Planaria EST Database


DrC_02403

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_02403
         (851 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q8VHX6|FLNC_MOUSE  Filamin-C (Gamma-filamin) (Filamin-2) ...   230   3e-60
sp|Q14315|FLNC_HUMAN  Filamin-C (Gamma-filamin) (Filamin-2) ...   228   1e-59
sp|P21333|FLNA_HUMAN  Filamin-A (Alpha-filamin) (Filamin-1) ...   227   4e-59
sp|Q8BTM8|FLNA_MOUSE  Filamin-A (Alpha-filamin) (Filamin-1) ...   227   4e-59
sp|O75369|FLNB_HUMAN  Filamin-B (FLN-B) (Beta-filamin) (Acti...   225   1e-58
sp|Q9MZD2|FLNB_RABIT  Filamin-B (FLN-B) (Beta-filamin) (Acti...   225   1e-58
sp|Q80X90|FLNB_MOUSE  Filamin-B (FLN-B) (Beta-filamin) (Acti...   215   1e-55
sp|P13466|GELA_DICDI  Gelation factor (Actin binding protein...    58   3e-08
sp|Q9R1R2|TRIM3_MOUSE  Tripartite motif protein 3 (RING fing...    37   0.069
sp|Q6PFY8|TRI45_MOUSE  Tripartite motif protein 45                 37   0.091
>sp|Q8VHX6|FLNC_MOUSE Filamin-C (Gamma-filamin) (Filamin-2) (FLN-C) (Actin-binding-like
            protein) (ABP-L) (ABP-280-like protein)
          Length = 1144

 Score =  230 bits (587), Expect = 3e-60
 Identities = 122/262 (46%), Positives = 164/262 (62%), Gaps = 8/262 (3%)
 Frame = +1

Query: 4    QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
            ++ ++F P E+G H + V+ N   I GSPF+I VG  +   DPG+V A G GL       
Sbjct: 882  KHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGV 941

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
             + F VNT NAGSG+L+V IDGPSKV ++C E  EG+  TY   APGNY+I I YGG  H
Sbjct: 942  SSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQH 1001

Query: 358  IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDKRCVSQYAE-----KTTSYAEKVICQG 519
            IVGSPF A   G + +G   + + S V +E   K   S+ A      K +S A KV+ +G
Sbjct: 1002 IVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGASYSSIPKFSSDASKVVTRG 1061

Query: 520  LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
             GL QA +   NSF VD S+AG  +++VG+ GP  PCEEV V+H+GN  + V Y VKE G
Sbjct: 1062 PGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKG 1121

Query: 700  THIIMVRWGDKDIPGSPFMVHV 765
             +I++V+WGD+ +PGSPF V+V
Sbjct: 1122 DYILIVKWGDESVPGSPFKVNV 1143

 Score =  107 bits (266), Expect = 5e-23
 Identities = 58/130 (44%), Positives = 77/130 (59%), Gaps = 2/130 (1%)
 Frame = +1

Query: 10  GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
           G+ FTP+E G H+V V  + K +  SPF+I VG     D   V   G+GLS     + A 
Sbjct: 421 GISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGQTFQVAE 480

Query: 187 FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
           F V+T NAG G L ++I+GPSKV++NC + E+G  + TY  T PG YIINI +    H+ 
Sbjct: 481 FIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADK-HVP 539

Query: 364 GSPFTAVCEG 393
           GSPFT    G
Sbjct: 540 GSPFTVKVTG 549

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 75/256 (29%), Positives = 114/256 (44%), Gaps = 1/256 (0%)
 Frame = +1

Query: 1   GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
           G   V++ P E G H + ++ +   I GSP +  V   N+    V A G GLS  +V+K 
Sbjct: 239 GTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRH--VSAYGPGLSHGMVNKP 296

Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
           A F + T +AG G L++A++GPSK  + C + ++G    +Y+ TAPG+Y I + +    H
Sbjct: 297 ATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-H 355

Query: 358 IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
           I GSPFTA                  +I   D    SQ    T++     I +G      
Sbjct: 356 IPGSPFTA------------------KITGDDSMRTSQLNVGTSTDVSLKITEG------ 391

Query: 538 RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
                     D SQ     L   I  P    E  +++ + N    + +  KE G H++ V
Sbjct: 392 ----------DLSQ-----LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSV 436

Query: 718 RWGDKDIPGSPFMVHV 765
           R   K +  SPF + V
Sbjct: 437 RKSGKHVTNSPFKILV 452

 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 78/255 (30%), Positives = 118/255 (46%), Gaps = 2/255 (0%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
            Y V+F P+E G H V V+   + + GSPF+  VG         V A G GL R V    A
Sbjct: 693  YSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPA 752

Query: 184  HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
             F + T  AG+G L++A++GPSK  +   + ++G    +YV   PG+Y ++I +    HI
Sbjct: 753  EFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDE-HI 811

Query: 361  VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
              SPF                   V   + D R ++      TS  E       GLK   
Sbjct: 812  PDSPFVV----------------PVASLSDDARRLT-----VTSLQE------TGLK--- 841

Query: 541  LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
            +N   SF V  + A  G++   +  P    EE  V  + +++ T+ ++  E+G H I V+
Sbjct: 842  VNQPASFAVQLNGA-RGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVK 900

Query: 721  WGDKDIPGSPFMVHV 765
            +    IPGSPF + V
Sbjct: 901  FNGAHIPGSPFKIRV 915

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 64/258 (24%), Positives = 96/258 (37%), Gaps = 3/258 (1%)
 Frame = +1

Query: 1   GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
           G   V + P   G + + V  + K I GSPF   +     D  M        S+  V   
Sbjct: 331 GTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI---TGDDSM------RTSQLNVGTS 381

Query: 181 AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAP---GNYIINITYGGN 351
               +  T      L  +I  PS     C           ++  P   G +++++   G 
Sbjct: 382 TDVSLKITEGDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGK 441

Query: 352 FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
            H+  SPF  +   ++ GD                             A KV   G GL 
Sbjct: 442 -HVTNSPFKILVGPSEIGD-----------------------------ASKVRVWGKGLS 471

Query: 532 QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
           + +   V  F VD   AGYG L + I GP +   ++    + +    V Y   E GT+II
Sbjct: 472 EGQTFQVAEFIVDTRNAGYGGLGLSIEGPSKV--DINCEDMEDGTCKVTYCPTEPGTYII 529

Query: 712 MVRWGDKDIPGSPFMVHV 765
            +++ DK +PGSPF V V
Sbjct: 530 NIKFADKHVPGSPFTVKV 547

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 70/262 (26%), Positives = 106/262 (40%), Gaps = 7/262 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G  GV +  +E G + V ++ N + I  SPF +PV   + D   +  T    +   V++ 
Sbjct: 786  GSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQP 845

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
            A F V   N   G ++  +  PS     C+ +E   + +   ++    G + I++ + G 
Sbjct: 846  ASFAVQ-LNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNG- 903

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             HI GSPF             V + SQ    A D   VS Y              G GL+
Sbjct: 904  AHIPGSPF----------KIRVGEQSQ----AGDPGLVSAY--------------GPGLE 935

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
                   + F V+   AG G L V I GP +    C E    HV      V Y     G 
Sbjct: 936  GGTTGVSSEFIVNTQNAGSGALSVTIDGPSKVQLDCRECPEGHV------VTYTPMAPGN 989

Query: 703  HIIMVRW-GDKDIPGSPFMVHV 765
            ++I +++ G + I GSPF   V
Sbjct: 990  YLIAIKYGGPQHIVGSPFKAKV 1011

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 71/275 (25%), Positives = 114/275 (41%), Gaps = 19/275 (6%)
 Frame = +1

Query: 1   GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLS---- 159
           G Y V + P  SG + + ++     I  SPFRI   P G  +     V   G GL     
Sbjct: 15  GTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLG 74

Query: 160 -RAVVDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
            R  + ++    V+   AG G +   +  P  ++++++  E  +G ++  Y A  PG Y+
Sbjct: 75  PRIQIGEETVITVDAKAAGKGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYV 134

Query: 328 INITYGGNFHIVGSPF-TAVCEGTKTGD--TEVEQHSQVEIEASDKRCVSQYAEKTTSYA 498
           I I +GG  HI  SPF    C+     +   E+ Q  Q         C + +A +     
Sbjct: 135 ITIRFGGE-HIPNSPFHVLACDPLPHVEEPAEMLQMRQPYAPLRPGTCPTHWATE----- 188

Query: 499 EKVI-CQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ-- 666
           E V+  + L       N V  F V   +         + G VR P  +    ++ +N+  
Sbjct: 189 EPVVPVEPLESMLRPFNLVIPFTVQKGE---------LTGEVRMPSGKTARPNITDNKDG 239

Query: 667 -FTVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
             TV Y   E G H + +++    IPGSP   +VD
Sbjct: 240 TITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVD 274

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 73/322 (22%), Positives = 115/322 (35%), Gaps = 67/322 (20%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P E GT+++ ++   K + GSPF + V            TGEG  +  + ++
Sbjct: 513  GTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKV------------TGEGRMKESITRR 560

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHE--TEEGYEFTYVATAPGNYIINITYGG-- 348
                   T   +  LN+ I G     ++  E  T      ++  T      I+ T GG  
Sbjct: 561  RQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGET 620

Query: 349  --------NFHIVGSPFTAVC-------------------EG------------TKTGDT 411
                    +  + G PF AV                    EG            + +G T
Sbjct: 621  KREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKT 680

Query: 412  EVEQHSQVEIEASDKRCVSQYA---EKTTSY---------------------AEKVICQG 519
            E  +  + E  A   R V Q       T  Y                     A KV   G
Sbjct: 681  EAAEIVEGEDSAYSVRFVPQEMGPHTVTVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGG 740

Query: 520  LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
             GL++        F +   +AG G L + + GP +   E+      +    V YVV+E G
Sbjct: 741  TGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSK--AEIAFEDRKDGSCGVSYVVQEPG 798

Query: 700  THIIMVRWGDKDIPGSPFMVHV 765
             + + +++ D+ IP SPF+V V
Sbjct: 799  DYEVSIKFNDEHIPDSPFVVPV 820

 Score = 37.7 bits (86), Expect = 0.041
 Identities = 15/40 (37%), Positives = 25/40 (62%)
 Frame = +1

Query: 643 VRHVGNNQFTVDYVVKESGTHIIMVRWGDKDIPGSPFMVH 762
           +R  G+  +TV Y+   SG + I +++G  +IP SPF +H
Sbjct: 9   IRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIH 48
>sp|Q14315|FLNC_HUMAN Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc)
            (Actin-binding-like protein) (ABP-L) (ABP-280-like
            protein)
          Length = 2725

 Score =  228 bits (582), Expect = 1e-59
 Identities = 121/262 (46%), Positives = 163/262 (62%), Gaps = 8/262 (3%)
 Frame = +1

Query: 4    QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
            ++ ++F P E+G H + V+ N   I GSPF+I VG  +   DPG+V A G GL       
Sbjct: 2463 KHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGV 2522

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
             + F VNT NAGSG+L+V IDGPSKV ++C E  EG+  TY   APGNY+I I YGG  H
Sbjct: 2523 SSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQH 2582

Query: 358  IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDKRCVSQYAE-----KTTSYAEKVICQG 519
            IVGSPF A   G + +G   + + S V +E   K   S+ +      K +S A KV+ +G
Sbjct: 2583 IVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRG 2642

Query: 520  LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
             GL QA +   NSF VD S+AG  +++VG+ GP  PCEEV V+H+GN  + V Y VKE G
Sbjct: 2643 PGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKG 2702

Query: 700  THIIMVRWGDKDIPGSPFMVHV 765
             +I++V+WGD+ +PGSPF V V
Sbjct: 2703 DYILIVKWGDESVPGSPFKVKV 2724

 Score =  127 bits (320), Expect = 3e-29
 Identities = 87/257 (33%), Positives = 120/257 (46%), Gaps = 2/257 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y V++T  E G H+V V  ++  +  SPFR+ V     DP  V A G GL   +V+K 
Sbjct: 1310 GTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTE-GCDPTRVRAFGPGLEGGLVNKA 1368

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
              F V T  AG+G L +AI+GPS+  M+C + ++G     Y+   PG+Y +NIT+GG   
Sbjct: 1369 NRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGR-P 1427

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL-KQ 534
            I GSPF                               +   K      KV C G GL   
Sbjct: 1428 IPGSPF-------------------------------RVPVKDVVDPGKVKCSGPGLGAG 1456

Query: 535  ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
             R     +F VD SQAG   L V + GP    E V VR  G+   TV Y     G + + 
Sbjct: 1457 VRARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVA 1516

Query: 715  VRWGDKDIPGSPFMVHV 765
            V++ D+++P SPF + V
Sbjct: 1517 VKYADQEVPRSPFKIKV 1533

 Score =  106 bits (265), Expect = 7e-23
 Identities = 58/130 (44%), Positives = 77/130 (59%), Gaps = 2/130 (1%)
 Frame = +1

Query: 10   GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
            G+ FTP+E G H+V V  + K +  SPF+I VG     D   V   G+GLS     + A 
Sbjct: 2002 GISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAE 2061

Query: 187  FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
            F V+T NAG G L ++I+GPSKV++NC + E+G  + TY  T PG YIINI +    H+ 
Sbjct: 2062 FIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADK-HVP 2120

Query: 364  GSPFTAVCEG 393
            GSPFT    G
Sbjct: 2121 GSPFTVKVTG 2130

 Score =  103 bits (258), Expect = 5e-22
 Identities = 70/252 (27%), Positives = 110/252 (43%), Gaps = 1/252 (0%)
 Frame = +1

Query: 13   VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFF 192
            V++ P E G + V +  +  P+ GSPF +  G    DP  V A G GL   +V   A F 
Sbjct: 1026 VRYMPPEEGPYKVDITYDGHPVPGSPFAVE-GVLPPDPSKVCAYGPGLKGGLVGTPAPFS 1084

Query: 193  VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGS 369
            ++T  AG+G L + ++GP +  + C +  +G    +Y+ T PG Y INI +    HI GS
Sbjct: 1085 IDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILF-AEAHIPGS 1143

Query: 370  PFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNS 549
            PF A                                 +      KV   G GL++ ++  
Sbjct: 1144 PFKATI-------------------------------RPVFDPSKVRASGPGLERGKVGE 1172

Query: 550  VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGD 729
              +F VD S+AG   L + I        EV++ +  +  + + Y     GT+ I +++G 
Sbjct: 1173 AATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGG 1232

Query: 730  KDIPGSPFMVHV 765
              +P  P  VHV
Sbjct: 1233 HPVPKFPTRVHV 1244

 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 74/256 (28%), Positives = 113/256 (44%), Gaps = 1/256 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V++ P E G H + ++ +   I GSP +  V   N+    V A G GLS  +V+K 
Sbjct: 1820 GTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRH--VSAYGPGLSHGMVNKP 1877

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
            A F + T +AG G L++A++GPSK  + C + ++G    +Y+ TAPG+Y I + +    H
Sbjct: 1878 ATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDK-H 1936

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            I GSPFTA                  +I   D    SQ    T++     I +       
Sbjct: 1937 IPGSPFTA------------------KITGDDSMRTSQLNVGTSTDVSLKITES------ 1972

Query: 538  RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
                      D SQ     L   I  P    E  +++ + N    + +  KE G H++ V
Sbjct: 1973 ----------DLSQ-----LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSV 2017

Query: 718  RWGDKDIPGSPFMVHV 765
            R   K +  SPF + V
Sbjct: 2018 RKSGKHVTNSPFKILV 2033

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 77/255 (30%), Positives = 117/255 (45%), Gaps = 2/255 (0%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
            Y V+F P+E G H V V+   + + GSPF+  VG         V A   GL R V    A
Sbjct: 2274 YSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGRAGLERGVAGVPA 2333

Query: 184  HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
             F + T  AG+G L++A++GPSK  +   + ++G    +YV   PG+Y ++I +    HI
Sbjct: 2334 EFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDE-HI 2392

Query: 361  VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
              SPF                   V   + D R ++      TS  E       GLK   
Sbjct: 2393 PDSPFVV----------------PVASLSDDARRLT-----VTSLQE------TGLK--- 2422

Query: 541  LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
            +N   SF V  + A  G++   +  P    EE  V  + +++ T+ ++  E+G H I V+
Sbjct: 2423 VNQPASFAVQLNGA-RGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVK 2481

Query: 721  WGDKDIPGSPFMVHV 765
            +    IPGSPF + V
Sbjct: 2482 FNGAHIPGSPFKIRV 2496

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 73/260 (28%), Positives = 108/260 (41%), Gaps = 6/260 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V++ P   G + V +    +PI GSPFR+PV     DPG V  +G GL   V  + 
Sbjct: 1403 GSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDV-VDPGKVKCSGPGLGAGVRARV 1461

Query: 181  AHFF-VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGG 348
               F V+ + AG   L VA+ GP+ V       + G   +   Y     G Y + + Y  
Sbjct: 1462 PQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYAD 1521

Query: 349  NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
               +  SPF                     + A D              A KV   G GL
Sbjct: 1522 Q-EVPRSPFKIKV-----------------LPAHD--------------ASKVRASGPGL 1549

Query: 529  KQARLNSVN--SFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
              + + +     F +DA  AG G+L V I GP    ++  +R  G+  + V Y+   SG 
Sbjct: 1550 NASGIPASLPVEFTIDARDAGEGLLTVQILGPEGKPKKANIRDNGDGTYAVSYLPDMSGR 1609

Query: 703  HIIMVRWGDKDIPGSPFMVH 762
            + I +++G  +IP SPF +H
Sbjct: 1610 YTITIKYGGDEIPYSPFRIH 1629

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 72/263 (27%), Positives = 102/263 (38%), Gaps = 7/263 (2%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRA--VVDKK 180
            Y V + P+ +G H V V    + I  SPF + VG    D   V A G GL     V +K 
Sbjct: 336  YAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVGNVANKP 395

Query: 181  AHFFVNTTNAGSGSLNVAIDGPS----KVNMNCHETEEG-YEFTYVATAPGNYIINITYG 345
             +F + T  AG+G + V I  P      V +   +  +  +  TY     G + +++ + 
Sbjct: 396  TYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAFA 455

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G   I  SPF                                 +E     A +   +GL 
Sbjct: 456  GA-PITRSPFPV-----------------------------HVSEACNPNACRASGRGLQ 485

Query: 526  LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
             K  R+  V  F V    AG G L V + GP    E V VR  G+  F  +Y     G +
Sbjct: 486  PKGVRVKEVADFKVFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKY 545

Query: 706  IIMVRWGDKDIPGSPFMVHVD*E 774
            ++ + WG   IP SPF V V  E
Sbjct: 546  VVTITWGGYAIPRSPFEVQVSPE 568

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 75/254 (29%), Positives = 99/254 (38%), Gaps = 5/254 (1%)
 Frame = +1

Query: 19   FTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK--AHFF 192
            + P   G H V V     PI  SPF + V     +P    A+G GL    V  K  A F 
Sbjct: 440  YRPAMEGPHTVHVAFAGAPITRSPFPVHVSEA-CNPNACRASGRGLQPKGVRVKEVADFK 498

Query: 193  VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGGNFHIV 363
            V T  AGSG L V + GP          E G   +E  Y    PG Y++ IT+GG + I 
Sbjct: 499  VFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGG-YAIP 557

Query: 364  GSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARL 543
             SPF                  QV  EA                 +KV   G GL+  ++
Sbjct: 558  RSPFEV----------------QVSPEAG---------------VQKVRAWGPGLETGQV 586

Query: 544  NSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRW 723
                 F V+A     G L   I GP +   ++     G+    V Y   E G + + V  
Sbjct: 587  GKSADFVVEAIGTEVGTLGFSIEGPSQ--AKIECDDKGDGSCDVRYWPTEPGEYAVHVIC 644

Query: 724  GDKDIPGSPFMVHV 765
             D+DI  SPF+ H+
Sbjct: 645  DDEDIRDSPFIAHI 658

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 78/272 (28%), Positives = 116/272 (42%), Gaps = 16/272 (5%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNAD--PGMVHATGEGL--SRAV 168
            G   V++ P E G + V V  + + I  SPF   +     D  P  V A G GL  +  +
Sbjct: 624  GSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCI 683

Query: 169  VDKKAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINIT 339
            VDK A F ++   AG G L +         ++      G   +  +YV T P  + I I+
Sbjct: 684  VDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGNGTFRCSYVPTKPIKHTIIIS 743

Query: 340  YGGNFHIVGSPFTA-VCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
            +GG  ++  SPF   V EG                                S+ E+V   
Sbjct: 744  WGG-VNVPKSPFRVNVGEG--------------------------------SHPERVKVY 770

Query: 517  GLGLKQARL--NSVNSFFVDASQAGYGILLVGI---AGPVRPCEEVV---VRHVGNNQFT 672
            G G+++  L  N    F VD S+AG G + +GI    G V P E  +   +    N+ FT
Sbjct: 771  GPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFT 830

Query: 673  VDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
            V Y    +G + IMV + +++IP SPF + VD
Sbjct: 831  VKYTPPGAGRYTIMVLFANQEIPASPFHIKVD 862

 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 71/261 (27%), Positives = 99/261 (37%), Gaps = 6/261 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P E G + + +   +  I GSPF+  +     DP  V A+G GL R  V + 
Sbjct: 1115 GSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPV-FDPSKVRASGPGLERGKVGEA 1173

Query: 181  AHFFVNTTNAGSGSLNVAI--DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGN 351
            A F V+ + AG   L + I  D   K  +  H   +G Y  TY    PG Y I I YGG 
Sbjct: 1174 ATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGG- 1232

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             H V    T V             H Q  ++ S                 KV   G+   
Sbjct: 1233 -HPVPKFPTRV-------------HVQPAVDTS---------------GVKVSGPGVEPH 1263

Query: 532  QARLNSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
                     F VDA   +  G   +   +  P     +  V   G+  + V Y   E G 
Sbjct: 1264 GVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGV 1323

Query: 703  HIIMVRWGDKDIPGSPFMVHV 765
            H++ V + +  +P SPF V V
Sbjct: 1324 HLVEVLYDEVAVPKSPFRVGV 1344

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 68/259 (26%), Positives = 105/259 (40%), Gaps = 4/259 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G +  ++ P   G ++V +      I  SPF + V    A    V A G GL    V K 
Sbjct: 531  GVFECEYYPVVPGKYVVTITWGGYAIPRSPFEVQVSP-EAGVQKVRAWGPGLETGQVGKS 589

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
            A F V       G+L  +I+GPS+  + C +  +G  +  Y  T PG Y +++       
Sbjct: 590  ADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEYAVHV------- 642

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
                    +C+     D+    H    I  +   C          + +KV   G GL+  
Sbjct: 643  --------ICDDEDIRDSPFIAH----ILPAPPDC----------FPDKVKAFGPGLEPT 680

Query: 538  R--LNSVNSFFVDASQAGYGILLVGIAGPVRPCE-EVVVRHVGNNQFTVDYVVKESGTHI 708
               ++    F +DA  AG G L +  A     C  ++ V   GN  F   YV  +   H 
Sbjct: 681  GCIVDKPAEFTIDARAAGKGDLKL-YAQDADGCPIDIKVIPNGNGTFRCSYVPTKPIKHT 739

Query: 709  IMVRWGDKDIPGSPFMVHV 765
            I++ WG  ++P SPF V+V
Sbjct: 740  IIISWGGVNVPKSPFRVNV 758

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 68/271 (25%), Positives = 113/271 (41%), Gaps = 15/271 (5%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLS---- 159
            G Y V + P  SG + + ++     I  SPFRI   P G  +     V   G GL     
Sbjct: 1596 GTYAVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLG 1655

Query: 160  -RAVVDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
             R  + ++    V+   AG G +   +  P  ++++++  E  +G ++  Y A  PG Y+
Sbjct: 1656 PRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYV 1715

Query: 328  INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
            I I +GG  HI  SPF  +       + E  +  Q+    +  R       + T +A + 
Sbjct: 1716 ITIRFGGE-HIPNSPFHVLACDPLPHEEEPSEVPQLRQPYAPPRP----GARPTHWATEE 1770

Query: 508  ICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---FTV 675
                +   ++ L   N     A Q G       + G VR P  +    ++ +N+    TV
Sbjct: 1771 PVVPVEPMESMLRPFNLVIPFAVQKGE------LTGEVRMPSGKTARPNITDNKDGTITV 1824

Query: 676  DYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
             Y   E G H + +++    IPGSP   +VD
Sbjct: 1825 RYAPTEKGLHQMGIKYDGNHIPGSPLQFYVD 1855

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 64/258 (24%), Positives = 96/258 (37%), Gaps = 3/258 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P   G + + V  + K I GSPF   +     D  M        S+  V   
Sbjct: 1912 GTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI---TGDDSM------RTSQLNVGTS 1962

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAP---GNYIINITYGGN 351
                +  T +    L  +I  PS     C           ++  P   G +++++   G 
Sbjct: 1963 TDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGK 2022

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             H+  SPF  +   ++ GD                             A KV   G GL 
Sbjct: 2023 -HVTNSPFKILVGPSEIGD-----------------------------ASKVRVWGKGLS 2052

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
            +     V  F VD   AGYG L + I GP +   ++    + +    V Y   E GT+II
Sbjct: 2053 EGHTFQVAEFIVDTRNAGYGGLGLSIEGPSKV--DINCEDMEDGTCKVTYCPTEPGTYII 2110

Query: 712  MVRWGDKDIPGSPFMVHV 765
             +++ DK +PGSPF V V
Sbjct: 2111 NIKFADKHVPGSPFTVKV 2128

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 70/262 (26%), Positives = 106/262 (40%), Gaps = 7/262 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G  GV +  +E G + V ++ N + I  SPF +PV   + D   +  T    +   V++ 
Sbjct: 2367 GSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQP 2426

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
            A F V   N   G ++  +  PS     C+ +E   + +   ++    G + I++ + G 
Sbjct: 2427 ASFAVQ-LNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNG- 2484

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             HI GSPF             V + SQ    A D   VS Y              G GL+
Sbjct: 2485 AHIPGSPF----------KIRVGEQSQ----AGDPGLVSAY--------------GPGLE 2516

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
                   + F V+   AG G L V I GP +    C E    HV      V Y     G 
Sbjct: 2517 GGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHV------VTYTPMAPGN 2570

Query: 703  HIIMVRW-GDKDIPGSPFMVHV 765
            ++I +++ G + I GSPF   V
Sbjct: 2571 YLIAIKYGGPQHIVGSPFKAKV 2592

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 72/262 (27%), Positives = 105/262 (40%), Gaps = 11/262 (4%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
            + VK+TP  +G + + V    + I  SPF I V   + D   V A G GL+R  V+  K 
Sbjct: 829  FTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSH-DASKVKAEGPGLNRTGVEVGKP 887

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMN-----CHETEEGYEFTYVATAPGNYIINITYG 345
             HF V T  AG   L+V   G +K  +          +  Y   Y A   GN  + +TYG
Sbjct: 888  THFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYG 947

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G+  +  SPF             V     +++                    K+  QGL 
Sbjct: 948  GD-PVPKSPFV------------VNVAPPLDL-------------------SKIKVQGLN 975

Query: 526  LKQARLNSVNSFFVDASQA-GYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKE 693
             K A +    +F V+   A G G L V +  P R   PC+  +    G     V Y+  E
Sbjct: 976  SKVA-VGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCK--LEPGGGAEAQAVRYMPPE 1032

Query: 694  SGTHIIMVRWGDKDIPGSPFMV 759
             G + + + +    +PGSPF V
Sbjct: 1033 EGPYKVDITYDGHPVPGSPFAV 1054

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 61/263 (23%), Positives = 103/263 (39%), Gaps = 8/263 (3%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y + ++P   GT+ + ++    P+   P R+ V     D   V  +G G+    V ++
Sbjct: 1210 GTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHV-QPAVDTSGVKVSGPGVEPHGVLRE 1268

Query: 181  A--HFFVNT---TNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINI 336
                F V+    T  G   +   +  PS    + + T+ G   Y   Y A   G +++ +
Sbjct: 1269 VTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEV 1328

Query: 337  TYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
             Y     +  SPF       + G TE    ++V                           
Sbjct: 1329 LYD-EVAVPKSPF-------RVGVTEGCDPTRVR------------------------AF 1356

Query: 517  GLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
            G GL+   +N  N F V+   AG G L + I GP     ++  +   +   TV+Y+    
Sbjct: 1357 GPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEA--KMSCKDNKDGSCTVEYIPFTP 1414

Query: 697  GTHIIMVRWGDKDIPGSPFMVHV 765
            G + + + +G + IPGSPF V V
Sbjct: 1415 GDYDVNITFGGRPIPGSPFRVPV 1437

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 59/272 (21%), Positives = 105/272 (38%), Gaps = 17/272 (6%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVV--D 174
            G +   + P +   H + +      +  SPFR+ VG   + P  V   G G+ +  +  +
Sbjct: 724  GTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNVGE-GSHPERVKVYGPGVEKTGLKAN 782

Query: 175  KKAHFFVNTTNAGSGSLNVAID------GPSKVNMN---CHETEEGYEFTYVATAPGNYI 327
            +  +F V+ + AG G +++ I       GP++ +++        + +   Y     G Y 
Sbjct: 783  EPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYT 842

Query: 328  INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
            I + +  N  I  SPF                   ++++ S               A KV
Sbjct: 843  IMVLFA-NQEIPASPF------------------HIKVDPSHD-------------ASKV 870

Query: 508  ICQGLGLKQA--RLNSVNSFFVDASQAGYGILLVGIAGPVRPCE----EVVVRHVGNNQF 669
              +G GL +    +     F V    AG   L V  AG  +       E++  H  +  +
Sbjct: 871  KAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNH--DYSY 928

Query: 670  TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
            TV Y   + G   + V +G   +P SPF+V+V
Sbjct: 929  TVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNV 960

 Score = 38.5 bits (88), Expect = 0.024
 Identities = 51/256 (19%), Positives = 93/256 (36%), Gaps = 1/256 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P E GT+++ ++   K + GSPF + V            TGEG  +  + ++
Sbjct: 2094 GTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKV------------TGEGRMKESITRR 2141

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFHI 360
                   T   +  LN+ I G     ++  E                  +  T+  + H 
Sbjct: 2142 RQAPSIATIGSTCDLNLKIPGNWFQMVSAQER-----------------LTRTFTRSSHT 2184

Query: 361  VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
                       T+ G+T+ E    V +E S +     +      +          L + R
Sbjct: 2185 YTRTERTEISKTRGGETKPE----VRVEESTQVGGDPFPAVFGDF----------LGRER 2230

Query: 541  LNSVNSFF-VDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
            L S  S       +A    +   +  P    E   +    ++ ++V +V +E G H + V
Sbjct: 2231 LGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAV 2290

Query: 718  RWGDKDIPGSPFMVHV 765
            ++  + +PGSPF   V
Sbjct: 2291 KYRGQHVPGSPFQFTV 2306

 Score = 37.7 bits (86), Expect = 0.041
 Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
 Frame = +1

Query: 559 FFVDASQAGYGILLVGIAGPVRPCEE--VVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
           F V    AG G +LV I  P    EE  VV  +  +  + V YV K +G H + V +  +
Sbjct: 298 FTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQ 357

Query: 733 DIPGSPFMVHV 765
           +I  SPF V+V
Sbjct: 358 NIERSPFEVNV 368
>sp|P21333|FLNA_HUMAN Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding
            protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle
            filamin)
          Length = 2647

 Score =  227 bits (578), Expect = 4e-59
 Identities = 117/260 (45%), Positives = 168/260 (64%), Gaps = 6/260 (2%)
 Frame = +1

Query: 4    QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGH--YNADPGMVHATGEGLSRAVVDK 177
            +Y V+F pre+G +++ V+ N   I GSPF+I VG   +  DPG+V A G GL   V   
Sbjct: 2387 KYAVRFIpreNGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGN 2446

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
             A F VNT+NAG+G+L+V IDGPSKV M+C E  EGY  TY   APG+Y+I+I YGG +H
Sbjct: 2447 PAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYH 2506

Query: 358  IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDK-RCVSQYAEKTTSYAE--KVICQGLG 525
            I GSPF A   G +   +  + + S V +++  K  C  Q+       A+  KV+ +GLG
Sbjct: 2507 IGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGPADASKVVAKGLG 2566

Query: 526  LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
            L +A +   +SF VD S+AG  +LLVG+ GP  PCEE++V+HVG+  ++V Y++K+ G +
Sbjct: 2567 LSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLYSVSYLLKDKGEY 2626

Query: 706  IIMVRWGDKDIPGSPFMVHV 765
             ++V+WG + IPGSP+ V V
Sbjct: 2627 TLVVKWGHEHIPGSPYRVVV 2646

 Score =  132 bits (331), Expect = 2e-30
 Identities = 88/258 (34%), Positives = 121/258 (46%), Gaps = 3/258 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y V++TP E G H V V  +  P+  SPF++PV     DP  V   G G+     +K 
Sbjct: 1315 GMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQVPVTE-GCDPSRVRVHGPGIQSGTTNKP 1373

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
              F V T  AG+G L +A++GPS+  M+C + ++G     Y+    G Y +N+TYGG+  
Sbjct: 1374 NKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGH-Q 1432

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK-- 531
            + GSPF            +V  H   +                   A KV C G GL   
Sbjct: 1433 VPGSPF------------KVPVHDVTD-------------------ASKVKCSGPGLSPG 1461

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
              R N   SF VD S+AG   L V + GP    E V V    +   TV+YV    G + I
Sbjct: 1462 MVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSI 1521

Query: 712  MVRWGDKDIPGSPFMVHV 765
             V +GD+++P SPF V V
Sbjct: 1522 SVLYGDEEVPRSPFKVKV 1539

 Score =  109 bits (272), Expect = 1e-23
 Identities = 72/257 (28%), Positives = 118/257 (45%), Gaps = 2/257 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDK 177
            G  G+ F P+E+G H+V V+ N + +  SP  + +      D   V  +G+GL      +
Sbjct: 2005 GHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFE 2064

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
             A F ++T +AG G L+++I+GPSKV++N  + E+G    TY  T PGNYIINI +    
Sbjct: 2065 PAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQ- 2123

Query: 355  HIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQ 534
            H+ GSPF+       TG+  V++       A     V  + +             L LK 
Sbjct: 2124 HVPGSPFSV----KVTGEGRVKESITRRRRAPSVANVGSHCD-------------LSLKI 2166

Query: 535  ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
              ++  +             +   +  P     E  +    N+ + + +V  E GTH + 
Sbjct: 2167 PEISIQD-------------MTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGTHTVS 2213

Query: 715  VRWGDKDIPGSPFMVHV 765
            V++  + +PGSPF   V
Sbjct: 2214 VKYKGQHVPGSPFQFTV 2230

 Score =  105 bits (263), Expect = 1e-22
 Identities = 75/253 (29%), Positives = 112/253 (44%), Gaps = 1/253 (0%)
 Frame = +1

Query: 13   VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFF 192
            V+F pre G + V V  +  P+ GSPF +        P  V A G GL        A F 
Sbjct: 1031 VRFLpreEGPYEVEVTYDGVPVPGSPFPLEAVA-PTKPSKVKAFGPGLQGGSAGSPARFT 1089

Query: 193  VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGS 369
            ++T  AG+G L + ++GP +  + C +  +G    +YV T PG+Y INI +  + HI GS
Sbjct: 1090 IDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILF-ADTHIPGS 1148

Query: 370  PFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNS 549
            PF A              H     +AS                 KV C G GL++A    
Sbjct: 1149 PFKA--------------HVVPCFDAS-----------------KVKCSGPGLERATAGE 1177

Query: 550  VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGD 729
            V  F VD S AG   L + I        EV ++  G+   T+ Y+    G + + +++G 
Sbjct: 1178 VGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGG 1237

Query: 730  KDIPGSPFMVHVD 768
            + +P  P  + V+
Sbjct: 1238 QPVPNFPSKLQVE 1250

 Score =  100 bits (250), Expect = 4e-21
 Identities = 69/254 (27%), Positives = 114/254 (44%), Gaps = 1/254 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V++ P E+G H + +  +   I GSP +  V + N   G V A G GL+  VV+K 
Sbjct: 1826 GTVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNC--GHVTAYGPGLTHGVVNKP 1883

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
            A F VNT +AG G L++AI+GPSK  ++C + ++G    +Y+   PG+Y I + Y    H
Sbjct: 1884 ATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQ-H 1942

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            + GSPFTA      TGD                                     + +   
Sbjct: 1943 VPGSPFTA----RVTGD-----------------------------------DSMRMSHL 1963

Query: 538  RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
            ++ S     ++ S+    +L   +  P    E  +++ + N    + +V KE+G H++ V
Sbjct: 1964 KVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHV 2023

Query: 718  RWGDKDIPGSPFMV 759
            +   + +  SP  V
Sbjct: 2024 KKNGQHVASSPIPV 2037

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 72/255 (28%), Positives = 115/255 (45%), Gaps = 2/255 (0%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
            Y ++F P E GTH V V+   + + GSPF+  VG         V A G GL RA     A
Sbjct: 2198 YCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPA 2257

Query: 184  HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
             F + T  AG+G L +A++GPSK  ++  + ++G     YV   PG+Y +++ +    HI
Sbjct: 2258 EFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEE-HI 2316

Query: 361  VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
              SPF  V   + +GD                             A ++    L     +
Sbjct: 2317 PDSPF-VVPVASPSGD-----------------------------ARRLTVSSLQESGLK 2346

Query: 541  LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
            +N   SF V  + A  G +   +  P    EE  V  +  +++ V ++ +E+G ++I V+
Sbjct: 2347 VNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGVYLIDVK 2405

Query: 721  WGDKDIPGSPFMVHV 765
            +    IPGSPF + V
Sbjct: 2406 FNGTHIPGSPFKIRV 2420

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 94/325 (28%), Positives = 126/325 (38%), Gaps = 72/325 (22%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK-- 180
            Y   + P   G H V V     PI  SP+ + VG    +P    A G GL    V  K  
Sbjct: 442  YRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA-CNPSACRAVGRGLQPKGVRVKET 500

Query: 181  AHFFVNTTNAGSGSLNVAIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
            A F V T  AGSG L V + GP  +  +   +  +G Y F Y    PG YI+ IT+GG  
Sbjct: 501  ADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQ- 559

Query: 355  HIVGSPFTAVCEGTKTGDTE----------------------------------VEQHSQ 432
            +I  SPF  V  GT+ G+ +                                  VE  SQ
Sbjct: 560  NIGRSPF-EVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQ 618

Query: 433  VEIEASDK---RC-VSQYAEKTTSYAEKVIC----------------------------Q 516
             +IE  DK    C V  + ++   YA  V+C                            +
Sbjct: 619  AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKAR 678

Query: 517  GLGLKQ--ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVK 690
            G GL++    +N    F VDA   G   L V +        E +V+  GN  ++  YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPR 738

Query: 691  ESGTHIIMVRWGDKDIPGSPFMVHV 765
            +   H  MV WG   IP SPF V+V
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNV 763

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 70/272 (25%), Positives = 107/272 (39%), Gaps = 7/272 (2%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGL--SRAVVDKK 180
            + V + P  +GTH V V    + I  SPF + V     D   V A G GL  S  + +K 
Sbjct: 342  FSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKT 401

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-----YEFTYVATAPGNYIINITYG 345
             +F + T  AG+G + V I  P           E      Y  +Y  T  G + +++T+ 
Sbjct: 402  TYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFA 461

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G   I  SP+T                                 +     A + + +GL 
Sbjct: 462  G-VPIPRSPYTVT-----------------------------VGQACNPSACRAVGRGLQ 491

Query: 526  LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
             K  R+     F V    AG G L V + GP +  E V  + +G+  +  +Y     GT+
Sbjct: 492  PKGVRVKETADFKVYTKGAGSGELKVTVKGP-KGEERVKQKDLGDGVYGFEYYPMVPGTY 550

Query: 706  IIMVRWGDKDIPGSPFMVHVD*EIIILTACSN 801
            I+ + WG ++I  SPF      E+ + T C N
Sbjct: 551  IVTITWGGQNIGRSPF------EVKVGTECGN 576

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 70/262 (26%), Positives = 109/262 (41%), Gaps = 7/262 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G  GV +  +E G + V V+ N++ I  SPF +PV   + D   +  +    S   V++ 
Sbjct: 2291 GSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQP 2350

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
            A F V + N   G+++  +  PS     C+ TE   + Y   ++    G Y+I++ + G 
Sbjct: 2351 ASFAV-SLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGVYLIDVKFNGT 2409

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             HI GSPF       + G+              D   VS Y              G GL+
Sbjct: 2410 -HIPGSPFK-----IRVGEPG---------HGGDPGLVSAY--------------GAGLE 2440

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
                 +   F V+ S AG G L V I GP +    C+E          + V Y     G+
Sbjct: 2441 GGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQEC------PEGYRVTYTPMAPGS 2494

Query: 703  HIIMVRWGDK-DIPGSPFMVHV 765
            ++I +++G    I GSPF   V
Sbjct: 2495 YLISIKYGGPYHIGGSPFKAKV 2516

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 69/273 (25%), Positives = 119/273 (43%), Gaps = 17/273 (6%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLSRAV- 168
            G Y V + P  +G + + ++     I  SP+R+   P G  +     V   G GL   + 
Sbjct: 1602 GTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIG 1661

Query: 169  ----VDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
                + ++    V+T  AG G +   +  P  S+V+++  E E+G ++  Y A  PG Y+
Sbjct: 1662 PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYV 1721

Query: 328  INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
            I + +GG  H+  SPF         GD    Q      + + +   +Q  ++T +    +
Sbjct: 1722 ICVRFGGE-HVPNSPFQVTA---LAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPL 1777

Query: 508  I-CQGLGLKQAR-LNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---F 669
            +   GL +   R  + V  F +   +         I G VR P  +V    + +N+    
Sbjct: 1778 VGVNGLDVTSLRPFDLVIPFTIKKGE---------ITGEVRMPSGKVAQPTITDNKDGTV 1828

Query: 670  TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
            TV Y   E+G H + +R+ +  IPGSP   +VD
Sbjct: 1829 TVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVD 1861

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 72/269 (26%), Positives = 110/269 (40%), Gaps = 13/269 (4%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNAD--PGMVHATGEGLSRA--V 168
            G   V++ P+E+G + V V  N + I  SPF   +     D  P  V A G GL +    
Sbjct: 629  GSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTGVA 688

Query: 169  VDKKAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINIT 339
            V+K A F V+  + G   L V +       +     + G   Y  +YV   P  +   ++
Sbjct: 689  VNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAMVS 748

Query: 340  YGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQG 519
            +GG   I  SPF                  +V + A        +  K   Y   V   G
Sbjct: 749  WGG-VSIPNSPF------------------RVNVGAGS------HPNKVKVYGPGVAKTG 783

Query: 520  LGLKQARLNSVNSFFVDASQAGYGILLVGIA---GPVRPCEEVV---VRHVGNNQFTVDY 681
            L     + +    F VD ++AG G + +GI    G V P E  +   +    N+ FTV Y
Sbjct: 784  L-----KAHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKY 838

Query: 682  VVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
              + +G++ IMV + D+  P SP  V V+
Sbjct: 839  TPRGAGSYTIMVLFADQATPTSPIRVKVE 867

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 71/261 (27%), Positives = 108/261 (41%), Gaps = 12/261 (4%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
            + VK+TPR +G++ + V    +    SP R+ V   + D   V A G GLSR  V+  K 
Sbjct: 834  FTVKYTPRGAGSYTIMVLFADQATPTSPIRVKV-EPSHDASKVKAEGPGLSRTGVELGKP 892

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSK------VNMNCHETEEGYEFTYVATAPGNYIINITY 342
             HF VN   AG G L+V   G +K      V++  H  +  Y   Y     G   +N+TY
Sbjct: 893  THFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHH-DNTYTVKYTPVQQGPVGVNVTY 951

Query: 343  GGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGL 522
            GG+  I  SPF+                                A   +    K+   GL
Sbjct: 952  GGD-PIPKSPFSV-------------------------------AVSPSLDLSKIKVSGL 979

Query: 523  GLKQARLNSVNSFFVDASQAG----YGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVK 690
            G ++  +     F V +  AG        +VG +G   PC+  V   +G +   V ++ +
Sbjct: 980  G-EKVDVGKDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCK--VEPGLGADNSVVRFLPR 1036

Query: 691  ESGTHIIMVRWGDKDIPGSPF 753
            E G + + V +    +PGSPF
Sbjct: 1037 EEGPYEVEVTYDGVPVPGSPF 1057

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 67/263 (25%), Positives = 105/263 (39%), Gaps = 8/263 (3%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P E G + + +      I GSPF+  V     D   V  +G GL RA   + 
Sbjct: 1120 GTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPC-FDASKVKCSGPGLERATAGEV 1178

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGGN 351
              F V+ ++AGS  L + I   + +    +  + G   +  TY+   PG Y + I YGG 
Sbjct: 1179 GQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQ 1238

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
              +   P                  S++++E          A  T+     V C G G++
Sbjct: 1239 -PVPNFP------------------SKLQVEP---------AVDTSG----VQCYGPGIE 1266

Query: 532  QARL--NSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
               +   +   F VDA   +Q G   +   +A P     E  V+  G+  + V+Y   E 
Sbjct: 1267 GQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEE 1326

Query: 697  GTHIIMVRWGDKDIPGSPFMVHV 765
            G H + V +    +P SPF V V
Sbjct: 1327 GLHSVDVTYDGSPVPSSPFQVPV 1349

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 67/258 (25%), Positives = 100/258 (38%), Gaps = 5/258 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P   G + + V    + +  SPF++ V   + D   V A+G GL+   V   
Sbjct: 1505 GTQTVNYVPSREGPYSISVLYGDEEVPRSPFKVKVLPTH-DASKVKASGPGLNTTGVPAS 1563

Query: 181  --AHFFVNTTNAGSGSLNVAIDGPSKVNMNCH--ETEEG-YEFTYVATAPGNYIINITYG 345
                F ++  +AG G L V I  P       H  +  +G Y   YV    G Y I I YG
Sbjct: 1564 LPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYG 1623

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G+  I  SP+        TGD                +C       T S     +  G+G
Sbjct: 1624 GD-EIPFSPYRV--RAVPTGDAS--------------KCTV-----TVSIGGHGLGAGIG 1661

Query: 526  LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
                ++       VD   AG G +   +  P     +V V    +  F + Y   + G +
Sbjct: 1662 -PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKY 1720

Query: 706  IIMVRWGDKDIPGSPFMV 759
            +I VR+G + +P SPF V
Sbjct: 1721 VICVRFGGEHVPNSPFQV 1738

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 67/272 (24%), Positives = 107/272 (39%), Gaps = 17/272 (6%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y   + PR+   H   V      I  SPFR+ VG   + P  V   G G+++  +  K
Sbjct: 729  GTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGA-GSHPNKVKVYGPGVAKTGL--K 785

Query: 181  AH----FFVNTTNAGSGSLNVAID------GPSKVNMN---CHETEEGYEFTYVATAPGN 321
            AH    F V+   AG G +++ I       GP++ +++        + +   Y     G+
Sbjct: 786  AHEPTYFTVDCAEAGQGDVSIGIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGS 845

Query: 322  YIINITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAE 501
            Y I + +        +P + +               +V++E S               A 
Sbjct: 846  YTIMVLFADQ----ATPTSPI---------------RVKVEPSHD-------------AS 873

Query: 502  KVICQGLGLKQA--RLNSVNSFFVDASQAGYGILLVGIAGPVR--PCEEVVVRHVGNNQF 669
            KV  +G GL +    L     F V+A  AG G L V  +G  +     +V +    +N +
Sbjct: 874  KVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDIIDHHDNTY 933

Query: 670  TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
            TV Y   + G   + V +G   IP SPF V V
Sbjct: 934  TVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAV 965

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
 Frame = +1

Query: 559 FFVDASQAGYGILLVGIAGPVRPCEE--VVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
           F V+   AG G +LV +  P    EE  V   +  N  F+V YV + +GTH + V +  +
Sbjct: 304 FTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQ 363

Query: 733 DIPGSPFMVHVD 768
            I  SPF V+VD
Sbjct: 364 HIAKSPFEVYVD 375

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 26/87 (29%), Positives = 42/87 (48%)
 Frame = +1

Query: 505  VICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYV 684
            V   G GL    +N   +F V+   AG G L + I GP +   E+      +   +V Y+
Sbjct: 1868 VTAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYL 1925

Query: 685  VKESGTHIIMVRWGDKDIPGSPFMVHV 765
                G + I+V++ ++ +PGSPF   V
Sbjct: 1926 PVLPGDYSILVKYNEQHVPGSPFTARV 1952
>sp|Q8BTM8|FLNA_MOUSE Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding
            protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle
            filamin)
          Length = 2647

 Score =  227 bits (578), Expect = 4e-59
 Identities = 116/260 (44%), Positives = 170/260 (65%), Gaps = 6/260 (2%)
 Frame = +1

Query: 4    QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGH--YNADPGMVHATGEGLSRAVVDK 177
            +Y V+F pre+G +++ V+ N   I GSPF+I VG   +  DPG+V A G GL   V   
Sbjct: 2387 KYAVRFIpreNGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGS 2446

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
             A F VNT+NAG+G+L+V IDGPSKV M+C E  EGY  TY   APG+Y+I+I YGG +H
Sbjct: 2447 PAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYH 2506

Query: 358  IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEASDK-RCVSQYAEKTTSYAE--KVICQGLG 525
            I GSPF A   G +   +  + + S V +++  K   V Q+A      A+  KV+ +GLG
Sbjct: 2507 IGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKVATVPQHATSGPGPADVSKVVAKGLG 2566

Query: 526  LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
            L +A +   ++F VD S+AG  +LLVG+ GP  PCEE++V+H+G+  ++V Y++K+ G +
Sbjct: 2567 LSKAYVGQKSNFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHMGSRLYSVSYLLKDKGEY 2626

Query: 706  IIMVRWGDKDIPGSPFMVHV 765
             ++V+WGD+ IPGSP+ + V
Sbjct: 2627 TLVVKWGDEHIPGSPYRIMV 2646

 Score =  131 bits (329), Expect = 3e-30
 Identities = 87/258 (33%), Positives = 122/258 (47%), Gaps = 3/258 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y V++TP E G H V V  +  P+  SPF++PV     DP  V   G G+     +K 
Sbjct: 1315 GTYKVEYTPYEEGVHSVDVTYDGSPVPSSPFQVPVTE-GCDPSRVRVHGPGIQSGTTNKP 1373

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
              F V T  AG+G L +A++GPS+  M+C + ++G     Y+    G Y +N+TYGG+  
Sbjct: 1374 NKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGH-Q 1432

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK-- 531
            + GSPF            +V  H   +                   A KV C G GL   
Sbjct: 1433 VPGSPF------------KVPVHDVTD-------------------ASKVKCSGPGLSPG 1461

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
              R N   SF VD S+AG   L V + GP    E V V    +   TV+YV    G++ I
Sbjct: 1462 MVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGSYSI 1521

Query: 712  MVRWGDKDIPGSPFMVHV 765
             V +G++++P SPF V V
Sbjct: 1522 SVLYGEEEVPRSPFKVKV 1539

 Score =  106 bits (265), Expect = 7e-23
 Identities = 70/257 (27%), Positives = 117/257 (45%), Gaps = 2/257 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDK 177
            G  G+ F P+E+G H+V V+ N + +  SP  + +      D   V  +G+GL      +
Sbjct: 2005 GHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFE 2064

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
             A F ++T +AG G L+++I+GPSKV++N  + E+G    TY  T PGNYIINI +    
Sbjct: 2065 PAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQ- 2123

Query: 355  HIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQ 534
            H+ GSPF+       TG+  V++       A     +  + +             L LK 
Sbjct: 2124 HVPGSPFSV----KVTGEGRVKESITRRRRAPSVANIGSHCD-------------LSLKI 2166

Query: 535  ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
              ++  +             +   +  P     E  +    N+ + + +V  E G H + 
Sbjct: 2167 PEISIQD-------------MTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVS 2213

Query: 715  VRWGDKDIPGSPFMVHV 765
            V++  + +PGSPF   V
Sbjct: 2214 VKYKGQHVPGSPFQFTV 2230

 Score =  106 bits (264), Expect = 9e-23
 Identities = 75/253 (29%), Positives = 112/253 (44%), Gaps = 1/253 (0%)
 Frame = +1

Query: 13   VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFF 192
            V+F pre G + V V  +  P+ GSPF +        P  V A G GL        A F 
Sbjct: 1031 VRFVpreEGPYEVEVTYDGVPVPGSPFPLEAVA-PTKPSKVKAFGPGLQGGNAGSPARFT 1089

Query: 193  VNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGS 369
            ++T  AG+G L + ++GP +  + C +  +G    +YV T PG+Y INI +  + HI GS
Sbjct: 1090 IDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILF-ADTHIPGS 1148

Query: 370  PFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNS 549
            PF A              H     +AS                 KV C G GL++A    
Sbjct: 1149 PFKA--------------HVAPCFDAS-----------------KVKCSGPGLERATAGE 1177

Query: 550  VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGD 729
            V  F VD S AG   L + I        EV ++  G+   T+ Y+    G + + +++G 
Sbjct: 1178 VGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGG 1237

Query: 730  KDIPGSPFMVHVD 768
            + +P  P  + V+
Sbjct: 1238 QPVPNFPSKLQVE 1250

 Score =  101 bits (252), Expect = 2e-21
 Identities = 69/254 (27%), Positives = 115/254 (45%), Gaps = 1/254 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V+++P E+G H + +  +   I GSP +  V + N   G + A G GL+  VV+K 
Sbjct: 1826 GTVTVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNC--GHITAYGPGLTHGVVNKP 1883

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
            A F VNT +AG G L++AI+GPSK  ++C + ++G    +Y+   PG+Y I + Y    H
Sbjct: 1884 ATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNDQ-H 1942

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            I GSPFTA      TGD                                     + +   
Sbjct: 1943 IPGSPFTA----RVTGD-----------------------------------DSMRMSHL 1963

Query: 538  RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
            ++ S     ++ S+    +L   +  P    E  +++ + N    + +V KE+G H++ V
Sbjct: 1964 KVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHV 2023

Query: 718  RWGDKDIPGSPFMV 759
            +   + +  SP  V
Sbjct: 2024 KKNGQHVASSPIPV 2037

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 71/255 (27%), Positives = 114/255 (44%), Gaps = 2/255 (0%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKA 183
            Y ++F P E G H V V+   + + GSPF+  VG         V A G GL RA     A
Sbjct: 2198 YCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAGVPA 2257

Query: 184  HFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHI 360
             F + T  AG+G L +A++GPSK  ++  + ++G     YV   PG+Y +++ +    HI
Sbjct: 2258 EFGIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEE-HI 2316

Query: 361  VGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQAR 540
              SPF  V   + +GD                             A ++    L     +
Sbjct: 2317 PDSPF-VVPVASPSGD-----------------------------ARRLTVSSLQESGLK 2346

Query: 541  LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVR 720
            +N   SF V  + A  G +   +  P    EE  V  +  +++ V ++ +E+G ++I V+
Sbjct: 2347 VNQPASFAVSLNGA-KGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGIYLIDVK 2405

Query: 721  WGDKDIPGSPFMVHV 765
            +    IPGSPF + V
Sbjct: 2406 FNGTHIPGSPFKIRV 2420

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 95/325 (29%), Positives = 126/325 (38%), Gaps = 72/325 (22%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK-- 180
            Y   + P   G H V V     PI  SP+ + VG    +P    A G GL    V  K  
Sbjct: 442  YRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQA-CNPAACRAIGRGLQPKGVRVKET 500

Query: 181  AHFFVNTTNAGSGSLNVAIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNF 354
            A F V T  AGSG L V + GP  +  +   +  +G Y F Y  T PG Y + IT+GG  
Sbjct: 501  ADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQ- 559

Query: 355  HIVGSPFTAVCEGTKTGDTE----------------------------------VEQHSQ 432
            +I  SPF  V  GT+ G+ +                                  VE  SQ
Sbjct: 560  NIGRSPF-EVKVGTECGNQKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQ 618

Query: 433  VEIEASDK---RC-VSQYAEKTTSYAEKVIC----------------------------Q 516
             +IE  DK    C V  + ++   YA  V+C                            +
Sbjct: 619  AKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKAR 678

Query: 517  GLGLKQ--ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVK 690
            G GL++    +N    F VDA  AG   L V +        E  V+  GN  ++  YV +
Sbjct: 679  GPGLEKTGVAVNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPR 738

Query: 691  ESGTHIIMVRWGDKDIPGSPFMVHV 765
            +   H  MV WG   IP SPF V+V
Sbjct: 739  KPVKHTAMVSWGGVSIPNSPFRVNV 763

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 70/272 (25%), Positives = 106/272 (38%), Gaps = 7/272 (2%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGL--SRAVVDKK 180
            + V + P  +GTH V V    + I  SPF + V     D   V A G GL  S  + +K 
Sbjct: 342  FSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKT 401

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-----YEFTYVATAPGNYIINITYG 345
             +F + T  AG G + V I  P+          E      Y  +Y  T  G + +++T+ 
Sbjct: 402  TYFEIFTAGAGMGEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFA 461

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G   I  SP+T                                 +     A + I +GL 
Sbjct: 462  G-VPIPRSPYTVT-----------------------------VGQACNPAACRAIGRGLQ 491

Query: 526  LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
             K  R+     F V    AG G L V + GP +  E V  + +G+  +  +Y     GT+
Sbjct: 492  PKGVRVKETADFKVYTKGAGSGELKVTVKGP-KGEERVKQKDLGDGVYGFEYYPTIPGTY 550

Query: 706  IIMVRWGDKDIPGSPFMVHVD*EIIILTACSN 801
             + + WG ++I  SPF      E+ + T C N
Sbjct: 551  TVTITWGGQNIGRSPF------EVKVGTECGN 576

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 7/262 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G  GV +  +E G + V V+ N++ I  SPF +PV   + D   +  +    S   V++ 
Sbjct: 2291 GSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQP 2350

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
            A F V + N   G+++  +  PS     C+ TE   + Y   ++    G Y+I++ + G 
Sbjct: 2351 ASFAV-SLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIpreNGIYLIDVKFNGT 2409

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             HI GSPF       + G+              D   VS Y              G GL+
Sbjct: 2410 -HIPGSPFK-----IRVGEPG---------HGGDPGLVSAY--------------GAGLE 2440

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
                 S   F V+ S AG G L V I GP +    C+E          + V Y     G+
Sbjct: 2441 GGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQEC------PEGYRVTYTPMAPGS 2494

Query: 703  HIIMVRWGDK-DIPGSPFMVHV 765
            ++I +++G    I GSPF   V
Sbjct: 2495 YLISIKYGGPYHIGGSPFKAKV 2516

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 73/269 (27%), Positives = 111/269 (41%), Gaps = 13/269 (4%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNAD--PGMVHATGEGLSRA--V 168
            G   V++ P+E+G + V V  N + I  SPF   +     D  P  V A G GL +    
Sbjct: 629  GSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVA 688

Query: 169  VDKKAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINIT 339
            V+K A F V+  +AG   L V +      ++     + G   Y  +YV   P  +   ++
Sbjct: 689  VNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPRKPVKHTAMVS 748

Query: 340  YGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQG 519
            +GG   I  SPF                  +V + A        +  K   Y   V   G
Sbjct: 749  WGG-VSIPNSPF------------------RVNVGAGS------HPNKVKVYGPGVAKTG 783

Query: 520  LGLKQARLNSVNSFFVDASQAGYGILLVGIA---GPVRPCEEVV---VRHVGNNQFTVDY 681
            L     + +    F VD ++AG G + +GI    G V P E  +   +    N+ FTV Y
Sbjct: 784  L-----KAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKY 838

Query: 682  VVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
                +G++ IMV + D+  P SP  V V+
Sbjct: 839  TPCGAGSYTIMVLFADQATPTSPIRVKVE 867

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 68/258 (26%), Positives = 103/258 (39%), Gaps = 5/258 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P   G++ + V   ++ +  SPF++ V   + D   V A+G GL+   V   
Sbjct: 1505 GTQTVNYVPSREGSYSISVLYGEEEVPRSPFKVKVLPTH-DASKVKASGPGLNTTGVPAS 1563

Query: 181  --AHFFVNTTNAGSGSLNVAIDGPSKVNMNCH--ETEEG-YEFTYVATAPGNYIINITYG 345
                F ++  +AG G L V I  P       H  +  +G Y   YV   PG Y I I YG
Sbjct: 1564 LPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVPGRYTILIKYG 1623

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G+  I  SP+        TGD                +C       T S     +  G+G
Sbjct: 1624 GD-EIPFSPYRV--RAVPTGDAS--------------KCTV-----TVSIGGHGLGAGIG 1661

Query: 526  LKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTH 705
                ++       VD   AG G +   +  P     +V V    +  F + Y   + G +
Sbjct: 1662 -PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKY 1720

Query: 706  IIMVRWGDKDIPGSPFMV 759
            +I VR+G + +P SPF V
Sbjct: 1721 VICVRFGGEHVPNSPFQV 1738

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 66/263 (25%), Positives = 105/263 (39%), Gaps = 8/263 (3%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P E G + + +      I GSPF+  V     D   V  +G GL RA   + 
Sbjct: 1120 GTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVAPC-FDASKVKCSGPGLERATAGEV 1178

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINITYGGN 351
              F V+ ++AGS  L + I   + +    +  + G   +  TY+   PG Y + I YGG 
Sbjct: 1179 GQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQ 1238

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
              +   P                  S++++E          A  T+     V C G G++
Sbjct: 1239 -PVPNFP------------------SKLQVEP---------AVDTSG----VQCYGPGIE 1266

Query: 532  QARL--NSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
               +   +   F VDA   +Q G   +   +A P     +  V+  G+  + V+Y   E 
Sbjct: 1267 GQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVEYTPYEE 1326

Query: 697  GTHIIMVRWGDKDIPGSPFMVHV 765
            G H + V +    +P SPF V V
Sbjct: 1327 GVHSVDVTYDGSPVPSSPFQVPV 1349

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 69/273 (25%), Positives = 117/273 (42%), Gaps = 17/273 (6%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRI---PVGHYNADPGMVHATGEGLSRAV- 168
            G Y V + P   G + + ++     I  SP+R+   P G  +     V   G GL   + 
Sbjct: 1602 GTYTVAYVPDVPGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIG 1661

Query: 169  ----VDKKAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYI 327
                + ++    V+T  AG G +   +  P  S+V+++  E E+G ++  Y A  PG Y+
Sbjct: 1662 PTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYV 1721

Query: 328  INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
            I + +GG  H+  SPF         GD    Q      + + +    Q +++T      +
Sbjct: 1722 ICVRFGGE-HVPNSPFQVTA---LAGDQPTVQTPLRSQQLAPQYNYPQGSQQTWIPERPM 1777

Query: 508  I-CQGLGLKQAR-LNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---F 669
            +   GL +   R  + V  F +   +         I G VR P  +V    + +N+    
Sbjct: 1778 VGVNGLDVTSLRPFDLVIPFTIKKGE---------ITGEVRMPSGKVAQPSITDNKDGTV 1828

Query: 670  TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
            TV Y   E+G H + +R+ +  IPGSP   +VD
Sbjct: 1829 TVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVD 1861

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 68/272 (25%), Positives = 109/272 (40%), Gaps = 17/272 (6%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y   + PR+   H   V      I  SPFR+ VG   + P  V   G G+++  +  K
Sbjct: 729  GTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGA-GSHPNKVKVYGPGVAKTGL--K 785

Query: 181  AH----FFVNTTNAGSGSLNVAID------GPSKVNMN---CHETEEGYEFTYVATAPGN 321
            AH    F V+ T AG G +++ I       GP++ +++        + +   Y     G+
Sbjct: 786  AHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGS 845

Query: 322  YIINITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAE 501
            Y I + +        +P + +               +V++E S               A 
Sbjct: 846  YTIMVLFADQ----ATPTSPI---------------RVKVEPSHD-------------AS 873

Query: 502  KVICQGLGLKQA--RLNSVNSFFVDASQAGYGILLVGIAGPVR--PCEEVVVRHVGNNQF 669
            KV  +G GL +    L     F V+A  AG G L V  +G  +     +V +    +N +
Sbjct: 874  KVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGLAKGDAVRDVDIIDHHDNTY 933

Query: 670  TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
            TV Y+  + G   + V +G   IP SPF V V
Sbjct: 934  TVKYIPVQQGPVGVNVTYGGDHIPKSPFSVGV 965

 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 27/87 (31%), Positives = 42/87 (48%)
 Frame = +1

Query: 505  VICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYV 684
            +   G GL    +N   +F V+   AG G L + I GP +   E+      +   +V Y+
Sbjct: 1868 ITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKA--EISCTDNQDGTCSVSYL 1925

Query: 685  VKESGTHIIMVRWGDKDIPGSPFMVHV 765
                G + I+V++ D+ IPGSPF   V
Sbjct: 1926 PVLPGDYSILVKYNDQHIPGSPFTARV 1952

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 27/72 (37%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
 Frame = +1

Query: 559 FFVDASQAGYGILLVGIAGPVRPCEE--VVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
           F V+   AG G +LV +  P    EE  V   +  N  F+V YV + +GTH + V +  +
Sbjct: 304 FTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQ 363

Query: 733 DIPGSPFMVHVD 768
            I  SPF V+VD
Sbjct: 364 HIAKSPFEVYVD 375
>sp|O75369|FLNB_HUMAN Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
            (Thyroid autoantigen) (Truncated actin-binding protein)
            (Truncated ABP) (ABP-280 homolog) (ABP-278) (Filamin 3)
            (Filamin homolog 1) (Fh1)
          Length = 2602

 Score =  225 bits (574), Expect = 1e-58
 Identities = 117/261 (44%), Positives = 162/261 (62%), Gaps = 7/261 (2%)
 Frame = +1

Query: 4    QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
            +Y V+F P E+G H + V+ N   + GSPF++ VG      +P +V A G GL       
Sbjct: 2342 KYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTGI 2401

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
            ++ FF+NTT AG G+L+V I+GPSKV M+C ET EGY+  Y   APGNY+I++ YGG  H
Sbjct: 2402 QSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPNH 2461

Query: 358  IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEA----SDKRCVSQYAEKTTSYAEKVICQGL 522
            IVGSPF A   G +        + S + +E+    S + C S    K +S A KV  +G 
Sbjct: 2462 IVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIP-KASSDASKVTSKGA 2520

Query: 523  GLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
            GL +A +   +SF VD S+AG  +LL+G+ GP  PCEEV ++HVGN Q+ V YVVKE G 
Sbjct: 2521 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGD 2580

Query: 703  HIIMVRWGDKDIPGSPFMVHV 765
            +++ V+WG++ IPGSPF V V
Sbjct: 2581 YVLAVKWGEEHIPGSPFHVTV 2601

 Score =  129 bits (325), Expect = 8e-30
 Identities = 89/256 (34%), Positives = 125/256 (48%), Gaps = 1/256 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y V++TP E G H+V V  +  PI  SPF++ V      P  V A G GL  A  +K 
Sbjct: 1288 GTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTE-GCQPSRVQAQGPGLKEAFTNKP 1346

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
              F V T  AG G L + ++GPS+  +NC + ++G     Y+  APG+Y +NITYGG  H
Sbjct: 1347 NVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGG-AH 1405

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            I GSPF    +       +V   S+V                      K+   GLG    
Sbjct: 1406 IPGSPFRVPVK-------DVVDPSKV----------------------KIAGPGLG-SGV 1435

Query: 538  RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
            R   + SF VD+S+AG   L V + GP    E V +   G+   TV Y   + G +++ V
Sbjct: 1436 RARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNMVDNGDGTHTVTYTPSQEGPYMVSV 1495

Query: 718  RWGDKDIPGSPFMVHV 765
            ++ D++IP SPF V V
Sbjct: 1496 KYADEEIPRSPFKVKV 1511

 Score =  102 bits (253), Expect = 2e-21
 Identities = 71/256 (27%), Positives = 112/256 (43%), Gaps = 1/256 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V++ P E G H + ++     I  SP +  V + N+  G V A G GL   V +K 
Sbjct: 1782 GTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNS--GSVSAYGPGLVYGVANKT 1839

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGY-EFTYVATAPGNYIINITYGGNFH 357
            A F + T +AG G L++AI+GPSK  ++C + ++G    TY+ T PG+Y I + Y    H
Sbjct: 1840 ATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDK-H 1898

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            I GSPFTA                  +I    +RC                       Q 
Sbjct: 1899 IPGSPFTA------------------KITDDSRRC----------------------SQV 1918

Query: 538  RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
            +L S   F +D S+     L   I  P    E  +++ + NN   + ++ +E G H++ +
Sbjct: 1919 KLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSI 1978

Query: 718  RWGDKDIPGSPFMVHV 765
            +     +  SP  + V
Sbjct: 1979 KKNGNHVANSPVSIMV 1994

 Score =  101 bits (252), Expect = 2e-21
 Identities = 70/252 (27%), Positives = 113/252 (44%), Gaps = 1/252 (0%)
 Frame = +1

Query: 16   KFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFFV 195
            KF pre G + V V  +  P+ GSP+ +       DP  V A G GL   +V K A F +
Sbjct: 1005 KFIpreEGLYAVDVTYDGHPVPGSPYTVEAS-LPPDPSKVKAHGPGLEGGLVGKPAEFTI 1063

Query: 196  NTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGSP 372
            +T  AG+G L + ++GP +  + C +  +G    +Y+ T PG Y +NI +    HI GSP
Sbjct: 1064 DTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILF-EEVHIPGSP 1122

Query: 373  FTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNSV 552
            F A  E              +  + S                 KV+  G GL+  ++   
Sbjct: 1123 FKADIE--------------MPFDPS-----------------KVVASGPGLEHGKVGEA 1151

Query: 553  NSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
                V+ S+AG G L +          EV +++  +  + V YV   +G + + +++G +
Sbjct: 1152 GLLSVNCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGE 1211

Query: 733  DIPGSPFMVHVD 768
             +P  P  V V+
Sbjct: 1212 LVPHFPARVKVE 1223

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 69/254 (27%), Positives = 111/254 (43%), Gaps = 2/254 (0%)
 Frame = +1

Query: 10   GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
            G+ F pre G H+V ++ N   +  SP  I V      D       G GLS     + + 
Sbjct: 1963 GISFIpreVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSD 2022

Query: 187  FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
            F V+T +AG G +++A++GPSKV++   + E+G  + +Y  T PG YI++  +    H+ 
Sbjct: 2023 FIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADE-HVP 2081

Query: 364  GSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARL 543
            GSPFT    G                E   K  +++ +   +      IC  L LK   +
Sbjct: 2082 GSPFTVKISG----------------EGRVKESITRTSRAPSVATVGSICD-LNLKIPEI 2124

Query: 544  NSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRW 723
            NS +             +   +  P     E  +  +G N   V +V +E G H + V++
Sbjct: 2125 NSSD-------------MSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKY 2171

Query: 724  GDKDIPGSPFMVHV 765
              + + GSPF   V
Sbjct: 2172 RGQHVTGSPFQFTV 2185

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 70/253 (27%), Positives = 109/253 (43%), Gaps = 2/253 (0%)
 Frame = +1

Query: 13   VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKAHF 189
            V+F P+E G H V V+   + + GSPF+  VG         V A G GL R      A F
Sbjct: 2155 VRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEF 2214

Query: 190  FVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVG 366
             + T  AG+G L++A++GPSK  +   + + G    +Y+A  PGNY ++I +    HI  
Sbjct: 2215 SIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPE 2273

Query: 367  SPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLN 546
            SP+                     I  SD              A ++    L     ++N
Sbjct: 2274 SPYLVPV-----------------IAPSDD-------------ARRLTVMSLQESGLKVN 2303

Query: 547  SVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWG 726
               SF +  + A  G +   +  P    EE  V  +  +++ V ++  E+G H I V++ 
Sbjct: 2304 QPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFN 2362

Query: 727  DKDIPGSPFMVHV 765
               + GSPF V V
Sbjct: 2363 GSHVVGSPFKVRV 2375

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 77/260 (29%), Positives = 111/260 (42%), Gaps = 7/260 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G + V +TP + G +MV V+   + I  SPF++ V     D   V A+G GLS   V   
Sbjct: 1477 GTHTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKV-LPTYDASKVTASGPGLSSYGVPAS 1535

Query: 181  --AHFFVNTTNAGSGSLNVAI---DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITY 342
                F ++  +AG G L V I   +G  K     H+ ++G Y  TY+    G Y+I +TY
Sbjct: 1536 LPVDFAIDARDAGEGLLAVQITDQEGKPK-RAIVHDNKDGTYAVTYIPDKTGRYMIGVTY 1594

Query: 343  GGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGL 522
            GG+  I  SP+      T+TGD                             A K +  G 
Sbjct: 1595 GGD-DIPLSPYR--IRATQTGD-----------------------------ASKCLATGP 1622

Query: 523  GL-KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESG 699
            G+    +      F VDA  AG G +   +  P     E  V    +  + + Y   + G
Sbjct: 1623 GIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPG 1682

Query: 700  THIIMVRWGDKDIPGSPFMV 759
            T++I VR+G  DIP SPF V
Sbjct: 1683 TYVIYVRFGGVDIPNSPFTV 1702

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 69/259 (26%), Positives = 101/259 (38%), Gaps = 6/259 (2%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRA--VVDKK 180
            Y V++ P+ +G H V V    + I+ SPF + V     D   V A G GL     + +K 
Sbjct: 315  YSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAKGPGLEAVGNIANKP 374

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVN----MNCHETEEGYEFTYVATAPGNYIINITYGG 348
             +F + T  AG G + V ++ P   N    +   +  + Y   Y    PG +++ I + G
Sbjct: 375  TYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAG 434

Query: 349  NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
            +  I  SPF                             V Q  E     A +   +GL  
Sbjct: 435  D-TIPKSPF-----------------------------VVQVGEACNPNACRASGRGLQP 464

Query: 529  KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHI 708
            K  R+     F VD   AG G L V + GP    E V  +   +  +  +Y     G + 
Sbjct: 465  KGVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYS 524

Query: 709  IMVRWGDKDIPGSPFMVHV 765
            I + WG   IP SPF V V
Sbjct: 525  IAITWGGHHIPKSPFEVQV 543

 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 67/261 (25%), Positives = 101/261 (38%), Gaps = 6/261 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P + G + V +   +  I GSPF+  +     DP  V A+G GL    V + 
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADI-EMPFDPSKVVASGPGLEHGKVGEA 1151

Query: 181  AHFFVNTTNAGSGSLNVAI--DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGN 351
                VN + AG G+L +    D  +K  ++    ++G Y  TYV    G Y + + YGG 
Sbjct: 1152 GLLSVNCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGG- 1210

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
                                E+  H    ++       S+          KV   G+  K
Sbjct: 1211 --------------------ELVPHFPARVKVEPAVDTSRI---------KVFGPGIEGK 1241

Query: 532  QARLNSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
                 +   F VD+   +Q G   +   IA P     E  V    +  + V+Y   E G 
Sbjct: 1242 DVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGL 1301

Query: 703  HIIMVRWGDKDIPGSPFMVHV 765
            H++ V + D  IP SPF V V
Sbjct: 1302 HVVEVTYDDVPIPNSPFKVAV 1322

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 76/273 (27%), Positives = 120/273 (43%), Gaps = 17/273 (6%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPV----GHYNADPGMVHATGEGLSRA- 165
            G   VK+ P+E G + V +  + + I  SP+   +    G YN  P +V A G GL ++ 
Sbjct: 602  GSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYN--PDLVRAYGPGLEKSG 659

Query: 166  -VVDKKAHFFVNTTNAGSGSLNV-AIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIIN 333
             +V+  A F V+  +AG   L + A DG   ++++      +G Y  +Y       + I 
Sbjct: 660  CIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIA 719

Query: 334  ITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVIC 513
            + +GG  +I  SP+                  +V I                S+ +KV  
Sbjct: 720  VVWGG-VNIPHSPY------------------RVNIGQG-------------SHPQKVKV 747

Query: 514  QGLGLKQARL--NSVNSFFVDASQAGYGILLVGIAGPVRPCEE------VVVRHVGNNQF 669
             G G++++ L  N    F VD ++AG G + VGI    R   E        + H  N+ F
Sbjct: 748  FGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTF 807

Query: 670  TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
            TV YV   +G + I V +  ++IP SPF V VD
Sbjct: 808  TVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 72/258 (27%), Positives = 104/258 (40%), Gaps = 5/258 (1%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
            Y   + P + G H+V +      I  SPF + VG    +P    A+G GL    V   + 
Sbjct: 414  YRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEA-CNPNACRASGRGLQPKGVRIRET 472

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE--EG-YEFTYVATAPGNYIINITYGGN 351
              F V+T  AGSG L V + GP  +     + +  +G Y F Y  + PG Y I IT+GG+
Sbjct: 473  TDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGH 532

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             HI  SPF                  QV  EA                 +KV   G GL 
Sbjct: 533  -HIPKSPFEV----------------QVGPEAG---------------MQKVRAWGPGLH 560

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
               +     F V++  +  G L   I GP +   ++      +    V Y  KE G + +
Sbjct: 561  GGIVGRSADFVVESIGSEVGSLGFAIEGPSQ--AKIEYNDQNDGSCDVKYWPKEPGEYAV 618

Query: 712  MVRWGDKDIPGSPFMVHV 765
             +   D+DI  SP+M  +
Sbjct: 619  HIMCDDEDIKDSPYMAFI 636

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 67/274 (24%), Positives = 115/274 (41%), Gaps = 7/274 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G  GV +  +E G + V ++ N + I  SP+ +PV   + D   +       S   V++ 
Sbjct: 2246 GSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQP 2305

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
            A F +   N   G ++  +  PS     CH +E   + Y   ++    G + I++ + G+
Sbjct: 2306 ASFAIR-LNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGS 2364

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             H+VGSPF       + G+           +A +   VS Y              G GL+
Sbjct: 2365 -HVVGSPFK-----VRVGEPG---------QAGNPALVSAY--------------GTGLE 2395

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
                   + FF++ ++AG G L V I GP +    C+E          + V Y     G 
Sbjct: 2396 GGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQET------PEGYKVMYTPMAPGN 2449

Query: 703  HIIMVRWGDKD-IPGSPFMVHVD*EIIILTACSN 801
            ++I V++G  + I GSPF   V  + ++    +N
Sbjct: 2450 YLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSAN 2483

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 72/262 (27%), Positives = 108/262 (41%), Gaps = 11/262 (4%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
            + VK+ P  +G + + V    + I  SPFR+ V   + D   V A G GLS+A V+  K 
Sbjct: 807  FTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVDPSH-DASKVKAEGPGLSKAGVENGKP 865

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVN-MNCHETEEGYEFT----YVATAPGNYIINITYG 345
             HF V T  AG   LNV  + P   + +   +  + Y+++    Y  T  GN  + +TYG
Sbjct: 866  THFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYG 925

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G+  I  SPFT        G       S++++   + R                      
Sbjct: 926  GD-PIPKSPFT-------VGVAAPLDLSKIKLNGLENR---------------------- 955

Query: 526  LKQARLNSVNSFFVDASQA-GYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKE 693
                 +     F VD   A G G L V I  P R   PC  +V    G    T  ++ +E
Sbjct: 956  ---VEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPC--LVTPVTGRENSTAKFIpre 1010

Query: 694  SGTHIIMVRWGDKDIPGSPFMV 759
             G + + V +    +PGSP+ V
Sbjct: 1011 EGLYAVDVTYDGHPVPGSPYTV 1032

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 56/261 (21%), Positives = 99/261 (37%), Gaps = 3/261 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P   G + + V+ N K I GSPF   +                 S+  +   
Sbjct: 1874 GTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITD----------DSRRCSQVKLGSA 1923

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNC---HETEEGYEFTYVATAPGNYIINITYGGN 351
            A F ++ +     SL  +I  PS  +  C            +++    G ++++I   GN
Sbjct: 1924 ADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSIKKNGN 1983

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             H+  SP + +   ++ GD                             A +    G GL 
Sbjct: 1984 -HVANSPVSIMVVQSEIGD-----------------------------ARRAKVYGRGLS 2013

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
            + R   ++ F VD   AGYG + + + GP +   ++    + +    V Y     G +I+
Sbjct: 2014 EGRTFEMSDFIVDTRDAGYGGISLAVEGPSKV--DIQTEDLEDGTCKVSYFPTVPGVYIV 2071

Query: 712  MVRWGDKDIPGSPFMVHVD*E 774
              ++ D+ +PGSPF V +  E
Sbjct: 2072 STKFADEHVPGSPFTVKISGE 2092

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 69/264 (26%), Positives = 107/264 (40%), Gaps = 8/264 (3%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAV-VDK 177
            G Y V + P ++G +M+ V      I  SP+RI       D     ATG G++  V   +
Sbjct: 1574 GTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQ-TGDASKCLATGPGIASTVKTGE 1632

Query: 178  KAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYIINITYGG 348
            +  F V+   AG G +   +  P  ++   +  E E+G Y+  Y A  PG Y+I + +GG
Sbjct: 1633 EVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG 1692

Query: 349  NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
               I  SPFT +       D EV    +  + A    C   +    T  A   +    GL
Sbjct: 1693 -VDIPNSPFTVMAT-----DGEVTAVEEAPVNA----CPPGFRPWVTEEAYVPVSDMNGL 1742

Query: 529  KQARLNSVNSFFVDASQAGYGILLVGIAGPVR-PCEEVVVRHVGNNQ---FTVDYVVKES 696
                 + V  F V   +         I G V  P  +     + +N+    TV Y   E 
Sbjct: 1743 GFKPFDLVIPFAVRKGE---------ITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEV 1793

Query: 697  GTHIIMVRWGDKDIPGSPFMVHVD 768
            G H + +++    IP SP   +V+
Sbjct: 1794 GLHEMHIKYMGSHIPESPLQFYVN 1817

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 61/258 (23%), Positives = 102/258 (39%), Gaps = 3/258 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y  ++ P   G + + +      I  SPF + VG   A    V A G GL   +V + 
Sbjct: 509  GVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVGP-EAGMQKVRAWGPGLHGGIVGRS 567

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
            A F V +  +  GSL  AI+GPS+  +  ++  +G  +  Y    PG Y ++I       
Sbjct: 568  ADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDE-D 626

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            I  SP+ A       G                               + V   G GL+++
Sbjct: 627  IKDSPYMAFIHPATGGYN----------------------------PDLVRAYGPGLEKS 658

Query: 538  R--LNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
               +N++  F VD   AG   L +          ++ +++  +  +   Y   ++  H I
Sbjct: 659  GCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTI 718

Query: 712  MVRWGDKDIPGSPFMVHV 765
             V WG  +IP SP+ V++
Sbjct: 719  AVVWGGVNIPHSPYRVNI 736

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 65/263 (24%), Positives = 104/263 (39%), Gaps = 8/263 (3%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y V + P  +G + + ++   + +   P R+ V     D   +   G G+    V ++
Sbjct: 1188 GTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKV-EPAVDTSRIKVFGPGIEGKDVFRE 1246

Query: 181  A--HFFVNT---TNAGSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNYIINI 336
            A   F V++   T  G   +   I  PS  +  C  T+     Y+  Y     G +++ +
Sbjct: 1247 ATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEV 1306

Query: 337  TYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
            TY  +  I  SPF       K   TE  Q S+V+                         Q
Sbjct: 1307 TYD-DVPIPNSPF-------KVAVTEGCQPSRVQ------------------------AQ 1334

Query: 517  GLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
            G GLK+A  N  N F V    AG G L + + GP     ++  R   +   + +Y+    
Sbjct: 1335 GPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSE--SKINCRDNKDGSCSAEYIPFAP 1392

Query: 697  GTHIIMVRWGDKDIPGSPFMVHV 765
            G + + + +G   IPGSPF V V
Sbjct: 1393 GDYDVNITYGGAHIPGSPFRVPV 1415

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 54/258 (20%), Positives = 90/258 (34%), Gaps = 3/258 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P   G ++V  +   + + GSPF + +         +  T    S A V   
Sbjct: 2055 GTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESITRTSRAPSVATVGSI 2114

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAP---GNYIINITYGGN 351
                +      S  ++  +  PS           G     V   P   G + +++ Y G 
Sbjct: 2115 CDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQ 2174

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             H+ GSPF         G                              A KV   G GL+
Sbjct: 2175 -HVTGSPFQFTVGPLGEGG-----------------------------AHKVRAGGPGLE 2204

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
            +        F +   +AG G L + + GP +   E+      N    V Y+ +E G + +
Sbjct: 2205 RGEAGVPAEFSIWTREAGAGGLSIAVEGPSK--AEITFDDHKNGSCGVSYIAQEPGNYEV 2262

Query: 712  MVRWGDKDIPGSPFMVHV 765
             +++ D+ IP SP++V V
Sbjct: 2263 SIKFNDEHIPESPYLVPV 2280

 Score = 38.5 bits (88), Expect = 0.024
 Identities = 25/72 (34%), Positives = 36/72 (50%), Gaps = 2/72 (2%)
 Frame = +1

Query: 559 FFVDASQAGYGILLVGIAGPVRPCEEVVVRHVG--NNQFTVDYVVKESGTHIIMVRWGDK 732
           F VD   AG G ++V +  P    EE  V      N  ++V+Y+ K +G H + V +  +
Sbjct: 277 FTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQ 336

Query: 733 DIPGSPFMVHVD 768
            I  SPF V VD
Sbjct: 337 HISKSPFEVSVD 348
>sp|Q9MZD2|FLNB_RABIT Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
           (ABP-280-like protein) (C254)
          Length = 294

 Score =  225 bits (573), Expect = 1e-58
 Identities = 117/261 (44%), Positives = 162/261 (62%), Gaps = 7/261 (2%)
 Frame = +1

Query: 4   QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
           +Y V+F P E+G H + V+ N   + GSPF++ VG      +P +V A G GL       
Sbjct: 34  KYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGAGLEGGTTGI 93

Query: 178 KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
           ++ FF+NTT AG G+L+V I+GPSKV M+C ET EGY+  Y   APGNY+I + YGG  H
Sbjct: 94  QSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLIGVKYGGPNH 153

Query: 358 IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEA----SDKRCVSQYAEKTTSYAEKVICQGL 522
           IVGSPF A   G +  G     + S + +E+    S + C S    K +S A KV  +G 
Sbjct: 154 IVGSPFKAKVTGQRLVGPGSTNETSSILVESVTRSSTETCYSAIP-KASSDASKVTSKGA 212

Query: 523 GLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
           GL +A +   +SF VD S+AG  +LL+G+ GP  PCEEV ++HVG+ Q+ V YVVKE G 
Sbjct: 213 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGSQQYNVTYVVKERGE 272

Query: 703 HIIMVRWGDKDIPGSPFMVHV 765
           +++ V+WG++ IPGSPF V V
Sbjct: 273 YVLAVKWGEEHIPGSPFHVTV 293

 Score = 32.7 bits (73), Expect = 1.3
 Identities = 16/53 (30%), Positives = 27/53 (50%)
 Frame = +1

Query: 607 IAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
           +  P    EE  V  +  +++ V ++  E+G H I V++    + GSPF V V
Sbjct: 15  VHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRV 67
>sp|Q80X90|FLNB_MOUSE Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein)
            (ABP-280-like protein)
          Length = 2602

 Score =  215 bits (548), Expect = 1e-55
 Identities = 113/261 (43%), Positives = 158/261 (60%), Gaps = 7/261 (2%)
 Frame = +1

Query: 4    QYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN--ADPGMVHATGEGLSRAVVDK 177
            +Y V+F P E+G H + V+ N   + GSPF++ VG      +P +V A G GL       
Sbjct: 2342 KYAVRFIPHENGIHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGAGLETGTTGI 2401

Query: 178  KAHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGYEFTYVATAPGNYIINITYGGNFH 357
            ++ FF+NTT AG G+L+V I+GPSKV M+C E  EGY+  Y   APGNY+I + YGG  H
Sbjct: 2402 QSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEIPEGYKVMYTPMAPGNYLIGVKYGGPNH 2461

Query: 358  IVGSPFTAVCEGTK-TGDTEVEQHSQVEIEA----SDKRCVSQYAEKTTSYAEKVICQGL 522
            I  SPF A   G +        + S + +E+    S + C S    K++S A KV  +G 
Sbjct: 2462 ISRSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIP-KSSSDASKVTSKGA 2520

Query: 523  GLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGT 702
            GL +A +   +SF VD S+AG  +LL+G+ GP  PCEEV ++HVG  Q+ V YVVKE G 
Sbjct: 2521 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGKQQYNVTYVVKERGD 2580

Query: 703  HIIMVRWGDKDIPGSPFMVHV 765
            +++ V+WG++ IPGSPF V V
Sbjct: 2581 YVLAVKWGEEHIPGSPFHVTV 2601

 Score =  133 bits (334), Expect = 7e-31
 Identities = 92/257 (35%), Positives = 125/257 (48%), Gaps = 2/257 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y V++TP E G H+V V  +  PI  SPF++ V      P  VHA G GL  A  +K 
Sbjct: 1288 GTYQVEYTPFEKGFHVVEVTYDDVPIPNSPFKVAVTE-GCQPSRVHAQGPGLKEAFTNKS 1346

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
              F V T  AG G L + ++GPS+  +NC + ++G     Y+  APG+Y +NITYGG  H
Sbjct: 1347 NVFTVVTRGAGIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGG-VH 1405

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQ- 534
            I GSPF       +    +V   S+V+I                         G GL   
Sbjct: 1406 IPGSPF-------RVPSKDVVDPSKVKI------------------------AGPGLSSC 1434

Query: 535  ARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
             R     SF VD+S+AG   L V + GP    E V V   G+   TV Y   + G +I+ 
Sbjct: 1435 VRACIPQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYIVS 1494

Query: 715  VRWGDKDIPGSPFMVHV 765
            V++ D++IP SPF V V
Sbjct: 1495 VKYADEEIPRSPFKVKV 1511

 Score =  103 bits (257), Expect = 6e-22
 Identities = 71/256 (27%), Positives = 113/256 (44%), Gaps = 1/256 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V++ P E G H + ++     I  SP +  V + N+  G V A G GL   V +K 
Sbjct: 1782 GTVTVRYAPTEVGLHEMHIKYRGSHIPESPLQFYVNYPNS--GSVSAYGPGLVYGVANKT 1839

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEGY-EFTYVATAPGNYIINITYGGNFH 357
            A F + T +AG G L++AI+GPSK  ++C + ++G    TY+ T PG+Y I + Y    H
Sbjct: 1840 ATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDK-H 1898

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            I GSPFTA                  +I   ++RC                       Q 
Sbjct: 1899 IPGSPFTA------------------KITDDNRRC----------------------SQV 1918

Query: 538  RLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMV 717
            +L S   F +D S+     L   I  P    E  +++ + NN   + ++ +E G H++ +
Sbjct: 1919 KLGSAADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSI 1978

Query: 718  RWGDKDIPGSPFMVHV 765
            +     +  SP  + V
Sbjct: 1979 KKNGNHVANSPVSIMV 1994

 Score =  100 bits (250), Expect = 4e-21
 Identities = 71/252 (28%), Positives = 112/252 (44%), Gaps = 1/252 (0%)
 Frame = +1

Query: 16   KFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKKAHFFV 195
            KF pre G   V V  +  P+ GSP+ +       DP  V A G GL   +V K A F +
Sbjct: 1005 KFIpreEGLFAVDVTYDGHPVPGSPYTVEAS-LPPDPTKVKAHGPGLEGGLVGKPAEFTI 1063

Query: 196  NTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVGSP 372
            +T  AG+G L + ++GP +  + C +  +G    +Y+ T PG Y +NI +    HI GSP
Sbjct: 1064 DTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILF-EEVHIPGSP 1122

Query: 373  FTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLNSV 552
            F A  E              +  + S                 KV+  G GL+  ++   
Sbjct: 1123 FKADIE--------------MPFDPS-----------------KVVASGPGLEHGKVGEP 1151

Query: 553  NSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWGDK 732
                VD S+AG G L +          EV +++  +  + V YV   +G + + +++G +
Sbjct: 1152 GILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGE 1211

Query: 733  DIPGSPFMVHVD 768
             +P  P  V V+
Sbjct: 1212 LVPHFPAWVKVE 1223

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 68/254 (26%), Positives = 111/254 (43%), Gaps = 2/254 (0%)
 Frame = +1

Query: 10   GVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYN-ADPGMVHATGEGLSRAVVDKKAH 186
            G+ F pre G H+V ++ N   +  SP  I V      D       G+GLS     + + 
Sbjct: 1963 GISFIpreVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGQGLSEGRTFEMSD 2022

Query: 187  FFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIV 363
            F V+T +AG G +++A++GPSKV++   + E+G  + +Y  T PG YI++  +    H+ 
Sbjct: 2023 FIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADE-HVP 2081

Query: 364  GSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARL 543
            GSPFT    G                E   +  +++ +          IC  L LK   +
Sbjct: 2082 GSPFTVKISG----------------EGRVRESITRTSRAPAVATVGSICD-LNLKIPEI 2124

Query: 544  NSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRW 723
            NS +             +   +  P     E  +  +G N   V +V +E G H + V++
Sbjct: 2125 NSSD-------------MSAHVTSPSGHVTEAEIVPMGKNSHCVRFVPQEMGVHTVSVKY 2171

Query: 724  GDKDIPGSPFMVHV 765
              + + GSPF   V
Sbjct: 2172 RGQHVTGSPFQFTV 2185

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 73/253 (28%), Positives = 113/253 (44%), Gaps = 2/253 (0%)
 Frame = +1

Query: 13   VKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPG-MVHATGEGLSRAVVDKKAHF 189
            V+F P+E G H V V+   + + GSPF+  VG         V A G GL R      A F
Sbjct: 2155 VRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGIPAEF 2214

Query: 190  FVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFHIVG 366
             + T  AG+G L++A++GPSK  +   + + G    +Y+A  PGNY ++I +    HI  
Sbjct: 2215 SIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE-HIPD 2273

Query: 367  SPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQARLN 546
            SP+                   V   + D RC++  +            Q  GLK   +N
Sbjct: 2274 SPYLV----------------PVIAPSDDARCLTVLS-----------LQESGLK---VN 2303

Query: 547  SVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIMVRWG 726
               SF +  + A  G +   +  P    EE  V  +  +++ V ++  E+G H I V++ 
Sbjct: 2304 QPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFN 2362

Query: 727  DKDIPGSPFMVHV 765
               + GSPF V V
Sbjct: 2363 GSHVVGSPFKVRV 2375

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 76/261 (29%), Positives = 112/261 (42%), Gaps = 8/261 (3%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G + V +TP + G ++V V+   + I  SPF++ V     D   V A+G GLS   V   
Sbjct: 1477 GTHTVTYTPSQEGPYIVSVKYADEEIPRSPFKVKVLP-TYDASKVTASGPGLSAYGVPAS 1535

Query: 181  --AHFFVNTTNAGSGSLNVAIDG----PSKVNMNCHETEEG-YEFTYVATAPGNYIINIT 339
                F ++  +AG G L V I      P +  +  H+ ++G Y  TY+    G Y+I +T
Sbjct: 1536 LPVEFAIDARDAGEGLLAVQITDQEGKPQRATV--HDNKDGTYAVTYIPDKTGRYMIGVT 1593

Query: 340  YGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQG 519
            YGG+ +I  SP+      T+TGD                             A K +  G
Sbjct: 1594 YGGD-NIPLSPYR--IRATQTGD-----------------------------ASKCLATG 1621

Query: 520  LGL-KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
             G+    +      F VDA  AG G +   I  P     E  V    +  + + Y   + 
Sbjct: 1622 PGIAPTVKTGEEVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENEDGTYDIFYTAAKP 1681

Query: 697  GTHIIMVRWGDKDIPGSPFMV 759
            GT++I VR+G  DIP SPF V
Sbjct: 1682 GTYVIYVRFGGVDIPNSPFTV 1702

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 67/259 (25%), Positives = 103/259 (39%), Gaps = 6/259 (2%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRA--VVDKK 180
            Y V++ P+ +G H V V    + I+ SPF + V     D   V A G GL     + +K 
Sbjct: 315  YSVEYLPKVTGLHKVIVLFAGQHISKSPFEVNVDKAQGDASKVTAKGPGLETTGNIANKP 374

Query: 181  AHFFVNTTNAGSGSLNVAIDGP-SKVNMNCHETEEG---YEFTYVATAPGNYIINITYGG 348
             +F + T  AG G + + ++ P  K ++     + G   Y   Y    PG +++ +++ G
Sbjct: 375  TYFDIYTAGAGVGDIGIEVEDPQGKNSVELLVEDRGNQVYRCVYKPVQPGPHVVKVSFAG 434

Query: 349  NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
            +  I  SPF                               Q  E     A +   +GL  
Sbjct: 435  D-AIPKSPFGV-----------------------------QIGEACNPNACRASGRGLQP 464

Query: 529  KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHI 708
            K  R+     F VD   AG G L V + GP    E V  +   +  ++ +Y     G + 
Sbjct: 465  KGVRIRETADFKVDTKAAGSGELGVTVKGPGGLEELVKQKGFLDGVYSFEYYPSTPGKYS 524

Query: 709  IMVRWGDKDIPGSPFMVHV 765
            + V WG   IP SPF V V
Sbjct: 525  VAVTWGGHHIPKSPFEVQV 543

 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 78/273 (28%), Positives = 121/273 (44%), Gaps = 17/273 (6%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPV----GHYNADPGMVHATGEGLSRA- 165
            G   VK+ P+E G + V +  + + I  SP+   +    G YN  P +V A G GL ++ 
Sbjct: 602  GSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGDYN--PDLVQAYGPGLEKSG 659

Query: 166  -VVDKKAHFFVNTTNAGSGSLNV-AIDGPSK-VNMNCHETEEG-YEFTYVATAPGNYIIN 333
              ++  A F V+  +AGS  L + A DG  + +++      +G Y  +Y       + I 
Sbjct: 660  CTINNPAEFIVDPKDAGSAPLKILAQDGEGQPIDIQMKSRMDGTYACSYTPLKAIKHTIA 719

Query: 334  ITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVIC 513
            + +GG  +I  SP+                  +V I                S+ +KV  
Sbjct: 720  VVWGG-VNIPHSPY------------------RVNIGQG-------------SHPQKVKV 747

Query: 514  QGLGLKQARL--NSVNSFFVDASQAGYGILLVGIAGPVRPC---EEVV---VRHVGNNQF 669
             G G++++ L  N    F VD ++AG G + VGI    R     EE V   + H  N+ F
Sbjct: 748  FGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTF 807

Query: 670  TVDYVVKESGTHIIMVRWGDKDIPGSPFMVHVD 768
            TV YV    G + I V +  ++IP SPF V VD
Sbjct: 808  TVKYVPPAPGRYTIKVLFASQEIPASPFRVKVD 840

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 72/258 (27%), Positives = 105/258 (40%), Gaps = 5/258 (1%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
            Y   + P + G H+V V      I  SPF + +G    +P    A+G GL    V   + 
Sbjct: 414  YRCVYKPVQPGPHVVKVSFAGDAIPKSPFGVQIGEA-CNPNACRASGRGLQPKGVRIRET 472

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHE---TEEGYEFTYVATAPGNYIINITYGGN 351
            A F V+T  AGSG L V + GP  +     +    +  Y F Y  + PG Y + +T+GG+
Sbjct: 473  ADFKVDTKAAGSGELGVTVKGPGGLEELVKQKGFLDGVYSFEYYPSTPGKYSVAVTWGGH 532

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             HI  SPF                  QV  EA                 +KV   G GL 
Sbjct: 533  -HIPKSPFEV----------------QVGPEAG---------------MQKVRAWGPGLH 560

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
               +     F V++  +  G L   I GP +   E   ++ G+    V Y  KE G + +
Sbjct: 561  GGIVGRSADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGS--CDVKYWPKEPGEYAV 618

Query: 712  MVRWGDKDIPGSPFMVHV 765
             +   D+DI  SP+M  +
Sbjct: 619  HIMCDDEDIKDSPYMAFI 636

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 71/271 (26%), Positives = 111/271 (40%), Gaps = 16/271 (5%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVV--D 174
            G Y   +TP ++  H + V      I  SP+R+ +G   + P  V   G G+ R+ +  +
Sbjct: 702  GTYACSYTPLKAIKHTIAVVWGGVNIPHSPYRVNIGQ-GSHPQKVKVFGPGVERSGLKAN 760

Query: 175  KKAHFFVNTTNAGSGSLNVAIDGPSKVNMN---------CHETEEGYEFTYVATAPGNYI 327
            +  HF V+ T AG G ++V I   ++V  +          H   + +   YV  APG Y 
Sbjct: 761  EPTHFTVDCTEAGEGDVSVGIKCDARVLSDDEEDVDFDIIHNANDTFTVKYVPPAPGRYT 820

Query: 328  INITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKV 507
            I + +     I  SPF                  +V+++ S               A KV
Sbjct: 821  IKVLFASQ-EIPASPF------------------RVKVDPSHD-------------ASKV 848

Query: 508  ICQGLGLKQARLNS--VNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNN---QFT 672
              +G GL +A + +     F V    AG   L+V  + P+ P E V    + +N     T
Sbjct: 849  KAEGPGLSKAGVENGKPTHFTVHTKGAGKAPLIVQFSSPL-PGEAVKDLDIIDNYDYSHT 907

Query: 673  VDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
            V Y   + G   ++V +G   IP SPF V V
Sbjct: 908  VKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 67/274 (24%), Positives = 115/274 (41%), Gaps = 7/274 (2%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G  GV +  +E G + V ++ N + I  SP+ +PV   + D   +       S   V++ 
Sbjct: 2246 GSCGVSYIAQEPGNYEVSIKFNDEHIPDSPYLVPVIAPSDDARCLTVLSLQESGLKVNQP 2305

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETE---EGYEFTYVATAPGNYIINITYGGN 351
            A F +   N   G ++  +  PS     CH +E   + Y   ++    G + I++ + G+
Sbjct: 2306 ASFAIR-LNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGIHTIDVKFNGS 2364

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             H+VGSPF       + G+           +A +   VS Y              G GL+
Sbjct: 2365 -HVVGSPFK-----VRVGEPG---------QAGNPALVSAY--------------GAGLE 2395

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKESGT 702
                   + FF++ +QAG G L V I GP +    C+E+         + V Y     G 
Sbjct: 2396 TGTTGIQSEFFINTTQAGPGTLSVTIEGPSKVKMDCQEI------PEGYKVMYTPMAPGN 2449

Query: 703  HIIMVRWGDKD-IPGSPFMVHVD*EIIILTACSN 801
            ++I V++G  + I  SPF   V  + ++    +N
Sbjct: 2450 YLIGVKYGGPNHISRSPFKAKVTGQRLVSPGSAN 2483

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 65/263 (24%), Positives = 103/263 (39%), Gaps = 8/263 (3%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P + G + V +   +  I GSPF+  +     DP  V A+G GL    V + 
Sbjct: 1093 GTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADI-EMPFDPSKVVASGPGLEHGKVGEP 1151

Query: 181  AHFFVNTTNAGSGSLNVAI--DGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGN 351
                V+ + AG G+L +    D  +K  ++    ++G Y  TYV    G Y + + YGG 
Sbjct: 1152 GILCVDCSEAGPGTLGLEAVSDSGAKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGG- 1210

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQH--SQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
                                E+  H  + V++E +             +   K    G+ 
Sbjct: 1211 --------------------ELVPHFPAWVKVEPA-----------IDTSGIKAFGPGIE 1239

Query: 526  LKQARLNSVNSFFVDA---SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKES 696
             K     +   F VD+   +Q G   +   I  P     E  V+   +  + V+Y   E 
Sbjct: 1240 GKDVFREATTDFTVDSRPLTQVGGDHIKAQITNPSGASTECFVKDNADGTYQVEYTPFEK 1299

Query: 697  GTHIIMVRWGDKDIPGSPFMVHV 765
            G H++ V + D  IP SPF V V
Sbjct: 1300 GFHVVEVTYDDVPIPNSPFKVAV 1322

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 56/261 (21%), Positives = 100/261 (38%), Gaps = 3/261 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G   V + P   G + + V+ N K I GSPF   +   N             S+  +   
Sbjct: 1874 GTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDN----------RRCSQVKLGSA 1923

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNC---HETEEGYEFTYVATAPGNYIINITYGGN 351
            A F ++ +     +L  +I  PS  +  C            +++    G ++++I   GN
Sbjct: 1924 ADFLLDISETDLSTLTASIKAPSGRDEPCLLKRLPNNHIGISFIpreVGEHLVSIKKNGN 1983

Query: 352  FHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLK 531
             H+  SP + +   ++ GD                             A +    G GL 
Sbjct: 1984 -HVANSPVSIMVVQSEIGD-----------------------------ARRAKVYGQGLS 2013

Query: 532  QARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHII 711
            + R   ++ F VD   AGYG + + + GP +   ++    + +    V Y     G +I+
Sbjct: 2014 EGRTFEMSDFIVDTRDAGYGGISLAVEGPSKV--DIQTEDLEDGTCKVSYFPTVPGVYIV 2071

Query: 712  MVRWGDKDIPGSPFMVHVD*E 774
              ++ D+ +PGSPF V +  E
Sbjct: 2072 STKFADEHVPGSPFTVKISGE 2092

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 70/260 (26%), Positives = 106/260 (40%), Gaps = 4/260 (1%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAV-VDK 177
            G Y V + P ++G +M+ V      I  SP+RI       D     ATG G++  V   +
Sbjct: 1574 GTYAVTYIPDKTGRYMIGVTYGGDNIPLSPYRIRATQ-TGDASKCLATGPGIAPTVKTGE 1632

Query: 178  KAHFFVNTTNAGSGSLNVAIDGP--SKVNMNCHETEEG-YEFTYVATAPGNYIINITYGG 348
            +  F V+   AG G +   I  P  ++   +  E E+G Y+  Y A  PG Y+I + +GG
Sbjct: 1633 EVGFVVDAKTAGKGKVTCVILTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGG 1692

Query: 349  NFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGL 528
               I  SPFT +       D EV    +  + A    C   +    T  A   +    GL
Sbjct: 1693 -VDIPNSPFTVMAT-----DGEVTAMEEAPVNA----CPPGFRPWVTEEAYVPVSDMNGL 1742

Query: 529  KQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHI 708
                 + V  F   A + G     V +    +   E+V    G    TV Y   E G H 
Sbjct: 1743 GFKPFDLVIPF---AVRKGEITGTVHMPSGKKATPEIVDNKDGT--VTVRYAPTEVGLHE 1797

Query: 709  IMVRWGDKDIPGSPFMVHVD 768
            + +++    IP SP   +V+
Sbjct: 1798 MHIKYRGSHIPESPLQFYVN 1817

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 66/257 (25%), Positives = 102/257 (39%), Gaps = 2/257 (0%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y  ++ P   G + V V      I  SPF + VG   A    V A G GL   +V + 
Sbjct: 509  GVYSFEYYPSTPGKYSVAVTWGGHHIPKSPFEVQVGP-EAGMQKVRAWGPGLHGGIVGRS 567

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINITYGGNFH 357
            A F V +  +  G+L  AI+GPS+  +   +  +G  +  Y    PG Y ++I       
Sbjct: 568  ADFVVESIGSEVGTLGFAIEGPSQAKIEYDDQNDGSCDVKYWPKEPGEYAVHIMCDDE-D 626

Query: 358  IVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLGLKQA 537
            I  SP+ A      TGD   +              V  Y              GL     
Sbjct: 627  IKDSPYMAFIH-PATGDYNPD-------------LVQAYG------------PGLEKSGC 660

Query: 538  RLNSVNSFFVDASQAGYGIL-LVGIAGPVRPCEEVVVRHVGNNQFTVDYVVKESGTHIIM 714
             +N+   F VD   AG   L ++   G  +P  ++ ++   +  +   Y   ++  H I 
Sbjct: 661  TINNPAEFIVDPKDAGSAPLKILAQDGEGQPI-DIQMKSRMDGTYACSYTPLKAIKHTIA 719

Query: 715  VRWGDKDIPGSPFMVHV 765
            V WG  +IP SP+ V++
Sbjct: 720  VVWGGVNIPHSPYRVNI 736

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 71/262 (27%), Positives = 105/262 (40%), Gaps = 11/262 (4%)
 Frame = +1

Query: 7    YGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVD--KK 180
            + VK+ P   G + + V    + I  SPFR+ V   + D   V A G GLS+A V+  K 
Sbjct: 807  FTVKYVPPAPGRYTIKVLFASQEIPASPFRVKVDP-SHDASKVKAEGPGLSKAGVENGKP 865

Query: 181  AHFFVNTTNAGSGSLNVAIDGPSKVN-MNCHETEEGYEFT----YVATAPGNYIINITYG 345
             HF V+T  AG   L V    P     +   +  + Y+++    Y  T  GN  + +TYG
Sbjct: 866  THFTVHTKGAGKAPLIVQFSSPLPGEAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYG 925

Query: 346  GNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQGLG 525
            G+  I  SPFT        G       S+++I   + R                      
Sbjct: 926  GD-PIPKSPFT-------VGVAAPLDLSKIKINGLENR---------------------- 955

Query: 526  LKQARLNSVNSFFVDASQA-GYGILLVGIAGPVR---PCEEVVVRHVGNNQFTVDYVVKE 693
                 +     F +D + A G G L V I  P R   PC  +V    G    T  ++ +E
Sbjct: 956  ---VEVGKDQEFAIDTNGAGGQGKLDVTILSPSRKVVPC--LVAPVAGRECSTAKFIpre 1010

Query: 694  SGTHIIMVRWGDKDIPGSPFMV 759
             G   + V +    +PGSP+ V
Sbjct: 1011 EGLFAVDVTYDGHPVPGSPYTV 1032

 Score = 39.7 bits (91), Expect = 0.011
 Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
 Frame = +1

Query: 559 FFVDASQAGYGILLVGIAGPVRPCEEVVVRHVG--NNQFTVDYVVKESGTHIIMVRWGDK 732
           F VD   AG G ++V +  P    EE  V      N  ++V+Y+ K +G H ++V +  +
Sbjct: 277 FTVDTISAGQGDVMVFVEDPEGNKEEARVTPDSDKNKTYSVEYLPKVTGLHKVIVLFAGQ 336

Query: 733 DIPGSPFMVHVD 768
            I  SPF V+VD
Sbjct: 337 HISKSPFEVNVD 348
>sp|P13466|GELA_DICDI Gelation factor (Actin binding protein 120) (ABP-120)
          Length = 857

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 61/266 (22%), Positives = 106/266 (39%), Gaps = 11/266 (4%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y V++ P + G H V V    +P+   P  + +   N+D    +  G G  +A   + 
Sbjct: 412  GSYDVEYKPTKGGDHTVEVFLRGEPLAQGPTEVKI--LNSDSQNSYCDGPGFEKAQAKRP 469

Query: 181  AHFFVNTTN-------AGSGSLNVAIDGPSKVNMNCHETEEG-YEFTYVATAPGNYIINI 336
              F +++         AG     V+I GP  VN+   + ++G Y   Y    PG+Y I +
Sbjct: 470  TEFTIHSVGADNKPCAAGGDPFQVSISGPHPVNVGITDNDDGTYTVAYTPEQPGDYEIQV 529

Query: 337  TYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVICQ 516
            T                E  K     +               +   A+   SYAE     
Sbjct: 530  TLND-------------EAIKDIPKSIH--------------IKPAADPEKSYAEGPGLD 562

Query: 517  G---LGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFTVDYVV 687
            G       + ++++V+   V  +  G G  +V I GP  P + V+V + G+  + V++  
Sbjct: 563  GGECFQPSKFKIHAVDPDGVHRTDGGDG-FVVTIEGPA-PVDPVMVDN-GDGTYDVEFEP 619

Query: 688  KESGTHIIMVRWGDKDIPGSPFMVHV 765
            KE+G ++I +     ++ G P  V V
Sbjct: 620  KEAGDYVINLTLDGDNVNGFPKTVTV 645

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 66/266 (24%), Positives = 100/266 (37%), Gaps = 15/266 (5%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVH--ATGEGLSRAVVD 174
            G Y V+F P+E+G +++ +  +   +NG P  + V      P   H  A GEGL +   +
Sbjct: 611  GTYDVEFEPKEAGDYVINLTLDGDNVNGFPKTVTV---KPAPSAEHSYAEGEGLVKVFDN 667

Query: 175  KKAHFFVNTTNA-------GSGSLNVAIDGPSKVNMNCHETEEG---YEFTYVATAPGNY 324
              A F +   +        G     VAI+GP  + ++   T+     Y   Y A   GNY
Sbjct: 668  APAEFTIFAVDTKGVARTDGGDPFEVAINGPDGLVVDAKVTDNNDGTYGVVYDAPVEGNY 727

Query: 325  IINITYGGNFHIVGSPFTAVC-EGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAE 501
             +N+T  GN  I   P    C EG    D                   S +   T + A 
Sbjct: 728  NVNVTLRGN-PIKNMPIDVKCIEGANGED-------------------SSFGSFTFTVAA 767

Query: 502  KVICQGLGLKQARLNSVNSFFVDASQAGYGILLVGIAGPVRPCEEVVVRHVGNNQ--FTV 675
            K           +   V ++  D  +       V I G   P EE+ +  + N    +T 
Sbjct: 768  K----------NKKGEVKTYGGDKFE-------VSITG---PAEEITLDAIDNQDGTYTA 807

Query: 676  DYVVKESGTHIIMVRWGDKDIPGSPF 753
             Y +  +G     V+   K I GSPF
Sbjct: 808  AYSLVGNGRFSTGVKLNGKHIEGSPF 833

 Score = 34.3 bits (77), Expect = 0.45
 Identities = 59/271 (21%), Positives = 95/271 (35%), Gaps = 16/271 (5%)
 Frame = +1

Query: 1    GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGHYNADPGMVHATGEGLSRAVVDKK 180
            G Y   +T      + V V+ +      SP+ + +    +D    +A G GL    V   
Sbjct: 312  GIYDASYTATVPQDYTVVVQLDDVHCKDSPYNVKID--GSDAQHSNAYGPGLEGGKVGVP 369

Query: 181  AHFFVN-------TTNAGSGSLNVAIDGPS-KVNMNCHETEEG-YEFTYVATAPGNYIIN 333
            A F +        T   G     V +  P   V+    +  +G Y+  Y  T  G++ + 
Sbjct: 370  AAFKIQGRNKDGETVTQGGDDFTVKVQSPEGPVDAQIKDNGDGSYDVEYKPTKGGDHTVE 429

Query: 334  ITYGGNFHIVGSPFTAVCEGTKTGDTEVEQHSQVEIEASDKRCVSQYAEKTTSYAEKVIC 513
            +   G             E    G TEV+      I  SD +          SY     C
Sbjct: 430  VFLRG-------------EPLAQGPTEVK------ILNSDSQ---------NSY-----C 456

Query: 514  QGLGLKQARLNSVNSFFVDA-------SQAGYGILLVGIAGPVRPCEEVVVRHVGNNQFT 672
             G G ++A+      F + +         AG     V I+GP  P   V +    +  +T
Sbjct: 457  DGPGFEKAQAKRPTEFTIHSVGADNKPCAAGGDPFQVSISGP-HPVN-VGITDNDDGTYT 514

Query: 673  VDYVVKESGTHIIMVRWGDKDIPGSPFMVHV 765
            V Y  ++ G + I V   D+ I   P  +H+
Sbjct: 515  VAYTPEQPGDYEIQVTLNDEAIKDIPKSIHI 545
>sp|Q9R1R2|TRIM3_MOUSE Tripartite motif protein 3 (RING finger protein 22) (RING finger
           protein HAC1)
          Length = 744

 Score = 37.0 bits (84), Expect = 0.069
 Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 10/89 (11%)
 Frame = +1

Query: 139 ATGEGLSRAVVDKKAHFFVNT-------TNAGSGSLNVAIDGPSKVNMNCHETEE---GY 288
           ATGEGL +A+V + A   V T          GS  L   I GP  V +     +     Y
Sbjct: 327 ATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELCAEITGPDGVRLAVPVVDHKNGTY 386

Query: 289 EFTYVATAPGNYIINITYGGNFHIVGSPF 375
           E  Y A   G+ ++++   G   + GSPF
Sbjct: 387 ELVYTARTEGDLLLSVLLYGQ-PVRGSPF 414
>sp|Q6PFY8|TRI45_MOUSE Tripartite motif protein 45
          Length = 580

 Score = 36.6 bits (83), Expect = 0.091
 Identities = 17/47 (36%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
 Frame = +1

Query: 1   GQYGVKFTpreSGTHMVFVENNKKPINGSPFRIPVGH-YNADPGMVH 138
           G Y V +TP+E G + V+V   ++ + GSPF + V   +   PG+ H
Sbjct: 463 GSYRVSYTPKEPGIYTVWVCIREQHVQGSPFNVTVRRKHRPHPGVFH 509
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,576,298
Number of Sequences: 369166
Number of extensions: 2299477
Number of successful extensions: 6138
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5572
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5958
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)