Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02294
(891 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8WWI5|CTL1_HUMAN Choline transporter-like protein 1 (CD... 114 3e-25
sp|Q9I9B9|CTL1_TORMA Choline transporter-like protein 1 114 4e-25
sp|Q6X893|CTL1_MOUSE Choline transporter-like protein 1 (So... 110 4e-24
sp|Q8VII6|CTL1_RAT Choline transporter-like protein 1 (Solu... 110 4e-24
sp|Q8N4M1|CTL3_HUMAN Choline transporter-like protein 3 (So... 87 5e-17
sp|Q921V7|CTL3_MOUSE Choline transporter-like protein 3 (So... 79 1e-14
sp|Q6AY92|CTL3_RAT Choline transporter-like protein 3 (Solu... 77 6e-14
sp|Q810F1|CTL2_CAVPO Choline transporter-like protein 2 (So... 64 4e-10
sp|Q8BY89|CTL2_MOUSE Choline transporter-like protein 2 (So... 62 2e-09
sp|Q8IWA5|CTL2_HUMAN Choline transporter-like protein 2 (So... 58 4e-08
>sp|Q8WWI5|CTL1_HUMAN Choline transporter-like protein 1 (CD92 antigen) (CDw92 antigen)
(Solute carrier family 44 member 1)
Length = 657
Score = 114 bits (286), Expect = 3e-25
Identities = 88/285 (30%), Positives = 132/285 (46%), Gaps = 10/285 (3%)
Frame = +3
Query: 12 LKREEYYQSP-----CPILPVERQIKLLGF--CIRKNISQIMLNSKFNE--IGGINQIKP 164
LK EY SP CP LPV + F C NIS +KF E I ++
Sbjct: 144 LKPSEYTTSPKSSVLCPKLPVPASAPIPFFHRCAPVNIS---CYAKFAEALITFVSDNSV 200
Query: 165 IFESVVRDFILTWKEIMI-LSAGSLVLSFIMVVLIRYLASAXXXXXXXXXXXXXXXXXXF 341
+ + ++T KEI++ L SLVLS I++V+IRY++
Sbjct: 201 LHRLI--SGVMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGV 258
Query: 342 LWLCYCTQENVLSLQFKEKMKYLMGDVFNTRSFLYMAIGSXXXXXXXXXXXXXMWKRILV 521
LW Y Q + + D N R+ L AI + M KR+ +
Sbjct: 259 LWWLYAKQRRSPKETVTPEQLQIAED--NLRALLIYAISATVFTVILFLIMLVMRKRVAL 316
Query: 522 VTHLFREASRCLGQIPCLLFQPIATLLVLAVYFFYWCITFGFLMSVAGYEINNRTGCVKY 701
LF A + +P L+FQP T L +++ YW +T FL G + N G V++
Sbjct: 317 TIALFHVAGKVFIHLPLLVFQPFWTFFALVLFWVYWIMTLLFL-GTTGSPVQNEQGFVEF 375
Query: 702 LTATFPKYVWFYYLVGLVWITEFILAGQQIIIAGTVAQWYFLKNK 836
+ +Y+W+Y++VGL+WI+EFILA QQ+ +AG V +YF ++K
Sbjct: 376 KISGPLQYMWWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK 420
>sp|Q9I9B9|CTL1_TORMA Choline transporter-like protein 1
Length = 646
Score = 114 bits (285), Expect = 4e-25
Identities = 85/270 (31%), Positives = 128/270 (47%), Gaps = 5/270 (1%)
Frame = +3
Query: 42 CPILPVE--RQIKLLGFCIRKNISQIMLNSKFNEIGGINQIKPIFESVVRDFILTWKEIM 215
CPILPV+ + I C+ + S +N F + + + V+ ++T KEI+
Sbjct: 155 CPILPVKSSKPIPFFHRCVPMD-SGCKIN--FKALTTFVSYNSVLQRVITG-VMTSKEII 210
Query: 216 I-LSAGSLVLSFIMVVLIRYLASAXXXXXXXXXXXXXXXXXXFLWLCYCTQENVLSLQFK 392
+ L SLVLS +++V+IRY++ LW Y + L L
Sbjct: 211 VGLCLMSLVLSILLMVIIRYISKVLVWILAILTIIGSIGGTAVLWWLYADHKKTLKLDPS 270
Query: 393 EKMKYLMGDVF--NTRSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREASRCLGQI 566
+ GDV N + L AI + M KR+ + LF A + I
Sbjct: 271 Q------GDVAADNVTALLVCAIIATVITVILLLLMLIMRKRVALTIALFHVAGKVFIHI 324
Query: 567 PCLLFQPIATLLVLAVYFFYWCITFGFLMSVAGYEINNRTGCVKYLTATFPKYVWFYYLV 746
P L+FQ + T L LA ++ YW I L++ AGY G V++ + +Y W Y+LV
Sbjct: 325 PFLIFQSLWTFLALAFFWIYW-IAVLLLLATAGYPQKKDQGYVEFKVSGPLQYTWIYHLV 383
Query: 747 GLVWITEFILAGQQIIIAGTVAQWYFLKNK 836
GL+WI+EFILA QQ+ IAG V +YF ++K
Sbjct: 384 GLIWISEFILACQQMTIAGAVVTYYFTRDK 413
>sp|Q6X893|CTL1_MOUSE Choline transporter-like protein 1 (Solute carrier family 44 member
1)
Length = 653
Score = 110 bits (276), Expect = 4e-24
Identities = 69/216 (31%), Positives = 106/216 (49%), Gaps = 1/216 (0%)
Frame = +3
Query: 192 ILTWKEIMI-LSAGSLVLSFIMVVLIRYLASAXXXXXXXXXXXXXXXXXXFLWLCYCTQE 368
++T KEI++ L SLVLS I++V+IRY++ LW Y Q
Sbjct: 207 VMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTVLVILGSLGGTGVLWWLYAKQR 266
Query: 369 NVLSLQFKEKMKYLMGDVFNTRSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREAS 548
+ + D N R+ L AI + M KR+ + LF A
Sbjct: 267 RSPKEAVIPEQLQIAED--NLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAG 324
Query: 549 RCLGQIPCLLFQPIATLLVLAVYFFYWCITFGFLMSVAGYEINNRTGCVKYLTATFPKYV 728
+ +P L+FQP T L +++ YW +T FL G + N G V+Y + +Y+
Sbjct: 325 KVFIHLPLLVFQPFWTFFALVLFWAYWIMTLLFL-GTTGSAVQNEQGFVEYKISGPLQYM 383
Query: 729 WFYYLVGLVWITEFILAGQQIIIAGTVAQWYFLKNK 836
W+Y++VGL+WI+EFILA QQ+ +AG V +YF ++K
Sbjct: 384 WWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK 419
>sp|Q8VII6|CTL1_RAT Choline transporter-like protein 1 (Solute carrier family 44 member
1)
Length = 656
Score = 110 bits (276), Expect = 4e-24
Identities = 69/216 (31%), Positives = 106/216 (49%), Gaps = 1/216 (0%)
Frame = +3
Query: 192 ILTWKEIMI-LSAGSLVLSFIMVVLIRYLASAXXXXXXXXXXXXXXXXXXFLWLCYCTQE 368
++T KEI++ L SLVLS I++V+IRY++ LW Y Q
Sbjct: 207 VMTSKEIILGLCLLSLVLSMILMVIIRYISRVLVWILTILVILGSLGGTGVLWWLYAKQR 266
Query: 369 NVLSLQFKEKMKYLMGDVFNTRSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREAS 548
+ + D N R+ L AI + M KR+ + LF A
Sbjct: 267 RSPKETVIPEQLQIAED--NLRALLIYAISATVFTVILFLIMLVMRKRVALTIALFHVAG 324
Query: 549 RCLGQIPCLLFQPIATLLVLAVYFFYWCITFGFLMSVAGYEINNRTGCVKYLTATFPKYV 728
+ +P L+FQP T L +++ YW +T FL G + N G V+Y + +Y+
Sbjct: 325 KVFIHLPLLVFQPFWTFFALVLFWAYWIMTLLFL-GTTGSAVQNEQGFVEYKISGPLQYM 383
Query: 729 WFYYLVGLVWITEFILAGQQIIIAGTVAQWYFLKNK 836
W+Y++VGL+WI+EFILA QQ+ +AG V +YF ++K
Sbjct: 384 WWYHVVGLIWISEFILACQQMTVAGAVVTYYFTRDK 419
>sp|Q8N4M1|CTL3_HUMAN Choline transporter-like protein 3 (Solute carrier family 44 member
3)
Length = 653
Score = 87.4 bits (215), Expect = 5e-17
Identities = 77/276 (27%), Positives = 119/276 (43%), Gaps = 9/276 (3%)
Frame = +3
Query: 36 SPCPILPV--ERQIKLLGFCIRKNISQIMLNSKFNEIGGINQIKPIFESVV--RDFILTW 203
S CP LPV + L C+ + L + I ++ + I ++ RD IL
Sbjct: 160 SLCPRLPVPPSKSFPLFNRCVPQTPECYSLFASVL-INDVDTLHRILSGIMSGRDTILG- 217
Query: 204 KEIMILSAGSLVLSFIMVVLIRYLASAXXXXXXXXXXXXXXXXXXFLWLCYCTQENVLSL 383
L +L LS M+ R++ + LW Y N LS+
Sbjct: 218 -----LCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVCGVLWWLYYDYTNDLSI 272
Query: 384 QF---KEKMKYLMGDVFNTRSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREASRC 554
+ +E MK ++G AI S + KRI + LF+ ++
Sbjct: 273 ELDTERENMKCVLG----------FAIVSTGITAVLLVLIFVLRKRIKLTVELFQITNKA 322
Query: 555 LGQIPCLLFQPIATLLVLAVYFFYWCITFGFLMSV--AGYEINNRTGCVKYLTATFPKYV 728
+ P LLFQP+ T +L F+W + L+S+ AG G V+Y + +Y+
Sbjct: 323 ISSAPFLLFQPLWTFAIL---IFFWVLWVAVLLSLGTAGAAQVMEGGQVEYKPLSGIRYM 379
Query: 729 WFYYLVGLVWITEFILAGQQIIIAGTVAQWYFLKNK 836
W Y+L+GL+W +EFILA QQ+ IAG V YF ++K
Sbjct: 380 WSYHLIGLIWTSEFILACQQMTIAGAVVTCYFNRSK 415
>sp|Q921V7|CTL3_MOUSE Choline transporter-like protein 3 (Solute carrier family 44 member
3)
Length = 652
Score = 79.3 bits (194), Expect = 1e-14
Identities = 56/211 (26%), Positives = 92/211 (43%), Gaps = 2/211 (0%)
Frame = +3
Query: 210 IMILSAGSLVLSFIMVVLIRYLASAXXXXXXXXXXXXXXXXXXFLWLCYCTQENVLSLQF 389
I+ L + LS M+ R++++ LW Y N LS +
Sbjct: 214 ILGLCVFTFALSLAMLFAFRFISTLLIHIIISLVILGLLFVCGVLWWLYYDYTNDLSTEL 273
Query: 390 KEKMKYLMGDVFNTRSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREASRCLGQIP 569
+ + N L AI S + KRI + L ++ + P
Sbjct: 274 DTEKE-------NMNCMLAFAIISTVVTVLLLALIFTLRKRIKLTVELLHVTNKAISSCP 326
Query: 570 CLLFQPIATLLVLAVYFFYWCITFGFLMSV--AGYEINNRTGCVKYLTATFPKYVWFYYL 743
LLFQP+ T +L F+W + L+S+ AG G V+Y + +Y+W+Y+L
Sbjct: 327 FLLFQPLWTCAIL---IFFWVLWVAVLLSLGTAGTAQVMEGGQVEYKPLSGIRYMWWYHL 383
Query: 744 VGLVWITEFILAGQQIIIAGTVAQWYFLKNK 836
+GL+W +EFILA Q++ +AG + YF +N+
Sbjct: 384 IGLIWTSEFILACQRMTVAGAMVACYFNRNQ 414
>sp|Q6AY92|CTL3_RAT Choline transporter-like protein 3 (Solute carrier family 44 member
3)
Length = 604
Score = 77.0 bits (188), Expect = 6e-14
Identities = 66/281 (23%), Positives = 116/281 (41%), Gaps = 11/281 (3%)
Frame = +3
Query: 27 YYQSP-----CPILPV--ERQIKLLGFCIRKNIS--QIMLNSKFNEIGGINQIKPIFESV 179
Y QSP CP LPV + L CI + + + N+ +++I
Sbjct: 104 YTQSPSADRLCPRLPVPPSKPFPLFNRCIPQTPECYSLFASVLLNDADALHRI------- 156
Query: 180 VRDFILTWKEIMILSAGSLVLSFIMVVLIRYLASAXXXXXXXXXXXXXXXXXXFLWLCYC 359
+ + I+ L A LS M+ R++++ W Y
Sbjct: 157 LSGIMAGRDTILGLCAFVFALSLAMLFTFRFISTLLVHIIISLVILGLLFVCGVFWWLYY 216
Query: 360 TQENVLSLQFKEKMKYLMGDVFNTRSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFR 539
N LS + + + N + L A+ + + KR+ + L R
Sbjct: 217 DYTNDLSTELDTEKE-------NMKCMLAFAVITTVVTVVLLALIFTLRKRVKLTVELLR 269
Query: 540 EASRCLGQIPCLLFQPIATLLVLAVYFFYWCITFGFLMSV--AGYEINNRTGCVKYLTAT 713
++ + + P LL QP+ T +L F+W + L+S+ AG G V+Y +
Sbjct: 270 VTNKAISRCPFLLLQPLWTFAILV---FFWVLWVAVLLSLGTAGTAQVMEGGQVEYKPLS 326
Query: 714 FPKYVWFYYLVGLVWITEFILAGQQIIIAGTVAQWYFLKNK 836
+Y+W+Y+L+GL+W +EFIL Q++ +AG + YF +N+
Sbjct: 327 GIRYLWWYHLIGLIWTSEFILTCQRMTVAGAMVTCYFNRNQ 367
>sp|Q810F1|CTL2_CAVPO Choline transporter-like protein 2 (Solute carrier family 44 member
2) (Inner ear supporting cell antigen) (IESCA)
Length = 705
Score = 64.3 bits (155), Expect = 4e-10
Identities = 65/289 (22%), Positives = 116/289 (40%), Gaps = 41/289 (14%)
Frame = +3
Query: 93 RKNISQIMLNSKFNEIGGINQIKPIFESVVRDFILTWKEIMILSAGSLVLSFIMVVLIRY 272
RKNI++++ +K + GI + + + + D+ ++W I+I ++VLS + ++L+R+
Sbjct: 197 RKNITELVEGAK--QANGILEARQLAMRIFEDYTVSWYWIVIGLVIAMVLSLLFIILLRF 254
Query: 273 LASAXXXXXXXXXXXXXXXXXXFLWLCYC-------TQENVLSLQFKEKMKYLMGDVFNT 431
LA ++ Y + +VL L F+ + +
Sbjct: 255 LAGIMVWVMIVLVILVLGYGIFHCYMEYARLRGEAGSDISVLDLGFQTDFRVYL---HLR 311
Query: 432 RSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREASRCLGQIPCLLFQPIATLLVLA 611
+++L I + KRIL+ L +EASR +G + C L P+ T +L
Sbjct: 312 QTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLC 371
Query: 612 VYFFYWCITFGFL--MSVAGYEINNRTGCVKYLTATFPKYVW----------------FY 737
+ YW T FL + A Y+I + C P+ + FY
Sbjct: 372 LCIAYWASTAVFLSTSNEAVYKILGDSSCPHQGQTCHPETFFNSTEAHACPNARCQFAFY 431
Query: 738 --------YLVGL--------VWITEFILAGQQIIIAGTVAQWYFLKNK 836
L+GL W+ F+LA Q+ +AG A +Y+ K
Sbjct: 432 GGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRK 480
>sp|Q8BY89|CTL2_MOUSE Choline transporter-like protein 2 (Solute carrier family 44 member
2)
Length = 704
Score = 62.0 bits (149), Expect = 2e-09
Identities = 63/293 (21%), Positives = 117/293 (39%), Gaps = 41/293 (13%)
Frame = +3
Query: 81 GFCIRKNISQIMLNSKFNEIGGINQIKPIFESVVRDFILTWKEIMILSAGSLVLSFIMVV 260
G RKNI+ ++ +K + I + + + + D+ ++W I+I ++VLS + +V
Sbjct: 192 GHGARKNITDLVEGAK--KANKILEARQLAMQIFEDYTVSWYWIIIGLVIAMVLSLLFIV 249
Query: 261 LIRYLASAXXXXXXXXXXXXXXXXXXFLWLCYC-------TQENVLSLQFKEKMKYLMGD 419
L+R+LA ++ Y + +++ L F+ ++ +
Sbjct: 250 LLRFLAGIMVWVMIVMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDLRVYL-- 307
Query: 420 VFNTRSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREASRCLGQIPCLLFQPIATL 599
++++ I + KRIL+ L +EASR +G + C L P+ T
Sbjct: 308 -HLRQTWMAFMIILSILEVVIILLLIFLRKRILIAIALIKEASRAVGHVMCSLLYPLVTF 366
Query: 600 LVLAVYFFYWCITFGFL--MSVAGYEINNRTGCVKYLTA----TFP-------------- 719
+L + YW T FL + A Y++ + T C TFP
Sbjct: 367 FLLCLCIAYWASTSVFLSTSNTAVYKVVDDTACPLLRKTCNPETFPLRNESLQCPTARCQ 426
Query: 720 ------KYVWFYYLVGL--------VWITEFILAGQQIIIAGTVAQWYFLKNK 836
+ + L+GL W+ F+LA Q+ +AG A +Y+ K
Sbjct: 427 FAFYGGESTYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWAMRK 479
>sp|Q8IWA5|CTL2_HUMAN Choline transporter-like protein 2 (Solute carrier family 44 member
2)
Length = 706
Score = 57.8 bits (138), Expect = 4e-08
Identities = 63/291 (21%), Positives = 119/291 (40%), Gaps = 43/291 (14%)
Frame = +3
Query: 93 RKNISQIMLNSKFNEIGGINQIKPIFESVVRDFILTWKEIMILSAGSLVLSFIMVVLIRY 272
RKNI+ ++ +K + G+ + + + + D+ ++W I+I ++ +S + ++L+R+
Sbjct: 198 RKNITDLVEGAK--KANGVLEARQLAMRIFEDYTVSWYWIIIGLVIAMAMSLLFIILLRF 255
Query: 273 LASAXXXXXXXXXXXXXXXXXXFLWLCYC-------TQENVLSLQFKEKMKYLMGDVFNT 431
LA ++ Y + +++ L F+ + +
Sbjct: 256 LAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLGFQTDFRVYL---HLR 312
Query: 432 RSFLYMAIGSXXXXXXXXXXXXXMWKRILVVTHLFREASRCLGQIPCLLFQPIATLLVLA 611
+++L I + KRIL+ L +EASR +G + C L P+ T +L
Sbjct: 313 QTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCSLLYPLVTFFLLC 372
Query: 612 VYFFYWCITFGFL--MSVAGYEINNRTGCVKYLTA------TFP-----------KYVWF 734
+ YW T FL + A Y+I + + C TA TFP + +
Sbjct: 373 LCIAYWASTAVFLSTSNEAVYKIFDDSPCP--FTAKTCNPETFPSSNESRQCPNARCQFA 430
Query: 735 YY---------LVGL--------VWITEFILAGQQIIIAGTVAQWYFLKNK 836
+Y L+GL W+ F+LA Q+ +AG A +Y+ K
Sbjct: 431 FYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALRK 481
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,921,564
Number of Sequences: 369166
Number of extensions: 2026670
Number of successful extensions: 4844
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4667
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4827
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8934348180
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)