Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02722
(854 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydrat... 140 6e-33
sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydra... 136 8e-32
sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydra... 135 2e-31
sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehy... 133 5e-31
sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydra... 133 7e-31
sp|P00918|CAH2_HUMAN Carbonic anhydrase II (Carbonate dehyd... 127 5e-29
sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydra... 126 9e-29
sp|P27139|CAH2_RAT Carbonic anhydrase II (Carbonate dehydra... 121 2e-27
sp|P00921|CAH2_BOVIN Carbonic anhydrase 2 (Carbonic anhydra... 121 2e-27
sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydr... 121 2e-27
>sp|Q92051|CAHZ_BRARE Carbonic anhydrase (Carbonate dehydratase)
Length = 260
Score = 140 bits (352), Expect = 6e-33
Identities = 86/243 (35%), Positives = 127/243 (52%), Gaps = 4/243 (1%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSV-Y 177
GP W + NG RQSPIDI+PT LK + + ++ S++ + HS V +
Sbjct: 12 GPESWAE-SFPIANGPRQSPIDIVPTQAQHDPSLKHLKLKYDPATTKSILNNGHSFQVDF 70
Query: 178 ITFNRIWKISFGR-KGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
+ + ++ G G R H+HWGS+++ GSEH + GT FP E HLV+++ K Y +
Sbjct: 71 VDDDNSSTLAGGPITGIYRLRQFHFHWGSSDDKGSEHTIAGTKFPCELHLVHWNTK-YPN 129
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPKNL 534
F EA S P GL V+G F +IG N L KV++++ + + + P+ LP +L
Sbjct: 130 FGEAASKPDGLAVVGVFLKIGAANPRLQKVLDALDDIKSKGR-QTTFANFDPKTLLPASL 188
Query: 535 VKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXFGYPEKGP--MVDNFRPT 708
Y+ YEGSLTTPP E+V W VL+ + F + P MVDN+RP
Sbjct: 189 -DYWTYEGSLTTPPLLESVTWIVLKEPISVSPAQMAKFRSLLFSSEGETPCCMVDNYRPP 247
Query: 709 MPM 717
P+
Sbjct: 248 QPL 250
>sp|P00919|CAH2_RABIT Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 259
Score = 136 bits (342), Expect = 8e-32
Identities = 88/244 (36%), Positives = 126/244 (51%), Gaps = 5/244 (2%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GP W K NG+RQSPIDI LKP+ V + S +I + HS +V
Sbjct: 11 GPEHWHK-DFPIANGERQSPIDIDTNAAKHDPSLKPLRVCYEHPISRRIINNGHSFNVEF 69
Query: 181 --TFNRIWKISFGRKGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
+ ++ +G R + H+HWGS++ GSEH +N + E HLV+++ K Y
Sbjct: 70 DDSHDKTVLKEGPLEGTYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTK-YGD 128
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPKNL 534
F +A P GL V+G F +IG L KV++++ S+ K S++ T+ PR LP++L
Sbjct: 129 FGKAVKHPDGLAVLGIFLKIGSATPGLQKVVDTLSSIKTKGK-SVDFTDFDPRGLLPESL 187
Query: 535 VKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXF---GYPEKGPMVDNFRP 705
Y+ Y GSLTTPP E V W VL+ + F PE+ PMVDN+RP
Sbjct: 188 -DYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMLKFRNLNFNKEAEPEE-PMVDNWRP 245
Query: 706 TMPM 717
T P+
Sbjct: 246 TQPL 249
>sp|Q9ERQ8|CAH7_MOUSE Carbonic anhydrase 7 (Carbonic anhydrase VII) (Carbonate
dehydratase VII) (CA-VII)
Length = 264
Score = 135 bits (339), Expect = 2e-31
Identities = 87/246 (35%), Positives = 129/246 (52%), Gaps = 7/246 (2%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GPS W KL G RQSPI+I+ + ++ L+P+ + S S+ + HS V
Sbjct: 14 GPSNWHKL-YPIAQGDRQSPINIISSQAVYSPSLQPLELFYEACMSLSITNNGHSVQVDF 72
Query: 181 TFNRIWKISFGR--KGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
+ + G +G R LH+HWG ++GSEH ++G +FP E HLV+++ K YS+
Sbjct: 73 NDSDDRTVVSGGPLEGPYRLKQLHFHWGKKRDMGSEHTVDGKSFPSELHLVHWNAKKYST 132
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSV---DNSSKFSLNITEIPpreFLP 525
F EA +AP GL V+G F G + ++N++ +++ V D ++FS P+ LP
Sbjct: 133 FGEAAAAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKDTKAQFSC----FNPKCLLP 188
Query: 526 KNLVKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXFGY--PEKGPMVDNF 699
+ Y+ Y GSLTTPP +E+V W VLR I F E+ MVDNF
Sbjct: 189 TSR-HYWTYPGSLTTPPLSESVTWIVLREPIRISERQMEKFRSLLFTSEDDERIHMVDNF 247
Query: 700 RPTMPM 717
RP P+
Sbjct: 248 RPPQPL 253
>sp|P43166|CAH7_HUMAN Carbonic anhydrase VII (Carbonate dehydratase VII) (CA-VII)
Length = 264
Score = 133 bits (335), Expect = 5e-31
Identities = 87/246 (35%), Positives = 129/246 (52%), Gaps = 7/246 (2%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GPS W KL G RQSPI+I+ + ++ L+P+ +S S S+ + HS V
Sbjct: 14 GPSHWHKL-YPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDF 72
Query: 181 TFNRIWKISFGR--KGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
+ + G +G R H+HWG ++VGSEH ++G +FP E HLV+++ K YS+
Sbjct: 73 NDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYST 132
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSV---DNSSKFSLNITEIPpreFLP 525
F EA SAP GL V+G F G + ++N++ +++ V ++FS P+ LP
Sbjct: 133 FGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC----FNPKCLLP 188
Query: 526 KNLVKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXFGY--PEKGPMVDNF 699
+ Y+ Y GSLTTPP +E+V W VLR I F E+ MV+NF
Sbjct: 189 ASR-HYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNF 247
Query: 700 RPTMPM 717
RP P+
Sbjct: 248 RPPQPL 253
>sp|Q8UWA5|CAH2_TRIHK Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 133 bits (334), Expect = 7e-31
Identities = 84/243 (34%), Positives = 129/243 (53%), Gaps = 4/243 (1%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSV-Y 177
GP +W + NG RQSPIDI + LKP+ + T+S ++ + HS V +
Sbjct: 12 GPQKWCE-NFPIANGPRQSPIDIQTKGASYDDTLKPLKLKYDPTTSLDILNNGHSFQVTF 70
Query: 178 ITFNRIWKISFGR-KGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
N ++ G G R H+HWG+++ GSEH ++G +P E HLV+++ K Y+S
Sbjct: 71 ADDNDSSMLTEGPISGKYRLKQFHFHWGASDGKGSEHTVDGKCYPAELHLVHWNTK-YAS 129
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPKNL 534
F EA + P GL V+G F +IG+ N L K++++M ++ + K + T P LPK+L
Sbjct: 130 FGEAANKPDGLAVVGVFLQIGEDNPKLQKILDAMDAIKSKGK-QTSFTNFDPTCLLPKSL 188
Query: 535 VKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXFGYPEKGP--MVDNFRPT 708
+Y+ Y GSLTTPP E+V W V + + F E+ MV+N+RP
Sbjct: 189 -EYWTYPGSLTTPPLYESVTWIVCKQPISVSSEQMKKFRSLLFTAEEEKACCMVNNYRPP 247
Query: 709 MPM 717
P+
Sbjct: 248 QPL 250
>sp|P00918|CAH2_HUMAN Carbonic anhydrase II (Carbonate dehydratase II) (CA-II) (Carbonic
anhydrase C)
Length = 260
Score = 127 bits (318), Expect = 5e-29
Identities = 83/244 (34%), Positives = 123/244 (50%), Gaps = 5/244 (2%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GP W K G+RQSP+DI + LKP++VS +S ++ + H+ +V
Sbjct: 12 GPEHWHK-DFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEF 70
Query: 181 TFNRIWKISFGRK--GCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
++ + G G R + H+HWGS + GSEH ++ + E HLV+++ K Y
Sbjct: 71 DDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTK-YGD 129
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPKNL 534
F +A P GL V+G F ++G L KV++ + S+ K S + T PR LP++L
Sbjct: 130 FGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGK-SADFTNFDPRGLLPESL 188
Query: 535 VKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXF---GYPEKGPMVDNFRP 705
Y+ Y GSLTTPP E V W VL+ + F G PE+ MVDN+RP
Sbjct: 189 -DYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEE-LMVDNWRP 246
Query: 706 TMPM 717
P+
Sbjct: 247 AQPL 250
>sp|P00920|CAH2_MOUSE Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 126 bits (316), Expect = 9e-29
Identities = 84/245 (34%), Positives = 121/245 (49%), Gaps = 6/245 (2%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GP W K NG RQSP+DI L+P+ +S +S S++ + HS +V
Sbjct: 12 GPENWHK-DFPIANGDRQSPVDIDTATAHHDPALQPLLISYDKAASKSIVNNGHSFNVEF 70
Query: 181 TFNRIWKISFGR--KGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
++ + G R + H+HWGS++ GSEH +N + E HLV+++ K Y
Sbjct: 71 DDSQDNAVLKGGPLSDSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTK-YGD 129
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPKNL 534
F +A P GL V+G+F +IG + L KV+E++ S+ K + P LP NL
Sbjct: 130 FGKAVQQPDGLAVLGYFLKIGPASQGLQKVLEALHSIKTKGKRAA-FANFDPCSLLPGNL 188
Query: 535 VKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXFGYPEKG----PMVDNFR 702
Y+ Y GSLTTPP E V W VLR + I + E+G MVDN+R
Sbjct: 189 -DYWTYPGSLTTPPLLECVTWIVLR--EPITVSSEQMSHFRTLNFNEEGDAEEAMVDNWR 245
Query: 703 PTMPM 717
P P+
Sbjct: 246 PAQPL 250
>sp|P27139|CAH2_RAT Carbonic anhydrase II (Carbonate dehydratase II) (CA-II)
Length = 260
Score = 121 bits (304), Expect = 2e-27
Identities = 79/243 (32%), Positives = 117/243 (48%), Gaps = 4/243 (1%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GP W K + NG RQSP+DI L+P+ + +S S++ + HS +V
Sbjct: 12 GPENWHK-EFPIANGDRQSPVDIDTGTAQHDPSLQPLLICYDKVASKSIVNNGHSFNVEF 70
Query: 181 TFNRIWKI--SFGRKGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
++ + + G R + H+HWGS++ GSEH +N + E HLV+++ K Y
Sbjct: 71 DDSQDFAVLKEGPLSGSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTK-YGD 129
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPKNL 534
F +A P GL V+G F +IG + L K+ E++ S+ K + P LP NL
Sbjct: 130 FGKAVQHPDGLAVLGIFLKIGPASQGLQKITEALHSIKTKGKRAA-FANFDPCSLLPGNL 188
Query: 535 VKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXFGYPEKGP--MVDNFRPT 708
Y+ Y GSLTTPP E V W VL+ + F + MVDN+RP
Sbjct: 189 -DYWTYPGSLTTPPLLECVTWIVLKEPITVSSEQMSHFRKLNFNSEGEAEELMVDNWRPA 247
Query: 709 MPM 717
P+
Sbjct: 248 QPL 250
>sp|P00921|CAH2_BOVIN Carbonic anhydrase 2 (Carbonic anhydrase II) (Carbonate dehydratase
II) (CA-II)
Length = 260
Score = 121 bits (304), Expect = 2e-27
Identities = 81/244 (33%), Positives = 122/244 (50%), Gaps = 5/244 (2%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GP W K NG+RQSP+DI + LKP+ + +S ++ + HS +V
Sbjct: 12 GPEHWHK-DFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEY 70
Query: 181 TFNRIWKI--SFGRKGCLRPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLYSS 354
++ + G R V H+HWGS+++ GSEH ++ + E HLV+++ K Y
Sbjct: 71 DDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTK-YGD 129
Query: 355 FKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPKNL 534
F A P GL V+G F ++G N AL KV++++ S+ K S + P LP N+
Sbjct: 130 FGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGK-STDFPNFDPGSLLP-NV 187
Query: 535 VKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXF---GYPEKGPMVDNFRP 705
+ Y+ Y GSLTTPP E+V W VL+ + F G PE M+ N+RP
Sbjct: 188 LDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPEL-LMLANWRP 246
Query: 706 TMPM 717
P+
Sbjct: 247 AQPL 250
>sp|Q7M316|CAH1_GORGO Carbonic anhydrase I (Carbonate dehydratase I) (CA-I)
Length = 261
Score = 121 bits (304), Expect = 2e-27
Identities = 81/245 (33%), Positives = 117/245 (47%), Gaps = 6/245 (2%)
Frame = +1
Query: 1 GPSQWKKLKIATCNGQRQSPIDILPTYTIFWSDLKPINVSRINTSSDSVIIDKHSTSVYI 180
GP QW KL NG QSP+DI + T + LKPI+VS ++ +I HS ++
Sbjct: 13 GPEQWSKL-YPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHS--FHV 69
Query: 181 TFNRIWKISFGRKGCL----RPVALHWHWGSNNNVGSEHKLNGTAFPIEGHLVNYDCKLY 348
TF S + G L R H+HWGS N GSEH ++G + E HL +++ Y
Sbjct: 70 TFEDNDNRSVLKGGPLSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHLTHWNSAKY 129
Query: 349 SSFKEAQSAPSGLHVIGFFYRIGKHNTALNKVIESMKSVDNSSKFSLNITEIPpreFLPK 528
SS EA S GL VIG ++G+ N L K++++++++ K T P LP
Sbjct: 130 SSLAEAASKADGLAVIGVLMKVGEANPKLQKILDALQAIKTKGK-RAPFTNFDPSTLLPS 188
Query: 529 NLVKYYRYEGSLTTPPCTENVIWTVLRNVQDIXXXXXXXXXXXXFGYPEKG--PMVDNFR 702
+L ++ Y GSLT PP E+V W + + + PM N R
Sbjct: 189 SL-DFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNR 247
Query: 703 PTMPM 717
PT P+
Sbjct: 248 PTQPL 252
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,217,652
Number of Sequences: 369166
Number of extensions: 1911352
Number of successful extensions: 4233
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3909
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4075
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)