Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02453
(619 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 92 1e-18
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 91 2e-18
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 91 2e-18
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 89 9e-18
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 89 9e-18
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 87 3e-17
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 86 8e-17
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 84 3e-16
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 79 7e-15
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 79 1e-14
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 91.7 bits (226), Expect = 1e-18
Identities = 47/128 (36%), Positives = 76/128 (59%), Gaps = 1/128 (0%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
+FS FYT + GY++C +G G+G+GTHLS+YF +M+GEFD +LQWPF+ V L L+
Sbjct: 428 VFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLL 487
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNAN-LILNNQIF 357
+Q +H +T K PN + +P E G +F+ L + N I ++ +F
Sbjct: 488 DQSGKKNHIVETFK--ADPNSSSFKRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLF 545
Query: 358 IKCSVNIS 381
+K +V+++
Sbjct: 546 LKVAVDLT 553
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 90.9 bits (224), Expect = 2e-18
Identities = 48/133 (36%), Positives = 79/133 (59%), Gaps = 8/133 (6%)
Frame = +1
Query: 4 FSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLIN 183
FS +FYTHK+GYK+ +S +G G+GEGTHLS+Y ++ G FD++L+WPF V SL++
Sbjct: 333 FSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLD 392
Query: 184 Q-QTGL---DHASDT----TKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNANLI 339
Q GL H ++T + +F W ++E GFG +FI +++ N +
Sbjct: 393 QSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDI-RKRNYV 451
Query: 340 LNNQIFIKCSVNI 378
++ +FI+ +V +
Sbjct: 452 RDDAVFIRAAVEL 464
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 90.9 bits (224), Expect = 2e-18
Identities = 48/133 (36%), Positives = 78/133 (58%), Gaps = 8/133 (6%)
Frame = +1
Query: 4 FSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLIN 183
FS +FYTHK+GYK+ +S +G G+GEGTHLS+Y ++ G FD++L+WP V SL++
Sbjct: 333 FSPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLARRVTFSLLD 392
Query: 184 Q-QTGL---DHASDT----TKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNANLI 339
Q GL H ++T + +F W ++E GFG +FI +++ N +
Sbjct: 393 QSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDI-RKRNYV 451
Query: 340 LNNQIFIKCSVNI 378
++ +FI+ SV +
Sbjct: 452 RDDAVFIRASVEL 464
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 89.0 bits (219), Expect = 9e-18
Identities = 51/127 (40%), Positives = 69/127 (54%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
++S FYT GYKMC V +G G G+GTHLS++F +M+GE+D +L WPFK V L L+
Sbjct: 440 LYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLM 499
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNANLILNNQIFI 360
+Q + H D K PN + KP E G F+ L N I ++ IFI
Sbjct: 500 DQGSSRRHLGDAFK--PDPNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFI 556
Query: 361 KCSVNIS 381
K V+ S
Sbjct: 557 KVIVDTS 563
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 89.0 bits (219), Expect = 9e-18
Identities = 51/127 (40%), Positives = 69/127 (54%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
++S FYT GYKMC V +G G G+GTHLS++F +M+GE+D +L WPFK V L L+
Sbjct: 439 LYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLM 498
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNANLILNNQIFI 360
+Q + H D K PN + KP E G F+ L N I ++ IFI
Sbjct: 499 DQGSSRRHLGDAFK--PDPNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFI 555
Query: 361 KCSVNIS 381
K V+ S
Sbjct: 556 KVIVDTS 562
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 87.0 bits (214), Expect = 3e-17
Identities = 48/128 (37%), Positives = 76/128 (59%), Gaps = 1/128 (0%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
IFS SFYT + GY++C +G G+G G+HLS+YF +M+GEFD +LQWPF+ V L L+
Sbjct: 428 IFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLL 487
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNAN-LILNNQIF 357
+ Q+G + +T K PN + +P E G +F+ L N I ++ +F
Sbjct: 488 D-QSGKKNIMETFK--PDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
Query: 358 IKCSVNIS 381
+K +V+++
Sbjct: 545 LKVAVDLT 552
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 85.9 bits (211), Expect = 8e-17
Identities = 45/127 (35%), Positives = 74/127 (58%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
IFS +FYT ++GYKMCL + +G G G GTHLS++F +MKG D +L+WPF V L L+
Sbjct: 376 IFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLL 435
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNANLILNNQIFI 360
+ Q +H D + D + + +P+N+ G F + ++ + + ++ IFI
Sbjct: 436 D-QNNREHVIDAFR-PDVTSSSF-QRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFI 492
Query: 361 KCSVNIS 381
K V+++
Sbjct: 493 KAIVDLT 499
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 84.0 bits (206), Expect = 3e-16
Identities = 45/127 (35%), Positives = 73/127 (57%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
IFS +FYT ++GYKMCL V +G G G GTHLS++F +MKG D +LQWPF V L L+
Sbjct: 376 IFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLL 435
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKELSTNANLILNNQIFI 360
+ +H D + D + + +P+++ G F + ++ + + ++ IFI
Sbjct: 436 D-HNNREHVIDAFR-PDVTSSSF-QRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFI 492
Query: 361 KCSVNIS 381
K V+++
Sbjct: 493 KAIVDLT 499
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 79.3 bits (194), Expect = 7e-15
Identities = 45/128 (35%), Positives = 75/128 (58%), Gaps = 1/128 (0%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
+FS +FYT K+GYK+CL + +G G+G+ THLS++ +M+GE+D +L WPF+ V L+
Sbjct: 284 LFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLL 343
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKEL-STNANLILNNQIF 357
+ Q +HA D + D + + +P +E G F L +L S + ++ +F
Sbjct: 344 D-QNNREHAIDAFR-PDLSSASF-QRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMF 400
Query: 358 IKCSVNIS 381
+KC V+ S
Sbjct: 401 LKCIVDTS 408
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 78.6 bits (192), Expect = 1e-14
Identities = 45/128 (35%), Positives = 73/128 (57%), Gaps = 1/128 (0%)
Frame = +1
Query: 1 IFSDSFYTHKHGYKMCLSVCPDGAGAGEGTHLSVYFHLMKGEFDDILQWPFKYDVRLSLI 180
+FS +FYT K+GYK+CL + +G G G+ THLS++ +M+GE+D +L WPF+ V L+
Sbjct: 291 LFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLL 350
Query: 181 NQQTGLDHASDTTKYVDFPNDKYWNKPINEGIAGFGTSQFIELKEL-STNANLILNNQIF 357
+ Q +HA D + D + + +P +E G F L +L S + ++ +F
Sbjct: 351 D-QNNREHAIDAFR-PDLSSASF-QRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMF 407
Query: 358 IKCSVNIS 381
+KC V S
Sbjct: 408 LKCIVETS 415
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,419,369
Number of Sequences: 369166
Number of extensions: 1297694
Number of successful extensions: 2771
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2713
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2765
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4895780500
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)