Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02134
(558 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 70 3e-12
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 69 1e-11
sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) ... 68 2e-11
sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G) 61 2e-09
sp|O15084|ANR28_HUMAN Ankyrin repeat domain protein 28 59 8e-09
sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TN... 59 1e-08
sp|Q02989|LITA_LATMA Alpha-latroinsectotoxin precursor (Alp... 58 1e-08
sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4... 58 1e-08
sp|Q04861|NFKB1_CHICK Nuclear factor NF-kappa-B p105 subuni... 57 2e-08
sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (T... 57 3e-08
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 70.5 bits (171), Expect = 3e-12
Identities = 47/157 (29%), Positives = 80/157 (50%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + ++ +L+ +G S N+ +SV+ V+PLHLAA T V L S+Q+
Sbjct: 601 PLHIAAKQNQIEVARSLLQYGGSANA----ESVQGVTPLHLAAQEGHTEMVALLLSKQA- 655
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
N N L + + +V ++ G V+A + T LH+ASH G+
Sbjct: 656 --NGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTVDA----TTRMGYTPLHVASHYGN 709
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
+++V+ LL++ AD A+ + G P+H A + GH
Sbjct: 710 IKLVKFLLQHQADVNAK----TKLGYSPLHQAAQQGH 742
Score = 57.0 bits (136), Expect = 3e-08
Identities = 49/191 (25%), Positives = 84/191 (43%), Gaps = 30/191 (15%)
Frame = +1
Query: 52 EQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTS 231
+++ P+H A +NG +I E L+ G+ I + K+ +SP+H+AA D V L
Sbjct: 267 DELTPLHCAARNGHVRISEILLDHGAPIQA----KTKNGLSPIHMAAQGDHLDCVRLLLQ 322
Query: 232 QQSASINI------------------------------NSTRSDSFNALLTLVSKKNVAG 321
+ +I NS + F L K ++
Sbjct: 323 YNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRV 382
Query: 322 VKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGI 501
++ +L +GA ++A V+ S T LH+AS +G + IV+ LL+ GA P + +
Sbjct: 383 MELLLKTGASIDA---VTES-GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---- 434
Query: 502 LPIHLATESGH 534
P+H+A +GH
Sbjct: 435 TPLHMAARAGH 445
Score = 52.4 bits (124), Expect = 8e-07
Identities = 39/158 (24%), Positives = 74/158 (46%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+HVA + G ++ E L+ + N+ ++PLH+A ++ V L + +
Sbjct: 535 PLHVAAKYGKVRLAELLLEHDAHPNAA----GKNGLTPLHVAVHHNNLDIVKLLLPRGGS 590
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+S + + L + + +++L G NA+ V + T LH+A+ G
Sbjct: 591 P---HSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESV----QGVTPLHLAAQEGH 643
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
E+V LLL A+ G++ G+ P+HL ++ GH+
Sbjct: 644 TEMVALLLSKQANGNL----GNKSGLTPLHLVSQEGHV 677
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/182 (23%), Positives = 82/182 (45%), Gaps = 25/182 (13%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+H+A G D+++ L+++G+++N+ +S + +PL++AA + V FL +
Sbjct: 78 LHIAALAGQDEVVRELVNYGANVNA----QSQKGFTPLYMAAQENHLEVVKFLLENGA-- 131
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGA----------------DVNAKCVVSR 378
N N D F L + + + V ++N G D V+ +
Sbjct: 132 -NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 190
Query: 379 S---------RNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESG 531
+ T LHIA+H ++ + +LLL GA + ++GI P+H+A+ G
Sbjct: 191 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS----VNFTPQNGITPLHIASRRG 246
Query: 532 HL 537
++
Sbjct: 247 NV 248
Score = 49.3 bits (116), Expect = 6e-06
Identities = 35/160 (21%), Positives = 76/160 (47%)
Frame = +1
Query: 58 VLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQ 237
+ P+H+A + G ++ L+ G+ I + ++ + ++PLH AA N L
Sbjct: 236 ITPLHIASRRGNVIMVRLLLDRGAQIET----RTKDELTPLHCAARNGHVRISEILLDHG 291
Query: 238 SASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHV 417
+ I + + + + ++ V+ +L A+++ + + T LH+A+H
Sbjct: 292 AP---IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITL----DHLTPLHVAAHC 344
Query: 418 GSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
G + ++LL+ GA P +R + +G P+H+A + H+
Sbjct: 345 GHHRVAKVLLDKGAKPNSRAL----NGFTPLHIACKKNHI 380
Score = 46.6 bits (109), Expect = 4e-05
Identities = 43/187 (22%), Positives = 72/187 (38%), Gaps = 30/187 (16%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H A + G +++ L+ G+S N L + +PLH AA T + L ++++
Sbjct: 469 PLHCAARIGHTGMVKLLLENGASPN----LATTAGHTPLHTAAREGHVDTALALLEKEAS 524
Query: 244 SINI------------------------------NSTRSDSFNALLTLVSKKNVAGVKTI 333
+ N+ + L V N+ VK +
Sbjct: 525 QACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 584
Query: 334 LNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIH 513
L G ++ T LHIA+ +E+ R LL+YG A + G+ P+H
Sbjct: 585 LPRGGSPHSPAW----NGYTPLHIAAKQNQIEVARSLLQYGGSANAESV----QGVTPLH 636
Query: 514 LATESGH 534
LA + GH
Sbjct: 637 LAAQEGH 643
Score = 42.4 bits (98), Expect = 8e-04
Identities = 41/156 (26%), Positives = 71/156 (45%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+ A LDK ++ L + G IN+ + ++ LHLA+ V+ L ++
Sbjct: 13 LRAARSGNLDKALDHLRN-GVDINTC----NQNGLNGLHLASKEGHVKMVVELLHKE--- 64
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSV 426
I + +T AL V+ ++N GA+VNA+ + T L++A+ +
Sbjct: 65 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS----QKGFTPLYMAAQENHL 120
Query: 427 EIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
E+V+ LLE GA+ DG P+ +A + GH
Sbjct: 121 EVVKFLLENGAN----QNVATEDGFTPLAVALQQGH 152
Score = 39.3 bits (90), Expect = 0.007
Identities = 26/97 (26%), Positives = 47/97 (48%)
Frame = +1
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSV 426
++IN+ + N L + +V V +L+ + + + T LHIA+ G
Sbjct: 32 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET----TTKKGNTALHIAALAGQD 87
Query: 427 EIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
E+VR L+ YGA+ A+ + G P+++A + HL
Sbjct: 88 EVVRELVNYGANVNAQ----SQKGFTPLYMAAQENHL 120
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 68.6 bits (166), Expect = 1e-11
Identities = 46/157 (29%), Positives = 79/157 (50%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + ++ +L+ +G S N+ +SV+ V+PLHLAA V L S+Q+
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANA----ESVQGVTPLHLAAQEGHAEMVALLLSKQA- 659
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
N N L + + +V ++ G V+A + T LH+ASH G+
Sbjct: 660 --NGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA----TTRMGYTPLHVASHYGN 713
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
+++V+ LL++ AD A+ + G P+H A + GH
Sbjct: 714 IKLVKFLLQHQADVNAK----TKLGYSPLHQAAQQGH 746
Score = 57.8 bits (138), Expect = 2e-08
Identities = 45/158 (28%), Positives = 79/158 (50%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + +++E L+ G+SI++ + ++PLH+A+ V L Q+ A
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAV----TESGLTPLHVASFMGHLPIVKNLL-QRGA 428
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
S N+++ + ++ + VA K +L + A VNAK + T LH A+ +G
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVA--KYLLQNKAKVNAKA----KDDQTPLHCAARIGH 482
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
+V+LLLE A+P G P+H+A GH+
Sbjct: 483 TNMVKLLLENNANPNLATTAGH----TPLHIAAREGHV 516
Score = 57.4 bits (137), Expect = 2e-08
Identities = 50/191 (26%), Positives = 84/191 (43%), Gaps = 30/191 (15%)
Frame = +1
Query: 52 EQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTS 231
+++ P+H A +NG +I E L+ G+ I + K+ +SP+H+AA D V L
Sbjct: 271 DELTPLHCAARNGHVRISEILLDHGAPIQA----KTKNGLSPIHMAAQGDHLDCVRLLLQ 326
Query: 232 QQSASINI------------------------------NSTRSDSFNALLTLVSKKNVAG 321
+ +I NS + F L K +V
Sbjct: 327 YDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRV 386
Query: 322 VKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGI 501
++ +L +GA ++A V+ S T LH+AS +G + IV+ LL+ GA P + +
Sbjct: 387 MELLLKTGASIDA---VTES-GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---- 438
Query: 502 LPIHLATESGH 534
P+H+A +GH
Sbjct: 439 TPLHMAARAGH 449
Score = 52.0 bits (123), Expect = 1e-06
Identities = 40/158 (25%), Positives = 73/158 (46%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+HVA + G ++ E L+ + N+ ++PLH+A ++ V L + +
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAA----GKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+S + + L + V +++L G NA+ V + T LH+A+ G
Sbjct: 595 P---HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESV----QGVTPLHLAAQEGH 647
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
E+V LLL A+ G++ G+ P+HL + GH+
Sbjct: 648 AEMVALLLSKQANGNL----GNKSGLTPLHLVAQEGHV 681
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/182 (23%), Positives = 82/182 (45%), Gaps = 25/182 (13%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+H+A G D+++ L+++G+++N+ +S + +PL++AA + V FL +
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNA----QSQKGFTPLYMAAQENHLEVVKFLLENGA-- 135
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGA----------------DVNAKCVVSR 378
N N D F L + + + V ++N G D V+ +
Sbjct: 136 -NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 379 S---------RNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESG 531
+ T LHIA+H ++ + +LLL GA + ++GI P+H+A+ G
Sbjct: 195 NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS----VNFTPQNGITPLHIASRRG 250
Query: 532 HL 537
++
Sbjct: 251 NV 252
Score = 49.7 bits (117), Expect = 5e-06
Identities = 36/160 (22%), Positives = 76/160 (47%)
Frame = +1
Query: 58 VLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQ 237
+ P+H+A + G ++ L+ G+ I + K+ + ++PLH AA N L
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIET----KTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 238 SASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHV 417
+ I + + + + ++ V+ +L A+++ + + T LH+A+H
Sbjct: 296 AP---IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITL----DHLTPLHVAAHC 348
Query: 418 GSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
G + ++LL+ GA P +R + +G P+H+A + H+
Sbjct: 349 GHHRVAKVLLDKGAKPNSRAL----NGFTPLHIACKKNHV 384
Score = 49.3 bits (116), Expect = 6e-06
Identities = 42/157 (26%), Positives = 68/157 (43%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + G + + L+ +S + M K +PLH+AA L + +
Sbjct: 506 PLHIAAREGHVETVLALLEKEAS-QACMTKKGF---TPLHVAAKYGKVRVAELLLERDA- 560
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+ N+ + L V N+ VK +L G ++ T LHIA+
Sbjct: 561 --HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW----NGYTPLHIAAKQNQ 614
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
VE+ R LL+YG A + G+ P+HLA + GH
Sbjct: 615 VEVARSLLQYGGSANAESV----QGVTPLHLAAQEGH 647
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/156 (28%), Positives = 71/156 (45%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+HVA G I++ L+ G+S N + +V+ +PLH+AA T +L ++
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPN----VSNVKVETPLHMAARAGHTEVAKYLLQNKA- 461
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+N+ D L + VK +L + A+ N ++ + T LHIA+ G
Sbjct: 462 --KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN----LATTAGHTPLHIAAREGH 515
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESG 531
VE V LLE A + G P+H+A + G
Sbjct: 516 VETVLALLEKEASQACM----TKKGFTPLHVAAKYG 547
Score = 42.4 bits (98), Expect = 8e-04
Identities = 41/156 (26%), Positives = 71/156 (45%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+ A LDK ++ L + G IN+ + ++ LHLA+ V+ L ++
Sbjct: 17 LRAARSGNLDKALDHLRN-GVDINTC----NQNGLNGLHLASKEGHVKMVVELLHKE--- 68
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSV 426
I + +T AL V+ ++N GA+VNA+ + T L++A+ +
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS----QKGFTPLYMAAQENHL 124
Query: 427 EIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
E+V+ LLE GA+ DG P+ +A + GH
Sbjct: 125 EVVKFLLENGAN----QNVATEDGFTPLAVALQQGH 156
Score = 39.3 bits (90), Expect = 0.007
Identities = 26/97 (26%), Positives = 47/97 (48%)
Frame = +1
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSV 426
++IN+ + N L + +V V +L+ + + + T LHIA+ G
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET----TTKKGNTALHIAALAGQD 91
Query: 427 EIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
E+VR L+ YGA+ A+ + G P+++A + HL
Sbjct: 92 EVVRELVNYGANVNAQ----SQKGFTPLYMAAQENHL 124
>sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
Length = 3924
Score = 67.8 bits (164), Expect = 2e-11
Identities = 49/164 (29%), Positives = 85/164 (51%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + K++E L+ +G+SI + + ++P+H+AA + V+ L Q A
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAI----TESGLTPIHVAAFMGHLNIVLLLL-QNGA 455
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
S ++ + R ++ AL V V+ +L +GA V+A+ T LHIAS +G
Sbjct: 456 SPDVTNIRGET--ALHMAARAGQVEVVRCLLRNGALVDARA----REEQTPLHIASRLGK 509
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHLGNCSTI 555
EIV+LLL++ A P A +G P+H++ G + S +
Sbjct: 510 TEIVQLLLQHMAHPDA----ATTNGYTPLHISAREGQVDVASVL 549
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/158 (28%), Positives = 78/158 (49%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H A ++G D+++E L+ G+ + + ++ +SPLH+AA D V L ++
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPL----LARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
++ D AL + K +L+ A+ NA+ + T LHIA
Sbjct: 358 ---VDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARAL----NGFTPLHIACKKNR 410
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
++++ LL++YGA + IT G+ PIH+A GHL
Sbjct: 411 IKVMELLVKYGAS--IQAIT--ESGLTPIHVAAFMGHL 444
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/157 (28%), Positives = 79/157 (50%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + +I TL+++G+ N + + + V+PLHLA+ T V L + A
Sbjct: 632 PLHIAAKKNQMQIASTLLNYGAETN----IVTKQGVTPLHLASQEGHTDMVTLLLDK-GA 686
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+I++++ + L K NVA + T + D + K T L +A H G+
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL------GYTPLIVACHYGN 740
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
V++V LL+ GA+ A+ ++G P+H A + GH
Sbjct: 741 VKMVNFLLKQGANVNAKT----KNGYTPLHQAAQQGH 773
Score = 52.8 bits (125), Expect = 6e-07
Identities = 39/138 (28%), Positives = 67/138 (48%)
Frame = +1
Query: 124 GSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSASININSTRSDSFNALLTLVS 303
GSS KS S L A +L V +L I+IN+ + NAL
Sbjct: 18 GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYL----KGGIDINTCNQNGLNALHLAAK 73
Query: 304 KKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMIT 483
+ +V V+ +L G+ V++ + + T LHIAS G E+V++L++ GA+ A+
Sbjct: 74 EGHVGLVQELLGRGSSVDS----ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ--- 126
Query: 484 GDRDGILPIHLATESGHL 537
++G P+++A + H+
Sbjct: 127 -SQNGFTPLYMAAQENHI 143
Score = 52.4 bits (124), Expect = 8e-07
Identities = 39/154 (25%), Positives = 73/154 (47%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+HVA + G + + L+ ++ +S ++PLH+AA D + L + ++
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSA----GKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
++T + + L K + T+LN GA+ N + + T LH+AS G
Sbjct: 622 P---HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETN----IVTKQGVTPLHLASQEGH 674
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATE 525
++V LLL+ GA+ + + G+ +HLA +
Sbjct: 675 TDMVTLLLDKGAN----IHMSTKSGLTSLHLAAQ 704
Score = 52.0 bits (123), Expect = 1e-06
Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 33/189 (17%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+H+A G ++++ L+ G++IN+ +S +PL++AA + V +L +
Sbjct: 101 LHIASLAGQAEVVKVLVKEGANINA----QSQNGFTPLYMAAQENHIDVVKYLLENGA-- 154
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNS---------------------------- 342
N ++ D F L + + + V +L +
Sbjct: 155 -NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 343 ---GADVNAKCVVSRSRNA--TCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILP 507
ADV +K +V+R+ + T LHIA+H G+V + LLL GA A T R+GI P
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA---AVDFTA-RNGITP 269
Query: 508 IHLATESGH 534
+H+A++ G+
Sbjct: 270 LHVASKRGN 278
Score = 51.6 bits (122), Expect = 1e-06
Identities = 40/160 (25%), Positives = 76/160 (47%)
Frame = +1
Query: 58 VLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQ 237
+ P+HVA + G +++ L+ G I++ K+ + ++PLH AA + V L +
Sbjct: 267 ITPLHVASKRGNTNMVKLLLDRGGQIDA----KTRDGLTPLHCAARSGHDQVVELLLERG 322
Query: 238 SASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHV 417
+ + + + + L +V VK +L A V+ + T LH+A+H
Sbjct: 323 APLL---ARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTL----DYLTALHVAAHC 375
Query: 418 GSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
G + +LLL+ A+P AR + +G P+H+A + +
Sbjct: 376 GHYRVTKLLLDKRANPNARAL----NGFTPLHIACKKNRI 411
Score = 50.4 bits (119), Expect = 3e-06
Identities = 39/157 (24%), Positives = 72/157 (45%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H++ + G + L+ G++ + L + + +PLH+AA L +++A
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHS----LATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+ +S + L N +L GA +A + T LHIA+
Sbjct: 589 A---DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHA----TAKNGYTPLHIAAKKNQ 641
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
++I LL YGA+ ++T + G+ P+HLA++ GH
Sbjct: 642 MQIASTLLNYGAE--TNIVT--KQGVTPLHLASQEGH 674
Score = 46.2 bits (108), Expect = 5e-05
Identities = 44/189 (23%), Positives = 82/189 (43%), Gaps = 26/189 (13%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQS-- 240
+H+A + G +++ L+ G+ +++ ++ E +PLH+A+ T V L +
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDA----RAREEQTPLHIASRLGKTEIVQLLLQHMAHP 523
Query: 241 ----------ASININSTRSDSFNALL------TLVSKKNVAGVKTILNSGADVNAKCVV 372
I+ + D + LL +L +KK + G+ AK ++
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Query: 373 SRSRNA--------TCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATES 528
R A T LH+A+H + ++ LLLE GA P A ++G P+H+A +
Sbjct: 584 QRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA----KNGYTPLHIAAKK 639
Query: 529 GHLGNCSTI 555
+ ST+
Sbjct: 640 NQMQIASTL 648
Score = 40.4 bits (93), Expect = 0.003
Identities = 44/192 (22%), Positives = 82/192 (42%), Gaps = 29/192 (15%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+H+A + G +++ L+ GSS++S + + + LH+A+L V L +
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSA----TKKGNTALHIASLAGQAEVVKVLVKE---G 120
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNA------------------KCVV 372
NIN+ + F L + ++ VK +L +GA+ + + V
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 373 SRSRNAT-------CLHIASHVGSVEIVRLLL--EYGADPFARMITG--DRDGILPIHLA 519
N T LHIA+ + LLL ++ AD ++M+ G P+H+A
Sbjct: 181 ILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIA 240
Query: 520 TESGHLGNCSTI 555
G++ N +T+
Sbjct: 241 AHYGNV-NVATL 251
Score = 38.1 bits (87), Expect = 0.015
Identities = 40/153 (26%), Positives = 68/153 (44%), Gaps = 3/153 (1%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALND---LTSTVIFLTSQ 234
P+HVA K+ L+ G+S ++T + +PLH+AA + + ST++
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHAT----AKNGYTPLHIAAKKNQMQIASTLL----N 650
Query: 235 QSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASH 414
A NI + + + L L S++ + T+L D A +S T LH+A+
Sbjct: 651 YGAETNIVTKQGVT---PLHLASQEGHTDMVTLL---LDKGANIHMSTKSGLTSLHLAAQ 704
Query: 415 VGSVEIVRLLLEYGADPFARMITGDRDGILPIH 513
V + +L ++GAD A G I+ H
Sbjct: 705 EDKVNVADILTKHGADQDAHTKLGYTPLIVACH 737
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
Length = 4377
Score = 60.8 bits (146), Expect = 2e-09
Identities = 40/157 (25%), Positives = 74/157 (47%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + I TL+ +G+ N+ + + ++ +HLAA V L + +
Sbjct: 634 PLHIAAKKNQMDIATTLLEYGADANAV----TRQGIASVHLAAQEGHVDMVSLLLGRNA- 688
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
N+N + L + V + ++N GA V+A+ + T LH+ H G+
Sbjct: 689 --NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY----TPLHVGCHYGN 742
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
++IV LL++ A A+ ++G P+H A + GH
Sbjct: 743 IKIVNFLLQHSAKVNAK----TKNGYTPLHQAAQQGH 775
Score = 57.8 bits (138), Expect = 2e-08
Identities = 44/164 (26%), Positives = 79/164 (48%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H ++G ++++E L+ + I S K+ +SPLH+A D + V L
Sbjct: 304 PLHCGARSGHEQVVEMLLDRAAPILS----KTKNGLSPLHMATQGDHLNCVQLLLQH--- 356
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
++ ++ +D AL + K +L+ A+ NAK + T LHIA
Sbjct: 357 NVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKAL----NGFTPLHIACKKNR 412
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHLGNCSTI 555
++++ LLL++GA + +T G+ PIH+A GH+ S +
Sbjct: 413 IKVMELLLKHGAS--IQAVT--ESGLTPIHVAAFMGHVNIVSQL 452
Score = 54.3 bits (129), Expect = 2e-07
Identities = 48/164 (29%), Positives = 77/164 (46%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H++ + G + + L+ G+S++ T + + +PLH+AA V L Q+SA
Sbjct: 535 PLHLSAREGHEDVAAFLLDHGASLSIT----TKKGFTPLHVAAKYGKLE-VANLLLQKSA 589
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
S + + L N +L+ GA +A + T LHIA+
Sbjct: 590 SPD--AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHA----AAKNGYTPLHIAAKKNQ 643
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHLGNCSTI 555
++I LLEYGAD A +T R GI +HLA + GH+ S +
Sbjct: 644 MDIATTLLEYGAD--ANAVT--RQGIASVHLAAQEGHVDMVSLL 683
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/164 (24%), Positives = 75/164 (45%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H++ + G I++ L+ G+S N+ + +PLHL+A FL A
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAA----TTSGYTPLHLSAREGHEDVAAFLLDH-GA 556
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
S++I + + + + K VA + ++ D K T LH+A+H +
Sbjct: 557 SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKS------GLTPLHVAAHYDN 610
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHLGNCSTI 555
++ LLL+ GA P A ++G P+H+A + + +T+
Sbjct: 611 QKVALLLLDQGASPHA----AAKNGYTPLHIAAKKNQMDIATTL 650
Score = 50.4 bits (119), Expect = 3e-06
Identities = 48/178 (26%), Positives = 74/178 (41%), Gaps = 26/178 (14%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTS---- 231
PIHVA G I+ L+H G+S N+T +V + LH+AA + V +L
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTT----NVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Query: 232 --------QQSASININSTRSDSFNALLTLVSKKNVAGVK--TILNSGA----------- 348
Q I+ ++D LL + N A T L+ A
Sbjct: 492 VEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFL 551
Query: 349 -DVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLA 519
D A ++ + T LH+A+ G +E+ LLL+ A P A + G+ P+H+A
Sbjct: 552 LDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA----AGKSGLTPLHVA 605
Score = 46.6 bits (109), Expect = 4e-05
Identities = 36/160 (22%), Positives = 76/160 (47%)
Frame = +1
Query: 58 VLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQ 237
+ P+HVA + G +++ L+ G+ I++ K+ + ++PLH A + V L +
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 238 SASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHV 417
+ I S + + L ++ V+ +L V+ + T LH+A+H
Sbjct: 325 AP---ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT----NDYLTALHVAAHC 377
Query: 418 GSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
G ++ ++LL+ A+P A+ + +G P+H+A + +
Sbjct: 378 GHYKVAKVLLDKKANPNAKAL----NGFTPLHIACKKNRI 413
Score = 46.2 bits (108), Expect = 5e-05
Identities = 35/128 (27%), Positives = 61/128 (47%)
Frame = +1
Query: 154 KSVERVSPLHLAALNDLTSTVIFLTSQQSASININSTRSDSFNALLTLVSKKNVAGVKTI 333
KS S L A L + ++ + ++IN + NAL + +V V +
Sbjct: 38 KSDANASYLRAARAGHLEKALDYIKN----GVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 334 LNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIH 513
L A+V+A + + T LHIAS G E+V++L+ GA+ A+ ++G P++
Sbjct: 94 LQREANVDA----ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ----SQNGFTPLY 145
Query: 514 LATESGHL 537
+A + HL
Sbjct: 146 MAAQENHL 153
Score = 40.0 bits (92), Expect = 0.004
Identities = 41/181 (22%), Positives = 79/181 (43%), Gaps = 25/181 (13%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+H+A G ++++ L+ G+++N+ +S +PL++AA + V FL ++
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNA----QSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGA----------------DVNAKCVVSR 378
+ D F L + + + V +L + D A ++ +
Sbjct: 167 ---SLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Query: 379 SRNA---------TCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESG 531
+ N T LHIA+H G++ + LLL A A T R+ I P+H+A++ G
Sbjct: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAA---AVDFTA-RNDITPLHVASKRG 279
Query: 532 H 534
+
Sbjct: 280 N 280
>sp|O15084|ANR28_HUMAN Ankyrin repeat domain protein 28
Length = 1086
Score = 58.9 bits (141), Expect = 8e-09
Identities = 50/180 (27%), Positives = 85/180 (47%)
Frame = +1
Query: 1 LIFTDVDIQVRSRWGQGEQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPL 180
L+ + +D+ VR+ G+ P+ +A G + ++ LI+ G+SI ++ + + +P+
Sbjct: 602 LVQSLLDLDVRNSSGR----TPLDLAAFKGHVECVDVLINQGASI---LVKDYILKRTPI 654
Query: 181 HLAALNDLTSTVIFLTSQQSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNA 360
H AA N + + L ++ + L+ V + V ++LN GA+V+A
Sbjct: 655 HAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA 714
Query: 361 KCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHLG 540
K R T LH + G E V LL++GA R D G PIHL+ GH+G
Sbjct: 715 KDKWGR----TALHRGAVTGHEECVDALLQHGAKCLLR----DSRGRTPIHLSAACGHIG 766
Score = 55.5 bits (132), Expect = 9e-08
Identities = 42/166 (25%), Positives = 79/166 (47%)
Frame = +1
Query: 34 SRWGQGEQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTST 213
S+W + P+H AV + ++ ++ L+ + +N+ + +PLH+AA N
Sbjct: 105 SKW-----LTPLHRAVASCSEEAVQVLLKHSADVNA----RDKNWQTPLHIAAANKAVKC 155
Query: 214 VIFLTSQQSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNAT 393
L S N+N + AL + VK +L+ GA++NA ++
Sbjct: 156 AEALVPLLS---NVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA----FDKKDRR 208
Query: 394 CLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESG 531
+H A+++G +E+V+LL+ +GA+ + D+ P+H A SG
Sbjct: 209 AIHWAAYMGHIEVVKLLVSHGAEVTCK----DKKSYTPLHAAASSG 250
Score = 42.0 bits (97), Expect = 0.001
Identities = 37/158 (23%), Positives = 66/158 (41%), Gaps = 1/158 (0%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H A +G+ +++ L+ G +N + +PLH+A N V L
Sbjct: 242 PLHAAASSGMISVVKYLLDLGVDMNEPNAYGN----TPLHVACYNGQDVVVNELID---C 294
Query: 244 SININSTRSDSFNAL-LTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVG 420
+N F L S ++ ++ +GADVN K + T LH+ + G
Sbjct: 295 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK----TPLHMTALHG 350
Query: 421 SVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
+ +++ GA + D++G P+H+A GH
Sbjct: 351 RFSRSQTIIQSGAV----IDCEDKNGNTPLHIAARYGH 384
Score = 41.6 bits (96), Expect = 0.001
Identities = 39/152 (25%), Positives = 61/152 (40%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A + G + +I TLI G+ + + + PLHLAAL+ +
Sbjct: 375 PLHIAARYGHELLINTLITSGADTAK----RGIHGMFPLHLAALSGFSDCC--------- 421
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+ +L+SG D++ R TCLH A+ G+
Sbjct: 422 ---------------------------RKLLSSGFDIDTPDDFGR----TCLHAAAAGGN 450
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLA 519
+E + LLL GAD D+ G P+H A
Sbjct: 451 LECLNLLLNTGAD----FNKKDKFGRSPLHYA 478
Score = 39.7 bits (91), Expect = 0.005
Identities = 41/158 (25%), Positives = 63/158 (39%), Gaps = 2/158 (1%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVE--RVSPLHLAALNDLTSTVIFLTSQQS 240
+H A NG + +E L+ + + E SPLH A +ND L
Sbjct: 793 LHWACYNGHETCVELLLE-------QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLG 845
Query: 241 ASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVG 420
ASI +N+T S L +V ++ +L+ A VN+ S T L +A+ G
Sbjct: 846 ASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS----VDSTGKTPLMMAAENG 900
Query: 421 SVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
V +L+ + A + D +HLA GH
Sbjct: 901 QTNTVEMLVSSAS---AELTLQDNSKNTALHLACSKGH 935
Score = 30.0 bits (66), Expect = 4.0
Identities = 37/145 (25%), Positives = 60/145 (41%)
Frame = +1
Query: 16 VDIQVRSRWGQGEQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAAL 195
VDIQ G P+ ++V NG + +L++ G+++++ K + LH A+
Sbjct: 679 VDIQ------DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA----KDKWGRTALHRGAV 728
Query: 196 NDLTSTVIFLTSQQSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVS 375
V L Q A + +R + L V G +L S A ++A +
Sbjct: 729 TGHEECVDALL-QHGAKCLLRDSRGRTPIHLSAACGHIGVLGA--LLQSAASMDANPATA 785
Query: 376 RSRNATCLHIASHVGSVEIVRLLLE 450
+ T LH A + G V LLLE
Sbjct: 786 DNHGYTALHWACYNGHETCVELLLE 810
>sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TNKS-1) (TRF1-interacting
ankyrin-related ADP-ribose polymerase)
Length = 1327
Score = 58.5 bits (140), Expect = 1e-08
Identities = 50/174 (28%), Positives = 80/174 (45%), Gaps = 15/174 (8%)
Frame = +1
Query: 58 VLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQ 237
++P+H A G +++ L+ G+ N+ + +PLH AA+ I L Q
Sbjct: 250 LIPLHNACSFGHAEVVSLLLCQGADPNA----RDNWNYTPLHEAAIKGKIDVCIVLL-QH 304
Query: 238 SASININST--------RSDSFNALLTLVSKKNV-------AGVKTILNSGADVNAKCVV 372
A NI +T S A+LT KK+ + ++ +N C
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364
Query: 373 SRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
S R +T LH+A+ V IV+LLL++GAD A+ D+ G++P+H A GH
Sbjct: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK----DKGGLVPLHNACSYGH 414
Score = 57.0 bits (136), Expect = 3e-08
Identities = 52/199 (26%), Positives = 90/199 (45%), Gaps = 20/199 (10%)
Frame = +1
Query: 1 LIFTDVDIQVRSRWGQGEQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPL 180
L+ D+ + + G ++P+H A G ++ E L+ G+S+N + K +PL
Sbjct: 703 LLHHGADVHAKDKGG----LVPLHNACSYGHYEVAELLVRHGASVNVADLWK----FTPL 754
Query: 181 HLAAL--------------------NDLTSTVIFLTSQQSASININSTRSDSFNALLTLV 300
H AA N +T + L + I + + D+ ALL
Sbjct: 755 HEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQ-DLLKGDA--ALLDAA 811
Query: 301 SKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMI 480
K +A V+ + N C ++ RN+T LH+A+ ++E+ LLE+GAD A+
Sbjct: 812 KKGCLARVQKLCTPE---NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ-- 866
Query: 481 TGDRDGILPIHLATESGHL 537
D+ G++P+H A GH+
Sbjct: 867 --DKGGLIPLHNAASYGHV 883
Score = 50.8 bits (120), Expect = 2e-06
Identities = 45/177 (25%), Positives = 71/177 (40%), Gaps = 20/177 (11%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQS- 240
P+HVA + + ++E L G+ +N+ L + LH AAL T L S S
Sbjct: 561 PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ----TALHRAALAGHLQTCRLLLSYGSD 616
Query: 241 -------------------ASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAK 363
I ST + + L+ ++T+ + N
Sbjct: 617 PSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVN 676
Query: 364 CVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
C R++T LH A+ V +V LL +GAD A+ D+ G++P+H A GH
Sbjct: 677 CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK----DKGGLVPLHNACSYGH 729
Score = 42.7 bits (99), Expect = 6e-04
Identities = 30/89 (33%), Positives = 48/89 (53%)
Frame = +1
Query: 268 SDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLL 447
S + LL +V+ VK ++++ A+VNAK + R + LH A+ G ++V LL
Sbjct: 180 SGALRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSP--LHFAAGFGRKDVVEHLL 236
Query: 448 EYGADPFARMITGDRDGILPIHLATESGH 534
+ GA+ AR D G++P+H A GH
Sbjct: 237 QMGANVHAR----DDGGLIPLHNACSFGH 261
Score = 40.0 bits (92), Expect = 0.004
Identities = 40/141 (28%), Positives = 62/141 (43%)
Frame = +1
Query: 103 IETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSASININSTRSDSFN 282
+ET+ SS N +PLH AA + S V +L + ++++
Sbjct: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGA---DVHAKDKGGLV 719
Query: 283 ALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGAD 462
L S + + ++ GA VN V+ T LH A+ G EI +LLL++GAD
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVN----VADLWKFTPLHEAAAKGKYEICKLLLKHGAD 775
Query: 463 PFARMITGDRDGILPIHLATE 525
P + +RDG P+ L E
Sbjct: 776 PTKK----NRDGNTPLDLVKE 792
Score = 35.8 bits (81), Expect = 0.073
Identities = 28/104 (26%), Positives = 44/104 (42%)
Frame = +1
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+IN T+ + L N+ + +L GADVNA+ LH A+ G
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ----DKGGLIPLHNAASYGH 882
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHLGNCSTI 555
V+I LL++Y A D+ P+H A + G C+ +
Sbjct: 883 VDIAALLIKYNTCVNAT----DKWAFTPLHEAAQKGRTQLCALL 922
Score = 30.8 bits (68), Expect = 2.4
Identities = 32/120 (26%), Positives = 50/120 (41%)
Frame = +1
Query: 106 ETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSASININSTRSDSFNA 285
E L+ + +N + +PLHLAA + V L + ++++
Sbjct: 349 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGA---DVHAKDKGGLVP 405
Query: 286 LLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADP 465
L S + + +L GA VNA + T LH A+ VE+ LLL +GADP
Sbjct: 406 LHNACSYGHYEVTELLLKHGACVNAMDLWQ----FTPLHEAASKNRVEVCSLLLSHGADP 461
Score = 30.0 bits (66), Expect = 4.0
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 8/144 (5%)
Frame = +1
Query: 19 DIQVRSRWGQGEQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALN 198
D+ + + G ++P+H A G I LI + + +N+T +PLH AA
Sbjct: 862 DVNAQDKGG----LIPLHNAASYGHVDIAALLIKYNTCVNAT----DKWAFTPLHEAAQK 913
Query: 199 DLTSTVIFLTS--------QQSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADV 354
T L + Q ++ +D AL L+ + T A V
Sbjct: 914 GRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRAL--LIDAMPPEALPTCFKPQATV 971
Query: 355 NAKCVVSRSRNATCLHIASHVGSV 426
+ ++S + +CL AS + ++
Sbjct: 972 VSASLISPASTPSCLSAASSIDNL 995
>sp|Q02989|LITA_LATMA Alpha-latroinsectotoxin precursor (Alpha-LIT)
Length = 1411
Score = 58.2 bits (139), Expect = 1e-08
Identities = 49/158 (31%), Positives = 77/158 (48%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A+ + + E L+ S N + L++ ++PLHLA+ VI L ++ +
Sbjct: 706 PLHLAILFKKNDVAERLL---SDENLNIRLETNGGINPLHLASATGNKQLVIELLAKNA- 761
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
++ S F+AL + KN ++ GA+VN K + T LH A+ +G
Sbjct: 762 --DVTRLTSKGFSALHLGIIGKNEEIPFFLVEKGANVNDKT----NSGVTPLHFAAGLGK 815
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
I RLLL GAD A D + +PIH A +GHL
Sbjct: 816 ANIFRLLLSRGADIKAE----DINSQMPIHEAVSNGHL 849
Score = 57.0 bits (136), Expect = 3e-08
Identities = 45/161 (27%), Positives = 77/161 (47%), Gaps = 3/161 (1%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAA---LNDLTSTVIFLTSQ 234
P+H+A + + + LI + +N + + +PLHLAA L D+T T+I +T
Sbjct: 537 PLHIAADSNKNDFVMFLIGNNADVN---VRTKSDLFTPLHLAARRDLTDVTQTLIDIT-- 591
Query: 235 QSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASH 414
I++N+ F L +S + I N+ A +N K V T LH+A+
Sbjct: 592 ---EIDLNAQDKSGFTPLHLSISSTSETAAILIRNTNAVINIKSKV----GLTPLHLATL 644
Query: 415 VGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
++ + +LL G A + GD +G+ P+H A +G+L
Sbjct: 645 QNNLSVSKLLAGKG----AYLNDGDANGMTPLHYAAMTGNL 681
Score = 40.4 bits (93), Expect = 0.003
Identities = 41/160 (25%), Positives = 70/160 (43%)
Frame = +1
Query: 58 VLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQ 237
V P+H A G I L+ G+ I + + + P+H A N V L +
Sbjct: 804 VTPLHFAAGLGKANIFRLLLSRGADIKA----EDINSQMPIHEAVSNGHLEIVRILIEKD 859
Query: 238 SASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHV 417
+ +N+ + R++ V K+ ++ A+VN V + N T LH+ S
Sbjct: 860 PSLMNVKNIRNEY--PFYLAVEKRYKDIFDYFVSKDANVNE---VDHNGN-TLLHLFSST 913
Query: 418 GSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
G +E+V+ L++ GA+ R+ +R LA E+G L
Sbjct: 914 GELEVVQFLMQNGAN--FRLKNNERKTF--FDLAIENGRL 949
Score = 34.3 bits (77), Expect = 0.21
Identities = 29/100 (29%), Positives = 44/100 (44%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
PI VA+ I+ L+ G+ N + V+ PL++AA V L
Sbjct: 1084 PITVAIFANKVSILNYLVGIGADPN-----QQVDGDPPLYIAARQGRFEIVRCLIEVHK- 1137
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAK 363
++IN+ + F AL + VK ++ GADVNAK
Sbjct: 1138 -VDINTRNKERFTALHAAARNDFMDVVKYLVRQGADVNAK 1176
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
serine/threonine-protein kinase 4) (Ankyrin repeat domain
protein 3) (PKC-delta-interacting protein kinase)
Length = 832
Score = 58.2 bits (139), Expect = 1e-08
Identities = 45/158 (28%), Positives = 71/158 (44%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+HVA Q+G + I+ L+ G ++ L+ + PLH AA V L Q
Sbjct: 588 PMHVACQHGQENIVRILLRRGVDVS----LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGV 643
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
S+N + D L + + + +++ +DVN ++++ T LH+A+ G
Sbjct: 644 SVNAQTL--DGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ----TPLHVAAETGH 697
Query: 424 VEIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
RLLL GA A DG +HLA +GHL
Sbjct: 698 TSTARLLLHRGAGKEAM----TSDGYTALHLAARNGHL 731
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/165 (29%), Positives = 74/165 (44%), Gaps = 1/165 (0%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+A Q G ++ LI S +N +L +PLH+AA TST L + +
Sbjct: 655 PLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ----TPLHVAAETGHTSTARLLLHRGAG 710
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
+ SD + AL ++A VK ++ ADV A+ + N T LH+A+ G
Sbjct: 711 K---EAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPL----NQTALHLAAAHGH 763
Query: 424 VEIVRLLLEYGA-DPFARMITGDRDGILPIHLATESGHLGNCSTI 555
E+V L+ D F D G+ +HLA + H T+
Sbjct: 764 SEVVEELVSADVIDLF------DEQGLSALHLAAQGRHAQTVETL 802
Score = 51.6 bits (122), Expect = 1e-06
Identities = 42/157 (26%), Positives = 72/157 (45%)
Frame = +1
Query: 67 IHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSAS 246
+H+AV+ G ++ + L+ ++ N L + +PLH+A + V L +++
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPN----LSNRRGSTPLHMAVERRVRGVVELLLARK--- 542
Query: 247 ININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSV 426
I++N+ D + AL + + + +L A VN R T +H+A G
Sbjct: 543 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR----TPMHVACQHGQE 598
Query: 427 EIVRLLLEYGADPFARMITGDRDGILPIHLATESGHL 537
IVR+LL G D + +D LP+H A GHL
Sbjct: 599 NIVRILLRRGVD----VSLQGKDAWLPLHYAAWQGHL 631
Score = 47.4 bits (111), Expect = 2e-05
Identities = 45/159 (28%), Positives = 81/159 (50%), Gaps = 2/159 (1%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALN-DLTSTVIFLTSQQS 240
P+H+AV+ + ++E L+ S+N+ K ++ + LH AA N D +ST + L +++
Sbjct: 522 PLHMAVERRVRGVVELLLARKISVNA----KDEDQWTALHFAAQNGDESSTRLLL--EKN 575
Query: 241 ASININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATC-LHIASHV 417
AS+N + + ++N+ V+ +L G DV+ + ++A LH A+
Sbjct: 576 ASVNEVDFEGRTPMHVACQHGQENI--VRILLRRGVDVSL-----QGKDAWLPLHYAAWQ 628
Query: 418 GSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
G + IV+LL + P + DG P+HLA + GH
Sbjct: 629 GHLPIVKLLAK---QPGVSVNAQTLDGRTPLHLAAQRGH 664
>sp|Q04861|NFKB1_CHICK Nuclear factor NF-kappa-B p105 subunit [Contains: Nuclear factor
NF-kappa-B p50 subunit]
Length = 984
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/157 (28%), Positives = 78/157 (49%), Gaps = 1/157 (0%)
Frame = +1
Query: 64 PIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAALNDLTSTVIFLTSQQSA 243
P+H+AV +++E L+ G+++N L S LHLAA + L Q A
Sbjct: 583 PLHLAVITKQAEVVEDLLKAGANVN----LLDRHGNSVLHLAAAEGDDKILSLLLKHQKA 638
Query: 244 SININSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGS 423
S I+ + + +A+ +V+ +++ +K ++ +G DVNA+ + T LH+A +
Sbjct: 639 SSMIDLSNGEGLSAIHMVVTANSLSCLKLLIAAGVDVNAQ---EQKSGRTALHLAVEQEN 695
Query: 424 VEIVR-LLLEYGADPFARMITGDRDGILPIHLATESG 531
V + LLLE AD + + DG P+H+A G
Sbjct: 696 VPLAGCLLLEGDAD----VDSTTYDGTTPLHIAAGRG 728
>sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (TNKS-2) (TRF1-interacting
ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like
protein) (Tankyrase-related protein)
Length = 1166
Score = 57.0 bits (136), Expect = 3e-08
Identities = 51/193 (26%), Positives = 85/193 (44%), Gaps = 15/193 (7%)
Frame = +1
Query: 1 LIFTDVDIQVRSRWGQGEQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPL 180
L+ ++Q R G ++P+H A G +++ L+ G+ N+ + +PL
Sbjct: 77 LLQNGANVQARDDGG----LIPLHNACSFGHAEVVNLLLRHGADPNA----RDNWNYTPL 128
Query: 181 HLAALNDLTSTVIFLTSQQSASININST--------RSDSFNALLT-------LVSKKNV 315
H AA+ I L Q A I +T S A+LT L+
Sbjct: 129 HEAAIKGKIDVCIVLL-QHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187
Query: 316 AGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRD 495
+ ++ +N C S R +T LH+A+ V+IV+LLL++GAD A+ D+
Sbjct: 188 GNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK----DKG 243
Query: 496 GILPIHLATESGH 534
++P+H A GH
Sbjct: 244 DLVPLHNACSYGH 256
Score = 53.5 bits (127), Expect = 3e-07
Identities = 52/193 (26%), Positives = 88/193 (45%), Gaps = 20/193 (10%)
Frame = +1
Query: 19 DIQVRSRWGQGEQVLPIHVAVQNGLDKIIETLIHFGSSINSTMILKSVERVSPLHLAAL- 195
D+ + + G ++P+H A G ++ E L+ G+ +N + K +PLH AA
Sbjct: 551 DVHAKDKGG----LVPLHNACSYGHYEVAELLVKHGAVVNVADLWK----FTPLHEAAAK 602
Query: 196 -------------------NDLTSTVIFLTSQQSASININSTRSDSFNALLTLVSKKNVA 318
N +T + L I + R D+ ALL K +A
Sbjct: 603 GKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQ-DLLRGDA--ALLDAAKKGCLA 659
Query: 319 GVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDG 498
VK + S D N C ++ R++T LH+A+ ++E+ LL++GAD A+ D+ G
Sbjct: 660 RVKKL--SSPD-NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ----DKGG 712
Query: 499 ILPIHLATESGHL 537
++P+H A GH+
Sbjct: 713 LIPLHNAASYGHV 725
Score = 46.6 bits (109), Expect = 4e-05
Identities = 44/177 (24%), Positives = 77/177 (43%), Gaps = 16/177 (9%)
Frame = +1
Query: 52 EQVLPIHVAVQNGLDKIIETLIHFGSSINSTMIL--KSVERVSPL-HLAALNDLTS---- 210
E + P+HVA + + ++E ++ + +N+ L S+ R + HL L S
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCD 458
Query: 211 -TVIFL---TSQQSASININSTRSDSFN-----ALLTLVSKKNVAGVKTILNSGADVNAK 363
+I L T+ Q + N+ + + A L+ V+T+ +
Sbjct: 459 PNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVN 518
Query: 364 CVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
C R +T LH A+ V +V LL++GAD A+ D+ G++P+H A GH
Sbjct: 519 CRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK----DKGGLVPLHNACSYGH 571
Score = 38.1 bits (87), Expect = 0.015
Identities = 34/118 (28%), Positives = 55/118 (46%)
Frame = +1
Query: 172 SPLHLAALNDLTSTVIFLTSQQSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGAD 351
+PLH AA + S V +L + ++++ L S + + ++ GA
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGA---DVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
Query: 352 VNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATE 525
VN V+ T LH A+ G EI +LLL++GADP + +RDG P+ L +
Sbjct: 585 VN----VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKK----NRDGNTPLDLVKD 634
Score = 36.6 bits (83), Expect = 0.043
Identities = 20/51 (39%), Positives = 29/51 (56%)
Frame = +1
Query: 382 RNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLATESGH 534
R +T LH A+ G ++V LL+ GA+ AR D G++P+H A GH
Sbjct: 57 RKSTPLHFAAGFGRKDVVEYLLQNGANVQAR----DDGGLIPLHNACSFGH 103
Score = 34.7 bits (78), Expect = 0.16
Identities = 23/72 (31%), Positives = 34/72 (47%)
Frame = +1
Query: 250 NINSTRSDSFNALLTLVSKKNVAGVKTILNSGADVNAKCVVSRSRNATCLHIASHVGSVE 429
NIN + L K + V+ ++ A VNA + + T LH A++ G ++
Sbjct: 392 NINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQ----TSLHRAAYCGHLQ 447
Query: 430 IVRLLLEYGADP 465
RLLL YG DP
Sbjct: 448 TCRLLLSYGCDP 459
Score = 31.6 bits (70), Expect = 1.4
Identities = 29/98 (29%), Positives = 43/98 (43%)
Frame = +1
Query: 172 SPLHLAALNDLTSTVIFLTSQQSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGAD 351
+PLHLAA + V L + ++++ L S + + ++ GA
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGA---DVHAKDKGDLVPLHNACSYGHYEVTELLVKHGAC 269
Query: 352 VNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADP 465
VNA + T LH A+ VE+ LLL YGADP
Sbjct: 270 VNAMDLWQ----FTPLHEAASKNRVEVCSLLLSYGADP 303
Score = 30.0 bits (66), Expect = 4.0
Identities = 30/117 (25%), Positives = 51/117 (43%)
Frame = +1
Query: 172 SPLHLAALNDLTSTVIFLTSQQSASININSTRSDSFNALLTLVSKKNVAGVKTILNSGAD 351
+PLHLAA + +L + ++N+ L S +V ++ A
Sbjct: 681 TPLHLAAGYNNLEVAEYLLQHGA---DVNAQDKGGLIPLHNAASYGHVDVAALLIKYNAC 737
Query: 352 VNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPIHLAT 522
VNA + T LH A+ G ++ LLL +GADP + +++G P+ L +
Sbjct: 738 VNA----TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLK----NQEGQTPLDLVS 786
Score = 29.3 bits (64), Expect = 6.9
Identities = 21/72 (29%), Positives = 33/72 (45%)
Frame = +1
Query: 331 ILNSGADVNAKCVVSRSRNATCLHIASHVGSVEIVRLLLEYGADPFARMITGDRDGILPI 510
+L GA++N K T LH+AS ++V +++++ A A D G +
Sbjct: 386 LLRKGANINEKT----KEFLTPLHVASEKAHNDVVEVVVKHEAKVNAL----DNLGQTSL 437
Query: 511 HLATESGHLGNC 546
H A GHL C
Sbjct: 438 HRAAYCGHLQTC 449
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,232,317
Number of Sequences: 369166
Number of extensions: 1081658
Number of successful extensions: 3969
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3137
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3661
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3980545740
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)