Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02156
(771 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 114 2e-25
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 101 3e-21
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 100 3e-21
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 99 1e-20
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 96 8e-20
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 94 5e-19
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 89 1e-17
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 88 2e-17
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 70 5e-12
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 70 6e-12
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 114 bits (286), Expect = 2e-25
Identities = 71/216 (32%), Positives = 104/216 (48%), Gaps = 9/216 (4%)
Frame = +2
Query: 77 KYKFDFTKLPERLKCVLCHDILKNARQTTCGCKVCDKCIISY--LSGGPKVCPSNQTDCI 250
+Y+F +L ER KC CH +L N QT CG + C CI+S L+ P +CP +
Sbjct: 32 EYQF-VERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVP-ICP------V 83
Query: 251 NVMLNINEDIHQDNATNKEIGNLVVKCP-FDSCIYSCALRNMVEHIDSCEFREIIC--EK 421
+ + ++++ +DN +E+ NL V C C L +H+ C F+ + C EK
Sbjct: 84 DKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEK 143
Query: 422 CENKFRANEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNN 601
C + H C+ R C C KD+V I+L + LC +Y CPNN
Sbjct: 144 CREPVLRKDLKEHLSASCQFRKEKCLYC-----KKDVVVINLQNHEENLCPEYPVFCPNN 198
Query: 602 CNEKSKINLK----EHLKVCPNKKLECPFHQFECKI 697
C +KI LK EHL VCP + +CPF + C +
Sbjct: 199 C---AKIILKTEVDEHLAVCPEAEQDCPFKHYGCAV 231
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 101 bits (251), Expect = 3e-21
Identities = 66/232 (28%), Positives = 102/232 (43%), Gaps = 6/232 (2%)
Frame = +2
Query: 77 KYKFDFTKLPERLKCVLCHDILKNARQTTCGCKVCDKCIISY--LSGGPKVCPSNQTDCI 250
+Y+F +L ER KC CH +L N QT CG + C +CI S L+ P +CP +
Sbjct: 32 EYQF-VEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVP-ICP------V 83
Query: 251 NVMLNINEDIHQDNATNKEIGNLVVKCP-FDSCIYSCALRNMVEHIDSCEFREIIC--EK 421
+ + +++ +DN +E+ NL V C C L +H+ C F+ + C E
Sbjct: 84 DKEVIKPQEVFKDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCPNES 143
Query: 422 CENKFRANEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNN 601
C + H C R C C +D+V +L + C Y CPN
Sbjct: 144 CREAMLRKDVKEHLSAYCRFREEKCLYC-----KRDIVVTNLQDHEENSCPAYPVSCPNR 198
Query: 602 CNEK-SKINLKEHLKVCPNKKLECPFHQFECKIDKMTKEKLIIHMNEEYLNH 754
C + + + EHL VCP + +CPF + C + K + L+ H +H
Sbjct: 199 CVQTIPRARVNEHLTVCPEAEQDCPFKHYGCTV-KGKRGNLLEHERAALQDH 249
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 100 bits (250), Expect = 3e-21
Identities = 62/223 (27%), Positives = 100/223 (44%), Gaps = 1/223 (0%)
Frame = +2
Query: 101 LPERLKCVLCHDILKNARQTTCGCKVCDKCIISYLSGGPKVCPSNQTDCINVMLNINEDI 280
L + +C +C L+ A QT CG + C CII + CP ++ + + +
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCP------VDNEILLENQL 117
Query: 281 HQDNATNKEIGNLVVKCPFDSCIYSCALRNMVEHIDSCEFREIICEKCENKFRANEKVNH 460
DN +EI +L+VKCP + C++ LR++ +H CEF + C +C+ F+ H
Sbjct: 118 FPDNFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIH 177
Query: 461 DKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNNCNEKSKINLKEHL 640
C R V+C +C +M ++D IH D+ C IC + + H
Sbjct: 178 ILKDCPRRQVSCDNCAASMAFEDK-EIH-----DQNCPLANVICEYCNTILIREQMPNHY 231
Query: 641 KV-CPNKKLECPFHQFECKIDKMTKEKLIIHMNEEYLNHTSSL 766
+ CP + C F F C +KM + L H+ E +H L
Sbjct: 232 DLDCPTAPIPCTFSTFGCH-EKMQRNHLARHLQENTQSHMRML 273
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 99.4 bits (246), Expect = 1e-20
Identities = 61/219 (27%), Positives = 97/219 (44%), Gaps = 1/219 (0%)
Frame = +2
Query: 101 LPERLKCVLCHDILKNARQTTCGCKVCDKCIISYLSGGPKVCPSNQTDCINVMLNINEDI 280
L + +C +C L+ A QT CG + C CII + CP ++ + + +
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCP------VDNEILLENQL 117
Query: 281 HQDNATNKEIGNLVVKCPFDSCIYSCALRNMVEHIDSCEFREIICEKCENKFRANEKVNH 460
DN +EI +L VKCP C+ LR++ +H CEF + C +C+ F+ + H
Sbjct: 118 FPDNFAKREILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTH 177
Query: 461 DKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNNCNEKSKINLKEHL 640
+ C R V+C +C ++M Y++ IH D+ C IC + + H
Sbjct: 178 IIEDCPRRQVSCVNCAVSMAYEEK-EIH-----DQSCPLANIICEYCGTILIREQMPNHY 231
Query: 641 KV-CPNKKLECPFHQFECKIDKMTKEKLIIHMNEEYLNH 754
+ CP + C F F C KM + L H+ E H
Sbjct: 232 DLDCPTAPIPCTFSVFGCH-QKMQRNHLARHLQENTQLH 269
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 96.3 bits (238), Expect = 8e-20
Identities = 59/231 (25%), Positives = 104/231 (45%), Gaps = 6/231 (2%)
Frame = +2
Query: 95 TKLPERLKCVLCHDILKNARQTTCGCKVCDKCIISYLSGGPKVCPSNQTDCI---NVMLN 265
T+L + C C +IL+ Q CG + C C+ S LS GP+ C + + + + +
Sbjct: 26 TRLEAKYLCSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISIL 85
Query: 266 INEDIHQDNATNKEIGNLVVKCPFDSCIYSCALRNMVE-HIDSCEFREIICEKCENKFRA 442
+ DNA +E+ +L CP D C + L+ H C F C C+ R
Sbjct: 86 ESSSAFPDNAARREVESLPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRL 145
Query: 443 NEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNNCNEKS-- 616
+EK +H + +C R ++C+ C + D+ +H E+C K+ C + C +K
Sbjct: 146 SEKEHHTEQECPKRSLSCQHCRAPCSHVDL-EVHY-----EVCPKFPLTC-DGCGKKKIP 198
Query: 617 KINLKEHLKVCPNKKLECPFHQFECKIDKMTKEKLIIHMNEEYLNHTSSLI 769
+ ++H++ C ++ C FH C + + E L H + H + L+
Sbjct: 199 RETFQDHVRACSKCRVLCRFHTVGCS-EMVETENLQDHELQRLREHLALLL 248
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 93.6 bits (231), Expect = 5e-19
Identities = 60/231 (25%), Positives = 100/231 (43%), Gaps = 6/231 (2%)
Frame = +2
Query: 95 TKLPERLKCVLCHDILKNARQTTCGCKVCDKCIISYLSGGPKVCPSNQTDCI---NVMLN 265
TKL + C C ++L+ Q CG + C C+ S LS GP+ C + + I + +
Sbjct: 26 TKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISIL 85
Query: 266 INEDIHQDNATNKEIGNLVVKCPFDSCIYSCALRNMVE-HIDSCEFREIICEKCENKFRA 442
+ DNA +E+ +L CP D C + L+ H C C C+ R
Sbjct: 86 ESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRL 145
Query: 443 NEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNNCNEKS-- 616
EK H + +C R ++C+ C D+ H E+C K+ C + C +K
Sbjct: 146 GEKERHLEHECPERSLSCRHCRAPCCGADVKAHH------EVCPKFPLTC-DGCGKKKIP 198
Query: 617 KINLKEHLKVCPNKKLECPFHQFECKIDKMTKEKLIIHMNEEYLNHTSSLI 769
+ ++H+K C ++ C FH C ++ + EK H + H + L+
Sbjct: 199 REKFQDHVKTCGKCRVPCRFHAIGC-LETVEGEKQQEHEVQWLREHLAMLL 248
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 89.0 bits (219), Expect = 1e-17
Identities = 61/237 (25%), Positives = 106/237 (44%), Gaps = 8/237 (3%)
Frame = +2
Query: 80 YKFDFTKLPE-RLKCVLCHDILKNARQTTCGCKVCDKCIISYLSGGPKVCPSNQTDCINV 256
YK F K E + KC CH +L + +QT CG + C+ C+ + LS C + Q
Sbjct: 39 YKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESI--- 95
Query: 257 MLNINEDIHQDNATNKEIGNLVVKCPFDS--CIYSCALRNMVEHI-DSCEFREIICEK-- 421
+ + + +DN +EI L + C +S C L +++ H+ + C F E+ C +
Sbjct: 96 ---VKDKVFKDNCCKREILALQIYCRNESRGCAEQLTLGHLLVHLKNDCHFEELPCVRPD 152
Query: 422 CENKFRANEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNN 601
C+ K + +H + C+ R C C M+ + + D D C V CP+
Sbjct: 153 CKEKVLRKDLRDHVEKACKYREATCSHC---KSQVPMIALQKHEDTD--CPCVVVSCPHK 207
Query: 602 CNEKS--KINLKEHLKVCPNKKLECPFHQFECKIDKMTKEKLIIHMNEEYLNHTSSL 766
C+ ++ + L HL C N C F ++ C + + T +++ H + H + L
Sbjct: 208 CSVQTLLRSELSAHLSECVNAPSTCSFKRYGC-VFQGTNQQIKAHEASSAVQHVNLL 263
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 88.2 bits (217), Expect = 2e-17
Identities = 62/237 (26%), Positives = 105/237 (44%), Gaps = 8/237 (3%)
Frame = +2
Query: 80 YKFDFTKLPE-RLKCVLCHDILKNARQTTCGCKVCDKCIISYLSGGPKVCPSNQTDCINV 256
YK F K E + KC C +L N +QT CG + C+ C+ + LS C + Q
Sbjct: 38 YKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESI--- 94
Query: 257 MLNINEDIHQDNATNKEIGNLVVKCPFD--SCIYSCALRNMVEHI-DSCEFREIICEK-- 421
I + + +DN +EI L V C + C L +++ H+ + C+F E+ C +
Sbjct: 95 ---IKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRAD 151
Query: 422 CENKFRANEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNN 601
C+ K + +H + C+ R C C M+ + + D D C V CP+
Sbjct: 152 CKEKVLRKDLRDHVEKACKYREATCSHC---KSQVPMIKLQKHEDTD--CPCVVVSCPHK 206
Query: 602 CNEKS--KINLKEHLKVCPNKKLECPFHQFECKIDKMTKEKLIIHMNEEYLNHTSSL 766
C+ ++ + L HL C N C F ++ C + + T +++ H + H + L
Sbjct: 207 CSVQTLLRSELSAHLSECVNAPSTCSFKRYGC-VFQGTNQQIKAHEASSAVQHVNLL 262
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 70.5 bits (171), Expect = 5e-12
Identities = 51/222 (22%), Positives = 91/222 (40%), Gaps = 18/222 (8%)
Frame = +2
Query: 80 YKFDFTKLPERLKCVLCHDILKNARQ-TTCGCKVCDKCIISYLSGGPKVCPSNQTDCINV 256
YKF K RL C LC ++++ + +TCG + CD C+ +LS G CP +Q
Sbjct: 6 YKFP-EKPKRRLLCPLCGKPMRDSVEVSTCGHRYCDNCLQEFLSEGVFKCPEDQLPLDYA 64
Query: 257 MLNINEDIHQDNATNKEIGNLVVKC--PFDSCIYSCALRNMVEHIDSCEFREIIC-EKCE 427
I+ D ++ L ++C + C +S LR++ H+++C F + C +C
Sbjct: 65 ------KIYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCPNRCP 118
Query: 428 NKFRANEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNNCN 607
K + H + C R + C+ CG + + +C + C N C
Sbjct: 119 AKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGE------AYESHEGVCPQESVFCENKCG 172
Query: 608 EK--SKINLKEHLKVCPNKKLECPF------------HQFEC 691
+ ++ + CP + C + HQ++C
Sbjct: 173 ARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQC 214
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 70.1 bits (170), Expect = 6e-12
Identities = 53/222 (23%), Positives = 89/222 (40%), Gaps = 18/222 (8%)
Frame = +2
Query: 80 YKFDFTKLPERLKCVLCHDILKNARQ-TTCGCKVCDKCIISYLSGGPKVCPSNQTDCINV 256
YKF K RL C LC ++ Q +TCG + CD C+ +LS G CP +Q
Sbjct: 6 YKF-LEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYA 64
Query: 257 MLNINEDIHQDNATNKEIGNLVVKC--PFDSCIYSCALRNMVEHIDSCEFREIIC-EKCE 427
I+ D ++ L ++C + C +S LR++ H+++C F I C +C
Sbjct: 65 ------KIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCP 118
Query: 428 NKFRANEKVNHDKDQCEMRMVNCKSCGLAMKYKDMVNIHLNADRDELCSKYVSICPNNCN 607
K + H + C R + C+ CG + + +C + C N C
Sbjct: 119 MKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGE------AYESHEGMCPQESVYCENKCG 172
Query: 608 EK--SKINLKEHLKVCPNKKLECPF------------HQFEC 691
+ ++ + CP + C + HQ++C
Sbjct: 173 ARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQC 214
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,183,649
Number of Sequences: 369166
Number of extensions: 1973306
Number of successful extensions: 6013
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5362
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5911
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)