Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01969
(772 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NFU0|FXR1_DROME Fragile X mental retardation syndrome-... 111 2e-24
sp|P51113|FMR1_XENLA Fragile X mental retardation protein 1... 105 1e-22
sp|Q61584|FXR1_MOUSE Fragile X mental retardation syndrome-... 94 3e-19
sp|P51115|FXR1_XENLA Fragile X mental retardation syndrome-... 89 2e-17
sp|P51114|FXR1_HUMAN Fragile X mental retardation syndrome-... 88 2e-17
sp|O70523|FXR1_CRIGR Fragile X mental retardation syndrome-... 87 4e-17
sp|P35922|FMR1_MOUSE Fragile X mental retardation protein 1... 87 7e-17
sp|Q06787|FMR1_HUMAN Fragile X mental retardation 1 protein... 82 2e-15
sp|P51116|FXR2_HUMAN Fragile X mental retardation syndrome-... 80 5e-15
sp|Q9WVR4|FXR2_MOUSE Fragile X mental retardation syndrome-... 77 4e-14
>sp|Q9NFU0|FXR1_DROME Fragile X mental retardation syndrome-related protein 1 (dFMR1)
(dfxr)
Length = 684
Score = 111 bits (277), Expect = 2e-24
Identities = 89/287 (31%), Positives = 141/287 (49%), Gaps = 37/287 (12%)
Frame = +3
Query: 3 IINIDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIID 182
+ NI+L++++ TF IS LEY ++ F VP ++V KVIG++G IQ+I+D
Sbjct: 253 VTNIELEEKSCTFKISGETEESVQRARAMLEYAEEFFQVpreLVGKVIGKNGRIIQEIVD 312
Query: 183 QSGVMRVRV--VEGPDLSNWKDEENKHLLEDHVPFIFVGSSNSIRDACLLLEFSIDHHRE 356
+SGV R++V + G D + ++N HVPF+F+G+ SI +A +LLE+ + H +E
Sbjct: 313 KSGVFRIKVSAIAGDD----EQDQNIpreLAHVPFVFIGTVESIANAKVLLEYHLSHLKE 368
Query: 357 MDRLQKERDEIHREIR---NNKAASNTNFKYANHSASEKEEDHFIPQNRPF-----NSRG 512
+++L++E+ EI +++R + S +F S D I R RG
Sbjct: 369 VEQLRQEKMEIDQQLRAIQESSMGSTQSFPVTRRSERGYSSD--IESVRSMRGGGGGQRG 426
Query: 513 RNRGR---------GMFKNVSNSDVERNDNYAEDTNYRNNQR----------NGSYRRGI 635
R RGR G+ + N+ + +D + + R+ QR GSYR G
Sbjct: 427 RVRGRGGGGPGGGNGLNQRYHNNRRDEDDYNSRGDHQRDQQRGYNDRGGGDNTGSYRGGG 486
Query: 636 GNF-----NRQGSL---PPTSINGQHNGARRYQGEDDTDDYASATNE 752
G NR+G + PP N Q NG R YQ + T + T E
Sbjct: 487 GGAGGPGNNRRGGINRRPPR--NDQQNG-RDYQHHNHTTEEVRETRE 530
>sp|P51113|FMR1_XENLA Fragile X mental retardation protein 1 homolog (Protein FMR-1)
(FMRP)
Length = 564
Score = 105 bits (262), Expect = 1e-22
Identities = 80/263 (30%), Positives = 133/263 (50%), Gaps = 11/263 (4%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
IDLD+ T TF I LE+ + + VP ++V KVIG++G IQ+I+D+SG
Sbjct: 253 IDLDEDTCTFHIYGEDQEAVKKARTYLEFAENVIQVPRNLVGKVIGKNGKLIQEIVDKSG 312
Query: 192 VMRVRVVEGPDLSNWKDEENKHLLEDHVPFIFVGSSNSIRDACLLLEFSIDHHREMDRLQ 371
V+RVR+ ++++N E VPF+FVG+ +SI +A +LL++ +++ +E+D+L+
Sbjct: 313 VVRVRI-------EAENDKNISQEEGIVPFVFVGTKDSITNATVLLDYHLNYLKEVDQLR 365
Query: 372 KERDEIHREIRNNKAASNTNFKYANHSASEKEED--HFIPQNRPFNSRGRNR-----GRG 530
ER +I ++R+ A+S + ED + +RP+++RGR+R G
Sbjct: 366 LERLQIDEQLRHIGASSRPPPNRPDKEKGYLSEDCSGTVRGSRPYSNRGRSRRGTGYASG 425
Query: 531 MFKNVSNSDVERNDNYAEDTNY----RNNQRNGSYRRGIGNFNRQGSLPPTSINGQHNGA 698
SN+ +D+ E +++ + R+ +RRG G R+G GQ G
Sbjct: 426 TNSEASNASETESDHRDELSDWSLAPAEDDRDNYHRRGDG--RRRG-----GTRGQ--GM 476
Query: 699 RRYQGEDDTDDYASATNESENGR 767
R G DD N N R
Sbjct: 477 RGRGGFKGNDDQPRPDNRQRNSR 499
>sp|Q61584|FXR1_MOUSE Fragile X mental retardation syndrome-related protein 1
Length = 677
Score = 94.4 bits (233), Expect = 3e-19
Identities = 73/228 (32%), Positives = 116/228 (50%), Gaps = 21/228 (9%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
I+LD+ T TF I LE+++ VP ++V KVIG++G IQ+I+D+SG
Sbjct: 253 IELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSG 312
Query: 192 VMRVRVVEGPDLSNWKDEENKHLLED-HVPFIFVGSSNSIRDACLLLEFSIDHHREMDRL 368
V+RVR +EG D ENK ED VPF+FVG+ SI + +LLE+ I + +E+++L
Sbjct: 313 VVRVR-IEG-------DNENKLpreDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQL 364
Query: 369 QKERDEIHREIR----NNKAASNTNFKYANHSASEKEEDHFIPQNRPFNSRGRNR----- 521
+ ER +I ++R + +S + A+++ + +R ++ RGR R
Sbjct: 365 RMERLQIDEQLRQIGMGFRPSSTRGPEREKGYATDESTVSSVQGSRSYSGRGRGRRGPNY 424
Query: 522 --GRGM---FKNVSNSDVERNDNYA------EDTNYRNNQRNGSYRRG 632
G G N S ++ ER D + ED +QR+ R G
Sbjct: 425 TSGYGTNSELSNPSETESERKDELSDWSLAGEDDRETRHQRDSRRRPG 472
>sp|P51115|FXR1_XENLA Fragile X mental retardation syndrome-related protein 1
Length = 648
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/242 (29%), Positives = 121/242 (50%), Gaps = 23/242 (9%)
Frame = +3
Query: 3 IINIDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIID 182
I I+LD+ + TF I LE+++ VP ++V KVIG++G IQ+I+D
Sbjct: 250 ITAIELDEDSGTFRIYGESAEAVKKARSYLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVD 309
Query: 183 QSGVMRVRVVEGPDLSNWKDEENKHLLED-HVPFIFVGSSNSIRDACLLLEFSIDHHREM 359
+S V+RVR +EG D E K ED VPF+FVG+ +I + +LLE+ I + +E+
Sbjct: 310 KSRVVRVR-IEG-------DNETKLpreDGMVPFVFVGTKENIGNVQVLLEYHIAYLKEV 361
Query: 360 DRLQKERDEIHREIRNNKAASNTNFKYANHSASEKEEDHFIPQ--------NRPFNSRGR 515
++L+ ER +I ++R F+ ++ +EKE+ + + +R ++ RGR
Sbjct: 362 EQLRMERLQIDEQLRQ----IGMGFRPSSSRGTEKEKGYATDESTASSVRGSRSYSGRGR 417
Query: 516 NR-------GRGM---FKNVSNSDVERNDNYAE----DTNYRNNQRNGSYRRGIGNFNRQ 653
R G G N S ++ ER + ++ + R +++ RR G R
Sbjct: 418 GRRGPNYTSGYGTNSELSNPSETESERKEELSDWSLAGEDERESRQQRDSRRRPGGRGRS 477
Query: 654 GS 659
GS
Sbjct: 478 GS 479
>sp|P51114|FXR1_HUMAN Fragile X mental retardation syndrome-related protein 1
Length = 621
Score = 88.2 bits (217), Expect = 2e-17
Identities = 60/170 (35%), Positives = 92/170 (54%), Gaps = 18/170 (10%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
I+LD+ T TF I LE+++ VP ++V KVIG++G IQ+I+D+SG
Sbjct: 253 IELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSG 312
Query: 192 VMRVRVVEGPDLSNWKDEENKHLLED-HVPFIFVGSSNSIRDACLLLEFSIDHHREMDRL 368
V+RVR +EG D ENK ED VPF+FVG+ SI + +LLE+ I + +E+++L
Sbjct: 313 VVRVR-IEG-------DNENKLpreDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQL 364
Query: 369 QKERDEIHREIR-----------------NNKAASNTNFKYANHSASEKE 467
+ ER +I ++R N + TN + +N S +E E
Sbjct: 365 RMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESE 414
>sp|O70523|FXR1_CRIGR Fragile X mental retardation syndrome-related protein 1
Length = 621
Score = 87.4 bits (215), Expect = 4e-17
Identities = 59/170 (34%), Positives = 92/170 (54%), Gaps = 18/170 (10%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
I+LD+ T TF I +E+++ VP ++V KVIG++G IQ+I+D+SG
Sbjct: 253 IELDEDTGTFRIYGESAEAVKKARGFMEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSG 312
Query: 192 VMRVRVVEGPDLSNWKDEENKHLLED-HVPFIFVGSSNSIRDACLLLEFSIDHHREMDRL 368
V+RVR +EG D ENK ED VPF+FVG+ SI + +LLE+ I + +E+++L
Sbjct: 313 VVRVR-IEG-------DNENKLpreDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQL 364
Query: 369 QKERDEIHREIR-----------------NNKAASNTNFKYANHSASEKE 467
+ ER +I ++R N + TN + +N S +E E
Sbjct: 365 RMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESE 414
>sp|P35922|FMR1_MOUSE Fragile X mental retardation protein 1 homolog (Protein FMR-1) (FMRP)
Length = 614
Score = 86.7 bits (213), Expect = 7e-17
Identities = 84/326 (25%), Positives = 136/326 (41%), Gaps = 74/326 (22%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
IDLD+ T TF I LE+ + + VP ++V KVIG++G IQ+I+D+SG
Sbjct: 253 IDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSG 312
Query: 192 VMRVRVVE-------------------------GPDLSNWKD----EENKHLLEDH---- 272
V+RVR+ GP+ S K +EN H + +
Sbjct: 313 VVRVRIEAENEKSVPQEEEIMPPSSLPSNNSRVGPNSSEEKKHLDTKENTHFSQPNSTKV 372
Query: 273 -------------------------VPFIFVGSSNSIRDACLLLEFSIDHHREMDRLQKE 377
VPF+FVG+ +SI +A +LL++ +++ +E+D+L+ E
Sbjct: 373 QRVLVVSSIVAGGPQKPEPKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLE 432
Query: 378 RDEIHREIRNNKAASNTNFKYANHSASEKEEDHFIPQ-------NRPFNSRGRNR----- 521
R +I ++R A+S + ++KE+ + +RP+ +RG R
Sbjct: 433 RLQIDEQLRQIGASSR-----PPPNRTDKEKGYVTDDGQGMGRGSRPYRNRGHGRRGPGY 487
Query: 522 GRGMFKNVSNSDVERNDNYAEDTNY----RNNQRNGSYRRGIGNFNRQGSLPPTSINGQH 689
G SN+ +D+ E +++ +R RRG G R G GQ
Sbjct: 488 TSGTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDGRRRRGGG------RGQ- 540
Query: 690 NGARRYQGEDDTDDYASATNESENGR 767
G R G DD++ N N R
Sbjct: 541 GGRGRGGGFKGNDDHSRTDNRPRNPR 566
>sp|Q06787|FMR1_HUMAN Fragile X mental retardation 1 protein (Protein FMR-1) (FMRP)
Length = 632
Score = 82.0 bits (201), Expect = 2e-15
Identities = 84/324 (25%), Positives = 133/324 (41%), Gaps = 72/324 (22%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
IDLD+ T TF I LE+ + + VP ++V KVIG++G IQ+I+D+SG
Sbjct: 253 IDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSG 312
Query: 192 VMRVRVVEGPDLSNWKDE----------------------ENKHL--------------- 260
V+RVR +E + N E E KHL
Sbjct: 313 VVRVR-IEAENEKNVPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNST 371
Query: 261 -----------------------LEDHVPFIFVGSSNSIRDACLLLEFSIDHHREMDRLQ 371
+ VPF+FVG+ +SI +A +LL++ +++ +E+D+L+
Sbjct: 372 KVQRVLVASSVVAGESQKPELKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLR 431
Query: 372 KERDEIHREIRNNKAASNTNFKYANHSASEKEED--HFIPQNRPFNSRGRNR-----GRG 530
ER +I ++R A+S + S +D +RP+ +RG R G
Sbjct: 432 LERLQIDEQLRQIGASSRPPPNRTDKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSG 491
Query: 531 MFKNVSNSDVERNDNYAEDTNY----RNNQRNGSYRRGIGNFNRQGSLPPTSINGQHNGA 698
SN+ +D+ E +++ +R RRG G R+G G+ G
Sbjct: 492 TNSEASNASETESDHRDELSDWSLAPTEEERESFLRRGDG--RRRGG------GGRGQGG 543
Query: 699 R-RYQGEDDTDDYASATNESENGR 767
R R G DD++ N N R
Sbjct: 544 RGRGGGFKGNDDHSRTDNRPRNPR 567
>sp|P51116|FXR2_HUMAN Fragile X mental retardation syndrome-related protein 2
Length = 673
Score = 80.5 bits (197), Expect = 5e-15
Identities = 48/131 (36%), Positives = 76/131 (58%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
I+L + T TF I LE+ + VP ++V KVIG++G IQ+I+D+SG
Sbjct: 263 IELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSG 322
Query: 192 VMRVRVVEGPDLSNWKDEENKHLLEDHVPFIFVGSSNSIRDACLLLEFSIDHHREMDRLQ 371
V+RVRV D N ++ E VPFIFVG+ +I +A LLE+ + + +E+++L+
Sbjct: 323 VVRVRVEGDNDKKNpre-------EGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLR 375
Query: 372 KERDEIHREIR 404
ER +I ++R
Sbjct: 376 LERLQIDEQLR 386
>sp|Q9WVR4|FXR2_MOUSE Fragile X mental retardation syndrome-related protein 2
Length = 673
Score = 77.4 bits (189), Expect = 4e-14
Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 10/220 (4%)
Frame = +3
Query: 12 IDLDDRTHTFTISXXXXXXXXXXXXXLEYLKKIFYVPMDIVSKVIGRSGNQIQDIIDQSG 191
I+L + T TF I LE+ + VP D+V KV G++G IQ I+D+SG
Sbjct: 263 IELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRDLVGKVTGKTGKVIQGIVDKSG 322
Query: 192 VMRVRVVEGPDLSNWKDEENKHLLEDHVPFIFVGSSNSIRDACLLLEFSIDHHREMDRLQ 371
V+RVRV D N K+ VPFIFVG+ +I +A LLE+ + + +E++ L+
Sbjct: 323 VVRVRVEGDNDKKNPKE-------GGMVPFIFVGTRENISNAQALLEYHLSYLQEVETLR 375
Query: 372 KERDEIHREIR----------NNKAASNTNFKYANHSASEKEEDHFIPQNRPFNSRGRNR 521
ER +I ++R + + S A ++ E + R + R
Sbjct: 376 LERLQIDEQLRQIGAGFRPPGSGRGGSGGGSDKAGYTTDESSSSS-LHTTRTYGGSYGGR 434
Query: 522 GRGMFKNVSNSDVERNDNYAEDTNYRNNQRNGSYRRGIGN 641
GRG + + A +T + +R S R G G+
Sbjct: 435 GRGRRTGGPAYGPSSDPSTASET--ESEKREESNRAGPGD 472
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,661,763
Number of Sequences: 369166
Number of extensions: 1906633
Number of successful extensions: 6665
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5808
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6302
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)