Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02621
(531 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P10634|CP2D2_RAT Cytochrome P450 2D2 (CYPIID2) (P450-DB2... 135 8e-32
sp|P12938|CP2D3_RAT Cytochrome P450 2D3 (CYPIID3) (P450-DB3... 134 2e-31
sp|Q6VVW9|CP2R1_MOUSE Cytochrome P450 2R1 (Vitamin D 25-hyd... 132 5e-31
sp|P13108|CP2D4_RAT Cytochrome P450 2D4 (CYPIID4) (P450-DB4... 132 7e-31
sp|Q29473|CP2DF_CANFA Cytochrome P450 2D15 (CYPIID15) (P450... 130 2e-30
sp|O55071|CP2BJ_MOUSE Cytochrome P450 2B19 (CYPIIB19) 130 2e-30
sp|Q29488|CP2DH_MACFA Cytochrome P450 2D17 (CYPIID17) 130 2e-30
sp|Q64403|CP2DG_CAVPO Cytochrome P450 2D16 (CYPIID16) 129 4e-30
sp|P13107|CP2B3_RAT Cytochrome P450 2B3 (CYPIIB3) 129 6e-30
sp|O46658|CP2DP_PIG Cytochrome P450 2D25 (CYPIID25) (Vitami... 129 6e-30
>sp|P10634|CP2D2_RAT Cytochrome P450 2D2 (CYPIID2) (P450-DB2) (P450-CMF2) (Debrisoquine
4-hydroxylase)
Length = 500
Score = 135 bits (339), Expect = 8e-32
Identities = 72/172 (41%), Positives = 99/172 (57%), Gaps = 1/172 (0%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVES-FTEWQLIRNALELFIAGYETTSTTL 178
H K+ D D+ D FL + + K GN ES F + L ++LF+AG TTSTTL
Sbjct: 261 HKKSWDPAQPPRDMTDAFLAEMQKAK---GNPESSFNDENLRLVVIDLFMAGMVTTSTTL 317
Query: 179 CWSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLAL 358
W+ L M H D+Q++VH EI E+IG+ R P M D+ M +T AV+ E+ R + + P +
Sbjct: 318 SWALLLMILHPDVQRRVHEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNI 377
Query: 359 IHRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFLSEDDN 514
H T D G+ IPK T + PNL + DE +WEKP+ F+PEHFL N
Sbjct: 378 PHMTSRDIKFQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGN 429
>sp|P12938|CP2D3_RAT Cytochrome P450 2D3 (CYPIID3) (P450-DB3) (Debrisoquine
4-hydroxylase)
Length = 500
Score = 134 bits (336), Expect = 2e-31
Identities = 74/172 (43%), Positives = 99/172 (57%), Gaps = 1/172 (0%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVES-FTEWQLIRNALELFIAGYETTSTTL 178
H KT D D DL D FL ++++ GN ES F + L +LF AG TTS TL
Sbjct: 261 HKKTWDPDQPPRDLTDAFLA---EIEKAKGNPESSFNDANLRLVVNDLFGAGMVTTSITL 317
Query: 179 CWSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLAL 358
W+ L M H D+Q +V EI E+IG+ R P M D+ M +T AV+ E+ R + + P+ L
Sbjct: 318 TWALLLMILHPDVQCRVQQEIDEVIGQVRHPEMADQAHMPFTNAVIHEVQRFADIVPMNL 377
Query: 359 IHRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFLSEDDN 514
H+T D V G+ IPK T + PNL + DE +WEKP+ F+PEHFL N
Sbjct: 378 PHKTSRDIEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGN 429
>sp|Q6VVW9|CP2R1_MOUSE Cytochrome P450 2R1 (Vitamin D 25-hydroxylase)
Length = 501
Score = 132 bits (332), Expect = 5e-31
Identities = 67/145 (46%), Positives = 91/145 (62%)
Frame = +2
Query: 83 QNGNVESFTEWQLIRNALELFIAGYETTSTTLCWSFLFMSKHQDIQQKVHNEIIEIIGKE 262
QN + +F++ LI + EL IAG ETT+ L W+ LFM+ + +IQ +VH EI I+G
Sbjct: 288 QNDPLSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVHKEIDLIVGHN 347
Query: 263 RLPTMNDKKSMNYTQAVMDEIFRMSSVAPLALIHRTLDDANVDGYFIPKNTLIFPNLYAC 442
R P+ K M YT+AV+ E+ R ++ PL + H T +DA V GY IPK T + NLY+
Sbjct: 348 RRPSWEYKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSV 407
Query: 443 HFDEDIWEKPMIFYPEHFLSEDDNG 517
HFDE W+ P +FYPE FL D NG
Sbjct: 408 HFDEKYWKDPDMFYPERFL--DSNG 430
>sp|P13108|CP2D4_RAT Cytochrome P450 2D4 (CYPIID4) (P450-DB4) (P450-CMF3) (Debrisoquine
4-hydroxylase)
Length = 500
Score = 132 bits (331), Expect = 7e-31
Identities = 74/172 (43%), Positives = 98/172 (56%), Gaps = 1/172 (0%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVES-FTEWQLIRNALELFIAGYETTSTTL 178
H T D DL D FL + + K GN ES F + L +LF+AG TTSTTL
Sbjct: 261 HKVTWDPAQPPRDLTDAFLAEVEKAK---GNPESSFNDENLRVVVADLFMAGMVTTSTTL 317
Query: 179 CWSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLAL 358
W+ LFM H D+Q +V EI E+IG+ R P M D+ M +T AV+ E+ R + + PL +
Sbjct: 318 TWALLFMILHPDVQCRVQQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGV 377
Query: 359 IHRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFLSEDDN 514
H+T D V G+ IPK T + NL + DE +WEKP+ F+PEHFL N
Sbjct: 378 PHKTSRDIEVQGFLIPKGTTLITNLSSVLKDETVWEKPLRFHPEHFLDAQGN 429
>sp|Q29473|CP2DF_CANFA Cytochrome P450 2D15 (CYPIID15) (P450 DUT2)
Length = 500
Score = 130 bits (328), Expect = 2e-30
Identities = 70/167 (41%), Positives = 97/167 (58%), Gaps = 1/167 (0%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVE-SFTEWQLIRNALELFIAGYETTSTTL 178
H KT D L+D F+ ++++ GN + SF E L +LFIAG +TS TL
Sbjct: 261 HRKTRDPTQPPRHLIDAFV---DEIEKAKGNPKTSFNEENLCMVTSDLFIAGMVSTSITL 317
Query: 179 CWSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLAL 358
W+ L M H D+Q++V EI E+IG+E+LP M D+ M +T AV+ E+ R + PL +
Sbjct: 318 TWALLLMILHPDVQRRVQQEIDEVIGREQLPEMGDQTRMPFTVAVIHEVQRFGDIVPLGV 377
Query: 359 IHRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFL 499
H T D V G+ IPK T + NL + DE +W+KP FYPEHFL
Sbjct: 378 PHMTSRDTEVQGFLIPKGTTLITNLSSVLKDEKVWKKPFRFYPEHFL 424
>sp|O55071|CP2BJ_MOUSE Cytochrome P450 2B19 (CYPIIB19)
Length = 492
Score = 130 bits (327), Expect = 2e-30
Identities = 73/175 (41%), Positives = 104/175 (59%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVESFTEWQLIRNALELFIAGYETTSTTLC 181
H T+D S D +D +L++ K+++ + F L+ + L LF AG ETTSTTL
Sbjct: 253 HRATLD-PSAPRDFIDTYLLRME--KEKSNHHTEFHHQNLVISVLSLFFAGTETTSTTLR 309
Query: 182 WSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLALI 361
+SFL M K+ + +KV EI ++IG RLPT++D+ M YT AV+ EI R + +AP+ L
Sbjct: 310 YSFLIMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFTDLAPIGLP 369
Query: 362 HRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFLSEDDNGNIK 526
H+ D GY IPKNT ++P L + D +E+P F PEHFL D NG +K
Sbjct: 370 HKVTKDTLFRGYLIPKNTEVYPILSSALHDPRYFEQPDSFNPEHFL--DANGALK 422
>sp|Q29488|CP2DH_MACFA Cytochrome P450 2D17 (CYPIID17)
Length = 497
Score = 130 bits (327), Expect = 2e-30
Identities = 72/167 (43%), Positives = 93/167 (55%), Gaps = 1/167 (0%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVES-FTEWQLIRNALELFIAGYETTSTTL 178
H T D DL + FL + + K GN ES F E L +LF AG TTSTTL
Sbjct: 258 HRMTWDPAQPPRDLTEAFLAEMEKAK---GNPESSFNEENLRMVVADLFSAGMVTTSTTL 314
Query: 179 CWSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLAL 358
W L M H D+Q++V EI ++IG+ R P M D+ M YT AV+ E+ R + PL +
Sbjct: 315 AWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQARMPYTTAVIHEVQRFGDIVPLGV 374
Query: 359 IHRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFL 499
H T D + G+ IPK T +F NL + DE +WEKP F+PEHFL
Sbjct: 375 THMTSRDIELQGFLIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHFL 421
>sp|Q64403|CP2DG_CAVPO Cytochrome P450 2D16 (CYPIID16)
Length = 500
Score = 129 bits (324), Expect = 4e-30
Identities = 67/162 (41%), Positives = 92/162 (56%)
Frame = +2
Query: 23 DSEGEDLMDRFLIKQHQLKQQNGNVESFTEWQLIRNALELFIAGYETTSTTLCWSFLFMS 202
D DL D FL + H K Q + SF + L +LF AG TTS TL W+ L M
Sbjct: 268 DQPPRDLTDAFLTEMH--KAQGNSESSFNDENLRLLVSDLFGAGMVTTSVTLSWALLLMI 325
Query: 203 KHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLALIHRTLDDA 382
H D+Q+ V EI E+IG+ R P M D+ M +T AV+ E+ R + + P+ + H T D
Sbjct: 326 LHPDVQRHVQEEIDEVIGQVRCPEMADQAHMPFTNAVIHEVQRFADIVPMGVPHMTSRDT 385
Query: 383 NVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFLSED 508
V G+ IPK T++F NL + DE +WEKP+ F+P HFL +
Sbjct: 386 EVQGFLIPKGTMLFTNLSSVLKDETVWEKPLHFHPGHFLDAE 427
>sp|P13107|CP2B3_RAT Cytochrome P450 2B3 (CYPIIB3)
Length = 491
Score = 129 bits (323), Expect = 6e-30
Identities = 71/175 (40%), Positives = 105/175 (60%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVESFTEWQLIRNALELFIAGYETTSTTLC 181
H T+D ++ D +D FL+ H K++ + F W L+ + L LF+AG E+TS TLC
Sbjct: 252 HRATLDPNAP-RDFIDTFLL--HMEKEKLNHYTEFHHWNLMISVLFLFLAGTESTSNTLC 308
Query: 182 WSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLALI 361
+ FL M K+ + +KV EI ++IG +R+PT++D+ M YT+AV+ EI R S V+P+ L
Sbjct: 309 YGFLLMLKYPHVAEKVQKEIDQVIGSQRVPTLDDRSKMPYTEAVIHEIQRFSDVSPMGLP 368
Query: 362 HRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFLSEDDNGNIK 526
R D GY +PKNT ++ L + D +E+P F PEHFL D NG +K
Sbjct: 369 CRITKDTLFRGYLLPKNTEVYFILSSALHDPQYFEQPDTFNPEHFL--DANGALK 421
>sp|O46658|CP2DP_PIG Cytochrome P450 2D25 (CYPIID25) (Vitamin D(3) 25-hydroxylase)
Length = 500
Score = 129 bits (323), Expect = 6e-30
Identities = 71/167 (42%), Positives = 92/167 (55%), Gaps = 1/167 (0%)
Frame = +2
Query: 2 HLKTIDFDSEGEDLMDRFLIKQHQLKQQNGNVES-FTEWQLIRNALELFIAGYETTSTTL 178
H T D DL D FL ++K+ GN ES F + L LF AG TTSTTL
Sbjct: 261 HKMTRDLAQPPRDLTDAFL---DEMKEAKGNPESSFNDENLRLVVAHLFSAGMITTSTTL 317
Query: 179 CWSFLFMSKHQDIQQKVHNEIIEIIGKERLPTMNDKKSMNYTQAVMDEIFRMSSVAPLAL 358
W+ L M H D+Q++V EI E+IG R P + D+ M +T AV+ E+ R + PL +
Sbjct: 318 AWALLLMILHPDVQRRVQQEIDEVIGHVRQPEIKDQALMPFTLAVLHEVQRFGDIVPLGV 377
Query: 359 IHRTLDDANVDGYFIPKNTLIFPNLYACHFDEDIWEKPMIFYPEHFL 499
H T D V G+ IPK T + NL + DE +W+KP FYPEHFL
Sbjct: 378 AHMTSCDIEVQGFLIPKGTTLITNLTSVLKDETVWKKPFRFYPEHFL 424
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,044,955
Number of Sequences: 369166
Number of extensions: 1058921
Number of successful extensions: 3479
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3181
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3238
length of database: 68,354,980
effective HSP length: 103
effective length of database: 49,327,275
effective search space used: 3600891075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)