Planaria EST Database


DrC_02596

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_02596
         (685 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|P55735|SEC13_HUMAN  SEC13-related protein (SEC13-like pro...   238   1e-62
sp|Q9D1M0|SEC13_MOUSE  SEC13-related protein (SEC13-like pro...   236   4e-62
sp|Q04491|SEC13_YEAST  Protein transport protein SEC13            179   5e-45
sp|P53024|SEC13_PICPA  Protein transport protein SEC13            164   2e-40
sp|Q10099|SEH1_SCHPO  Nuclear pore protein SEH1 homolog            68   2e-11
sp|Q00808|HETE1_PODAN  Vegetatible incompatibility protein H...    61   2e-09
sp|O76071|WDR39_HUMAN  WD-repeat protein 39 (Ciao 1 protein)       61   2e-09
sp|Q9NVX2|NLE1_HUMAN  Notchless homolog 1                          61   2e-09
sp|Q5RFF8|NLE1_PONPY  Notchless homolog 1                          61   2e-09
sp|Q8VEJ4|NLE1_MOUSE  Notchless homolog 1                          59   2e-08
>sp|P55735|SEC13_HUMAN SEC13-related protein (SEC13-like protein 1)
          Length = 322

 Score =  238 bits (606), Expect = 1e-62
 Identities = 112/215 (52%), Positives = 147/215 (68%), Gaps = 7/215 (3%)
 Frame = +2

Query: 8   EYCNHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVW 187
           E+  HDSSVNS+CW+P +YG +LACGSSDG++S++T  G+G  + KK+++AH IG N+V 
Sbjct: 98  EHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVS 157

Query: 188 WAPA----TFIEDAEGEK--VIKRLVSGGCDGEVKIWK-ETGGRWVEETVLRGHSDWVRD 346
           WAPA    + I+   G+K   IKR  SGGCD  +K+WK E  G+W EE  L  HSDWVRD
Sbjct: 158 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 217

Query: 347 VAWCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDI 526
           VAW P        IASC Q G V IWT   +  +N W    L  F  VVWH+SWS+T +I
Sbjct: 218 VAWAPSIGLPTSTIASCSQDGRVFIWT-CDDASSNTWSPKLLHKFNDVVWHVSWSITANI 276

Query: 527 LAVSSGDNNISLWKQNLEGQWACISAVNQGEGDIS 631
           LAVS GDN ++LWK++++GQW CIS VN+G+G +S
Sbjct: 277 LAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 46/142 (32%), Positives = 60/142 (42%), Gaps = 3/142 (2%)
 Frame = +2

Query: 173 INSVWWAPATFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVA 352
           IN+V  +    I DA+ +    RL +   D  VKI+    G  +    LRGH   V  VA
Sbjct: 5   INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64

Query: 353 WCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPV-FPQVVWHLSWSV--TGD 523
           W      N  I+ASC     V IW +     N  W+++         V  + W+    G 
Sbjct: 65  WAHPMYGN--ILASCSYDRKVIIWREE----NGTWEKSHEHAGHDSSVNSVCWAPHDYGL 118

Query: 524 ILAVSSGDNNISLWKQNLEGQW 589
           ILA  S D  ISL     EGQW
Sbjct: 119 ILACGSSDGAISLLTYTGEGQW 140

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 51/194 (26%), Positives = 74/194 (38%), Gaps = 18/194 (9%)
 Frame = +2

Query: 62  YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
           YG  LA  SSD S+ I  +   G      +   H   +  V WA   +            
Sbjct: 24  YGTRLATCSSDRSVKIFDVRNGGQILIADLR-GHEGPVWQVAWAHPMYGNI--------- 73

Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNI 421
           L S   D +V IW+E  G W +     GH   V  V W P       I+A     G +++
Sbjct: 74  LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP--HDYGLILACGSSDGAISL 131

Query: 422 WTQSAEHGNNQWQQTCLPVFPQVVWH-LSWS---VTGDILAVSSG--------------D 547
            T +   G  QW+   +     +  + +SW+   V G ++   SG              D
Sbjct: 132 LTYT---GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 188

Query: 548 NNISLWKQNLEGQW 589
           N I LWK+  +GQW
Sbjct: 189 NLIKLWKEEEDGQW 202
>sp|Q9D1M0|SEC13_MOUSE SEC13-related protein (SEC13-like protein 1)
          Length = 322

 Score =  236 bits (602), Expect = 4e-62
 Identities = 111/215 (51%), Positives = 146/215 (67%), Gaps = 7/215 (3%)
 Frame = +2

Query: 8   EYCNHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVW 187
           E+  HDSSVNS+CW+P +YG +LACGSSDG++S++T  G+G  + KK+++AH IG N+V 
Sbjct: 98  EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVS 157

Query: 188 WAPA----TFIEDAEGEK--VIKRLVSGGCDGEVKIWK-ETGGRWVEETVLRGHSDWVRD 346
           WAPA    + I+   G+K   IK+  SGGCD  +K+W+ E  G+W EE  L  HSDWVRD
Sbjct: 158 WAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217

Query: 347 VAWCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDI 526
           VAW P        IASC Q G V IWT     G N W    L  F  VVWH+SWS+T +I
Sbjct: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG-NMWSPKLLHKFNDVVWHVSWSITANI 276

Query: 527 LAVSSGDNNISLWKQNLEGQWACISAVNQGEGDIS 631
           LAVS GDN ++LWK++++GQW CIS VN+G+G +S
Sbjct: 277 LAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 51/194 (26%), Positives = 74/194 (38%), Gaps = 18/194 (9%)
 Frame = +2

Query: 62  YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
           YG  LA  SSD S+ I  +   G      +   H   +  V WA   +            
Sbjct: 24  YGTRLATCSSDRSVKIFDVRNGGQILIADLR-GHEGPVWQVAWAHPMYGNI--------- 73

Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNI 421
           L S   D +V IWKE  G W +     GH   V  V W P       I+A     G +++
Sbjct: 74  LASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP--HDYGLILACGSSDGAISL 131

Query: 422 WTQSAEHGNNQWQQTCLPVFPQVVWH-LSWS---VTGDILAVSSG--------------D 547
            T +   G  QW+   +     +  + +SW+   V G ++   SG              D
Sbjct: 132 LTYT---GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188

Query: 548 NNISLWKQNLEGQW 589
           N I LW++  +GQW
Sbjct: 189 NLIKLWREEEDGQW 202

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 46/142 (32%), Positives = 60/142 (42%), Gaps = 3/142 (2%)
 Frame = +2

Query: 173 INSVWWAPATFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVA 352
           +N+V  +    I DA+ +    RL +   D  VKI+    G  +    LRGH   V  VA
Sbjct: 5   MNTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64

Query: 353 WCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTC-LPVFPQVVWHLSWSV--TGD 523
           W      N  I+ASC     V IW +     N  W++T         V  + W+    G 
Sbjct: 65  WAHPMYGN--ILASCSYDRKVIIWKEE----NGTWEKTHEHSGHDSSVNSVCWAPHDYGL 118

Query: 524 ILAVSSGDNNISLWKQNLEGQW 589
           ILA  S D  ISL     EGQW
Sbjct: 119 ILACGSSDGAISLLTYTGEGQW 140
>sp|Q04491|SEC13_YEAST Protein transport protein SEC13
          Length = 297

 Score =  179 bits (455), Expect = 5e-45
 Identities = 96/204 (47%), Positives = 125/204 (61%), Gaps = 6/204 (2%)
 Frame = +2

Query: 20  HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
           H +SVNS+ W+P EYGP+L   SSDG +S++    +G      + DAH IG+NS  WAPA
Sbjct: 98  HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPA 156

Query: 200 TFIEDAE--GEKVIKRLVSGGCDGEVKIWKETGGR--WVEETVLRGHSDWVRDVAWCPIT 367
           T  ED E  G K  ++ V+GG D  VKIWK       +V E+ L GHSDWVRDVAW P T
Sbjct: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP-T 215

Query: 368 SSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPV--FPQVVWHLSWSVTGDILAVSS 541
                 +AS  Q     IWTQ  E G   W++T L    FP V+W  SWS++G++LA+S 
Sbjct: 216 VLLRSYLASVSQDRTCIIWTQDNEQG--PWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273

Query: 542 GDNNISLWKQNLEGQWACISAVNQ 613
           GDN ++LWK+NLEG+W     V+Q
Sbjct: 274 GDNKVTLWKENLEGKWEPAGEVHQ 297

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 52/201 (25%), Positives = 74/201 (36%), Gaps = 13/201 (6%)
 Frame = +2

Query: 62  YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
           YG  LA  SSD ++ I  + G+ +    K+ D        VW        D    K    
Sbjct: 20  YGKRLATCSSDKTIKIFEVEGETH----KLIDTLTGHEGPVWRV------DWAHPKFGTI 69

Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNI 421
           L S   DG+V IWKE  GRW +  V   HS  V  V W P       ++AS D  G V++
Sbjct: 70  LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD--GKVSV 127

Query: 422 WTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVT-------------GDILAVSSGDNNISL 562
             +  E+G        +      V   SW+                        DN + +
Sbjct: 128 -VEFKENGTT--SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184

Query: 563 WKQNLEGQWACISAVNQGEGD 625
           WK N + Q   + +  +G  D
Sbjct: 185 WKYNSDAQTYVLESTLEGHSD 205

 Score = 38.9 bits (89), Expect = 0.013
 Identities = 38/128 (29%), Positives = 55/128 (42%), Gaps = 5/128 (3%)
 Frame = +2

Query: 206 IEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQI 385
           I DA  +   KRL +   D  +KI++  G        L GH   V  V W         I
Sbjct: 12  IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT--I 69

Query: 386 IASCDQTGHVNIWTQSAEHGNNQWQQTCL-PVFPQVVWHLSWS--VTGDILAVSSGDNNI 556
           +ASC   G V IW +     N +W Q  +  V    V  + W+    G +L V+S D  +
Sbjct: 70  LASCSYDGKVLIWKEE----NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125

Query: 557 SL--WKQN 574
           S+  +K+N
Sbjct: 126 SVVEFKEN 133
>sp|P53024|SEC13_PICPA Protein transport protein SEC13
          Length = 289

 Score =  164 bits (416), Expect = 2e-40
 Identities = 87/206 (42%), Positives = 124/206 (60%), Gaps = 4/206 (1%)
 Frame = +2

Query: 8   EYCNHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVW 187
           E+  H +SVNS+ W+P EYGP+L C SSDG +SI+    DG      V   H IG N+  
Sbjct: 94  EHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFK-DGGALEPIVIQGHAIGGNAAS 152

Query: 188 WAPATFIEDAEGEKVIKRLVSGGCDGEVKIWK--ETGGRWVEETVLRGHSDWVRDVAWCP 361
           WAP +  ++       +R VSGGCD  VKIW+  +    ++EE   +GHSDWVRDVAW P
Sbjct: 153 WAPISLPDNT------RRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSP 206

Query: 362 ITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPV--FPQVVWHLSWSVTGDILAV 535
              S +  IA+  Q   V IWT+  +  +N+W++  L    FP V W  SWS++G++LA+
Sbjct: 207 SRLS-KSYIATASQDRTVLIWTKDGK--SNKWEKQPLTKEKFPDVCWRASWSLSGNVLAI 263

Query: 536 SSGDNNISLWKQNLEGQWACISAVNQ 613
           S GDN ++L K+N++G+W     V+Q
Sbjct: 264 SGGDNKVTLSKENIQGKWESAGEVDQ 289

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 37/113 (32%), Positives = 46/113 (40%)
 Frame = +2

Query: 62  YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
           YG  LA  SSD ++ I  I G+ N    +    H   +  V WA   F        VI  
Sbjct: 20  YGRRLATCSSDKTIKIFEIDGE-NQRLVETLIGHEGPVWQVAWAHPKF-------GVI-- 69

Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCD 400
           L S   DG+V IWKE  G W +      H   V  V+W P       + AS D
Sbjct: 70  LASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSD 122

 Score = 35.8 bits (81), Expect = 0.11
 Identities = 36/122 (29%), Positives = 50/122 (40%), Gaps = 3/122 (2%)
 Frame = +2

Query: 206 IEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQI 385
           I DA  +   +RL +   D  +KI++  G        L GH   V  VAW         I
Sbjct: 12  IHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWA--HPKFGVI 69

Query: 386 IASCDQTGHVNIWTQSAEHGNNQWQQTC-LPVFPQVVWHLSWS--VTGDILAVSSGDNNI 556
           +ASC   G V IW +     N  W +     V    V  +SW+    G +L  +S D  I
Sbjct: 70  LASCSYDGKVLIWKED----NGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 125

Query: 557 SL 562
           S+
Sbjct: 126 SI 127
>sp|Q10099|SEH1_SCHPO Nuclear pore protein SEH1 homolog
          Length = 339

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 55/229 (24%), Positives = 99/229 (43%), Gaps = 34/229 (14%)
 Frame = +2

Query: 26  SSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINS-------- 181
           S+V  I + P ++G  LA  S+D ++ I   +  GN  Y  + +   +  +         
Sbjct: 112 SAVLDISFCPFQHGCKLAAVSADATLRIYEAMEPGNLTYWTLMNEIALMPSPPSRNEQPA 171

Query: 182 --VWWAPATFIEDAEGEKVIKRLVSGGCDGEVKIWKETG-GRWVEETVLRGHSDWVRDVA 352
             V W P+ + E         + ++ GC  +  I+K+   G+W +   L GH+D +RD+ 
Sbjct: 172 FCVNWCPSRWRE---------QYIAVGCMNDAYIYKQNSHGKWKKVAELPGHTDLIRDIC 222

Query: 353 WCPITSSNEQIIASCDQTGHVNIWT----------QSAEHGNNQWQQTCLPV-------- 478
           W P   S+  +IA+  + G+V I+           +  + GN+  + +   +        
Sbjct: 223 WAPSMGSSYYLIATACKDGNVRIFKVETLCEEVFQEEEDAGNSMTEDSNFNLNSLKVELI 282

Query: 479 -----FPQVVWHLSWSVTGDILAVSSGDNNISLWKQNLEGQWACISAVN 610
                    VW   ++VTG IL+ S  D  + LWK +    + CIS V+
Sbjct: 283 GEYDNHKCQVWRCRFNVTGTILSSSGDDGCVRLWKASYANLFKCISVVS 331

 Score = 29.6 bits (65), Expect = 7.7
 Identities = 46/214 (21%), Positives = 75/214 (35%), Gaps = 23/214 (10%)
 Frame = +2

Query: 17  NHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSD--AHNIGINSVWW 190
           NH   VN + +    YG  +   S+D  + +     D    +   S+  A +  +  V W
Sbjct: 12  NHQDLVNDVTYD--FYGRRMVSCSADQRVKVYDF-NDDTETWAITSEWRAGDASLMRVAW 68

Query: 191 APATFIEDAEGEKVIKRLVSGGCDGEVKIWKET-----GGRWVEETVLRGHSDWVRDVAW 355
           A  +F +          L     D  V+I++E         WVE   L      V D+++
Sbjct: 69  AHPSFGQV---------LAVCSLDRGVRIYEEQKKNFESKTWVEVAKLMDARSAVLDISF 119

Query: 356 CPITSSNEQIIASCDQT---------GHVNIWTQSAE-------HGNNQWQQTCLPVFPQ 487
           CP     +    S D T         G++  WT   E          N+    C+   P 
Sbjct: 120 CPFQHGCKLAAVSADATLRIYEAMEPGNLTYWTLMNEIALMPSPPSRNEQPAFCVNWCPS 179

Query: 488 VVWHLSWSVTGDILAVSSGDNNISLWKQNLEGQW 589
             W   +   G +       N+  ++KQN  G+W
Sbjct: 180 -RWREQYIAVGCM-------NDAYIYKQNSHGKW 205
>sp|Q00808|HETE1_PODAN Vegetatible incompatibility protein HET-E-1
          Length = 1356

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 58/206 (28%), Positives = 88/206 (42%), Gaps = 7/206 (3%)
 Frame = +2

Query: 20   HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
            H  SV S+ +SP   G  +A GS DG+   I I    +    +  + H   ++SV ++P 
Sbjct: 1092 HGDSVWSVAFSPD--GQRVASGSIDGT---IKIWDAASGTCTQTLEGHGGWVHSVAFSP- 1145

Query: 200  TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
                  +G++V     SG  DG +KIW    G   +   L GH  WV+ VA+ P    + 
Sbjct: 1146 ------DGQRV----ASGSIDGTIKIWDAASGTCTQ--TLEGHGGWVQSVAFSP----DG 1189

Query: 380  QIIASCDQTGHVNIW-------TQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVS 538
            Q +AS      + IW       TQ+ E G+  W Q+           +++S  G  +A  
Sbjct: 1190 QRVASGSSDKTIKIWDTASGTCTQTLE-GHGGWVQS-----------VAFSPDGQRVASG 1237

Query: 539  SGDNNISLWKQNLEGQWACISAVNQG 616
            S DN I +W         C   +N G
Sbjct: 1238 SSDNTIKIWD---TASGTCTQTLNVG 1260

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 65/238 (27%), Positives = 97/238 (40%), Gaps = 42/238 (17%)
 Frame = +2

Query: 20   HDSSVNSICWSPPEYGPMLACGSSDGSMSII---------TILGDG--------NPDYKK 148
            H SSV S+ +SP   G  +A GS D ++ I          T+ G G        +PD ++
Sbjct: 966  HGSSVLSVAFSPD--GQRVASGSGDKTIKIWDTASGTCTQTLEGHGGSVWSVAFSPDGQR 1023

Query: 149  VSDAHNIGINSVW-WAPATFIEDAEG-----EKVI-----KRLVSGGCDGEVKIWKETGG 295
            V+   +     +W  A  T  +  EG     + V+     +R+ SG  D  +KIW    G
Sbjct: 1024 VASGSDDKTIKIWDTASGTCTQTLEGHGGWVQSVVFSPDGQRVASGSDDHTIKIWDAVSG 1083

Query: 296  RWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIW-------TQSAEHGNNQ 454
               +   L GH D V  VA+ P    + Q +AS    G + IW       TQ+ E G+  
Sbjct: 1084 TCTQ--TLEGHGDSVWSVAFSP----DGQRVASGSIDGTIKIWDAASGTCTQTLE-GHGG 1136

Query: 455  WQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW-------KQNLEGQWACISAV 607
            W           V  +++S  G  +A  S D  I +W        Q LEG    + +V
Sbjct: 1137 W-----------VHSVAFSPDGQRVASGSIDGTIKIWDAASGTCTQTLEGHGGWVQSV 1183

 Score = 37.7 bits (86), Expect = 0.028
 Identities = 42/170 (24%), Positives = 64/170 (37%), Gaps = 23/170 (13%)
 Frame = +2

Query: 167  IGINSVWWAPATFIEDAEGEKVI--------KRLVSGGCDGEVKIWKETGGRWVEETVLR 322
            I +    W   T   +  G  V+        +R+ SG  D  +KIW    G   +   L 
Sbjct: 823  ISVVEAEWNACTQTLEGHGSSVLSVAFSADGQRVASGSDDKTIKIWDTASGTGTQ--TLE 880

Query: 323  GHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIW-------TQSAE-HGNNQWQQTCLPV 478
            GH   V  VA+ P    + + +AS      + IW       TQ+ E HG           
Sbjct: 881  GHGGSVWSVAFSP----DRERVASGSDDKTIKIWDAASGTCTQTLEGHGGR--------- 927

Query: 479  FPQVVWHLSWSVTGDILAVSSGDNNISLW-------KQNLEGQWACISAV 607
                V  +++S  G  +A  S D+ I +W        Q LEG  + + +V
Sbjct: 928  ----VQSVAFSPDGQRVASGSDDHTIKIWDAASGTCTQTLEGHGSSVLSV 973
>sp|O76071|WDR39_HUMAN WD-repeat protein 39 (Ciao 1 protein)
          Length = 339

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 1/133 (0%)
 Frame = +2

Query: 242 LVSGGCDGEVKIWKETGGRWVEETVL-RGHSDWVRDVAWCPITSSNEQIIASCDQTGHVN 418
           L S G D  ++IW   G  W+ ++VL  GH   VR VAW P    N    AS D T    
Sbjct: 31  LASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC--GNYLASASFDAT--TC 86

Query: 419 IWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQNLEGQWACI 598
           IW ++ +        T L      V  ++W+ +G++LA  S D ++ +W+ + E ++ C+
Sbjct: 87  IWKKNQDDFECV---TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143

Query: 599 SAVNQGEGDISNI 637
           S +N    D+ ++
Sbjct: 144 SVLNSHTQDVKHV 156

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 55/250 (22%), Positives = 84/250 (33%), Gaps = 54/250 (21%)
 Frame = +2

Query: 23  DSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPAT 202
           DS    + W+P   G +LA    D  + I    GD       +S+ H   +  V W+P  
Sbjct: 16  DSRCWFLAWNPA--GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG 73

Query: 203 FIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQ 382
                        L S   D    IWK+    +   T L GH + V+ VAW P    +  
Sbjct: 74  -----------NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP----SGN 118

Query: 383 IIASCDQTGHVNIW-----------------TQSAEH----------GNNQWQQTC---- 469
           ++A+C +   V +W                 TQ  +H           +  +  T     
Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178

Query: 470 -----------LPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQNLEG----------- 583
                      L      VW L++  +G  LA  S D  + +W+Q L G           
Sbjct: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSD 238

Query: 584 -QWACISAVN 610
             W CI  ++
Sbjct: 239 PSWKCICTLS 248

 Score = 35.4 bits (80), Expect = 0.14
 Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
 Frame = +2

Query: 494 WHLSWSVTGDILAVSSGDNNISLWKQNLEG-QWACISAVNQG 616
           W L+W+  G +LA   GD  I +W    EG  W C S +++G
Sbjct: 20  WFLAWNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEG 59

 Score = 34.7 bits (78), Expect = 0.24
 Identities = 54/248 (21%), Positives = 91/248 (36%), Gaps = 60/248 (24%)
 Frame = +2

Query: 20  HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
           H++ V S+ W+P   G +LA  S D S+ +  +  +   +   V ++H   +  V W P+
Sbjct: 104 HENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPS 161

Query: 200 T-FIEDAEGEKVIK--------------------------------RLVSGGCDGEVKIW 280
              +  A  +  +K                                RL S   D  V+IW
Sbjct: 162 QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221

Query: 281 KE-------------TGGRWVEETVLRG-HSDWVRDVAWCPITSSNEQIIASCDQTGHVN 418
           ++             +   W     L G HS  + D+AWC +T +    +A+      + 
Sbjct: 222 RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA----LATACGDDAIR 277

Query: 419 IWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDI------------LAVSSGDNNISL 562
           ++    E  N+  QQ   P F  +  HL  + + D+            LA  S D  ++ 
Sbjct: 278 VF---QEDPNSDPQQ---PTF-SLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAF 330

Query: 563 WK-QNLEG 583
           WK Q  EG
Sbjct: 331 WKYQRPEG 338
>sp|Q9NVX2|NLE1_HUMAN Notchless homolog 1
          Length = 485

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 53/184 (28%), Positives = 85/184 (46%), Gaps = 1/184 (0%)
 Frame = +2

Query: 20  HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
           H  +V S+ +SP   G  LA GS D ++     L    P +      H   + S+ W+P 
Sbjct: 113 HSEAVISVAFSPT--GKYLASGSGDTTVRFWD-LSTETPHF--TCKGHRHWVLSISWSP- 166

Query: 200 TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
                 +G    K+L SG  +G++ +W  + G+ V  T L GHS W+  ++W P+ ++ E
Sbjct: 167 ------DG----KKLASGCKNGQILLWDPSTGKQVGRT-LAGHSKWITGLSWEPLHANPE 215

Query: 380 -QIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNI 556
            + +AS  + G V IW  +A        +  L    Q V  L W   G +L  +S D  I
Sbjct: 216 CRYVASSSKDGSVRIWDTTAGR-----CERILTGHTQSVTCLRWGGDG-LLYSASQDRTI 269

Query: 557 SLWK 568
            +W+
Sbjct: 270 KVWR 273

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 38/166 (22%), Positives = 67/166 (40%)
 Frame = +2

Query: 74  LACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKRLVSG 253
           L  GS D ++ + +   D  P  +     H   IN V ++P + I           + S 
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTG--HQALINQVLFSPDSRI-----------VASA 390

Query: 254 GCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIWTQS 433
             D  +K+W    G+++    LRGH   V  +AW    S++ +++ S      + +W   
Sbjct: 391 SFDKSIKLWDGRTGKYLAS--LRGHVAAVYQIAW----SADSRLLVSGSSDSTLKVWDVK 444

Query: 434 AEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQ 571
           A     Q     LP     V+ + WS  G  +A    D  + +W++
Sbjct: 445 A-----QKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485

 Score = 33.9 bits (76), Expect = 0.41
 Identities = 25/110 (22%), Positives = 44/110 (40%)
 Frame = +2

Query: 236 KRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHV 415
           +RLVSG  D  + +W     +    T + GH   +  V + P    + +I+AS      +
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDK-KPLTRMTGHQALINQVLFSP----DSRIVASASFDKSI 396

Query: 416 NIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW 565
            +W      G        L      V+ ++WS    +L   S D+ + +W
Sbjct: 397 KLWD-----GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
>sp|Q5RFF8|NLE1_PONPY Notchless homolog 1
          Length = 484

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 53/184 (28%), Positives = 85/184 (46%), Gaps = 1/184 (0%)
 Frame = +2

Query: 20  HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
           H  +V S+ +SP   G  LA GS D ++     L    P +      H   + S+ W+P 
Sbjct: 112 HSEAVISVAFSPT--GKYLASGSGDTTVRFWD-LSTETPHF--TCKGHRHWVLSISWSP- 165

Query: 200 TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
                 +G    K+L SG  +G++ +W  + G+ V  T L GHS W+  ++W P+ ++ E
Sbjct: 166 ------DG----KKLASGCKNGQILLWDPSTGKQVGRT-LAGHSKWITGLSWEPLHANPE 214

Query: 380 -QIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNI 556
            + +AS  + G V IW  +A        +  L    Q V  L W   G +L  +S D  I
Sbjct: 215 CRYVASSSKDGSVRIWDTTAGR-----CERILTGHTQSVTCLRWGGDG-LLYSASQDRTI 268

Query: 557 SLWK 568
            +W+
Sbjct: 269 KVWR 272

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 38/166 (22%), Positives = 67/166 (40%)
 Frame = +2

Query: 74  LACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKRLVSG 253
           L  GS D ++ + +   D  P  +     H   IN V ++P + I           + S 
Sbjct: 343 LVSGSDDFTLFLWSPAEDKKPLTRMTG--HQALINQVLFSPDSRI-----------VASA 389

Query: 254 GCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIWTQS 433
             D  +K+W    G+++    LRGH   V  +AW    S++ +++ S      + +W   
Sbjct: 390 SFDKSIKLWDGRTGKYLAS--LRGHVAAVYQIAW----SADSRLLVSGSSDSTLKVWDVK 443

Query: 434 AEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQ 571
           A     Q     LP     V+ + WS  G  +A    D  + +W++
Sbjct: 444 A-----QKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 484

 Score = 33.9 bits (76), Expect = 0.41
 Identities = 25/110 (22%), Positives = 44/110 (40%)
 Frame = +2

Query: 236 KRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHV 415
           +RLVSG  D  + +W     +    T + GH   +  V + P    + +I+AS      +
Sbjct: 341 ERLVSGSDDFTLFLWSPAEDK-KPLTRMTGHQALINQVLFSP----DSRIVASASFDKSI 395

Query: 416 NIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW 565
            +W      G        L      V+ ++WS    +L   S D+ + +W
Sbjct: 396 KLWD-----GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 440
>sp|Q8VEJ4|NLE1_MOUSE Notchless homolog 1
          Length = 485

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 1/184 (0%)
 Frame = +2

Query: 20  HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
           H  +V S+ +SP   G  LA GS D ++     L    P +      H   + S+ W+P 
Sbjct: 113 HSEAVISVAFSPT--GKYLASGSGDTTVRFWD-LSTETPHF--TCKGHRHWVLSISWSP- 166

Query: 200 TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
                 +G    K+L SG  +G++ +W  + G  V  T L GHS W+  ++W P+  + E
Sbjct: 167 ------DG----KKLASGCKNGQILLWDPSTGLQVGRT-LTGHSKWITGLSWEPLHMNPE 215

Query: 380 -QIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNI 556
            + +AS  + G V +W  +A        +  L    Q V  L W   G +L  +S D  I
Sbjct: 216 CRYVASSSKDGSVRVWDTTAGR-----CERILTGHTQSVTCLRWGGDG-LLYSASQDRTI 269

Query: 557 SLWK 568
            +W+
Sbjct: 270 KVWR 273

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 39/166 (23%), Positives = 68/166 (40%)
 Frame = +2

Query: 74  LACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKRLVSG 253
           L  GS D ++ + +   D  P  +     H   IN V ++P + I           + S 
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLARMTG--HQALINQVLFSPDSRI-----------VASA 390

Query: 254 GCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIWTQS 433
             D  +K+W    G+++    LRGH   V  +AW    S++ +++ S      + +W   
Sbjct: 391 SFDKSIKLWDGRTGKYLAS--LRGHVAAVYQIAW----SADSRLLVSGSSDSTLKVWDVK 444

Query: 434 AEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQ 571
           A     Q   T LP     V+ + WS  G  +A    D  + +W++
Sbjct: 445 A-----QKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 24/110 (21%), Positives = 43/110 (39%)
 Frame = +2

Query: 236 KRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHV 415
           +RLVSG  D  + +W     +      + GH   +  V + P    + +I+AS      +
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDK-KPLARMTGHQALINQVLFSP----DSRIVASASFDKSI 396

Query: 416 NIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW 565
            +W      G        L      V+ ++WS    +L   S D+ + +W
Sbjct: 397 KLWD-----GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,992,702
Number of Sequences: 369166
Number of extensions: 2048740
Number of successful extensions: 6692
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5802
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6471
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5830600200
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)