Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02403
(851 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8VHX6|FLNC_MOUSE Filamin-C (Gamma-filamin) (Filamin-2) ... 230 3e-60
sp|Q14315|FLNC_HUMAN Filamin-C (Gamma-filamin) (Filamin-2) ... 228 1e-59
sp|P21333|FLNA_HUMAN Filamin-A (Alpha-filamin) (Filamin-1) ... 227 4e-59
sp|Q8BTM8|FLNA_MOUSE Filamin-A (Alpha-filamin) (Filamin-1) ... 227 4e-59
sp|O75369|FLNB_HUMAN Filamin-B (FLN-B) (Beta-filamin) (Acti... 225 1e-58
sp|Q9MZD2|FLNB_RABIT Filamin-B (FLN-B) (Beta-filamin) (Acti... 225 1e-58
sp|Q80X90|FLNB_MOUSE Filamin-B (FLN-B) (Beta-filamin) (Acti... 215 1e-55
sp|P13466|GELA_DICDI Gelation factor (Actin binding protein... 58 3e-08
sp|Q9R1R2|TRIM3_MOUSE Tripartite motif protein 3 (RING fing... 37 0.069
sp|Q6PFY8|TRI45_MOUSE Tripartite motif protein 45 37 0.091
>sp|Q8VHX6|FLNC_MOUSE Filamin-C (Gamma-filamin) (Filamin-2) (FLN-C) (Actin-binding-like
protein) (ABP-L) (ABP-280-like protein)
Length = 1144
Score = 230 bits (587), Expect = 3e-60
Identities = 122/262 (46%), Positives = 164/262 (62%), Gaps = 8/262 (3%)
Frame = +1
Query: 4 QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
++ ++F P E+G H + V+ N I GSPF+I VG + DPG+V A G GL
Sbjct: 882 KHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGV 941
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
+ F VNT NAGSG+L+V IDGPSKV ++C E EG+ TY APGNY+I I YGG H
Sbjct: 942 SSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQH 1001
Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDKRCVSQYAE-----KTTSYAEKVICQG 519
IVGSPF A G + +G + + S V +E K S+ A K +S A KV+ +G
Sbjct: 1002 IVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRG 1061
Query: 520 LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
GL QA + NSF VD S+AG +++VG+ GP PCEEV V+H+GN + V Y VKE G
Sbjct: 1062 PGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKG 1121
Query: 700 THIIMVRWGDKDIPGSPFMVHV 765
+I++V+WGD+ +PGSPF V+V
Sbjct: 1122 DYILIVKWGDESVPGSPFKVNV 1143
Score = 107 bits (266), Expect = 5e-23
Identities = 58/130 (44%), Positives = 77/130 (59%), Gaps = 2/130 (1%)
Frame = +1
Query: 10 GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
G+ FTP+E G H+V V + K + SPF+I VG D V G+GLS + A
Sbjct: 421 GISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAE 480
Query: 187 FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
F V+T NAG G L ++I+GPSKV++NC + E+G + TY T PG YIINI + H+
Sbjct: 481 FIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADK-HVP 539
Query: 364 GSPFTAVCEG 393
GSPFT G
Sbjct: 540 GSPFTVKVTG 549
Score = 99.4 bits (246), Expect = 1e-20
Identities = 75/256 (29%), Positives = 114/256 (44%), Gaps = 1/256 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V++ P E G H + ++ + I GSP + V N+ V A G GLS +V+K
Sbjct: 239 GTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRH--VSAYGPGLSHGMVNKP 296
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
A F + T +AG G L++A++GPSK + C + ++G +Y+ TAPG+Y I + + H
Sbjct: 297 ATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-H 355
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I GSPFTA +I D SQ T++ I +G
Sbjct: 356 IPGSPFTA------------------KITGDDSMRTSQLNVGTSTDVSLKITEG------ 391
Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
D SQ L I P E +++ + N + + KE G H++ V
Sbjct: 392 ----------DLSQ-----LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSV 436
Query: 718 RWGDKDIPGSPFMVHV 765
R K + SPF + V
Sbjct: 437 RKSGKHVTNSPFKILV 452
Score = 99.0 bits (245), Expect = 1e-20
Identities = 78/255 (30%), Positives = 118/255 (46%), Gaps = 2/255 (0%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
Y V+F P+E G H V V+ + + GSPF+ VG V A G GL R V A
Sbjct: 693 YSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPA 752
Query: 184 HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
F + T AG+G L++A++GPSK + + ++G +YV PG+Y ++I + HI
Sbjct: 753 EFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDE-HI 811
Query: 361 VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
SPF V + D R ++ TS E GLK
Sbjct: 812 PDSPFVV----------------PVASLSDDARRLT-----VTSLQE------TGLK--- 841
Query: 541 LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
+N SF V + A G++ + P EE V + +++ T+ ++ E+G H I V+
Sbjct: 842 VNQPASFAVQLNGA-RGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVK 900
Query: 721 WGDKDIPGSPFMVHV 765
+ IPGSPF + V
Sbjct: 901 FNGAHIPGSPFKIRV 915
Score = 67.0 bits (162), Expect = 6e-11
Identities = 64/258 (24%), Positives = 96/258 (37%), Gaps = 3/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P G + + V + K I GSPF + D M S+ V
Sbjct: 331 GTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI---TGDDSM------RTSQLNVGTS 381
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAP---GNYIINITYGGN 351
+ T L +I PS C ++ P G +++++ G
Sbjct: 382 TDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGK 441
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H+ SPF + ++ GD A KV G GL
Sbjct: 442 -HVTNSPFKILVGPSEIGD-----------------------------ASKVRVWGKGLS 471
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+ + V F VD AGYG L + I GP + ++ + + V Y E GT+II
Sbjct: 472 EGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKV--DINCEDMEDGTCKVTYCPTEPGTYII 529
Query: 712 MVRWGDKDIPGSPFMVHV 765
+++ DK +PGSPF V V
Sbjct: 530 NIKFADKHVPGSPFTVKV 547
Score = 66.6 bits (161), Expect = 8e-11
Identities = 70/262 (26%), Positives = 106/262 (40%), Gaps = 7/262 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G GV + +E G + V ++ N + I SPF +PV + D + T + V++
Sbjct: 786 GSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQP 845
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
A F V N G ++ + PS C+ +E + + ++ G + I++ + G
Sbjct: 846 ASFAVQ-LNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNG- 903
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
HI GSPF V + SQ A D VS Y G GL+
Sbjct: 904 AHIPGSPF----------KIRVGEQSQ----AGDPGLVSAY--------------GPGLE 935
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
+ F V+ AG G L V I GP + C E HV V Y G
Sbjct: 936 GGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHV------VTYTPMAPGN 989
Query: 703 HIIMVRW-GDKDIPGSPFMVHV 765
++I +++ G + I GSPF V
Sbjct: 990 YLIAIKYGGPQHIVGSPFKAKV 1011
Score = 63.9 bits (154), Expect = 5e-10
Identities = 71/275 (25%), Positives = 114/275 (41%), Gaps = 19/275 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLS---- 159
G Y V + P SG + + ++ I SPFRI P G + V G GL
Sbjct: 15 GTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLG 74
Query: 160 -RAVVDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
R + ++ V+ AG G + + P ++++++ E +G ++ Y A PG Y+
Sbjct: 75 PRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYV 134
Query: 328 INITYGGNFHIVGSPF-TAVCEGTKTGD--TEVEQHSQVEIEASDKRCVSQYAEKTTSYA 498
I I +GG HI SPF C+ + E+ Q Q C + +A +
Sbjct: 135 ITIRFGGE-HIPNSPFHVLACDPLPHVEEPAEMLQMRQPYAPLRPGTCPTHWATE----- 188
Query: 499 EKVI-CQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ-- 666
E V+ + L N V F V + + G VR P + ++ +N+
Sbjct: 189 EPVVPVEPLESMLRPFNLVIPFTVQKGE---------LTGEVRMPSGKTARPNITDNKDG 239
Query: 667 -FTVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
TV Y E G H + +++ IPGSP +VD
Sbjct: 240 TITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVD 274
Score = 48.5 bits (114), Expect = 2e-05
Identities = 73/322 (22%), Positives = 115/322 (35%), Gaps = 67/322 (20%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P E GT+++ ++ K + GSPF + V TGEG + + ++
Sbjct: 513 GTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKV------------TGEGRMKESITRR 560
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHE--TEEGYEFTYVATAPGNYIINITYGG-- 348
T + LN+ I G ++ E T ++ T I+ T GG
Sbjct: 561 RQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGET 620
Query: 349 --------NFHIVGSPFTAVC-------------------EG------------TKTGDT 411
+ + G PF AV EG + +G T
Sbjct: 621 KREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKT 680
Query: 412 EVEQHSQVEIEASDKRCVSQYA---EKTTSY---------------------AEKVICQG 519
E + + E A R V Q T Y A KV G
Sbjct: 681 EAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGG 740
Query: 520 LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
GL++ F + +AG G L + + GP + E+ + V YVV+E G
Sbjct: 741 TGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSK--AEIAFEDRKDGSCGVSYVVQEPG 798
Query: 700 THIIMVRWGDKDIPGSPFMVHV 765
+ + +++ D+ IP SPF+V V
Sbjct: 799 DYEVSIKFNDEHIPDSPFVVPV 820
Score = 37.7 bits (86), Expect = 0.041
Identities = 15/40 (37%), Positives = 25/40 (62%)
Frame = +1
Query: 643 VRHVGNNQFTVDYVVKESGTHIIMVRWGDKDIPGSPFMVH 762
+R G+ +TV Y+ SG + I +++G +IP SPF +H
Sbjct: 9 IRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIH 48
>sp|Q14315|FLNC_HUMAN Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc)
(Actin-binding-like protein) (ABP-L) (ABP-280-like
protein)
Length = 2725
Score = 228 bits (582), Expect = 1e-59
Identities = 121/262 (46%), Positives = 163/262 (62%), Gaps = 8/262 (3%)
Frame = +1
Query: 4 QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
++ ++F P E+G H + V+ N I GSPF+I VG + DPG+V A G GL
Sbjct: 2463 KHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGV 2522
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
+ F VNT NAGSG+L+V IDGPSKV ++C E EG+ TY APGNY+I I YGG H
Sbjct: 2523 SSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQH 2582
Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDKRCVSQYAE-----KTTSYAEKVICQG 519
IVGSPF A G + +G + + S V +E K S+ + K +S A KV+ +G
Sbjct: 2583 IVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRG 2642
Query: 520 LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
GL QA + NSF VD S+AG +++VG+ GP PCEEV V+H+GN + V Y VKE G
Sbjct: 2643 PGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKG 2702
Query: 700 THIIMVRWGDKDIPGSPFMVHV 765
+I++V+WGD+ +PGSPF V V
Sbjct: 2703 DYILIVKWGDESVPGSPFKVKV 2724
Score = 127 bits (320), Expect = 3e-29
Identities = 87/257 (33%), Positives = 120/257 (46%), Gaps = 2/257 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y V++T E G H+V V ++ + SPFR+ V DP V A G GL +V+K
Sbjct: 1310 GTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTE-GCDPTRVRAFGPGLEGGLVNKA 1368
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
F V T AG+G L +AI+GPS+ M+C + ++G Y+ PG+Y +NIT+GG
Sbjct: 1369 NRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGR-P 1427
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL-KQ 534
I GSPF + K KV C G GL
Sbjct: 1428 IPGSPF-------------------------------RVPVKDVVDPGKVKCSGPGLGAG 1456
Query: 535 ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
R +F VD SQAG L V + GP E V VR G+ TV Y G + +
Sbjct: 1457 VRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVA 1516
Query: 715 VRWGDKDIPGSPFMVHV 765
V++ D+++P SPF + V
Sbjct: 1517 VKYADQEVPRSPFKIKV 1533
Score = 106 bits (265), Expect = 7e-23
Identities = 58/130 (44%), Positives = 77/130 (59%), Gaps = 2/130 (1%)
Frame = +1
Query: 10 GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
G+ FTP+E G H+V V + K + SPF+I VG D V G+GLS + A
Sbjct: 2002 GISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAE 2061
Query: 187 FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
F V+T NAG G L ++I+GPSKV++NC + E+G + TY T PG YIINI + H+
Sbjct: 2062 FIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADK-HVP 2120
Query: 364 GSPFTAVCEG 393
GSPFT G
Sbjct: 2121 GSPFTVKVTG 2130
Score = 103 bits (258), Expect = 5e-22
Identities = 70/252 (27%), Positives = 110/252 (43%), Gaps = 1/252 (0%)
Frame = +1
Query: 13 VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFF 192
V++ P E G + V + + P+ GSPF + G DP V A G GL +V A F
Sbjct: 1026 VRYMPPEEGPYKVDITYDGHPVPGSPFAVE-GVLPPDPSKVCAYGPGLKGGLVGTPAPFS 1084
Query: 193 VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGS 369
++T AG+G L + ++GP + + C + +G +Y+ T PG Y INI + HI GS
Sbjct: 1085 IDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILF-AEAHIPGS 1143
Query: 370 PFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNS 549
PF A + KV G GL++ ++
Sbjct: 1144 PFKATI-------------------------------RPVFDPSKVRASGPGLERGKVGE 1172
Query: 550 VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGD 729
+F VD S+AG L + I EV++ + + + + Y GT+ I +++G
Sbjct: 1173 AATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGG 1232
Query: 730 KDIPGSPFMVHV 765
+P P VHV
Sbjct: 1233 HPVPKFPTRVHV 1244
Score = 97.1 bits (240), Expect = 6e-20
Identities = 74/256 (28%), Positives = 113/256 (44%), Gaps = 1/256 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V++ P E G H + ++ + I GSP + V N+ V A G GLS +V+K
Sbjct: 1820 GTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRH--VSAYGPGLSHGMVNKP 1877
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
A F + T +AG G L++A++GPSK + C + ++G +Y+ TAPG+Y I + + H
Sbjct: 1878 ATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-H 1936
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I GSPFTA +I D SQ T++ I +
Sbjct: 1937 IPGSPFTA------------------KITGDDSMRTSQLNVGTSTDVSLKITES------ 1972
Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
D SQ L I P E +++ + N + + KE G H++ V
Sbjct: 1973 ----------DLSQ-----LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSV 2017
Query: 718 RWGDKDIPGSPFMVHV 765
R K + SPF + V
Sbjct: 2018 RKSGKHVTNSPFKILV 2033
Score = 95.9 bits (237), Expect = 1e-19
Identities = 77/255 (30%), Positives = 117/255 (45%), Gaps = 2/255 (0%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
Y V+F P+E G H V V+ + + GSPF+ VG V A GL R V A
Sbjct: 2274 YSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGRAGLERGVAGVPA 2333
Query: 184 HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
F + T AG+G L++A++GPSK + + ++G +YV PG+Y ++I + HI
Sbjct: 2334 EFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDE-HI 2392
Query: 361 VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
SPF V + D R ++ TS E GLK
Sbjct: 2393 PDSPFVV----------------PVASLSDDARRLT-----VTSLQE------TGLK--- 2422
Query: 541 LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
+N SF V + A G++ + P EE V + +++ T+ ++ E+G H I V+
Sbjct: 2423 VNQPASFAVQLNGA-RGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVK 2481
Query: 721 WGDKDIPGSPFMVHV 765
+ IPGSPF + V
Sbjct: 2482 FNGAHIPGSPFKIRV 2496
Score = 84.3 bits (207), Expect = 4e-16
Identities = 73/260 (28%), Positives = 108/260 (41%), Gaps = 6/260 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V++ P G + V + +PI GSPFR+PV DPG V +G GL V +
Sbjct: 1403 GSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDV-VDPGKVKCSGPGLGAGVRARV 1461
Query: 181 AHFF-VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGG 348
F V+ + AG L VA+ GP+ V + G + Y G Y + + Y
Sbjct: 1462 PQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYAD 1521
Query: 349 NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
+ SPF + A D A KV G GL
Sbjct: 1522 Q-EVPRSPFKIKV-----------------LPAHD--------------ASKVRASGPGL 1549
Query: 529 KQARLNSVN--SFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
+ + + F +DA AG G+L V I GP ++ +R G+ + V Y+ SG
Sbjct: 1550 NASGIPASLPVEFTIDARDAGEGLLTVQILGPEGKPKKANIRDNGDGTYAVSYLPDMSGR 1609
Query: 703 HIIMVRWGDKDIPGSPFMVH 762
+ I +++G +IP SPF +H
Sbjct: 1610 YTITIKYGGDEIPYSPFRIH 1629
Score = 79.7 bits (195), Expect = 9e-15
Identities = 72/263 (27%), Positives = 102/263 (38%), Gaps = 7/263 (2%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRA--VVDKK 180
Y V + P+ +G H V V + I SPF + VG D V A G GL V +K
Sbjct: 336 YAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKP 395
Query: 181 AHFFVNTTNAGSGSLNVAIDGPS----KVNMNCHETEEG-YEFTYVATAPGNYIINITYG 345
+F + T AG+G + V I P V + + + + TY G + +++ +
Sbjct: 396 TYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAFA 455
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G I SPF +E A + +GL
Sbjct: 456 GA-PITRSPFPV-----------------------------HVSEACNPNACRASGRGLQ 485
Query: 526 LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
K R+ V F V AG G L V + GP E V VR G+ F +Y G +
Sbjct: 486 PKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKY 545
Query: 706 IIMVRWGDKDIPGSPFMVHVD*E 774
++ + WG IP SPF V V E
Sbjct: 546 VVTITWGGYAIPRSPFEVQVSPE 568
Score = 79.3 bits (194), Expect = 1e-14
Identities = 75/254 (29%), Positives = 99/254 (38%), Gaps = 5/254 (1%)
Frame = +1
Query: 19 FTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK--AHFF 192
+ P G H V V PI SPF + V +P A+G GL V K A F
Sbjct: 440 YRPAMEGPHTVHVAFAGAPITRSPFPVHVSEA-CNPNACRASGRGLQPKGVRVKEVADFK 498
Query: 193 VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGGNFHIV 363
V T AGSG L V + GP E G +E Y PG Y++ IT+GG + I
Sbjct: 499 VFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGG-YAIP 557
Query: 364 GSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARL 543
SPF QV EA +KV G GL+ ++
Sbjct: 558 RSPFEV----------------QVSPEAG---------------VQKVRAWGPGLETGQV 586
Query: 544 NSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRW 723
F V+A G L I GP + ++ G+ V Y E G + + V
Sbjct: 587 GKSADFVVEAIGTEVGTLGFSIEGPSQ--AKIECDDKGDGSCDVRYWPTEPGEYAVHVIC 644
Query: 724 GDKDIPGSPFMVHV 765
D+DI SPF+ H+
Sbjct: 645 DDEDIRDSPFIAHI 658
Score = 76.3 bits (186), Expect = 1e-13
Identities = 78/272 (28%), Positives = 116/272 (42%), Gaps = 16/272 (5%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNAD--PGMVHATGEGL--SRAV 168
G V++ P E G + V V + + I SPF + D P V A G GL + +
Sbjct: 624 GSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCI 683
Query: 169 VDKKAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINIT 339
VDK A F ++ AG G L + ++ G + +YV T P + I I+
Sbjct: 684 VDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGNGTFRCSYVPTKPIKHTIIIS 743
Query: 340 YGGNFHIVGSPFTA-VCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
+GG ++ SPF V EG S+ E+V
Sbjct: 744 WGG-VNVPKSPFRVNVGEG--------------------------------SHPERVKVY 770
Query: 517 GLGLKQARL--NSVNSFFVDASQAGYGILLVGI---AGPVRPCEEVV---VRHVGNNQFT 672
G G+++ L N F VD S+AG G + +GI G V P E + + N+ FT
Sbjct: 771 GPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFT 830
Query: 673 VDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
V Y +G + IMV + +++IP SPF + VD
Sbjct: 831 VKYTPPGAGRYTIMVLFANQEIPASPFHIKVD 862
Score = 74.3 bits (181), Expect = 4e-13
Identities = 71/261 (27%), Positives = 99/261 (37%), Gaps = 6/261 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P E G + + + + I GSPF+ + DP V A+G GL R V +
Sbjct: 1115 GSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPV-FDPSKVRASGPGLERGKVGEA 1173
Query: 181 AHFFVNTTNAGSGSLNVAI--DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGN 351
A F V+ + AG L + I D K + H +G Y TY PG Y I I YGG
Sbjct: 1174 ATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGG- 1232
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H V T V H Q ++ S KV G+
Sbjct: 1233 -HPVPKFPTRV-------------HVQPAVDTS---------------GVKVSGPGVEPH 1263
Query: 532 QARLNSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
F VDA + G + + P + V G+ + V Y E G
Sbjct: 1264 GVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGV 1323
Query: 703 HIIMVRWGDKDIPGSPFMVHV 765
H++ V + + +P SPF V V
Sbjct: 1324 HLVEVLYDEVAVPKSPFRVGV 1344
Score = 70.9 bits (172), Expect = 4e-12
Identities = 68/259 (26%), Positives = 105/259 (40%), Gaps = 4/259 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G + ++ P G ++V + I SPF + V A V A G GL V K
Sbjct: 531 GVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSP-EAGVQKVRAWGPGLETGQVGKS 589
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
A F V G+L +I+GPS+ + C + +G + Y T PG Y +++
Sbjct: 590 ADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHV------- 642
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
+C+ D+ H I + C + +KV G GL+
Sbjct: 643 --------ICDDEDIRDSPFIAH----ILPAPPDC----------FPDKVKAFGPGLEPT 680
Query: 538 R--LNSVNSFFVDASQAGYGILLVGIAGPVRPCE-EVVVRHVGNNQFTVDYVVKESGTHI 708
++ F +DA AG G L + A C ++ V GN F YV + H
Sbjct: 681 GCIVDKPAEFTIDARAAGKGDLKL-YAQDADGCPIDIKVIPNGNGTFRCSYVPTKPIKHT 739
Query: 709 IMVRWGDKDIPGSPFMVHV 765
I++ WG ++P SPF V+V
Sbjct: 740 IIISWGGVNVPKSPFRVNV 758
Score = 67.4 bits (163), Expect = 5e-11
Identities = 68/271 (25%), Positives = 113/271 (41%), Gaps = 15/271 (5%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLS---- 159
G Y V + P SG + + ++ I SPFRI P G + V G GL
Sbjct: 1596 GTYAVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLG 1655
Query: 160 -RAVVDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
R + ++ V+ AG G + + P ++++++ E +G ++ Y A PG Y+
Sbjct: 1656 PRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYV 1715
Query: 328 INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
I I +GG HI SPF + + E + Q+ + R + T +A +
Sbjct: 1716 ITIRFGGE-HIPNSPFHVLACDPLPHEEEPSEVPQLRQPYAPPRP----GARPTHWATEE 1770
Query: 508 ICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---FTV 675
+ ++ L N A Q G + G VR P + ++ +N+ TV
Sbjct: 1771 PVVPVEPMESMLRPFNLVIPFAVQKGE------LTGEVRMPSGKTARPNITDNKDGTITV 1824
Query: 676 DYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
Y E G H + +++ IPGSP +VD
Sbjct: 1825 RYAPTEKGLHQMGIKYDGNHIPGSPLQFYVD 1855
Score = 67.0 bits (162), Expect = 6e-11
Identities = 64/258 (24%), Positives = 96/258 (37%), Gaps = 3/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P G + + V + K I GSPF + D M S+ V
Sbjct: 1912 GTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI---TGDDSM------RTSQLNVGTS 1962
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAP---GNYIINITYGGN 351
+ T + L +I PS C ++ P G +++++ G
Sbjct: 1963 TDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGK 2022
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H+ SPF + ++ GD A KV G GL
Sbjct: 2023 -HVTNSPFKILVGPSEIGD-----------------------------ASKVRVWGKGLS 2052
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+ V F VD AGYG L + I GP + ++ + + V Y E GT+II
Sbjct: 2053 EGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKV--DINCEDMEDGTCKVTYCPTEPGTYII 2110
Query: 712 MVRWGDKDIPGSPFMVHV 765
+++ DK +PGSPF V V
Sbjct: 2111 NIKFADKHVPGSPFTVKV 2128
Score = 65.9 bits (159), Expect = 1e-10
Identities = 70/262 (26%), Positives = 106/262 (40%), Gaps = 7/262 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G GV + +E G + V ++ N + I SPF +PV + D + T + V++
Sbjct: 2367 GSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQP 2426
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
A F V N G ++ + PS C+ +E + + ++ G + I++ + G
Sbjct: 2427 ASFAVQ-LNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNG- 2484
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
HI GSPF V + SQ A D VS Y G GL+
Sbjct: 2485 AHIPGSPF----------KIRVGEQSQ----AGDPGLVSAY--------------GPGLE 2516
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
+ F V+ AG G L V I GP + C E HV V Y G
Sbjct: 2517 GGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHV------VTYTPMAPGN 2570
Query: 703 HIIMVRW-GDKDIPGSPFMVHV 765
++I +++ G + I GSPF V
Sbjct: 2571 YLIAIKYGGPQHIVGSPFKAKV 2592
Score = 63.2 bits (152), Expect = 9e-10
Identities = 72/262 (27%), Positives = 105/262 (40%), Gaps = 11/262 (4%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
+ VK+TP +G + + V + I SPF I V + D V A G GL+R V+ K
Sbjct: 829 FTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSH-DASKVKAEGPGLNRTGVEVGKP 887
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMN-----CHETEEGYEFTYVATAPGNYIINITYG 345
HF V T AG L+V G +K + + Y Y A GN + +TYG
Sbjct: 888 THFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYG 947
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G+ + SPF V +++ K+ QGL
Sbjct: 948 GD-PVPKSPFV------------VNVAPPLDL-------------------SKIKVQGLN 975
Query: 526 LKQARLNSVNSFFVDASQA-GYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKE 693
K A + +F V+ A G G L V + P R PC+ + G V Y+ E
Sbjct: 976 SKVA-VGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCK--LEPGGGAEAQAVRYMPPE 1032
Query: 694 SGTHIIMVRWGDKDIPGSPFMV 759
G + + + + +PGSPF V
Sbjct: 1033 EGPYKVDITYDGHPVPGSPFAV 1054
Score = 54.7 bits (130), Expect = 3e-07
Identities = 61/263 (23%), Positives = 103/263 (39%), Gaps = 8/263 (3%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y + ++P GT+ + ++ P+ P R+ V D V +G G+ V ++
Sbjct: 1210 GTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLRE 1268
Query: 181 A--HFFVNT---TNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINI 336
F V+ T G + + PS + + T+ G Y Y A G +++ +
Sbjct: 1269 VTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEV 1328
Query: 337 TYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
Y + SPF + G TE ++V
Sbjct: 1329 LYD-EVAVPKSPF-------RVGVTEGCDPTRVR------------------------AF 1356
Query: 517 GLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
G GL+ +N N F V+ AG G L + I GP ++ + + TV+Y+
Sbjct: 1357 GPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEA--KMSCKDNKDGSCTVEYIPFTP 1414
Query: 697 GTHIIMVRWGDKDIPGSPFMVHV 765
G + + + +G + IPGSPF V V
Sbjct: 1415 GDYDVNITFGGRPIPGSPFRVPV 1437
Score = 51.6 bits (122), Expect = 3e-06
Identities = 59/272 (21%), Positives = 105/272 (38%), Gaps = 17/272 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVV--D 174
G + + P + H + + + SPFR+ VG + P V G G+ + + +
Sbjct: 724 GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE-GSHPERVKVYGPGVEKTGLKAN 782
Query: 175 KKAHFFVNTTNAGSGSLNVAID------GPSKVNMN---CHETEEGYEFTYVATAPGNYI 327
+ +F V+ + AG G +++ I GP++ +++ + + Y G Y
Sbjct: 783 EPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYT 842
Query: 328 INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
I + + N I SPF ++++ S A KV
Sbjct: 843 IMVLFA-NQEIPASPF------------------HIKVDPSHD-------------ASKV 870
Query: 508 ICQGLGLKQA--RLNSVNSFFVDASQAGYGILLVGIAGPVRPCE----EVVVRHVGNNQF 669
+G GL + + F V AG L V AG + E++ H + +
Sbjct: 871 KAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNH--DYSY 928
Query: 670 TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
TV Y + G + V +G +P SPF+V+V
Sbjct: 929 TVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNV 960
Score = 38.5 bits (88), Expect = 0.024
Identities = 51/256 (19%), Positives = 93/256 (36%), Gaps = 1/256 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P E GT+++ ++ K + GSPF + V TGEG + + ++
Sbjct: 2094 GTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKV------------TGEGRMKESITRR 2141
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFHI 360
T + LN+ I G ++ E + T+ + H
Sbjct: 2142 RQAPSIATIGSTCDLNLKIPGNWFQMVSAQER-----------------LTRTFTRSSHT 2184
Query: 361 VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
T+ G+T+ E V +E S + + + L + R
Sbjct: 2185 YTRTERTEISKTRGGETKPE----VRVEESTQVGGDPFPAVFGDF----------LGRER 2230
Query: 541 LNSVNSFF-VDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
L S S +A + + P E + ++ ++V +V +E G H + V
Sbjct: 2231 LGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAV 2290
Query: 718 RWGDKDIPGSPFMVHV 765
++ + +PGSPF V
Sbjct: 2291 KYRGQHVPGSPFQFTV 2306
Score = 37.7 bits (86), Expect = 0.041
Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Frame = +1
Query: 559 FFVDASQAGYGILLVGIAGPVRPCEE--VVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
F V AG G +LV I P EE VV + + + V YV K +G H + V + +
Sbjct: 298 FTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQ 357
Query: 733 DIPGSPFMVHV 765
+I SPF V+V
Sbjct: 358 NIERSPFEVNV 368
>sp|P21333|FLNA_HUMAN Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding
protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle
filamin)
Length = 2647
Score = 227 bits (578), Expect = 4e-59
Identities = 117/260 (45%), Positives = 168/260 (64%), Gaps = 6/260 (2%)
Frame = +1
Query: 4 QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGH--YNADPGMVHATGEGLSRAVVDK 177
+Y V+F pre+G +++ V+ N I GSPF+I VG + DPG+V A G GL V
Sbjct: 2387 KYAVRFIpreNGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGN 2446
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
A F VNT+NAG+G+L+V IDGPSKV M+C E EGY TY APG+Y+I+I YGG +H
Sbjct: 2447 PAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYH 2506
Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDK-RCVSQYAEKTTSYAE--KVICQGLG 525
I GSPF A G + + + + S V +++ K C Q+ A+ KV+ +GLG
Sbjct: 2507 IGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLG 2566
Query: 526 LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
L +A + +SF VD S+AG +LLVG+ GP PCEE++V+HVG+ ++V Y++K+ G +
Sbjct: 2567 LSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEY 2626
Query: 706 IIMVRWGDKDIPGSPFMVHV 765
++V+WG + IPGSP+ V V
Sbjct: 2627 TLVVKWGHEHIPGSPYRVVV 2646
Score = 132 bits (331), Expect = 2e-30
Identities = 88/258 (34%), Positives = 121/258 (46%), Gaps = 3/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y V++TP E G H V V + P+ SPF++PV DP V G G+ +K
Sbjct: 1315 GMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTE-GCDPSRVRVHGPGIQSGTTNKP 1373
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
F V T AG+G L +A++GPS+ M+C + ++G Y+ G Y +N+TYGG+
Sbjct: 1374 NKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGH-Q 1432
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK-- 531
+ GSPF +V H + A KV C G GL
Sbjct: 1433 VPGSPF------------KVPVHDVTD-------------------ASKVKCSGPGLSPG 1461
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
R N SF VD S+AG L V + GP E V V + TV+YV G + I
Sbjct: 1462 MVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSI 1521
Query: 712 MVRWGDKDIPGSPFMVHV 765
V +GD+++P SPF V V
Sbjct: 1522 SVLYGDEEVPRSPFKVKV 1539
Score = 109 bits (272), Expect = 1e-23
Identities = 72/257 (28%), Positives = 118/257 (45%), Gaps = 2/257 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDK 177
G G+ F P+E+G H+V V+ N + + SP + + D V +G+GL +
Sbjct: 2005 GHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFE 2064
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
A F ++T +AG G L+++I+GPSKV++N + E+G TY T PGNYIINI +
Sbjct: 2065 PAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQ- 2123
Query: 355 HIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQ 534
H+ GSPF+ TG+ V++ A V + + L LK
Sbjct: 2124 HVPGSPFSV----KVTGEGRVKESITRRRRAPSVANVGSHCD-------------LSLKI 2166
Query: 535 ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
++ + + + P E + N+ + + +V E GTH +
Sbjct: 2167 PEISIQD-------------MTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVS 2213
Query: 715 VRWGDKDIPGSPFMVHV 765
V++ + +PGSPF V
Sbjct: 2214 VKYKGQHVPGSPFQFTV 2230
Score = 105 bits (263), Expect = 1e-22
Identities = 75/253 (29%), Positives = 112/253 (44%), Gaps = 1/253 (0%)
Frame = +1
Query: 13 VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFF 192
V+F pre G + V V + P+ GSPF + P V A G GL A F
Sbjct: 1031 VRFLpreEGPYEVEVTYDGVPVPGSPFPLEAVA-PTKPSKVKAFGPGLQGGSAGSPARFT 1089
Query: 193 VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGS 369
++T AG+G L + ++GP + + C + +G +YV T PG+Y INI + + HI GS
Sbjct: 1090 IDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILF-ADTHIPGS 1148
Query: 370 PFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNS 549
PF A H +AS KV C G GL++A
Sbjct: 1149 PFKA--------------HVVPCFDAS-----------------KVKCSGPGLERATAGE 1177
Query: 550 VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGD 729
V F VD S AG L + I EV ++ G+ T+ Y+ G + + +++G
Sbjct: 1178 VGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGG 1237
Query: 730 KDIPGSPFMVHVD 768
+ +P P + V+
Sbjct: 1238 QPVPNFPSKLQVE 1250
Score = 100 bits (250), Expect = 4e-21
Identities = 69/254 (27%), Positives = 114/254 (44%), Gaps = 1/254 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V++ P E+G H + + + I GSP + V + N G V A G GL+ VV+K
Sbjct: 1826 GTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNC--GHVTAYGPGLTHGVVNKP 1883
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
A F VNT +AG G L++AI+GPSK ++C + ++G +Y+ PG+Y I + Y H
Sbjct: 1884 ATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQ-H 1942
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
+ GSPFTA TGD + +
Sbjct: 1943 VPGSPFTA----RVTGD-----------------------------------DSMRMSHL 1963
Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
++ S ++ S+ +L + P E +++ + N + +V KE+G H++ V
Sbjct: 1964 KVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHV 2023
Query: 718 RWGDKDIPGSPFMV 759
+ + + SP V
Sbjct: 2024 KKNGQHVASSPIPV 2037
Score = 98.6 bits (244), Expect = 2e-20
Identities = 72/255 (28%), Positives = 115/255 (45%), Gaps = 2/255 (0%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
Y ++F P E GTH V V+ + + GSPF+ VG V A G GL RA A
Sbjct: 2198 YCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPA 2257
Query: 184 HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
F + T AG+G L +A++GPSK ++ + ++G YV PG+Y +++ + HI
Sbjct: 2258 EFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEE-HI 2316
Query: 361 VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
SPF V + +GD A ++ L +
Sbjct: 2317 PDSPF-VVPVASPSGD-----------------------------ARRLTVSSLQESGLK 2346
Query: 541 LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
+N SF V + A G + + P EE V + +++ V ++ +E+G ++I V+
Sbjct: 2347 VNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGVYLIDVK 2405
Query: 721 WGDKDIPGSPFMVHV 765
+ IPGSPF + V
Sbjct: 2406 FNGTHIPGSPFKIRV 2420
Score = 91.3 bits (225), Expect = 3e-18
Identities = 94/325 (28%), Positives = 126/325 (38%), Gaps = 72/325 (22%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK-- 180
Y + P G H V V PI SP+ + VG +P A G GL V K
Sbjct: 442 YRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA-CNPSACRAVGRGLQPKGVRVKET 500
Query: 181 AHFFVNTTNAGSGSLNVAIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
A F V T AGSG L V + GP + + + +G Y F Y PG YI+ IT+GG
Sbjct: 501 ADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQ- 559
Query: 355 HIVGSPFTAVCEGTKTGDTE----------------------------------VEQHSQ 432
+I SPF V GT+ G+ + VE SQ
Sbjct: 560 NIGRSPF-EVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQ 618
Query: 433 VEIEASDK---RC-VSQYAEKTTSYAEKVIC----------------------------Q 516
+IE DK C V + ++ YA V+C +
Sbjct: 619 AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKAR 678
Query: 517 GLGLKQ--ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVK 690
G GL++ +N F VDA G L V + E +V+ GN ++ YV +
Sbjct: 679 GPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPR 738
Query: 691 ESGTHIIMVRWGDKDIPGSPFMVHV 765
+ H MV WG IP SPF V+V
Sbjct: 739 KPVKHTAMVSWGGVSIPNSPFRVNV 763
Score = 75.5 bits (184), Expect = 2e-13
Identities = 70/272 (25%), Positives = 107/272 (39%), Gaps = 7/272 (2%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGL--SRAVVDKK 180
+ V + P +GTH V V + I SPF + V D V A G GL S + +K
Sbjct: 342 FSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKT 401
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-----YEFTYVATAPGNYIINITYG 345
+F + T AG+G + V I P E Y +Y T G + +++T+
Sbjct: 402 TYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFA 461
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G I SP+T + A + + +GL
Sbjct: 462 G-VPIPRSPYTVT-----------------------------VGQACNPSACRAVGRGLQ 491
Query: 526 LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
K R+ F V AG G L V + GP + E V + +G+ + +Y GT+
Sbjct: 492 PKGVRVKETADFKVYTKGAGSGELKVTVKGP-KGEERVKQKDLGDGVYGFEYYPMVPGTY 550
Query: 706 IIMVRWGDKDIPGSPFMVHVD*EIIILTACSN 801
I+ + WG ++I SPF E+ + T C N
Sbjct: 551 IVTITWGGQNIGRSPF------EVKVGTECGN 576
Score = 72.0 bits (175), Expect = 2e-12
Identities = 70/262 (26%), Positives = 109/262 (41%), Gaps = 7/262 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G GV + +E G + V V+ N++ I SPF +PV + D + + S V++
Sbjct: 2291 GSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQP 2350
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
A F V + N G+++ + PS C+ TE + Y ++ G Y+I++ + G
Sbjct: 2351 ASFAV-SLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGVYLIDVKFNGT 2409
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
HI GSPF + G+ D VS Y G GL+
Sbjct: 2410 -HIPGSPFK-----IRVGEPG---------HGGDPGLVSAY--------------GAGLE 2440
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
+ F V+ S AG G L V I GP + C+E + V Y G+
Sbjct: 2441 GGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQEC------PEGYRVTYTPMAPGS 2494
Query: 703 HIIMVRWGDK-DIPGSPFMVHV 765
++I +++G I GSPF V
Sbjct: 2495 YLISIKYGGPYHIGGSPFKAKV 2516
Score = 71.2 bits (173), Expect = 3e-12
Identities = 69/273 (25%), Positives = 119/273 (43%), Gaps = 17/273 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLSRAV- 168
G Y V + P +G + + ++ I SP+R+ P G + V G GL +
Sbjct: 1602 GTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIG 1661
Query: 169 ----VDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
+ ++ V+T AG G + + P S+V+++ E E+G ++ Y A PG Y+
Sbjct: 1662 PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYV 1721
Query: 328 INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
I + +GG H+ SPF GD Q + + + +Q ++T + +
Sbjct: 1722 ICVRFGGE-HVPNSPFQVTA---LAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPL 1777
Query: 508 I-CQGLGLKQAR-LNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---F 669
+ GL + R + V F + + I G VR P +V + +N+
Sbjct: 1778 VGVNGLDVTSLRPFDLVIPFTIKKGE---------ITGEVRMPSGKVAQPTITDNKDGTV 1828
Query: 670 TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
TV Y E+G H + +R+ + IPGSP +VD
Sbjct: 1829 TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 1861
Score = 70.9 bits (172), Expect = 4e-12
Identities = 72/269 (26%), Positives = 110/269 (40%), Gaps = 13/269 (4%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNAD--PGMVHATGEGLSRA--V 168
G V++ P+E+G + V V N + I SPF + D P V A G GL +
Sbjct: 629 GSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVA 688
Query: 169 VDKKAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINIT 339
V+K A F V+ + G L V + + + G Y +YV P + ++
Sbjct: 689 VNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVS 748
Query: 340 YGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQG 519
+GG I SPF +V + A + K Y V G
Sbjct: 749 WGG-VSIPNSPF------------------RVNVGAGS------HPNKVKVYGPGVAKTG 783
Query: 520 LGLKQARLNSVNSFFVDASQAGYGILLVGIA---GPVRPCEEVV---VRHVGNNQFTVDY 681
L + + F VD ++AG G + +GI G V P E + + N+ FTV Y
Sbjct: 784 L-----KAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKY 838
Query: 682 VVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
+ +G++ IMV + D+ P SP V V+
Sbjct: 839 TPRGAGSYTIMVLFADQATPTSPIRVKVE 867
Score = 68.6 bits (166), Expect = 2e-11
Identities = 71/261 (27%), Positives = 108/261 (41%), Gaps = 12/261 (4%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
+ VK+TPR +G++ + V + SP R+ V + D V A G GLSR V+ K
Sbjct: 834 FTVKYTPRGAGSYTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKP 892
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSK------VNMNCHETEEGYEFTYVATAPGNYIINITY 342
HF VN AG G L+V G +K V++ H + Y Y G +N+TY
Sbjct: 893 THFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHH-DNTYTVKYTPVQQGPVGVNVTY 951
Query: 343 GGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGL 522
GG+ I SPF+ A + K+ GL
Sbjct: 952 GGD-PIPKSPFSV-------------------------------AVSPSLDLSKIKVSGL 979
Query: 523 GLKQARLNSVNSFFVDASQAG----YGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVK 690
G ++ + F V + AG +VG +G PC+ V +G + V ++ +
Sbjct: 980 G-EKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCK--VEPGLGADNSVVRFLPR 1036
Query: 691 ESGTHIIMVRWGDKDIPGSPF 753
E G + + V + +PGSPF
Sbjct: 1037 EEGPYEVEVTYDGVPVPGSPF 1057
Score = 68.6 bits (166), Expect = 2e-11
Identities = 67/263 (25%), Positives = 105/263 (39%), Gaps = 8/263 (3%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P E G + + + I GSPF+ V D V +G GL RA +
Sbjct: 1120 GTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPC-FDASKVKCSGPGLERATAGEV 1178
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGGN 351
F V+ ++AGS L + I + + + + G + TY+ PG Y + I YGG
Sbjct: 1179 GQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQ 1238
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
+ P S++++E A T+ V C G G++
Sbjct: 1239 -PVPNFP------------------SKLQVEP---------AVDTSG----VQCYGPGIE 1266
Query: 532 QARL--NSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
+ + F VDA +Q G + +A P E V+ G+ + V+Y E
Sbjct: 1267 GQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEE 1326
Query: 697 GTHIIMVRWGDKDIPGSPFMVHV 765
G H + V + +P SPF V V
Sbjct: 1327 GLHSVDVTYDGSPVPSSPFQVPV 1349
Score = 65.5 bits (158), Expect = 2e-10
Identities = 67/258 (25%), Positives = 100/258 (38%), Gaps = 5/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P G + + V + + SPF++ V + D V A+G GL+ V
Sbjct: 1505 GTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTH-DASKVKASGPGLNTTGVPAS 1563
Query: 181 --AHFFVNTTNAGSGSLNVAIDGPSKVNMNCH--ETEEG-YEFTYVATAPGNYIINITYG 345
F ++ +AG G L V I P H + +G Y YV G Y I I YG
Sbjct: 1564 LPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYG 1623
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G+ I SP+ TGD +C T S + G+G
Sbjct: 1624 GD-EIPFSPYRV--RAVPTGDAS--------------KCTV-----TVSIGGHGLGAGIG 1661
Query: 526 LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
++ VD AG G + + P +V V + F + Y + G +
Sbjct: 1662 -PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKY 1720
Query: 706 IIMVRWGDKDIPGSPFMV 759
+I VR+G + +P SPF V
Sbjct: 1721 VICVRFGGEHVPNSPFQV 1738
Score = 58.5 bits (140), Expect = 2e-08
Identities = 67/272 (24%), Positives = 107/272 (39%), Gaps = 17/272 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y + PR+ H V I SPFR+ VG + P V G G+++ + K
Sbjct: 729 GTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGA-GSHPNKVKVYGPGVAKTGL--K 785
Query: 181 AH----FFVNTTNAGSGSLNVAID------GPSKVNMN---CHETEEGYEFTYVATAPGN 321
AH F V+ AG G +++ I GP++ +++ + + Y G+
Sbjct: 786 AHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGS 845
Query: 322 YIINITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAE 501
Y I + + +P + + +V++E S A
Sbjct: 846 YTIMVLFADQ----ATPTSPI---------------RVKVEPSHD-------------AS 873
Query: 502 KVICQGLGLKQA--RLNSVNSFFVDASQAGYGILLVGIAGPVR--PCEEVVVRHVGNNQF 669
KV +G GL + L F V+A AG G L V +G + +V + +N +
Sbjct: 874 KVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTY 933
Query: 670 TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
TV Y + G + V +G IP SPF V V
Sbjct: 934 TVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAV 965
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Frame = +1
Query: 559 FFVDASQAGYGILLVGIAGPVRPCEE--VVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
F V+ AG G +LV + P EE V + N F+V YV + +GTH + V + +
Sbjct: 304 FTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQ 363
Query: 733 DIPGSPFMVHVD 768
I SPF V+VD
Sbjct: 364 HIAKSPFEVYVD 375
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/87 (29%), Positives = 42/87 (48%)
Frame = +1
Query: 505 VICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYV 684
V G GL +N +F V+ AG G L + I GP + E+ + +V Y+
Sbjct: 1868 VTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYL 1925
Query: 685 VKESGTHIIMVRWGDKDIPGSPFMVHV 765
G + I+V++ ++ +PGSPF V
Sbjct: 1926 PVLPGDYSILVKYNEQHVPGSPFTARV 1952
>sp|Q8BTM8|FLNA_MOUSE Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding
protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle
filamin)
Length = 2647
Score = 227 bits (578), Expect = 4e-59
Identities = 116/260 (44%), Positives = 170/260 (65%), Gaps = 6/260 (2%)
Frame = +1
Query: 4 QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGH--YNADPGMVHATGEGLSRAVVDK 177
+Y V+F pre+G +++ V+ N I GSPF+I VG + DPG+V A G GL V
Sbjct: 2387 KYAVRFIpreNGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGS 2446
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
A F VNT+NAG+G+L+V IDGPSKV M+C E EGY TY APG+Y+I+I YGG +H
Sbjct: 2447 PAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYH 2506
Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDK-RCVSQYAEKTTSYAE--KVICQGLG 525
I GSPF A G + + + + S V +++ K V Q+A A+ KV+ +GLG
Sbjct: 2507 IGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKVATVPQHATSGPGPADVSKVVAKGLG 2566
Query: 526 LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
L +A + ++F VD S+AG +LLVG+ GP PCEE++V+H+G+ ++V Y++K+ G +
Sbjct: 2567 LSKAYVGQKSNFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHMGSRLYSVSYLLKDKGEY 2626
Query: 706 IIMVRWGDKDIPGSPFMVHV 765
++V+WGD+ IPGSP+ + V
Sbjct: 2627 TLVVKWGDEHIPGSPYRIMV 2646
Score = 131 bits (329), Expect = 3e-30
Identities = 87/258 (33%), Positives = 122/258 (47%), Gaps = 3/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y V++TP E G H V V + P+ SPF++PV DP V G G+ +K
Sbjct: 1315 GTYKVEYTPYEEGVHSVDVTYDGSPVPSSPFQVPVTE-GCDPSRVRVHGPGIQSGTTNKP 1373
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
F V T AG+G L +A++GPS+ M+C + ++G Y+ G Y +N+TYGG+
Sbjct: 1374 NKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGH-Q 1432
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK-- 531
+ GSPF +V H + A KV C G GL
Sbjct: 1433 VPGSPF------------KVPVHDVTD-------------------ASKVKCSGPGLSPG 1461
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
R N SF VD S+AG L V + GP E V V + TV+YV G++ I
Sbjct: 1462 MVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGSYSI 1521
Query: 712 MVRWGDKDIPGSPFMVHV 765
V +G++++P SPF V V
Sbjct: 1522 SVLYGEEEVPRSPFKVKV 1539
Score = 106 bits (265), Expect = 7e-23
Identities = 70/257 (27%), Positives = 117/257 (45%), Gaps = 2/257 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDK 177
G G+ F P+E+G H+V V+ N + + SP + + D V +G+GL +
Sbjct: 2005 GHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFE 2064
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
A F ++T +AG G L+++I+GPSKV++N + E+G TY T PGNYIINI +
Sbjct: 2065 PAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQ- 2123
Query: 355 HIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQ 534
H+ GSPF+ TG+ V++ A + + + L LK
Sbjct: 2124 HVPGSPFSV----KVTGEGRVKESITRRRRAPSVANIGSHCD-------------LSLKI 2166
Query: 535 ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
++ + + + P E + N+ + + +V E G H +
Sbjct: 2167 PEISIQD-------------MTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVS 2213
Query: 715 VRWGDKDIPGSPFMVHV 765
V++ + +PGSPF V
Sbjct: 2214 VKYKGQHVPGSPFQFTV 2230
Score = 106 bits (264), Expect = 9e-23
Identities = 75/253 (29%), Positives = 112/253 (44%), Gaps = 1/253 (0%)
Frame = +1
Query: 13 VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFF 192
V+F pre G + V V + P+ GSPF + P V A G GL A F
Sbjct: 1031 VRFVpreEGPYEVEVTYDGVPVPGSPFPLEAVA-PTKPSKVKAFGPGLQGGNAGSPARFT 1089
Query: 193 VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGS 369
++T AG+G L + ++GP + + C + +G +YV T PG+Y INI + + HI GS
Sbjct: 1090 IDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILF-ADTHIPGS 1148
Query: 370 PFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNS 549
PF A H +AS KV C G GL++A
Sbjct: 1149 PFKA--------------HVAPCFDAS-----------------KVKCSGPGLERATAGE 1177
Query: 550 VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGD 729
V F VD S AG L + I EV ++ G+ T+ Y+ G + + +++G
Sbjct: 1178 VGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGG 1237
Query: 730 KDIPGSPFMVHVD 768
+ +P P + V+
Sbjct: 1238 QPVPNFPSKLQVE 1250
Score = 101 bits (252), Expect = 2e-21
Identities = 69/254 (27%), Positives = 115/254 (45%), Gaps = 1/254 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V+++P E+G H + + + I GSP + V + N G + A G GL+ VV+K
Sbjct: 1826 GTVTVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNC--GHITAYGPGLTHGVVNKP 1883
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
A F VNT +AG G L++AI+GPSK ++C + ++G +Y+ PG+Y I + Y H
Sbjct: 1884 ATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNDQ-H 1942
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I GSPFTA TGD + +
Sbjct: 1943 IPGSPFTA----RVTGD-----------------------------------DSMRMSHL 1963
Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
++ S ++ S+ +L + P E +++ + N + +V KE+G H++ V
Sbjct: 1964 KVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHV 2023
Query: 718 RWGDKDIPGSPFMV 759
+ + + SP V
Sbjct: 2024 KKNGQHVASSPIPV 2037
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/255 (27%), Positives = 114/255 (44%), Gaps = 2/255 (0%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
Y ++F P E G H V V+ + + GSPF+ VG V A G GL RA A
Sbjct: 2198 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPA 2257
Query: 184 HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
F + T AG+G L +A++GPSK ++ + ++G YV PG+Y +++ + HI
Sbjct: 2258 EFGIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEE-HI 2316
Query: 361 VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
SPF V + +GD A ++ L +
Sbjct: 2317 PDSPF-VVPVASPSGD-----------------------------ARRLTVSSLQESGLK 2346
Query: 541 LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
+N SF V + A G + + P EE V + +++ V ++ +E+G ++I V+
Sbjct: 2347 VNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGIYLIDVK 2405
Query: 721 WGDKDIPGSPFMVHV 765
+ IPGSPF + V
Sbjct: 2406 FNGTHIPGSPFKIRV 2420
Score = 92.8 bits (229), Expect = 1e-18
Identities = 95/325 (29%), Positives = 126/325 (38%), Gaps = 72/325 (22%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK-- 180
Y + P G H V V PI SP+ + VG +P A G GL V K
Sbjct: 442 YRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA-CNPAACRAIGRGLQPKGVRVKET 500
Query: 181 AHFFVNTTNAGSGSLNVAIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
A F V T AGSG L V + GP + + + +G Y F Y T PG Y + IT+GG
Sbjct: 501 ADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQ- 559
Query: 355 HIVGSPFTAVCEGTKTGDTE----------------------------------VEQHSQ 432
+I SPF V GT+ G+ + VE SQ
Sbjct: 560 NIGRSPF-EVKVGTECGNQKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQ 618
Query: 433 VEIEASDK---RC-VSQYAEKTTSYAEKVIC----------------------------Q 516
+IE DK C V + ++ YA V+C +
Sbjct: 619 AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678
Query: 517 GLGLKQ--ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVK 690
G GL++ +N F VDA AG L V + E V+ GN ++ YV +
Sbjct: 679 GPGLEKTGVAVNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPR 738
Query: 691 ESGTHIIMVRWGDKDIPGSPFMVHV 765
+ H MV WG IP SPF V+V
Sbjct: 739 KPVKHTAMVSWGGVSIPNSPFRVNV 763
Score = 73.6 bits (179), Expect = 7e-13
Identities = 70/272 (25%), Positives = 106/272 (38%), Gaps = 7/272 (2%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGL--SRAVVDKK 180
+ V + P +GTH V V + I SPF + V D V A G GL S + +K
Sbjct: 342 FSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKT 401
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-----YEFTYVATAPGNYIINITYG 345
+F + T AG G + V I P+ E Y +Y T G + +++T+
Sbjct: 402 TYFEIFTAGAGMGEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFA 461
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G I SP+T + A + I +GL
Sbjct: 462 G-VPIPRSPYTVT-----------------------------VGQACNPAACRAIGRGLQ 491
Query: 526 LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
K R+ F V AG G L V + GP + E V + +G+ + +Y GT+
Sbjct: 492 PKGVRVKETADFKVYTKGAGSGELKVTVKGP-KGEERVKQKDLGDGVYGFEYYPTIPGTY 550
Query: 706 IIMVRWGDKDIPGSPFMVHVD*EIIILTACSN 801
+ + WG ++I SPF E+ + T C N
Sbjct: 551 TVTITWGGQNIGRSPF------EVKVGTECGN 576
Score = 73.6 bits (179), Expect = 7e-13
Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 7/262 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G GV + +E G + V V+ N++ I SPF +PV + D + + S V++
Sbjct: 2291 GSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQP 2350
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
A F V + N G+++ + PS C+ TE + Y ++ G Y+I++ + G
Sbjct: 2351 ASFAV-SLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGIYLIDVKFNGT 2409
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
HI GSPF + G+ D VS Y G GL+
Sbjct: 2410 -HIPGSPFK-----IRVGEPG---------HGGDPGLVSAY--------------GAGLE 2440
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
S F V+ S AG G L V I GP + C+E + V Y G+
Sbjct: 2441 GGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQEC------PEGYRVTYTPMAPGS 2494
Query: 703 HIIMVRWGDK-DIPGSPFMVHV 765
++I +++G I GSPF V
Sbjct: 2495 YLISIKYGGPYHIGGSPFKAKV 2516
Score = 72.0 bits (175), Expect = 2e-12
Identities = 73/269 (27%), Positives = 111/269 (41%), Gaps = 13/269 (4%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNAD--PGMVHATGEGLSRA--V 168
G V++ P+E+G + V V N + I SPF + D P V A G GL +
Sbjct: 629 GSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVA 688
Query: 169 VDKKAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINIT 339
V+K A F V+ +AG L V + ++ + G Y +YV P + ++
Sbjct: 689 VNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPRKPVKHTAMVS 748
Query: 340 YGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQG 519
+GG I SPF +V + A + K Y V G
Sbjct: 749 WGG-VSIPNSPF------------------RVNVGAGS------HPNKVKVYGPGVAKTG 783
Query: 520 LGLKQARLNSVNSFFVDASQAGYGILLVGIA---GPVRPCEEVV---VRHVGNNQFTVDY 681
L + + F VD ++AG G + +GI G V P E + + N+ FTV Y
Sbjct: 784 L-----KAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKY 838
Query: 682 VVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
+G++ IMV + D+ P SP V V+
Sbjct: 839 TPCGAGSYTIMVLFADQATPTSPIRVKVE 867
Score = 70.1 bits (170), Expect = 7e-12
Identities = 68/258 (26%), Positives = 103/258 (39%), Gaps = 5/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P G++ + V ++ + SPF++ V + D V A+G GL+ V
Sbjct: 1505 GTQTVNYVPSREGSYSISVLYGEEEVPRSPFKVKVLPTH-DASKVKASGPGLNTTGVPAS 1563
Query: 181 --AHFFVNTTNAGSGSLNVAIDGPSKVNMNCH--ETEEG-YEFTYVATAPGNYIINITYG 345
F ++ +AG G L V I P H + +G Y YV PG Y I I YG
Sbjct: 1564 LPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVPGRYTILIKYG 1623
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G+ I SP+ TGD +C T S + G+G
Sbjct: 1624 GD-EIPFSPYRV--RAVPTGDAS--------------KCTV-----TVSIGGHGLGAGIG 1661
Query: 526 LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
++ VD AG G + + P +V V + F + Y + G +
Sbjct: 1662 -PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKY 1720
Query: 706 IIMVRWGDKDIPGSPFMV 759
+I VR+G + +P SPF V
Sbjct: 1721 VICVRFGGEHVPNSPFQV 1738
Score = 69.3 bits (168), Expect = 1e-11
Identities = 66/263 (25%), Positives = 105/263 (39%), Gaps = 8/263 (3%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P E G + + + I GSPF+ V D V +G GL RA +
Sbjct: 1120 GTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVAPC-FDASKVKCSGPGLERATAGEV 1178
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGGN 351
F V+ ++AGS L + I + + + + G + TY+ PG Y + I YGG
Sbjct: 1179 GQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQ 1238
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
+ P S++++E A T+ V C G G++
Sbjct: 1239 -PVPNFP------------------SKLQVEP---------AVDTSG----VQCYGPGIE 1266
Query: 532 QARL--NSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
+ + F VDA +Q G + +A P + V+ G+ + V+Y E
Sbjct: 1267 GQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVEYTPYEE 1326
Query: 697 GTHIIMVRWGDKDIPGSPFMVHV 765
G H + V + +P SPF V V
Sbjct: 1327 GVHSVDVTYDGSPVPSSPFQVPV 1349
Score = 68.6 bits (166), Expect = 2e-11
Identities = 69/273 (25%), Positives = 117/273 (42%), Gaps = 17/273 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLSRAV- 168
G Y V + P G + + ++ I SP+R+ P G + V G GL +
Sbjct: 1602 GTYTVAYVPDVPGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIG 1661
Query: 169 ----VDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
+ ++ V+T AG G + + P S+V+++ E E+G ++ Y A PG Y+
Sbjct: 1662 PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYV 1721
Query: 328 INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
I + +GG H+ SPF GD Q + + + Q +++T +
Sbjct: 1722 ICVRFGGE-HVPNSPFQVTA---LAGDQPTVQTPLRSQQLAPQYNYPQGSQQTWIPERPM 1777
Query: 508 I-CQGLGLKQAR-LNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---F 669
+ GL + R + V F + + I G VR P +V + +N+
Sbjct: 1778 VGVNGLDVTSLRPFDLVIPFTIKKGE---------ITGEVRMPSGKVAQPSITDNKDGTV 1828
Query: 670 TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
TV Y E+G H + +R+ + IPGSP +VD
Sbjct: 1829 TVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVD 1861
Score = 61.6 bits (148), Expect = 3e-09
Identities = 68/272 (25%), Positives = 109/272 (40%), Gaps = 17/272 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y + PR+ H V I SPFR+ VG + P V G G+++ + K
Sbjct: 729 GTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGA-GSHPNKVKVYGPGVAKTGL--K 785
Query: 181 AH----FFVNTTNAGSGSLNVAID------GPSKVNMN---CHETEEGYEFTYVATAPGN 321
AH F V+ T AG G +++ I GP++ +++ + + Y G+
Sbjct: 786 AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGS 845
Query: 322 YIINITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAE 501
Y I + + +P + + +V++E S A
Sbjct: 846 YTIMVLFADQ----ATPTSPI---------------RVKVEPSHD-------------AS 873
Query: 502 KVICQGLGLKQA--RLNSVNSFFVDASQAGYGILLVGIAGPVR--PCEEVVVRHVGNNQF 669
KV +G GL + L F V+A AG G L V +G + +V + +N +
Sbjct: 874 KVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGLAKGDAVRDVDIIDHHDNTY 933
Query: 670 TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
TV Y+ + G + V +G IP SPF V V
Sbjct: 934 TVKYIPVQQGPVGVNVTYGGDHIPKSPFSVGV 965
Score = 43.5 bits (101), Expect = 7e-04
Identities = 27/87 (31%), Positives = 42/87 (48%)
Frame = +1
Query: 505 VICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYV 684
+ G GL +N +F V+ AG G L + I GP + E+ + +V Y+
Sbjct: 1868 ITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYL 1925
Query: 685 VKESGTHIIMVRWGDKDIPGSPFMVHV 765
G + I+V++ D+ IPGSPF V
Sbjct: 1926 PVLPGDYSILVKYNDQHIPGSPFTARV 1952
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Frame = +1
Query: 559 FFVDASQAGYGILLVGIAGPVRPCEE--VVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
F V+ AG G +LV + P EE V + N F+V YV + +GTH + V + +
Sbjct: 304 FTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQ 363
Query: 733 DIPGSPFMVHVD 768
I SPF V+VD
Sbjct: 364 HIAKSPFEVYVD 375
>sp|O75369|FLNB_HUMAN Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
(Thyroid autoantigen) (Truncated actin-binding protein)
(Truncated ABP) (ABP-280 homolog) (ABP-278) (Filamin 3)
(Filamin homolog 1) (Fh1)
Length = 2602
Score = 225 bits (574), Expect = 1e-58
Identities = 117/261 (44%), Positives = 162/261 (62%), Gaps = 7/261 (2%)
Frame = +1
Query: 4 QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
+Y V+F P E+G H + V+ N + GSPF++ VG +P +V A G GL
Sbjct: 2342 KYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTGI 2401
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
++ FF+NTT AG G+L+V I+GPSKV M+C ET EGY+ Y APGNY+I++ YGG H
Sbjct: 2402 QSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPNH 2461
Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEA----SDKRCVSQYAEKTTSYAEKVICQGL 522
IVGSPF A G + + S + +E+ S + C S K +S A KV +G
Sbjct: 2462 IVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIP-KASSDASKVTSKGA 2520
Query: 523 GLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
GL +A + +SF VD S+AG +LL+G+ GP PCEEV ++HVGN Q+ V YVVKE G
Sbjct: 2521 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGD 2580
Query: 703 HIIMVRWGDKDIPGSPFMVHV 765
+++ V+WG++ IPGSPF V V
Sbjct: 2581 YVLAVKWGEEHIPGSPFHVTV 2601
Score = 129 bits (325), Expect = 8e-30
Identities = 89/256 (34%), Positives = 125/256 (48%), Gaps = 1/256 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y V++TP E G H+V V + PI SPF++ V P V A G GL A +K
Sbjct: 1288 GTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTE-GCQPSRVQAQGPGLKEAFTNKP 1346
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
F V T AG G L + ++GPS+ +NC + ++G Y+ APG+Y +NITYGG H
Sbjct: 1347 NVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGG-AH 1405
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I GSPF + +V S+V K+ GLG
Sbjct: 1406 IPGSPFRVPVK-------DVVDPSKV----------------------KIAGPGLG-SGV 1435
Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
R + SF VD+S+AG L V + GP E V + G+ TV Y + G +++ V
Sbjct: 1436 RARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNMVDNGDGTHTVTYTPSQEGPYMVSV 1495
Query: 718 RWGDKDIPGSPFMVHV 765
++ D++IP SPF V V
Sbjct: 1496 KYADEEIPRSPFKVKV 1511
Score = 102 bits (253), Expect = 2e-21
Identities = 71/256 (27%), Positives = 112/256 (43%), Gaps = 1/256 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V++ P E G H + ++ I SP + V + N+ G V A G GL V +K
Sbjct: 1782 GTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNS--GSVSAYGPGLVYGVANKT 1839
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGY-EFTYVATAPGNYIINITYGGNFH 357
A F + T +AG G L++AI+GPSK ++C + ++G TY+ T PG+Y I + Y H
Sbjct: 1840 ATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDK-H 1898
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I GSPFTA +I +RC Q
Sbjct: 1899 IPGSPFTA------------------KITDDSRRC----------------------SQV 1918
Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
+L S F +D S+ L I P E +++ + NN + ++ +E G H++ +
Sbjct: 1919 KLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSI 1978
Query: 718 RWGDKDIPGSPFMVHV 765
+ + SP + V
Sbjct: 1979 KKNGNHVANSPVSIMV 1994
Score = 101 bits (252), Expect = 2e-21
Identities = 70/252 (27%), Positives = 113/252 (44%), Gaps = 1/252 (0%)
Frame = +1
Query: 16 KFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFFV 195
KF pre G + V V + P+ GSP+ + DP V A G GL +V K A F +
Sbjct: 1005 KFIpreEGLYAVDVTYDGHPVPGSPYTVEAS-LPPDPSKVKAHGPGLEGGLVGKPAEFTI 1063
Query: 196 NTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGSP 372
+T AG+G L + ++GP + + C + +G +Y+ T PG Y +NI + HI GSP
Sbjct: 1064 DTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILF-EEVHIPGSP 1122
Query: 373 FTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNSV 552
F A E + + S KV+ G GL+ ++
Sbjct: 1123 FKADIE--------------MPFDPS-----------------KVVASGPGLEHGKVGEA 1151
Query: 553 NSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
V+ S+AG G L + EV +++ + + V YV +G + + +++G +
Sbjct: 1152 GLLSVNCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGE 1211
Query: 733 DIPGSPFMVHVD 768
+P P V V+
Sbjct: 1212 LVPHFPARVKVE 1223
Score = 95.5 bits (236), Expect = 2e-19
Identities = 69/254 (27%), Positives = 111/254 (43%), Gaps = 2/254 (0%)
Frame = +1
Query: 10 GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
G+ F pre G H+V ++ N + SP I V D G GLS + +
Sbjct: 1963 GISFIpreVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSD 2022
Query: 187 FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
F V+T +AG G +++A++GPSKV++ + E+G + +Y T PG YI++ + H+
Sbjct: 2023 FIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADE-HVP 2081
Query: 364 GSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARL 543
GSPFT G E K +++ + + IC L LK +
Sbjct: 2082 GSPFTVKISG----------------EGRVKESITRTSRAPSVATVGSICD-LNLKIPEI 2124
Query: 544 NSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRW 723
NS + + + P E + +G N V +V +E G H + V++
Sbjct: 2125 NSSD-------------MSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKY 2171
Query: 724 GDKDIPGSPFMVHV 765
+ + GSPF V
Sbjct: 2172 RGQHVTGSPFQFTV 2185
Score = 87.8 bits (216), Expect = 3e-17
Identities = 70/253 (27%), Positives = 109/253 (43%), Gaps = 2/253 (0%)
Frame = +1
Query: 13 VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKAHF 189
V+F P+E G H V V+ + + GSPF+ VG V A G GL R A F
Sbjct: 2155 VRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEF 2214
Query: 190 FVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVG 366
+ T AG+G L++A++GPSK + + + G +Y+A PGNY ++I + HI
Sbjct: 2215 SIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPE 2273
Query: 367 SPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLN 546
SP+ I SD A ++ L ++N
Sbjct: 2274 SPYLVPV-----------------IAPSDD-------------ARRLTVMSLQESGLKVN 2303
Query: 547 SVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWG 726
SF + + A G + + P EE V + +++ V ++ E+G H I V++
Sbjct: 2304 QPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFN 2362
Query: 727 DKDIPGSPFMVHV 765
+ GSPF V V
Sbjct: 2363 GSHVVGSPFKVRV 2375
Score = 82.4 bits (202), Expect = 1e-15
Identities = 77/260 (29%), Positives = 111/260 (42%), Gaps = 7/260 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G + V +TP + G +MV V+ + I SPF++ V D V A+G GLS V
Sbjct: 1477 GTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV-LPTYDASKVTASGPGLSSYGVPAS 1535
Query: 181 --AHFFVNTTNAGSGSLNVAI---DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITY 342
F ++ +AG G L V I +G K H+ ++G Y TY+ G Y+I +TY
Sbjct: 1536 LPVDFAIDARDAGEGLLAVQITDQEGKPK-RAIVHDNKDGTYAVTYIPDKTGRYMIGVTY 1594
Query: 343 GGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGL 522
GG+ I SP+ T+TGD A K + G
Sbjct: 1595 GGD-DIPLSPYR--IRATQTGD-----------------------------ASKCLATGP 1622
Query: 523 GL-KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
G+ + F VDA AG G + + P E V + + + Y + G
Sbjct: 1623 GIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPG 1682
Query: 700 THIIMVRWGDKDIPGSPFMV 759
T++I VR+G DIP SPF V
Sbjct: 1683 TYVIYVRFGGVDIPNSPFTV 1702
Score = 79.7 bits (195), Expect = 9e-15
Identities = 69/259 (26%), Positives = 101/259 (38%), Gaps = 6/259 (2%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRA--VVDKK 180
Y V++ P+ +G H V V + I+ SPF + V D V A G GL + +K
Sbjct: 315 YSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAKGPGLEAVGNIANKP 374
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVN----MNCHETEEGYEFTYVATAPGNYIINITYGG 348
+F + T AG G + V ++ P N + + + Y Y PG +++ I + G
Sbjct: 375 TYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAG 434
Query: 349 NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
+ I SPF V Q E A + +GL
Sbjct: 435 D-TIPKSPF-----------------------------VVQVGEACNPNACRASGRGLQP 464
Query: 529 KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHI 708
K R+ F VD AG G L V + GP E V + + + +Y G +
Sbjct: 465 KGVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYS 524
Query: 709 IMVRWGDKDIPGSPFMVHV 765
I + WG IP SPF V V
Sbjct: 525 IAITWGGHHIPKSPFEVQV 543
Score = 73.9 bits (180), Expect = 5e-13
Identities = 67/261 (25%), Positives = 101/261 (38%), Gaps = 6/261 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P + G + V + + I GSPF+ + DP V A+G GL V +
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADI-EMPFDPSKVVASGPGLEHGKVGEA 1151
Query: 181 AHFFVNTTNAGSGSLNVAI--DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGN 351
VN + AG G+L + D +K ++ ++G Y TYV G Y + + YGG
Sbjct: 1152 GLLSVNCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGG- 1210
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
E+ H ++ S+ KV G+ K
Sbjct: 1211 --------------------ELVPHFPARVKVEPAVDTSRI---------KVFGPGIEGK 1241
Query: 532 QARLNSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
+ F VD+ +Q G + IA P E V + + V+Y E G
Sbjct: 1242 DVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGL 1301
Query: 703 HIIMVRWGDKDIPGSPFMVHV 765
H++ V + D IP SPF V V
Sbjct: 1302 HVVEVTYDDVPIPNSPFKVAV 1322
Score = 73.6 bits (179), Expect = 7e-13
Identities = 76/273 (27%), Positives = 120/273 (43%), Gaps = 17/273 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPV----GHYNADPGMVHATGEGLSRA- 165
G VK+ P+E G + V + + + I SP+ + G YN P +V A G GL ++
Sbjct: 602 GSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYN--PDLVRAYGPGLEKSG 659
Query: 166 -VVDKKAHFFVNTTNAGSGSLNV-AIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIIN 333
+V+ A F V+ +AG L + A DG ++++ +G Y +Y + I
Sbjct: 660 CIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIA 719
Query: 334 ITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVIC 513
+ +GG +I SP+ +V I S+ +KV
Sbjct: 720 VVWGG-VNIPHSPY------------------RVNIGQG-------------SHPQKVKV 747
Query: 514 QGLGLKQARL--NSVNSFFVDASQAGYGILLVGIAGPVRPCEE------VVVRHVGNNQF 669
G G++++ L N F VD ++AG G + VGI R E + H N+ F
Sbjct: 748 FGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTF 807
Query: 670 TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
TV YV +G + I V + ++IP SPF V VD
Sbjct: 808 TVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840
Score = 70.1 bits (170), Expect = 7e-12
Identities = 72/258 (27%), Positives = 104/258 (40%), Gaps = 5/258 (1%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
Y + P + G H+V + I SPF + VG +P A+G GL V +
Sbjct: 414 YRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEA-CNPNACRASGRGLQPKGVRIRET 472
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE--EG-YEFTYVATAPGNYIINITYGGN 351
F V+T AGSG L V + GP + + + +G Y F Y + PG Y I IT+GG+
Sbjct: 473 TDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGH 532
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
HI SPF QV EA +KV G GL
Sbjct: 533 -HIPKSPFEV----------------QVGPEAG---------------MQKVRAWGPGLH 560
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+ F V++ + G L I GP + ++ + V Y KE G + +
Sbjct: 561 GGIVGRSADFVVESIGSEVGSLGFAIEGPSQ--AKIEYNDQNDGSCDVKYWPKEPGEYAV 618
Query: 712 MVRWGDKDIPGSPFMVHV 765
+ D+DI SP+M +
Sbjct: 619 HIMCDDEDIKDSPYMAFI 636
Score = 70.1 bits (170), Expect = 7e-12
Identities = 67/274 (24%), Positives = 115/274 (41%), Gaps = 7/274 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G GV + +E G + V ++ N + I SP+ +PV + D + S V++
Sbjct: 2246 GSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQP 2305
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
A F + N G ++ + PS CH +E + Y ++ G + I++ + G+
Sbjct: 2306 ASFAIR-LNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGS 2364
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H+VGSPF + G+ +A + VS Y G GL+
Sbjct: 2365 -HVVGSPFK-----VRVGEPG---------QAGNPALVSAY--------------GTGLE 2395
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
+ FF++ ++AG G L V I GP + C+E + V Y G
Sbjct: 2396 GGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQET------PEGYKVMYTPMAPGN 2449
Query: 703 HIIMVRWGDKD-IPGSPFMVHVD*EIIILTACSN 801
++I V++G + I GSPF V + ++ +N
Sbjct: 2450 YLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSAN 2483
Score = 69.3 bits (168), Expect = 1e-11
Identities = 72/262 (27%), Positives = 108/262 (41%), Gaps = 11/262 (4%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
+ VK+ P +G + + V + I SPFR+ V + D V A G GLS+A V+ K
Sbjct: 807 FTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVDPSH-DASKVKAEGPGLSKAGVENGKP 865
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVN-MNCHETEEGYEFT----YVATAPGNYIINITYG 345
HF V T AG LNV + P + + + + Y+++ Y T GN + +TYG
Sbjct: 866 THFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYG 925
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G+ I SPFT G S++++ + R
Sbjct: 926 GD-PIPKSPFT-------VGVAAPLDLSKIKLNGLENR---------------------- 955
Query: 526 LKQARLNSVNSFFVDASQA-GYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKE 693
+ F VD A G G L V I P R PC +V G T ++ +E
Sbjct: 956 ---VEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPC--LVTPVTGRENSTAKFIpre 1010
Query: 694 SGTHIIMVRWGDKDIPGSPFMV 759
G + + V + +PGSP+ V
Sbjct: 1011 EGLYAVDVTYDGHPVPGSPYTV 1032
Score = 67.0 bits (162), Expect = 6e-11
Identities = 56/261 (21%), Positives = 99/261 (37%), Gaps = 3/261 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P G + + V+ N K I GSPF + S+ +
Sbjct: 1874 GTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITD----------DSRRCSQVKLGSA 1923
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNC---HETEEGYEFTYVATAPGNYIINITYGGN 351
A F ++ + SL +I PS + C +++ G ++++I GN
Sbjct: 1924 ADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSIKKNGN 1983
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H+ SP + + ++ GD A + G GL
Sbjct: 1984 -HVANSPVSIMVVQSEIGD-----------------------------ARRAKVYGRGLS 2013
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+ R ++ F VD AGYG + + + GP + ++ + + V Y G +I+
Sbjct: 2014 EGRTFEMSDFIVDTRDAGYGGISLAVEGPSKV--DIQTEDLEDGTCKVSYFPTVPGVYIV 2071
Query: 712 MVRWGDKDIPGSPFMVHVD*E 774
++ D+ +PGSPF V + E
Sbjct: 2072 STKFADEHVPGSPFTVKISGE 2092
Score = 66.2 bits (160), Expect = 1e-10
Identities = 69/264 (26%), Positives = 107/264 (40%), Gaps = 8/264 (3%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAV-VDK 177
G Y V + P ++G +M+ V I SP+RI D ATG G++ V +
Sbjct: 1574 GTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQ-TGDASKCLATGPGIASTVKTGE 1632
Query: 178 KAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYIINITYGG 348
+ F V+ AG G + + P ++ + E E+G Y+ Y A PG Y+I + +GG
Sbjct: 1633 EVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG 1692
Query: 349 NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
I SPFT + D EV + + A C + T A + GL
Sbjct: 1693 -VDIPNSPFTVMAT-----DGEVTAVEEAPVNA----CPPGFRPWVTEEAYVPVSDMNGL 1742
Query: 529 KQARLNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---FTVDYVVKES 696
+ V F V + I G V P + + +N+ TV Y E
Sbjct: 1743 GFKPFDLVIPFAVRKGE---------ITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEV 1793
Query: 697 GTHIIMVRWGDKDIPGSPFMVHVD 768
G H + +++ IP SP +V+
Sbjct: 1794 GLHEMHIKYMGSHIPESPLQFYVN 1817
Score = 64.3 bits (155), Expect = 4e-10
Identities = 61/258 (23%), Positives = 102/258 (39%), Gaps = 3/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y ++ P G + + + I SPF + VG A V A G GL +V +
Sbjct: 509 GVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVGP-EAGMQKVRAWGPGLHGGIVGRS 567
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
A F V + + GSL AI+GPS+ + ++ +G + Y PG Y ++I
Sbjct: 568 ADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDE-D 626
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I SP+ A G + V G GL+++
Sbjct: 627 IKDSPYMAFIHPATGGYN----------------------------PDLVRAYGPGLEKS 658
Query: 538 R--LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+N++ F VD AG L + ++ +++ + + Y ++ H I
Sbjct: 659 GCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTI 718
Query: 712 MVRWGDKDIPGSPFMVHV 765
V WG +IP SP+ V++
Sbjct: 719 AVVWGGVNIPHSPYRVNI 736
Score = 61.2 bits (147), Expect = 3e-09
Identities = 65/263 (24%), Positives = 104/263 (39%), Gaps = 8/263 (3%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y V + P +G + + ++ + + P R+ V D + G G+ V ++
Sbjct: 1188 GTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKV-EPAVDTSRIKVFGPGIEGKDVFRE 1246
Query: 181 A--HFFVNT---TNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINI 336
A F V++ T G + I PS + C T+ Y+ Y G +++ +
Sbjct: 1247 ATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEV 1306
Query: 337 TYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
TY + I SPF K TE Q S+V+ Q
Sbjct: 1307 TYD-DVPIPNSPF-------KVAVTEGCQPSRVQ------------------------AQ 1334
Query: 517 GLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
G GLK+A N N F V AG G L + + GP ++ R + + +Y+
Sbjct: 1335 GPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSE--SKINCRDNKDGSCSAEYIPFAP 1392
Query: 697 GTHIIMVRWGDKDIPGSPFMVHV 765
G + + + +G IPGSPF V V
Sbjct: 1393 GDYDVNITYGGAHIPGSPFRVPV 1415
Score = 53.9 bits (128), Expect = 5e-07
Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 3/258 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P G ++V + + + GSPF + + + T S A V
Sbjct: 2055 GTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSI 2114
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAP---GNYIINITYGGN 351
+ S ++ + PS G V P G + +++ Y G
Sbjct: 2115 CDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQ 2174
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H+ GSPF G A KV G GL+
Sbjct: 2175 -HVTGSPFQFTVGPLGEGG-----------------------------AHKVRAGGPGLE 2204
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+ F + +AG G L + + GP + E+ N V Y+ +E G + +
Sbjct: 2205 RGEAGVPAEFSIWTREAGAGGLSIAVEGPSK--AEITFDDHKNGSCGVSYIAQEPGNYEV 2262
Query: 712 MVRWGDKDIPGSPFMVHV 765
+++ D+ IP SP++V V
Sbjct: 2263 SIKFNDEHIPESPYLVPV 2280
Score = 38.5 bits (88), Expect = 0.024
Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 2/72 (2%)
Frame = +1
Query: 559 FFVDASQAGYGILLVGIAGPVRPCEEVVVRHVG--NNQFTVDYVVKESGTHIIMVRWGDK 732
F VD AG G ++V + P EE V N ++V+Y+ K +G H + V + +
Sbjct: 277 FTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQ 336
Query: 733 DIPGSPFMVHVD 768
I SPF V VD
Sbjct: 337 HISKSPFEVSVD 348
>sp|Q9MZD2|FLNB_RABIT Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
(ABP-280-like protein) (C254)
Length = 294
Score = 225 bits (573), Expect = 1e-58
Identities = 117/261 (44%), Positives = 162/261 (62%), Gaps = 7/261 (2%)
Frame = +1
Query: 4 QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
+Y V+F P E+G H + V+ N + GSPF++ VG +P +V A G GL
Sbjct: 34 KYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGAGLEGGTTGI 93
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
++ FF+NTT AG G+L+V I+GPSKV M+C ET EGY+ Y APGNY+I + YGG H
Sbjct: 94 QSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLIGVKYGGPNH 153
Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEA----SDKRCVSQYAEKTTSYAEKVICQGL 522
IVGSPF A G + G + S + +E+ S + C S K +S A KV +G
Sbjct: 154 IVGSPFKAKVTGQRLVGPGSTNETSSILVESVTRSSTETCYSAIP-KASSDASKVTSKGA 212
Query: 523 GLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
GL +A + +SF VD S+AG +LL+G+ GP PCEEV ++HVG+ Q+ V YVVKE G
Sbjct: 213 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGSQQYNVTYVVKERGE 272
Query: 703 HIIMVRWGDKDIPGSPFMVHV 765
+++ V+WG++ IPGSPF V V
Sbjct: 273 YVLAVKWGEEHIPGSPFHVTV 293
Score = 32.7 bits (73), Expect = 1.3
Identities = 16/53 (30%), Positives = 27/53 (50%)
Frame = +1
Query: 607 IAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
+ P EE V + +++ V ++ E+G H I V++ + GSPF V V
Sbjct: 15 VHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 67
>sp|Q80X90|FLNB_MOUSE Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
(ABP-280-like protein)
Length = 2602
Score = 215 bits (548), Expect = 1e-55
Identities = 113/261 (43%), Positives = 158/261 (60%), Gaps = 7/261 (2%)
Frame = +1
Query: 4 QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
+Y V+F P E+G H + V+ N + GSPF++ VG +P +V A G GL
Sbjct: 2342 KYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGAGLETGTTGI 2401
Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
++ FF+NTT AG G+L+V I+GPSKV M+C E EGY+ Y APGNY+I + YGG H
Sbjct: 2402 QSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEIPEGYKVMYTPMAPGNYLIGVKYGGPNH 2461
Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEA----SDKRCVSQYAEKTTSYAEKVICQGL 522
I SPF A G + + S + +E+ S + C S K++S A KV +G
Sbjct: 2462 ISRSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIP-KSSSDASKVTSKGA 2520
Query: 523 GLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
GL +A + +SF VD S+AG +LL+G+ GP PCEEV ++HVG Q+ V YVVKE G
Sbjct: 2521 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGKQQYNVTYVVKERGD 2580
Query: 703 HIIMVRWGDKDIPGSPFMVHV 765
+++ V+WG++ IPGSPF V V
Sbjct: 2581 YVLAVKWGEEHIPGSPFHVTV 2601
Score = 133 bits (334), Expect = 7e-31
Identities = 92/257 (35%), Positives = 125/257 (48%), Gaps = 2/257 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y V++TP E G H+V V + PI SPF++ V P VHA G GL A +K
Sbjct: 1288 GTYQVEYTPFEKGFHVVEVTYDDVPIPNSPFKVAVTE-GCQPSRVHAQGPGLKEAFTNKS 1346
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
F V T AG G L + ++GPS+ +NC + ++G Y+ APG+Y +NITYGG H
Sbjct: 1347 NVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGG-VH 1405
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQ- 534
I GSPF + +V S+V+I G GL
Sbjct: 1406 IPGSPF-------RVPSKDVVDPSKVKI------------------------AGPGLSSC 1434
Query: 535 ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
R SF VD+S+AG L V + GP E V V G+ TV Y + G +I+
Sbjct: 1435 VRACIPQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYIVS 1494
Query: 715 VRWGDKDIPGSPFMVHV 765
V++ D++IP SPF V V
Sbjct: 1495 VKYADEEIPRSPFKVKV 1511
Score = 103 bits (257), Expect = 6e-22
Identities = 71/256 (27%), Positives = 113/256 (44%), Gaps = 1/256 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V++ P E G H + ++ I SP + V + N+ G V A G GL V +K
Sbjct: 1782 GTVTVRYAPTEVGLHEMHIKYRGSHIPESPLQFYVNYPNS--GSVSAYGPGLVYGVANKT 1839
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGY-EFTYVATAPGNYIINITYGGNFH 357
A F + T +AG G L++AI+GPSK ++C + ++G TY+ T PG+Y I + Y H
Sbjct: 1840 ATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDK-H 1898
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I GSPFTA +I ++RC Q
Sbjct: 1899 IPGSPFTA------------------KITDDNRRC----------------------SQV 1918
Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
+L S F +D S+ L I P E +++ + NN + ++ +E G H++ +
Sbjct: 1919 KLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSI 1978
Query: 718 RWGDKDIPGSPFMVHV 765
+ + SP + V
Sbjct: 1979 KKNGNHVANSPVSIMV 1994
Score = 100 bits (250), Expect = 4e-21
Identities = 71/252 (28%), Positives = 112/252 (44%), Gaps = 1/252 (0%)
Frame = +1
Query: 16 KFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFFV 195
KF pre G V V + P+ GSP+ + DP V A G GL +V K A F +
Sbjct: 1005 KFIpreEGLFAVDVTYDGHPVPGSPYTVEAS-LPPDPTKVKAHGPGLEGGLVGKPAEFTI 1063
Query: 196 NTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGSP 372
+T AG+G L + ++GP + + C + +G +Y+ T PG Y +NI + HI GSP
Sbjct: 1064 DTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILF-EEVHIPGSP 1122
Query: 373 FTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNSV 552
F A E + + S KV+ G GL+ ++
Sbjct: 1123 FKADIE--------------MPFDPS-----------------KVVASGPGLEHGKVGEP 1151
Query: 553 NSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
VD S+AG G L + EV +++ + + V YV +G + + +++G +
Sbjct: 1152 GILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGE 1211
Query: 733 DIPGSPFMVHVD 768
+P P V V+
Sbjct: 1212 LVPHFPAWVKVE 1223
Score = 94.7 bits (234), Expect = 3e-19
Identities = 68/254 (26%), Positives = 111/254 (43%), Gaps = 2/254 (0%)
Frame = +1
Query: 10 GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
G+ F pre G H+V ++ N + SP I V D G+GLS + +
Sbjct: 1963 GISFIpreVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGQGLSEGRTFEMSD 2022
Query: 187 FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
F V+T +AG G +++A++GPSKV++ + E+G + +Y T PG YI++ + H+
Sbjct: 2023 FIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADE-HVP 2081
Query: 364 GSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARL 543
GSPFT G E + +++ + IC L LK +
Sbjct: 2082 GSPFTVKISG----------------EGRVRESITRTSRAPAVATVGSICD-LNLKIPEI 2124
Query: 544 NSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRW 723
NS + + + P E + +G N V +V +E G H + V++
Sbjct: 2125 NSSD-------------MSAHVTSPSGHVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKY 2171
Query: 724 GDKDIPGSPFMVHV 765
+ + GSPF V
Sbjct: 2172 RGQHVTGSPFQFTV 2185
Score = 91.7 bits (226), Expect = 2e-18
Identities = 73/253 (28%), Positives = 113/253 (44%), Gaps = 2/253 (0%)
Frame = +1
Query: 13 VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKAHF 189
V+F P+E G H V V+ + + GSPF+ VG V A G GL R A F
Sbjct: 2155 VRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGIPAEF 2214
Query: 190 FVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVG 366
+ T AG+G L++A++GPSK + + + G +Y+A PGNY ++I + HI
Sbjct: 2215 SIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPD 2273
Query: 367 SPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLN 546
SP+ V + D RC++ + Q GLK +N
Sbjct: 2274 SPYLV----------------PVIAPSDDARCLTVLS-----------LQESGLK---VN 2303
Query: 547 SVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWG 726
SF + + A G + + P EE V + +++ V ++ E+G H I V++
Sbjct: 2304 QPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFN 2362
Query: 727 DKDIPGSPFMVHV 765
+ GSPF V V
Sbjct: 2363 GSHVVGSPFKVRV 2375
Score = 81.6 bits (200), Expect = 2e-15
Identities = 76/261 (29%), Positives = 112/261 (42%), Gaps = 8/261 (3%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G + V +TP + G ++V V+ + I SPF++ V D V A+G GLS V
Sbjct: 1477 GTHTVTYTPSQEGPYIVSVKYADEEIPRSPFKVKVLP-TYDASKVTASGPGLSAYGVPAS 1535
Query: 181 --AHFFVNTTNAGSGSLNVAIDG----PSKVNMNCHETEEG-YEFTYVATAPGNYIINIT 339
F ++ +AG G L V I P + + H+ ++G Y TY+ G Y+I +T
Sbjct: 1536 LPVEFAIDARDAGEGLLAVQITDQEGKPQRATV--HDNKDGTYAVTYIPDKTGRYMIGVT 1593
Query: 340 YGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQG 519
YGG+ +I SP+ T+TGD A K + G
Sbjct: 1594 YGGD-NIPLSPYR--IRATQTGD-----------------------------ASKCLATG 1621
Query: 520 LGL-KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
G+ + F VDA AG G + I P E V + + + Y +
Sbjct: 1622 PGIAPTVKTGEEVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENEDGTYDIFYTAAKP 1681
Query: 697 GTHIIMVRWGDKDIPGSPFMV 759
GT++I VR+G DIP SPF V
Sbjct: 1682 GTYVIYVRFGGVDIPNSPFTV 1702
Score = 79.0 bits (193), Expect = 2e-14
Identities = 67/259 (25%), Positives = 103/259 (39%), Gaps = 6/259 (2%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRA--VVDKK 180
Y V++ P+ +G H V V + I+ SPF + V D V A G GL + +K
Sbjct: 315 YSVEYLPKVTGLHKVIVLFAGQHISKSPFEVNVDKAQGDASKVTAKGPGLETTGNIANKP 374
Query: 181 AHFFVNTTNAGSGSLNVAIDGP-SKVNMNCHETEEG---YEFTYVATAPGNYIINITYGG 348
+F + T AG G + + ++ P K ++ + G Y Y PG +++ +++ G
Sbjct: 375 TYFDIYTAGAGVGDIGIEVEDPQGKNSVELLVEDRGNQVYRCVYKPVQPGPHVVKVSFAG 434
Query: 349 NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
+ I SPF Q E A + +GL
Sbjct: 435 D-AIPKSPFGV-----------------------------QIGEACNPNACRASGRGLQP 464
Query: 529 KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHI 708
K R+ F VD AG G L V + GP E V + + ++ +Y G +
Sbjct: 465 KGVRIRETADFKVDTKAAGSGELGVTVKGPGGLEELVKQKGFLDGVYSFEYYPSTPGKYS 524
Query: 709 IMVRWGDKDIPGSPFMVHV 765
+ V WG IP SPF V V
Sbjct: 525 VAVTWGGHHIPKSPFEVQV 543
Score = 73.2 bits (178), Expect = 9e-13
Identities = 78/273 (28%), Positives = 121/273 (44%), Gaps = 17/273 (6%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPV----GHYNADPGMVHATGEGLSRA- 165
G VK+ P+E G + V + + + I SP+ + G YN P +V A G GL ++
Sbjct: 602 GSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGDYN--PDLVQAYGPGLEKSG 659
Query: 166 -VVDKKAHFFVNTTNAGSGSLNV-AIDGPSK-VNMNCHETEEG-YEFTYVATAPGNYIIN 333
++ A F V+ +AGS L + A DG + +++ +G Y +Y + I
Sbjct: 660 CTINNPAEFIVDPKDAGSAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPLKAIKHTIA 719
Query: 334 ITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVIC 513
+ +GG +I SP+ +V I S+ +KV
Sbjct: 720 VVWGG-VNIPHSPY------------------RVNIGQG-------------SHPQKVKV 747
Query: 514 QGLGLKQARL--NSVNSFFVDASQAGYGILLVGIAGPVRPC---EEVV---VRHVGNNQF 669
G G++++ L N F VD ++AG G + VGI R EE V + H N+ F
Sbjct: 748 FGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTF 807
Query: 670 TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
TV YV G + I V + ++IP SPF V VD
Sbjct: 808 TVKYVPPAPGRYTIKVLFASQEIPASPFRVKVD 840
Score = 72.0 bits (175), Expect = 2e-12
Identities = 72/258 (27%), Positives = 105/258 (40%), Gaps = 5/258 (1%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
Y + P + G H+V V I SPF + +G +P A+G GL V +
Sbjct: 414 YRCVYKPVQPGPHVVKVSFAGDAIPKSPFGVQIGEA-CNPNACRASGRGLQPKGVRIRET 472
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHE---TEEGYEFTYVATAPGNYIINITYGGN 351
A F V+T AGSG L V + GP + + + Y F Y + PG Y + +T+GG+
Sbjct: 473 ADFKVDTKAAGSGELGVTVKGPGGLEELVKQKGFLDGVYSFEYYPSTPGKYSVAVTWGGH 532
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
HI SPF QV EA +KV G GL
Sbjct: 533 -HIPKSPFEV----------------QVGPEAG---------------MQKVRAWGPGLH 560
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+ F V++ + G L I GP + E ++ G+ V Y KE G + +
Sbjct: 561 GGIVGRSADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGS--CDVKYWPKEPGEYAV 618
Query: 712 MVRWGDKDIPGSPFMVHV 765
+ D+DI SP+M +
Sbjct: 619 HIMCDDEDIKDSPYMAFI 636
Score = 70.1 bits (170), Expect = 7e-12
Identities = 71/271 (26%), Positives = 111/271 (40%), Gaps = 16/271 (5%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVV--D 174
G Y +TP ++ H + V I SP+R+ +G + P V G G+ R+ + +
Sbjct: 702 GTYACSYTPLKAIKHTIAVVWGGVNIPHSPYRVNIGQ-GSHPQKVKVFGPGVERSGLKAN 760
Query: 175 KKAHFFVNTTNAGSGSLNVAIDGPSKVNMN---------CHETEEGYEFTYVATAPGNYI 327
+ HF V+ T AG G ++V I ++V + H + + YV APG Y
Sbjct: 761 EPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTFTVKYVPPAPGRYT 820
Query: 328 INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
I + + I SPF +V+++ S A KV
Sbjct: 821 IKVLFASQ-EIPASPF------------------RVKVDPSHD-------------ASKV 848
Query: 508 ICQGLGLKQARLNS--VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNN---QFT 672
+G GL +A + + F V AG L+V + P+ P E V + +N T
Sbjct: 849 KAEGPGLSKAGVENGKPTHFTVHTKGAGKAPLIVQFSSPL-PGEAVKDLDIIDNYDYSHT 907
Query: 673 VDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
V Y + G ++V +G IP SPF V V
Sbjct: 908 VKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938
Score = 70.1 bits (170), Expect = 7e-12
Identities = 67/274 (24%), Positives = 115/274 (41%), Gaps = 7/274 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G GV + +E G + V ++ N + I SP+ +PV + D + S V++
Sbjct: 2246 GSCGVSYIAQEPGNYEVSIKFNDEHIPDSPYLVPVIAPSDDARCLTVLSLQESGLKVNQP 2305
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
A F + N G ++ + PS CH +E + Y ++ G + I++ + G+
Sbjct: 2306 ASFAIR-LNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGS 2364
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H+VGSPF + G+ +A + VS Y G GL+
Sbjct: 2365 -HVVGSPFK-----VRVGEPG---------QAGNPALVSAY--------------GAGLE 2395
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
+ FF++ +QAG G L V I GP + C+E+ + V Y G
Sbjct: 2396 TGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEI------PEGYKVMYTPMAPGN 2449
Query: 703 HIIMVRWGDKD-IPGSPFMVHVD*EIIILTACSN 801
++I V++G + I SPF V + ++ +N
Sbjct: 2450 YLIGVKYGGPNHISRSPFKAKVTGQRLVSPGSAN 2483
Score = 67.4 bits (163), Expect = 5e-11
Identities = 65/263 (24%), Positives = 103/263 (39%), Gaps = 8/263 (3%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P + G + V + + I GSPF+ + DP V A+G GL V +
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADI-EMPFDPSKVVASGPGLEHGKVGEP 1151
Query: 181 AHFFVNTTNAGSGSLNVAI--DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGN 351
V+ + AG G+L + D +K ++ ++G Y TYV G Y + + YGG
Sbjct: 1152 GILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGG- 1210
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQH--SQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
E+ H + V++E + + K G+
Sbjct: 1211 --------------------ELVPHFPAWVKVEPA-----------IDTSGIKAFGPGIE 1239
Query: 526 LKQARLNSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
K + F VD+ +Q G + I P E V+ + + V+Y E
Sbjct: 1240 GKDVFREATTDFTVDSRPLTQVGGDHIKAQITNPSGASTECFVKDNADGTYQVEYTPFEK 1299
Query: 697 GTHIIMVRWGDKDIPGSPFMVHV 765
G H++ V + D IP SPF V V
Sbjct: 1300 GFHVVEVTYDDVPIPNSPFKVAV 1322
Score = 67.4 bits (163), Expect = 5e-11
Identities = 56/261 (21%), Positives = 100/261 (38%), Gaps = 3/261 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G V + P G + + V+ N K I GSPF + N S+ +
Sbjct: 1874 GTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDN----------RRCSQVKLGSA 1923
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNC---HETEEGYEFTYVATAPGNYIINITYGGN 351
A F ++ + +L +I PS + C +++ G ++++I GN
Sbjct: 1924 ADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSIKKNGN 1983
Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
H+ SP + + ++ GD A + G GL
Sbjct: 1984 -HVANSPVSIMVVQSEIGD-----------------------------ARRAKVYGQGLS 2013
Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
+ R ++ F VD AGYG + + + GP + ++ + + V Y G +I+
Sbjct: 2014 EGRTFEMSDFIVDTRDAGYGGISLAVEGPSKV--DIQTEDLEDGTCKVSYFPTVPGVYIV 2071
Query: 712 MVRWGDKDIPGSPFMVHVD*E 774
++ D+ +PGSPF V + E
Sbjct: 2072 STKFADEHVPGSPFTVKISGE 2092
Score = 65.9 bits (159), Expect = 1e-10
Identities = 70/260 (26%), Positives = 106/260 (40%), Gaps = 4/260 (1%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAV-VDK 177
G Y V + P ++G +M+ V I SP+RI D ATG G++ V +
Sbjct: 1574 GTYAVTYIPDKTGRYMIGVTYGGDNIPLSPYRIRATQ-TGDASKCLATGPGIAPTVKTGE 1632
Query: 178 KAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYIINITYGG 348
+ F V+ AG G + I P ++ + E E+G Y+ Y A PG Y+I + +GG
Sbjct: 1633 EVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG 1692
Query: 349 NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
I SPFT + D EV + + A C + T A + GL
Sbjct: 1693 -VDIPNSPFTVMAT-----DGEVTAMEEAPVNA----CPPGFRPWVTEEAYVPVSDMNGL 1742
Query: 529 KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHI 708
+ V F A + G V + + E+V G TV Y E G H
Sbjct: 1743 GFKPFDLVIPF---AVRKGEITGTVHMPSGKKATPEIVDNKDGT--VTVRYAPTEVGLHE 1797
Query: 709 IMVRWGDKDIPGSPFMVHVD 768
+ +++ IP SP +V+
Sbjct: 1798 MHIKYRGSHIPESPLQFYVN 1817
Score = 65.1 bits (157), Expect = 2e-10
Identities = 66/257 (25%), Positives = 102/257 (39%), Gaps = 2/257 (0%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y ++ P G + V V I SPF + VG A V A G GL +V +
Sbjct: 509 GVYSFEYYPSTPGKYSVAVTWGGHHIPKSPFEVQVGP-EAGMQKVRAWGPGLHGGIVGRS 567
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
A F V + + G+L AI+GPS+ + + +G + Y PG Y ++I
Sbjct: 568 ADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDE-D 626
Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
I SP+ A TGD + V Y GL
Sbjct: 627 IKDSPYMAFIH-PATGDYNPD-------------LVQAYG------------PGLEKSGC 660
Query: 538 RLNSVNSFFVDASQAGYGIL-LVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
+N+ F VD AG L ++ G +P ++ ++ + + Y ++ H I
Sbjct: 661 TINNPAEFIVDPKDAGSAPLKILAQDGEGQPI-DIQMKSRMDGTYACSYTPLKAIKHTIA 719
Query: 715 VRWGDKDIPGSPFMVHV 765
V WG +IP SP+ V++
Sbjct: 720 VVWGGVNIPHSPYRVNI 736
Score = 64.3 bits (155), Expect = 4e-10
Identities = 71/262 (27%), Positives = 105/262 (40%), Gaps = 11/262 (4%)
Frame = +1
Query: 7 YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
+ VK+ P G + + V + I SPFR+ V + D V A G GLS+A V+ K
Sbjct: 807 FTVKYVPPAPGRYTIKVLFASQEIPASPFRVKVDP-SHDASKVKAEGPGLSKAGVENGKP 865
Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVN-MNCHETEEGYEFT----YVATAPGNYIINITYG 345
HF V+T AG L V P + + + Y+++ Y T GN + +TYG
Sbjct: 866 THFTVHTKGAGKAPLIVQFSSPLPGEAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYG 925
Query: 346 GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
G+ I SPFT G S+++I + R
Sbjct: 926 GD-PIPKSPFT-------VGVAAPLDLSKIKINGLENR---------------------- 955
Query: 526 LKQARLNSVNSFFVDASQA-GYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKE 693
+ F +D + A G G L V I P R PC +V G T ++ +E
Sbjct: 956 ---VEVGKDQEFAIDTNGAGGQGKLDVTILSPSRKVVPC--LVAPVAGRECSTAKFIpre 1010
Query: 694 SGTHIIMVRWGDKDIPGSPFMV 759
G + V + +PGSP+ V
Sbjct: 1011 EGLFAVDVTYDGHPVPGSPYTV 1032
Score = 39.7 bits (91), Expect = 0.011
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Frame = +1
Query: 559 FFVDASQAGYGILLVGIAGPVRPCEEVVVRHVG--NNQFTVDYVVKESGTHIIMVRWGDK 732
F VD AG G ++V + P EE V N ++V+Y+ K +G H ++V + +
Sbjct: 277 FTVDTISAGQGDVMVFVEDPEGNKEEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFAGQ 336
Query: 733 DIPGSPFMVHVD 768
I SPF V+VD
Sbjct: 337 HISKSPFEVNVD 348
>sp|P13466|GELA_DICDI Gelation factor (Actin binding protein 120) (ABP-120)
Length = 857
Score = 58.2 bits (139), Expect = 3e-08
Identities = 61/266 (22%), Positives = 106/266 (39%), Gaps = 11/266 (4%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y V++ P + G H V V +P+ P + + N+D + G G +A +
Sbjct: 412 GSYDVEYKPTKGGDHTVEVFLRGEPLAQGPTEVKI--LNSDSQNSYCDGPGFEKAQAKRP 469
Query: 181 AHFFVNTTN-------AGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINI 336
F +++ AG V+I GP VN+ + ++G Y Y PG+Y I +
Sbjct: 470 TEFTIHSVGADNKPCAAGGDPFQVSISGPHPVNVGITDNDDGTYTVAYTPEQPGDYEIQV 529
Query: 337 TYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
T E K + + A+ SYAE
Sbjct: 530 TLND-------------EAIKDIPKSIH--------------IKPAADPEKSYAEGPGLD 562
Query: 517 G---LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVV 687
G + ++++V+ V + G G +V I GP P + V+V + G+ + V++
Sbjct: 563 GGECFQPSKFKIHAVDPDGVHRTDGGDG-FVVTIEGPA-PVDPVMVDN-GDGTYDVEFEP 619
Query: 688 KESGTHIIMVRWGDKDIPGSPFMVHV 765
KE+G ++I + ++ G P V V
Sbjct: 620 KEAGDYVINLTLDGDNVNGFPKTVTV 645
Score = 52.8 bits (125), Expect = 1e-06
Identities = 66/266 (24%), Positives = 100/266 (37%), Gaps = 15/266 (5%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVH--ATGEGLSRAVVD 174
G Y V+F P+E+G +++ + + +NG P + V P H A GEGL + +
Sbjct: 611 GTYDVEFEPKEAGDYVINLTLDGDNVNGFPKTVTV---KPAPSAEHSYAEGEGLVKVFDN 667
Query: 175 KKAHFFVNTTNA-------GSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNY 324
A F + + G VAI+GP + ++ T+ Y Y A GNY
Sbjct: 668 APAEFTIFAVDTKGVARTDGGDPFEVAINGPDGLVVDAKVTDNNDGTYGVVYDAPVEGNY 727
Query: 325 IINITYGGNFHIVGSPFTAVC-EGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAE 501
+N+T GN I P C EG D S + T + A
Sbjct: 728 NVNVTLRGN-PIKNMPIDVKCIEGANGED-------------------SSFGSFTFTVAA 767
Query: 502 KVICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQ--FTV 675
K + V ++ D + V I G P EE+ + + N +T
Sbjct: 768 K----------NKKGEVKTYGGDKFE-------VSITG---PAEEITLDAIDNQDGTYTA 807
Query: 676 DYVVKESGTHIIMVRWGDKDIPGSPF 753
Y + +G V+ K I GSPF
Sbjct: 808 AYSLVGNGRFSTGVKLNGKHIEGSPF 833
Score = 34.3 bits (77), Expect = 0.45
Identities = 59/271 (21%), Positives = 95/271 (35%), Gaps = 16/271 (5%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
G Y +T + V V+ + SP+ + + +D +A G GL V
Sbjct: 312 GIYDASYTATVPQDYTVVVQLDDVHCKDSPYNVKID--GSDAQHSNAYGPGLEGGKVGVP 369
Query: 181 AHFFVN-------TTNAGSGSLNVAIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIIN 333
A F + T G V + P V+ + +G Y+ Y T G++ +
Sbjct: 370 AAFKIQGRNKDGETVTQGGDDFTVKVQSPEGPVDAQIKDNGDGSYDVEYKPTKGGDHTVE 429
Query: 334 ITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVIC 513
+ G E G TEV+ I SD + SY C
Sbjct: 430 VFLRG-------------EPLAQGPTEVK------ILNSDSQ---------NSY-----C 456
Query: 514 QGLGLKQARLNSVNSFFVDA-------SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFT 672
G G ++A+ F + + AG V I+GP P V + + +T
Sbjct: 457 DGPGFEKAQAKRPTEFTIHSVGADNKPCAAGGDPFQVSISGP-HPVN-VGITDNDDGTYT 514
Query: 673 VDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
V Y ++ G + I V D+ I P +H+
Sbjct: 515 VAYTPEQPGDYEIQVTLNDEAIKDIPKSIHI 545
>sp|Q9R1R2|TRIM3_MOUSE Tripartite motif protein 3 (RING finger protein 22) (RING finger
protein HAC1)
Length = 744
Score = 37.0 bits (84), Expect = 0.069
Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 10/89 (11%)
Frame = +1
Query: 139 ATGEGLSRAVVDKKAHFFVNT-------TNAGSGSLNVAIDGPSKVNMNCHETEE---GY 288
ATGEGL +A+V + A V T GS L I GP V + + Y
Sbjct: 327 ATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELCAEITGPDGVRLAVPVVDHKNGTY 386
Query: 289 EFTYVATAPGNYIINITYGGNFHIVGSPF 375
E Y A G+ ++++ G + GSPF
Sbjct: 387 ELVYTARTEGDLLLSVLLYGQ-PVRGSPF 414
>sp|Q6PFY8|TRI45_MOUSE Tripartite motif protein 45
Length = 580
Score = 36.6 bits (83), Expect = 0.091
Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Frame = +1
Query: 1 GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGH-YNADPGMVH 138
G Y V +TP+E G + V+V ++ + GSPF + V + PG+ H
Sbjct: 463 GSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHRPHPGVFH 509
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,576,298
Number of Sequences: 369166
Number of extensions: 2299477
Number of successful extensions: 6138
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5572
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5958
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)