Planaria EST Database


DrC_01876

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01876
         (847 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q8VHQ2|SOCS7_MOUSE  Suppressor of cytokine signaling 7 (S...   142   2e-33
sp|O14512|SOCS7_HUMAN  Suppressor of cytokine signaling 7 (S...   142   2e-33
sp|Q9JLY0|SOCS6_MOUSE  Suppressor of cytokine signaling 6 (S...   125   2e-28
sp|O14544|SOCS6_HUMAN  Suppressor of cytokine signaling 6 (S...   125   2e-28
sp|Q8WXH5|SOCS4_HUMAN  Suppressor of cytokine signaling 4 (S...    62   2e-09
sp|Q91ZA6|SOCS4_MOUSE  Suppressor of cytokine signaling 4 (S...    60   6e-09
sp|Q9PW70|CISH_CHICK  Cytokine-inducible SH2-containing prot...    59   2e-08
sp|O75159|SOCS5_HUMAN  Cytokine inducible SH2-containing pro...    58   4e-08
sp|O54928|SOCS5_MOUSE  Cytokine inducible SH2-containing pro...    58   4e-08
sp|O14508|SOCS2_HUMAN  Suppressor of cytokine signaling 2 (S...    56   1e-07
>sp|Q8VHQ2|SOCS7_MOUSE Suppressor of cytokine signaling 7 (SOCS-7)
          Length = 579

 Score =  142 bits (357), Expect = 2e-33
 Identities = 72/153 (47%), Positives = 100/153 (65%), Gaps = 1/153 (0%)
 Frame = +1

Query: 10  RPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHS-ATTIVEFID 186
           +PDG+FLVRDS+   Y LSL+FR  G T+HTR+E+ +G FS W  P+      ++VEFI 
Sbjct: 415 KPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIK 474

Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
           +A+ HS +GKF YFL++  PG PP  V LLYP+SR+  V+SLQHL RF I   +R DH+ 
Sbjct: 475 RAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIP 534

Query: 367 QLQLPSSLKGYLLEKQYYIDNIDAFVKLTKDAE 465
            L LP  L  Y+ +  YY    + ++ L K+A+
Sbjct: 535 DLPLPKPLISYIRKFYYYDPQEEVYLSL-KEAQ 566
>sp|O14512|SOCS7_HUMAN Suppressor of cytokine signaling 7 (SOCS-7) (Nck, Ash and
           phospholipase C gamma-binding protein) (Nck-associated
           protein 4) (NAP-4)
          Length = 485

 Score =  142 bits (357), Expect = 2e-33
 Identities = 72/153 (47%), Positives = 100/153 (65%), Gaps = 1/153 (0%)
 Frame = +1

Query: 10  RPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHS-ATTIVEFID 186
           +PDG+FLVRDS+   Y LSL+FR  G T+HTR+E+ +G FS W  P+      ++VEFI 
Sbjct: 294 KPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTFSLWCHPKFEDRCQSVVEFIK 353

Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
           +A+ HS +GKF YFL++  PG PP  V LLYP+SR+  V+SLQHL RF I   +R DH+ 
Sbjct: 354 RAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVKSLQHLCRFRIRQLVRIDHIP 413

Query: 367 QLQLPSSLKGYLLEKQYYIDNIDAFVKLTKDAE 465
            L LP  L  Y+ +  YY    + ++ L K+A+
Sbjct: 414 DLPLPKPLISYIRKFYYYDPQEEVYLSL-KEAQ 445
>sp|Q9JLY0|SOCS6_MOUSE Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine
           signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4)
           (CIS-4)
          Length = 533

 Score =  125 bits (313), Expect = 2e-28
 Identities = 66/137 (48%), Positives = 89/137 (64%)
 Frame = +1

Query: 7   NRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEFID 186
           N PDG+FLVRDS+ D Y LSL+FR  G T HTRIE+S G+FSF+ QP+    T+IV+ I+
Sbjct: 398 NVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIE 457

Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
            ++  S +G F Y  ++  PG     V L  P+SR+  V+SLQ+L RFVI    R D + 
Sbjct: 458 HSIRDSENGAFCY-SRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQ 516

Query: 367 QLQLPSSLKGYLLEKQY 417
           +L LP+ +K YL EK Y
Sbjct: 517 KLPLPNKMKDYLQEKHY 533
>sp|O14544|SOCS6_HUMAN Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine
           signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4)
           (CIS-4)
          Length = 535

 Score =  125 bits (313), Expect = 2e-28
 Identities = 66/137 (48%), Positives = 89/137 (64%)
 Frame = +1

Query: 7   NRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEFID 186
           N PDG+FLVRDS+ D Y LSL+FR  G T HTRIE+S G+FSF+ QP+    T+IV+ I+
Sbjct: 400 NVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIE 459

Query: 187 KAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDHVS 366
            ++  S +G F Y  ++  PG     V L  P+SR+  V+SLQ+L RFVI    R D + 
Sbjct: 460 HSIRDSENGAFCY-SRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQ 518

Query: 367 QLQLPSSLKGYLLEKQY 417
           +L LP+ +K YL EK Y
Sbjct: 519 KLPLPNKMKDYLQEKHY 535
>sp|Q8WXH5|SOCS4_HUMAN Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine
           signaling 7) (SOCS-7)
          Length = 440

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 46/145 (31%), Positives = 69/145 (47%), Gaps = 6/145 (4%)
 Frame = +1

Query: 1   VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
           ++ +P+GTFL+RDSA + Y  S++FR    + H RIE     FSF    ++H        
Sbjct: 300 LEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSF----DAH-------- 347

Query: 181 IDKAVAHS--ASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQ----SLQHLSRFVILS 342
            D  V HS   +G   ++       + P       PL    +++    SLQH+ R VI +
Sbjct: 348 -DPCVFHSPDITGLLEHY-------KDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICN 399

Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
               D +  L +PSS+K YL E  Y
Sbjct: 400 CTTYDGIDALPIPSSMKLYLKEYHY 424
>sp|Q91ZA6|SOCS4_MOUSE Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine
           signaling 7) (SOCS-7)
          Length = 436

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 45/145 (31%), Positives = 68/145 (46%), Gaps = 6/145 (4%)
 Frame = +1

Query: 1   VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
           ++ +P+GTFL+RDSA + Y  S++FR    + H RIE     FSF    ++H        
Sbjct: 297 LEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSF----DAH-------- 344

Query: 181 IDKAVAHS--ASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQ----SLQHLSRFVILS 342
            D  V HS   +G   ++       + P       PL    +++    SLQH+ R VI +
Sbjct: 345 -DPCVFHSPDITGLLEHY-------KDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICN 396

Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
               D +  L +PS +K YL E  Y
Sbjct: 397 CTTYDGIDALPIPSPMKLYLKEYHY 421
>sp|Q9PW70|CISH_CHICK Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor
           of cytokine signaling) (SOCS)
          Length = 249

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 48/153 (31%), Positives = 68/153 (44%), Gaps = 18/153 (11%)
 Frame = +1

Query: 13  PDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKF----SFWSQPESHSATTIVEF 180
           P+GTFLVRDS H +Y  +L+ +      + RIEY+  KF    ++ S+P   +   +V  
Sbjct: 102 PEGTFLVRDSTHPSYLFTLSVKTNRGPTNVRIEYADSKFRLDSNYLSKPRILAFPDVVSL 161

Query: 181 IDKAVAHSASGKFHYFLQTSTPGQPP--------------MEVSLLYPLSRYQVVQSLQH 318
           I   V    +       ++  P  PP              + + LL PL R   + SLQH
Sbjct: 162 IQHYVTSCTTES-----KSEAPYPPPAPLPPVQKEVAVAAVHLKLLRPLGRRDSIPSLQH 216

Query: 319 LSRFVILSNIRKDHVSQLQLPSSLKGYLLEKQY 417
           L R  I  N     V +L LP  +  YL  KQY
Sbjct: 217 LCRLRI--NRCTTEVERLPLPRRMGDYL--KQY 245
>sp|O75159|SOCS5_HUMAN Cytokine inducible SH2-containing protein 5 (Suppressor of cytokine
           signaling 5) (SOCS-5) (Cytokine-inducible SH2 protein 6)
           (CIS-6)
          Length = 536

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 6/145 (4%)
 Frame = +1

Query: 1   VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
           ++ +P+GTFL+RDSA + Y  S++FR    + H RIE     FSF    ++H        
Sbjct: 395 LEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSF----DAH-------- 442

Query: 181 IDKAVAHSA--SGKFHYFLQTSTP--GQPPMEVSL--LYPLSRYQVVQSLQHLSRFVILS 342
            D  V HS+  +G   ++   S+    +P + +SL   +P        SLQ++ R VI  
Sbjct: 443 -DPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPF-------SLQYICRAVICR 494

Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
               D +  L LPS L+ +L E  Y
Sbjct: 495 CTTYDGIDGLPLPSMLQDFLKEYHY 519
>sp|O54928|SOCS5_MOUSE Cytokine inducible SH2-containing protein 5 (Suppressor of cytokine
           signaling 5) (SOCS-5)
          Length = 536

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 6/145 (4%)
 Frame = +1

Query: 1   VDNRPDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWSQPESHSATTIVEF 180
           ++ +P+GTFL+RDSA + Y  S++FR    + H RIE     FSF    ++H        
Sbjct: 395 LEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSF----DAH-------- 442

Query: 181 IDKAVAHSA--SGKFHYFLQTSTP--GQPPMEVSL--LYPLSRYQVVQSLQHLSRFVILS 342
            D  V HS+  +G   ++   S+    +P + +SL   +P        SLQ++ R VI  
Sbjct: 443 -DPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPF-------SLQYICRAVICR 494

Query: 343 NIRKDHVSQLQLPSSLKGYLLEKQY 417
               D +  L LPS L+ +L E  Y
Sbjct: 495 CTTYDGIDGLPLPSMLQDFLKEYHY 519
>sp|O14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2
           protein 2) (CIS-2) (STAT-induced STAT inhibitor 2)
           (SSI-2)
          Length = 198

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 44/141 (31%), Positives = 64/141 (45%), Gaps = 4/141 (2%)
 Frame = +1

Query: 13  PDGTFLVRDSAHDTYFLSLTFRVLGTTYHTRIEYSQGKFSFWS----QPESHSATTIVEF 180
           P+GTFL+RDS+H  Y L+++ +      + RIEY  GKF   S    + +     ++V  
Sbjct: 66  PEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHL 125

Query: 181 IDKAVAHSASGKFHYFLQTSTPGQPPMEVSLLYPLSRYQVVQSLQHLSRFVILSNIRKDH 360
           ID  V      +         P    + + L  PL  Y    SLQHL R  I  N     
Sbjct: 126 IDYYVQMCKDKR----TGPEAPRNGTVHLYLTKPL--YTSAPSLQHLCRLTI--NKCTGA 177

Query: 361 VSQLQLPSSLKGYLLEKQYYI 423
           +  L LP+ LK YL E ++ +
Sbjct: 178 IWGLPLPTRLKDYLEEYKFQV 198
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,029,929
Number of Sequences: 369166
Number of extensions: 1489971
Number of successful extensions: 4092
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3925
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4071
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)