Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01904
(790 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 127 3e-29
sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 (... 121 2e-27
sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (... 121 2e-27
sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2 120 3e-27
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 120 4e-27
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 120 4e-27
sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p... 119 7e-27
sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 ... 119 7e-27
sp|Q61036|PAK3_MOUSE Serine/threonine-protein kinase PAK 3 ... 119 7e-27
sp|Q13188|STK3_HUMAN Serine/threonine-protein kinase 3 (STE... 118 2e-26
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 127 bits (320), Expect = 3e-29
Identities = 67/160 (41%), Positives = 95/160 (59%)
Frame = +1
Query: 166 YSKQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQ 345
Y+KQ+L L+YLH I+HRDIK NIL+D ++L DFG SK + +LA +NG K
Sbjct: 176 YTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELAT---VNGAK- 231
Query: 346 SSVGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKI 525
S GT +MAPE++ + FSAD+WS G T++EM TG PP+ + L K
Sbjct: 232 SMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKA 291
Query: 526 EYNYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFLS 645
P DLS K F+ CLH +P+ RL++ + + HPF++
Sbjct: 292 HPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFVT 331
>sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
(Serine/threonine-protein kinase MASK) (Mst3 and
SOK1-related kinase)
Length = 416
Score = 121 bits (304), Expect = 2e-27
Identities = 61/157 (38%), Positives = 95/157 (60%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
K+IL+ L YLH +K +HRDIK+ N+LL E +VKL DFG++ LTD K + +
Sbjct: 126 KEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIK------RNTF 179
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKIEY 531
VGT +MAPE++ + AD+WS G T +E+ G PP M+P+ ++ LI K+
Sbjct: 180 VGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PP 237
Query: 532 NYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
D + + K F+D+CL+ DP+ R T+++ + H F+
Sbjct: 238 TLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 274
>sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
Length = 416
Score = 121 bits (304), Expect = 2e-27
Identities = 63/160 (39%), Positives = 97/160 (60%), Gaps = 3/160 (1%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
K+IL+ L YLH +K +HRDIK+ N+LL E +VKL DFG++ LTD K + +
Sbjct: 126 KEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIK------RNTF 179
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKIEY 531
VGT +MAPE++ + AD+WS G T +E+ G PP M+P+ ++ LI K+
Sbjct: 180 VGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKN----- 234
Query: 532 NYP---NDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
N P D + + K F+D+CL+ DP+ R T+++ + H F+
Sbjct: 235 NPPTLIGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 274
>sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2
Length = 589
Score = 120 bits (302), Expect = 3e-27
Identities = 60/154 (38%), Positives = 93/154 (60%)
Frame = +1
Query: 184 EALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSSVGTV 363
+ +Q+LH + I+HRDIKSDN+LLD N+K+ DFG L++ K + + VGT
Sbjct: 420 KGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNK------RVTMVGTP 473
Query: 364 NYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKIEYNYPN 543
+MAPE++ + G D+WS G ++EM+ PPY + +P+ + LI+K+ PN
Sbjct: 474 YWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPN 533
Query: 544 DLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFLS 645
+S NLKSF++SCL D R T+ + + H FL+
Sbjct: 534 LVSKNLKSFLNSCLTIDTIFRATAAELLTHSFLN 567
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 120 bits (301), Expect = 4e-27
Identities = 62/159 (38%), Positives = 99/159 (62%), Gaps = 2/159 (1%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
++IL+ L YLH +K +HRDIK+ N+LL E VKL DFG++ LTD K + +
Sbjct: 138 REILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK------RNTF 191
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSR--KI 525
VGT +MAPE++ + AD+WS G T +E+ G PP+ +++P+ ++ LI K+ +
Sbjct: 192 VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTL 251
Query: 526 EYNYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
E NY S LK FV++CL+ +P+ R T+++ + H F+
Sbjct: 252 EGNY----SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 120 bits (301), Expect = 4e-27
Identities = 62/159 (38%), Positives = 99/159 (62%), Gaps = 2/159 (1%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
++IL+ L YLH +K +HRDIK+ N+LL E VKL DFG++ LTD K + +
Sbjct: 126 REILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK------RNTF 179
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSR--KI 525
VGT +MAPE++ + AD+WS G T +E+ G PP+ +++P+ ++ LI K+ +
Sbjct: 180 VGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTL 239
Query: 526 EYNYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
E NY S LK FV++CL+ +P+ R T+++ + H F+
Sbjct: 240 EGNY----SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (p65-PAK)
Length = 544
Score = 119 bits (299), Expect = 7e-27
Identities = 62/157 (39%), Positives = 92/157 (58%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
++ L+AL +LH +++HRDIKSDNILL D +VKL DFG +T +K + +
Sbjct: 369 RECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK------RSTM 422
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKIEY 531
VGT +MAPE++ + G D+WS G +EMV G PPY NP+ + LI+ + E
Sbjct: 423 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL 482
Query: 532 NYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
P LS + F++ CL D RR ++++ + HPFL
Sbjct: 483 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519
>sp|O75914|PAK3_HUMAN Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (Oligophrenin-3)
sp|Q7YQL3|PAK3_PONPY Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
sp|Q7YQL4|PAK3_PANTR Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3)
Length = 559
Score = 119 bits (299), Expect = 7e-27
Identities = 62/157 (39%), Positives = 92/157 (58%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
++ L+AL +LH +++HRDIKSDNILL D +VKL DFG +T +K + +
Sbjct: 384 RECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK------RSTM 437
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKIEY 531
VGT +MAPE++ + G D+WS G +EMV G PPY NP+ + LI+ + E
Sbjct: 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL 497
Query: 532 NYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
P LS + F++ CL D RR ++++ + HPFL
Sbjct: 498 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 534
>sp|Q61036|PAK3_MOUSE Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B)
Length = 559
Score = 119 bits (299), Expect = 7e-27
Identities = 62/157 (39%), Positives = 92/157 (58%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
++ L+AL +LH +++HRDIKSDNILL D +VKL DFG +T +K + +
Sbjct: 384 RECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK------RSTM 437
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKIEY 531
VGT +MAPE++ + G D+WS G +EMV G PPY NP+ + LI+ + E
Sbjct: 438 VGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPEL 497
Query: 532 NYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
P LS + F++ CL D RR ++++ + HPFL
Sbjct: 498 QNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 534
>sp|Q13188|STK3_HUMAN Serine/threonine-protein kinase 3 (STE20-like kinase MST2) (MST-2)
(Mammalian STE20-like protein kinase 2)
(Serine/threonine-protein kinase Krs-1)
Length = 491
Score = 118 bits (295), Expect = 2e-26
Identities = 61/157 (38%), Positives = 91/157 (57%)
Frame = +1
Query: 172 KQILEALQYLHEQKILHRDIKSDNILLDEDDNVKLCDFGLSKILTDLAAKDFLNGVKQSS 351
K L+ L+YLH + +HRDIK+ NILL+ + + KL DFG++ LTD AK + +
Sbjct: 128 KSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK------RNTV 181
Query: 352 VGTVNYMAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHQMNPVCIISLISKSRKIEY 531
+GT +MAPE++ E AD+WS G T +EM G PPY ++P+ I +I + +
Sbjct: 182 IGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTF 241
Query: 532 NYPNDLSDNLKSFVDSCLHSDPARRLTSEQFMNHPFL 642
P SD+ FV CL +P +R T+ Q + HPF+
Sbjct: 242 RKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,428,817
Number of Sequences: 369166
Number of extensions: 1799817
Number of successful extensions: 8167
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5662
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6202
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)