Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02430
(855 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P40126|TYRP2_HUMAN Dopachrome tautomerase precursor (DT)... 86 1e-16
sp|O93505|TYRP2_CHICK Dopachrome tautomerase precursor (DT)... 86 1e-16
sp|Q04604|TYRO_RANNI Tyrosinase precursor (Monophenol monoo... 86 2e-16
sp|P29812|TYRP2_MOUSE Dopachrome tautomerase precursor (DT)... 85 2e-16
sp|Q8MIU0|TYRO_BOVIN Tyrosinase precursor (Monophenol monoo... 84 7e-16
sp|P55025|TYRO_ORYLA Tyrosinase precursor (Monophenol monoo... 80 7e-15
sp|P54834|TYRO_CANFA Tyrosinase precursor (Monophenol monoo... 80 9e-15
sp|P55028|TYRP1_CARAU 5,6-dihydroxyindole-2-carboxylic acid... 79 1e-14
sp|P55024|TYRO_CHICK Tyrosinase precursor (Monophenol monoo... 79 2e-14
sp|P11344|TYRO_MOUSE Tyrosinase precursor (Monophenol monoo... 79 2e-14
>sp|P40126|TYRP2_HUMAN Dopachrome tautomerase precursor (DT) (DCT) (Dopachrome
delta-isomerase) (Tyrosinase-related protein 2) (TRP-2)
(TRP2)
Length = 519
Score = 85.9 bits (211), Expect = 1e-16
Identities = 55/163 (33%), Positives = 84/163 (51%), Gaps = 5/163 (3%)
Frame = +1
Query: 25 SVQYMLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIAR 204
SV V++H + R T+ + + ++F+H+ F TWHRY+++ ER LQ +
Sbjct: 180 SVYDFFVWLHYYSVRDTLLGPG---RPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRL-- 234
Query: 205 KEFGIKNFALPYWDW-TGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQEPD 381
G ++FALPYW++ TG+ CD+CTD + GA R D IS S F +W C D
Sbjct: 235 --IGNESFALPYWNFATGRNECDVCTDQLFGAA--RPDDPTLISRNSRFSSWETVC---D 287
Query: 382 NADESPCYGCHVTGTYGKITRE----WNSLEFPTISDVEFVLS 498
+ D+ GTY + R NS++ PT+ D+ LS
Sbjct: 288 SLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLS 330
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/66 (33%), Positives = 38/66 (57%), Gaps = 5/66 (7%)
Frame = +3
Query: 600 SFHRALEGMCGQPEKA-----SDLFYMHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDR 764
SF ALEG +KA S + +HN +H+ ++G+ +A +DP+F+ H+ TD
Sbjct: 346 SFRNALEGF----DKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDA 401
Query: 765 IFEVYL 782
IF+ ++
Sbjct: 402 IFDEWM 407
>sp|O93505|TYRP2_CHICK Dopachrome tautomerase precursor (DT) (DCT) (Dopachrome
delta-isomerase) (Tyrosinase-related protein 2) (TRP-2)
(TRP2)
Length = 521
Score = 85.9 bits (211), Expect = 1e-16
Identities = 56/162 (34%), Positives = 85/162 (52%), Gaps = 3/162 (1%)
Frame = +1
Query: 25 SVQYMLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIAR 204
S+ V++H + R T+ + F ++F+H+ F TWHRY+++ ER LQ +
Sbjct: 182 SIYNYFVWLHYYSVRDTLLGPG---RPFTAIDFSHQGPAFVTWHRYHLLLLERDLQRL-- 236
Query: 205 KEFGIKNFALPYWDW-TGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQEPD 381
G ++FALPYWD+ TG+ +CD+CTD + GAP R D ISL S F W C D
Sbjct: 237 --MGNESFALPYWDFATGRNTCDVCTDQLFGAP--RPDDPGLISLNSRFSRWQIVCNSLD 292
Query: 382 NADE--SPCYGCHVTGTYGKITREWNSLEFPTISDVEFVLSK 501
+ + + C G G + R+ + + PT DV LS+
Sbjct: 293 DYNRLVTLCNGSD-EGLLQRRPRD-SGEQLPTAEDVRRCLSR 332
Score = 43.9 bits (102), Expect = 6e-04
Identities = 23/63 (36%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Frame = +3
Query: 600 SFHRALEGMCGQPEKA--SDLFYMHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDRIFE 773
SF ALEG +PE A S + +HN H+ ++G+ A +DP+F+ H+ TD IF+
Sbjct: 347 SFRNALEGF-NKPEGALNSPMLNLHNLAHSFLNGTRVLPHAAANDPIFVVLHSFTDAIFD 405
Query: 774 VYL 782
++
Sbjct: 406 EWM 408
>sp|Q04604|TYRO_RANNI Tyrosinase precursor (Monophenol monooxygenase)
Length = 532
Score = 85.5 bits (210), Expect = 2e-16
Identities = 52/159 (32%), Positives = 78/159 (49%), Gaps = 5/159 (3%)
Frame = +1
Query: 37 MLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIARKEFG 216
+ V+IH + SR ED + ++F HEA GF WHR+Y++ WER +Q + G
Sbjct: 179 LFVWIHYYASRDAFLEDG---SVWADIDFAHEAPGFLPWHRFYLLLWEREIQKVT----G 231
Query: 217 IKNFALPYWDWTGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQEPD--NAD 390
NF +P+WDW C++CTD+ G G +S S F +W C P+ N+
Sbjct: 232 DDNFTIPFWDWRDAQQCELCTDEFFG--GTHPTSNNLLSPASFFSSWQIICSRPEEYNSL 289
Query: 391 ESPCYGCH---VTGTYGKITREWNSLEFPTISDVEFVLS 498
C G + + + G+ R + PT +DVE LS
Sbjct: 290 RIICNGTNEGPLLRSPGRHDRN-RTPRLPTSADVEACLS 327
Score = 42.0 bits (97), Expect = 0.002
Identities = 21/63 (33%), Positives = 32/63 (50%), Gaps = 2/63 (3%)
Frame = +3
Query: 600 SFHRALEGMCGQPEKASDLFY--MHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDRIFE 773
SF LEG ++ MHN +H ++GSM + +DP+F+ HH D +FE
Sbjct: 343 SFRNTLEGFAVPTSGIANRSQSSMHNSLHVFLNGSMSSVQGSANDPIFVLHHAFVDSLFE 402
Query: 774 VYL 782
+L
Sbjct: 403 QWL 405
>sp|P29812|TYRP2_MOUSE Dopachrome tautomerase precursor (DT) (DCT) (Dopachrome
delta-isomerase) (Tyrosinase-related protein 2) (TRP-2)
(TRP2) (SLATY locus protein)
Length = 517
Score = 85.1 bits (209), Expect = 2e-16
Identities = 57/166 (34%), Positives = 85/166 (51%), Gaps = 8/166 (4%)
Frame = +1
Query: 25 SVQYMLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIAR 204
SV V++H + R T+ + + ++F+H+ F TWHRY++++ ER LQ +
Sbjct: 180 SVYDFFVWLHYYSVRDTLLGPG---RPYKAIDFSHQGPAFVTWHRYHLLWLERELQRLT- 235
Query: 205 KEFGIKNFALPYWDW-TGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQEPD 381
G ++FALPYW++ TG+ CD+CTDD GA R D IS S F W C D
Sbjct: 236 ---GNESFALPYWNFATGKNECDVCTDDWLGAA--RQDDPTLISRNSRFSTWEIVCDSLD 290
Query: 382 NADESPCYGCHVT---GTYGKITRE----WNSLEFPTISDVEFVLS 498
+ Y VT GTY + R N+ + PT+ +V+ LS
Sbjct: 291 D------YNRRVTLCNGTYEGLLRRNKVGRNNEKLPTLKNVQDCLS 330
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/66 (34%), Positives = 37/66 (56%), Gaps = 5/66 (7%)
Frame = +3
Query: 600 SFHRALEGMCGQPEKA-----SDLFYMHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDR 764
SF ALEG +KA S + +HN H+ ++G+ +A +DP+F+ H+ TD
Sbjct: 346 SFRNALEGF----DKADGTLDSQVMNLHNLAHSFLNGTNALPHSAANDPVFVVLHSFTDA 401
Query: 765 IFEVYL 782
IF+ +L
Sbjct: 402 IFDEWL 407
>sp|Q8MIU0|TYRO_BOVIN Tyrosinase precursor (Monophenol monooxygenase)
Length = 530
Score = 83.6 bits (205), Expect = 7e-16
Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 8/166 (4%)
Frame = +1
Query: 25 SVQYMLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIAR 204
SV + V++H + SR T+ D + + ++F HEA GF WHR +++ WE+ +Q +
Sbjct: 171 SVYDLFVWMHYYVSRDTLLGD---SEVWRDIDFAHEAPGFLPWHRLFLLLWEQEIQKLT- 226
Query: 205 KEFGIKNFALPYWDWTGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQ--EP 378
G +NF +PYWDW +CD+CTD+ G G + +S S F +W C E
Sbjct: 227 ---GDENFTIPYWDWRDAENCDVCTDEYMG--GRNPANPNLLSPASFFSSWQIVCSRLEE 281
Query: 379 DNADESPCYGCHVTGTYGKITR------EWNSLEFPTISDVEFVLS 498
N+ ++ C G + G + R + + P+ +DVEF LS
Sbjct: 282 YNSRQALCNGT----SEGPLLRNPGNHDKARTPRLPSSADVEFCLS 323
Score = 41.6 bits (96), Expect = 0.003
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 2/63 (3%)
Frame = +3
Query: 600 SFHRALEGMCGQPEKASDLFY--MHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDRIFE 773
SF LEG +D MHN +H ++G+M + +DP+F+ HH D IFE
Sbjct: 339 SFRNTLEGFADPVTGIADASQSSMHNALHIYMNGTMSQVPGSANDPIFLLHHAFVDSIFE 398
Query: 774 VYL 782
+L
Sbjct: 399 QWL 401
>sp|P55025|TYRO_ORYLA Tyrosinase precursor (Monophenol monooxygenase)
Length = 540
Score = 80.1 bits (196), Expect = 7e-15
Identities = 54/164 (32%), Positives = 79/164 (48%), Gaps = 8/164 (4%)
Frame = +1
Query: 37 MLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIARKEFG 216
+ V+IH + SR T + + ++F HE+ F WHR Y++ WE+ + RK G
Sbjct: 177 LFVWIHYYVSRDTFLGGPGNV--WRDIDFAHESAAFLPWHRVYLLHWEQEI----RKITG 230
Query: 217 IKNFALPYWDWTGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFC--QEPDNAD 390
NF +PYWDW SC++CTD++ G G + IS S F +W C QE N
Sbjct: 231 DFNFTIPYWDWRDAQSCEVCTDNLMG--GRNALNPNLISPASVFSSWKVICTQQEEYNNQ 288
Query: 391 ESPCYGCHVTGTYGKITREWNSLE------FPTISDVEFVLSKP 504
E+ C G + R + + PT +DVEF +S P
Sbjct: 289 EALCNAT----AEGPLLRNPGNHDPNRVPRIPTTADVEFTISLP 328
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 5/105 (4%)
Frame = +3
Query: 483 RIRSF*TSVNILFISNLPK--AFNLNRFHVSGERVTDTACESFHRALEGMCGQPEKASDL 656
R+ T+ ++ F +LP+ +++RF A SF LEG PE +
Sbjct: 311 RVPRIPTTADVEFTISLPEYETGSMDRF----------ANNSFRNVLEGFAS-PETGMAV 359
Query: 657 ---FYMHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDRIFEVYL 782
MHN +H ++GSM + +DP+F+ HH D IFE +L
Sbjct: 360 QGQSTMHNALHVFMNGSMSSVQGSANDPIFLLHHAFIDSIFERWL 404
>sp|P54834|TYRO_CANFA Tyrosinase precursor (Monophenol monooxygenase)
Length = 530
Score = 79.7 bits (195), Expect = 9e-15
Identities = 52/162 (32%), Positives = 80/162 (49%), Gaps = 8/162 (4%)
Frame = +1
Query: 37 MLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIARKEFG 216
+ V++H + SR T+ + + ++F HEA GF WHR +++ WE+ +Q + G
Sbjct: 175 LFVWMHYYVSRDTLLGG---SEIWKDIDFAHEAPGFLPWHRLFLLLWEQEIQKLT----G 227
Query: 217 IKNFALPYWDWTGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQ--EPDNAD 390
+NF +PYWDW SCDICTD+ G G + +S S F +W C E N+
Sbjct: 228 DENFTIPYWDWRDAKSCDICTDEYMG--GRNPANPNLLSPASFFSSWQIVCTRLEEYNSR 285
Query: 391 ESPCYG------CHVTGTYGKITREWNSLEFPTISDVEFVLS 498
++ C G G + K + P+ +DVEF LS
Sbjct: 286 QALCDGTPEGPLLRNPGNHDKA----RTPRLPSSADVEFCLS 323
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 2/82 (2%)
Frame = +3
Query: 543 FNLNRFHVSGERVTDTACESFHRALEGMCGQPEKASDLFY--MHNKIHNMIDGSMCCSGT 716
F L+ + + A SF LEG +D MHN +H ++G+M
Sbjct: 320 FCLSLTQYESDSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVPG 379
Query: 717 APSDPLFIFHHTQTDRIFEVYL 782
+ +DP+F+ HH D IFE +L
Sbjct: 380 SANDPIFLLHHAFVDSIFEQWL 401
>sp|P55028|TYRP1_CARAU 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor (DHICA
oxidase) (Tyrosinase-related protein 1) (TRP-1) (TRP1)
Length = 522
Score = 79.3 bits (194), Expect = 1e-14
Identities = 45/123 (36%), Positives = 65/123 (52%), Gaps = 1/123 (0%)
Frame = +1
Query: 25 SVQYMLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIAR 204
S+ + V+ H + T D +FG ++F+HE GF TWHRY+++ ER +Q +
Sbjct: 173 SIYNLFVWTHYYSVSKTFLGAGQD--SFGGVDFSHEGPGFLTWHRYHLLQLERDMQVM-- 228
Query: 205 KEFGIKNFALPYWDWT-GQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQEPD 381
G +FALPYWD+ G + CDICTD++ GA D IS S F W C+ +
Sbjct: 229 --LGDPSFALPYWDFAIGGSECDICTDELMGARS--SSDSSSISSNSIFSRWRVICESVE 284
Query: 382 NAD 390
D
Sbjct: 285 EYD 287
Score = 39.7 bits (91), Expect = 0.011
Identities = 21/67 (31%), Positives = 39/67 (58%), Gaps = 2/67 (2%)
Frame = +3
Query: 588 TACESFHRALEGMCGQPEKASD--LFYMHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTD 761
T+ +SF ++EG P+ D + +HN H ++G+ + +P+DP+F+ HT TD
Sbjct: 340 TSSDSFRNSIEGYSA-PQGNYDPVVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTD 398
Query: 762 RIFEVYL 782
+F+ +L
Sbjct: 399 AVFDEWL 405
>sp|P55024|TYRO_CHICK Tyrosinase precursor (Monophenol monooxygenase)
Length = 529
Score = 78.6 bits (192), Expect = 2e-14
Identities = 51/164 (31%), Positives = 81/164 (49%), Gaps = 6/164 (3%)
Frame = +1
Query: 25 SVQYMLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIAR 204
+V + V++H + SR T+ ++ ++F HEA GF WHR +++ WER +Q I
Sbjct: 171 NVYDLFVWMHYYASRDTLLGGSNVWRD---IDFAHEAPGFLPWHRAFLLLWEREIQKIT- 226
Query: 205 KEFGIKNFALPYWDWTGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFCQEPDN 384
G +NF +PYWDW C ICTD+ G G + +S S F +W C + +
Sbjct: 227 ---GDENFTIPYWDWRDAEDCVICTDEYMG--GQHPTNPNLLSPASFFSSWQVICTQSEE 281
Query: 385 ADESPCYGCHVTGTYGKITR------EWNSLEFPTISDVEFVLS 498
+ C+ T + G I R + + P+ S+VEF L+
Sbjct: 282 YNSQQAL-CNAT-SEGPILRNPGNNDKSRTPRLPSSSEVEFCLT 323
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/63 (36%), Positives = 33/63 (52%), Gaps = 2/63 (3%)
Frame = +3
Query: 600 SFHRALEGMCGQPEKASDLFY--MHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDRIFE 773
SF LEG S++ +HN +H ++GSM + +DP+FI HH D IFE
Sbjct: 339 SFRNTLEGFADPHTAISNISQSGLHNALHIYMNGSMSQVQGSANDPIFILHHAFVDSIFE 398
Query: 774 VYL 782
+L
Sbjct: 399 RWL 401
>sp|P11344|TYRO_MOUSE Tyrosinase precursor (Monophenol monooxygenase) (Albino locus
protein)
Length = 533
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/162 (30%), Positives = 81/162 (50%), Gaps = 8/162 (4%)
Frame = +1
Query: 37 MLVFIHRFGSRATMFEDYLDCQNFGILNFNHEAIGFATWHRYYMMFWERLLQDIARKEFG 216
+ V++H + SR T+ + + ++F HEA GF WHR +++ WE+ ++++ G
Sbjct: 175 LFVWMHYYVSRDTLLGG---SEIWRDIDFAHEAPGFLPWHRLFLLLWEQEIRELT----G 227
Query: 217 IKNFALPYWDWTGQTSCDICTDDMAGAPGFRDKDGVRISLRSPFGNWTEFC--QEPDNAD 390
+NF +PYWDW +CDICTD+ G G ++ +S S F +W C E N+
Sbjct: 228 DENFTVPYWDWRDAENCDICTDEYLG--GRHPENPNLLSPASFFSSWQIICSRSEEYNSH 285
Query: 391 ESPCYG------CHVTGTYGKITREWNSLEFPTISDVEFVLS 498
+ C G G + K + P+ +DVEF LS
Sbjct: 286 QVLCDGTPEGPLLRNPGNHDKA----KTPRLPSSADVEFCLS 323
Score = 39.7 bits (91), Expect = 0.011
Identities = 22/62 (35%), Positives = 34/62 (54%)
Frame = +3
Query: 597 ESFHRALEGMCGQPEKASDLFYMHNKIHNMIDGSMCCSGTAPSDPLFIFHHTQTDRIFEV 776
E F L G+ P ++S MHN +H ++G+M + +DP+F+ HH D IFE
Sbjct: 345 EVFASPLTGIA-DPSQSS----MHNALHIFMNGTMSQVQGSANDPIFLLHHAFVDSIFEQ 399
Query: 777 YL 782
+L
Sbjct: 400 WL 401
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 103,651,241
Number of Sequences: 369166
Number of extensions: 2262455
Number of successful extensions: 5357
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5082
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5319
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)