Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02514
(821 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P58750|PIM3_MOUSE Serine/threonine-protein kinase Pim-3 171 2e-42
sp|O70444|PIM3_RAT Serine/threonine-protein kinase Pim-3 (P... 171 2e-42
sp|Q9PU85|PIM3_COTJA Serine/threonine-protein kinase Pim-3 ... 170 5e-42
sp|P06803|PIM1_MOUSE Proto-oncogene serine/threonine-protei... 169 8e-42
sp|Q9YHZ5|PIM1_BRARE Serine/threonine-protein kinase Pim-1 168 1e-41
sp|Q86V86|PIM3_HUMAN Serine/threonine-protein kinase Pim-3 168 2e-41
sp|P11309|PIM1_HUMAN Proto-oncogene serine/threonine-protei... 167 3e-41
sp|P26794|PIM1_RAT Proto-oncogene serine/threonine-protein ... 166 5e-41
sp|Q9N0P9|PIM1_BOVIN Proto-oncogene serine/threonine-protei... 166 9e-41
sp|Q95LJ0|PIM1_FELCA Proto-oncogene serine/threonine-protei... 166 9e-41
>sp|P58750|PIM3_MOUSE Serine/threonine-protein kinase Pim-3
Length = 326
Score = 171 bits (433), Expect = 2e-42
Identities = 74/144 (51%), Positives = 102/144 (70%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CHN GV HRDIKDEN+++DL + ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 160 HCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRYH 219
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLG+LLYDMVCG++P++ D+ I+ L FRR +S CQ LI CL P
Sbjct: 220 RYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPS 279
Query: 455 KRPTLSDILKHRWFKSFHSELPKS 384
+RP+L I H W +P++
Sbjct: 280 ERPSLDQIAAHPWMLGTEGSVPEN 303
>sp|O70444|PIM3_RAT Serine/threonine-protein kinase Pim-3 (Protein kinase Kid-1)
(Kinase induced by depolarization)
Length = 326
Score = 171 bits (433), Expect = 2e-42
Identities = 74/144 (51%), Positives = 102/144 (70%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CHN GV HRDIKDEN+++DL + ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 160 HCHNCGVVHRDIKDENLLVDLRSGELKLIDFGSGAVLKDTVYTDFDGTRVYSPPEWIRYH 219
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLG+LLYDMVCG++P++ D+ I+ L FRR +S CQ LI CL P
Sbjct: 220 RYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLFFRRRVSPECQQLIEWCLSLRPS 279
Query: 455 KRPTLSDILKHRWFKSFHSELPKS 384
+RP+L I H W +P++
Sbjct: 280 ERPSLDQIAAHPWMLGTEGSVPEN 303
>sp|Q9PU85|PIM3_COTJA Serine/threonine-protein kinase Pim-3 (qpim)
Length = 323
Score = 170 bits (430), Expect = 5e-42
Identities = 78/145 (53%), Positives = 103/145 (71%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+C+ GV HRDIKDEN+++DL T ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 158 HCYGCGVVHRDIKDENLLVDLRTGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 217
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLG+LLYDMVCG++P++ D+ I+ L FRR IS CQ LI CL P
Sbjct: 218 RYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLYFRRRISPECQQLIKWCLSLRPS 277
Query: 455 KRPTLSDILKHRWFKSFHSELPKSQ 381
RPTL I H+W SE+ KS+
Sbjct: 278 DRPTLEQIFDHQWMHK--SEVVKSE 300
>sp|P06803|PIM1_MOUSE Proto-oncogene serine/threonine-protein kinase Pim-1
Length = 313
Score = 169 bits (428), Expect = 8e-42
Identities = 77/147 (52%), Positives = 105/147 (71%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CHN GV HRDIKDENI+IDL+ +I LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 157 HCHNCGVLHRDIKDENILIDLSRGEIKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLGILLYDMVCG++P+++D+ I+ + FR+ +S CQ LI CL P
Sbjct: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQVFFRQTVSSECQHLIKWCLSLRPS 276
Query: 455 KRPTLSDILKHRWFKSFHSELPKSQSQ 375
RP+ +I H W + LP++ S+
Sbjct: 277 DRPSFEEIRNHPWMQG--DLLPQAASE 301
>sp|Q9YHZ5|PIM1_BRARE Serine/threonine-protein kinase Pim-1
Length = 310
Score = 168 bits (426), Expect = 1e-41
Identities = 74/132 (56%), Positives = 95/132 (71%)
Frame = -1
Query: 812 CHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCKK 633
CH+ G+ HRDIKDENI++D T I +IDFG+G L D +Y++F+GTRVYSPPEWI K
Sbjct: 158 CHSKGIVHRDIKDENILVDTRTGDIKVIDFGSGATLKDSMYTDFEGTRVYSPPEWILYHK 217
Query: 632 YHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQK 453
YHA+ L +WSLG+LLYDMVCG++P++ D IV SF + IS C+ LI CL NP
Sbjct: 218 YHALPLTVWSLGVLLYDMVCGDIPFEQDTDIVKAKPSFNKRISNDCRSLICSCLSYNPGD 277
Query: 452 RPTLSDILKHRW 417
RP+L IL+H W
Sbjct: 278 RPSLEQILQHPW 289
>sp|Q86V86|PIM3_HUMAN Serine/threonine-protein kinase Pim-3
Length = 326
Score = 168 bits (425), Expect = 2e-41
Identities = 74/144 (51%), Positives = 101/144 (70%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CH+ GV HRDIKDEN+++DL + ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 160 HCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 219
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLG+LLYDMVCG++P++ D+ I+ L FRR +S CQ LI CL P
Sbjct: 220 RYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPS 279
Query: 455 KRPTLSDILKHRWFKSFHSELPKS 384
+RP+L I H W P+S
Sbjct: 280 ERPSLDQIAAHPWMLGADGGAPES 303
>sp|P11309|PIM1_HUMAN Proto-oncogene serine/threonine-protein kinase Pim-1
Length = 313
Score = 167 bits (423), Expect = 3e-41
Identities = 74/135 (54%), Positives = 98/135 (72%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CHN GV HRDIKDENI+IDL ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLGILLYDMVCG++P+++D+ I+ + FR+ +S CQ LI CL P
Sbjct: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPS 276
Query: 455 KRPTLSDILKHRWFK 411
RPT +I H W +
Sbjct: 277 DRPTFEEIQNHPWMQ 291
>sp|P26794|PIM1_RAT Proto-oncogene serine/threonine-protein kinase Pim-1
Length = 313
Score = 166 bits (421), Expect = 5e-41
Identities = 74/135 (54%), Positives = 98/135 (72%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CHN GV HRDIKDENI+IDL ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLGILLYDMVCG++P+++D+ IV + FR+ +S CQ LI CL P
Sbjct: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIVKGQVYFRQRVSSECQHLIRWCLSLRPS 276
Query: 455 KRPTLSDILKHRWFK 411
RP+ +I H W +
Sbjct: 277 DRPSFEEIQNHPWMQ 291
>sp|Q9N0P9|PIM1_BOVIN Proto-oncogene serine/threonine-protein kinase pim-1
Length = 313
Score = 166 bits (419), Expect = 9e-41
Identities = 74/135 (54%), Positives = 98/135 (72%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CH+ GV HRDIKDENI+IDL ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 157 HCHDCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLGILLYDMVCG++P+++D+ IV + FR+ +S CQ LI CL P
Sbjct: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIVRGQVFFRQRVSSECQHLIRWCLALRPS 276
Query: 455 KRPTLSDILKHRWFK 411
RPT +I H W +
Sbjct: 277 DRPTFEEIQNHPWMQ 291
>sp|Q95LJ0|PIM1_FELCA Proto-oncogene serine/threonine-protein kinase pim-1
Length = 313
Score = 166 bits (419), Expect = 9e-41
Identities = 73/135 (54%), Positives = 98/135 (72%)
Frame = -1
Query: 815 NCHNLGVCHRDIKDENIIIDLATKKIYLIDFGAGGILHDGLYSEFDGTRVYSPPEWIQCK 636
+CHN GV HRDIKDENI+IDL ++ LIDFG+G +L D +Y++FDGTRVYSPPEWI+
Sbjct: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216
Query: 635 KYHAISLEIWSLGILLYDMVCGNLPYDNDDSIVNCCLSFRRPISRICQDLITKCLEKNPQ 456
+YH S +WSLGILLYDMVCG++P+++D+ I+ + FR+ +S CQ LI CL P
Sbjct: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPS 276
Query: 455 KRPTLSDILKHRWFK 411
RP+ +I H W +
Sbjct: 277 DRPSFEEIQNHPWMQ 291
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,333,185
Number of Sequences: 369166
Number of extensions: 1905420
Number of successful extensions: 8365
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6449
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7109
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)