Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02044
(895 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q6DD51|CSKI2_XENLA Caskin-2 111 2e-24
sp|Q8VHK2|CSKI1_RAT Caskin-1 (CASK interacting protein 1) 111 3e-24
sp|Q6P9K8|CSKI1_MOUSE Caskin-1 (CASK-interacting protein 1) 111 3e-24
sp|Q8VHK1|CSKI2_MOUSE Caskin-2 110 4e-24
sp|Q8WXD9|CSKI1_HUMAN Caskin-1 (CASK interacting protein 1) 110 7e-24
sp|Q8WXE0|CSKI2_HUMAN Caskin-2 109 1e-23
sp|P54755|EPHA5_CHICK Ephrin type-A receptor 5 precursor (T... 45 2e-04
sp|P59672|ANKS1_MOUSE Ankyrin repeat and SAM domain-contain... 45 3e-04
sp|P54753|EPHB3_HUMAN Ephrin type-B receptor 3 precursor (T... 44 6e-04
sp|P54754|EPHB3_MOUSE Ephrin type-B receptor 3 precursor (T... 44 8e-04
>sp|Q6DD51|CSKI2_XENLA Caskin-2
Length = 1205
Score = 111 bits (278), Expect = 2e-24
Identities = 54/129 (41%), Positives = 78/129 (60%)
Frame = +1
Query: 418 WLSFVGLGNYSDVLSNAGYDLATLAKATPEDLNASGVTNPKDRQLMKTHLNRLSVCDGLP 597
WL + Y +AGYDL T+ + TPEDL A GVT P R+++ T + +L V DGLP
Sbjct: 476 WLRGFQMETYVGNFISAGYDLPTIMRVTPEDLTAIGVTKPGHRKMISTEIGKLIVADGLP 535
Query: 598 ETMPVSIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADIGVEKLGHQKKLSLAI 777
+ +PV + D+L L L +Y + L + + + + LTWE L +IG+ +LGHQKKL L +
Sbjct: 536 QQIPVDLWDWLSQLGLPEYHKQLSENGYESLSTVTELTWEGLQEIGIHRLGHQKKLLLGV 595
Query: 778 ERLSRLASG 804
+RL L G
Sbjct: 596 KRLLDLQKG 604
>sp|Q8VHK2|CSKI1_RAT Caskin-1 (CASK interacting protein 1)
Length = 1430
Score = 111 bits (277), Expect = 3e-24
Identities = 55/141 (39%), Positives = 88/141 (62%)
Frame = +1
Query: 373 STTGSDRGVDDIMVNWLSFVGLGNYSDVLSNAGYDLATLAKATPEDLNASGVTNPKDRQL 552
S++ S+ + + WL+ L Y+ ++AGYDL T+++ TPEDL A GVT P R+
Sbjct: 467 SSSASEGKSAEAVSQWLATFQLQLYAPNFTSAGYDLPTISRMTPEDLTAIGVTKPGHRKK 526
Query: 553 MKTHLNRLSVCDGLPETMPVSIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADI 732
+ ++ L++ D LPE P ++ +L + L QY ++LV + I+ + +TWEDL +I
Sbjct: 527 ITAEISGLNIPDCLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEI 586
Query: 733 GVEKLGHQKKLSLAIERLSRL 795
G+ KLGHQKKL LA+ +L+ L
Sbjct: 587 GITKLGHQKKLMLAVRKLAEL 607
>sp|Q6P9K8|CSKI1_MOUSE Caskin-1 (CASK-interacting protein 1)
Length = 1431
Score = 111 bits (277), Expect = 3e-24
Identities = 55/141 (39%), Positives = 87/141 (61%)
Frame = +1
Query: 373 STTGSDRGVDDIMVNWLSFVGLGNYSDVLSNAGYDLATLAKATPEDLNASGVTNPKDRQL 552
S + S+ + + WL+ L Y+ ++AGYDL T+++ TPEDL A GVT P R+
Sbjct: 469 SASASEGKSAEAVSQWLATFQLQLYAPNFTSAGYDLPTISRMTPEDLTAIGVTKPGHRKK 528
Query: 553 MKTHLNRLSVCDGLPETMPVSIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADI 732
+ ++ L++ D LPE P ++ +L + L QY ++LV + I+ + +TWEDL +I
Sbjct: 529 ITAEISGLNIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEI 588
Query: 733 GVEKLGHQKKLSLAIERLSRL 795
G+ KLGHQKKL LA+ +L+ L
Sbjct: 589 GITKLGHQKKLMLAVRKLAEL 609
>sp|Q8VHK1|CSKI2_MOUSE Caskin-2
Length = 1201
Score = 110 bits (276), Expect = 4e-24
Identities = 56/131 (42%), Positives = 82/131 (62%)
Frame = +1
Query: 415 NWLSFVGLGNYSDVLSNAGYDLATLAKATPEDLNASGVTNPKDRQLMKTHLNRLSVCDGL 594
NWLS L Y+ AGYD+ T+++ TPEDL A GVT P R+ + + + +LS+ + L
Sbjct: 495 NWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWL 554
Query: 595 PETMPVSIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADIGVEKLGHQKKLSLA 774
P +PV + ++L L L QY + LV + + + LTWE+L +IGV KLGHQKKL L
Sbjct: 555 PNYIPVDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLG 614
Query: 775 IERLSRLASGV 807
++RL+ L G+
Sbjct: 615 VKRLAELRRGL 625
>sp|Q8WXD9|CSKI1_HUMAN Caskin-1 (CASK interacting protein 1)
Length = 1431
Score = 110 bits (274), Expect = 7e-24
Identities = 54/126 (42%), Positives = 80/126 (63%)
Frame = +1
Query: 418 WLSFVGLGNYSDVLSNAGYDLATLAKATPEDLNASGVTNPKDRQLMKTHLNRLSVCDGLP 597
WL+ L Y+ +AGYDL T+++ TPEDL A GVT P R+ + ++ LS+ D LP
Sbjct: 480 WLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLP 539
Query: 598 ETMPVSIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADIGVEKLGHQKKLSLAI 777
E P ++ +L + L QY ++LV + I+ + +TWEDL +IG+ KLGHQKKL LA+
Sbjct: 540 EHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAV 599
Query: 778 ERLSRL 795
+L+ L
Sbjct: 600 RKLAEL 605
>sp|Q8WXE0|CSKI2_HUMAN Caskin-2
Length = 1202
Score = 109 bits (272), Expect = 1e-23
Identities = 55/131 (41%), Positives = 81/131 (61%)
Frame = +1
Query: 415 NWLSFVGLGNYSDVLSNAGYDLATLAKATPEDLNASGVTNPKDRQLMKTHLNRLSVCDGL 594
NWLS L Y+ AGYD+ T+++ TPEDL A GVT P R+ + + + +LS+ + L
Sbjct: 496 NWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWL 555
Query: 595 PETMPVSIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADIGVEKLGHQKKLSLA 774
P +P + ++L L L QY + LV + + + LTWE+L +IGV KLGHQKKL L
Sbjct: 556 PSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLG 615
Query: 775 IERLSRLASGV 807
++RL+ L G+
Sbjct: 616 VKRLAELRRGL 626
>sp|P54755|EPHA5_CHICK Ephrin type-A receptor 5 precursor (Tyrosine-protein kinase receptor
CEK7)
Length = 1013
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/102 (29%), Positives = 59/102 (57%), Gaps = 8/102 (7%)
Frame = +1
Query: 526 VTNPKDRQLMKTHLNRLS-VCDGLPETMPV------SIHDFLDNLKLLQYEELLVKQNFS 684
+ NP +KT +N S V + L E PV S+ ++L+ +K+ +Y E+ ++ +S
Sbjct: 912 IRNPSS---LKTLVNASSRVSNLLVEHSPVGSGAYRSVGEWLEAIKMGRYTEIFMENGYS 968
Query: 685 KIEHLVGLTWEDLADIGVEKLGHQKKLSLAIERLS-RLASGV 807
++ + +T EDL +GV +GHQKK+ +++ + +L +G+
Sbjct: 969 SMDSVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGM 1010
Score = 35.8 bits (81), Expect = 0.17
Identities = 34/139 (24%), Positives = 59/139 (42%), Gaps = 6/139 (4%)
Frame = +1
Query: 184 PPTMPAPFHQC-----SEDNSIRQNFYQNISNVDNDFGLPRTNSYSQQVSIDSLYYPCSM 348
P PA +Q +D + R F + +S +D P S+ +L S
Sbjct: 876 PMDCPAALYQLMLDCWQKDRNSRPKFDEIVSMLDKLIRNPS--------SLKTLVNASSR 927
Query: 349 ISLDETQYSTTGSDRGVDDIMVNWLSFVGLGNYSDVLSNAGY-DLATLAKATPEDLNASG 525
+S ++S GS G + WL + +G Y+++ GY + ++A+ T EDL G
Sbjct: 928 VSNLLVEHSPVGS--GAYRSVGEWLEAIKMGRYTEIFMENGYSSMDSVAQVTLEDLRRLG 985
Query: 526 VTNPKDRQLMKTHLNRLSV 582
VT ++ + L + V
Sbjct: 986 VTLVGHQKKIMNSLQEMKV 1004
>sp|P59672|ANKS1_MOUSE Ankyrin repeat and SAM domain-containing protein 1
Length = 1150
Score = 45.1 bits (105), Expect = 3e-04
Identities = 36/145 (24%), Positives = 64/145 (44%), Gaps = 6/145 (4%)
Frame = +1
Query: 349 ISLDETQYSTTGSDRGVDDIMVNWLSFVGLGNYSDVLSNAGYDLATLAKAT---PEDLNA 519
I + Q +GS R ++ + WL +GL Y L G+D + +DL
Sbjct: 698 IDFSQEQQKISGS-RTLEQSVGEWLESIGLQQYESKLLLNGFDDVRFLGSNVMEEQDLRE 756
Query: 520 SGVTNPKDRQLMKTHLNRLSVCD--GLPETMPVSIHDFLDNLKLLQYEELLVKQNFSKIE 693
G+++P+ R+ + L G P S+ +LD+L L Y + +S I+
Sbjct: 757 IGISDPQHRRKLLQAARSLPKVKALGYDGVSPTSVPSWLDSLGLQDYVHSFLSSGYSSID 816
Query: 694 HLVGLTWEDLADI-GVEKLGHQKKL 765
+ L +L ++ V LGH+K++
Sbjct: 817 TVKNLWELELVNVLKVHLLGHRKRI 841
Score = 34.3 bits (77), Expect = 0.48
Identities = 20/67 (29%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Frame = +1
Query: 601 TMPVSIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWE--DLADIGVEKLGHQKKLSLA 774
T+ S+ ++L+++ L QYE L+ F + L E DL +IG+ H++KL A
Sbjct: 712 TLEQSVGEWLESIGLQQYESKLLLNGFDDVRFLGSNVMEEQDLREIGISDPQHRRKLLQA 771
Query: 775 IERLSRL 795
L ++
Sbjct: 772 ARSLPKV 778
>sp|P54753|EPHB3_HUMAN Ephrin type-B receptor 3 precursor (Tyrosine-protein kinase receptor
HEK-2)
Length = 998
Score = 43.9 bits (102), Expect = 6e-04
Identities = 21/56 (37%), Positives = 35/56 (62%)
Frame = +1
Query: 613 SIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADIGVEKLGHQKKLSLAIE 780
++ D+LD +K+ +Y+E V F+ + + +T EDL IGV GHQKK+ +I+
Sbjct: 929 TVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQ 984
Score = 33.1 bits (74), Expect = 1.1
Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 9/155 (5%)
Frame = +1
Query: 181 LPPTMPAP--FHQCSEDNSIR-QNFYQNISNVDNDFGLPRTNSYSQQVSIDSLYYPCSMI 351
LPP M P HQ D +R +N S + N N+ S +V I S S
Sbjct: 857 LPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKV-IASAQSGMSQP 915
Query: 352 SLDET-----QYSTTGSDRGVDDIMVNWLSFVGLGNYSDVLSNAGY-DLATLAKATPEDL 513
LD T ++T G +WL + +G Y + +AG+ +A+ T EDL
Sbjct: 916 LLDRTVPDYTTFTTVG----------DWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDL 965
Query: 514 NASGVTNPKDRQLMKTHLNRLSVCDGLPETMPVSI 618
GVT ++ + + + + + + +T+PV +
Sbjct: 966 LRIGVTLAGHQKKILSSIQDMRL--QMNQTLPVQV 998
>sp|P54754|EPHB3_MOUSE Ephrin type-B receptor 3 precursor (Tyrosine-protein kinase receptor
MDK-5) (Developmental kinase 5) (SEK-4)
Length = 993
Score = 43.5 bits (101), Expect = 8e-04
Identities = 21/56 (37%), Positives = 35/56 (62%)
Frame = +1
Query: 613 SIHDFLDNLKLLQYEELLVKQNFSKIEHLVGLTWEDLADIGVEKLGHQKKLSLAIE 780
++ D+LD +K+ +Y+E V F+ + + +T EDL IGV GHQKK+ +I+
Sbjct: 924 TVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILCSIQ 979
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.314 0.129 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,579,381
Number of Sequences: 369166
Number of extensions: 2157541
Number of successful extensions: 4578
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4340
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4566
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8982382310
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)