Planaria EST Database


DrC_02778

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_02778
         (857 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q9UQ13|SHOC2_HUMAN  Leucine-rich repeat protein SHOC-2 (R...   303   3e-82
sp|O88520|SHOC2_MOUSE  Leucine-rich repeat protein SHOC-2 (R...   300   4e-81
sp|Q80VQ1|LRRC1_MOUSE  Leucine-rich repeat-containing protein 1   134   4e-31
sp|Q9BTT6|LRRC1_HUMAN  Leucine-rich repeat-containing protei...   132   1e-30
sp|O61967|LAP1_CAEEL  Lap1 protein (Lethal protein 413)           131   2e-30
sp|Q7KRY7|LAP4_DROME  LAP4 protein (Scribble protein) (Smell...   128   2e-29
sp|Q96NW7|LRRC7_HUMAN  Leucine-rich repeat-containing protei...   125   2e-28
sp|P70587|LRRC7_RAT  Leucine-rich repeat-containing protein ...   124   3e-28
sp|Q80TE7|LRRC7_MOUSE  Leucine-rich repeat-containing protei...   124   3e-28
sp|Q96RT1|LAP2_HUMAN  LAP2 protein (Erbb2-interacting protei...   123   6e-28
>sp|Q9UQ13|SHOC2_HUMAN Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8)
          Length = 582

 Score =  303 bits (777), Expect = 3e-82
 Identities = 157/274 (57%), Positives = 207/274 (75%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           SK  I  LPS+IK+L   L ELYLYSNKL +LP E+G LVNL  L L EN +T+LPDSL 
Sbjct: 108 SKRSIHILPSSIKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLD 166

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
             + LR+LD+RHNKL EIP  V++L +LT L LRFNRI  V+++I NL KL  L++RENK
Sbjct: 167 NLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENK 226

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           I+ LP+  G  +L NL TLD++HN LE LP+ IG+CT++T L+LQHNEL  +P+TIGNL+
Sbjct: 227 IKQLPAEIG--ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLS 284

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
           +L R GLRYN L+++P SL+ C  L ELN E NNIS LPE LL+ L+ ++S+TL+RN F 
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344

Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIPFGILSRA 822
            +P+GGP QF++  +LN++HN+I +IPFGI SRA
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378

 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 76/269 (28%), Positives = 130/269 (48%), Gaps = 47/269 (17%)
 Frame = +1

Query: 7    SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
            +Q+  LP  I +    +  L L  N+L++LP+ +GNL +L  L L+ N ++A+P SL++C
Sbjct: 248  NQLEHLPKEIGNCTQ-ITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKC 306

Query: 187  RLLRILDIRHNKLCEIPPFVF----KLHNLT---------------------HLLLRFNR 291
              L  L++ +N +  +P  +     KL++LT                      L +  NR
Sbjct: 307  SALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNR 366

Query: 292  IREVDQEIANLEK-LQNLTLRENKIRLLPSNPG---------------------LEKLVN 405
            I ++   I +  K L  L +++N++  LP + G                     +  LV+
Sbjct: 367  INKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVS 426

Query: 406  LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
            L+ L +S+N L+ LP  +G+  KL  L+L+ N+L+S+P  I  L  L++  L  N LT+L
Sbjct: 427  LEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTL 486

Query: 586  PASLSFCRMLCELNTEGNNISQLPEGLLT 672
            P  +     L  L    N ++ LPE + T
Sbjct: 487  PRGIGHLTNLTHLGLGENLLTHLPEEIGT 515

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 59/175 (33%), Positives = 98/175 (56%), Gaps = 1/175 (0%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q+TSLP +      ++ EL L +N+L  +P ++  LV+LE+L+L  N +  LP  L   
Sbjct: 389 NQLTSLPLDFGTWT-SMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNL 447

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           R LR LD+  NKL  +P  +  L +L  L+L  N++  + + I +L  L +L L EN + 
Sbjct: 448 RKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLT 507

Query: 367 LLPSNPGLEKLVNLQTLDISHN-HLEMLPEAIGHCTKLTTLNLQHNELKSIPETI 528
            LP   G   L NL+ L ++ N +L  LP  +  C+KL+ +++++  L  +P  I
Sbjct: 508 HLPEEIG--TLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 46/159 (28%), Positives = 77/159 (48%)
 Frame = +1

Query: 325 EKLQNLTLRENKIRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNE 504
           E    L L +  I +LPS+  +++L  L  L +  N L+ LP  +G    L TL L  N 
Sbjct: 100 ENSMRLDLSKRSIHILPSS--IKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157

Query: 505 LKSIPETIGNLTALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIH 684
           L S+P+++ NL  L    LR+N L  +P+ +     L  L    N I+ + E  + +L  
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV-EKDIKNLSK 216

Query: 685 VSSITLSRNYFSSFPLGGPQQFASTQTLNLDHNQITQIP 801
           +S +++  N     P     +  +  TL++ HNQ+  +P
Sbjct: 217 LSMLSIRENKIKQLP-AEIGELCNLITLDVAHNQLEHLP 254
>sp|O88520|SHOC2_MOUSE Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8)
          Length = 582

 Score =  300 bits (767), Expect = 4e-81
 Identities = 154/274 (56%), Positives = 206/274 (75%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           SK  I  LP ++K+L   L ELYLYSNKL +LP E+G LVNL  L L EN +T+LPDSL 
Sbjct: 108 SKRSIHILPPSVKELTQ-LTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLD 166

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
             + LR+LD+RHNKL EIP  V++L +LT L LRFNRI  V+++I NL KL  L++RENK
Sbjct: 167 NLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLPKLSMLSIRENK 226

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           I+ LP+  G  +L NL TLD++HN LE LP+ IG+CT++T L+LQHN+L  +P+TIGNL+
Sbjct: 227 IKQLPAEIG--ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNDLLDLPDTIGNLS 284

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
           +L R GLRYN L+++P SL+ C  L ELN E NNIS LPE LL+ L+ ++S+TL+RN F 
Sbjct: 285 SLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344

Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIPFGILSRA 822
            +P+GGP QF++  +LN++HN+I +IPFGI SRA
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRA 378

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 75/269 (27%), Positives = 129/269 (47%), Gaps = 47/269 (17%)
 Frame = +1

Query: 7    SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
            +Q+  LP  I +    +  L L  N L++LP+ +GNL +L  L L+ N ++A+P SL++C
Sbjct: 248  NQLEHLPKEIGNCTQ-ITNLDLQHNDLLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKC 306

Query: 187  RLLRILDIRHNKLCEIPPFVF----KLHNLT---------------------HLLLRFNR 291
              L  L++ +N +  +P  +     KL++LT                      L +  NR
Sbjct: 307  SALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNR 366

Query: 292  IREVDQEIANLEK-LQNLTLRENKIRLLPSNPG---------------------LEKLVN 405
            I ++   I +  K L  L +++N++  LP + G                     +  LV+
Sbjct: 367  INKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVS 426

Query: 406  LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
            L+ L +S+N L+ LP  +G+  KL  L+L+ N+L+S+P  I  L  L++  L  N L++L
Sbjct: 427  LEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTL 486

Query: 586  PASLSFCRMLCELNTEGNNISQLPEGLLT 672
            P  +     L  L    N ++ LPE + T
Sbjct: 487  PRGIGHLTNLTHLGLGENLLTHLPEEIGT 515

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 59/175 (33%), Positives = 98/175 (56%), Gaps = 1/175 (0%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q+TSLP +      ++ EL L +N+L  +P ++  LV+LE+L+L  N +  LP  L   
Sbjct: 389 NQLTSLPLDFGTWT-SMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNL 447

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           R LR LD+  NKL  +P  +  L +L  L+L  N++  + + I +L  L +L L EN + 
Sbjct: 448 RKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLSTLPRGIGHLTNLTHLGLGENLLT 507

Query: 367 LLPSNPGLEKLVNLQTLDISHN-HLEMLPEAIGHCTKLTTLNLQHNELKSIPETI 528
            LP   G   L NL+ L ++ N +L  LP  +  C+KL+ +++++  L  +P  I
Sbjct: 508 HLPEEIG--TLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 46/159 (28%), Positives = 76/159 (47%)
 Frame = +1

Query: 325 EKLQNLTLRENKIRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNE 504
           E    L L +  I +LP  P +++L  L  L +  N L+ LP  +G    L TL L  N 
Sbjct: 100 ENSMRLDLSKRSIHILP--PSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157

Query: 505 LKSIPETIGNLTALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIH 684
           L S+P+++ NL  L    LR+N L  +P+ +     L  L    N I+ + E  + +L  
Sbjct: 158 LTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTV-EKDIKNLPK 216

Query: 685 VSSITLSRNYFSSFPLGGPQQFASTQTLNLDHNQITQIP 801
           +S +++  N     P     +  +  TL++ HNQ+  +P
Sbjct: 217 LSMLSIRENKIKQLP-AEIGELCNLITLDVAHNQLEHLP 254
>sp|Q80VQ1|LRRC1_MOUSE Leucine-rich repeat-containing protein 1
          Length = 524

 Score =  134 bits (336), Expect = 4e-31
 Identities = 85/220 (38%), Positives = 121/220 (55%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + +T LP +  +L  NL  L +    L +LP  +GNL NL  L L+EN +T LPDSL+
Sbjct: 113 SGNPLTRLPESFPEL-QNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLT 171

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           Q R L  LD+ +N++  +P  +  L +L  L L  N++ E+ QEI NL+ L  L + EN+
Sbjct: 172 QLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENR 231

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           +  LP    +  L +L  L IS N LE +PE IG   KL+ L L  N L  +PE IG+  
Sbjct: 232 LERLPEE--ISGLTSLTYLVISQNLLETIPEGIGKLKKLSILKLDQNRLTQLPEAIGDCE 289

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE 660
            L    L  N L +LP S+   + L  LN + N +  LP+
Sbjct: 290 NLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLVSLPK 329

 Score =  114 bits (285), Expect = 3e-25
 Identities = 77/241 (31%), Positives = 122/241 (50%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q+  LP     L   L++L L  N++  LP E+ N + L  L +  N +  +P+S++ C
Sbjct: 46  NQLRELPEQFFQLV-KLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNDIPEIPESIAFC 104

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L++ D   N L  +P    +L NLT L +    ++ + + I NL  L +L LREN + 
Sbjct: 105 KALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLT 164

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP +  L +L  L+ LD+ +N +  LPE+IG    L  L L  N+L  +P+ IGNL  L
Sbjct: 165 YLPDS--LTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSF 726
               +  N L  LP  +S    L  L    N +  +PEG +  L  +S + L +N  +  
Sbjct: 223 LCLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEG-IGKLKKLSILKLDQNRLTQL 281

Query: 727 P 729
           P
Sbjct: 282 P 282

 Score =  112 bits (279), Expect = 2e-24
 Identities = 78/263 (29%), Positives = 132/263 (50%)
 Frame = +1

Query: 22  LPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRI 201
           +P  I   A +L+EL L +N+L  LP +   LV L  L L +N +  LP  ++    L  
Sbjct: 27  VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86

Query: 202 LDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSN 381
           LD+  N + EIP  +     L       N +  + +    L+ L  L++ +  ++ LP N
Sbjct: 87  LDVSRNDIPEIPESIAFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146

Query: 382 PGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGL 561
            G   L NL +L++  N L  LP+++    +L  L+L +NE+ ++PE+IG L  L+   L
Sbjct: 147 IG--NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWL 204

Query: 562 RYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGP 741
             N L+ LP  +   + L  L+   N + +LPE  ++ L  ++ + +S+N   + P  G 
Sbjct: 205 DGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGLTSLTYLVISQNLLETIP-EGI 262

Query: 742 QQFASTQTLNLDHNQITQIPFGI 810
            +      L LD N++TQ+P  I
Sbjct: 263 GKLKKLSILKLDQNRLTQLPEAI 285

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 54/177 (30%), Positives = 90/177 (50%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q++ LP  I +L  NL  L +  N+L  LP E+  L +L  L++ +N +  +P+ + + 
Sbjct: 207 NQLSELPQEIGNLK-NLLCLDVSENRLERLPEEISGLTSLTYLVISQNLLETIPEGIGKL 265

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L IL +  N+L ++P  +    NLT L+L  NR+  + + I  L+KL NL    NK+ 
Sbjct: 266 KKLSILKLDQNRLTQLPEAIGDCENLTELVLTENRLLTLPKSIGKLKKLSNLNADRNKLV 325

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNL 537
            LP   G     +L    I  N L  LP  +    +L  L++  N L  +P ++  L
Sbjct: 326 SLPKEIG--GCCSLTMFCIRDNRLTRLPAEVSQAVELHVLDVAGNRLHHLPLSLTTL 380
>sp|Q9BTT6|LRRC1_HUMAN Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein)
           (LANO adapter protein)
          Length = 524

 Score =  132 bits (332), Expect = 1e-30
 Identities = 82/220 (37%), Positives = 121/220 (55%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + +T LP +  +L  NL  L +    L +LP  +GNL NL  L L+EN +T LPDSL+
Sbjct: 113 SGNPLTRLPESFPEL-QNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLT 171

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           Q R L  LD+ +N++  +P  +  L +L  L L  N++ E+ QEI NL+ L  L + EN+
Sbjct: 172 QLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENR 231

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           +  LP    +  L +L  L IS N LE +P+ IG   KL+ L +  N L  +PE +G   
Sbjct: 232 LERLPEE--ISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECE 289

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE 660
           +L    L  N L +LP S+   + L  LN + N +  LP+
Sbjct: 290 SLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPK 329

 Score =  117 bits (292), Expect = 5e-26
 Identities = 83/268 (30%), Positives = 133/268 (49%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q+  LP     L   L++L L  N++  LP E+ N + L  L +  N +  +P+S+S C
Sbjct: 46  NQLRELPEQFFQLV-KLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFC 104

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L++ D   N L  +P    +L NLT L +    ++ + + I NL  L +L LREN + 
Sbjct: 105 KALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLT 164

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP +  L +L  L+ LD+ +N +  LPE+IG    L  L L  N+L  +P+ IGNL  L
Sbjct: 165 YLPDS--LTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNL 222

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSF 726
               +  N L  LP  +S    L +L    N +  +P+G +  L  +S + + +N  +  
Sbjct: 223 LCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDG-IGKLKKLSILKVDQNRLTQL 281

Query: 727 PLGGPQQFASTQTLNLDHNQITQIPFGI 810
           P     +  S   L L  NQ+  +P  I
Sbjct: 282 P-EAVGECESLTELVLTENQLLTLPKSI 308

 Score =  112 bits (280), Expect = 1e-24
 Identities = 76/260 (29%), Positives = 132/260 (50%)
 Frame = +1

Query: 22  LPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRI 201
           +P  I   A +L+EL L +N+L  LP +   LV L  L L +N +  LP  ++    L  
Sbjct: 27  VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86

Query: 202 LDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSN 381
           LD+  N++ EIP  +     L       N +  + +    L+ L  L++ +  ++ LP N
Sbjct: 87  LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146

Query: 382 PGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGL 561
            G   L NL +L++  N L  LP+++    +L  L+L +NE+ ++PE+IG L  L+   L
Sbjct: 147 IG--NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWL 204

Query: 562 RYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGP 741
             N L+ LP  +   + L  L+   N + +LPE  ++ L  ++ + +S+N   + P  G 
Sbjct: 205 DGNQLSELPQEIGNLKNLLCLDVSENRLERLPEE-ISGLTSLTDLVISQNLLETIP-DGI 262

Query: 742 QQFASTQTLNLDHNQITQIP 801
            +      L +D N++TQ+P
Sbjct: 263 GKLKKLSILKVDQNRLTQLP 282

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 59/202 (29%), Positives = 95/202 (47%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q++ LP  I +L  NL  L +  N+L  LP E+  L +L  L++ +N +  +PD + + 
Sbjct: 207 NQLSELPQEIGNLK-NLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKL 265

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L IL +  N+L ++P  V +  +LT L+L  N++  + + I  L+KL NL    NK  
Sbjct: 266 KKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK-- 323

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
                                  L  LP+ IG C  LT   ++ N L  IP  +   T L
Sbjct: 324 -----------------------LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATEL 360

Query: 547 ERFGLRYNHLTSLPASLSFCRM 612
               +  N L  LP SL+  ++
Sbjct: 361 HVLDVAGNRLLHLPLSLTALKL 382
>sp|O61967|LAP1_CAEEL Lap1 protein (Lethal protein 413)
          Length = 699

 Score =  131 bits (330), Expect = 2e-30
 Identities = 85/237 (35%), Positives = 126/237 (53%)
 Frame = +1

Query: 13  ITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRL 192
           + ++P +I +L   L+EL L  N+L  LP E+G L +L    +  N +T+LPDS+S CR+
Sbjct: 163 LRTIPLSIVEL-RKLEELDLGQNELEALPAEIGKLTSLREFYVDINSLTSLPDSISGCRM 221

Query: 193 LRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLL 372
           L  LD+  N++  +P  + ++ NLT L +  N I E+      L++LQ L    N +  L
Sbjct: 222 LDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNL 281

Query: 373 PSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALER 552
            S  G  K  +L  L +  N L  LP+ IG   +LTTLN+  N L  IP+TIGN  +L  
Sbjct: 282 TSEIG--KCQSLTELYLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTV 339

Query: 553 FGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSS 723
             LR N LT LP ++  C  L  L+   N +  LP  +   L  + ++ LS N   S
Sbjct: 340 LSLRQNILTELPMTIGKCENLTVLDVASNKLPHLPFTVKV-LYKLQALWLSENQTQS 395

 Score =  121 bits (303), Expect = 3e-27
 Identities = 86/260 (33%), Positives = 128/260 (49%), Gaps = 6/260 (2%)
 Frame = +1

Query: 28  SNIKDLAH------NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCR 189
           +NIK+L H      +L+ L +  N+L  LP E+GNL  L  L L  N +  LPD++  C+
Sbjct: 46  NNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCK 105

Query: 190 LLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRL 369
           LL  L++  N    +P  + +  ++T L                       +L E  + L
Sbjct: 106 LLTTLNLSSNPFTRLPETICECSSITIL-----------------------SLNETSLTL 142

Query: 370 LPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALE 549
           LPSN G   L NL+ L+   N L  +P +I    KL  L+L  NEL+++P  IG LT+L 
Sbjct: 143 LPSNIG--SLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLR 200

Query: 550 RFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFP 729
            F +  N LTSLP S+S CRML +L+   N I +LPE  L  + +++ + +S N     P
Sbjct: 201 EFYVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPEN-LGRMPNLTDLNISINEIIELP 259

Query: 730 LGGPQQFASTQTLNLDHNQI 789
                +    Q L  D N +
Sbjct: 260 -SSFGELKRLQMLKADRNSL 278

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 56/203 (27%), Positives = 98/203 (48%)
 Frame = +1

Query: 202 LDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSN 381
           +D   + L  IP  +F+   L  L L  N I+E+D  + +L  L+ L + +N++ +LP+ 
Sbjct: 18  IDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAE 77

Query: 382 PGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGL 561
            G   L  L  L+++ N +  LP+ + +C  LTTLNL  N    +PETI   +++    L
Sbjct: 78  IG--NLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSL 135

Query: 562 RYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGP 741
               LT LP+++     L  L    N +  +P  ++  L  +  + L +N   + P    
Sbjct: 136 NETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIV-ELRKLEELDLGQNELEALP-AEI 193

Query: 742 QQFASTQTLNLDHNQITQIPFGI 810
            +  S +   +D N +T +P  I
Sbjct: 194 GKLTSLREFYVDINSLTSLPDSI 216

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 34/97 (35%), Positives = 55/97 (56%)
 Frame = +1

Query: 13  ITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRL 192
           +T LP  I DL   L  L +  N L ++P+ +GN  +L +L L++N +T LP ++ +C  
Sbjct: 301 LTDLPDTIGDL-RQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTIGKCEN 359

Query: 193 LRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREV 303
           L +LD+  NKL  +P  V  L+ L  L L  N+ + +
Sbjct: 360 LTVLDVASNKLPHLPFTVKVLYKLQALWLSENQTQSI 396

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 38/135 (28%), Positives = 68/135 (50%)
 Frame = +1

Query: 406 LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
           + ++D S ++L+ +P  I    KL  LNL  N +K +   + +L  L    +  N L  L
Sbjct: 15  VDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVL 74

Query: 586 PASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGPQQFASTQT 765
           PA +     L ELN   N+I++LP+ +    + ++++ LS N F+  P     + +S   
Sbjct: 75  PAEIGNLTQLIELNLNRNSIAKLPDTMQNCKL-LTTLNLSSNPFTRLP-ETICECSSITI 132

Query: 766 LNLDHNQITQIPFGI 810
           L+L+   +T +P  I
Sbjct: 133 LSLNETSLTLLPSNI 147
>sp|Q7KRY7|LAP4_DROME LAP4 protein (Scribble protein) (Smell-impaired protein)
          Length = 1851

 Score =  128 bits (321), Expect = 2e-29
 Identities = 87/274 (31%), Positives = 143/274 (52%), Gaps = 2/274 (0%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + I  LPS    L  NL  L L    L  LP + G+L  LE L L+EN +  LP+++S
Sbjct: 114 SSNPIPKLPSGFSQLK-NLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETIS 172

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           Q   L+ LD+  N++ ++PP++  L  L  L L  N+++ +  E+  L KL  L + EN+
Sbjct: 173 QLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENR 232

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           +  LP+   +  LV+L  LD++ N LE LP+ I   ++LT L L  N L+ + +T+GN  
Sbjct: 233 LEELPNE--ISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCE 290

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
            ++   L  N L+ LPAS+     L  LN + N +  LP   +    ++  ++L  N   
Sbjct: 291 NMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLE-IGQCANLGVLSLRDNKLK 349

Query: 721 SFPLGGPQQFAST--QTLNLDHNQITQIPFGILS 816
             P   P+    T    L++  NQ+  +P+ +++
Sbjct: 350 KLP---PELGNCTVLHVLDVSGNQLLYLPYSLVN 380

 Score =  114 bits (286), Expect = 3e-25
 Identities = 81/290 (27%), Positives = 135/290 (46%), Gaps = 22/290 (7%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           + I  LP N   L H L++L L  N++  LP ++ N  NL  L +  N +  +PD +   
Sbjct: 47  NHIRDLPKNFFRL-HRLRKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHL 105

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L++ D   N + ++P    +L NLT L L    +  +  +  +L +L++L LREN ++
Sbjct: 106 QSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLK 165

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP    + +L  L+ LD+  N +E LP  +G+   L  L L HN+L+ +P  +G LT L
Sbjct: 166 HLPET--ISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKL 223

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-------------------- 666
               +  N L  LP  +S    L +L+   N +  LP+G+                    
Sbjct: 224 TYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLN 283

Query: 667 --LTHLIHVSSITLSRNYFSSFPLGGPQQFASTQTLNLDHNQITQIPFGI 810
             L +  ++  + L+ N+ S  P     Q      LN+D N +  +P  I
Sbjct: 284 DTLGNCENMQELILTENFLSELP-ASIGQMTKLNNLNVDRNALEYLPLEI 332

 Score =  106 bits (264), Expect = 9e-23
 Identities = 73/262 (27%), Positives = 126/262 (48%)
 Frame = +1

Query: 13  ITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRL 192
           +  +P  I   +  L+EL+L +N + +LP     L  L  L L +N +  LP  +     
Sbjct: 25  LPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFEN 84

Query: 193 LRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLL 372
           L  LD+  N + +IP  +  L +L       N I ++    + L+ L  L L +  +  L
Sbjct: 85  LVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTL 144

Query: 373 PSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALER 552
           P++ G   L  L++L++  N L+ LPE I   TKL  L+L  NE++ +P  +G L  L  
Sbjct: 145 PADFG--SLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHE 202

Query: 553 FGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPL 732
             L +N L  LP  L     L  L+   N + +LP   ++ L+ ++ + L++N   + P 
Sbjct: 203 LWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNE-ISGLVSLTDLDLAQNLLEALP- 260

Query: 733 GGPQQFASTQTLNLDHNQITQI 798
            G  + +    L LD N++ ++
Sbjct: 261 DGIAKLSRLTILKLDQNRLQRL 282

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 58/177 (32%), Positives = 92/177 (51%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q+  LP  +  L   L  L +  N+L  LPNE+  LV+L  L L +N + ALPD +++ 
Sbjct: 208 NQLQRLPPEL-GLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKL 266

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
             L IL +  N+L  +   +    N+  L+L  N + E+   I  + KL NL +  N + 
Sbjct: 267 SRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALE 326

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNL 537
            LP   G  +  NL  L +  N L+ LP  +G+CT L  L++  N+L  +P ++ NL
Sbjct: 327 YLPLEIG--QCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL 381

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 38/123 (30%), Positives = 61/123 (49%), Gaps = 1/123 (0%)
 Frame = +1

Query: 52  NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
           N++EL L  N L  LP  +G +  L  L +  N +  LP  + QC  L +L +R NKL +
Sbjct: 291 NMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKK 350

Query: 232 IPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR-LLPSNPGLEKLVNL 408
           +PP +     L  L +  N++  +   + NL+ L+ + L EN+ + LL   P  +     
Sbjct: 351 LPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQ-LKAVWLSENQSQPLLTFQPDTDAETGE 409

Query: 409 QTL 417
           Q L
Sbjct: 410 QVL 412
>sp|Q96NW7|LRRC7_HUMAN Leucine-rich repeat-containing protein 7 (LAP1 protein)
           (Densin-180)
          Length = 1537

 Score =  125 bits (313), Expect = 2e-28
 Identities = 87/269 (32%), Positives = 138/269 (51%), Gaps = 1/269 (0%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + I+ LP     L  NL +LYL    L  LP   G LV L IL L+EN +  LP S+ 
Sbjct: 123 SVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH 181

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           +   L  LD+ +N+  E+P  + ++ NL  L +  N ++ +   I  L+ L  L + +N+
Sbjct: 182 KLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNR 241

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           I  +  +  +     L+ L +S N L+ LP++IG   KLTTL +  N+L  +P TIGNL+
Sbjct: 242 IETVDMD--ISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-LTHLIHVSSITLSRNYF 717
            LE F    N L SLP+++ +   L  L  + N + +LP  +     + V S+  ++  F
Sbjct: 300 LLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEF 359

Query: 718 SSFPLGGPQQFASTQTLNLDHNQITQIPF 804
               +G   Q    + LNL  N++  +PF
Sbjct: 360 LPEEIG---QMQKLRVLNLSDNRLKNLPF 385

 Score =  109 bits (273), Expect = 9e-24
 Identities = 78/267 (29%), Positives = 126/267 (47%), Gaps = 2/267 (0%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +QI  LP  + +    L++L +  N L NLP  + +LVNL+ L + +N V   P+++  C
Sbjct: 56  NQIEELPKQLFN-CQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCC 114

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L I++   N + ++P    +L NLT L L    +  +      L KL+ L LREN ++
Sbjct: 115 KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLK 174

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP +  + KL  L+ LD+ +N    LPE +     L  L + +N L+ +P +IG L  L
Sbjct: 175 TLPKS--MHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKML 232

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE--GLLTHLIHVSSITLSRNYFS 720
               +  N + ++   +S C  L +L    N + QLP+  GLL  L              
Sbjct: 233 VYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL-------------- 278

Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIP 801
                         TL +D NQ+T +P
Sbjct: 279 -------------TTLKVDDNQLTMLP 292

 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 65/207 (31%), Positives = 101/207 (48%)
 Frame = +1

Query: 34  IKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIR 213
           + D   NL+EL++ +N L  LP  +G L  L  L + +N +  +   +S C  L  L + 
Sbjct: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLS 261

Query: 214 HNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIRLLPSNPGLE 393
            N L ++P  +  L  LT L +  N++  +   I NL  L+      N++  LPS  G  
Sbjct: 262 SNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGY- 320

Query: 394 KLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNH 573
            L +L+TL +  N L  LP  IG C  +T ++L+ N+L+ +PE IG +  L    L  N 
Sbjct: 321 -LHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNR 379

Query: 574 LTSLPASLSFCRMLCELNTEGNNISQL 654
           L +LP S +  + L  L    N    L
Sbjct: 380 LKNLPFSFTKLKELAALWLSDNQSKAL 406

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 37/122 (30%), Positives = 68/122 (55%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +Q+T LP+ I +L+  L+E     N+L +LP+ +G L +L  L + EN +  LP  +  C
Sbjct: 286 NQLTMLPNTIGNLSL-LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELpreIGSC 344

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + + ++ +R NKL  +P  + ++  L  L L  NR++ +      L++L  L L +N+ +
Sbjct: 345 KNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSK 404

Query: 367 LL 372
            L
Sbjct: 405 AL 406

 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 34/132 (25%), Positives = 66/132 (50%)
 Frame = +1

Query: 406 LQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTALERFGLRYNHLTSL 585
           L+ L +  N +E LP+ + +C  L  L++  N+L ++P TI +L  L+   +  N +   
Sbjct: 48  LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEF 107

Query: 586 PASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSFPLGGPQQFASTQT 765
           P ++  C+ L  +    N IS+LP+G  T L++++ + L+  +    P     +    + 
Sbjct: 108 PENIKCCKCLTIIEASVNPISKLPDG-FTQLLNLTQLYLNDAFLEFLP-ANFGRLVKLRI 165

Query: 766 LNLDHNQITQIP 801
           L L  N +  +P
Sbjct: 166 LELRENHLKTLP 177

 Score = 37.0 bits (84), Expect = 0.070
 Identities = 22/69 (31%), Positives = 36/69 (52%)
 Frame = +1

Query: 52  NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
           N+  + L SNKL  LP E+G +  L +L L +N +  LP S ++ + L  L +  N+   
Sbjct: 346 NVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 405

Query: 232 IPPFVFKLH 258
           + P   + H
Sbjct: 406 LIPLQTEAH 414
>sp|P70587|LRRC7_RAT Leucine-rich repeat-containing protein 7 (LAP1 protein)
           (Densin-180)
          Length = 1495

 Score =  124 bits (312), Expect = 3e-28
 Identities = 87/269 (32%), Positives = 137/269 (50%), Gaps = 1/269 (0%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + I+ LP     L  NL +LYL    L  LP   G LV L IL L+EN +  LP S+ 
Sbjct: 128 SVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH 186

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           +   L  LD+ +N+  E+P  + ++ NL  L +  N ++ +   I  L+ L  L + +N+
Sbjct: 187 KLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNR 246

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           I  +  +  +     L+ L +S N L+ LP++IG   KLTTL +  N+L  +P TIGNL+
Sbjct: 247 IETVDMD--ISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 304

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-LTHLIHVSSITLSRNYF 717
            LE F    N L SLP ++ +   L  L  + N + +LP  +     + V S+  ++  F
Sbjct: 305 LLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEF 364

Query: 718 SSFPLGGPQQFASTQTLNLDHNQITQIPF 804
               +G   Q    + LNL  N++  +PF
Sbjct: 365 LPEEIG---QMQRLRVLNLSDNRLKNLPF 390

 Score =  108 bits (271), Expect = 1e-23
 Identities = 77/267 (28%), Positives = 126/267 (47%), Gaps = 2/267 (0%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +QI  LP  + +    L++L +  N L +LP  + +LVNL+ L + +N V   P+++  C
Sbjct: 61  NQIEELPKQLFN-CQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCC 119

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L I++   N + ++P    +L NLT L L    +  +      L KL+ L LREN ++
Sbjct: 120 KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLK 179

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP +  + KL  L+ LD+ +N    LPE +     L  L + +N L+ +P +IG L  L
Sbjct: 180 TLPKS--MHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKML 237

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE--GLLTHLIHVSSITLSRNYFS 720
               +  N + ++   +S C  L +L    N + QLP+  GLL  L              
Sbjct: 238 VYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL-------------- 283

Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIP 801
                         TL +D NQ+T +P
Sbjct: 284 -------------TTLKVDDNQLTMLP 297

 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 66/216 (30%), Positives = 106/216 (49%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           ++ + LP  + D   NL+EL++ +N L  LP  +G L  L  L + +N +  +   +S C
Sbjct: 199 NEFSELPE-VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGC 257

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
             L  L +  N L ++P  +  L  LT L +  N++  +   I NL  L+      N++ 
Sbjct: 258 EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 317

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP  P +  L +L+TL +  N L  LP  IG C  +T ++L+ N+L+ +PE IG +  L
Sbjct: 318 SLP--PTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEFLPEEIGQMQRL 375

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQL 654
               L  N L +LP S +  + L  L    N    L
Sbjct: 376 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 411

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 54/172 (31%), Positives = 94/172 (54%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           SK++I ++  +I      L++L L SN L  LP+ +G L  L  L + +N +T LP+++ 
Sbjct: 243 SKNRIETVDMDISG-CEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
              LL   D   N+L  +PP +  LH+L  L +  N + E+ +EI + + +  ++LR NK
Sbjct: 302 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNK 361

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSI 516
           +  LP   G  ++  L+ L++S N L+ LP +     +L  L L  N+ K++
Sbjct: 362 LEFLPEEIG--QMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 411

 Score = 37.0 bits (84), Expect = 0.070
 Identities = 22/69 (31%), Positives = 36/69 (52%)
 Frame = +1

Query: 52  NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
           N+  + L SNKL  LP E+G +  L +L L +N +  LP S ++ + L  L +  N+   
Sbjct: 351 NVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 410

Query: 232 IPPFVFKLH 258
           + P   + H
Sbjct: 411 LIPLQTEAH 419
>sp|Q80TE7|LRRC7_MOUSE Leucine-rich repeat-containing protein 7 (LAP1 protein)
           (Densin-180)
          Length = 1490

 Score =  124 bits (312), Expect = 3e-28
 Identities = 87/269 (32%), Positives = 137/269 (50%), Gaps = 1/269 (0%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + I+ LP     L  NL +LYL    L  LP   G LV L IL L+EN +  LP S+ 
Sbjct: 123 SVNPISKLPDGFTQLL-NLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH 181

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           +   L  LD+ +N+  E+P  + ++ NL  L +  N ++ +   I  L+ L  L + +N+
Sbjct: 182 KLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNR 241

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           I  +  +  +     L+ L +S N L+ LP++IG   KLTTL +  N+L  +P TIGNL+
Sbjct: 242 IETVDMD--ISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGL-LTHLIHVSSITLSRNYF 717
            LE F    N L SLP ++ +   L  L  + N + +LP  +     + V S+  ++  F
Sbjct: 300 LLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEF 359

Query: 718 SSFPLGGPQQFASTQTLNLDHNQITQIPF 804
               +G   Q    + LNL  N++  +PF
Sbjct: 360 LPEEIG---QMQRLRVLNLSDNRLKNLPF 385

 Score =  108 bits (271), Expect = 1e-23
 Identities = 77/267 (28%), Positives = 126/267 (47%), Gaps = 2/267 (0%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +QI  LP  + +    L++L +  N L +LP  + +LVNL+ L + +N V   P+++  C
Sbjct: 56  NQIEELPKQLFN-CQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCC 114

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           + L I++   N + ++P    +L NLT L L    +  +      L KL+ L LREN ++
Sbjct: 115 KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLK 174

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP +  + KL  L+ LD+ +N    LPE +     L  L + +N L+ +P +IG L  L
Sbjct: 175 TLPKS--MHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKML 232

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPE--GLLTHLIHVSSITLSRNYFS 720
               +  N + ++   +S C  L +L    N + QLP+  GLL  L              
Sbjct: 233 VYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKL-------------- 278

Query: 721 SFPLGGPQQFASTQTLNLDHNQITQIP 801
                         TL +D NQ+T +P
Sbjct: 279 -------------TTLKVDDNQLTMLP 292

 Score = 97.4 bits (241), Expect = 4e-20
 Identities = 66/216 (30%), Positives = 106/216 (49%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           ++ + LP  + D   NL+EL++ +N L  LP  +G L  L  L + +N +  +   +S C
Sbjct: 194 NEFSELPE-VLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGC 252

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
             L  L +  N L ++P  +  L  LT L +  N++  +   I NL  L+      N++ 
Sbjct: 253 EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 312

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LP  P +  L +L+TL +  N L  LP  IG C  +T ++L+ N+L+ +PE IG +  L
Sbjct: 313 SLP--PTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNKLEFLPEEIGQMQRL 370

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQL 654
               L  N L +LP S +  + L  L    N    L
Sbjct: 371 RVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 54/172 (31%), Positives = 94/172 (54%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           SK++I ++  +I      L++L L SN L  LP+ +G L  L  L + +N +T LP+++ 
Sbjct: 238 SKNRIETVDMDISG-CEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 296

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
              LL   D   N+L  +PP +  LH+L  L +  N + E+ +EI + + +  ++LR NK
Sbjct: 297 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELpreIGSCKNVTVMSLRSNK 356

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSI 516
           +  LP   G  ++  L+ L++S N L+ LP +     +L  L L  N+ K++
Sbjct: 357 LEFLPEEIG--QMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406

 Score = 37.0 bits (84), Expect = 0.070
 Identities = 22/69 (31%), Positives = 36/69 (52%)
 Frame = +1

Query: 52  NLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQCRLLRILDIRHNKLCE 231
           N+  + L SNKL  LP E+G +  L +L L +N +  LP S ++ + L  L +  N+   
Sbjct: 346 NVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKA 405

Query: 232 IPPFVFKLH 258
           + P   + H
Sbjct: 406 LIPLQTEAH 414
>sp|Q96RT1|LAP2_HUMAN LAP2 protein (Erbb2-interacting protein) (Erbin) (Densin-180-like
           protein)
          Length = 1412

 Score =  123 bits (309), Expect = 6e-28
 Identities = 84/272 (30%), Positives = 133/272 (48%), Gaps = 2/272 (0%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S   +  +P  I      L+ELYL +N++  LP +L N  +L  L L +N +T LP S++
Sbjct: 30  SHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIA 89

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
               LR LD+  N + E P  +     LT +    N I ++    + L  L  L L +  
Sbjct: 90  NLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAF 149

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           +  LP+N G  +L  LQ L++  N L+MLP+ +   T+L  L+L  NE   +PE +  L+
Sbjct: 150 LEFLPANFG--RLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLS 207

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
            L+ F +  N LT +P  +   + L  L+   NNI  + EG+ T   ++  + LS N   
Sbjct: 208 GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIST-CENLQDLLLSSNSLQ 266

Query: 721 SFP--LGGPQQFASTQTLNLDHNQITQIPFGI 810
             P  +G      +  TL +D NQ+  +P  I
Sbjct: 267 QLPETIG---SLKNITTLKIDENQLMYLPDSI 295

 Score =  120 bits (301), Expect = 5e-27
 Identities = 81/270 (30%), Positives = 138/270 (51%), Gaps = 2/270 (0%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + I+ LP     L  NL +LYL    L  LP   G L  L+IL L+EN +  LP +++
Sbjct: 123 SVNPISKLPDGFSQLL-NLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMN 181

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           +   L  LD+  N+  E+P  + +L  L    +  NR+  +   I +L++L  L + +N 
Sbjct: 182 RLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNN 241

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLT 540
           I ++    G+    NLQ L +S N L+ LPE IG    +TTL +  N+L  +P++IG L 
Sbjct: 242 IEMVEE--GISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLI 299

Query: 541 ALERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFS 720
           ++E     +N + +LP+S+     L     + N + QLP  + +   +++ + L  N   
Sbjct: 300 SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK-NITVLFLHSNKLE 358

Query: 721 SFP--LGGPQQFASTQTLNLDHNQITQIPF 804
           + P  +G  Q+    + +NL  N++  +PF
Sbjct: 359 TLPEEMGDMQKL---KVINLSDNRLKNLPF 385

 Score =  114 bits (286), Expect = 3e-25
 Identities = 76/270 (28%), Positives = 133/270 (49%), Gaps = 2/270 (0%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           +QI  LP  + +   +L +L L  N L  LP  + NL+NL  L + +N +   P+++  C
Sbjct: 56  NQIEELPKQLFN-CQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNC 114

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
           ++L I++   N + ++P    +L NLT L L    +  +      L KLQ L LREN+++
Sbjct: 115 KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLK 174

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
           +LP    + +L  L+ LD+  N    +PE +   + L    +  N L  IP  IG+L  L
Sbjct: 175 MLPKT--MNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQL 232

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQLPEGLLTHLIHVSSITLSRNYFSSF 726
               +  N++  +   +S C  L +L    N++ QLPE  +  L +++++ +  N     
Sbjct: 233 TYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPE-TIGSLKNITTLKIDENQLMYL 291

Query: 727 P--LGGPQQFASTQTLNLDHNQITQIPFGI 810
           P  +GG     S + L+   N++  +P  I
Sbjct: 292 PDSIGG---LISVEELDCSFNEVEALPSSI 318

 Score =  103 bits (257), Expect = 6e-22
 Identities = 63/216 (29%), Positives = 114/216 (52%)
 Frame = +1

Query: 7   SQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLSQC 186
           ++ T +P  ++ L+  LKE ++ +N+L  +P  +G+L  L  L + +N +  + + +S C
Sbjct: 194 NEFTEVPEVLEQLS-GLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTC 252

Query: 187 RLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENKIR 366
             L+ L +  N L ++P  +  L N+T L +  N++  +   I  L  ++ L    N++ 
Sbjct: 253 ENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVE 312

Query: 367 LLPSNPGLEKLVNLQTLDISHNHLEMLPEAIGHCTKLTTLNLQHNELKSIPETIGNLTAL 546
            LPS+ G  +L NL+T    HN+L+ LP  IG    +T L L  N+L+++PE +G++  L
Sbjct: 313 ALPSSIG--QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370

Query: 547 ERFGLRYNHLTSLPASLSFCRMLCELNTEGNNISQL 654
           +   L  N L +LP S +  + L  +    N    L
Sbjct: 371 KVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPL 406

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 47/149 (31%), Positives = 81/149 (54%)
 Frame = +1

Query: 1   SKSQITSLPSNIKDLAHNLKELYLYSNKLINLPNELGNLVNLEILMLQENCVTALPDSLS 180
           S + +  LP  I  L  N+  L +  N+L+ LP+ +G L+++E L    N V ALP S+ 
Sbjct: 261 SSNSLQQLPETIGSLK-NITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIG 319

Query: 181 QCRLLRILDIRHNKLCEIPPFVFKLHNLTHLLLRFNRIREVDQEIANLEKLQNLTLRENK 360
           Q   LR     HN L ++PP +    N+T L L  N++  + +E+ +++KL+ + L +N+
Sbjct: 320 QLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNR 379

Query: 361 IRLLPSNPGLEKLVNLQTLDISHNHLEML 447
           ++ LP +    KL  L  + +S N  + L
Sbjct: 380 LKNLPFS--FTKLQQLTAMWLSDNQSKPL 406
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,272,706
Number of Sequences: 369166
Number of extensions: 2256705
Number of successful extensions: 9293
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6708
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7898
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)