Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02950
(855 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43) 189 6e-48
sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43) 189 1e-47
sp|O43347|MSI1H_HUMAN RNA-binding protein Musashi homolog 1... 79 2e-14
sp|Q920Q6|MSI2H_MOUSE RNA-binding protein Musashi homolog 2... 78 4e-14
sp|Q8K3P4|MSI1H_RAT RNA-binding protein Musashi homolog 1 (... 78 4e-14
sp|Q96DH6|MSI2H_HUMAN RNA-binding protein Musashi homolog 2... 78 4e-14
sp|Q61474|MSI1H_MOUSE RNA-binding protein Musashi homolog 1... 78 4e-14
sp|P51991|ROA3_HUMAN Heterogeneous nuclear ribonucleoprotei... 77 5e-14
sp|Q8BG05|ROA3_MOUSE Heterogeneous nuclear ribonucleoprotei... 77 5e-14
sp|P21522|ROA1_SCHAM Heterogeneous nuclear ribonucleoprotei... 77 5e-14
>sp|Q13148|TADBP_HUMAN TAR DNA-binding protein 43 (TDP-43)
Length = 414
Score = 189 bits (481), Expect = 6e-48
Identities = 111/282 (39%), Positives = 158/282 (56%), Gaps = 18/282 (6%)
Frame = +1
Query: 1 DLKFICVFPKEIDNKRKCKEDYEISTPKTKRLETRKCTDLIVLNLGWKVDEEILRNYFSK 180
+L ++ +PK DNKRK E S K KR +K +DLIVL L WK E+ L+ YFS
Sbjct: 70 NLVYVVNYPK--DNKRKMDETDASSAVKVKRA-VQKTSDLIVLGLPWKTTEQDLKEYFST 126
Query: 181 FGELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAEKHLIDGRWCAVKVPFSKSEADK 360
FGE+++VQVKKD +T HSKG+ FVRF +Y+ QV ++++H+IDGRWC K+P SK D+
Sbjct: 127 FGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDE 186
Query: 361 QEISKKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFIPKPFRNFAFVTFDASDVAQQLIGR 540
S+K+ VG +E++ ++LR+ F +YG V D+FIPKPFR FAFVTF +AQ L G
Sbjct: 187 PLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGE 246
Query: 541 TVTLKGHALTIGSAVPKIS------------------GGKKGAQLAHGEQAAFSSNNRYN 666
+ +KG ++ I +A PK + G + G + G A +N N
Sbjct: 247 DLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSN 306
Query: 667 WGAAYEHAALKMAPYKSRQLRNSLAFGSYGGALMTTAGPNQS 792
G A + P + +L S+G M + NQS
Sbjct: 307 MGGGMNFGAFSINPAMMAAAQAALQ-SSWGMMGMLASQQNQS 347
>sp|Q921F2|TADBP_MOUSE TAR DNA-binding protein 43 (TDP-43)
Length = 414
Score = 189 bits (479), Expect = 1e-47
Identities = 112/282 (39%), Positives = 159/282 (56%), Gaps = 18/282 (6%)
Frame = +1
Query: 1 DLKFICVFPKEIDNKRKCKEDYEISTPKTKRLETRKCTDLIVLNLGWKVDEEILRNYFSK 180
+L ++ +PK DNKRK E S K KR +K +DLIVL L WK E+ L++YFS
Sbjct: 70 NLVYVVNYPK--DNKRKMDETDASSAVKVKRA-VQKTSDLIVLGLPWKTTEQDLKDYFST 126
Query: 181 FGELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAEKHLIDGRWCAVKVPFSKSEADK 360
FGE+++VQVKKD +T HSKG+ FVRF +Y+ QV ++++H+IDGRWC K+P SK D+
Sbjct: 127 FGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDE 186
Query: 361 QEISKKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFIPKPFRNFAFVTFDASDVAQQLIGR 540
S+K+ VG +E++ E+L++ F +YG V D+FIPKPFR FAFVTF VAQ L G
Sbjct: 187 PLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGE 246
Query: 541 TVTLKGHALTIGSAVPKIS------------------GGKKGAQLAHGEQAAFSSNNRYN 666
+ +KG ++ I +A PK + G + G + G A +N N
Sbjct: 247 DLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGN 306
Query: 667 WGAAYEHAALKMAPYKSRQLRNSLAFGSYGGALMTTAGPNQS 792
G A + P + +L S+G M + NQS
Sbjct: 307 MGGGMNFGAFSINPAMMAAAQAALQ-SSWGMMGMLASQQNQS 347
>sp|O43347|MSI1H_HUMAN RNA-binding protein Musashi homolog 1 (Musashi-1)
Length = 362
Score = 78.6 bits (192), Expect = 2e-14
Identities = 48/145 (33%), Positives = 76/145 (52%), Gaps = 7/145 (4%)
Frame = +1
Query: 118 LIVLNLGWKVDEEILRNYFSKFGELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAE- 294
+ + L W+ +E LR YF +FGE+ V +D T S+G+ FV F D G LA+
Sbjct: 22 MFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQS 81
Query: 295 KHLIDGRWCAVKVPFSKSEADKQEI-SKKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFI- 468
+H +D + KV F + K +KKI VG S +ED+++ FE++G V D +
Sbjct: 82 RHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLM 141
Query: 469 ----PKPFRNFAFVTFDASDVAQQL 531
R F FVTF++ D+ +++
Sbjct: 142 FDKTTNRHRGFGFVTFESEDIVEKV 166
>sp|Q920Q6|MSI2H_MOUSE RNA-binding protein Musashi homolog 2 (Musashi-2)
Length = 346
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/145 (33%), Positives = 74/145 (51%), Gaps = 7/145 (4%)
Frame = +1
Query: 118 LIVLNLGWKVDEEILRNYFSKFGELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAE- 294
+ + L W+ + LR+YFSKFGE+ V +D T S+G+ FV FAD L +
Sbjct: 23 MFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQP 82
Query: 295 KHLIDGRWCAVKVPFSKSEADKQEI-SKKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFI- 468
H +D + KV F + K +KKI VG S +ED+++ FE++G V D +
Sbjct: 83 HHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLM 142
Query: 469 ----PKPFRNFAFVTFDASDVAQQL 531
R F FVTF+ DV +++
Sbjct: 143 FDKTTNRHRGFGFVTFENEDVVEKV 167
>sp|Q8K3P4|MSI1H_RAT RNA-binding protein Musashi homolog 1 (Musashi-1)
Length = 362
Score = 77.8 bits (190), Expect = 4e-14
Identities = 48/145 (33%), Positives = 75/145 (51%), Gaps = 7/145 (4%)
Frame = +1
Query: 118 LIVLNLGWKVDEEILRNYFSKFGELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAE- 294
+ + L W+ +E LR YF +FGE+ V +D T S+G+ FV F D G LA+
Sbjct: 22 MFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQS 81
Query: 295 KHLIDGRWCAVKVPFSKSEADKQEI-SKKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFI- 468
+H +D + KV F + K +KKI VG S +ED++ FE++G V D +
Sbjct: 82 RHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKHYFEQFGKVDDAMLM 141
Query: 469 ----PKPFRNFAFVTFDASDVAQQL 531
R F FVTF++ D+ +++
Sbjct: 142 FDKTTNRHRGFGFVTFESEDIVEKV 166
>sp|Q96DH6|MSI2H_HUMAN RNA-binding protein Musashi homolog 2 (Musashi-2)
Length = 328
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/145 (33%), Positives = 74/145 (51%), Gaps = 7/145 (4%)
Frame = +1
Query: 118 LIVLNLGWKVDEEILRNYFSKFGELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAE- 294
+ + L W+ + LR+YFSKFGE+ V +D T S+G+ FV FAD L +
Sbjct: 23 MFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQP 82
Query: 295 KHLIDGRWCAVKVPFSKSEADKQEI-SKKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFI- 468
H +D + KV F + K +KKI VG S +ED+++ FE++G V D +
Sbjct: 83 HHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLM 142
Query: 469 ----PKPFRNFAFVTFDASDVAQQL 531
R F FVTF+ DV +++
Sbjct: 143 FDKTTNRHRGFGFVTFENEDVVEKV 167
>sp|Q61474|MSI1H_MOUSE RNA-binding protein Musashi homolog 1 (Musashi-1)
Length = 362
Score = 77.8 bits (190), Expect = 4e-14
Identities = 48/145 (33%), Positives = 75/145 (51%), Gaps = 7/145 (4%)
Frame = +1
Query: 118 LIVLNLGWKVDEEILRNYFSKFGELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAE- 294
+ + L W+ +E LR YF +FGE+ V +D T S+G+ FV F D G LA+
Sbjct: 22 MFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQS 81
Query: 295 KHLIDGRWCAVKVPFSKSEADKQEI-SKKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFI- 468
+H +D + KV F + K +KKI VG S +ED++ FE++G V D +
Sbjct: 82 RHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKHYFEQFGKVDDAMLM 141
Query: 469 ----PKPFRNFAFVTFDASDVAQQL 531
R F FVTF++ D+ +++
Sbjct: 142 FDKTTNRHRGFGFVTFESEDIVEKV 166
>sp|P51991|ROA3_HUMAN Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
Length = 378
Score = 77.4 bits (189), Expect = 5e-14
Identities = 61/213 (28%), Positives = 99/213 (46%), Gaps = 11/213 (5%)
Frame = +1
Query: 25 PKEIDNKRKCKEDYEISTPKTKRLETRKCTDLIVLNLGWKVDEEILRNYFSKFGELVLVQ 204
P+ +R+ + E PK E + L + L ++ ++ LR +F K+G L
Sbjct: 10 PQPDSGRRRRRRGEEGHDPK----EPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCV 65
Query: 205 VKKDRETNHSKGYAFVRFADYD--GQVLCLAEKHLIDGRWCAVKVPFSKSEADKQEIS-- 372
V +D +T S+G+ FV ++ + +C A H +DGR K S+ ++ K
Sbjct: 66 VMRDPQTKRSRGFGFVTYSCVEEVDAAMC-ARPHKVDGRVVEPKRAVSREDSVKPGAHLT 124
Query: 373 -KKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFIPK-----PFRNFAFVTFDASDVAQQLI 534
KKI VG E+ E +LR FE+YG + I + + R FAFVTFD D +++
Sbjct: 125 VKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIV 184
Query: 535 GRTV-TLKGHALTIGSAVPKISGGKKGAQLAHG 630
+ T+ GH + A+ K G+Q G
Sbjct: 185 VQKYHTINGHNCEVKKALSKQEMQSAGSQRGRG 217
Score = 55.5 bits (132), Expect = 2e-07
Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 4/117 (3%)
Frame = +1
Query: 13 ICVFPKEIDNK---RKCKEDYEISTPKTKRLETRKCTDLIVLNLGWKVDEEILRNYFSKF 183
+C P ++D + K E S L +K + V + +E LR+YF K+
Sbjct: 93 MCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKK---IFVGGIKEDTEEYNLRDYFEKY 149
Query: 184 GELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAEK-HLIDGRWCAVKVPFSKSE 351
G++ ++V +DR++ +G+AFV F D+D + +K H I+G C VK SK E
Sbjct: 150 GKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQE 206
>sp|Q8BG05|ROA3_MOUSE Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
sp|Q6URK4|ROA3_RAT Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
Length = 379
Score = 77.4 bits (189), Expect = 5e-14
Identities = 61/213 (28%), Positives = 99/213 (46%), Gaps = 11/213 (5%)
Frame = +1
Query: 25 PKEIDNKRKCKEDYEISTPKTKRLETRKCTDLIVLNLGWKVDEEILRNYFSKFGELVLVQ 204
P+ +R+ + E PK E + L + L ++ ++ LR +F K+G L
Sbjct: 10 PQPDSGRRRRRRGEEGHDPK----EPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCV 65
Query: 205 VKKDRETNHSKGYAFVRFADYD--GQVLCLAEKHLIDGRWCAVKVPFSKSEADKQEIS-- 372
V +D +T S+G+ FV ++ + +C A H +DGR K S+ ++ K
Sbjct: 66 VMRDPQTKRSRGFGFVTYSCVEEVDAAMC-ARPHKVDGRVVEPKRAVSREDSVKPGAHLT 124
Query: 373 -KKIHVGYNSEEIEMEDLRKSFEEYGYVTDIFIPK-----PFRNFAFVTFDASDVAQQLI 534
KKI VG E+ E +LR FE+YG + I + + R FAFVTFD D +++
Sbjct: 125 VKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIV 184
Query: 535 GRTV-TLKGHALTIGSAVPKISGGKKGAQLAHG 630
+ T+ GH + A+ K G+Q G
Sbjct: 185 VQKYHTINGHNCEVKKALSKQEMQSAGSQRGRG 217
Score = 55.5 bits (132), Expect = 2e-07
Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 4/117 (3%)
Frame = +1
Query: 13 ICVFPKEIDNK---RKCKEDYEISTPKTKRLETRKCTDLIVLNLGWKVDEEILRNYFSKF 183
+C P ++D + K E S L +K + V + +E LR+YF K+
Sbjct: 93 MCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKK---IFVGGIKEDTEEYNLRDYFEKY 149
Query: 184 GELVLVQVKKDRETNHSKGYAFVRFADYDGQVLCLAEK-HLIDGRWCAVKVPFSKSE 351
G++ ++V +DR++ +G+AFV F D+D + +K H I+G C VK SK E
Sbjct: 150 GKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQE 206
>sp|P21522|ROA1_SCHAM Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog
Length = 342
Score = 77.4 bits (189), Expect = 5e-14
Identities = 57/180 (31%), Positives = 90/180 (50%), Gaps = 15/180 (8%)
Frame = +1
Query: 118 LIVLNLGWKVDEEILRNYFSKFGELVLVQVKKDRETNHSKGYAFVRFADY----DGQVLC 285
L + L ++ +E L+ +F ++GE+V V V KD +T S+G+ F+ ++ D Q
Sbjct: 19 LFIGGLDYRTTDESLKQHFEQWGEIVDVVVMKDPKTKRSRGFGFITYSRAHMVDDAQ--- 75
Query: 286 LAEKHLIDGRWCAVKVPFSKSEADKQEIS---KKIHVGYNSEEIEMEDLRKSFEEYGYVT 456
A H +DGR K ++E + E KK+ VG EE+E DLR F++YG V
Sbjct: 76 NARPHKVDGRVVEPKRAVPRTEIGRPEAGATVKKLFVGGIKEEMEENDLRDYFKQYGTVV 135
Query: 457 DIFI-----PKPFRNFAFVTFDASDVAQQL-IGRTVTLKGHALTIGSAVPK--ISGGKKG 612
I + R FAFV FD D ++ + R ++G + + A+PK GG+ G
Sbjct: 136 SAAIVVDKETRKKRGFAFVEFDDYDPVDKICLSRNHQIRGKHIDVKKALPKGDAPGGRGG 195
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,663,193
Number of Sequences: 369166
Number of extensions: 1963555
Number of successful extensions: 8908
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7938
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8770
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)