Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02708
(437 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54985|CYPH_BLAGE Peptidyl-prolyl cis-trans isomerase (P... 147 1e-35
sp|P91791|CYPH_HEMPU Peptidyl-prolyl cis-trans isomerase (P... 147 1e-35
sp|P14851|PPIA_CRIGR Peptidyl-prolyl cis-trans isomerase A ... 144 1e-34
sp|P10111|PPIA_RAT Peptidyl-prolyl cis-trans isomerase A (P... 144 1e-34
sp|P62937|PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A ... 144 1e-34
sp|Q9TTC6|PPIA_RABIT Peptidyl-prolyl cis-trans isomerase A ... 143 2e-34
sp|P62935|PPIA_BOVIN Peptidyl-prolyl cis-trans isomerase A ... 142 2e-34
sp|P14088|CYPH_ECHGR Peptidyl-prolyl cis-trans isomerase (P... 141 5e-34
sp|P17742|PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A ... 140 9e-34
sp|P30405|PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase, m... 140 1e-33
>sp|P54985|CYPH_BLAGE Peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase)
(Cyclophilin) (Cyclosporin A-binding protein)
Length = 164
Score = 147 bits (371), Expect = 1e-35
Identities = 73/143 (51%), Positives = 90/143 (62%)
Frame = +1
Query: 1 RCFMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXX 180
R F + DG+ G++V EL D+ PKT ENFR LCTGEKGFGYK S+ H VIP M
Sbjct: 5 RVFFDMSADGQPVGRIVMELRSDVVPKTAENFRALCTGEKGFGYKGSRFHRVIPNFMCQG 64
Query: 181 XXXXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNG 360
SIYG FEDENF++KHT PG+L M + PN+N SQFFIT + L+
Sbjct: 65 GDFTNHNGTGGKSIYGTKFEDENFQLKHTGPGILWMANAGPNTNGSQFFITTAKTSWLDN 124
Query: 361 KSVVFAKVVEGLEVVRFLEVFGS 429
+ VVF VVEG++VV+ LE GS
Sbjct: 125 RHVVFGSVVEGMDVVKKLESLGS 147
>sp|P91791|CYPH_HEMPU Peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase)
(Cyclophilin) (Cyclosporin A-binding protein)
Length = 164
Score = 147 bits (371), Expect = 1e-35
Identities = 70/141 (49%), Positives = 91/141 (64%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
F + + +G+N G++V EL D+ PKT ENFR LCTGEKGFGYK S H VIPG M
Sbjct: 7 FFDLQANGENLGRIVMELRADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPGFMCQGGD 66
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYGE F DENF +KHTQPG+L+M + N+N SQFFI + L+GK
Sbjct: 67 FTRHNGTGGKSIYGEKFADENFTLKHTQPGILSMANAGVNTNGSQFFICTAVTSWLDGKH 126
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF V +GL++++ +E +GS
Sbjct: 127 VVFGAVTQGLDIIKKVESYGS 147
>sp|P14851|PPIA_CRIGR Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
Length = 164
Score = 144 bits (362), Expect = 1e-34
Identities = 73/141 (51%), Positives = 88/141 (62%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
F + DG+ G+V FEL D PKT ENFR L TGEKGFGYK S H +IPG M
Sbjct: 7 FFDISADGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGD 66
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYGE FEDENF +KHT PG+L+M + PN+N SQFFI + + L+GK
Sbjct: 67 FTRHNGTGGRSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF KV EG+ +V +E FGS
Sbjct: 127 VVFGKVKEGMNIVEAMERFGS 147
>sp|P10111|PPIA_RAT Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein) (P31)
(p1B15)
Length = 164
Score = 144 bits (362), Expect = 1e-34
Identities = 73/141 (51%), Positives = 88/141 (62%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
F + DG+ G+V FEL D PKT ENFR L TGEKGFGYK S H +IPG M
Sbjct: 7 FFDITADGEPLGRVCFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGD 66
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYGE FEDENF +KHT PG+L+M + PN+N SQFFI + + L+GK
Sbjct: 67 FTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF KV EG+ +V +E FGS
Sbjct: 127 VVFGKVKEGMSIVEAMERFGS 147
>sp|P62937|PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
sp|P62941|PPIA_PAPAN Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
sp|P62940|PPIA_MACMU Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
sp|P62938|PPIA_CERAE Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
Length = 165
Score = 144 bits (362), Expect = 1e-34
Identities = 74/141 (52%), Positives = 89/141 (63%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
F + VDG+ G+V FEL D PKT ENFR L TGEKGFGYK S H +IPG M
Sbjct: 7 FFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGD 66
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYGE FEDENF +KHT PG+L+M + PN+N SQFFI + + L+GK
Sbjct: 67 FTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF KV EG+ +V +E FGS
Sbjct: 127 VVFGKVKEGMNIVEAMERFGS 147
>sp|Q9TTC6|PPIA_RABIT Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
(Cyclophilin 18)
Length = 164
Score = 143 bits (360), Expect = 2e-34
Identities = 73/141 (51%), Positives = 89/141 (63%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
F + VDG+ G+V FEL D PKT ENFR L TGEKGFGYK S H +IPG M
Sbjct: 7 FFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGD 66
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYGE FEDENF +KHT PG+L+M + PN+N SQFFI + + L+GK
Sbjct: 67 FTRHNGTGGKSIYGEKFEDENFLLKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF +V EG+ +V +E FGS
Sbjct: 127 VVFGRVKEGMSIVEAMEHFGS 147
>sp|P62935|PPIA_BOVIN Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
sp|P62936|PPIA_PIG Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein)
Length = 164
Score = 142 bits (359), Expect = 2e-34
Identities = 73/141 (51%), Positives = 89/141 (63%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
F + VDG+ G+V FEL D PKT ENFR L TGEKGFGYK S H +IPG M
Sbjct: 7 FFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGD 66
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYGE F+DENF +KHT PG+L+M + PN+N SQFFI + + L+GK
Sbjct: 67 FTRHNGTGGKSIYGEKFDDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF KV EG+ +V +E FGS
Sbjct: 127 VVFGKVKEGMNIVEAMERFGS 147
>sp|P14088|CYPH_ECHGR Peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase)
(Cyclophilin) (Cyclosporin A-binding protein) (EGCyP-1)
Length = 162
Score = 141 bits (356), Expect = 5e-34
Identities = 72/143 (50%), Positives = 89/143 (62%)
Frame = +1
Query: 1 RCFMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXX 180
+CF + + GK G++VF L FD PKT ENFR LCTGEKGFGYK SK H +IPG M
Sbjct: 4 KCFFDISIGGKPAGRIVFAL-FDDVPKTVENFRALCTGEKGFGYKGSKFHRIIPGFMCQG 62
Query: 181 XXXXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNG 360
SIYG FEDENF KH++P ML+M + N+N SQFFIT + L+G
Sbjct: 63 GDFTAGNGTGGKSIYGSKFEDENFNHKHSKPMMLSMANAGKNTNGSQFFITTAVTSWLDG 122
Query: 361 KSVVFAKVVEGLEVVRFLEVFGS 429
K VVF +V G +VV+ +E GS
Sbjct: 123 KHVVFGEVESGEDVVKDMEAVGS 145
>sp|P17742|PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A (PPIase) (Rotamase)
(Cyclophilin A) (Cyclosporin A-binding protein) (SP18)
Length = 164
Score = 140 bits (354), Expect = 9e-34
Identities = 72/141 (51%), Positives = 87/141 (61%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
F + D + G+V FEL D PKT ENFR L TGEKGFGYK S H +IPG M
Sbjct: 7 FFDITADDEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSSFHRIIPGFMCQGGD 66
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYGE FEDENF +KHT PG+L+M + PN+N SQFFI + + L+GK
Sbjct: 67 FTRHNGTGGRSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKH 126
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF KV EG+ +V +E FGS
Sbjct: 127 VVFGKVKEGMNIVEAMERFGS 147
>sp|P30405|PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase, mitochondrial precursor
(PPIase) (Rotamase) (Cyclophilin F)
Length = 207
Score = 140 bits (353), Expect = 1e-33
Identities = 70/141 (49%), Positives = 87/141 (61%)
Frame = +1
Query: 7 FMEFEVDGKNHGKVVFELSFDICPKTCENFRCLCTGEKGFGYKNSKIHAVIPGNMIXXXX 186
+++ + +GK G+VV EL D+ PKT ENFR LCTGEKGFGYK S H VIP M
Sbjct: 49 YLDVDANGKPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGD 108
Query: 187 XXXXXXXXXXSIYGETFEDENFRIKHTQPGMLAMVSKEPNSNNSQFFITLSAAKQLNGKS 366
SIYG F DENF +KH PG+L+M + PN+N SQFFI L+GK
Sbjct: 109 FTNHNGTGGKSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKH 168
Query: 367 VVFAKVVEGLEVVRFLEVFGS 429
VVF V EG++VV+ +E FGS
Sbjct: 169 VVFGHVKEGMDVVKKIESFGS 189
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,217,164
Number of Sequences: 369166
Number of extensions: 843981
Number of successful extensions: 2362
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2252
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2295
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2244666600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)