Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02778
(857 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UQ13|SHOC2_HUMAN Leucine-rich repeat protein SHOC-2 (R... 303 3e-82
sp|O88520|SHOC2_MOUSE Leucine-rich repeat protein SHOC-2 (R... 300 4e-81
sp|Q80VQ1|LRRC1_MOUSE Leucine-rich repeat-containing protein 1 134 4e-31
sp|Q9BTT6|LRRC1_HUMAN Leucine-rich repeat-containing protei... 132 1e-30
sp|O61967|LAP1_CAEEL Lap1 protein (Lethal protein 413) 131 2e-30
sp|Q7KRY7|LAP4_DROME LAP4 protein (Scribble protein) (Smell... 128 2e-29
sp|Q96NW7|LRRC7_HUMAN Leucine-rich repeat-containing protei... 125 2e-28
sp|P70587|LRRC7_RAT Leucine-rich repeat-containing protein ... 124 3e-28
sp|Q80TE7|LRRC7_MOUSE Leucine-rich repeat-containing protei... 124 3e-28
sp|Q96RT1|LAP2_HUMAN LAP2 protein (Erbb2-interacting protei... 123 6e-28
>sp|Q9UQ13|SHOC2_HUMAN Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8)
Length = 582
Score = 303 bits (777), Expect = 3e-82
Identities = 157/274 (57%), Positives = 207/274 (75%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
SK I LPS+IK+L L ELYLYSNKL +LP E+G LVNL L L EN +T+LPDSL
Sbjct: 108 SKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLD 166
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
+ LR+LD+RHNKL EIP V++L +LT L LRFNRI V+++I NL KL L++RENK
Sbjct: 167 NLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENK 226
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
I+ LP+ G +L NL TLD++HN LE LP+ IG+CT++T L+LQHNEL +P+TIGNL+
Sbjct: 227 IKQLPAEIG--ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
+L R GLRYN L+++P SL+ C L ELN E NNIS LPE LL+ L+ ++S+TL+RN F
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344
Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIPFGILSRA 822
+P+GGP QF++ +LN++HN+I +IPFGI SRA
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378
Score = 96.7 bits (239), Expect = 7e-20
Identities = 76/269 (28%), Positives = 130/269 (48%), Gaps = 47/269 (17%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+ LP I + + L L N+L++LP+ +GNL +L L L+ N ++A+P SL++C
Sbjct: 248 NQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKC 306
Query: 187 RLLRILDIRHNKLCEIPPFVF----KLHNLT---------------------HLLLRFNR 291
L L++ +N + +P + KL++LT L + NR
Sbjct: 307 SALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNR 366
Query: 292 IREVDQEIANLEK-LQNLTLRENKIRLLPSNPG---------------------LEKLVN 405
I ++ I + K L L +++N++ LP + G + LV+
Sbjct: 367 INKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVS 426
Query: 406 LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
L+ L +S+N L+ LP +G+ KL L+L+ N+L+S+P I L L++ L N LT+L
Sbjct: 427 LEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTL 486
Query: 586 PASLSFCRMLCELNTEGNNISQLPEGLLT 672
P + L L N ++ LPE + T
Sbjct: 487 PRGIGHLTNLTHLGLGENLLTHLPEEIGT 515
Score = 90.1 bits (222), Expect = 7e-18
Identities = 59/175 (33%), Positives = 98/175 (56%), Gaps = 1/175 (0%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+TSLP + ++ EL L +N+L +P ++ LV+LE+L+L N + LP L
Sbjct: 389 NQLTSLPLDFGTWT-SMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNL 447
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
R LR LD+ NKL +P + L +L L+L N++ + + I +L L +L L EN +
Sbjct: 448 RKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT 507
Query: 367 LLPSNPGLEKLVNLQTLDISHN-HLEMLPEAIGHCTKLTTLNLQHNELKSIPETI 528
LP G L NL+ L ++ N +L LP + C+KL+ +++++ L +P I
Sbjct: 508 HLPEEIG--TLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 66.2 bits (160), Expect = 1e-10
Identities = 46/159 (28%), Positives = 77/159 (48%)
Frame = +1
Query: 325 EKLQNLTLRENKIRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNE 504
E L L + I +LPS+ +++L L L + N L+ LP +G L TL L N
Sbjct: 100 ENSMRLDLSKRSIHILPSS--IKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
Query: 505 LKSIPETIGNLTALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIH 684
L S+P+++ NL L LR+N L +P+ + L L N I+ + E + +L
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV-EKDIKNLSK 216
Query: 685 VSSITLSRNYFSSFPLGGPQQFASTQTLNLDHNQITQIP 801
+S +++ N P + + TL++ HNQ+ +P
Sbjct: 217 LSMLSIRENKIKQLP-AEIGELCNLITLDVAHNQLEHLP 254
>sp|O88520|SHOC2_MOUSE Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8)
Length = 582
Score = 300 bits (767), Expect = 4e-81
Identities = 154/274 (56%), Positives = 206/274 (75%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
SK I LP ++K+L L ELYLYSNKL +LP E+G LVNL L L EN +T+LPDSL
Sbjct: 108 SKRSIHILPPSVKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLD 166
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
+ LR+LD+RHNKL EIP V++L +LT L LRFNRI V+++I NL KL L++RENK
Sbjct: 167 NLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKLSMLSIRENK 226
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
I+ LP+ G +L NL TLD++HN LE LP+ IG+CT++T L+LQHN+L +P+TIGNL+
Sbjct: 227 IKQLPAEIG--ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDLLDLPDTIGNLS 284
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
+L R GLRYN L+++P SL+ C L ELN E NNIS LPE LL+ L+ ++S+TL+RN F
Sbjct: 285 SLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344
Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIPFGILSRA 822
+P+GGP QF++ +LN++HN+I +IPFGI SRA
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378
Score = 94.4 bits (233), Expect = 4e-19
Identities = 75/269 (27%), Positives = 129/269 (47%), Gaps = 47/269 (17%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+ LP I + + L L N L++LP+ +GNL +L L L+ N ++A+P SL++C
Sbjct: 248 NQLEHLPKEIGNCTQ-ITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKC 306
Query: 187 RLLRILDIRHNKLCEIPPFVF----KLHNLT---------------------HLLLRFNR 291
L L++ +N + +P + KL++LT L + NR
Sbjct: 307 SALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNR 366
Query: 292 IREVDQEIANLEK-LQNLTLRENKIRLLPSNPG---------------------LEKLVN 405
I ++ I + K L L +++N++ LP + G + LV+
Sbjct: 367 INKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVS 426
Query: 406 LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
L+ L +S+N L+ LP +G+ KL L+L+ N+L+S+P I L L++ L N L++L
Sbjct: 427 LEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTL 486
Query: 586 PASLSFCRMLCELNTEGNNISQLPEGLLT 672
P + L L N ++ LPE + T
Sbjct: 487 PRGIGHLTNLTHLGLGENLLTHLPEEIGT 515
Score = 90.1 bits (222), Expect = 7e-18
Identities = 59/175 (33%), Positives = 98/175 (56%), Gaps = 1/175 (0%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+TSLP + ++ EL L +N+L +P ++ LV+LE+L+L N + LP L
Sbjct: 389 NQLTSLPLDFGTWT-SMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNL 447
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
R LR LD+ NKL +P + L +L L+L N++ + + I +L L +L L EN +
Sbjct: 448 RKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLT 507
Query: 367 LLPSNPGLEKLVNLQTLDISHN-HLEMLPEAIGHCTKLTTLNLQHNELKSIPETI 528
LP G L NL+ L ++ N +L LP + C+KL+ +++++ L +P I
Sbjct: 508 HLPEEIG--TLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 66.2 bits (160), Expect = 1e-10
Identities = 46/159 (28%), Positives = 76/159 (47%)
Frame = +1
Query: 325 EKLQNLTLRENKIRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNE 504
E L L + I +LP P +++L L L + N L+ LP +G L TL L N
Sbjct: 100 ENSMRLDLSKRSIHILP--PSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
Query: 505 LKSIPETIGNLTALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIH 684
L S+P+++ NL L LR+N L +P+ + L L N I+ + E + +L
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV-EKDIKNLPK 216
Query: 685 VSSITLSRNYFSSFPLGGPQQFASTQTLNLDHNQITQIP 801
+S +++ N P + + TL++ HNQ+ +P
Sbjct: 217 LSMLSIRENKIKQLP-AEIGELCNLITLDVAHNQLEHLP 254
>sp|Q80VQ1|LRRC1_MOUSE Leucine-rich repeat-containing protein 1
Length = 524
Score = 134 bits (336), Expect = 4e-31
Identities = 85/220 (38%), Positives = 121/220 (55%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + +T LP + +L NL L + L +LP +GNL NL L L+EN +T LPDSL+
Sbjct: 113 SGNPLTRLPESFPEL-QNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLT 171
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
Q R L LD+ +N++ +P + L +L L L N++ E+ QEI NL+ L L + EN+
Sbjct: 172 QLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENR 231
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
+ LP + L +L L IS N LE +PE IG KL+ L L N L +PE IG+
Sbjct: 232 LERLPEE--ISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIGDCE 289
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE 660
L L N L +LP S+ + L LN + N + LP+
Sbjct: 290 NLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPK 329
Score = 114 bits (285), Expect = 3e-25
Identities = 77/241 (31%), Positives = 122/241 (50%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+ LP L L++L L N++ LP E+ N + L L + N + +P+S++ C
Sbjct: 46 NQLRELPEQFFQLV-KLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESIAFC 104
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L++ D N L +P +L NLT L + ++ + + I NL L +L LREN +
Sbjct: 105 KALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLT 164
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP + L +L L+ LD+ +N + LPE+IG L L L N+L +P+ IGNL L
Sbjct: 165 YLPDS--LTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSF 726
+ N L LP +S L L N + +PEG + L +S + L +N +
Sbjct: 223 LCLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEG-IGKLKKLSILKLDQNRLTQL 281
Query: 727 P 729
P
Sbjct: 282 P 282
Score = 112 bits (279), Expect = 2e-24
Identities = 78/263 (29%), Positives = 132/263 (50%)
Frame = +1
Query: 22 LPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRI 201
+P I A +L+EL L +N+L LP + LV L L L +N + LP ++ L
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
Query: 202 LDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSN 381
LD+ N + EIP + L N + + + L+ L L++ + ++ LP N
Sbjct: 87 LDVSRNDIPEIPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
Query: 382 PGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGL 561
G L NL +L++ N L LP+++ +L L+L +NE+ ++PE+IG L L+ L
Sbjct: 147 IG--NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWL 204
Query: 562 RYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGP 741
N L+ LP + + L L+ N + +LPE ++ L ++ + +S+N + P G
Sbjct: 205 DGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGLTSLTYLVISQNLLETIP-EGI 262
Query: 742 QQFASTQTLNLDHNQITQIPFGI 810
+ L LD N++TQ+P I
Sbjct: 263 GKLKKLSILKLDQNRLTQLPEAI 285
Score = 87.0 bits (214), Expect = 6e-17
Identities = 54/177 (30%), Positives = 90/177 (50%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q++ LP I +L NL L + N+L LP E+ L +L L++ +N + +P+ + +
Sbjct: 207 NQLSELPQEIGNLK-NLLCLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEGIGKL 265
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L IL + N+L ++P + NLT L+L NR+ + + I L+KL NL NK+
Sbjct: 266 KKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLV 325
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNL 537
LP G +L I N L LP + +L L++ N L +P ++ L
Sbjct: 326 SLPKEIG--GCCSLTMFCIRDNRLTRLPAEVSQAVELHVLDVAGNRLHHLPLSLTTL 380
>sp|Q9BTT6|LRRC1_HUMAN Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein)
(LANO adapter protein)
Length = 524
Score = 132 bits (332), Expect = 1e-30
Identities = 82/220 (37%), Positives = 121/220 (55%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + +T LP + +L NL L + L +LP +GNL NL L L+EN +T LPDSL+
Sbjct: 113 SGNPLTRLPESFPEL-QNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLT 171
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
Q R L LD+ +N++ +P + L +L L L N++ E+ QEI NL+ L L + EN+
Sbjct: 172 QLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENR 231
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
+ LP + L +L L IS N LE +P+ IG KL+ L + N L +PE +G
Sbjct: 232 LERLPEE--ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECE 289
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE 660
+L L N L +LP S+ + L LN + N + LP+
Sbjct: 290 SLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPK 329
Score = 117 bits (292), Expect = 5e-26
Identities = 83/268 (30%), Positives = 133/268 (49%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+ LP L L++L L N++ LP E+ N + L L + N + +P+S+S C
Sbjct: 46 NQLRELPEQFFQLV-KLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFC 104
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L++ D N L +P +L NLT L + ++ + + I NL L +L LREN +
Sbjct: 105 KALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLT 164
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP + L +L L+ LD+ +N + LPE+IG L L L N+L +P+ IGNL L
Sbjct: 165 YLPDS--LTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSF 726
+ N L LP +S L +L N + +P+G + L +S + + +N +
Sbjct: 223 LCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDG-IGKLKKLSILKVDQNRLTQL 281
Query: 727 PLGGPQQFASTQTLNLDHNQITQIPFGI 810
P + S L L NQ+ +P I
Sbjct: 282 P-EAVGECESLTELVLTENQLLTLPKSI 308
Score = 112 bits (280), Expect = 1e-24
Identities = 76/260 (29%), Positives = 132/260 (50%)
Frame = +1
Query: 22 LPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRI 201
+P I A +L+EL L +N+L LP + LV L L L +N + LP ++ L
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
Query: 202 LDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSN 381
LD+ N++ EIP + L N + + + L+ L L++ + ++ LP N
Sbjct: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
Query: 382 PGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGL 561
G L NL +L++ N L LP+++ +L L+L +NE+ ++PE+IG L L+ L
Sbjct: 147 IG--NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWL 204
Query: 562 RYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGP 741
N L+ LP + + L L+ N + +LPE ++ L ++ + +S+N + P G
Sbjct: 205 DGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGLTSLTDLVISQNLLETIP-DGI 262
Query: 742 QQFASTQTLNLDHNQITQIP 801
+ L +D N++TQ+P
Sbjct: 263 GKLKKLSILKVDQNRLTQLP 282
Score = 88.2 bits (217), Expect = 3e-17
Identities = 59/202 (29%), Positives = 95/202 (47%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q++ LP I +L NL L + N+L LP E+ L +L L++ +N + +PD + +
Sbjct: 207 NQLSELPQEIGNLK-NLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKL 265
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L IL + N+L ++P V + +LT L+L N++ + + I L+KL NL NK
Sbjct: 266 KKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK-- 323
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
L LP+ IG C LT ++ N L IP + T L
Sbjct: 324 -----------------------LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360
Query: 547 ERFGLRYNHLTSLPASLSFCRM 612
+ N L LP SL+ ++
Sbjct: 361 HVLDVAGNRLLHLPLSLTALKL 382
>sp|O61967|LAP1_CAEEL Lap1 protein (Lethal protein 413)
Length = 699
Score = 131 bits (330), Expect = 2e-30
Identities = 85/237 (35%), Positives = 126/237 (53%)
Frame = +1
Query: 13 ITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRL 192
+ ++P +I +L L+EL L N+L LP E+G L +L + N +T+LPDS+S CR+
Sbjct: 163 LRTIPLSIVEL-RKLEELDLGQNELEALPAEIGKLTSLREFYVDINSLTSLPDSISGCRM 221
Query: 193 LRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLL 372
L LD+ N++ +P + ++ NLT L + N I E+ L++LQ L N + L
Sbjct: 222 LDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNL 281
Query: 373 PSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALER 552
S G K +L L + N L LP+ IG +LTTLN+ N L IP+TIGN +L
Sbjct: 282 TSEIG--KCQSLTELYLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTV 339
Query: 553 FGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSS 723
LR N LT LP ++ C L L+ N + LP + L + ++ LS N S
Sbjct: 340 LSLRQNILTELPMTIGKCENLTVLDVASNKLPHLPFTVKV-LYKLQALWLSENQTQS 395
Score = 121 bits (303), Expect = 3e-27
Identities = 86/260 (33%), Positives = 128/260 (49%), Gaps = 6/260 (2%)
Frame = +1
Query: 28 SNIKDLAH------NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCR 189
+NIK+L H +L+ L + N+L LP E+GNL L L L N + LPD++ C+
Sbjct: 46 NNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCK 105
Query: 190 LLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRL 369
LL L++ N +P + + ++T L +L E + L
Sbjct: 106 LLTTLNLSSNPFTRLPETICECSSITIL-----------------------SLNETSLTL 142
Query: 370 LPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALE 549
LPSN G L NL+ L+ N L +P +I KL L+L NEL+++P IG LT+L
Sbjct: 143 LPSNIG--SLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLR 200
Query: 550 RFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFP 729
F + N LTSLP S+S CRML +L+ N I +LPE L + +++ + +S N P
Sbjct: 201 EFYVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPEN-LGRMPNLTDLNISINEIIELP 259
Query: 730 LGGPQQFASTQTLNLDHNQI 789
+ Q L D N +
Sbjct: 260 -SSFGELKRLQMLKADRNSL 278
Score = 84.7 bits (208), Expect = 3e-16
Identities = 56/203 (27%), Positives = 98/203 (48%)
Frame = +1
Query: 202 LDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSN 381
+D + L IP +F+ L L L N I+E+D + +L L+ L + +N++ +LP+
Sbjct: 18 IDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAE 77
Query: 382 PGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGL 561
G L L L+++ N + LP+ + +C LTTLNL N +PETI +++ L
Sbjct: 78 IG--NLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSL 135
Query: 562 RYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGP 741
LT LP+++ L L N + +P ++ L + + L +N + P
Sbjct: 136 NETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIV-ELRKLEELDLGQNELEALP-AEI 193
Query: 742 QQFASTQTLNLDHNQITQIPFGI 810
+ S + +D N +T +P I
Sbjct: 194 GKLTSLREFYVDINSLTSLPDSI 216
Score = 59.7 bits (143), Expect = 1e-08
Identities = 34/97 (35%), Positives = 55/97 (56%)
Frame = +1
Query: 13 ITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRL 192
+T LP I DL L L + N L ++P+ +GN +L +L L++N +T LP ++ +C
Sbjct: 301 LTDLPDTIGDL-RQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTIGKCEN 359
Query: 193 LRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREV 303
L +LD+ NKL +P V L+ L L L N+ + +
Sbjct: 360 LTVLDVASNKLPHLPFTVKVLYKLQALWLSENQTQSI 396
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/135 (28%), Positives = 68/135 (50%)
Frame = +1
Query: 406 LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
+ ++D S ++L+ +P I KL LNL N +K + + +L L + N L L
Sbjct: 15 VDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVL 74
Query: 586 PASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGPQQFASTQT 765
PA + L ELN N+I++LP+ + + ++++ LS N F+ P + +S
Sbjct: 75 PAEIGNLTQLIELNLNRNSIAKLPDTMQNCKL-LTTLNLSSNPFTRLP-ETICECSSITI 132
Query: 766 LNLDHNQITQIPFGI 810
L+L+ +T +P I
Sbjct: 133 LSLNETSLTLLPSNI 147
>sp|Q7KRY7|LAP4_DROME LAP4 protein (Scribble protein) (Smell-impaired protein)
Length = 1851
Score = 128 bits (321), Expect = 2e-29
Identities = 87/274 (31%), Positives = 143/274 (52%), Gaps = 2/274 (0%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + I LPS L NL L L L LP + G+L LE L L+EN + LP+++S
Sbjct: 114 SSNPIPKLPSGFSQLK-NLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETIS 172
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
Q L+ LD+ N++ ++PP++ L L L L N+++ + E+ L KL L + EN+
Sbjct: 173 QLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENR 232
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
+ LP+ + LV+L LD++ N LE LP+ I ++LT L L N L+ + +T+GN
Sbjct: 233 LEELPNE--ISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCE 290
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
++ L N L+ LPAS+ L LN + N + LP + ++ ++L N
Sbjct: 291 NMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLE-IGQCANLGVLSLRDNKLK 349
Query: 721 SFPLGGPQQFAST--QTLNLDHNQITQIPFGILS 816
P P+ T L++ NQ+ +P+ +++
Sbjct: 350 KLP---PELGNCTVLHVLDVSGNQLLYLPYSLVN 380
Score = 114 bits (286), Expect = 3e-25
Identities = 81/290 (27%), Positives = 135/290 (46%), Gaps = 22/290 (7%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+ I LP N L H L++L L N++ LP ++ N NL L + N + +PD +
Sbjct: 47 NHIRDLPKNFFRL-HRLRKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHL 105
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L++ D N + ++P +L NLT L L + + + +L +L++L LREN ++
Sbjct: 106 QSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLK 165
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP + +L L+ LD+ N +E LP +G+ L L L HN+L+ +P +G LT L
Sbjct: 166 HLPET--ISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKL 223
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-------------------- 666
+ N L LP +S L +L+ N + LP+G+
Sbjct: 224 TYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLN 283
Query: 667 --LTHLIHVSSITLSRNYFSSFPLGGPQQFASTQTLNLDHNQITQIPFGI 810
L + ++ + L+ N+ S P Q LN+D N + +P I
Sbjct: 284 DTLGNCENMQELILTENFLSELP-ASIGQMTKLNNLNVDRNALEYLPLEI 332
Score = 106 bits (264), Expect = 9e-23
Identities = 73/262 (27%), Positives = 126/262 (48%)
Frame = +1
Query: 13 ITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRL 192
+ +P I + L+EL+L +N + +LP L L L L +N + LP +
Sbjct: 25 LPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFEN 84
Query: 193 LRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLL 372
L LD+ N + +IP + L +L N I ++ + L+ L L L + + L
Sbjct: 85 LVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTL 144
Query: 373 PSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALER 552
P++ G L L++L++ N L+ LPE I TKL L+L NE++ +P +G L L
Sbjct: 145 PADFG--SLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHE 202
Query: 553 FGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPL 732
L +N L LP L L L+ N + +LP ++ L+ ++ + L++N + P
Sbjct: 203 LWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNE-ISGLVSLTDLDLAQNLLEALP- 260
Query: 733 GGPQQFASTQTLNLDHNQITQI 798
G + + L LD N++ ++
Sbjct: 261 DGIAKLSRLTILKLDQNRLQRL 282
Score = 91.3 bits (225), Expect = 3e-18
Identities = 58/177 (32%), Positives = 92/177 (51%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+ LP + L L L + N+L LPNE+ LV+L L L +N + ALPD +++
Sbjct: 208 NQLQRLPPEL-GLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKL 266
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
L IL + N+L + + N+ L+L N + E+ I + KL NL + N +
Sbjct: 267 SRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALE 326
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNL 537
LP G + NL L + N L+ LP +G+CT L L++ N+L +P ++ NL
Sbjct: 327 YLPLEIG--QCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL 381
Score = 52.0 bits (123), Expect = 2e-06
Identities = 38/123 (30%), Positives = 61/123 (49%), Gaps = 1/123 (0%)
Frame = +1
Query: 52 NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
N++EL L N L LP +G + L L + N + LP + QC L +L +R NKL +
Sbjct: 291 NMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKK 350
Query: 232 IPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR-LLPSNPGLEKLVNL 408
+PP + L L + N++ + + NL+ L+ + L EN+ + LL P +
Sbjct: 351 LPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQ-LKAVWLSENQSQPLLTFQPDTDAETGE 409
Query: 409 QTL 417
Q L
Sbjct: 410 QVL 412
>sp|Q96NW7|LRRC7_HUMAN Leucine-rich repeat-containing protein 7 (LAP1 protein)
(Densin-180)
Length = 1537
Score = 125 bits (313), Expect = 2e-28
Identities = 87/269 (32%), Positives = 138/269 (51%), Gaps = 1/269 (0%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + I+ LP L NL +LYL L LP G LV L IL L+EN + LP S+
Sbjct: 123 SVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH 181
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
+ L LD+ +N+ E+P + ++ NL L + N ++ + I L+ L L + +N+
Sbjct: 182 KLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNR 241
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
I + + + L+ L +S N L+ LP++IG KLTTL + N+L +P TIGNL+
Sbjct: 242 IETVDMD--ISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-LTHLIHVSSITLSRNYF 717
LE F N L SLP+++ + L L + N + +LP + + V S+ ++ F
Sbjct: 300 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEF 359
Query: 718 SSFPLGGPQQFASTQTLNLDHNQITQIPF 804
+G Q + LNL N++ +PF
Sbjct: 360 LPEEIG---QMQKLRVLNLSDNRLKNLPF 385
Score = 109 bits (273), Expect = 9e-24
Identities = 78/267 (29%), Positives = 126/267 (47%), Gaps = 2/267 (0%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+QI LP + + L++L + N L NLP + +LVNL+ L + +N V P+++ C
Sbjct: 56 NQIEELPKQLFN-CQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCC 114
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L I++ N + ++P +L NLT L L + + L KL+ L LREN ++
Sbjct: 115 KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLK 174
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP + + KL L+ LD+ +N LPE + L L + +N L+ +P +IG L L
Sbjct: 175 TLPKS--MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKML 232
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE--GLLTHLIHVSSITLSRNYFS 720
+ N + ++ +S C L +L N + QLP+ GLL L
Sbjct: 233 VYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL-------------- 278
Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIP 801
TL +D NQ+T +P
Sbjct: 279 -------------TTLKVDDNQLTMLP 292
Score = 97.4 bits (241), Expect = 4e-20
Identities = 65/207 (31%), Positives = 101/207 (48%)
Frame = +1
Query: 34 IKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIR 213
+ D NL+EL++ +N L LP +G L L L + +N + + +S C L L +
Sbjct: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLS 261
Query: 214 HNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSNPGLE 393
N L ++P + L LT L + N++ + I NL L+ N++ LPS G
Sbjct: 262 SNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGY- 320
Query: 394 KLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNH 573
L +L+TL + N L LP IG C +T ++L+ N+L+ +PE IG + L L N
Sbjct: 321 -LHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNR 379
Query: 574 LTSLPASLSFCRMLCELNTEGNNISQL 654
L +LP S + + L L N L
Sbjct: 380 LKNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 60.8 bits (146), Expect = 5e-09
Identities = 37/122 (30%), Positives = 68/122 (55%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+Q+T LP+ I +L+ L+E N+L +LP+ +G L +L L + EN + LP + C
Sbjct: 286 NQLTMLPNTIGNLSL-LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELpreIGSC 344
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ + ++ +R NKL +P + ++ L L L NR++ + L++L L L +N+ +
Sbjct: 345 KNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSK 404
Query: 367 LL 372
L
Sbjct: 405 AL 406
Score = 60.1 bits (144), Expect = 8e-09
Identities = 34/132 (25%), Positives = 66/132 (50%)
Frame = +1
Query: 406 LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
L+ L + N +E LP+ + +C L L++ N+L ++P TI +L L+ + N +
Sbjct: 48 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107
Query: 586 PASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGPQQFASTQT 765
P ++ C+ L + N IS+LP+G T L++++ + L+ + P + +
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDG-FTQLLNLTQLYLNDAFLEFLP-ANFGRLVKLRI 165
Query: 766 LNLDHNQITQIP 801
L L N + +P
Sbjct: 166 LELRENHLKTLP 177
Score = 37.0 bits (84), Expect = 0.070
Identities = 22/69 (31%), Positives = 36/69 (52%)
Frame = +1
Query: 52 NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
N+ + L SNKL LP E+G + L +L L +N + LP S ++ + L L + N+
Sbjct: 346 NVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 405
Query: 232 IPPFVFKLH 258
+ P + H
Sbjct: 406 LIPLQTEAH 414
>sp|P70587|LRRC7_RAT Leucine-rich repeat-containing protein 7 (LAP1 protein)
(Densin-180)
Length = 1495
Score = 124 bits (312), Expect = 3e-28
Identities = 87/269 (32%), Positives = 137/269 (50%), Gaps = 1/269 (0%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + I+ LP L NL +LYL L LP G LV L IL L+EN + LP S+
Sbjct: 128 SVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH 186
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
+ L LD+ +N+ E+P + ++ NL L + N ++ + I L+ L L + +N+
Sbjct: 187 KLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNR 246
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
I + + + L+ L +S N L+ LP++IG KLTTL + N+L +P TIGNL+
Sbjct: 247 IETVDMD--ISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 304
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-LTHLIHVSSITLSRNYF 717
LE F N L SLP ++ + L L + N + +LP + + V S+ ++ F
Sbjct: 305 LLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEF 364
Query: 718 SSFPLGGPQQFASTQTLNLDHNQITQIPF 804
+G Q + LNL N++ +PF
Sbjct: 365 LPEEIG---QMQRLRVLNLSDNRLKNLPF 390
Score = 108 bits (271), Expect = 1e-23
Identities = 77/267 (28%), Positives = 126/267 (47%), Gaps = 2/267 (0%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+QI LP + + L++L + N L +LP + +LVNL+ L + +N V P+++ C
Sbjct: 61 NQIEELPKQLFN-CQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCC 119
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L I++ N + ++P +L NLT L L + + L KL+ L LREN ++
Sbjct: 120 KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLK 179
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP + + KL L+ LD+ +N LPE + L L + +N L+ +P +IG L L
Sbjct: 180 TLPKS--MHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKML 237
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE--GLLTHLIHVSSITLSRNYFS 720
+ N + ++ +S C L +L N + QLP+ GLL L
Sbjct: 238 VYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL-------------- 283
Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIP 801
TL +D NQ+T +P
Sbjct: 284 -------------TTLKVDDNQLTMLP 297
Score = 97.4 bits (241), Expect = 4e-20
Identities = 66/216 (30%), Positives = 106/216 (49%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
++ + LP + D NL+EL++ +N L LP +G L L L + +N + + +S C
Sbjct: 199 NEFSELPE-VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGC 257
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
L L + N L ++P + L LT L + N++ + I NL L+ N++
Sbjct: 258 EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 317
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP P + L +L+TL + N L LP IG C +T ++L+ N+L+ +PE IG + L
Sbjct: 318 SLP--PTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEFLPEEIGQMQRL 375
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQL 654
L N L +LP S + + L L N L
Sbjct: 376 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 411
Score = 83.6 bits (205), Expect = 7e-16
Identities = 54/172 (31%), Positives = 94/172 (54%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
SK++I ++ +I L++L L SN L LP+ +G L L L + +N +T LP+++
Sbjct: 243 SKNRIETVDMDISG-CEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
LL D N+L +PP + LH+L L + N + E+ +EI + + + ++LR NK
Sbjct: 302 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNK 361
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSI 516
+ LP G ++ L+ L++S N L+ LP + +L L L N+ K++
Sbjct: 362 LEFLPEEIG--QMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 411
Score = 37.0 bits (84), Expect = 0.070
Identities = 22/69 (31%), Positives = 36/69 (52%)
Frame = +1
Query: 52 NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
N+ + L SNKL LP E+G + L +L L +N + LP S ++ + L L + N+
Sbjct: 351 NVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 410
Query: 232 IPPFVFKLH 258
+ P + H
Sbjct: 411 LIPLQTEAH 419
>sp|Q80TE7|LRRC7_MOUSE Leucine-rich repeat-containing protein 7 (LAP1 protein)
(Densin-180)
Length = 1490
Score = 124 bits (312), Expect = 3e-28
Identities = 87/269 (32%), Positives = 137/269 (50%), Gaps = 1/269 (0%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + I+ LP L NL +LYL L LP G LV L IL L+EN + LP S+
Sbjct: 123 SVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH 181
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
+ L LD+ +N+ E+P + ++ NL L + N ++ + I L+ L L + +N+
Sbjct: 182 KLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNR 241
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
I + + + L+ L +S N L+ LP++IG KLTTL + N+L +P TIGNL+
Sbjct: 242 IETVDMD--ISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-LTHLIHVSSITLSRNYF 717
LE F N L SLP ++ + L L + N + +LP + + V S+ ++ F
Sbjct: 300 LLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEF 359
Query: 718 SSFPLGGPQQFASTQTLNLDHNQITQIPF 804
+G Q + LNL N++ +PF
Sbjct: 360 LPEEIG---QMQRLRVLNLSDNRLKNLPF 385
Score = 108 bits (271), Expect = 1e-23
Identities = 77/267 (28%), Positives = 126/267 (47%), Gaps = 2/267 (0%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+QI LP + + L++L + N L +LP + +LVNL+ L + +N V P+++ C
Sbjct: 56 NQIEELPKQLFN-CQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCC 114
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
+ L I++ N + ++P +L NLT L L + + L KL+ L LREN ++
Sbjct: 115 KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLK 174
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP + + KL L+ LD+ +N LPE + L L + +N L+ +P +IG L L
Sbjct: 175 TLPKS--MHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKML 232
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE--GLLTHLIHVSSITLSRNYFS 720
+ N + ++ +S C L +L N + QLP+ GLL L
Sbjct: 233 VYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL-------------- 278
Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIP 801
TL +D NQ+T +P
Sbjct: 279 -------------TTLKVDDNQLTMLP 292
Score = 97.4 bits (241), Expect = 4e-20
Identities = 66/216 (30%), Positives = 106/216 (49%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
++ + LP + D NL+EL++ +N L LP +G L L L + +N + + +S C
Sbjct: 194 NEFSELPE-VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGC 252
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
L L + N L ++P + L LT L + N++ + I NL L+ N++
Sbjct: 253 EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 312
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LP P + L +L+TL + N L LP IG C +T ++L+ N+L+ +PE IG + L
Sbjct: 313 SLP--PTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEFLPEEIGQMQRL 370
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQL 654
L N L +LP S + + L L N L
Sbjct: 371 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 83.6 bits (205), Expect = 7e-16
Identities = 54/172 (31%), Positives = 94/172 (54%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
SK++I ++ +I L++L L SN L LP+ +G L L L + +N +T LP+++
Sbjct: 238 SKNRIETVDMDISG-CEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 296
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
LL D N+L +PP + LH+L L + N + E+ +EI + + + ++LR NK
Sbjct: 297 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNK 356
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSI 516
+ LP G ++ L+ L++S N L+ LP + +L L L N+ K++
Sbjct: 357 LEFLPEEIG--QMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 37.0 bits (84), Expect = 0.070
Identities = 22/69 (31%), Positives = 36/69 (52%)
Frame = +1
Query: 52 NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
N+ + L SNKL LP E+G + L +L L +N + LP S ++ + L L + N+
Sbjct: 346 NVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 405
Query: 232 IPPFVFKLH 258
+ P + H
Sbjct: 406 LIPLQTEAH 414
>sp|Q96RT1|LAP2_HUMAN LAP2 protein (Erbb2-interacting protein) (Erbin) (Densin-180-like
protein)
Length = 1412
Score = 123 bits (309), Expect = 6e-28
Identities = 84/272 (30%), Positives = 133/272 (48%), Gaps = 2/272 (0%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + +P I L+ELYL +N++ LP +L N +L L L +N +T LP S++
Sbjct: 30 SHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA 89
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
LR LD+ N + E P + LT + N I ++ + L L L L +
Sbjct: 90 NLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAF 149
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
+ LP+N G +L LQ L++ N L+MLP+ + T+L L+L NE +PE + L+
Sbjct: 150 LEFLPANFG--RLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLS 207
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
L+ F + N LT +P + + L L+ NNI + EG+ T ++ + LS N
Sbjct: 208 GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST-CENLQDLLLSSNSLQ 266
Query: 721 SFP--LGGPQQFASTQTLNLDHNQITQIPFGI 810
P +G + TL +D NQ+ +P I
Sbjct: 267 QLPETIG---SLKNITTLKIDENQLMYLPDSI 295
Score = 120 bits (301), Expect = 5e-27
Identities = 81/270 (30%), Positives = 138/270 (51%), Gaps = 2/270 (0%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + I+ LP L NL +LYL L LP G L L+IL L+EN + LP +++
Sbjct: 123 SVNPISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMN 181
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
+ L LD+ N+ E+P + +L L + NR+ + I +L++L L + +N
Sbjct: 182 RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNN 241
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
I ++ G+ NLQ L +S N L+ LPE IG +TTL + N+L +P++IG L
Sbjct: 242 IEMVEE--GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299
Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
++E +N + +LP+S+ L + N + QLP + + +++ + L N
Sbjct: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK-NITVLFLHSNKLE 358
Query: 721 SFP--LGGPQQFASTQTLNLDHNQITQIPF 804
+ P +G Q+ + +NL N++ +PF
Sbjct: 359 TLPEEMGDMQKL---KVINLSDNRLKNLPF 385
Score = 114 bits (286), Expect = 3e-25
Identities = 76/270 (28%), Positives = 133/270 (49%), Gaps = 2/270 (0%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
+QI LP + + +L +L L N L LP + NL+NL L + +N + P+++ C
Sbjct: 56 NQIEELPKQLFN-CQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
++L I++ N + ++P +L NLT L L + + L KLQ L LREN+++
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLK 174
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
+LP + +L L+ LD+ N +PE + + L + N L IP IG+L L
Sbjct: 175 MLPKT--MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSF 726
+ N++ + +S C L +L N++ QLPE + L +++++ + N
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE-TIGSLKNITTLKIDENQLMYL 291
Query: 727 P--LGGPQQFASTQTLNLDHNQITQIPFGI 810
P +GG S + L+ N++ +P I
Sbjct: 292 PDSIGG---LISVEELDCSFNEVEALPSSI 318
Score = 103 bits (257), Expect = 6e-22
Identities = 63/216 (29%), Positives = 114/216 (52%)
Frame = +1
Query: 7 SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
++ T +P ++ L+ LKE ++ +N+L +P +G+L L L + +N + + + +S C
Sbjct: 194 NEFTEVPEVLEQLS-GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252
Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
L+ L + N L ++P + L N+T L + N++ + I L ++ L N++
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVE 312
Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
LPS+ G +L NL+T HN+L+ LP IG +T L L N+L+++PE +G++ L
Sbjct: 313 ALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370
Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQL 654
+ L N L +LP S + + L + N L
Sbjct: 371 KVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406
Score = 76.3 bits (186), Expect = 1e-13
Identities = 47/149 (31%), Positives = 81/149 (54%)
Frame = +1
Query: 1 SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
S + + LP I L N+ L + N+L+ LP+ +G L+++E L N V ALP S+
Sbjct: 261 SSNSLQQLPETIGSLK-NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319
Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
Q LR HN L ++PP + N+T L L N++ + +E+ +++KL+ + L +N+
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379
Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEML 447
++ LP + KL L + +S N + L
Sbjct: 380 LKNLPFS--FTKLQQLTAMWLSDNQSKPL 406
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,272,706
Number of Sequences: 369166
Number of extensions: 2256705
Number of successful extensions: 9293
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6708
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7898
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)