Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01900
(849 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P46941|YLE5_CAEEL Hypothetical protein C38D4.5 in chromo... 114 4e-25
sp|Q8IWW6|RHG12_HUMAN Rho-GTPase-activating protein 12 108 2e-23
sp|Q8C0D4|RHG12_MOUSE Rho-GTPase-activating protein 12 108 2e-23
sp|Q9BE31|RHG12_MACFA Rho-GTPase-activating protein 12 107 3e-23
sp|Q9BRR9|RHG09_HUMAN Rho-GTPase-activating protein 9 105 1e-22
sp|P52757|CHIO_HUMAN Beta-chimaerin (Beta-chimerin) (Rho-GT... 73 1e-12
sp|P15882|CHIN_HUMAN N-chimaerin (NC) (N-chimerin) (Alpha c... 70 6e-12
sp|P30337|CHIN_RAT N-chimaerin (NC) (N-chimerin) (Alpha chi... 70 6e-12
sp|Q91V57|CHIN_MOUSE N-chimaerin (NC) (N-chimerin) (Alpha c... 70 7e-12
sp|Q80XD1|CHIO_MOUSE Beta-chimaerin (Beta-chimerin) (Rho-GT... 70 1e-11
>sp|P46941|YLE5_CAEEL Hypothetical protein C38D4.5 in chromosome III
Length = 837
Score = 114 bits (284), Expect = 4e-25
Identities = 64/202 (31%), Positives = 109/202 (53%)
Frame = +2
Query: 14 LKQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHS 193
L++F + RP+ ESL+ +GI KPE VFGS+L +C+ E + +P+F+ IE++GL
Sbjct: 583 LRRFFRTRPTVESLKEKGIYKPEPVFGSTLSAICQHENSLVPKFIRVITEVIESKGLETD 642
Query: 194 GIYRVSGNQAKIQKLRLAVDENKYQLNSEFMELETLTGAXXXXXXXXXXXXXXXXXCAKL 373
GIYRVSGN + +QK+R D++ Y+ ++ LTGA +
Sbjct: 643 GIYRVSGNLSAVQKIRCQADQDNYKALVSEEDIHVLTGALKLFFRELTDPLFPISLHKEY 702
Query: 374 IDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMDIG 553
+ A + ++L++++ + ET K L HL++VA+HSS+N M
Sbjct: 703 TSAMQMPNATTR-------FKKFEELLSRLPNENRETLKMLLRHLNRVASHSSQNRMQQH 755
Query: 554 NISMVWGPNLYSSTGQASTKMA 619
N+++V+GP L+ + G + +A
Sbjct: 756 NLAIVFGPTLFHN-GDGAVNLA 776
>sp|Q8IWW6|RHG12_HUMAN Rho-GTPase-activating protein 12
Length = 846
Score = 108 bits (270), Expect = 2e-23
Identities = 72/225 (32%), Positives = 116/225 (51%), Gaps = 2/225 (0%)
Frame = +2
Query: 14 LKQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHS 193
LK+FL RP+ +++ +G +K + VFGS+L LC++E +P+FV CI +E GL
Sbjct: 630 LKKFLTRRPTLQAVREKGYIKDQ-VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDID 688
Query: 194 GIYRVSGNQAKIQKLRLAVD-ENKYQLN-SEFMELETLTGAXXXXXXXXXXXXXXXXXCA 367
GIYRVSGN A IQKLR AV+ + K LN S++ ++ +TGA
Sbjct: 689 GIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFN 748
Query: 368 KLIDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMD 547
++ + + KD LI ++ + +T + LF HL +V + KN M
Sbjct: 749 DFVNAIKQEPRQRVAAVKD--------LIRQLPKPNQDTMQILFRHLRRVIENGEKNRMT 800
Query: 548 IGNISMVWGPNLYSSTGQASTKMAVLLMTHNQIIDFLITRYSDLF 682
+I++V+GP L + +AV + NQI++ ++ S +F
Sbjct: 801 YQSIAIVFGPTLLKPEKETG-NIAVHTVYQNQIVELILLELSSIF 844
>sp|Q8C0D4|RHG12_MOUSE Rho-GTPase-activating protein 12
Length = 838
Score = 108 bits (269), Expect = 2e-23
Identities = 72/225 (32%), Positives = 116/225 (51%), Gaps = 2/225 (0%)
Frame = +2
Query: 14 LKQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHS 193
LK+FL RP+ +++ +G +K + VFGS+L LC++E +P+FV CI +E GL
Sbjct: 622 LKKFLTRRPTLQAVREKGYIKDQ-VFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDVD 680
Query: 194 GIYRVSGNQAKIQKLRLAVD-ENKYQLN-SEFMELETLTGAXXXXXXXXXXXXXXXXXCA 367
GIYRVSGN A IQKLR AV+ + K LN S++ ++ +TGA
Sbjct: 681 GIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFN 740
Query: 368 KLIDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMD 547
++ + + KD LI ++ + +T + LF HL +V + KN M
Sbjct: 741 DFVNAIKQEPRQRVTAVKD--------LIRQLPKPNQDTMQILFRHLKRVIENGEKNRMT 792
Query: 548 IGNISMVWGPNLYSSTGQASTKMAVLLMTHNQIIDFLITRYSDLF 682
+I++V+GP L + +AV + NQI++ ++ S +F
Sbjct: 793 YQSIAIVFGPTLLKPERETG-NIAVHTVYQNQIVELILLELSTVF 836
>sp|Q9BE31|RHG12_MACFA Rho-GTPase-activating protein 12
Length = 847
Score = 107 bits (268), Expect = 3e-23
Identities = 72/225 (32%), Positives = 116/225 (51%), Gaps = 2/225 (0%)
Frame = +2
Query: 14 LKQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHS 193
LK+FL RP+ +++ +G +K + VFGS+L LC++E +P+FV CI +E GL
Sbjct: 631 LKKFLTRRPTLQAVREKGYIKDQ-VFGSNLANLCQRENGTVPKFVKLCIEHVEEYGLDVD 689
Query: 194 GIYRVSGNQAKIQKLRLAVD-ENKYQLN-SEFMELETLTGAXXXXXXXXXXXXXXXXXCA 367
GIYRVSGN A IQKLR AV+ + K LN S++ ++ +TGA
Sbjct: 690 GIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFN 749
Query: 368 KLIDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMD 547
++ + + KD LI ++ + +T + LF HL +V + KN M
Sbjct: 750 DFVNAIKQEPRQRVAAVKD--------LIRQLPKPNQDTMQILFRHLKRVVENGEKNRMT 801
Query: 548 IGNISMVWGPNLYSSTGQASTKMAVLLMTHNQIIDFLITRYSDLF 682
+I++V+GP L + +AV + NQI++ ++ S +F
Sbjct: 802 YQSIAIVFGPTLLKPEKETG-NIAVHTVYQNQIVELILLELSSIF 845
>sp|Q9BRR9|RHG09_HUMAN Rho-GTPase-activating protein 9
Length = 750
Score = 105 bits (263), Expect = 1e-22
Identities = 76/243 (31%), Positives = 120/243 (49%), Gaps = 20/243 (8%)
Frame = +2
Query: 14 LKQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHS 193
LK+ + RP +SL+ RG+L+ + VFG LE LC++E + +P F+ CI A++ RGL
Sbjct: 516 LKRLIAKRPPLQSLQERGLLRDQ-VFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVD 574
Query: 194 GIYRVSGNQAKIQKLRLAVD-------------------ENKYQLNS-EFMELETLTGAX 313
GIYRVSGN A +QKLR VD E + L+S E+ ++ +TGA
Sbjct: 575 GIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGAL 634
Query: 314 XXXXXXXXXXXXXXXXCAKLIDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKA 493
LL +A + + ++ ++LI M +++T +
Sbjct: 635 KLFLRELPQPLVPPL-------LLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRY 687
Query: 494 LFGHLHKVAAHSSKNYMDIGNISMVWGPNLYSSTGQASTKMAVLLMTHNQIIDFLITRYS 673
L HL +V AHS KN M N+ +V+GP L+ + S A L Q++ ++T ++
Sbjct: 688 LLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYP-GQLVQLMLTNFT 746
Query: 674 DLF 682
LF
Sbjct: 747 SLF 749
>sp|P52757|CHIO_HUMAN Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3)
Length = 468
Score = 72.8 bits (177), Expect = 1e-12
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 3/202 (1%)
Frame = +2
Query: 86 VFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHSGIYRVSGNQAKIQKLRLAVDENKY 265
V+ L L + + P V CI IEARGL G+YRVSG I+ +++A D +
Sbjct: 274 VYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGE 333
Query: 266 QLN---SEFMELETLTGAXXXXXXXXXXXXXXXXXCAKLIDLLSSRKADKKNTYKDININ 436
+ + + + ++ +TGA +K ID AD++ +
Sbjct: 334 KADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADER-------LE 386
Query: 437 TAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMDIGNISMVWGPNLYSSTGQASTKM 616
+++ + P+HYET + L HL KV + N+M+ N+ +V+GP L ++
Sbjct: 387 AVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPEDSTLTT 446
Query: 617 AVLLMTHNQIIDFLITRYSDLF 682
+ I+ LI LF
Sbjct: 447 LHDMRYQKLIVQILIENEDVLF 468
>sp|P15882|CHIN_HUMAN N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin)
(Rho-GTPase-activating protein 2)
Length = 459
Score = 70.5 bits (171), Expect = 6e-12
Identities = 53/195 (27%), Positives = 90/195 (46%), Gaps = 3/195 (1%)
Frame = +2
Query: 17 KQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHSG 196
KQ K+ P+ + + + K V+ L L + K P V CI IE+RGL+ G
Sbjct: 245 KQCSKMVPNDCKPDLKHVKK---VYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEG 301
Query: 197 IYRVSGNQAKIQKLRLAVDENKYQLN---SEFMELETLTGAXXXXXXXXXXXXXXXXXCA 367
+YRVSG I+ +++A D + + + + + ++ +TGA
Sbjct: 302 LYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYP 361
Query: 368 KLIDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMD 547
K I+ S++ D D + T + + + P+H ET + L HL +V H +N M+
Sbjct: 362 KFIE--SAKIMD-----PDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMN 414
Query: 548 IGNISMVWGPNLYSS 592
N+ +V+GP L S
Sbjct: 415 AENLGIVFGPTLMRS 429
>sp|P30337|CHIN_RAT N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin)
(Rho-GTPase-activating protein 2)
Length = 334
Score = 70.5 bits (171), Expect = 6e-12
Identities = 53/195 (27%), Positives = 89/195 (45%), Gaps = 3/195 (1%)
Frame = +2
Query: 17 KQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHSG 196
KQ K+ P+ + + + K V+ L L + K P V CI IE+RGL+ G
Sbjct: 120 KQCSKMVPNDCKPDLKHVKK---VYSCDLTTLVKAHITKRPMVVDMCIREIESRGLNSEG 176
Query: 197 IYRVSGNQAKIQKLRLAVDENKYQLN---SEFMELETLTGAXXXXXXXXXXXXXXXXXCA 367
+YRVSG I+ +++A D + + + + + ++ +TGA
Sbjct: 177 LYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYP 236
Query: 368 KLIDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMD 547
K I+ S++ D D + T + + + P+H ET + L HL +V H +N M
Sbjct: 237 KFIE--SAKIVDP-----DEQLETLHEALRSLPPAHCETLRYLMAHLKRVTLHEKENLMS 289
Query: 548 IGNISMVWGPNLYSS 592
N+ +V+GP L S
Sbjct: 290 AENLGIVFGPTLMRS 304
>sp|Q91V57|CHIN_MOUSE N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin)
(Rho-GTPase-activating protein 2)
Length = 334
Score = 70.1 bits (170), Expect = 7e-12
Identities = 51/195 (26%), Positives = 87/195 (44%), Gaps = 3/195 (1%)
Frame = +2
Query: 17 KQFLKIRPSPESLEARGILKPEAVFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHSG 196
KQ K+ P+ + + + K V+ L L + K P V CI IE+RGL+ G
Sbjct: 120 KQCSKMVPNDCKPDLKHVKK---VYSCDLTTLVKAHITKRPMVVDMCIREIESRGLNSEG 176
Query: 197 IYRVSGNQAKIQKLRLAVDENKYQLN---SEFMELETLTGAXXXXXXXXXXXXXXXXXCA 367
+YRVSG I+ +++A D + + + + + ++ +TGA
Sbjct: 177 LYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYP 236
Query: 368 KLIDLLSSRKADKKNTYKDININTAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMD 547
K I+ D++ + T + + + P+H ET + L HL +V H +N M
Sbjct: 237 KFIESAKIMDPDEQ-------LETLHEALRSLPPAHCETLRYLMAHLKRVTLHEKENLMS 289
Query: 548 IGNISMVWGPNLYSS 592
N+ +V+GP L S
Sbjct: 290 AENLGIVFGPTLMRS 304
>sp|Q80XD1|CHIO_MOUSE Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3)
Length = 332
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/202 (25%), Positives = 88/202 (43%), Gaps = 3/202 (1%)
Frame = +2
Query: 86 VFGSSLEILCEQEKNKIPEFVYRCILAIEARGLHHSGIYRVSGNQAKIQKLRLAVDEN-- 259
V+ L L + + P V CI IEARGL G+YRVSG I+ +++A D +
Sbjct: 138 VYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGE 197
Query: 260 KYQLNSE-FMELETLTGAXXXXXXXXXXXXXXXXXCAKLIDLLSSRKADKKNTYKDININ 436
K +++ + ++ +TGA +K I+ AD++ +
Sbjct: 198 KADISANIYPDINIITGALKLYFRDLPIPIITYDTYSKFIEAAKISNADER-------LE 250
Query: 437 TAKKLITKMKPSHYETGKALFGHLHKVAAHSSKNYMDIGNISMVWGPNLYSSTGQASTKM 616
+++ + P+HYET + L HL KV + N M+ N+ +V+GP L ++
Sbjct: 251 AVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNLMNAENLGIVFGPTLMRPPEDSTLTT 310
Query: 617 AVLLMTHNQIIDFLITRYSDLF 682
+ I+ LI LF
Sbjct: 311 LHDMRYQKLIVQILIENEDVLF 332
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,294,363
Number of Sequences: 369166
Number of extensions: 1616012
Number of successful extensions: 4049
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3866
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4015
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8341863645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)