Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01891
(714 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P08962|CD63_HUMAN CD63 antigen (Melanoma-associated anti... 85 2e-16
sp|P28648|CD63_RAT CD63 antigen (AD1 antigen) 81 2e-15
sp|P41731|CD63_MOUSE CD63 antigen 80 4e-15
sp|Q9XSK2|CD63_BOVIN CD63 antigen 80 4e-15
sp|Q28709|CD63_RABIT CD63 antigen 80 5e-15
sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane... 76 8e-14
sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane... 76 1e-13
sp|Q9DCK3|TSN4_MOUSE Tetraspanin-4 (Tspan-4) (Transmembrane... 73 7e-13
sp|P19331|IM23_SCHMA 23 kDa integral membrane protein (SM23) 73 7e-13
sp|Q62283|TSN7_MOUSE Tetraspanin-7 (Tspan-7) (Transmembrane... 72 1e-12
>sp|P08962|CD63_HUMAN CD63 antigen (Melanoma-associated antigen ME491)
(Lysosome-associated membrane glycoprotein 3) (LAMP-3)
(Ocular melanoma-associated antigen) (OMA81H)
(Granulophysin) (Tetraspanin-30) (Tspan-30)
Length = 238
Score = 84.7 bits (208), Expect = 2e-16
Identities = 51/206 (24%), Positives = 98/206 (47%), Gaps = 10/206 (4%)
Frame = +1
Query: 25 TYVKYLTKAIQLPILPALGLVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLF 204
T ++ T LP++ ++ VG+F+ +++ +G C CL+ TF I L +I+L
Sbjct: 42 TIIQGATPGSLLPVV-----IIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLV 96
Query: 205 QFAIAVSTFVLKNNIVKEFKKEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGIYNRT 384
+ A A++ +V ++ ++ EF +F + N + + + + +Q+ FKCCG N T
Sbjct: 97 EVAAAIAGYVFRDKVMSEFNN----NFRQQMENYPKNNHTASILDRMQADFKCCGAANYT 152
Query: 385 DY----SNKNMSIPSSCCLK-TEDCNIN----TAYTKGCLEDSKSYVEGILVSADLVXXX 537
D+ S +P SCC+ T C IN + +GC+E ++ ++
Sbjct: 153 DWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALG 212
Query: 538 XXXXXXXXXXFTFCLVRNLK-GYTMV 612
F CLV++++ GY ++
Sbjct: 213 IAFVEVLGIVFACCLVKSIRSGYEVM 238
>sp|P28648|CD63_RAT CD63 antigen (AD1 antigen)
Length = 238
Score = 81.3 bits (199), Expect = 2e-15
Identities = 47/187 (25%), Positives = 88/187 (47%), Gaps = 10/187 (5%)
Frame = +1
Query: 82 LVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAVSTFVLKNNIVKEF 261
+++ VG F+ +++ +G C CL+ TF I L +I+L + A+A++ +V ++ + EF
Sbjct: 56 VIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEF 115
Query: 262 KKEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGIYNRTDYSN----KNMSIPSSCCL 429
K SF+K N + +Q KCCG N TD+ +P SCC+
Sbjct: 116 SK----SFQKQMQNYLTDNKTATILDKLQKENKCCGASNYTDWERIPGMAKDRVPDSCCI 171
Query: 430 KT-----EDCNINTAYTKGCLEDSKSYVEGILVSADLVXXXXXXXXXXXXXFTFCLVRNL 594
D +T +T+GC+E +++ ++ F+ CLV+++
Sbjct: 172 NITVGCGNDFKESTIHTQGCVETIAAWLRKNVLLVAGAALGIAFVEVLGIIFSCCLVKSI 231
Query: 595 K-GYTMV 612
+ GY ++
Sbjct: 232 RSGYEVM 238
>sp|P41731|CD63_MOUSE CD63 antigen
Length = 238
Score = 80.5 bits (197), Expect = 4e-15
Identities = 46/187 (24%), Positives = 87/187 (46%), Gaps = 10/187 (5%)
Frame = +1
Query: 82 LVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAVSTFVLKNNIVKEF 261
+++ VG F+ +++ +G C CL+ TF I L +I+L + A+A++ +V ++ + EF
Sbjct: 56 VIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEF 115
Query: 262 KKEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGIYNRTDYSN----KNMSIPSSCCL 429
K SF++ N + +Q CCG N TD+ N +P SCC+
Sbjct: 116 NK----SFQQQMQNYLKDNKTATILDKLQKENNCCGASNYTDWENIPGMAKDRVPDSCCI 171
Query: 430 KT-----EDCNINTAYTKGCLEDSKSYVEGILVSADLVXXXXXXXXXXXXXFTFCLVRNL 594
D +T +T+GC+E ++ ++ F+ CLV+++
Sbjct: 172 NITVGCGNDFKESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLVKSI 231
Query: 595 K-GYTMV 612
+ GY ++
Sbjct: 232 RSGYEVM 238
>sp|Q9XSK2|CD63_BOVIN CD63 antigen
Length = 237
Score = 80.5 bits (197), Expect = 4e-15
Identities = 49/199 (24%), Positives = 93/199 (46%), Gaps = 9/199 (4%)
Frame = +1
Query: 43 TKAIQLPILPALGLVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAV 222
T + LP++ ++ VG F+ +++ +G C CL+ TF I L +I+L + A A+
Sbjct: 48 TPSFLLPVV-----IIAVGAFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAI 102
Query: 223 STFVLKNNIVKEFKKEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGIYNRTDYSN-- 396
+ +V ++ + EF K+ F + N + + +Q F+CCG N TD+
Sbjct: 103 AGYVFRDKVRSEFNKD----FRQQMKNYPKDNQTASILDKMQKDFECCGAANYTDWEKIL 158
Query: 397 -KNMSIPSSCCLK-TEDCNIN----TAYTKGCLEDSKSYVEGILVSADLVXXXXXXXXXX 558
+P SCC+ T +C IN +T+GC+E +++ ++
Sbjct: 159 AVTNKVPDSCCVNITHNCGINFVVKDIHTEGCVEKIAAWLRKNVLVVVAAALGIAFVEIL 218
Query: 559 XXXFTFCLVRNLK-GYTMV 612
CLV++++ GY ++
Sbjct: 219 GIVLACCLVKSIRSGYEVM 237
>sp|Q28709|CD63_RABIT CD63 antigen
Length = 238
Score = 80.1 bits (196), Expect = 5e-15
Identities = 47/187 (25%), Positives = 87/187 (46%), Gaps = 10/187 (5%)
Frame = +1
Query: 82 LVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAVSTFVLKNNIVKEF 261
+++ VG F+ +++ +G C CL+ TF I L +I+L + A A++ +V ++ ++ EF
Sbjct: 56 VIIAVGAFLFLVAFVGCCGTCKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEF 115
Query: 262 KKEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGIYNRTDYSN----KNMSIPSSCCL 429
K+ F + N S + +Q F CCG N TD++ +P SCC+
Sbjct: 116 NKD----FRQQMQNYSTDNQTALILDRMQKDFTCCGAANYTDWATIPGMTRDRVPDSCCV 171
Query: 430 K-TEDC----NINTAYTKGCLEDSKSYVEGILVSADLVXXXXXXXXXXXXXFTFCLVRNL 594
T C N+ Y +GC+E ++ ++ F CLV+++
Sbjct: 172 NVTSGCGVKFNVKDIYVEGCVEKIGLWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSI 231
Query: 595 K-GYTMV 612
+ GY ++
Sbjct: 232 RSGYEVM 238
>sp|O60637|TSN3_HUMAN Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A)
Length = 253
Score = 76.3 bits (186), Expect = 8e-14
Identities = 45/152 (29%), Positives = 80/152 (52%), Gaps = 15/152 (9%)
Frame = +1
Query: 64 ILPALGLVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAVSTFVLKN 243
++PA+ +++ VG + +I L+G C L+TF IIL+++ + + + V +V +
Sbjct: 51 LIPAV-VIIAVGALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRA 109
Query: 244 NIVKEFKKEMYISFEKAYS--NSSDSEYATNFFNYIQSSFKCCGIYNRTDYSN------- 396
+ E + S +K Y N ++ + A+ +Y+Q CCGI+N +D+ N
Sbjct: 110 KVENEVDR----SIQKVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKET 165
Query: 397 KNMSIPSSCCLKT-EDCNINTA-----YTKGC 474
KN S+P SCC +T +CN + A Y +GC
Sbjct: 166 KNQSVPLSCCRETASNCNGSLAHPSDLYAEGC 197
>sp|Q9QY33|TSN3_MOUSE Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8)
(Tetraspanin TM4-A) (OSP-associated protein 1) (OAP-1)
Length = 253
Score = 75.9 bits (185), Expect = 1e-13
Identities = 45/152 (29%), Positives = 79/152 (51%), Gaps = 15/152 (9%)
Frame = +1
Query: 64 ILPALGLVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAVSTFVLKN 243
+ PA+ +++ VG + +I L+G C L+TF IL+++ + + + V +V +
Sbjct: 51 LFPAV-VIIAVGALLFIIGLIGCCATIRESRCGLATFVFILLLVFVTEVVVVVLGYVYRA 109
Query: 244 NIVKEFKKEMYISFEKAYS--NSSDSEYATNFFNYIQSSFKCCGIYNRTDYSN------- 396
+ E + S +K Y N ++S+ A+ +Y+Q CCGI+N +D+ N
Sbjct: 110 KVENEVDR----SIQKVYKTYNGTNSDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKET 165
Query: 397 KNMSIPSSCCLKT-EDCNINTA-----YTKGC 474
KN S+P SCC +T + CN + A Y +GC
Sbjct: 166 KNQSVPLSCCRETAKSCNGSLANPSDLYAEGC 197
>sp|Q9DCK3|TSN4_MOUSE Tetraspanin-4 (Tspan-4) (Transmembrane 4 superfamily member 7)
Length = 238
Score = 73.2 bits (178), Expect = 7e-13
Identities = 47/177 (26%), Positives = 87/177 (49%), Gaps = 10/177 (5%)
Frame = +1
Query: 25 TYVKYLTKAIQLPILPALGLVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLF 204
T + T + P L A L++ G F++ I +G + CLL TF ++L+++ L
Sbjct: 37 TQGNFATLSSSFPSLSAANLLIVTGTFVMAIGFVGCIGALKENKCLLLTFFVLLLLVFLL 96
Query: 205 QFAIAVSTFVLKNNI----VKEFKKEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGI 372
+ IAV F + I ++ KK +++ + + TN ++ IQ+ F+CCG+
Sbjct: 97 EATIAVLFFAYSDKIDSYAQQDLKKGLHL------YGTQGNVGLTNAWSIIQTDFRCCGV 150
Query: 373 YNRTDYSN--KNMSIPSSCCLKTED-CNIN---TAYTKGCLEDSKSYVEGILVSADL 525
N TD+ +P SCCL+ D C ++ T + C E K++++ L++ +
Sbjct: 151 SNYTDWFEVYNATRVPDSCCLEFSDSCGLHEPGTWWKSPCYETVKAWLQENLLAVGI 207
>sp|P19331|IM23_SCHMA 23 kDa integral membrane protein (SM23)
Length = 218
Score = 73.2 bits (178), Expect = 7e-13
Identities = 51/176 (28%), Positives = 79/176 (44%)
Frame = +1
Query: 85 VMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAVSTFVLKNNIVKEFK 264
++ VG+ I+++S LG C+L + L+V+L+ + A A+ V K+ I E
Sbjct: 58 IIVVGVIILIVSFLGCCGAIKENVCMLYMYAFFLVVLLIAELAAAIVAVVYKDRIDSEID 117
Query: 265 KEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGIYNRTDYSNKNMSIPSSCCLKTEDC 444
M + +K ++ T F N IQSSF CCG DY ++P+SC K E
Sbjct: 118 ALMTGALDK------PTKEITEFMNLIQSSFHCCGAKGPDDYRG---NVPASC--KEE-- 164
Query: 445 NINTAYTKGCLEDSKSYVEGILVSADLVXXXXXXXXXXXXXFTFCLVRNLKGYTMV 612
N YT+GC+ ++++ LV V CL R +K Y V
Sbjct: 165 --NLTYTEGCVSVFGAFLKRNLVIVACVAFGVCFFQLLSIVIACCLGRQIKEYENV 218
>sp|Q62283|TSN7_MOUSE Tetraspanin-7 (Tspan-7) (Transmembrane 4 superfamily member 2)
(Cell surface glycoprotein A15) (PE31) (TALLA homolog)
Length = 249
Score = 72.0 bits (175), Expect = 1e-12
Identities = 41/154 (26%), Positives = 74/154 (48%), Gaps = 14/154 (9%)
Frame = +1
Query: 82 LVMGVGIFIIVISLLGMLTGCTAKPCLLSTFGIILIVILLFQFAIAVSTFVLKNNIVKEF 261
+++G G I+V L G C P +L + + L ++ L + +S FV ++ I F
Sbjct: 61 VLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTF 120
Query: 262 KKEMYISFEKAYSNSSDSEYATNFFNYIQSSFKCCGIYNRTDYSNK----NMSIPSSCCL 429
+ ++ A N + ++ + +++Q S CCG+ N T++S+ + IP SCC+
Sbjct: 121 LR----TYTDAMQNYNGNDERSRAVDHVQRSLSCCGVQNYTNWSSSPYFLDHGIPPSCCM 176
Query: 430 KTEDC------NINTAYT----KGCLEDSKSYVE 501
DC N+ A T KGC + S++E
Sbjct: 177 NETDCNPLDLHNLTVAATKVNQKGCYDLVTSFME 210
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,912,815
Number of Sequences: 369166
Number of extensions: 1269425
Number of successful extensions: 3659
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3542
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3629
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6316483550
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)