Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_02018
(821 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P08510|KCNAS_DROME Potassium voltage-gated channel prote... 62 1e-09
sp|P63142|KCNA2_RAT Potassium voltage-gated channel subfami... 62 2e-09
sp|P16389|KCNA2_HUMAN Potassium voltage-gated channel subfa... 62 2e-09
sp|Q28293|KCNA2_CANFA Potassium voltage-gated channel subfa... 62 2e-09
sp|P22739|KCNA2_XENLA Potassium voltage-gated channel subfa... 62 2e-09
sp|Q14721|KCB1_HUMAN Potassium voltage-gated channel subfam... 61 3e-09
sp|O18868|KCNB1_PIG Potassium voltage-gated channel subfami... 61 3e-09
sp|Q9MZ19|KCNB1_RABIT Potassium voltage-gated channel subfa... 61 3e-09
sp|P15387|KCNB1_RAT Potassium voltage-gated channel subfami... 61 3e-09
sp|Q03717|KCNB1_MOUSE Potassium voltage-gated channel subfa... 61 3e-09
>sp|P08510|KCNAS_DROME Potassium voltage-gated channel protein Shaker
Length = 656
Score = 62.4 bits (150), Expect = 1e-09
Identities = 27/55 (49%), Positives = 34/55 (61%)
Frame = +2
Query: 656 SEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
S FKSI D WWA TM +VGYGD P +G IVG C + G++ LPVP+ +
Sbjct: 424 SFFKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIV 478
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/61 (31%), Positives = 35/61 (57%)
Frame = +3
Query: 459 ILKVPRFFRIFRLSKHLRFGMDAFILTLRGSTAEMLLVLIISIVAICFFGVAIYVVELSN 638
++++ R FRIF+LS+H + G+ TL+ S E+ L++ + + F A+Y E +
Sbjct: 363 VIRLVRVFRIFKLSRHSK-GLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGS 421
Query: 639 E 641
E
Sbjct: 422 E 422
>sp|P63142|KCNA2_RAT Potassium voltage-gated channel subfamily A member 2 (Voltage-gated
potassium channel subunit Kv1.2) (RBK2) (RCK5) (RAK)
sp|P63141|KCNA2_MOUSE Potassium voltage-gated channel subfamily A member 2 (Voltage-gated
potassium channel subunit Kv1.2) (MK2)
Length = 499
Score = 61.6 bits (148), Expect = 2e-09
Identities = 27/57 (47%), Positives = 36/57 (63%)
Frame = +2
Query: 650 RFSEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
R S+F SI D WWA +M +VGYGD VP + G IVG C + G++ LPVP+ +
Sbjct: 354 RDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIV 410
Score = 42.0 bits (97), Expect = 0.002
Identities = 53/220 (24%), Positives = 87/220 (39%), Gaps = 12/220 (5%)
Frame = +3
Query: 6 PPKEFGKQSYYNRAQTACNLIALSETSGLFSRWYTLIYGMGLVISIVNLIFSTTRLGR-- 179
P EF +Q + L E+SG +R ++ M ++ISIV+ T + R
Sbjct: 141 PENEFQRQVWL--------LFEYPESSGP-ARIIAIVSVMVILISIVSFCLETLPIFRDE 191
Query: 180 -VDKITKKISKYYTGESIISYFKRTVPTPXXXXXXXXXXXXXXXXXXXXXXXXPEKILFW 356
D ++ + S I Y + T T P K F+
Sbjct: 192 NEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFF 251
Query: 357 VDFLNWTDILVIT------SSVLSYLPMIKDIGEYEIYPIILKVPRF---FRIFRLSKHL 509
+ +N DI+ I + L+ P G+ + IL+V R FRIF+LS+H
Sbjct: 252 TNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHS 311
Query: 510 RFGMDAFILTLRGSTAEMLLVLIISIVAICFFGVAIYVVE 629
+ G+ TL+ S E+ L++ + + F A+Y E
Sbjct: 312 K-GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE 350
>sp|P16389|KCNA2_HUMAN Potassium voltage-gated channel subfamily A member 2 (Voltage-gated
potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV)
Length = 499
Score = 61.6 bits (148), Expect = 2e-09
Identities = 27/57 (47%), Positives = 36/57 (63%)
Frame = +2
Query: 650 RFSEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
R S+F SI D WWA +M +VGYGD VP + G IVG C + G++ LPVP+ +
Sbjct: 354 RESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIV 410
Score = 43.1 bits (100), Expect = 0.001
Identities = 54/227 (23%), Positives = 88/227 (38%), Gaps = 12/227 (5%)
Frame = +3
Query: 6 PPKEFGKQSYYNRAQTACNLIALSETSGLFSRWYTLIYGMGLVISIVNLIFSTTRLGR-- 179
P EF +Q + L E+SG +R ++ M ++ISIV+ T + R
Sbjct: 141 PENEFQRQVWL--------LFEYPESSGP-ARIIAIVSVMVILISIVSFCLETLPIFRDE 191
Query: 180 -VDKITKKISKYYTGESIISYFKRTVPTPXXXXXXXXXXXXXXXXXXXXXXXXPEKILFW 356
D ++ + S I Y + T T P K F+
Sbjct: 192 NEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFF 251
Query: 357 VDFLNWTDILVIT------SSVLSYLPMIKDIGEYEIYPIILKVPRF---FRIFRLSKHL 509
+ +N DI+ I + L+ P G+ + IL+V R FRIF+LS+H
Sbjct: 252 TNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHS 311
Query: 510 RFGMDAFILTLRGSTAEMLLVLIISIVAICFFGVAIYVVELSNEMPQ 650
+ G+ TL+ S E+ L++ + + F A+Y E Q
Sbjct: 312 K-GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQ 357
>sp|Q28293|KCNA2_CANFA Potassium voltage-gated channel subfamily A member 2 (Voltage-gated
potassium channel subunit Kv1.2) (CSMK1)
Length = 499
Score = 61.6 bits (148), Expect = 2e-09
Identities = 27/57 (47%), Positives = 36/57 (63%)
Frame = +2
Query: 650 RFSEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
R S+F SI D WWA +M +VGYGD VP + G IVG C + G++ LPVP+ +
Sbjct: 354 RESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIV 410
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/227 (23%), Positives = 88/227 (38%), Gaps = 12/227 (5%)
Frame = +3
Query: 6 PPKEFGKQSYYNRAQTACNLIALSETSGLFSRWYTLIYGMGLVISIVNLIFSTTRLGR-- 179
P EF +Q + L E+SG +R ++ M ++ISIV+ T + R
Sbjct: 141 PENEFQRQVWL--------LFEYPESSGP-ARIIAIVSVMVILISIVSFCLETLPIFRDE 191
Query: 180 -VDKITKKISKYYTGESIISYFKRTVPTPXXXXXXXXXXXXXXXXXXXXXXXXPEKILFW 356
D ++ + S I Y + T T P K F+
Sbjct: 192 NEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFF 251
Query: 357 VDFLNWTDILVIT------SSVLSYLPMIKDIGEYEIYPIILKVPRF---FRIFRLSKHL 509
+ +N DI+ I + L+ P G+ + IL+V R FRIF+LS+H
Sbjct: 252 TNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHS 311
Query: 510 RFGMDAFILTLRGSTAEMLLVLIISIVAICFFGVAIYVVELSNEMPQ 650
+ G+ TL+ S E+ L++ + + F A+Y E Q
Sbjct: 312 K-GLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQ 357
>sp|P22739|KCNA2_XENLA Potassium voltage-gated channel subfamily A member 2 (Voltage-gated
potassium channel subunit Kv1.2) (xSHA2)
Length = 499
Score = 61.6 bits (148), Expect = 2e-09
Identities = 27/57 (47%), Positives = 36/57 (63%)
Frame = +2
Query: 650 RFSEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
R S+F SI D WWA +M +VGYGD VP + G IVG C + G++ LPVP+ +
Sbjct: 354 RDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIV 410
Score = 38.1 bits (87), Expect = 0.029
Identities = 28/107 (26%), Positives = 51/107 (47%), Gaps = 9/107 (8%)
Frame = +3
Query: 336 PEKILFWVDFLNWTDILVITSSVLSYLPMIKDI------GEYEIYPIILKVPRF---FRI 488
P K +F+ + +N DI+ I ++ + + G+ + IL+V R FRI
Sbjct: 245 PSKAVFFTNLMNIIDIVAIIPYFITLGTELAEKTEDGQQGQQAMSLAILRVIRLVRVFRI 304
Query: 489 FRLSKHLRFGMDAFILTLRGSTAEMLLVLIISIVAICFFGVAIYVVE 629
F+LS+H + G+ TL S E+ L++ + + F A++ E
Sbjct: 305 FKLSRHSK-GLQILGQTLNASMRELGLLIFFLFIGVILFSSAVFFAE 350
>sp|Q14721|KCB1_HUMAN Potassium voltage-gated channel subfamily B member 1 (Voltage-gated
potassium channel subunit Kv2.1) (h-DRK1)
Length = 858
Score = 61.2 bits (147), Expect = 3e-09
Identities = 25/55 (45%), Positives = 36/55 (65%)
Frame = +2
Query: 656 SEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
++FKSI WWA TM +VGYGD P++ G IVG C + G+++ LP+PI +
Sbjct: 359 TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413
>sp|O18868|KCNB1_PIG Potassium voltage-gated channel subfamily B member 1 (Voltage-gated
potassium channel subunit Kv2.1) (DRK1)
Length = 858
Score = 61.2 bits (147), Expect = 3e-09
Identities = 25/55 (45%), Positives = 36/55 (65%)
Frame = +2
Query: 656 SEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
++FKSI WWA TM +VGYGD P++ G IVG C + G+++ LP+PI +
Sbjct: 359 TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413
>sp|Q9MZ19|KCNB1_RABIT Potassium voltage-gated channel subfamily B member 1 (Voltage-gated
potassium channel subunit Kv2.1)
Length = 858
Score = 61.2 bits (147), Expect = 3e-09
Identities = 25/55 (45%), Positives = 36/55 (65%)
Frame = +2
Query: 656 SEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
++FKSI WWA TM +VGYGD P++ G IVG C + G+++ LP+PI +
Sbjct: 359 TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413
>sp|P15387|KCNB1_RAT Potassium voltage-gated channel subfamily B member 1 (Voltage-gated
potassium channel subunit Kv2.1) (DRK1)
Length = 857
Score = 61.2 bits (147), Expect = 3e-09
Identities = 25/55 (45%), Positives = 36/55 (65%)
Frame = +2
Query: 656 SEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
++FKSI WWA TM +VGYGD P++ G IVG C + G+++ LP+PI +
Sbjct: 359 TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413
>sp|Q03717|KCNB1_MOUSE Potassium voltage-gated channel subfamily B member 1 (Voltage-gated
potassium channel subunit Kv2.1) (mShab)
Length = 857
Score = 61.2 bits (147), Expect = 3e-09
Identities = 25/55 (45%), Positives = 36/55 (65%)
Frame = +2
Query: 656 SEFKSIFDGMWWAASTMASVGYGDYVPRSTYGCIVGYFCILTGIIITQLPVPIFL 820
++FKSI WWA TM +VGYGD P++ G IVG C + G+++ LP+PI +
Sbjct: 359 TKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIV 413
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,743,766
Number of Sequences: 369166
Number of extensions: 1744066
Number of successful extensions: 4230
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4055
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4224
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)