Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02334
(825 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P79348|RGS20_BOVIN Regulator of G-protein signaling 20 (... 118 2e-26
sp|Q9PWA1|RGS20_CHICK Regulator of G-protein signaling 20 (... 116 9e-26
sp|O76081|RGS20_HUMAN Regulator of G-protein signaling 20 (... 115 1e-25
sp|Q9QZB1|RGS20_MOUSE Regulator of G-protein signaling 20 (... 114 3e-25
sp|Q9PWA0|RGS17_CHICK Regulator of G-protein signaling 17 (... 114 4e-25
sp|Q9QZB0|RGS17_MOUSE Regulator of G-protein signaling 17 (... 112 2e-24
sp|Q9UGC6|RGS17_HUMAN Regulator of G-protein signaling 17 (... 111 2e-24
sp|P49795|RGS19_HUMAN Regulator of G-protein signaling 19 (... 110 6e-24
sp|Q9CX84|RGS19_MOUSE Regulator of G-protein signaling 19 (... 108 2e-23
sp|O70521|RGS19_RAT Regulator of G-protein signaling 19 (RG... 108 2e-23
>sp|P79348|RGS20_BOVIN Regulator of G-protein signaling 20 (RGS20) (Retina-specific
regulator of G-protein signaling) (RET-RGS1)
Length = 374
Score = 118 bits (295), Expect = 2e-26
Identities = 65/136 (47%), Positives = 79/136 (58%)
Frame = +1
Query: 313 NPTSRACYFXXXXXXXXXXLNIKPKLEEPLRTQISNDPQSKLEAISNDEKITLDEAQKWC 492
N S AC F L ++ + E+ LR L TL+EA W
Sbjct: 187 NQGSNACCFCWCCCCSCSCLTVRNQEEQRLRRTSYEARTEDLPTCEESPGPTLEEASAWA 246
Query: 493 HNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAVEELQNETNTDLIEEKARAIYEDYIS 672
+FD LM + AGR F EFL+ E+SEEN++F+ A EEL+ E N IEEKAR IYEDYIS
Sbjct: 247 QSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKATIEEKARIIYEDYIS 306
Query: 673 ILSPKEVSLDSRVRSS 720
ILSPKEVSLDSRVR +
Sbjct: 307 ILSPKEVSLDSRVRET 322
Score = 58.2 bits (139), Expect = 3e-08
Identities = 26/38 (68%), Positives = 31/38 (81%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E IN M EPS + FD+AQLQI+TLM RDSYPRF+NS
Sbjct: 320 RETINRSMAEPSRNIFDDAQLQIYTLMHRDSYPRFMNS 357
>sp|Q9PWA1|RGS20_CHICK Regulator of G-protein signaling 20 (RGS20) (Gz-GAP)
Length = 218
Score = 116 bits (290), Expect = 9e-26
Identities = 69/140 (49%), Positives = 88/140 (62%), Gaps = 3/140 (2%)
Frame = +1
Query: 304 SRNNPTSRACYFXXXXXXXXXXLNIKPKLEEPLRTQISNDPQSKLEAISNDEKI---TLD 474
S N AC F L ++ + EE R + S++ Q+ E I N E+ TL+
Sbjct: 28 SVGNRGPNACCFCWCCCCSCSCLTVRNQEEERAR-RTSHELQA--EGIPNCEESPAPTLE 84
Query: 475 EAQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAVEELQNETNTDLIEEKARAI 654
E W +FD LM + AGR F EFL+ E+SEEN++F+ A EEL+ E+N +IEEKAR I
Sbjct: 85 EVNAWAQSFDKLMLTPAGRNAFREFLRTEFSEENMLFWMACEELKQESNKSVIEEKARLI 144
Query: 655 YEDYISILSPKEVSLDSRVR 714
YEDYISILSPKEVSLDSRVR
Sbjct: 145 YEDYISILSPKEVSLDSRVR 164
Score = 64.7 bits (156), Expect = 3e-10
Identities = 28/38 (73%), Positives = 34/38 (89%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E+IN M+EPS HTFD+AQLQI+TLM RDSYPRF+NS
Sbjct: 164 REVINRNMLEPSQHTFDDAQLQIYTLMHRDSYPRFMNS 201
>sp|O76081|RGS20_HUMAN Regulator of G-protein signaling 20 (RGS20) (Regulator of
Gz-selective protein signaling 1) (Gz-selective
GTPase-activating protein) (G(z)GAP)
Length = 388
Score = 115 bits (289), Expect = 1e-25
Identities = 63/131 (48%), Positives = 82/131 (62%)
Frame = +1
Query: 322 SRACYFXXXXXXXXXXLNIKPKLEEPLRTQISNDPQSKLEAISNDEKITLDEAQKWCHNF 501
S AC F L ++ + E+ T S++ ++ L TL+E W +F
Sbjct: 205 SNACCFCWCCCCSCSCLTVRNQ-EDQRPTIASHELRADLPTWEESPAPTLEEVNAWAQSF 263
Query: 502 DLLMQSSAGRKVFHEFLKLEYSEENIMFYRAVEELQNETNTDLIEEKARAIYEDYISILS 681
D LM + AGR F EFL+ E+SEEN++F+ A EEL+ E N ++IEEKAR IYEDYISILS
Sbjct: 264 DKLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKNIIEEKARIIYEDYISILS 323
Query: 682 PKEVSLDSRVR 714
PKEVSLDSRVR
Sbjct: 324 PKEVSLDSRVR 334
Score = 63.5 bits (153), Expect = 7e-10
Identities = 28/38 (73%), Positives = 33/38 (86%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E+IN MVEPS H FD+AQLQI+TLM RDSYPRF+NS
Sbjct: 334 REVINRNMVEPSQHIFDDAQLQIYTLMHRDSYPRFMNS 371
>sp|Q9QZB1|RGS20_MOUSE Regulator of G-protein signaling 20 (RGS20) (Regulator of G-protein
signaling Z1)
Length = 239
Score = 114 bits (285), Expect = 3e-25
Identities = 63/139 (45%), Positives = 83/139 (59%)
Frame = +1
Query: 298 PISRNNPTSRACYFXXXXXXXXXXLNIKPKLEEPLRTQISNDPQSKLEAISNDEKITLDE 477
P + S AC F L ++ + E+ + S++ ++ + A TL+E
Sbjct: 48 PSQQGGRGSNACCFCWCCCCTCSCLTVRNQ-EDQRPQRASHEIRTDIPACEESPTPTLEE 106
Query: 478 AQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAVEELQNETNTDLIEEKARAIY 657
W +FD LM + AGR F EFL+ E+SEEN++F+ A EEL+ E N IEEKAR IY
Sbjct: 107 VCAWAQSFDNLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKREANKSTIEEKARIIY 166
Query: 658 EDYISILSPKEVSLDSRVR 714
EDYISILSPKEVSLDSRVR
Sbjct: 167 EDYISILSPKEVSLDSRVR 185
Score = 62.4 bits (150), Expect = 1e-09
Identities = 27/38 (71%), Positives = 33/38 (86%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E+IN MV+PS H FD+AQLQI+TLM RDSYPRF+NS
Sbjct: 185 REVINRNMVDPSQHIFDDAQLQIYTLMHRDSYPRFMNS 222
>sp|Q9PWA0|RGS17_CHICK Regulator of G-protein signaling 17 (RGS17)
Length = 210
Score = 114 bits (284), Expect = 4e-25
Identities = 55/93 (59%), Positives = 69/93 (74%)
Frame = +1
Query: 436 LEAISNDEKITLDEAQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAVEELQNE 615
++ I + T DE W NFD +M++ AGR +F EFL+ EYSEEN++F+ A E+L+ E
Sbjct: 64 IQVIEECQNPTADEILSWAQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKE 123
Query: 616 TNTDLIEEKARAIYEDYISILSPKEVSLDSRVR 714
N +IEEKAR IYEDYISILSPKEVSLDSRVR
Sbjct: 124 QNKKVIEEKARLIYEDYISILSPKEVSLDSRVR 156
Score = 56.2 bits (134), Expect = 1e-07
Identities = 23/38 (60%), Positives = 33/38 (86%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E+IN +++PS H +++AQLQI+TLM RDS+PRFLNS
Sbjct: 156 REVINRNLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNS 193
>sp|Q9QZB0|RGS17_MOUSE Regulator of G-protein signaling 17 (RGS17) (Regulator of
Gz-selective protein signaling 2)
Length = 210
Score = 112 bits (279), Expect = 2e-24
Identities = 53/93 (56%), Positives = 68/93 (73%)
Frame = +1
Query: 436 LEAISNDEKITLDEAQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAVEELQNE 615
++ + + T DE W NFD +M++ AGR +F EFL+ EYSEEN++F+ A E+L+ E
Sbjct: 64 IQVLEECQNPTADEVLSWSQNFDKMMKTPAGRNLFREFLRTEYSEENLLFWLACEDLKKE 123
Query: 616 TNTDLIEEKARAIYEDYISILSPKEVSLDSRVR 714
N +EEKAR IYEDYISILSPKEVSLDSRVR
Sbjct: 124 QNKKAVEEKARMIYEDYISILSPKEVSLDSRVR 156
Score = 56.2 bits (134), Expect = 1e-07
Identities = 23/38 (60%), Positives = 33/38 (86%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E+IN +++PS H +++AQLQI+TLM RDS+PRFLNS
Sbjct: 156 REVINRSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNS 193
>sp|Q9UGC6|RGS17_HUMAN Regulator of G-protein signaling 17 (RGS17)
Length = 210
Score = 111 bits (278), Expect = 2e-24
Identities = 53/93 (56%), Positives = 69/93 (74%)
Frame = +1
Query: 436 LEAISNDEKITLDEAQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAVEELQNE 615
++ + + T +E W NFD +M++ AGR +F EFL+ EYSEEN++F+ A E+L+ E
Sbjct: 64 IQVLEECQNPTAEEVLSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDLKKE 123
Query: 616 TNTDLIEEKARAIYEDYISILSPKEVSLDSRVR 714
N +IEEKAR IYEDYISILSPKEVSLDSRVR
Sbjct: 124 QNKKVIEEKARMIYEDYISILSPKEVSLDSRVR 156
Score = 55.1 bits (131), Expect = 2e-07
Identities = 22/38 (57%), Positives = 33/38 (86%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E+IN +++P+ H +++AQLQI+TLM RDS+PRFLNS
Sbjct: 156 REVINRNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNS 193
>sp|P49795|RGS19_HUMAN Regulator of G-protein signaling 19 (RGS19) (G-alpha interacting
protein) (GAIP protein)
Length = 217
Score = 110 bits (274), Expect = 6e-24
Identities = 56/99 (56%), Positives = 71/99 (71%), Gaps = 3/99 (3%)
Frame = +1
Query: 427 QSKLEAISNDEKITL---DEAQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAV 597
+SKL+ + + E +E Q W +FD LM S AGR VF FL+ EYSEEN++F+ A
Sbjct: 64 ESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLAC 123
Query: 598 EELQNETNTDLIEEKARAIYEDYISILSPKEVSLDSRVR 714
EEL+ E N +++EKAR IYEDY+SILSPKEVSLDSRVR
Sbjct: 124 EELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVR 162
Score = 61.6 bits (148), Expect = 2e-09
Identities = 28/38 (73%), Positives = 34/38 (89%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E IN +M EPS+HTFD+AQLQI+TLM RDSYPRFL+S
Sbjct: 162 REGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSS 199
>sp|Q9CX84|RGS19_MOUSE Regulator of G-protein signaling 19 (RGS19)
Length = 216
Score = 108 bits (270), Expect = 2e-23
Identities = 56/99 (56%), Positives = 70/99 (70%), Gaps = 3/99 (3%)
Frame = +1
Query: 427 QSKLEAISNDEKITLD---EAQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAV 597
+SKL+ + + E T E Q W +FD LM S GR VF FL+ EYSEEN++F+ A
Sbjct: 64 ESKLQPLPSCEVCTPPSPKEVQSWAQSFDKLMHSPTGRSVFRAFLRTEYSEENMLFWLAC 123
Query: 598 EELQNETNTDLIEEKARAIYEDYISILSPKEVSLDSRVR 714
EEL+ E N +++EKAR IYEDY+SILSPKEVSLDSRVR
Sbjct: 124 EELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVR 162
Score = 60.1 bits (144), Expect = 7e-09
Identities = 28/38 (73%), Positives = 32/38 (84%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E IN +M EPS HTFD+AQLQI+TLM RDSYPRFL S
Sbjct: 162 REGINRKMQEPSPHTFDDAQLQIYTLMHRDSYPRFLTS 199
>sp|O70521|RGS19_RAT Regulator of G-protein signaling 19 (RGS19) (G-alpha interacting
protein) (GAIP protein)
Length = 216
Score = 108 bits (270), Expect = 2e-23
Identities = 55/99 (55%), Positives = 71/99 (71%), Gaps = 3/99 (3%)
Frame = +1
Query: 427 QSKLEAISNDEKITL---DEAQKWCHNFDLLMQSSAGRKVFHEFLKLEYSEENIMFYRAV 597
+SKL+ + + E T +E Q W +FD LM S GR VF FL+ EYSEEN++F+ A
Sbjct: 64 ESKLQPLPSCEVCTPPSPEEVQSWAQSFDKLMHSPTGRSVFRAFLRTEYSEENMLFWLAC 123
Query: 598 EELQNETNTDLIEEKARAIYEDYISILSPKEVSLDSRVR 714
EEL+ E + +++EKAR IYEDY+SILSPKEVSLDSRVR
Sbjct: 124 EELKTEADRHVVDEKARLIYEDYVSILSPKEVSLDSRVR 162
Score = 60.1 bits (144), Expect = 7e-09
Identities = 28/38 (73%), Positives = 32/38 (84%)
Frame = +3
Query: 711 QELINSQMVEPSSHTFDEAQLQIFTLMQRDSYPRFLNS 824
+E IN +M EPS HTFD+AQLQI+TLM RDSYPRFL S
Sbjct: 162 REGINRKMQEPSPHTFDDAQLQIYTLMHRDSYPRFLTS 199
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.314 0.127 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,589,930
Number of Sequences: 369166
Number of extensions: 1349342
Number of successful extensions: 3832
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3648
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3825
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7956112725
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)