE 480
Query: 160 NQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDIN 339
LH + +G +AK L C++N + G P+ A RGY DIV+ L ++ D+N
Sbjct: 481 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLN 540
Query: 340 ASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIA 519
A DK G+ +H A R ++++K L+ C ++ + G +H+AC G++ IV L
Sbjct: 541 ACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCE 600
Query: 520 RKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQT 699
C+++ S+ + G P+H A G +D+V+ L + ++LT G++ D+A+ +H+
Sbjct: 601 ANCNLDISNKY-GRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEH 659
Query: 700 IIDIL 714
+ +L
Sbjct: 660 VAGLL 664
Score = 92.8 bits (229), Expect = 1e-18
Identities = 51/185 (27%), Positives = 97/185 (52%), Gaps = 5/185 (2%)
Frame = +1
Query: 175 YSCNNGNVDIAKTLI--VNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASD 348
++ N+ NV + L+ ++ D+N ++ G P+ +A G I I+++LI I+ D
Sbjct: 350 HAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQD 409
Query: 349 KIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKC 528
K G +++A R+GH+D +K L +NKC ++V K G ++H+A +GH D+ ++ + C
Sbjct: 410 KGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVL--C 467
Query: 529 DINASDNWMGYQ---PIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQT 699
++ N + P+H A G+ + K L E CN + G++ + A +
Sbjct: 468 SFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHD 527
Query: 700 IIDIL 714
I++ L
Sbjct: 528 IVECL 532
Score = 88.2 bits (217), Expect = 3e-17
Identities = 54/190 (28%), Positives = 90/190 (47%), Gaps = 2/190 (1%)
Frame = +1
Query: 157 GNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDI 336
G L + GN+ I + LI I+ D+ G ++ A G++D +K L +NKC +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 337 NASDKIGYQPIHFACRNGHIDI--VKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKI 510
+ DK G +H A R GH D+ V++L + N+ K+ +H A G+ + K
Sbjct: 439 DVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKA 498
Query: 511 LIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNR 690
L C++N N G P+ A +G+ DIV+ L E+ + + K G + +A +
Sbjct: 499 LCEAGCNVNIK-NREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRC 557
Query: 691 HQTIIDILNS 720
+I L S
Sbjct: 558 QMEVIKTLLS 567
Score = 87.4 bits (215), Expect = 5e-17
Identities = 49/181 (27%), Positives = 89/181 (49%), Gaps = 6/181 (3%)
Frame = +1
Query: 7 NGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILN------SAAYPWGNQQ 168
+G+ + K L + C++N +EGE+P+ A + + I++ L +A G+
Sbjct: 490 HGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIA 549
Query: 169 LHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASD 348
LH + +++ KTL+ C ++ D G P+H+AC G + IV L + C+++ S+
Sbjct: 550 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 609
Query: 349 KIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKC 528
K G P+H A NG +D+V+ L + + DG + LA H + +L +
Sbjct: 610 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRK 669
Query: 529 D 531
D
Sbjct: 670 D 670
>sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
Length = 3924
Score = 122 bits (307), Expect = 1e-27
Identities = 66/243 (27%), Positives = 127/243 (52%), Gaps = 6/243 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQI-IDILNSAAYPW-----GNQ 165
K G +D+ K+L+ + ++ K G +P+ +A +Q++ + +L A P G
Sbjct: 572 KYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYT 631
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + + IA TL+ + N + G P+HLA G+ D+V +L+D +I+ S
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMS 691
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
K G +H A + +++ IL + D + +K GY + +AC +G++ +V L+ +
Sbjct: 692 TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQG 751
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
++NA GY P+H A ++GH I+ +L+++ + T G + + IAK+ + +++
Sbjct: 752 ANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 706 DIL 714
D L
Sbjct: 811 DTL 813
Score = 112 bits (279), Expect = 2e-24
Identities = 65/256 (25%), Positives = 128/256 (50%), Gaps = 7/256 (2%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-NSAAYP-----WGN 162
CK I ++++L+ I A+T+ G +PI +A H I+ +L + A P G
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGE 465
Query: 163 QQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINA 342
LH + G V++ + L+ N ++ P+H+A G +IV++L+ + +A
Sbjct: 466 TALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 343 SDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIAR 522
+ GY P+H + R G +D+ +L++ ++ +K G+ +H+A +G +D+ K+L+ R
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 523 KCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDI-AKQNRHQT 699
+ +++ G P+H A + + LL+E + + K G + + I AK+N+ Q
Sbjct: 586 RAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 700 IIDILNSSDQIESIVK 747
+LN + + K
Sbjct: 645 ASTLLNYGAETNIVTK 660
Score = 109 bits (273), Expect = 9e-24
Identities = 63/247 (25%), Positives = 123/247 (49%), Gaps = 10/247 (4%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL--NSAAYPWGNQQLHY 177
+ HID+VK L++N + + T++G +P+ +A ++ H Q + IL N LH
Sbjct: 139 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHI 198
Query: 178 SCNNGNVDIAKTLIVN--------KCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCD 333
+ + A L+ N K +N E G+ P+H+A G +++ +L++
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258
Query: 334 INASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKIL 513
++ + + G P+H A + G+ ++VK+L+D I+ ++DG +H A GH +V++L
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Query: 514 IARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRH 693
+ R + A G P+H A + H++ VK L+++K +T + + +A H
Sbjct: 319 LERGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGH 377
Query: 694 QTIIDIL 714
+ +L
Sbjct: 378 YRVTKLL 384
Score = 103 bits (257), Expect = 6e-22
Identities = 66/273 (24%), Positives = 124/273 (45%), Gaps = 38/273 (13%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL------NSAAYPWGNQQL 171
G +IV++L+ + +A T G +P+ I+ + + +L +S A G L
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
H + G++D+AK L+ + ++ + G P+H+A + +L++ +A+ K
Sbjct: 568 HVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAK 627
Query: 352 IGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILI----- 516
GY P+H A + + I L++ + N+ +K G +HLA GH D+V +L+
Sbjct: 628 NGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Query: 517 ---------------ARKCDINASD------------NWMGYQPIHFACEKGHIDIVKLL 615
A++ +N +D +GY P+ AC G++ +V L
Sbjct: 688 IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFL 747
Query: 616 IENKCNAKSLTKYGQSTIDIAKQNRHQTIIDIL 714
++ N + TK G + + A Q H II++L
Sbjct: 748 LKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Score = 102 bits (254), Expect = 1e-21
Identities = 61/252 (24%), Positives = 124/252 (49%), Gaps = 6/252 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGN------Q 165
++GH +V++L++ + A TK G SP+ +A + H + + L P +
Sbjct: 308 RSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLT 367
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + + G+ + K L+ + + N G+ P+H+AC + I ++++L+ I A
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
+ G PIH A GH++IV +L+ N +V + G ++H+A G +++V+ L+
Sbjct: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
++A P+H A G +IV+LL+++ + + T G + + I+ + +
Sbjct: 488 ALVDARAR-EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
Query: 706 DILNSSDQIESI 741
+L + S+
Sbjct: 547 SVLLEAGAAHSL 558
Score = 96.7 bits (239), Expect = 7e-20
Identities = 63/273 (23%), Positives = 125/273 (45%), Gaps = 43/273 (15%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL------NSAAYPWGNQ 165
K GH+ +V+ L+ +++ TK+G + + IA +++ +L +A G
Sbjct: 73 KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDN------- 324
L+ + ++D+ K L+ N + +T E G+ P+ +A +G+ V IL++N
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 325 ------------------------------KCDINASDKIGYQPIHFACRNGHIDIVKIL 414
K +N + + G+ P+H A G++++ +L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 415 IDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDINASDNWMGYQPIHFACEKGH 594
++ ++ +++G +H+A G+ ++VK+L+ R I+A G P+H A GH
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGH 311
Query: 595 IDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRH 693
+V+LL+E + TK G S + +A Q H
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
Score = 90.1 bits (222), Expect = 7e-18
Identities = 45/150 (30%), Positives = 81/150 (54%)
Frame = +1
Query: 277 ACMRGYIDIVKILIDNKCDINASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDG 456
A G +D V + DIN ++ G +H A + GH+ +V+ L+ ++ +K G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 457 YQSMHLACMFGHIDIVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNA 636
++H+A + G ++VK+L+ +INA G+ P++ A ++ HID+VK L+EN N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQ-NGFTPLYMAAQENHIDVVKYLLENGANQ 156
Query: 637 KSLTKYGQSTIDIAKQNRHQTIIDILNSSD 726
+ T+ G + + +A Q H + IL +D
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLEND 186
Score = 88.6 bits (218), Expect = 2e-17
Identities = 44/150 (29%), Positives = 81/150 (54%)
Frame = +1
Query: 190 GNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGYQPI 369
GN+D + DINTC++ G +HLA G++ +V+ L+ ++++ K G +
Sbjct: 42 GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTAL 101
Query: 370 HFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDINASDN 549
H A G ++VK+L+ +IN S++G+ +++A HID+VK L+ + + +
Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATE 161
Query: 550 WMGYQPIHFACEKGHIDIVKLLIENKCNAK 639
G+ P+ A ++GH V +L+EN K
Sbjct: 162 -DGFTPLAVALQQGHNQAVAILLENDTKGK 190
Score = 82.4 bits (202), Expect = 1e-15
Identities = 44/165 (26%), Positives = 83/165 (50%)
Frame = +1
Query: 157 GNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDI 336
G LH + G+V + + L+ +++ + G +H+A + G ++VK+L+ +I
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 337 NASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILI 516
NA + G+ P++ A + HID+VK L++N + + ++DG+ + +A GH V IL+
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 517 ARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTK 651
N + + +H A K LL++N NA +K
Sbjct: 184 E-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 223
>sp|O89019|INVS_MOUSE Inversin (Inversion of embryo turning protein)
Length = 1062
Score = 111 bits (277), Expect = 3e-24
Identities = 64/244 (26%), Positives = 124/244 (50%), Gaps = 9/244 (3%)
Frame = +1
Query: 10 GHIDIVKILID-NKCDINALTKEGESPIDIAREKKHQQIIDI------LNSAAYPWGNQQ 168
GH IV +L++ NK +G +P+ A + + + + + + G
Sbjct: 266 GHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTS 325
Query: 169 LHYSCNNGNVDIAKTLIVNKCDI--NTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINA 342
++ GN D+ +T++ K DI N D++G +H A + G++ VK+L+DN ++A
Sbjct: 326 FMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDA 385
Query: 343 SDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIAR 522
+D + + P+ AC GH D+++ LI +++ +DG+ +H A + G+ D+ +ILI
Sbjct: 386 TDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
Query: 523 KCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTI 702
K + N D + G P+ A G+I+ + +L+EN + K G++ + + N +
Sbjct: 446 KINPNVQD-YAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDA 504
Query: 703 IDIL 714
I +L
Sbjct: 505 IKLL 508
Score = 90.9 bits (224), Expect = 4e-18
Identities = 52/207 (25%), Positives = 100/207 (48%), Gaps = 1/207 (0%)
Frame = +1
Query: 7 NGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQQLHYSCN 186
+GH+ VK+L+DN ++A +P L +C
Sbjct: 367 SGHVSTVKLLLDNDAQVDATDVMKHTP---------------------------LFRACE 399
Query: 187 NGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGYQP 366
G+ D+ +TLI ++ D+ G+ +H A + G D+ +ILI+NK + N D G P
Sbjct: 400 MGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTP 459
Query: 367 IHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDIN-AS 543
+ A G+I+ + +L++N D N+ K+G ++H +C G++D +K+L+ N
Sbjct: 460 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQME 519
Query: 544 DNWMGYQPIHFACEKGHIDIVKLLIEN 624
+N Y P+ +A ++++ ++E+
Sbjct: 520 NNEERYTPLDYALLGERHEVIQFMLEH 546
Score = 77.0 bits (188), Expect = 6e-14
Identities = 40/140 (28%), Positives = 68/140 (48%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQQLHYS 180
C+ GH D+++ LI ++ + ++G S LH++
Sbjct: 398 CEMGHRDVIQTLIKGGARVDLVDQDGHS---------------------------LLHWA 430
Query: 181 CNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGY 360
GN D+ + LI NK + N D G P+ A GYI+ + +L++N D N DK G
Sbjct: 431 ALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR 490
Query: 361 QPIHFACRNGHIDIVKILID 420
+H++C NG++D +K+L+D
Sbjct: 491 TALHWSCNNGYLDAIKLLLD 510
Score = 66.6 bits (161), Expect = 8e-11
Identities = 51/222 (22%), Positives = 99/222 (44%), Gaps = 15/222 (6%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWG------NQ 165
+ G+ +K+L+ + + E +P+ ++ + + + +L P N+
Sbjct: 90 QKGNYRFMKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNK 149
Query: 166 Q--LHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMR---GYIDIVKILID--- 321
Q LH+S N + AK LI + +I D G P+H A + V+ ++D
Sbjct: 150 QTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAP 209
Query: 322 NKCDINASDKIGYQPIHFACRNGHIDIVKILID-NKCDINVFSKDGYQSMHLACMFGHID 498
+ +N D G P+HFA +G++ +V +L C+I + +H A + GH
Sbjct: 210 TESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQ 269
Query: 499 IVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIEN 624
IV +L+ R + G P+H+A + + VK+ +++
Sbjct: 270 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQH 311
Score = 49.3 bits (116), Expect = 1e-05
Identities = 49/239 (20%), Positives = 88/239 (36%), Gaps = 44/239 (18%)
Frame = +1
Query: 154 WGNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCD 333
+G L Y VD A L+ D+N D +HLA +G +K+L+ + +
Sbjct: 47 FGRTPLMYCVLADRVDCADALLKAGADVNKTDHSRRTALHLAAQKGNYRFMKLLLTRRAN 106
Query: 334 INASDKIGYQPIHFACRNGHIDIVKILIDNKC--DINVFSKDGYQSMHLACMFGHIDIVK 507
D P+H + R+ + +L+ +++ K+ ++H + + + + K
Sbjct: 107 WMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAK 166
Query: 508 ILIARKCDINASD-----------------------------------NWMGYQ---PIH 573
+LI +I D NW Y+ P+H
Sbjct: 167 LLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLH 226
Query: 574 FACEKGHIDIVKLLIE-NKCNAKSLTKYGQSTIDIAKQNRHQTIIDIL---NSSDQIES 738
FA G++ +V +L CN S ++ + A H I+ +L N S I S
Sbjct: 227 FAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS 285
Score = 36.2 bits (82), Expect = 0.12
Identities = 21/97 (21%), Positives = 42/97 (43%), Gaps = 1/97 (1%)
Frame = +1
Query: 268 IHLACMRGYIDIV-KILIDNKCDINASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVF 444
+H A + G + ++++ N + D+ G P+ + +D L+ D+N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALRDKEDRFGRTPLMYCVLADRVDCADALLKAGADVNKT 77
Query: 445 SKDGYQSMHLACMFGHIDIVKILIARKCDINASDNWM 555
++HLA G+ +K+L+ R+ NWM
Sbjct: 78 DHSRRTALHLAAQKGNYRFMKLLLTRRA------NWM 108
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
serine/threonine-protein kinase 4) (Ankyrin repeat domain
protein 3) (PKC-delta-interacting protein kinase)
Length = 832
Score = 111 bits (277), Expect = 3e-24
Identities = 72/281 (25%), Positives = 126/281 (44%), Gaps = 39/281 (13%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQQ------L 171
G + K L+ N + N + G +P+ +A E++ + ++++L + + L
Sbjct: 497 GQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL 556
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
H++ NG+ + L+ +N D G P+H+AC G +IV+IL+ D++ K
Sbjct: 557 HFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGK 616
Query: 352 IGYQPIHFACRNGHIDIVKILIDNK-CDINVFSKDGYQSMHLACMFGHIDIVKILIARKC 528
+ P+H+A GH+ IVK+L +N + DG +HLA GH + +ILI
Sbjct: 617 DAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCS 676
Query: 529 DIN-----------------------------ASDNWM---GYQPIHFACEKGHIDIVKL 612
D+N A M GY +H A GH+ VKL
Sbjct: 677 DVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKL 736
Query: 613 LIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDILNSSDQIE 735
L+E K + + Q+ + +A + H +++ L S+D I+
Sbjct: 737 LVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVID 777
Score = 105 bits (262), Expect = 2e-22
Identities = 60/191 (31%), Positives = 102/191 (53%), Gaps = 5/191 (2%)
Frame = +1
Query: 157 GNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDI 336
G LH + G + AK L++N + N + G P+H+A R +V++L+ K +
Sbjct: 486 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 545
Query: 337 NASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILI 516
NA D+ + +HFA +NG ++L++ +N +G MH+AC G +IV+IL+
Sbjct: 546 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 605
Query: 517 ARKCDIN--ASDNWMGYQPIHFACEKGHIDIVKLLIEN---KCNAKSLTKYGQSTIDIAK 681
R D++ D W+ P+H+A +GH+ IVKLL + NA++L G++ + +A
Sbjct: 606 RRGVDVSLQGKDAWL---PLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD--GRTPLHLAA 660
Query: 682 QNRHQTIIDIL 714
Q H + IL
Sbjct: 661 QRGHYRVARIL 671
Score = 95.5 bits (236), Expect = 2e-19
Identities = 57/215 (26%), Positives = 101/215 (46%), Gaps = 7/215 (3%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILN-------SAAYPWG 159
C++G +IV+IL+ D++ K+ P+ A + H I+ +L +A G
Sbjct: 593 CQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDG 652
Query: 160 NQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDIN 339
LH + G+ +A+ LI D+N C P+H+A G+ ++L+
Sbjct: 653 RTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKE 712
Query: 340 ASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIA 519
A GY +H A RNGH+ VK+L++ K D+ ++HLA GH ++V+ L++
Sbjct: 713 AMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS 772
Query: 520 RKCDINASDNWMGYQPIHFACEKGHIDIVKLLIEN 624
D+ + G +H A + H V+ L+ +
Sbjct: 773 --ADVIDLFDEQGLSALHLAAQGRHAQTVETLLRH 805
>sp|O15084|ANR28_HUMAN Ankyrin repeat domain protein 28
Length = 1086
Score = 110 bits (276), Expect = 4e-24
Identities = 65/243 (26%), Positives = 118/243 (48%), Gaps = 7/243 (2%)
Frame = +1
Query: 7 NGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-------NSAAYPWGNQ 165
NG D V+ LI K D+N E +P+ A +II++L N+ W
Sbjct: 51 NGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTP 110
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
LH + + + + + L+ + D+N D+ P+H+A + + L+ ++N S
Sbjct: 111 -LHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVS 169
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
D+ G +H A +GH ++VK+L+ +IN F K +++H A GHI++VK+L++
Sbjct: 170 DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG 229
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTII 705
++ D Y P+H A G I +VK L++ + YG + + +A N ++
Sbjct: 230 AEVTCKDK-KSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVV 288
Query: 706 DIL 714
+ L
Sbjct: 289 NEL 291
Score = 105 bits (263), Expect = 1e-22
Identities = 68/240 (28%), Positives = 125/240 (52%), Gaps = 11/240 (4%)
Frame = +1
Query: 19 DIVKILIDNKCDINALTKEGESPIDIAREKKH----QQIIDILNSAAYP--WGNQQLHYS 180
+ V++L+ + D+NA K ++P+ IA K + ++ +L++ G LH++
Sbjct: 121 EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 180
Query: 181 CNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGY 360
+G+ ++ K L+ +IN D+ + IH A G+I++VK+L+ + ++ DK Y
Sbjct: 181 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSY 240
Query: 361 QPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDINA 540
P+H A +G I +VK L+D D+N + G +H+AC G +V LI +N
Sbjct: 241 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN- 299
Query: 541 SDNWMGYQPIHFACEKGHIDI-VKLLIENKCNAKSLTKYGQSTIDI----AKQNRHQTII 705
N G+ P+HFA H + ++LL+ N + +K G++ + + + +R QTII
Sbjct: 300 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 359
Score = 92.0 bits (227), Expect = 2e-18
Identities = 61/226 (26%), Positives = 108/226 (47%), Gaps = 14/226 (6%)
Frame = +1
Query: 7 NGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-NSAA------YPWGNQ 165
+GH +++L+ + D++ G +P+D+A K H + +D+L N A Y
Sbjct: 593 HGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRT 652
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEW---GYQPIHLACMRGYIDIVKILIDNKCDI 336
+H + NG+ + + LI N N D G P+ L+ + G+ D V L++ ++
Sbjct: 653 PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 712
Query: 337 NASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILI 516
+A DK G +H GH + V L+ + + G +HL+ GHI ++ L+
Sbjct: 713 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALL 772
Query: 517 ARKCDINA----SDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKS 642
++A +DN GY +H+AC GH V+LL+E + K+
Sbjct: 773 QSAASMDANPATADN-HGYTALHWACYNGHETCVELLLEQEVFQKT 817
Score = 90.9 bits (224), Expect = 4e-18
Identities = 71/278 (25%), Positives = 133/278 (47%), Gaps = 24/278 (8%)
Frame = +1
Query: 7 NGHIDIVKILIDNKCDINALTKE---GESPIDIAREKKHQQII-DILNSAAY-----PWG 159
NGH + +++LI N NA+ + G++P+ ++ H + +LN A WG
Sbjct: 660 NGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG 719
Query: 160 NQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDIN 339
LH G+ + L+ + D G PIHL+ G+I ++ L+ + ++
Sbjct: 720 RTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMD 779
Query: 340 AS----DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSK---DGYQSMHLACMFGHID 498
A+ D GY +H+AC NGH V++L++ + VF K + + +H A + +
Sbjct: 780 ANPATADNHGYTALHWACYNGHETCVELLLEQE----VFQKTEGNAFSPLHCAVINDNEG 835
Query: 499 IVKILIAR--KCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTID 672
++LI +NA+D+ G P+H A H++ ++LL+ + S+ G++ +
Sbjct: 836 AAEMLIDTLGASIVNATDS-KGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLM 894
Query: 673 IAKQNRHQTIIDILNSSDQIESIVK------ALNLQCS 768
+A +N +++L SS E ++ AL+L CS
Sbjct: 895 MAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACS 932
Score = 80.5 bits (197), Expect = 6e-15
Identities = 58/221 (26%), Positives = 101/221 (45%), Gaps = 5/221 (2%)
Frame = +1
Query: 73 EGESPIDIAREKKHQQIIDILNSAAYPWGNQQLHY-----SCNNGNVDIAKTLIVNKCDI 237
E ESP I++ + + + + P GN + Y + NG+ D + LI K D+
Sbjct: 13 EDESPAFISKLPQENKSLH-----SPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDV 67
Query: 238 NTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGYQPIHFACRNGHIDIVKILI 417
N D P+H A G +I+++LI + +NA D P+H A + + V++L+
Sbjct: 68 NFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLL 127
Query: 418 DNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDINASDNWMGYQPIHFACEKGHI 597
+ D+N K+ +H+A + + L+ ++N SD G +H A GH
Sbjct: 128 KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDR-AGRTALHHAAFSGHG 186
Query: 598 DIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDILNS 720
++VKLL+ N + K + I A H ++ +L S
Sbjct: 187 EMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 227
Score = 80.5 bits (197), Expect = 6e-15
Identities = 57/261 (21%), Positives = 115/261 (44%), Gaps = 7/261 (2%)
Frame = +1
Query: 25 VKILIDNKCDINALTKEGESPIDI-AREKKHQQIIDILNSAAY-----PWGNQQLHYSCN 186
+++L+ N D+N +K+G++P+ + A + + I+ S A GN LH +
Sbjct: 322 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 381
Query: 187 NGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGYQP 366
G+ + TLI + D G P+HLA + G+ D + L+ + DI+ D G
Sbjct: 382 YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 441
Query: 367 IHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDINASD 546
+H A G+++ + +L++ D N K G +H A + + L+ +N D
Sbjct: 442 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 501
Query: 547 NWMGYQPIHFACEKG-HIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDILNSS 723
G P+H+A ++ L+ N N K G + + + H+ + ++ S
Sbjct: 502 E-RGCTPLHYAATSDTDGKCLEYLLRNDANPGVRDKQGYNAVHYSAAYGHRLCLQLIASE 560
Query: 724 DQIESIVKALNLQCSINCDHK 786
++ +++ + D++
Sbjct: 561 TPLDVLMETSGTDMLSDSDNR 581
Score = 78.2 bits (191), Expect = 3e-14
Identities = 57/248 (22%), Positives = 103/248 (41%), Gaps = 1/248 (0%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQQLHYS 180
C NG +V LID +N ++G +P+ A H +
Sbjct: 280 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL------------------- 320
Query: 181 CNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGY 360
+ L+ N D+N + G P+H+ + G + +I + I+ DK G
Sbjct: 321 -------CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 373
Query: 361 QPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCDINA 540
P+H A R GH ++ LI + D G +HLA + G D + L++ DI+
Sbjct: 374 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 433
Query: 541 SDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQN-RHQTIIDILN 717
D++ G +H A G+++ + LL+ + K+G+S + A N +Q + ++
Sbjct: 434 PDDF-GRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVG 492
Query: 718 SSDQIESI 741
S + +
Sbjct: 493 SGASVNDL 500
Score = 77.8 bits (190), Expect = 4e-14
Identities = 64/287 (22%), Positives = 128/287 (44%), Gaps = 20/287 (6%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAREK-KHQQIIDILNSAAY-----PWGNQQL 171
G+++ + +L++ D N K G SP+ A +Q + ++ S A G L
Sbjct: 449 GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 508
Query: 172 HYSCNNG-NVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKIL-----IDNKCD 333
HY+ + + + L+ N + D+ GY +H + G+ ++++ +D +
Sbjct: 509 HYAATSDTDGKCLEYLLRNDANPGVRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLME 568
Query: 334 INASDKIG-------YQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGH 492
+ +D + P+H A +GH +++L+ + D++V + G + LA GH
Sbjct: 569 TSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGH 628
Query: 493 IDIVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTID 672
++ V +LI + I D + PIH A GH + ++LLI N Q+ +D
Sbjct: 629 VECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN--------AEPQNAVD 680
Query: 673 IAKQN-RHQTIIDILNSSDQIESIVKALNLQCSINCDHKFCRETLNK 810
I N + ++ +LN + + LN +++ K+ R L++
Sbjct: 681 IQDGNGQTPLMLSVLNG--HTDCVYSLLNKGANVDAKDKWGRTALHR 725
Score = 64.3 bits (155), Expect = 4e-10
Identities = 50/230 (21%), Positives = 101/230 (43%), Gaps = 14/230 (6%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINA----LTKEGESPIDIAREKKHQQIIDILNSAAY---PWGN-- 162
GHI ++ L+ + ++A G + + A H+ +++L GN
Sbjct: 763 GHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF 822
Query: 163 QQLHYSCNNGNVDIAKTLI--VNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDI 336
LH + N N A+ LI + +N D G P+H A +++ +++L+ + +
Sbjct: 823 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 882
Query: 337 NASDKIGYQPIHFACRNGHIDIVKILIDN-KCDINVFSKDGYQSMHLACMFGHIDIVKIL 513
N+ D G P+ A NG + V++L+ + ++ + ++HLAC GH ++
Sbjct: 883 NSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLI 942
Query: 514 IARKCDINA--SDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYG 657
+ + D N + N P+H A G +V+ L+ + ++ + G
Sbjct: 943 LEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENG 992
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/159 (22%), Positives = 73/159 (45%), Gaps = 3/159 (1%)
Frame = +1
Query: 13 HIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQQLHYSCNNG 192
H++ +++L+ + +N++ G++P+ +A E +++L S+A + +L N+
Sbjct: 868 HVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA----SAELTLQDNSK 923
Query: 193 NVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCD---INASDKIGYQ 363
N +HLAC +G+ ++++ D INA++
Sbjct: 924 NT----------------------ALHLACSKGHETSALLILEKITDRNLINATNAALQT 961
Query: 364 PIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLAC 480
P+H A RNG +V+ L+ + ++GY + LAC
Sbjct: 962 PLHVAARNGLTMVVQELLGKGASVLAVDENGY-TPALAC 999
>sp|Q9ULJ7|YB23_HUMAN Hypothetical protein KIAA1223
Length = 768
Score = 110 bits (276), Expect = 4e-24
Identities = 62/241 (25%), Positives = 118/241 (48%), Gaps = 6/241 (2%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILN------SAAYPWGNQQL 171
GH+D+V +L++ D++ G +P+ A H +++ L + G L
Sbjct: 98 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 157
Query: 172 HYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDK 351
+ GNV++ +TL+ D N D+ G+ P+H+A G+ I + LI+ N D
Sbjct: 158 SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDN 217
Query: 352 IGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARKCD 531
G P A + GH D V+IL++NK +I+ DG ++ +A + GH DIV++L + D
Sbjct: 218 DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 277
Query: 532 INASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDI 711
+N D G ++ + + + + +EN N ++ G++ + ++ H ++ +
Sbjct: 278 VNCKDA-DGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 336
Query: 712 L 714
L
Sbjct: 337 L 337
Score = 105 bits (263), Expect = 1e-22
Identities = 65/280 (23%), Positives = 131/280 (46%), Gaps = 45/280 (16%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDIL-----------NSAAYPW 156
G++++V+ L+D D N G +P+ +A + H+ I + L N P+
Sbjct: 164 GNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPF 223
Query: 157 --GNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKC 330
+Q+ HY C + L+ NK +I+ G + +A + G+ DIV++L +
Sbjct: 224 ILASQEGHYDC-------VQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 276
Query: 331 DINASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKI 510
D+N D G ++ + + + ++N ++ +G ++H++C GH+++V++
Sbjct: 277 DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 336
Query: 511 LIARKCDINASDN----------WMGY----------------------QPIHFACEKGH 594
LIA D+NA+DN W G+ + A ++GH
Sbjct: 337 LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 396
Query: 595 IDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTIIDIL 714
ID+V++L+E+ + ++G++ + +A +N H II +L
Sbjct: 397 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 436
Score = 105 bits (262), Expect = 2e-22
Identities = 63/239 (26%), Positives = 122/239 (51%), Gaps = 6/239 (2%)
Frame = +1
Query: 4 KNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPW------GNQ 165
+ GH D V+IL++NK +I+ +G + + +A + H+ I+++L S G
Sbjct: 228 QEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 287
Query: 166 QLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINAS 345
L+ + +A+ + N ++ D G +H++C +G++++V++LI D+NA+
Sbjct: 288 TLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAA 347
Query: 346 DKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILIARK 525
D + A GH+ +V++LI++ ++ G ++ +A GHID+V++L+
Sbjct: 348 DNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 407
Query: 526 CDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQTI 702
D N +D + G + A + GH I+KLL K A SL S + +Q Q++
Sbjct: 408 ADPNHADQF-GRTAMRVAAKNGHSQIIKLL--EKYGASSLNGCSPSPVHTMEQKPLQSL 463
Score = 94.4 bits (233), Expect = 4e-19
Identities = 64/248 (25%), Positives = 115/248 (46%), Gaps = 11/248 (4%)
Frame = +1
Query: 10 GHIDIVKILIDNKCDINALTKEGESPIDIAR-----EKKHQQIIDILNSAAYPW------ 156
GH +IV+ L+D+ ++N +G + + +A K H ++ +L
Sbjct: 27 GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKD 86
Query: 157 GNQQLHYSCNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDI 336
G L + G+VD+ L+ D++ D G P+ A G+ +V L+ +
Sbjct: 87 GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 146
Query: 337 NASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMFGHIDIVKILI 516
++ D G + A G++++V+ L+D D N G+ +H+A GH I + LI
Sbjct: 147 DSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALI 206
Query: 517 ARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYGQSTIDIAKQNRHQ 696
+ N DN G P A ++GH D V++L+ENK N G++ + +A H+
Sbjct: 207 EQGARTNEIDN-DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 265
Query: 697 TIIDILNS 720
I+++L S
Sbjct: 266 DIVELLFS 273
Score = 60.8 bits (146), Expect = 5e-09
Identities = 36/139 (25%), Positives = 70/139 (50%), Gaps = 5/139 (3%)
Frame = +1
Query: 313 LIDNKCDINASDKIGYQPIHFACRNGHIDIVKILIDNKCDINVFSKDGYQSMHLACMF-- 486
L+ + ++N +D G + A GH +IV+ L+D+ ++N DG ++ +A +
Sbjct: 2 LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 61
Query: 487 ---GHIDIVKILIARKCDINASDNWMGYQPIHFACEKGHIDIVKLLIENKCNAKSLTKYG 657
GH +V +LI R +++ D G P+ A +GH+D+V LL+E + G
Sbjct: 62 ASKGHASVVSLLIDRGAEVDHCDK-DGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 120
Query: 658 QSTIDIAKQNRHQTIIDIL 714
++ + A H ++++ L
Sbjct: 121 RTPLLAAASMGHASVVNTL 139
Score = 59.7 bits (143), Expect = 1e-08
Identities = 36/138 (26%), Positives = 68/138 (49%)
Frame = +1
Query: 1 CKNGHIDIVKILIDNKCDINALTKEGESPIDIAREKKHQQIIDILNSAAYPWGNQQLHYS 180
C GH+++V++LI D+NA E S + A + H +++ +L
Sbjct: 326 CWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL--------------- 370
Query: 181 CNNGNVDIAKTLIVNKCDINTCDEWGYQPIHLACMRGYIDIVKILIDNKCDINASDKIGY 360
I +V+ +TC++ G + +A G+ID+V++L+++ D N +D+ G
Sbjct: 371 -------IEHGAVVD----HTCNQ-GATALCIAAQEGHIDVVQVLLEHGADPNHADQFGR 418
Query: 361 QPIHFACRNGHIDIVKIL 414
+ A +NGH I+K+L
Sbjct: 419 TAMRVAAKNGHSQIIKLL 436
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,570,041
Number of Sequences: 369166
Number of extensions: 1984482
Number of successful extensions: 8600
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4942
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6665
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)