Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01876
(847 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8VHQ2|SOCS7_MOUSE Suppressor of cytokine signaling 7 (S... 142 2e-33
sp|O14512|SOCS7_HUMAN Suppressor of cytokine signaling 7 (S... 142 2e-33
sp|Q9JLY0|SOCS6_MOUSE Suppressor of cytokine signaling 6 (S... 125 2e-28
sp|O14544|SOCS6_HUMAN Suppressor of cytokine signaling 6 (S... 125 2e-28
sp|Q8WXH5|SOCS4_HUMAN Suppressor of cytokine signaling 4 (S... 62 2e-09
sp|Q91ZA6|SOCS4_MOUSE Suppressor of cytokine signaling 4 (S... 60 6e-09
sp|Q9PW70|CISH_CHICK Cytokine-inducible SH2-containing prot... 59 2e-08
sp|O75159|SOCS5_HUMAN Cytokine inducible SH2-containing pro... 58 4e-08
sp|O54928|SOCS5_MOUSE Cytokine inducible SH2-containing pro... 58 4e-08
sp|O14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (S... 56 1e-07
>sp|Q8VHQ2|SOCS7_MOUSE Suppressor of cytokine signaling 7 (SOCS-7)
Length = 579
Score = 142 bits (357), Expect = 2e-33
Identities = 72/153 (47%), Positives = 100/153 (65%), Gaps = 1/153 (0%)
Frame = +1
Query: 10 RPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHS-ATTIVEFID 186
+PDG+FLVRDS+ Y LSL+FR G T+HTR+E+ +G FS W P+ ++VEFI
Sbjct: 415 KPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIK 474
Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
+A+ HS +GKF YFL++ PG PP V LLYP+SR+ V+SLQHL RF I +R DH+
Sbjct: 475 RAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIP 534
Query: 367 QLQLPSSLKGYLLEKQYYIDNIDAFVKLTKDAE 465
L LP L Y+ + YY + ++ L K+A+
Sbjct: 535 DLPLPKPLISYIRKFYYYDPQEEVYLSL-KEAQ 566
>sp|O14512|SOCS7_HUMAN Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and
phospholipase C gamma-binding protein) (Nck-associated
protein 4) (NAP-4)
Length = 485
Score = 142 bits (357), Expect = 2e-33
Identities = 72/153 (47%), Positives = 100/153 (65%), Gaps = 1/153 (0%)
Frame = +1
Query: 10 RPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHS-ATTIVEFID 186
+PDG+FLVRDS+ Y LSL+FR G T+HTR+E+ +G FS W P+ ++VEFI
Sbjct: 294 KPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIK 353
Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
+A+ HS +GKF YFL++ PG PP V LLYP+SR+ V+SLQHL RF I +R DH+
Sbjct: 354 RAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIP 413
Query: 367 QLQLPSSLKGYLLEKQYYIDNIDAFVKLTKDAE 465
L LP L Y+ + YY + ++ L K+A+
Sbjct: 414 DLPLPKPLISYIRKFYYYDPQEEVYLSL-KEAQ 445
>sp|Q9JLY0|SOCS6_MOUSE Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine
signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4)
(CIS-4)
Length = 533
Score = 125 bits (313), Expect = 2e-28
Identities = 66/137 (48%), Positives = 89/137 (64%)
Frame = +1
Query: 7 NRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEFID 186
N PDG+FLVRDS+ D Y LSL+FR G T HTRIE+S G+FSF+ QP+ T+IV+ I+
Sbjct: 398 NVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIE 457
Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
++ S +G F Y ++ PG V L P+SR+ V+SLQ+L RFVI R D +
Sbjct: 458 HSIRDSENGAFCY-SRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQ 516
Query: 367 QLQLPSSLKGYLLEKQY 417
+L LP+ +K YL EK Y
Sbjct: 517 KLPLPNKMKDYLQEKHY 533
>sp|O14544|SOCS6_HUMAN Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine
signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4)
(CIS-4)
Length = 535
Score = 125 bits (313), Expect = 2e-28
Identities = 66/137 (48%), Positives = 89/137 (64%)
Frame = +1
Query: 7 NRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEFID 186
N PDG+FLVRDS+ D Y LSL+FR G T HTRIE+S G+FSF+ QP+ T+IV+ I+
Sbjct: 400 NVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIE 459
Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
++ S +G F Y ++ PG V L P+SR+ V+SLQ+L RFVI R D +
Sbjct: 460 HSIRDSENGAFCY-SRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQ 518
Query: 367 QLQLPSSLKGYLLEKQY 417
+L LP+ +K YL EK Y
Sbjct: 519 KLPLPNKMKDYLQEKHY 535
>sp|Q8WXH5|SOCS4_HUMAN Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine
signaling 7) (SOCS-7)
Length = 440
Score = 62.4 bits (150), Expect = 2e-09
Identities = 46/145 (31%), Positives = 69/145 (47%), Gaps = 6/145 (4%)
Frame = +1
Query: 1 VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
++ +P+GTFL+RDSA + Y S++FR + H RIE FSF ++H
Sbjct: 300 LEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSF----DAH-------- 347
Query: 181 IDKAVAHS--ASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQ----SLQHLSRFVILS 342
D V HS +G ++ + P PL +++ SLQH+ R VI +
Sbjct: 348 -DPCVFHSPDITGLLEHY-------KDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICN 399
Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
D + L +PSS+K YL E Y
Sbjct: 400 CTTYDGIDALPIPSSMKLYLKEYHY 424
>sp|Q91ZA6|SOCS4_MOUSE Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine
signaling 7) (SOCS-7)
Length = 436
Score = 60.5 bits (145), Expect = 6e-09
Identities = 45/145 (31%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
Frame = +1
Query: 1 VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
++ +P+GTFL+RDSA + Y S++FR + H RIE FSF ++H
Sbjct: 297 LEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSF----DAH-------- 344
Query: 181 IDKAVAHS--ASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQ----SLQHLSRFVILS 342
D V HS +G ++ + P PL +++ SLQH+ R VI +
Sbjct: 345 -DPCVFHSPDITGLLEHY-------KDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICN 396
Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
D + L +PS +K YL E Y
Sbjct: 397 CTTYDGIDALPIPSPMKLYLKEYHY 421
>sp|Q9PW70|CISH_CHICK Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor
of cytokine signaling) (SOCS)
Length = 249
Score = 58.9 bits (141), Expect = 2e-08
Identities = 48/153 (31%), Positives = 68/153 (44%), Gaps = 18/153 (11%)
Frame = +1
Query: 13 PDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKF----SFWSQPESHSATTIVEF 180
P+GTFLVRDS H +Y +L+ + + RIEY+ KF ++ S+P + +V
Sbjct: 102 PEGTFLVRDSTHPSYLFTLSVKTNRGPTNVRIEYADSKFRLDSNYLSKPRILAFPDVVSL 161
Query: 181 IDKAVAHSASGKFHYFLQTSTPGQPP--------------MEVSLLYPLSRYQVVQSLQH 318
I V + ++ P PP + + LL PL R + SLQH
Sbjct: 162 IQHYVTSCTTES-----KSEAPYPPPAPLPPVQKEVAVAAVHLKLLRPLGRRDSIPSLQH 216
Query: 319 LSRFVILSNIRKDHVSQLQLPSSLKGYLLEKQY 417
L R I N V +L LP + YL KQY
Sbjct: 217 LCRLRI--NRCTTEVERLPLPRRMGDYL--KQY 245
>sp|O75159|SOCS5_HUMAN Cytokine inducible SH2-containing protein 5 (Suppressor of cytokine
signaling 5) (SOCS-5) (Cytokine-inducible SH2 protein 6)
(CIS-6)
Length = 536
Score = 57.8 bits (138), Expect = 4e-08
Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 6/145 (4%)
Frame = +1
Query: 1 VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
++ +P+GTFL+RDSA + Y S++FR + H RIE FSF ++H
Sbjct: 395 LEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSF----DAH-------- 442
Query: 181 IDKAVAHSA--SGKFHYFLQTSTP--GQPPMEVSL--LYPLSRYQVVQSLQHLSRFVILS 342
D V HS+ +G ++ S+ +P + +SL +P SLQ++ R VI
Sbjct: 443 -DPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPF-------SLQYICRAVICR 494
Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
D + L LPS L+ +L E Y
Sbjct: 495 CTTYDGIDGLPLPSMLQDFLKEYHY 519
>sp|O54928|SOCS5_MOUSE Cytokine inducible SH2-containing protein 5 (Suppressor of cytokine
signaling 5) (SOCS-5)
Length = 536
Score = 57.8 bits (138), Expect = 4e-08
Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 6/145 (4%)
Frame = +1
Query: 1 VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
++ +P+GTFL+RDSA + Y S++FR + H RIE FSF ++H
Sbjct: 395 LEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSF----DAH-------- 442
Query: 181 IDKAVAHSA--SGKFHYFLQTSTP--GQPPMEVSL--LYPLSRYQVVQSLQHLSRFVILS 342
D V HS+ +G ++ S+ +P + +SL +P SLQ++ R VI
Sbjct: 443 -DPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPF-------SLQYICRAVICR 494
Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
D + L LPS L+ +L E Y
Sbjct: 495 CTTYDGIDGLPLPSMLQDFLKEYHY 519
>sp|O14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2
protein 2) (CIS-2) (STAT-induced STAT inhibitor 2)
(SSI-2)
Length = 198
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/141 (31%), Positives = 64/141 (45%), Gaps = 4/141 (2%)
Frame = +1
Query: 13 PDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWS----QPESHSATTIVEF 180
P+GTFL+RDS+H Y L+++ + + RIEY GKF S + + ++V
Sbjct: 66 PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL 125
Query: 181 IDKAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDH 360
ID V + P + + L PL Y SLQHL R I N
Sbjct: 126 IDYYVQMCKDKR----TGPEAPRNGTVHLYLTKPL--YTSAPSLQHLCRLTI--NKCTGA 177
Query: 361 VSQLQLPSSLKGYLLEKQYYI 423
+ L LP+ LK YL E ++ +
Sbjct: 178 IWGLPLPTRLKDYLEEYKFQV 198
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,029,929
Number of Sequences: 369166
Number of extensions: 1489971
Number of successful extensions: 4092
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3925
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4071
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)