Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02250
(808 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9XZ58|CSN5_DROME COP9 signalosome complex subunit 5 (Si... 357 2e-98
sp|Q6P635|CSN5_XENTR COP9 signalosome complex subunit 5 (Si... 353 2e-97
sp|Q6GLM9|CSN5_XENLA COP9 signalosome complex subunit 5 (Si... 353 3e-97
sp|Q6PC30|CSN5_BRARE COP9 signalosome complex subunit 5 (Si... 353 4e-97
sp|Q92905|CSN5_HUMAN COP9 signalosome complex subunit 5 (Si... 352 5e-97
sp|O35864|CSN5_MOUSE COP9 signalosome complex subunit 5 (Si... 352 5e-97
sp|Q9FVU9|CSN5A_ARATH COP9 signalosome complex subunit 5a (... 331 1e-90
sp|Q8LAZ7|CSN5B_ARATH COP9 signalosome complex subunit 5b (... 325 7e-89
sp|P91001|CSN5_CAEEL COP9 signalosome complex subunit 5 (Si... 323 3e-88
sp|O94454|CSN5_SCHPO COP9 signalosome complex subunit 5 (CS... 228 1e-59
>sp|Q9XZ58|CSN5_DROME COP9 signalosome complex subunit 5 (Signalosome subunit 5) (Dch5)
(JAB1 homolog)
Length = 327
Score = 357 bits (917), Expect = 2e-98
Identities = 160/236 (67%), Positives = 199/236 (84%), Gaps = 2/236 (0%)
Frame = +1
Query: 55 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHAR 228
++WELENN+ T+ D++FRYD I+ +KPW KD H+FK I++SA ALLKMV HAR
Sbjct: 8 KTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHAR 67
Query: 229 RGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRT 408
GG LEVMG++ GKV NTMIVMD+ ALPVEGTETRVNAQ++AYE++T Y + ++GR
Sbjct: 68 SGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRM 127
Query: 409 ENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYP 588
E+ +GWYHSHPGYGCWLSGIDV+TQ +NQTYQ+PFVA+V+DPVRTVS+GKV +GAFRTYP
Sbjct: 128 EHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYP 187
Query: 589 RNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYW 756
+ Y PP++ PSEYQ+IPLNKIEDFGVHCKQYYPL +SYFKS+LD+ +LD LWN+YW
Sbjct: 188 KGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYW 243
>sp|Q6P635|CSN5_XENTR COP9 signalosome complex subunit 5 (Signalosome subunit 5)
Length = 334
Score = 353 bits (907), Expect = 2e-97
Identities = 159/251 (63%), Positives = 197/251 (78%), Gaps = 2/251 (0%)
Frame = +1
Query: 55 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHAR 228
++WEL NN+ + D++++YD I+ +KPW KD HYFKY +VSA ALLKMV HAR
Sbjct: 11 KTWELSNNMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKVSALALLKMVMHAR 70
Query: 229 RGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRT 408
GGNLEVMG++ GKV TMI+MDS ALPVEGTETRVNAQ+ AYE++ Y + ++GR
Sbjct: 71 SGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRL 130
Query: 409 ENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYP 588
EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP
Sbjct: 131 ENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYP 190
Query: 589 RNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYWXXXX 768
+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW
Sbjct: 191 KGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTL 250
Query: 769 XXXXXXXQPDY 801
DY
Sbjct: 251 SSSSLLTNADY 261
>sp|Q6GLM9|CSN5_XENLA COP9 signalosome complex subunit 5 (Signalosome subunit 5)
Length = 332
Score = 353 bits (906), Expect = 3e-97
Identities = 157/236 (66%), Positives = 195/236 (82%), Gaps = 2/236 (0%)
Frame = +1
Query: 55 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHAR 228
++WEL NN+ + D++++YD I+ +KPW KD HYFKY +VSA ALLKMV HAR
Sbjct: 9 KTWELSNNMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKVSALALLKMVMHAR 68
Query: 229 RGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRT 408
GGNLEVMG++ GKV TMI+MDS ALPVEGTETRVNAQ+ AYE++ Y + ++GR
Sbjct: 69 SGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRL 128
Query: 409 ENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYP 588
EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP
Sbjct: 129 ENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYP 188
Query: 589 RNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYW 756
+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW
Sbjct: 189 KGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYW 244
>sp|Q6PC30|CSN5_BRARE COP9 signalosome complex subunit 5 (Signalosome subunit 5)
Length = 334
Score = 353 bits (905), Expect = 4e-97
Identities = 158/253 (62%), Positives = 199/253 (78%), Gaps = 2/253 (0%)
Frame = +1
Query: 49 SLQSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTH 222
++++WEL N++ + D++++YD I+ +KPW KD HYFKY ++SA ALLKMV H
Sbjct: 7 AMKTWELSNSMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKLSALALLKMVMH 66
Query: 223 ARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIG 402
AR GGNLEVMG++ GKV TMI+MDS ALPVEGTETRVNAQ+ AYE++ Y + ++G
Sbjct: 67 ARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVG 126
Query: 403 RTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRT 582
R EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRT
Sbjct: 127 RLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRT 186
Query: 583 YPRNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYWXX 762
YP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW
Sbjct: 187 YPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVN 246
Query: 763 XXXXXXXXXQPDY 801
DY
Sbjct: 247 TLSSSSLLTNADY 259
>sp|Q92905|CSN5_HUMAN COP9 signalosome complex subunit 5 (Signalosome subunit 5) (SGN5)
(Jun activation domain-binding protein 1)
Length = 334
Score = 352 bits (904), Expect = 5e-97
Identities = 159/251 (63%), Positives = 196/251 (78%), Gaps = 2/251 (0%)
Frame = +1
Query: 55 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHAR 228
++WEL NN+ D++++YD I+ +KPW KD HYFKY ++SA ALLKMV HAR
Sbjct: 11 KTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHAR 70
Query: 229 RGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRT 408
GGNLEVMG++ GKV TMI+MDS ALPVEGTETRVNAQ+ AYE++ Y + ++GR
Sbjct: 71 SGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRL 130
Query: 409 ENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYP 588
EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP
Sbjct: 131 ENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYP 190
Query: 589 RNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYWXXXX 768
+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW
Sbjct: 191 KGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTL 250
Query: 769 XXXXXXXQPDY 801
DY
Sbjct: 251 SSSSLLTNADY 261
>sp|O35864|CSN5_MOUSE COP9 signalosome complex subunit 5 (Signalosome subunit 5) (SGN5)
(Jun activation domain-binding protein 1) (Kip1
C-terminus-interacting protein 2)
Length = 334
Score = 352 bits (904), Expect = 5e-97
Identities = 159/251 (63%), Positives = 196/251 (78%), Gaps = 2/251 (0%)
Frame = +1
Query: 55 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHAR 228
++WEL NN+ D++++YD I+ +KPW KD HYFKY ++SA ALLKMV HAR
Sbjct: 11 KTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHAR 70
Query: 229 RGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRT 408
GGNLEVMG++ GKV TMI+MDS ALPVEGTETRVNAQ+ AYE++ Y + ++GR
Sbjct: 71 SGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRL 130
Query: 409 ENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYP 588
EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP
Sbjct: 131 ENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYP 190
Query: 589 RNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYWXXXX 768
+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW
Sbjct: 191 KGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTL 250
Query: 769 XXXXXXXQPDY 801
DY
Sbjct: 251 SSSSLLTNADY 261
>sp|Q9FVU9|CSN5A_ARATH COP9 signalosome complex subunit 5a (Signalosome subunit 5a) (Jun
activation domain-binding homolog 2)
Length = 358
Score = 331 bits (849), Expect = 1e-90
Identities = 152/257 (59%), Positives = 193/257 (75%), Gaps = 6/257 (2%)
Frame = +1
Query: 55 QSWELENNVVTIN------DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMV 216
++WELEN+++T++ D++F YD + + KPW D HYFK +++SA ALLKMV
Sbjct: 11 KTWELENSILTVDSPDSTSDNIFYYDDTSQTRFQQEKPWENDPHYFKRVKISALALLKMV 70
Query: 217 THARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAK 396
HAR GG +E+MG++ GK +T+IVMD+ ALPVEGTETRVNAQ +AYE++ Y T
Sbjct: 71 VHARSGGTIEIMGLMQGKTDGDTIIVMDAFALPVEGTETRVNAQDDAYEYMVEYSQTNKL 130
Query: 397 IGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAF 576
GR ENV+GWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PF+AVV+DP RTVS+GKV IGAF
Sbjct: 131 AGRLENVVGWYHSHPGYGCWLSGIDVSTQRLNQQHQEPFLAVVIDPTRTVSAGKVEIGAF 190
Query: 577 RTYPRNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYW 756
RTY + Y PPD+ SEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD +LD+LWN+YW
Sbjct: 191 RTYSKGYKPPDEPVSEYQTIPLNKIEDFGVHCKQYYSLDVTYFKSSLDSHLLDLLWNKYW 250
Query: 757 XXXXXXXXXXXQPDYMA 807
DY+A
Sbjct: 251 VNTLSSSPLLGNGDYVA 267
>sp|Q8LAZ7|CSN5B_ARATH COP9 signalosome complex subunit 5b (Signalosome subunit 5b) (Jun
activation domain-binding homolog 1)
Length = 357
Score = 325 bits (834), Expect = 7e-89
Identities = 152/257 (59%), Positives = 189/257 (73%), Gaps = 6/257 (2%)
Frame = +1
Query: 55 QSWELENNVVTI------NDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMV 216
++WELENN++ + +D +F YD + I + KPW D +YFK + +SA ALLKMV
Sbjct: 11 KTWELENNILPVEPTDSASDSIFHYDDASQAKIQQEKPWASDPNYFKRVHISALALLKMV 70
Query: 217 THARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAK 396
HAR GG +E+MG++ GK +T+IVMD+ ALPVEGTETRVNAQS+AYE++ Y T
Sbjct: 71 VHARSGGTIEIMGLMQGKTEGDTIIVMDAFALPVEGTETRVNAQSDAYEYMVEYSQTSKL 130
Query: 397 IGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAF 576
GR ENV+GWYHSHPGYGCWLSGIDV+TQ +NQ YQ+PF+AVV+DP RTVS+GKV IGAF
Sbjct: 131 AGRLENVVGWYHSHPGYGCWLSGIDVSTQMLNQQYQEPFLAVVIDPTRTVSAGKVEIGAF 190
Query: 577 RTYPRNYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYW 756
RTYP + D SEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD +LD+LWN+YW
Sbjct: 191 RTYPEGHKISDDHVSEYQTIPLNKIEDFGVHCKQYYSLDITYFKSSLDSHLLDLLWNKYW 250
Query: 757 XXXXXXXXXXXQPDYMA 807
DY+A
Sbjct: 251 VNTLSSSPLLGNGDYVA 267
>sp|P91001|CSN5_CAEEL COP9 signalosome complex subunit 5 (Signalosome subunit 5) (JAB1
homolog)
Length = 368
Score = 323 bits (828), Expect = 3e-88
Identities = 148/234 (63%), Positives = 185/234 (79%)
Frame = +1
Query: 55 QSWELENNVVTINDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRG 234
++WE ENNV + D +F Y+ I +KPW KD HYFK I++SA ALLKM HA+RG
Sbjct: 15 RNWEKENNVQNV-DSIFEYNNKQQVEIRNAKPWDKDPHYFKQIKISAIALLKMTMHAKRG 73
Query: 235 GNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTEN 414
GNLE+MG+L G++ N+ I++D ALPVEGTETRVNAQ++AYE++T+Y + GR E
Sbjct: 74 GNLEIMGLLQGRIDANSFIILDVFALPVEGTETRVNAQAQAYEYMTVYSEMCDTEGRKEK 133
Query: 415 VIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRN 594
V+GWYHSHPGYGCWLSGIDV+TQT+NQ +Q+P+VA+V+DP+RT+S+GKV+IGAFRTYP
Sbjct: 134 VVGWYHSHPGYGCWLSGIDVSTQTLNQKFQEPWVAIVIDPLRTMSAGKVDIGAFRTYPEG 193
Query: 595 YSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYW 756
Y PPD PSEYQSIPL KIEDFGVHCK+YY L +S+FKS LD IL LWN YW
Sbjct: 194 YRPPDDVPSEYQSIPLAKIEDFGVHCKRYYSLDVSFFKSQLDAHILTSLWNSYW 247
>sp|O94454|CSN5_SCHPO COP9 signalosome complex subunit 5 (CSN complex subunit 5) (SGN5)
Length = 299
Score = 228 bits (582), Expect = 1e-59
Identities = 112/227 (49%), Positives = 148/227 (65%), Gaps = 6/227 (2%)
Frame = +1
Query: 94 DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKV 273
+++FR+D + ++ PW D +F+ +++SA ALLKM+ H +G LEVMG + GKV
Sbjct: 6 ENVFRFDEEKERAKIRESPWKHDPEFFRSVKISAVALLKMLRHVSQGMPLEVMGYVQGKV 65
Query: 274 THNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGC 453
++I++DS ALPVEGTETRVNA EA E+ Y + R ENVIGWYHSHP YGC
Sbjct: 66 EGASLIILDSFALPVEGTETRVNAHEEAQEYSVQYHTLCKSVYRHENVIGWYHSHPNYGC 125
Query: 454 WLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRNYSPPDQGPSE--- 624
WLSG+DV TQ NQ YQDPFVAVVLDP R++ S VNIGAFRTYP + S
Sbjct: 126 WLSGVDVETQRQNQKYQDPFVAVVLDPKRSLESPYVNIGAFRTYPVGNDGSIRTKSRHHP 185
Query: 625 ---YQSIPLNKIEDFGVHCKQYYPLIMSYFKSSLDKAILDILWNRYW 756
++++P +KIED G H + YY L ++YF S +K + + L NR W
Sbjct: 186 SVLFKNLPSSKIEDAGAHAEAYYSLPITYFHSKAEKKVTEFLRNRNW 232
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,594,795
Number of Sequences: 369166
Number of extensions: 1970531
Number of successful extensions: 4546
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4369
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4526
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)