Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02373
(634 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q96L73|NSD1_HUMAN Histone-lysine N-methyltransferase, H3... 87 3e-17
sp|O88491|NSD1_MOUSE Histone-lysine N-methyltransferase, H3... 87 4e-17
sp|Q9NXR8|ING3_HUMAN Inhibitor of growth protein 3 (p47ING3... 46 9e-05
sp|O97159|CHDM_DROME Chromodomain helicase-DNA-binding prot... 45 2e-04
sp|Q8VEK6|ING3_MOUSE Inhibitor of growth protein 3 (p47ING3... 44 3e-04
sp|Q9QXV3|ING1_MOUSE Inhibitor of growth protein 1 44 3e-04
sp|Q9UK53|ING1_HUMAN Inhibitor of growth protein 1 44 3e-04
sp|Q8TDI0|CHD5_HUMAN Chromodomain helicase-DNA-binding prot... 44 4e-04
sp|P38806|YNG2_YEAST ING1 homolog 2 (ESA1-associated factor 4) 43 8e-04
sp|Q22516|CHD3_CAEEL Chromodomain helicase-DNA-binding prot... 42 0.002
>sp|Q96L73|NSD1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20
specific (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear
receptor binding SET domain containing protein 1)
(NR-binding SET domain containing protein) (Androgen
receptor-associated coregulator 267)
Length = 2696
Score = 87.4 bits (215), Expect = 3e-17
Identities = 34/59 (57%), Positives = 37/59 (62%)
Frame = +2
Query: 20 LVLCDKTSCPKTYHLSCLGLEEAPPGTWYCPWHFCDICGKPSKLFCVRCPASFCDTHAE 196
LV C K CPK YH CL L + P G W CPWH CDICGK + FC CP+SFC H E
Sbjct: 2130 LVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHRE 2188
Score = 38.1 bits (87), Expect = 0.019
Identities = 30/87 (34%), Positives = 36/87 (41%), Gaps = 8/87 (9%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCLGLEEAPPGTWYC-----PWHFCDICGKPSKLFCVRCPASFC 181
+L+LC+ C +HL CLGL E P G + C H C +C K S RC C
Sbjct: 1554 ELLLCEAQCCG-AFHLECLGLTEMPRGKFICNECRTGIHTCFVC-KQSGEDVKRCLLPLC 1611
Query: 182 DT--HAEETNIVVPTHETRKSI-CQLH 253
H E PT K C LH
Sbjct: 1612 GKFYHEECVQKYPPTVMQNKGFRCSLH 1638
Score = 36.2 bits (82), Expect = 0.072
Identities = 25/77 (32%), Positives = 35/77 (45%), Gaps = 8/77 (10%)
Frame = +2
Query: 20 LVLCDKTSCPKTYHLSCLGLEEAPPGTWYCPWHFCDICGKP--SKLFCVRC------PAS 175
L+ CD SCP +H CL + + P G WYC + C KP ++ V+ PA
Sbjct: 1719 LLCCD--SCPAAFHRECLNI-DIPEGNWYC--NDCKAGKKPHYREIVWVKVGRYRWWPAE 1773
Query: 176 FCDTHAEETNIVVPTHE 226
C A +NI H+
Sbjct: 1774 ICHPRAVPSNIDKMRHD 1790
>sp|O88491|NSD1_MOUSE Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20
specific (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear
receptor binding SET domain containing protein 1)
(NR-binding SET domain containing protein)
Length = 2588
Score = 87.0 bits (214), Expect = 4e-17
Identities = 33/59 (55%), Positives = 37/59 (62%)
Frame = +2
Query: 20 LVLCDKTSCPKTYHLSCLGLEEAPPGTWYCPWHFCDICGKPSKLFCVRCPASFCDTHAE 196
LV C K CPK YH CL L + P G W CPWH CD+CGK + FC CP+SFC H E
Sbjct: 2028 LVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHRE 2086
Score = 38.1 bits (87), Expect = 0.019
Identities = 30/87 (34%), Positives = 36/87 (41%), Gaps = 8/87 (9%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCLGLEEAPPGTWYC-----PWHFCDICGKPSKLFCVRCPASFC 181
+L+LC+ C +HL CLGL E P G + C H C +C K S RC C
Sbjct: 1452 ELLLCEAQCCG-AFHLECLGLPEMPRGKFICNECHTGIHTCFVC-KQSGEDVKRCLLPLC 1509
Query: 182 DT--HAEETNIVVPTHETRKSI-CQLH 253
H E PT K C LH
Sbjct: 1510 GKFYHEECVQKYPPTVTQNKGFRCPLH 1536
Score = 36.2 bits (82), Expect = 0.072
Identities = 25/77 (32%), Positives = 35/77 (45%), Gaps = 8/77 (10%)
Frame = +2
Query: 20 LVLCDKTSCPKTYHLSCLGLEEAPPGTWYCPWHFCDICGKP--SKLFCVRC------PAS 175
L+ CD SCP +H CL + + P G WYC + C KP ++ V+ PA
Sbjct: 1617 LLCCD--SCPAAFHRECLNI-DIPEGNWYC--NDCKAGKKPHYREIVWVKVGRYRWWPAE 1671
Query: 176 FCDTHAEETNIVVPTHE 226
C A +NI H+
Sbjct: 1672 ICHPRAVPSNIDKMRHD 1688
>sp|Q9NXR8|ING3_HUMAN Inhibitor of growth protein 3 (p47ING3 protein)
Length = 418
Score = 45.8 bits (107), Expect = 9e-05
Identities = 17/38 (44%), Positives = 25/38 (65%), Gaps = 1/38 (2%)
Frame = +2
Query: 2 RIRHEDLVLCDKTSCP-KTYHLSCLGLEEAPPGTWYCP 112
++ + ++V CD CP + +H C+GL EAP G WYCP
Sbjct: 367 QVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCP 404
>sp|O97159|CHDM_DROME Chromodomain helicase-DNA-binding protein Mi-2 homolog (dMi-2)
Length = 1982
Score = 44.7 bits (104), Expect = 2e-04
Identities = 24/74 (32%), Positives = 35/74 (47%), Gaps = 20/74 (27%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCL--GLEEAPPGTWYCP-----------------WHFCDICGK 139
+++LCD +CP+ YHL CL L+E P G W CP FC +C
Sbjct: 388 EIILCD--TCPRAYHLVCLEPELDEPPEGKWSCPHCEADGGAAEEEDDDEHQEFCRVCKD 445
Query: 140 PSKLFCV-RCPASF 178
+L C CP+++
Sbjct: 446 GGELLCCDSCPSAY 459
Score = 38.1 bits (87), Expect = 0.019
Identities = 21/52 (40%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCLG--LEEAPPGTWYCPWHFC-DICGKPSKLFCVR 163
+L+ CD SCP YH CL L+ P G W CP C + GK K+ R
Sbjct: 448 ELLCCD--SCPSAYHTFCLNPPLDTIPDGDWRCPRCSCPPLTGKAEKIITWR 497
>sp|Q8VEK6|ING3_MOUSE Inhibitor of growth protein 3 (p47ING3 protein)
Length = 421
Score = 44.3 bits (103), Expect = 3e-04
Identities = 16/38 (42%), Positives = 25/38 (65%), Gaps = 1/38 (2%)
Frame = +2
Query: 2 RIRHEDLVLCDKTSCP-KTYHLSCLGLEEAPPGTWYCP 112
++ + ++V CD CP + +H C+GL EAP G W+CP
Sbjct: 370 QVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWFCP 407
>sp|Q9QXV3|ING1_MOUSE Inhibitor of growth protein 1
Length = 279
Score = 43.9 bits (102), Expect = 3e-04
Identities = 15/38 (39%), Positives = 24/38 (63%), Gaps = 1/38 (2%)
Frame = +2
Query: 2 RIRHEDLVLCDKTSCP-KTYHLSCLGLEEAPPGTWYCP 112
++ + +++ CD CP + +H SC+GL P G WYCP
Sbjct: 217 QVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCP 254
>sp|Q9UK53|ING1_HUMAN Inhibitor of growth protein 1
Length = 422
Score = 43.9 bits (102), Expect = 3e-04
Identities = 15/38 (39%), Positives = 24/38 (63%), Gaps = 1/38 (2%)
Frame = +2
Query: 2 RIRHEDLVLCDKTSCP-KTYHLSCLGLEEAPPGTWYCP 112
++ + +++ CD CP + +H SC+GL P G WYCP
Sbjct: 360 QVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCP 397
>sp|Q8TDI0|CHD5_HUMAN Chromodomain helicase-DNA-binding protein 5 (CHD-5)
Length = 1954
Score = 43.5 bits (101), Expect = 4e-04
Identities = 27/87 (31%), Positives = 37/87 (42%), Gaps = 33/87 (37%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCLG--LEEAPPGTWYCP--------W----------------- 115
+++LCD +CP+ YHL CL LE+AP G W CP W
Sbjct: 354 EIILCD--TCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEE 411
Query: 116 -----HFCDICGKPSKLFCV-RCPASF 178
FC +C +L C CP+S+
Sbjct: 412 EDDHMEFCRVCKDGGELLCCDACPSSY 438
Score = 38.5 bits (88), Expect = 0.014
Identities = 18/38 (47%), Positives = 22/38 (57%), Gaps = 2/38 (5%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCLG--LEEAPPGTWYCPWHFC 124
+L+ CD +CP +YHL CL L E P G W CP C
Sbjct: 427 ELLCCD--ACPSSYHLHCLNPPLPEIPNGEWLCPRCTC 462
>sp|P38806|YNG2_YEAST ING1 homolog 2 (ESA1-associated factor 4)
Length = 282
Score = 42.7 bits (99), Expect = 8e-04
Identities = 16/38 (42%), Positives = 24/38 (63%), Gaps = 1/38 (2%)
Frame = +2
Query: 2 RIRHEDLVLCDKTSCP-KTYHLSCLGLEEAPPGTWYCP 112
R+ ++V CD +C + +H C+ L+E P GTWYCP
Sbjct: 229 RVSFGEMVACDGPNCKYEWFHYDCVNLKEPPKGTWYCP 266
>sp|Q22516|CHD3_CAEEL Chromodomain helicase-DNA-binding protein 3 homolog (CHD-3)
Length = 1787
Score = 41.6 bits (96), Expect = 0.002
Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 23/77 (29%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCL--GLEEAPPGTWYCP--------------------WHFCDI 130
+L+LCD +C + YH++C+ +E+ P G W CP +C I
Sbjct: 276 ELMLCD--TCTRAYHVACIDENMEQPPEGDWSCPHCEEHGPDVLIVEEEPAKANMDYCRI 333
Query: 131 CGKPSK-LFCVRCPASF 178
C + S L C CP+S+
Sbjct: 334 CKETSNILLCDTCPSSY 350
Score = 35.4 bits (80), Expect = 0.12
Identities = 15/34 (44%), Positives = 21/34 (61%), Gaps = 2/34 (5%)
Frame = +2
Query: 17 DLVLCDKTSCPKTYHLSCLG--LEEAPPGTWYCP 112
+++LCD +CP +YH C+ L E P G W CP
Sbjct: 339 NILLCD--TCPSSYHAYCIDPPLTEIPEGEWSCP 370
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,571,667
Number of Sequences: 369166
Number of extensions: 1367407
Number of successful extensions: 3618
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3450
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3605
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5072399280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)