Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_02120 (297 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q24746|NEUR_DROVI Neuralized protein 56 2e-08 sp|P29503|NEUR_DROME Neuralized protein 56 2e-08 sp|O76050|NEUL1_HUMAN Neuralized-like protein 1 (h-neuraliz... 48 6e-06 sp|Q923S6|NEURL_MOUSE Neuralized-like protein 1 (m-neuraliz... 48 6e-06 sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of ap... 38 0.008 sp|O10296|IAP1_NPVOP Apoptosis inhibitor 1 (IAP-1) 37 0.014 sp|P41435|IAP1_NPVAC Apoptosis inhibitor 1 (IAP-1) 37 0.018 sp|Q6UWE0|LRSM1_HUMAN Ubiquitin ligase protein LRSAM1 (Leuc... 36 0.024 sp|O15151|MDM4_HUMAN Mdm4 protein (p53-binding protein Mdm4... 35 0.040 sp|Q6TEM9|MYLIP_BRARE Ubiquitin ligase MYLIP (Myosin regula... 35 0.069
>sp|Q24746|NEUR_DROVI Neuralized protein Length = 747 Score = 56.2 bits (134), Expect = 2e-08 Identities = 21/47 (44%), Positives = 34/47 (72%) Frame = +1 Query: 16 DSLMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVFTS 156 DS++Y CGH+C+CY C+I+ GG CP+CRA ++++IR +T+ Sbjct: 703 DSVLYMCGHMCMCYDCAIEQWRGVGGG--QCPLCRAVIRDVIRTYTT 747
>sp|P29503|NEUR_DROME Neuralized protein Length = 754 Score = 56.2 bits (134), Expect = 2e-08 Identities = 21/47 (44%), Positives = 34/47 (72%) Frame = +1 Query: 16 DSLMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVFTS 156 DS++Y CGH+C+CY C+I+ GG CP+CRA ++++IR +T+ Sbjct: 710 DSVLYMCGHMCMCYDCAIEQWRGVGGG--QCPLCRAVIRDVIRTYTT 754
>sp|O76050|NEUL1_HUMAN Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67) Length = 574 Score = 48.1 bits (113), Expect = 6e-06 Identities = 17/47 (36%), Positives = 31/47 (65%) Frame = +1 Query: 16 DSLMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVFTS 156 D+++Y CGH+CLCY C ++ + + CP+CR +++II+ + S Sbjct: 530 DTVIYTCGHMCLCYACGLRLKKALHA---CCPICRRPIKDIIKTYRS 573
>sp|Q923S6|NEURL_MOUSE Neuralized-like protein 1 (m-neuralized 1) (m-neu1) Length = 574 Score = 48.1 bits (113), Expect = 6e-06 Identities = 17/47 (36%), Positives = 31/47 (65%) Frame = +1 Query: 16 DSLMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVFTS 156 D+++Y CGH+CLCY C ++ + + CP+CR +++II+ + S Sbjct: 530 DTVIYTCGHMCLCYSCGLRLKKALHA---CCPICRRPIKDIIKTYRS 573
>sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of apoptosis 2) (dIAP2) (DIAP) (IAP homolog A) (IAP-like protein) (DILP) Length = 498 Score = 37.7 bits (86), Expect = 0.008 Identities = 16/41 (39%), Positives = 21/41 (51%) Frame = +1 Query: 34 CGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVFTS 156 CGHL C C+ NCP+CRAD++ +R F S Sbjct: 466 CGHLATCNQCA--------PSVANCPMCRADIKGFVRTFLS 498
>sp|O10296|IAP1_NPVOP Apoptosis inhibitor 1 (IAP-1) Length = 275 Score = 37.0 bits (84), Expect = 0.014 Identities = 16/47 (34%), Positives = 25/47 (53%) Frame = +1 Query: 16 DSLMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVFTS 156 D+++ C H C+C C F L+ CP CR DV + I++F + Sbjct: 236 DAVLLPCRHFCVCMQC--YFALDGK-----CPTCRQDVADFIKIFVT 275
>sp|P41435|IAP1_NPVAC Apoptosis inhibitor 1 (IAP-1) Length = 286 Score = 36.6 bits (83), Expect = 0.018 Identities = 15/45 (33%), Positives = 22/45 (48%) Frame = +1 Query: 16 DSLMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVF 150 D+++ C H C+C C G CP CR DV + I++F Sbjct: 247 DAVLMPCRHFCVCVQCYF-------GLDQKCPTCRQDVTDFIKIF 284
>sp|Q6UWE0|LRSM1_HUMAN Ubiquitin ligase protein LRSAM1 (Leucine-rich repeat and sterile alpha motif containing 1) (Tsg101-associated ligase) (hTAL) Length = 723 Score = 36.2 bits (82), Expect = 0.024 Identities = 14/45 (31%), Positives = 22/45 (48%) Frame = +1 Query: 22 LMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVFTS 156 + CGH+C C C R CP+CR D+ + +R++ S Sbjct: 686 IFLNCGHVCCCQQCCQPLR--------TCPLCRQDIAQRLRIYHS 722
>sp|O15151|MDM4_HUMAN Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein) Length = 490 Score = 35.4 bits (80), Expect = 0.040 Identities = 15/40 (37%), Positives = 26/40 (65%) Frame = +1 Query: 31 RCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVF 150 R GHL C+ C+ + + GA +CP+C+ ++Q +I+VF Sbjct: 453 RTGHLVTCFHCARRLK---KAGA-SCPICKKEIQLVIKVF 488
>sp|Q6TEM9|MYLIP_BRARE Ubiquitin ligase MYLIP (Myosin regulatory light chain interacting protein) (MIR) Length = 472 Score = 34.7 bits (78), Expect = 0.069 Identities = 14/45 (31%), Positives = 24/45 (53%) Frame = +1 Query: 16 DSLMYRCGHLCLCYPCSIQFRLNSNGGAMNCPVCRADVQEIIRVF 150 D+ CGH+ C C+ Q + +CPVCR++V+ + V+ Sbjct: 393 DAAFCPCGHMVCCQNCAAQLQ--------SCPVCRSEVEHVQHVY 429
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 33,947,802 Number of Sequences: 369166 Number of extensions: 630211 Number of successful extensions: 1823 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 1780 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 1807 length of database: 68,354,980 effective HSP length: 68 effective length of database: 55,793,000 effective search space used: 1673790000 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)