Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02774
(759 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P30531|SC6A1_HUMAN Sodium- and chloride-dependent GABA t... 299 6e-81
sp|P23978|SC6A1_RAT Sodium- and chloride-dependent GABA tra... 298 8e-81
sp|P48057|SC6A1_MUSCO Sodium- and chloride-dependent GABA t... 295 7e-80
sp|O18875|SC6A8_BOVIN Sodium- and chloride-dependent creati... 252 7e-67
sp|P28570|SC6A8_RAT Sodium- and chloride-dependent creatine... 251 1e-66
sp|P48029|SC6A8_HUMAN Sodium- and chloride-dependent creati... 251 1e-66
sp|P31661|SC6A8_RABIT Sodium- and chloride-dependent creati... 249 4e-66
sp|Q91502|SC6A8_TORMA Creatine transporter 248 2e-65
sp|P48066|S6A11_HUMAN Sodium- and chloride-dependent GABA t... 247 3e-65
sp|P31647|S6A11_RAT Sodium- and chloride-dependent GABA tra... 246 5e-65
>sp|P30531|SC6A1_HUMAN Sodium- and chloride-dependent GABA transporter 1
Length = 599
Score = 299 bits (765), Expect = 6e-81
Identities = 135/250 (54%), Positives = 181/250 (72%)
Frame = +3
Query: 9 EEGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVG 188
+EGI+FY+ P+ KL +S+VWLD ATQIFFSYGLGLG+ IALGSYN ++NN +RD++IV
Sbjct: 265 KEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVC 324
Query: 189 VVNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXX 368
+N+ TS+FAGFV+FS++GFMAH SG GL FL YP A+ QLP S +W+
Sbjct: 325 CINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAIL 384
Query: 369 XXXXXXXXXXDSQFCTLEGFVTAIIDEWPNKFRNHRKLLLFVVCVVSYLIGILMVTQGGA 548
DSQFCT+EGF+TA++DE+P RN R+L + VC++SYLIG+ +TQGG
Sbjct: 385 FFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIISYLIGLSNITQGGI 444
Query: 549 YVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLICC 728
YVF+LFD+YSASGM+LLFL+F EC++ SW YG+NRF + ++M+G + WWK CW
Sbjct: 445 YVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFT 504
Query: 729 PLVCMFVFIF 758
P++ VFIF
Sbjct: 505 PIIVAGVFIF 514
>sp|P23978|SC6A1_RAT Sodium- and chloride-dependent GABA transporter 1
sp|P31648|SC6A1_MOUSE Sodium- and chloride-dependent GABA transporter 1
Length = 599
Score = 298 bits (764), Expect = 8e-81
Identities = 135/250 (54%), Positives = 181/250 (72%)
Frame = +3
Query: 9 EEGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVG 188
+EGI+FY+ P+ KL +S+VWLD ATQIFFSYGLGLG+ IALGSYN ++NN +RD++IV
Sbjct: 265 KEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVC 324
Query: 189 VVNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXX 368
+N+ TS+FAGFV+FS++GFMAH SG GL FL YP A+ QLP S +W+
Sbjct: 325 CINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAIL 384
Query: 369 XXXXXXXXXXDSQFCTLEGFVTAIIDEWPNKFRNHRKLLLFVVCVVSYLIGILMVTQGGA 548
DSQFCT+EGF+TA++DE+P RN R+L + VC+VSYLIG+ +TQGG
Sbjct: 385 FFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGI 444
Query: 549 YVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLICC 728
YVF+LFD+YSASGM+LLFL+F EC++ SW YG+NRF + ++M+G + WWK CW
Sbjct: 445 YVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFT 504
Query: 729 PLVCMFVFIF 758
P++ VF+F
Sbjct: 505 PIIVAGVFLF 514
>sp|P48057|SC6A1_MUSCO Sodium- and chloride-dependent GABA transporter 1
Length = 598
Score = 295 bits (756), Expect = 7e-80
Identities = 134/250 (53%), Positives = 180/250 (72%)
Frame = +3
Query: 9 EEGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVG 188
+EGI+FY+ P+ KL +S+VWLD ATQIFFSYGLGLG+ IALGSYN ++NN +RD++IV
Sbjct: 264 KEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVC 323
Query: 189 VVNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXX 368
+N+ TS+FAGFV+FS++GFMAH SG GL FL YP A+ QLP S +W+
Sbjct: 324 CINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAIL 383
Query: 369 XXXXXXXXXXDSQFCTLEGFVTAIIDEWPNKFRNHRKLLLFVVCVVSYLIGILMVTQGGA 548
DSQFCT+EGF+TA++DE+ RN R+L + VC+VSYLIG+ +TQGG
Sbjct: 384 FFSMLLMLGIDSQFCTVEGFITALVDEYSRLLRNRRELFIAAVCIVSYLIGLSNITQGGI 443
Query: 549 YVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLICC 728
YVF+LFD+YSASGM+LLFL+F EC++ SW YG+NRF + ++M+G + WWK CW
Sbjct: 444 YVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFT 503
Query: 729 PLVCMFVFIF 758
P++ VF+F
Sbjct: 504 PIIVAGVFLF 513
>sp|O18875|SC6A8_BOVIN Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine
transporter 1) (Solute carrier family 6 member 8)
Length = 635
Score = 252 bits (644), Expect = 7e-67
Identities = 118/251 (47%), Positives = 164/251 (65%), Gaps = 2/251 (0%)
Frame = +3
Query: 12 EGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVGV 191
+GI++YLKPD SKL +VW+D TQIFFSY +GLG ALGSYN++NNNC++DA+I+ +
Sbjct: 287 DGIIYYLKPDWSKLASPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILAL 346
Query: 192 VNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXXX 371
+N+ TS FAGFVVFS++GFMA SG GL F+ YP A+ +P + +W+
Sbjct: 347 INSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALF 406
Query: 372 XXXXXXXXXDSQFCTLEGFVTAIIDEWPNK--FRNHRKLLLFVVCVVSYLIGILMVTQGG 545
DSQF +EGF+T ++D P FR R++ + + C + ++I + MVT GG
Sbjct: 407 FFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCTICFVIDLSMVTDGG 466
Query: 546 AYVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLIC 725
YVF+LFD+YSASG LL+ F EC+ +W YG +RFM D M+G++ W K+CW
Sbjct: 467 MYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDVACMIGYRPCPWMKWCWSFF 526
Query: 726 CPLVCMFVFIF 758
PLVCM +FIF
Sbjct: 527 TPLVCMGIFIF 537
>sp|P28570|SC6A8_RAT Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine
transporter 1) (CHOT1) (Solute carrier family 6 member 8)
Length = 635
Score = 251 bits (641), Expect = 1e-66
Identities = 118/251 (47%), Positives = 164/251 (65%), Gaps = 2/251 (0%)
Frame = +3
Query: 12 EGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVGV 191
+GI++YLKPD SKL +VW+D TQIFFSY +GLG ALGSYN++NNNC++DA+I+ +
Sbjct: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILAL 346
Query: 192 VNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXXX 371
+N+ TS FAGFVVFS++GFMA SG GL F+ YP A+ +P + +W+
Sbjct: 347 INSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALF 406
Query: 372 XXXXXXXXXDSQFCTLEGFVTAIIDEWPNK--FRNHRKLLLFVVCVVSYLIGILMVTQGG 545
DSQF +EGF+T ++D P FR R++ + + C + ++I + MVT GG
Sbjct: 407 FFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGG 466
Query: 546 AYVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLIC 725
YVF+LFD+YSASG LL+ F EC+ +W YG +RFM D M+G++ W K+CW
Sbjct: 467 MYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFF 526
Query: 726 CPLVCMFVFIF 758
PLVCM +FIF
Sbjct: 527 TPLVCMGIFIF 537
>sp|P48029|SC6A8_HUMAN Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine
transporter 1) (Solute carrier family 6 member 8)
Length = 635
Score = 251 bits (641), Expect = 1e-66
Identities = 118/251 (47%), Positives = 164/251 (65%), Gaps = 2/251 (0%)
Frame = +3
Query: 12 EGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVGV 191
+GI++YLKPD SKL +VW+D TQIFFSY +GLG ALGSYN++NNNC++DA+I+ +
Sbjct: 287 DGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILAL 346
Query: 192 VNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXXX 371
+N+ TS FAGFVVFS++GFMA SG GL F+ YP A+ +P + +W+
Sbjct: 347 INSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALF 406
Query: 372 XXXXXXXXXDSQFCTLEGFVTAIIDEWPNK--FRNHRKLLLFVVCVVSYLIGILMVTQGG 545
DSQF +EGF+T ++D P FR R++ + + C + ++I + MVT GG
Sbjct: 407 FFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGG 466
Query: 546 AYVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLIC 725
YVF+LFD+YSASG LL+ F EC+ +W YG +RFM D M+G++ W K+CW
Sbjct: 467 MYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFF 526
Query: 726 CPLVCMFVFIF 758
PLVCM +FIF
Sbjct: 527 TPLVCMGIFIF 537
>sp|P31661|SC6A8_RABIT Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine
transporter 1) (Solute carrier family 6 member 8)
Length = 635
Score = 249 bits (637), Expect = 4e-66
Identities = 117/251 (46%), Positives = 164/251 (65%), Gaps = 2/251 (0%)
Frame = +3
Query: 12 EGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVGV 191
+GI++YLKPD SKL+ +VW+D TQIFFSY +GLG ALGSYN++NNNC++DA+I+ +
Sbjct: 287 DGIIYYLKPDWSKLRSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILAL 346
Query: 192 VNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXXX 371
+N+ TS FAGFVVFS++GFMA SG GL F+ YP A+ +P + +W+
Sbjct: 347 INSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALF 406
Query: 372 XXXXXXXXXDSQFCTLEGFVTAIIDEWPNK--FRNHRKLLLFVVCVVSYLIGILMVTQGG 545
DSQF +EGF+T ++D P FR R++ + + C + ++I + MV G
Sbjct: 407 FFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVQMAG 466
Query: 546 AYVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLIC 725
YVF+LFD+YSASG LL+ F EC+A +W YG +RFM D M+G++ W K+CW
Sbjct: 467 MYVFQLFDYYSASGTTLLWQAFWECVAVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFF 526
Query: 726 CPLVCMFVFIF 758
PLVCM +FIF
Sbjct: 527 TPLVCMGIFIF 537
>sp|Q91502|SC6A8_TORMA Creatine transporter
Length = 611
Score = 248 bits (632), Expect = 2e-65
Identities = 118/251 (47%), Positives = 170/251 (67%), Gaps = 2/251 (0%)
Frame = +3
Query: 12 EGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVGV 191
+GI++YL+PD KL E++VW+D TQIFFSY +GLGT ALGSYN+ +N+C++DA I+ +
Sbjct: 264 QGIVYYLQPDWGKLGEAQVWIDAGTQIFFSYAIGLGTLTALGSYNQLHNDCYKDAFILSL 323
Query: 192 VNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXXX 371
VN++TS FAG VVFS++GFMA SG GL F+ YP A+ +P VW+
Sbjct: 324 VNSATSFFAGLVVFSILGFMAVEEGVDISVVAESGPGLAFIAYPKAVTLMPFPQVWAVLF 383
Query: 372 XXXXXXXXXDSQFCTLEGFVTAIIDEWPNK--FRNHRKLLLFVVCVVSYLIGILMVTQGG 545
SQF +EGFVTAI+D WP+K FR R++++ +V +S+LI + M+T+GG
Sbjct: 384 FIMLLCLGLGSQFVGVEGFVTAILDLWPSKFSFRYLREVVVAMVICLSFLIDLSMITEGG 443
Query: 546 AYVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLIC 725
Y+F++FD+YSASG LL+ F EC+A +W YG +R++ D MLG++ + K+CW +
Sbjct: 444 MYIFQIFDYYSASGTTLLWTAFWECVAVAWVYGGDRYLDDLAWMLGYRPWALVKWCWSVI 503
Query: 726 CPLVCMFVFIF 758
PLVCM +F F
Sbjct: 504 TPLVCMGIFTF 514
>sp|P48066|S6A11_HUMAN Sodium- and chloride-dependent GABA transporter 3
Length = 632
Score = 247 bits (630), Expect = 3e-65
Identities = 116/251 (46%), Positives = 161/251 (64%), Gaps = 2/251 (0%)
Frame = +3
Query: 12 EGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVGV 191
EGI FYL PD+S+L + +VW+D TQIFFSY + LG ALGSYN YNNNC+RD +++
Sbjct: 280 EGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCC 339
Query: 192 VNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXXX 371
+N+ TS AGF +FSV+GFMA+ SG GL F+ YP A+ +P S +W+
Sbjct: 340 LNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLF 399
Query: 372 XXXXXXXXXDSQFCTLEGFVTAIIDEWPNKFRN--HRKLLLFVVCVVSYLIGILMVTQGG 545
DSQF +E VTA++D +P FR R+LL+ + V+SY +G++M+T+GG
Sbjct: 400 FMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGG 459
Query: 546 AYVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLIC 725
Y+F+LFD Y+ASGM LLF+ ECI W YG NRF + E M+G++ K+CW+I
Sbjct: 460 MYIFQLFDSYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIM 519
Query: 726 CPLVCMFVFIF 758
P +C +FIF
Sbjct: 520 TPGICAGIFIF 530
>sp|P31647|S6A11_RAT Sodium- and chloride-dependent GABA transporter 3
Length = 627
Score = 246 bits (628), Expect = 5e-65
Identities = 114/251 (45%), Positives = 160/251 (63%), Gaps = 2/251 (0%)
Frame = +3
Query: 12 EGIMFYLKPDISKLKESKVWLDGATQIFFSYGLGLGTHIALGSYNKYNNNCHRDALIVGV 191
EGI FYL PD+S+L + +VW+D TQIFFSY + LG ALGSYN YNNNC+RD +++
Sbjct: 275 EGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCC 334
Query: 192 VNASTSLFAGFVVFSVMGFMAHXXXXXXXXXXXSGQGLIFLVYPSALAQLPGSAVWSXXX 371
+N+ TS AGF +FSV+GFMA+ SG GL F+ YP A+ +P S +W+
Sbjct: 335 LNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLF 394
Query: 372 XXXXXXXXXDSQFCTLEGFVTAIIDEWPNKFRN--HRKLLLFVVCVVSYLIGILMVTQGG 545
DSQF +E VTA++D +P FR R+LL+ + +VSY +G++M+T+GG
Sbjct: 395 FMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIVSYFLGLVMLTEGG 454
Query: 546 AYVFRLFDHYSASGMALLFLIFCECIAFSWCYGINRFMKDCEKMLGFKLFRWWKFCWLIC 725
Y+F+LFD Y+ASGM LLF+ EC+ W YG NRF + E M+G++ K+CW +
Sbjct: 455 MYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVV 514
Query: 726 CPLVCMFVFIF 758
P +C +FIF
Sbjct: 515 TPGICAGIFIF 525
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,541,728
Number of Sequences: 369166
Number of extensions: 1783429
Number of successful extensions: 4450
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4148
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4338
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6970118400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)