Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02596
(685 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P55735|SEC13_HUMAN SEC13-related protein (SEC13-like pro... 238 1e-62
sp|Q9D1M0|SEC13_MOUSE SEC13-related protein (SEC13-like pro... 236 4e-62
sp|Q04491|SEC13_YEAST Protein transport protein SEC13 179 5e-45
sp|P53024|SEC13_PICPA Protein transport protein SEC13 164 2e-40
sp|Q10099|SEH1_SCHPO Nuclear pore protein SEH1 homolog 68 2e-11
sp|Q00808|HETE1_PODAN Vegetatible incompatibility protein H... 61 2e-09
sp|O76071|WDR39_HUMAN WD-repeat protein 39 (Ciao 1 protein) 61 2e-09
sp|Q9NVX2|NLE1_HUMAN Notchless homolog 1 61 2e-09
sp|Q5RFF8|NLE1_PONPY Notchless homolog 1 61 2e-09
sp|Q8VEJ4|NLE1_MOUSE Notchless homolog 1 59 2e-08
>sp|P55735|SEC13_HUMAN SEC13-related protein (SEC13-like protein 1)
Length = 322
Score = 238 bits (606), Expect = 1e-62
Identities = 112/215 (52%), Positives = 147/215 (68%), Gaps = 7/215 (3%)
Frame = +2
Query: 8 EYCNHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVW 187
E+ HDSSVNS+CW+P +YG +LACGSSDG++S++T G+G + KK+++AH IG N+V
Sbjct: 98 EHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVS 157
Query: 188 WAPA----TFIEDAEGEK--VIKRLVSGGCDGEVKIWK-ETGGRWVEETVLRGHSDWVRD 346
WAPA + I+ G+K IKR SGGCD +K+WK E G+W EE L HSDWVRD
Sbjct: 158 WAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRD 217
Query: 347 VAWCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDI 526
VAW P IASC Q G V IWT + +N W L F VVWH+SWS+T +I
Sbjct: 218 VAWAPSIGLPTSTIASCSQDGRVFIWT-CDDASSNTWSPKLLHKFNDVVWHVSWSITANI 276
Query: 527 LAVSSGDNNISLWKQNLEGQWACISAVNQGEGDIS 631
LAVS GDN ++LWK++++GQW CIS VN+G+G +S
Sbjct: 277 LAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311
Score = 48.5 bits (114), Expect = 2e-05
Identities = 46/142 (32%), Positives = 60/142 (42%), Gaps = 3/142 (2%)
Frame = +2
Query: 173 INSVWWAPATFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVA 352
IN+V + I DA+ + RL + D VKI+ G + LRGH V VA
Sbjct: 5 INTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64
Query: 353 WCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPV-FPQVVWHLSWSV--TGD 523
W N I+ASC V IW + N W+++ V + W+ G
Sbjct: 65 WAHPMYGN--ILASCSYDRKVIIWREE----NGTWEKSHEHAGHDSSVNSVCWAPHDYGL 118
Query: 524 ILAVSSGDNNISLWKQNLEGQW 589
ILA S D ISL EGQW
Sbjct: 119 ILACGSSDGAISLLTYTGEGQW 140
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/194 (26%), Positives = 74/194 (38%), Gaps = 18/194 (9%)
Frame = +2
Query: 62 YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
YG LA SSD S+ I + G + H + V WA +
Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQILIADLR-GHEGPVWQVAWAHPMYGNI--------- 73
Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNI 421
L S D +V IW+E G W + GH V V W P I+A G +++
Sbjct: 74 LASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP--HDYGLILACGSSDGAISL 131
Query: 422 WTQSAEHGNNQWQQTCLPVFPQVVWH-LSWS---VTGDILAVSSG--------------D 547
T + G QW+ + + + +SW+ V G ++ SG D
Sbjct: 132 LTYT---GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCD 188
Query: 548 NNISLWKQNLEGQW 589
N I LWK+ +GQW
Sbjct: 189 NLIKLWKEEEDGQW 202
>sp|Q9D1M0|SEC13_MOUSE SEC13-related protein (SEC13-like protein 1)
Length = 322
Score = 236 bits (602), Expect = 4e-62
Identities = 111/215 (51%), Positives = 146/215 (67%), Gaps = 7/215 (3%)
Frame = +2
Query: 8 EYCNHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVW 187
E+ HDSSVNS+CW+P +YG +LACGSSDG++S++T G+G + KK+++AH IG N+V
Sbjct: 98 EHSGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVS 157
Query: 188 WAPA----TFIEDAEGEK--VIKRLVSGGCDGEVKIWK-ETGGRWVEETVLRGHSDWVRD 346
WAPA + I+ G+K IK+ SGGCD +K+W+ E G+W EE L HSDWVRD
Sbjct: 158 WAPAVVPGSLIDQPSGQKPNYIKKFASGGCDNLIKLWREEEDGQWKEEQKLEAHSDWVRD 217
Query: 347 VAWCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDI 526
VAW P IASC Q G V IWT G N W L F VVWH+SWS+T +I
Sbjct: 218 VAWAPSIGLPTSTIASCSQDGRVFIWTCDDASG-NMWSPKLLHKFNDVVWHVSWSITANI 276
Query: 527 LAVSSGDNNISLWKQNLEGQWACISAVNQGEGDIS 631
LAVS GDN ++LWK++++GQW CIS VN+G+G +S
Sbjct: 277 LAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVS 311
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/194 (26%), Positives = 74/194 (38%), Gaps = 18/194 (9%)
Frame = +2
Query: 62 YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
YG LA SSD S+ I + G + H + V WA +
Sbjct: 24 YGTRLATCSSDRSVKIFDVRNGGQILIADLR-GHEGPVWQVAWAHPMYGNI--------- 73
Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNI 421
L S D +V IWKE G W + GH V V W P I+A G +++
Sbjct: 74 LASCSYDRKVIIWKEENGTWEKTHEHSGHDSSVNSVCWAP--HDYGLILACGSSDGAISL 131
Query: 422 WTQSAEHGNNQWQQTCLPVFPQVVWH-LSWS---VTGDILAVSSG--------------D 547
T + G QW+ + + + +SW+ V G ++ SG D
Sbjct: 132 LTYT---GEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDQPSGQKPNYIKKFASGGCD 188
Query: 548 NNISLWKQNLEGQW 589
N I LW++ +GQW
Sbjct: 189 NLIKLWREEEDGQW 202
Score = 48.1 bits (113), Expect = 2e-05
Identities = 46/142 (32%), Positives = 60/142 (42%), Gaps = 3/142 (2%)
Frame = +2
Query: 173 INSVWWAPATFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVA 352
+N+V + I DA+ + RL + D VKI+ G + LRGH V VA
Sbjct: 5 MNTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVA 64
Query: 353 WCPITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTC-LPVFPQVVWHLSWSV--TGD 523
W N I+ASC V IW + N W++T V + W+ G
Sbjct: 65 WAHPMYGN--ILASCSYDRKVIIWKEE----NGTWEKTHEHSGHDSSVNSVCWAPHDYGL 118
Query: 524 ILAVSSGDNNISLWKQNLEGQW 589
ILA S D ISL EGQW
Sbjct: 119 ILACGSSDGAISLLTYTGEGQW 140
>sp|Q04491|SEC13_YEAST Protein transport protein SEC13
Length = 297
Score = 179 bits (455), Expect = 5e-45
Identities = 96/204 (47%), Positives = 125/204 (61%), Gaps = 6/204 (2%)
Frame = +2
Query: 20 HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
H +SVNS+ W+P EYGP+L SSDG +S++ +G + DAH IG+NS WAPA
Sbjct: 98 HSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFKENGTTS-PIIIDAHAIGVNSASWAPA 156
Query: 200 TFIEDAE--GEKVIKRLVSGGCDGEVKIWKETGGR--WVEETVLRGHSDWVRDVAWCPIT 367
T ED E G K ++ V+GG D VKIWK +V E+ L GHSDWVRDVAW P T
Sbjct: 157 TIEEDGEHNGTKESRKFVTGGADNLVKIWKYNSDAQTYVLESTLEGHSDWVRDVAWSP-T 215
Query: 368 SSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPV--FPQVVWHLSWSVTGDILAVSS 541
+AS Q IWTQ E G W++T L FP V+W SWS++G++LA+S
Sbjct: 216 VLLRSYLASVSQDRTCIIWTQDNEQG--PWKKTLLKEEKFPDVLWRASWSLSGNVLALSG 273
Query: 542 GDNNISLWKQNLEGQWACISAVNQ 613
GDN ++LWK+NLEG+W V+Q
Sbjct: 274 GDNKVTLWKENLEGKWEPAGEVHQ 297
Score = 48.5 bits (114), Expect = 2e-05
Identities = 52/201 (25%), Positives = 74/201 (36%), Gaps = 13/201 (6%)
Frame = +2
Query: 62 YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
YG LA SSD ++ I + G+ + K+ D VW D K
Sbjct: 20 YGKRLATCSSDKTIKIFEVEGETH----KLIDTLTGHEGPVWRV------DWAHPKFGTI 69
Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNI 421
L S DG+V IWKE GRW + V HS V V W P ++AS D G V++
Sbjct: 70 LASCSYDGKVLIWKEENGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSD--GKVSV 127
Query: 422 WTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVT-------------GDILAVSSGDNNISL 562
+ E+G + V SW+ DN + +
Sbjct: 128 -VEFKENGTT--SPIIIDAHAIGVNSASWAPATIEEDGEHNGTKESRKFVTGGADNLVKI 184
Query: 563 WKQNLEGQWACISAVNQGEGD 625
WK N + Q + + +G D
Sbjct: 185 WKYNSDAQTYVLESTLEGHSD 205
Score = 38.9 bits (89), Expect = 0.013
Identities = 38/128 (29%), Positives = 55/128 (42%), Gaps = 5/128 (3%)
Frame = +2
Query: 206 IEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQI 385
I DA + KRL + D +KI++ G L GH V V W I
Sbjct: 12 IHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT--I 69
Query: 386 IASCDQTGHVNIWTQSAEHGNNQWQQTCL-PVFPQVVWHLSWS--VTGDILAVSSGDNNI 556
+ASC G V IW + N +W Q + V V + W+ G +L V+S D +
Sbjct: 70 LASCSYDGKVLIWKEE----NGRWSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKV 125
Query: 557 SL--WKQN 574
S+ +K+N
Sbjct: 126 SVVEFKEN 133
>sp|P53024|SEC13_PICPA Protein transport protein SEC13
Length = 289
Score = 164 bits (416), Expect = 2e-40
Identities = 87/206 (42%), Positives = 124/206 (60%), Gaps = 4/206 (1%)
Frame = +2
Query: 8 EYCNHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVW 187
E+ H +SVNS+ W+P EYGP+L C SSDG +SI+ DG V H IG N+
Sbjct: 94 EHSVHQASVNSVSWAPHEYGPVLLCASSDGKISIVEFK-DGGALEPIVIQGHAIGGNAAS 152
Query: 188 WAPATFIEDAEGEKVIKRLVSGGCDGEVKIWK--ETGGRWVEETVLRGHSDWVRDVAWCP 361
WAP + ++ +R VSGGCD VKIW+ + ++EE +GHSDWVRDVAW P
Sbjct: 153 WAPISLPDNT------RRFVSGGCDNLVKIWRYDDAAKTFIEEEAFQGHSDWVRDVAWSP 206
Query: 362 ITSSNEQIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPV--FPQVVWHLSWSVTGDILAV 535
S + IA+ Q V IWT+ + +N+W++ L FP V W SWS++G++LA+
Sbjct: 207 SRLS-KSYIATASQDRTVLIWTKDGK--SNKWEKQPLTKEKFPDVCWRASWSLSGNVLAI 263
Query: 536 SSGDNNISLWKQNLEGQWACISAVNQ 613
S GDN ++L K+N++G+W V+Q
Sbjct: 264 SGGDNKVTLSKENIQGKWESAGEVDQ 289
Score = 40.0 bits (92), Expect = 0.006
Identities = 37/113 (32%), Positives = 46/113 (40%)
Frame = +2
Query: 62 YGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKR 241
YG LA SSD ++ I I G+ N + H + V WA F VI
Sbjct: 20 YGRRLATCSSDKTIKIFEIDGE-NQRLVETLIGHEGPVWQVAWAHPKF-------GVI-- 69
Query: 242 LVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCD 400
L S DG+V IWKE G W + H V V+W P + AS D
Sbjct: 70 LASCSYDGKVLIWKEDNGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSD 122
Score = 35.8 bits (81), Expect = 0.11
Identities = 36/122 (29%), Positives = 50/122 (40%), Gaps = 3/122 (2%)
Frame = +2
Query: 206 IEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQI 385
I DA + +RL + D +KI++ G L GH V VAW I
Sbjct: 12 IHDAVLDYYGRRLATCSSDKTIKIFEIDGENQRLVETLIGHEGPVWQVAWA--HPKFGVI 69
Query: 386 IASCDQTGHVNIWTQSAEHGNNQWQQTC-LPVFPQVVWHLSWS--VTGDILAVSSGDNNI 556
+ASC G V IW + N W + V V +SW+ G +L +S D I
Sbjct: 70 LASCSYDGKVLIWKED----NGVWNKVAEHSVHQASVNSVSWAPHEYGPVLLCASSDGKI 125
Query: 557 SL 562
S+
Sbjct: 126 SI 127
>sp|Q10099|SEH1_SCHPO Nuclear pore protein SEH1 homolog
Length = 339
Score = 68.2 bits (165), Expect = 2e-11
Identities = 55/229 (24%), Positives = 99/229 (43%), Gaps = 34/229 (14%)
Frame = +2
Query: 26 SSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINS-------- 181
S+V I + P ++G LA S+D ++ I + GN Y + + + +
Sbjct: 112 SAVLDISFCPFQHGCKLAAVSADATLRIYEAMEPGNLTYWTLMNEIALMPSPPSRNEQPA 171
Query: 182 --VWWAPATFIEDAEGEKVIKRLVSGGCDGEVKIWKETG-GRWVEETVLRGHSDWVRDVA 352
V W P+ + E + ++ GC + I+K+ G+W + L GH+D +RD+
Sbjct: 172 FCVNWCPSRWRE---------QYIAVGCMNDAYIYKQNSHGKWKKVAELPGHTDLIRDIC 222
Query: 353 WCPITSSNEQIIASCDQTGHVNIWT----------QSAEHGNNQWQQTCLPV-------- 478
W P S+ +IA+ + G+V I+ + + GN+ + + +
Sbjct: 223 WAPSMGSSYYLIATACKDGNVRIFKVETLCEEVFQEEEDAGNSMTEDSNFNLNSLKVELI 282
Query: 479 -----FPQVVWHLSWSVTGDILAVSSGDNNISLWKQNLEGQWACISAVN 610
VW ++VTG IL+ S D + LWK + + CIS V+
Sbjct: 283 GEYDNHKCQVWRCRFNVTGTILSSSGDDGCVRLWKASYANLFKCISVVS 331
Score = 29.6 bits (65), Expect = 7.7
Identities = 46/214 (21%), Positives = 75/214 (35%), Gaps = 23/214 (10%)
Frame = +2
Query: 17 NHDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSD--AHNIGINSVWW 190
NH VN + + YG + S+D + + D + S+ A + + V W
Sbjct: 12 NHQDLVNDVTYD--FYGRRMVSCSADQRVKVYDF-NDDTETWAITSEWRAGDASLMRVAW 68
Query: 191 APATFIEDAEGEKVIKRLVSGGCDGEVKIWKET-----GGRWVEETVLRGHSDWVRDVAW 355
A +F + L D V+I++E WVE L V D+++
Sbjct: 69 AHPSFGQV---------LAVCSLDRGVRIYEEQKKNFESKTWVEVAKLMDARSAVLDISF 119
Query: 356 CPITSSNEQIIASCDQT---------GHVNIWTQSAE-------HGNNQWQQTCLPVFPQ 487
CP + S D T G++ WT E N+ C+ P
Sbjct: 120 CPFQHGCKLAAVSADATLRIYEAMEPGNLTYWTLMNEIALMPSPPSRNEQPAFCVNWCPS 179
Query: 488 VVWHLSWSVTGDILAVSSGDNNISLWKQNLEGQW 589
W + G + N+ ++KQN G+W
Sbjct: 180 -RWREQYIAVGCM-------NDAYIYKQNSHGKW 205
>sp|Q00808|HETE1_PODAN Vegetatible incompatibility protein HET-E-1
Length = 1356
Score = 61.2 bits (147), Expect = 2e-09
Identities = 58/206 (28%), Positives = 88/206 (42%), Gaps = 7/206 (3%)
Frame = +2
Query: 20 HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
H SV S+ +SP G +A GS DG+ I I + + + H ++SV ++P
Sbjct: 1092 HGDSVWSVAFSPD--GQRVASGSIDGT---IKIWDAASGTCTQTLEGHGGWVHSVAFSP- 1145
Query: 200 TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
+G++V SG DG +KIW G + L GH WV+ VA+ P +
Sbjct: 1146 ------DGQRV----ASGSIDGTIKIWDAASGTCTQ--TLEGHGGWVQSVAFSP----DG 1189
Query: 380 QIIASCDQTGHVNIW-------TQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVS 538
Q +AS + IW TQ+ E G+ W Q+ +++S G +A
Sbjct: 1190 QRVASGSSDKTIKIWDTASGTCTQTLE-GHGGWVQS-----------VAFSPDGQRVASG 1237
Query: 539 SGDNNISLWKQNLEGQWACISAVNQG 616
S DN I +W C +N G
Sbjct: 1238 SSDNTIKIWD---TASGTCTQTLNVG 1260
Score = 51.6 bits (122), Expect = 2e-06
Identities = 65/238 (27%), Positives = 97/238 (40%), Gaps = 42/238 (17%)
Frame = +2
Query: 20 HDSSVNSICWSPPEYGPMLACGSSDGSMSII---------TILGDG--------NPDYKK 148
H SSV S+ +SP G +A GS D ++ I T+ G G +PD ++
Sbjct: 966 HGSSVLSVAFSPD--GQRVASGSGDKTIKIWDTASGTCTQTLEGHGGSVWSVAFSPDGQR 1023
Query: 149 VSDAHNIGINSVW-WAPATFIEDAEG-----EKVI-----KRLVSGGCDGEVKIWKETGG 295
V+ + +W A T + EG + V+ +R+ SG D +KIW G
Sbjct: 1024 VASGSDDKTIKIWDTASGTCTQTLEGHGGWVQSVVFSPDGQRVASGSDDHTIKIWDAVSG 1083
Query: 296 RWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIW-------TQSAEHGNNQ 454
+ L GH D V VA+ P + Q +AS G + IW TQ+ E G+
Sbjct: 1084 TCTQ--TLEGHGDSVWSVAFSP----DGQRVASGSIDGTIKIWDAASGTCTQTLE-GHGG 1136
Query: 455 WQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW-------KQNLEGQWACISAV 607
W V +++S G +A S D I +W Q LEG + +V
Sbjct: 1137 W-----------VHSVAFSPDGQRVASGSIDGTIKIWDAASGTCTQTLEGHGGWVQSV 1183
Score = 37.7 bits (86), Expect = 0.028
Identities = 42/170 (24%), Positives = 64/170 (37%), Gaps = 23/170 (13%)
Frame = +2
Query: 167 IGINSVWWAPATFIEDAEGEKVI--------KRLVSGGCDGEVKIWKETGGRWVEETVLR 322
I + W T + G V+ +R+ SG D +KIW G + L
Sbjct: 823 ISVVEAEWNACTQTLEGHGSSVLSVAFSADGQRVASGSDDKTIKIWDTASGTGTQ--TLE 880
Query: 323 GHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIW-------TQSAE-HGNNQWQQTCLPV 478
GH V VA+ P + + +AS + IW TQ+ E HG
Sbjct: 881 GHGGSVWSVAFSP----DRERVASGSDDKTIKIWDAASGTCTQTLEGHGGR--------- 927
Query: 479 FPQVVWHLSWSVTGDILAVSSGDNNISLW-------KQNLEGQWACISAV 607
V +++S G +A S D+ I +W Q LEG + + +V
Sbjct: 928 ----VQSVAFSPDGQRVASGSDDHTIKIWDAASGTCTQTLEGHGSSVLSV 973
>sp|O76071|WDR39_HUMAN WD-repeat protein 39 (Ciao 1 protein)
Length = 339
Score = 61.2 bits (147), Expect = 2e-09
Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 1/133 (0%)
Frame = +2
Query: 242 LVSGGCDGEVKIWKETGGRWVEETVL-RGHSDWVRDVAWCPITSSNEQIIASCDQTGHVN 418
L S G D ++IW G W+ ++VL GH VR VAW P N AS D T
Sbjct: 31 LASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC--GNYLASASFDAT--TC 86
Query: 419 IWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQNLEGQWACI 598
IW ++ + T L V ++W+ +G++LA S D ++ +W+ + E ++ C+
Sbjct: 87 IWKKNQDDFECV---TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
Query: 599 SAVNQGEGDISNI 637
S +N D+ ++
Sbjct: 144 SVLNSHTQDVKHV 156
Score = 50.4 bits (119), Expect = 4e-06
Identities = 55/250 (22%), Positives = 84/250 (33%), Gaps = 54/250 (21%)
Frame = +2
Query: 23 DSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPAT 202
DS + W+P G +LA D + I GD +S+ H + V W+P
Sbjct: 16 DSRCWFLAWNPA--GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG 73
Query: 203 FIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQ 382
L S D IWK+ + T L GH + V+ VAW P +
Sbjct: 74 -----------NYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP----SGN 118
Query: 383 IIASCDQTGHVNIW-----------------TQSAEH----------GNNQWQQTC---- 469
++A+C + V +W TQ +H + + T
Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
Query: 470 -----------LPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQNLEG----------- 583
L VW L++ +G LA S D + +W+Q L G
Sbjct: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSD 238
Query: 584 -QWACISAVN 610
W CI ++
Sbjct: 239 PSWKCICTLS 248
Score = 35.4 bits (80), Expect = 0.14
Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
Frame = +2
Query: 494 WHLSWSVTGDILAVSSGDNNISLWKQNLEG-QWACISAVNQG 616
W L+W+ G +LA GD I +W EG W C S +++G
Sbjct: 20 WFLAWNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEG 59
Score = 34.7 bits (78), Expect = 0.24
Identities = 54/248 (21%), Positives = 91/248 (36%), Gaps = 60/248 (24%)
Frame = +2
Query: 20 HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
H++ V S+ W+P G +LA S D S+ + + + + V ++H + V W P+
Sbjct: 104 HENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPS 161
Query: 200 T-FIEDAEGEKVIK--------------------------------RLVSGGCDGEVKIW 280
+ A + +K RL S D V+IW
Sbjct: 162 QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Query: 281 KE-------------TGGRWVEETVLRG-HSDWVRDVAWCPITSSNEQIIASCDQTGHVN 418
++ + W L G HS + D+AWC +T + +A+ +
Sbjct: 222 RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA----LATACGDDAIR 277
Query: 419 IWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDI------------LAVSSGDNNISL 562
++ E N+ QQ P F + HL + + D+ LA S D ++
Sbjct: 278 VF---QEDPNSDPQQ---PTF-SLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAF 330
Query: 563 WK-QNLEG 583
WK Q EG
Sbjct: 331 WKYQRPEG 338
>sp|Q9NVX2|NLE1_HUMAN Notchless homolog 1
Length = 485
Score = 61.2 bits (147), Expect = 2e-09
Identities = 53/184 (28%), Positives = 85/184 (46%), Gaps = 1/184 (0%)
Frame = +2
Query: 20 HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
H +V S+ +SP G LA GS D ++ L P + H + S+ W+P
Sbjct: 113 HSEAVISVAFSPT--GKYLASGSGDTTVRFWD-LSTETPHF--TCKGHRHWVLSISWSP- 166
Query: 200 TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
+G K+L SG +G++ +W + G+ V T L GHS W+ ++W P+ ++ E
Sbjct: 167 ------DG----KKLASGCKNGQILLWDPSTGKQVGRT-LAGHSKWITGLSWEPLHANPE 215
Query: 380 -QIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNI 556
+ +AS + G V IW +A + L Q V L W G +L +S D I
Sbjct: 216 CRYVASSSKDGSVRIWDTTAGR-----CERILTGHTQSVTCLRWGGDG-LLYSASQDRTI 269
Query: 557 SLWK 568
+W+
Sbjct: 270 KVWR 273
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/166 (22%), Positives = 67/166 (40%)
Frame = +2
Query: 74 LACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKRLVSG 253
L GS D ++ + + D P + H IN V ++P + I + S
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTG--HQALINQVLFSPDSRI-----------VASA 390
Query: 254 GCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIWTQS 433
D +K+W G+++ LRGH V +AW S++ +++ S + +W
Sbjct: 391 SFDKSIKLWDGRTGKYLAS--LRGHVAAVYQIAW----SADSRLLVSGSSDSTLKVWDVK 444
Query: 434 AEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQ 571
A Q LP V+ + WS G +A D + +W++
Sbjct: 445 A-----QKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Score = 33.9 bits (76), Expect = 0.41
Identities = 25/110 (22%), Positives = 44/110 (40%)
Frame = +2
Query: 236 KRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHV 415
+RLVSG D + +W + T + GH + V + P + +I+AS +
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDK-KPLTRMTGHQALINQVLFSP----DSRIVASASFDKSI 396
Query: 416 NIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW 565
+W G L V+ ++WS +L S D+ + +W
Sbjct: 397 KLWD-----GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
>sp|Q5RFF8|NLE1_PONPY Notchless homolog 1
Length = 484
Score = 61.2 bits (147), Expect = 2e-09
Identities = 53/184 (28%), Positives = 85/184 (46%), Gaps = 1/184 (0%)
Frame = +2
Query: 20 HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
H +V S+ +SP G LA GS D ++ L P + H + S+ W+P
Sbjct: 112 HSEAVISVAFSPT--GKYLASGSGDTTVRFWD-LSTETPHF--TCKGHRHWVLSISWSP- 165
Query: 200 TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
+G K+L SG +G++ +W + G+ V T L GHS W+ ++W P+ ++ E
Sbjct: 166 ------DG----KKLASGCKNGQILLWDPSTGKQVGRT-LAGHSKWITGLSWEPLHANPE 214
Query: 380 -QIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNI 556
+ +AS + G V IW +A + L Q V L W G +L +S D I
Sbjct: 215 CRYVASSSKDGSVRIWDTTAGR-----CERILTGHTQSVTCLRWGGDG-LLYSASQDRTI 268
Query: 557 SLWK 568
+W+
Sbjct: 269 KVWR 272
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/166 (22%), Positives = 67/166 (40%)
Frame = +2
Query: 74 LACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKRLVSG 253
L GS D ++ + + D P + H IN V ++P + I + S
Sbjct: 343 LVSGSDDFTLFLWSPAEDKKPLTRMTG--HQALINQVLFSPDSRI-----------VASA 389
Query: 254 GCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIWTQS 433
D +K+W G+++ LRGH V +AW S++ +++ S + +W
Sbjct: 390 SFDKSIKLWDGRTGKYLAS--LRGHVAAVYQIAW----SADSRLLVSGSSDSTLKVWDVK 443
Query: 434 AEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQ 571
A Q LP V+ + WS G +A D + +W++
Sbjct: 444 A-----QKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 484
Score = 33.9 bits (76), Expect = 0.41
Identities = 25/110 (22%), Positives = 44/110 (40%)
Frame = +2
Query: 236 KRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHV 415
+RLVSG D + +W + T + GH + V + P + +I+AS +
Sbjct: 341 ERLVSGSDDFTLFLWSPAEDK-KPLTRMTGHQALINQVLFSP----DSRIVASASFDKSI 395
Query: 416 NIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW 565
+W G L V+ ++WS +L S D+ + +W
Sbjct: 396 KLWD-----GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 440
>sp|Q8VEJ4|NLE1_MOUSE Notchless homolog 1
Length = 485
Score = 58.5 bits (140), Expect = 2e-08
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 1/184 (0%)
Frame = +2
Query: 20 HDSSVNSICWSPPEYGPMLACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPA 199
H +V S+ +SP G LA GS D ++ L P + H + S+ W+P
Sbjct: 113 HSEAVISVAFSPT--GKYLASGSGDTTVRFWD-LSTETPHF--TCKGHRHWVLSISWSP- 166
Query: 200 TFIEDAEGEKVIKRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNE 379
+G K+L SG +G++ +W + G V T L GHS W+ ++W P+ + E
Sbjct: 167 ------DG----KKLASGCKNGQILLWDPSTGLQVGRT-LTGHSKWITGLSWEPLHMNPE 215
Query: 380 -QIIASCDQTGHVNIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNI 556
+ +AS + G V +W +A + L Q V L W G +L +S D I
Sbjct: 216 CRYVASSSKDGSVRVWDTTAGR-----CERILTGHTQSVTCLRWGGDG-LLYSASQDRTI 269
Query: 557 SLWK 568
+W+
Sbjct: 270 KVWR 273
Score = 43.5 bits (101), Expect = 5e-04
Identities = 39/166 (23%), Positives = 68/166 (40%)
Frame = +2
Query: 74 LACGSSDGSMSIITILGDGNPDYKKVSDAHNIGINSVWWAPATFIEDAEGEKVIKRLVSG 253
L GS D ++ + + D P + H IN V ++P + I + S
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLARMTG--HQALINQVLFSPDSRI-----------VASA 390
Query: 254 GCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHVNIWTQS 433
D +K+W G+++ LRGH V +AW S++ +++ S + +W
Sbjct: 391 SFDKSIKLWDGRTGKYLAS--LRGHVAAVYQIAW----SADSRLLVSGSSDSTLKVWDVK 444
Query: 434 AEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLWKQ 571
A Q T LP V+ + WS G +A D + +W++
Sbjct: 445 A-----QKLATDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Score = 32.0 bits (71), Expect = 1.6
Identities = 24/110 (21%), Positives = 43/110 (39%)
Frame = +2
Query: 236 KRLVSGGCDGEVKIWKETGGRWVEETVLRGHSDWVRDVAWCPITSSNEQIIASCDQTGHV 415
+RLVSG D + +W + + GH + V + P + +I+AS +
Sbjct: 342 ERLVSGSDDFTLFLWSPAEDK-KPLARMTGHQALINQVLFSP----DSRIVASASFDKSI 396
Query: 416 NIWTQSAEHGNNQWQQTCLPVFPQVVWHLSWSVTGDILAVSSGDNNISLW 565
+W G L V+ ++WS +L S D+ + +W
Sbjct: 397 KLWD-----GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,992,702
Number of Sequences: 369166
Number of extensions: 2048740
Number of successful extensions: 6692
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5802
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6471
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5830600200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)