Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02123
(790 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8WXI2|CNKR2_HUMAN Connector enhancer of kinase suppress... 85 3e-16
sp|Q80YA9|CNKR2_MOUSE Connector enhancer of kinase suppress... 85 3e-16
sp|Q9Z1T4|CNKR2_RAT Connector enhancer of kinase suppressor... 85 3e-16
sp|Q969H4|CNKR1_HUMAN Connector enhancer of kinase suppress... 68 3e-11
sp|Q06321|ATG26_YEAST Sterol 3-beta-glucosyltransferase (Au... 39 0.012
sp|Q05193|DYN1_HUMAN Dynamin-1 38 0.036
sp|P39053|DYN1_MOUSE Dynamin-1 38 0.036
sp|P21575|DYN1_RAT Dynamin-1 (D100) (Dynamin, brain) (B-dyn... 38 0.036
sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2 37 0.047
sp|O08967|CYH3_MOUSE Cytohesin-3 (ARF nucleotide-binding si... 37 0.081
>sp|Q8WXI2|CNKR2_HUMAN Connector enhancer of kinase suppressor of ras 2 (Connector
enhancer of KSR2) (CNK2)
Length = 1034
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/107 (44%), Positives = 64/107 (59%), Gaps = 3/107 (2%)
Frame = +2
Query: 98 RSISCKDLGKGDCEGWLWIKKI--SILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINL 271
R ISCKDLG+GDCEGWLW KK S K+ + W VLK Y YI+ E+E+AE I+L
Sbjct: 561 RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL 620
Query: 272 EDFKICPMESFKSKNFYFKIYNSKV-NFTFAIESQTGFMKWLNKLQI 409
+FKI S K + FK + K+ +F FA E +WLN++ +
Sbjct: 621 PEFKI-DRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINM 666
>sp|Q80YA9|CNKR2_MOUSE Connector enhancer of kinase suppressor of ras 2 (Connector
enhancer of KSR2) (CNK2)
Length = 1032
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/107 (44%), Positives = 64/107 (59%), Gaps = 3/107 (2%)
Frame = +2
Query: 98 RSISCKDLGKGDCEGWLWIKKI--SILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINL 271
R ISCKDLG+GDCEGWLW KK S K+ + W VLK Y YI+ E+E+AE I+L
Sbjct: 561 RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL 620
Query: 272 EDFKICPMESFKSKNFYFKIYNSKV-NFTFAIESQTGFMKWLNKLQI 409
+FKI S K + FK + K+ +F FA E +WLN++ +
Sbjct: 621 PEFKI-DRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINM 666
>sp|Q9Z1T4|CNKR2_RAT Connector enhancer of kinase suppressor of ras 2 (Connector
enhancer of KSR2) (CNK2) (Membrane-associated guanylate
kinase-interacting protein) (MAGUIN)
Length = 1032
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/107 (44%), Positives = 64/107 (59%), Gaps = 3/107 (2%)
Frame = +2
Query: 98 RSISCKDLGKGDCEGWLWIKKI--SILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINL 271
R ISCKDLG+GDCEGWLW KK S K+ + W VLK Y YI+ E+E+AE I+L
Sbjct: 561 RRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISL 620
Query: 272 EDFKICPMESFKSKNFYFKIYNSKV-NFTFAIESQTGFMKWLNKLQI 409
+FKI S K + FK + K+ +F FA E +WLN++ +
Sbjct: 621 PEFKI-DRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINM 666
>sp|Q969H4|CNKR1_HUMAN Connector enhancer of kinase suppressor of ras 1 (Connector
enhancer of KSR1) (hCNK1) (Connector enhancer of
KSR-like) (CNK homolog protein 1)
Length = 720
Score = 67.8 bits (164), Expect = 3e-11
Identities = 42/157 (26%), Positives = 73/157 (46%), Gaps = 2/157 (1%)
Frame = +2
Query: 98 RSISCKDLGKGDCEGWLWIKKI--SILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINL 271
R +SC++LG+ DC+GWL ++K + ++ RRW VLK H Y Y ++E+AE +IN+
Sbjct: 394 RRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINV 453
Query: 272 EDFKICPMESFKSKNFYFKIYNSKVNFTFAIESQTGFMKWLNKLQISASNIDLESIEGQI 451
++ + K K + ++ F FA ++ T W+ L S Q
Sbjct: 454 SNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKY-------QS 506
Query: 452 AGFIPGYTKVNPLETLQETDSNESAGYSESEDSDVQS 562
G P + + + D ++ AG + S Q+
Sbjct: 507 PGRAPPpreEDCYSETEAEDPDDEAGSHSASPSPAQA 543
>sp|Q06321|ATG26_YEAST Sterol 3-beta-glucosyltransferase (Autophagy-related protein 26)
(UDP-glycosyltransferase 51)
Length = 1198
Score = 39.3 bits (90), Expect = 0.012
Identities = 28/96 (29%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Frame = +2
Query: 188 RRWCVLKSHCFYVYIHIENERAEMIINLEDFKICPMESFK-----SKNFYFKIYNSKVNF 352
R WCVLK+H F +Y E ++ ++ ++ +E+ K S FK+Y + F
Sbjct: 256 RYWCVLKNHLFSMYTS-STELYFPVLTIDLREVQKIETQKHTLNGSATKTFKLYTDESTF 314
Query: 353 TFAIESQTGFMKWLNKL---QISASNIDLESIEGQI 451
F +S+ W+N L Q +A N + SI +I
Sbjct: 315 KFNADSEFSAKSWVNALKKEQFAAQNSENNSISLKI 350
>sp|Q05193|DYN1_HUMAN Dynamin-1
Length = 864
Score = 37.7 bits (86), Expect = 0.036
Identities = 32/145 (22%), Positives = 61/145 (42%), Gaps = 4/145 (2%)
Frame = +2
Query: 137 EGWLWIKKISILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINLEDFKICPME-SFKSK 313
+GWL I I I+K W VL + Y E + + ++++++ K+ +E F S
Sbjct: 523 KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSS 582
Query: 314 NFYFKIYNSKVNFTFAIESQTGFMKWLNKLQISASNIDLESIEGQIAGFIPGYT---KVN 484
F ++N++ Q K +L+++ E ++ A F+ +V
Sbjct: 583 KHIFALFNTE---------QRNVYKDYRQLELACET--QEEVDSWKASFLRAGVYPERVG 631
Query: 485 PLETLQETDSNESAGYSESEDSDVQ 559
E ET+ N S + S D ++
Sbjct: 632 DKEKASETEENGSDSFMHSMDPQLE 656
>sp|P39053|DYN1_MOUSE Dynamin-1
Length = 867
Score = 37.7 bits (86), Expect = 0.036
Identities = 32/145 (22%), Positives = 61/145 (42%), Gaps = 4/145 (2%)
Frame = +2
Query: 137 EGWLWIKKISILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINLEDFKICPME-SFKSK 313
+GWL I I I+K W VL + Y E + + ++++++ K+ +E F S
Sbjct: 523 KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSS 582
Query: 314 NFYFKIYNSKVNFTFAIESQTGFMKWLNKLQISASNIDLESIEGQIAGFIPGYT---KVN 484
F ++N++ Q K +L+++ E ++ A F+ +V
Sbjct: 583 KHIFALFNTE---------QRNVYKDYRQLELACET--QEEVDSWKASFLRAGVYPERVG 631
Query: 485 PLETLQETDSNESAGYSESEDSDVQ 559
E ET+ N S + S D ++
Sbjct: 632 DKEKASETEENGSDSFMHSMDPQLE 656
>sp|P21575|DYN1_RAT Dynamin-1 (D100) (Dynamin, brain) (B-dynamin)
Length = 851
Score = 37.7 bits (86), Expect = 0.036
Identities = 32/145 (22%), Positives = 61/145 (42%), Gaps = 4/145 (2%)
Frame = +2
Query: 137 EGWLWIKKISILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINLEDFKICPME-SFKSK 313
+GWL I I I+K W VL + Y E + + ++++++ K+ +E F S
Sbjct: 523 KGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSS 582
Query: 314 NFYFKIYNSKVNFTFAIESQTGFMKWLNKLQISASNIDLESIEGQIAGFIPGYT---KVN 484
F ++N++ Q K +L+++ E ++ A F+ +V
Sbjct: 583 KHIFALFNTE---------QRNVYKDYRQLELACET--QEEVDSWKASFLRAGVYPERVG 631
Query: 485 PLETLQETDSNESAGYSESEDSDVQ 559
E ET+ N S + S D ++
Sbjct: 632 DKEKASETEENGSDSFMHSMDPQLE 656
>sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2
Length = 589
Score = 37.4 bits (85), Expect = 0.047
Identities = 21/77 (27%), Positives = 41/77 (53%)
Frame = +2
Query: 140 GWLWIKKISILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINLEDFKICPMESFKSKNF 319
GW+ +K+ + + ++W VL S+ +Y ++E A++ + L+D I +E KS+ F
Sbjct: 28 GWVMLKEDKMKYLPWTKKWLVLSSNSLSIYKGSKSESAQVTLLLKD--IQKVERSKSRTF 85
Query: 320 YFKIYNSKVNFTFAIES 370
FK+ F I++
Sbjct: 86 CFKLRFKSSTKNFEIQA 102
>sp|O08967|CYH3_MOUSE Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein)
(General receptor of phosphoinositides 1) (Grp1) (CLM-3)
Length = 399
Score = 36.6 bits (83), Expect = 0.081
Identities = 22/69 (31%), Positives = 35/69 (50%)
Frame = +2
Query: 131 DCEGWLWIKKISILKNKFVRRWCVLKSHCFYVYIHIENERAEMIINLEDFKICPMESFKS 310
D EGWL K+ + RRW +L +C Y + + ++ II LE+ I +E +
Sbjct: 266 DREGWLL--KLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRK 323
Query: 311 KNFYFKIYN 337
N F++YN
Sbjct: 324 PN-CFELYN 331
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,030,799
Number of Sequences: 369166
Number of extensions: 1635616
Number of successful extensions: 5057
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4792
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5043
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)