Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02260
(795 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y0H4|SUDX_DROME E3 ubiquitin-protein ligase suppressor... 268 2e-71
sp|Q96J02|ITCH_HUMAN Itchy homolog E3 ubiquitin protein lig... 253 4e-67
sp|Q8C863|ITCH_MOUSE Itchy E3 ubiquitin protein ligase 253 4e-67
sp|Q9H0M0|WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase... 252 9e-67
sp|Q9DBH0|WWP2_MOUSE NEDD4-like E3 ubiquitin-protein ligase... 252 9e-67
sp|Q8BZZ3|WWP1_MOUSE NEDD4-like E3 ubiquitin-protein ligase... 252 9e-67
sp|O00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase... 250 3e-66
sp|Q5RBF2|NED4L_PONPY E3 ubiquitin-protein ligase NEDD4-lik... 207 3e-53
sp|Q8CFI0|NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4-lik... 207 3e-53
sp|Q96PU5|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-lik... 207 3e-53
>sp|Q9Y0H4|SUDX_DROME E3 ubiquitin-protein ligase suppressor of deltex
Length = 949
Score = 268 bits (684), Expect = 2e-71
Identities = 119/184 (64%), Positives = 153/184 (83%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
EVLG++ HEL G + +VT+ENK+EYI LM W +T+G+E+Q K FLEG E+VPL
Sbjct: 756 EVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEW 815
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVVWFWKFVRSLDHEQQARLLQ 362
L+ FDERELEL+LCG+Q +DV+DW+R+T+YR Y+ ++ QVVWFW+FVR D+E++ARLLQ
Sbjct: 816 LKYFDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQ 875
Query: 363 FVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVEK 542
FVTGTCR+P+GGF+EL G NG Q FC+E+VG ETWLPRSHTCFNRLDLPPY++YDQ VEK
Sbjct: 876 FVTGTCRVPVGGFAELMGSNGPQRFCIEKVGKETWLPRSHTCFNRLDLPPYKSYDQLVEK 935
Query: 543 LSLA 554
L+ A
Sbjct: 936 LTFA 939
>sp|Q96J02|ITCH_HUMAN Itchy homolog E3 ubiquitin protein ligase (Itch)
(Atrophin-1-interacting protein 4) (AIP4)
(NFE2-associated polypeptide 1) (NAPP1)
Length = 903
Score = 253 bits (646), Expect = 4e-67
Identities = 108/184 (58%), Positives = 149/184 (80%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E+LGE+K H+L P G + VT+ENK+EYI+++ W L++GVE+Q + F EG EI+P
Sbjct: 710 EILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQY 769
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVVWFWKFVRSLDHEQQARLLQ 362
LQ FD +ELE+LLCG+Q+ID++DW+RH +YR Y+ ++ Q++WFW+FV+ +D+E++ RLLQ
Sbjct: 770 LQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQ 829
Query: 363 FVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVEK 542
FVTGTCRLP+GGF++L G NG Q FC+E+VG E WLPRSHTCFNRLDLPPY++Y+Q EK
Sbjct: 830 FVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEK 889
Query: 543 LSLA 554
L A
Sbjct: 890 LLFA 893
>sp|Q8C863|ITCH_MOUSE Itchy E3 ubiquitin protein ligase
Length = 864
Score = 253 bits (646), Expect = 4e-67
Identities = 108/184 (58%), Positives = 149/184 (80%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E+LGE+K H+L P G + VT+ENK+EYI+++ W L++GVE+Q + F EG EI+P
Sbjct: 671 EILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQY 730
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVVWFWKFVRSLDHEQQARLLQ 362
LQ FD +ELE+LLCG+Q+ID++DW+RH +YR Y+ ++ Q++WFW+FV+ +D+E++ RLLQ
Sbjct: 731 LQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIMWFWQFVKEIDNEKRMRLLQ 790
Query: 363 FVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVEK 542
FVTGTCRLP+GGF++L G NG Q FC+E+VG E WLPRSHTCFNRLDLPPY++Y+Q EK
Sbjct: 791 FVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEK 850
Query: 543 LSLA 554
L A
Sbjct: 851 LLFA 854
>sp|Q9H0M0|WWP1_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP1 (WW domain-containing
protein 1) (Atropin-1 interacting protein 5) (AIP5)
Length = 922
Score = 252 bits (643), Expect = 9e-67
Identities = 111/184 (60%), Positives = 148/184 (80%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E+LG+V H+L GG+ + VT+ENK EYI LM W ++GV++Q K FL+G E+VPL
Sbjct: 729 EILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQW 788
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVVWFWKFVRSLDHEQQARLLQ 362
LQ FDE+ELE++LCG+Q++D+ DW+R+TVYR Y+ ++ Q++WFW+FV+ D+E + RLLQ
Sbjct: 789 LQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQ 848
Query: 363 FVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVEK 542
FVTGTCRLPLGGF+EL G NG Q FC+E+VG +TWLPRSHTCFNRLDLPPY++Y+Q EK
Sbjct: 849 FVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEK 908
Query: 543 LSLA 554
L A
Sbjct: 909 LLFA 912
>sp|Q9DBH0|WWP2_MOUSE NEDD4-like E3 ubiquitin-protein ligase WWP2 (WW domain-containing
protein 2)
Length = 870
Score = 252 bits (643), Expect = 9e-67
Identities = 110/184 (59%), Positives = 147/184 (79%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E+LG+V HEL GG ++VT+ENK+EYI L+ W T+GVE+Q K FL+G E+ PL
Sbjct: 677 EILGKVTTHELKEGGENIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEW 736
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVVWFWKFVRSLDHEQQARLLQ 362
L+ FDE+ELEL+LCG+Q+ID+ DW+++ +YR Y+ S+ Q+ WFW+ V+ +D+E++ RLLQ
Sbjct: 737 LRYFDEKELELMLCGMQEIDMSDWQKNAIYRHYTKSSKQIQWFWQVVKEMDNEKRIRLLQ 796
Query: 363 FVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVEK 542
FVTGTCRLP+GGF+EL G NG Q FC++RVG ETWLPRSHTCFNRLDLPPY++Y+Q EK
Sbjct: 797 FVTGTCRLPVGGFAELIGSNGPQKFCIDRVGKETWLPRSHTCFNRLDLPPYKSYEQLKEK 856
Query: 543 LSLA 554
L A
Sbjct: 857 LLYA 860
>sp|Q8BZZ3|WWP1_MOUSE NEDD4-like E3 ubiquitin-protein ligase WWP1 (WW domain-containing
protein 1)
Length = 918
Score = 252 bits (643), Expect = 9e-67
Identities = 111/184 (60%), Positives = 148/184 (80%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E+LG+V H+L GG+ + VT+ENK EYI LM W ++GV++Q K FL+G E+VPL
Sbjct: 725 EILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQW 784
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVVWFWKFVRSLDHEQQARLLQ 362
LQ FDE+ELE++LCG+Q++D+ DW+R+TVYR Y+ ++ Q++WFW+FV+ D+E + RLLQ
Sbjct: 785 LQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQ 844
Query: 363 FVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVEK 542
FVTGTCRLPLGGF+EL G NG Q FC+E+VG +TWLPRSHTCFNRLDLPPY++Y+Q EK
Sbjct: 845 FVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEK 904
Query: 543 LSLA 554
L A
Sbjct: 905 LLFA 908
>sp|O00308|WWP2_HUMAN NEDD4-like E3 ubiquitin-protein ligase WWP2 (WW domain-containing
protein 2) (Atrophin-1-interacting protein 2) (AIP2)
Length = 870
Score = 250 bits (639), Expect = 3e-66
Identities = 109/184 (59%), Positives = 147/184 (79%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E+LG+V HEL GG ++VT+ENK+EYI L+ W T+GVE+Q K FL+G E+ PL
Sbjct: 677 EILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEW 736
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQYSPSNIQVVWFWKFVRSLDHEQQARLLQ 362
L+ FDE+ELEL+LCG+Q+ID+ DW++ T+YR Y+ ++ Q+ WFW+ V+ +D+E++ RLLQ
Sbjct: 737 LRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQ 796
Query: 363 FVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVEK 542
FVTGTCRLP+GGF+EL G NG Q FC+++VG ETWLPRSHTCFNRLDLPPY++Y+Q EK
Sbjct: 797 FVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREK 856
Query: 543 LSLA 554
L A
Sbjct: 857 LLYA 860
>sp|Q5RBF2|NED4L_PONPY E3 ubiquitin-protein ligase NEDD4-like protein
Length = 959
Score = 207 bits (527), Expect = 3e-53
Identities = 97/185 (52%), Positives = 132/185 (71%), Gaps = 1/185 (0%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E G+ +L P G+E+ VT+ENK+EYI L+I W V+KQM FLEG E++P+ L
Sbjct: 764 ENFGQTYQVDLEPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDL 823
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQ-YSPSNIQVVWFWKFVRSLDHEQQARLL 359
++ FDE ELELL+CGL +DV+DW +H++Y+ Y P++ + WFWK V +D E++ RLL
Sbjct: 824 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 883
Query: 360 QFVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVE 539
QFVTGT R+P+ GF+EL G NG QLF +E+ G LPR+HTCFNRLDLPPY T++ E
Sbjct: 884 QFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLRE 943
Query: 540 KLSLA 554
KL +A
Sbjct: 944 KLLMA 948
>sp|Q8CFI0|NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4-like protein (Nedd4-2) (NEDD4.2)
Length = 1004
Score = 207 bits (527), Expect = 3e-53
Identities = 97/185 (52%), Positives = 132/185 (71%), Gaps = 1/185 (0%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E G+ +L P G+E+ VT+ENK+EYI L+I W V+KQM FLEG E++P+ L
Sbjct: 809 ENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDL 868
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQ-YSPSNIQVVWFWKFVRSLDHEQQARLL 359
++ FDE ELELL+CGL +DV+DW +H++Y+ Y P++ + WFWK V +D E++ RLL
Sbjct: 869 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 928
Query: 360 QFVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVE 539
QFVTGT R+P+ GF+EL G NG QLF +E+ G LPR+HTCFNRLDLPPY T++ E
Sbjct: 929 QFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLRE 988
Query: 540 KLSLA 554
KL +A
Sbjct: 989 KLLMA 993
>sp|Q96PU5|NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4-like protein (Nedd4-2) (NEDD4.2)
Length = 975
Score = 207 bits (527), Expect = 3e-53
Identities = 97/185 (52%), Positives = 132/185 (71%), Gaps = 1/185 (0%)
Frame = +3
Query: 3 EVLGEVKLHELIPGGNEVKVTDENKKEYIQLMIPWWLTKGVEKQMKNFLEGLYEIVPLSL 182
E G+ +L P G+E+ VT+ENK+EYI L+I W V+KQM FLEG E++P+ L
Sbjct: 780 ENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDL 839
Query: 183 LQRFDERELELLLCGLQKIDVDDWERHTVYRQ-YSPSNIQVVWFWKFVRSLDHEQQARLL 359
++ FDE ELELL+CGL +DV+DW +H++Y+ Y P++ + WFWK V +D E++ RLL
Sbjct: 840 IKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 899
Query: 360 QFVTGTCRLPLGGFSELQGGNGRQLFCLERVGDETWLPRSHTCFNRLDLPPYRTYDQFVE 539
QFVTGT R+P+ GF+EL G NG QLF +E+ G LPR+HTCFNRLDLPPY T++ E
Sbjct: 900 QFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLRE 959
Query: 540 KLSLA 554
KL +A
Sbjct: 960 KLLMA 964
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,391,480
Number of Sequences: 369166
Number of extensions: 1767308
Number of successful extensions: 4467
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4286
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4417
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7473924075
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)