Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02872
(532 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P98083|SHC1_MOUSE SHC transforming protein 1 (SH2 domain... 50 3e-06
sp|P29353|SHC1_HUMAN SHC transforming protein 1 (SH2 domain... 49 8e-06
sp|P07332|FES_HUMAN Proto-oncogene tyrosine-protein kinase ... 45 1e-04
sp|P18106|FPS_DROME Tyrosine-protein kinase Fps85D (dFer) 43 4e-04
sp|P16879|FES_MOUSE Proto-oncogene tyrosine-protein kinase ... 43 5e-04
sp|Q92529|SHC3_HUMAN SHC transforming protein 3 (SH2 domain... 42 7e-04
sp|P16591|FER_HUMAN Proto-oncogene tyrosine-protein kinase ... 42 0.001
sp|Q61120|SHC3_MOUSE SHC transforming protein 3 (SH2 domain... 42 0.001
sp|O70143|SHC3_RAT SHC transforming protein 3 (SH2 domain p... 42 0.001
sp|P14238|FES_FELCA Proto-oncogene tyrosine-protein kinase ... 41 0.002
>sp|P98083|SHC1_MOUSE SHC transforming protein 1 (SH2 domain protein C1) (Src homology 2
domain containing transforming protein C1)
Length = 579
Score = 50.1 bits (118), Expect = 3e-06
Identities = 32/105 (30%), Positives = 48/105 (45%), Gaps = 1/105 (0%)
Frame = +2
Query: 137 LKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSKWNGXXXXXXXXXXXXXX 316
L+ WFHG + R EAE+ + NG+FLVR S ++V++ +G
Sbjct: 479 LQGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 538
Query: 317 XXCLVYFINSKFKFPTVLELIKFHKDNQYP-LSDASEAVLYKPID 448
+F +V LI +H DN P +S SE L +P+D
Sbjct: 539 R-------TKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVD 576
>sp|P29353|SHC1_HUMAN SHC transforming protein 1 (SH2 domain protein C1) (Src homology 2
domain containing transforming protein C1)
Length = 583
Score = 48.9 bits (115), Expect = 8e-06
Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 1/105 (0%)
Frame = +2
Query: 137 LKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSKWNGXXXXXXXXXXXXXX 316
L+ WFHG + R EAE+ + NG+FLVR S ++V++ +G
Sbjct: 483 LRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVV 542
Query: 317 XXCLVYFINSKFKFPTVLELIKFHKDNQYP-LSDASEAVLYKPID 448
+F +V LI +H DN P +S SE L +P++
Sbjct: 543 R-------TKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVE 580
>sp|P07332|FES_HUMAN Proto-oncogene tyrosine-protein kinase Fes/Fps (C-Fes)
Length = 822
Score = 45.1 bits (105), Expect = 1e-04
Identities = 33/120 (27%), Positives = 56/120 (46%)
Frame = +2
Query: 86 IDPKLLFDNEINKQMDLLKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSK 265
+ P L E+ K L + +W+HG I R E + ++G+FLVR S+ K ++V+S
Sbjct: 441 LPPPLQLIPEVQKP---LHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGK-QEYVLSVL 496
Query: 266 WNGXXXXXXXXXXXXXXXXCLVYFINSKFKFPTVLELIKFHKDNQYPLSDASEAVLYKPI 445
W+G +Y + + FP++ LI Q PL+ S VL++ +
Sbjct: 497 WDGLPRHFIIQSLDN------LYRLEGE-GFPSIPLLIDHLLSTQQPLTKKSGVVLHRAV 549
>sp|P18106|FPS_DROME Tyrosine-protein kinase Fps85D (dFer)
Length = 1325
Score = 43.1 bits (100), Expect = 4e-04
Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Frame = +2
Query: 137 LKDSIWFHGVIGRTEAESRIFNNGEFLVRFS-EDKTNKFVVSSKWNGXXXXXXXXXXXXX 313
L + WFHGV+ R E + N+G+FLVR + ++ ++ V+S WNG
Sbjct: 955 LYEEEWFHGVLpreEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEG- 1013
Query: 314 XXXCLVYFINSKFK---FPTVLELIKFHKDNQYPLSDASEAVLYKPI 445
N +F+ F ++ ELI ++ P++ S A+L +P+
Sbjct: 1014 ---------NFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPV 1051
>sp|P16879|FES_MOUSE Proto-oncogene tyrosine-protein kinase Fes/Fps (C-Fes)
Length = 820
Score = 42.7 bits (99), Expect = 5e-04
Identities = 32/125 (25%), Positives = 58/125 (46%), Gaps = 5/125 (4%)
Frame = +2
Query: 86 IDPKLLFDNEINKQMDLLKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSK 265
I P L E+ K L + +W+HG I E + + G+FLVR S+ K ++V+S
Sbjct: 439 IPPPLQLVPEVQKP---LYEQLWYHGAIPWAEVAELLTHTGDFLVRESQGK-QEYVLSVM 494
Query: 266 WNGXXXXXXXXXXXXXXXXCLVYFINSKFK-----FPTVLELIKFHKDNQYPLSDASEAV 430
W+G ++ +++ ++ FP++ LI +Q PL+ S V
Sbjct: 495 WDGHPRHF------------IIQSLDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVV 542
Query: 431 LYKPI 445
L++ +
Sbjct: 543 LFRAV 547
>sp|Q92529|SHC3_HUMAN SHC transforming protein 3 (SH2 domain protein C3) (Src homology 2
domain containing transforming protein C3) (Neuronal
Shc) (N-Shc) (Protein Rai)
Length = 594
Score = 42.4 bits (98), Expect = 7e-04
Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 2/111 (1%)
Frame = +2
Query: 122 KQMDLLKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSKWNGXXXXXXXXX 301
K ++ L+ W+ G + R EAE + +G+FLVR S FV++ NG
Sbjct: 489 KMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVD 548
Query: 302 XXXXXXXCLVYFINSKFK-FPTVLELIKFHKDNQYPL-SDASEAVLYKPID 448
I +K + F ++ LI H ++ P+ S SE L +P++
Sbjct: 549 PEGT--------IRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVE 591
>sp|P16591|FER_HUMAN Proto-oncogene tyrosine-protein kinase FER (p94-FER) (c-FER)
Length = 822
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/108 (25%), Positives = 49/108 (45%), Gaps = 5/108 (4%)
Frame = +2
Query: 137 LKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSKWNGXXXXXXXXXXXXXX 316
L + W+HG I R EA+ + G+FLVR S K ++V+S +G
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHF--------- 505
Query: 317 XXCLVYFINSKFK-----FPTVLELIKFHKDNQYPLSDASEAVLYKPI 445
++ ++++ ++ F + +LI H + ++ S VL PI
Sbjct: 506 ---IIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPI 550
>sp|Q61120|SHC3_MOUSE SHC transforming protein 3 (SH2 domain protein C3) (Src homology 2
domain containing transforming protein C3) (Neuronal
Shc) (N-Shc)
Length = 474
Score = 42.0 bits (97), Expect = 0.001
Identities = 29/111 (26%), Positives = 51/111 (45%), Gaps = 2/111 (1%)
Frame = +2
Query: 122 KQMDLLKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSKWNGXXXXXXXXX 301
+ ++ L W+ G + R EAE+ + +G+FLVR S FV++ NG
Sbjct: 369 RMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVD 428
Query: 302 XXXXXXXCLVYFINSKFK-FPTVLELIKFHKDNQYPL-SDASEAVLYKPID 448
I +K + F ++ LI +H ++ P+ S SE L +P++
Sbjct: 429 PEGT--------IRTKDRVFDSISHLINYHLESSLPIVSAGSELCLQQPVE 471
>sp|O70143|SHC3_RAT SHC transforming protein 3 (SH2 domain protein C3) (Src homology 2
domain containing transforming protein C3) (Neuronal
Shc) (N-Shc)
Length = 594
Score = 42.0 bits (97), Expect = 0.001
Identities = 29/111 (26%), Positives = 51/111 (45%), Gaps = 2/111 (1%)
Frame = +2
Query: 122 KQMDLLKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSKWNGXXXXXXXXX 301
K ++ L W+ G + R EAE+ + +G+FLVR S FV++ NG
Sbjct: 489 KMLEELNAEPWYQGEMSRKEAEALLQEDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVD 548
Query: 302 XXXXXXXCLVYFINSKFK-FPTVLELIKFHKDNQYPL-SDASEAVLYKPID 448
+ +K + F ++ LI +H ++ P+ S SE L +P++
Sbjct: 549 PEGT--------VRTKDRVFDSISHLITYHLESSLPIVSAGSELCLRQPVE 591
>sp|P14238|FES_FELCA Proto-oncogene tyrosine-protein kinase FES/FPS (C-FES)
Length = 820
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/63 (33%), Positives = 36/63 (57%)
Frame = +2
Query: 86 IDPKLLFDNEINKQMDLLKDSIWFHGVIGRTEAESRIFNNGEFLVRFSEDKTNKFVVSSK 265
+ P L E+ K L + +W+HG + R E + ++G+FLVR S+ K ++V+S
Sbjct: 439 LPPPLQLVPEVQKP---LHEQLWYHGALPRAEVAELLTHSGDFLVRESQGK-QEYVLSVL 494
Query: 266 WNG 274
W+G
Sbjct: 495 WDG 497
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,487,247
Number of Sequences: 369166
Number of extensions: 1182474
Number of successful extensions: 3258
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3188
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3239
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3600891075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)