Planaria EST Database


DrC_01841

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01841
         (886 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|P35556|FBN2_HUMAN  Fibrillin-2 precursor                       144   4e-34
sp|Q61555|FBN2_MOUSE  Fibrillin-2 precursor                       141   2e-33
sp|P35555|FBN1_HUMAN  Fibrillin-1 precursor                       139   1e-32
sp|P98133|FBN1_BOVIN  Fibrillin-1 precursor (MP340)               138   2e-32
sp|Q9TV36|FBN1_PIG  Fibrillin-1 precursor                         137   5e-32
sp|Q61554|FBN1_MOUSE  Fibrillin-1 precursor                       136   7e-32
sp|O77469|FBLN1_CAEEL  Fibulin-1 precursor                        134   3e-31
sp|Q75N90|FBN3_HUMAN  Fibrillin-3 precursor                       134   3e-31
sp|Q8CG18|LTB1S_MOUSE  Latent transforming growth factor bet...   131   3e-30
sp|Q8CG19|LTB1L_MOUSE  Latent transforming growth factor bet...   131   3e-30
>sp|P35556|FBN2_HUMAN Fibrillin-2 precursor
          Length = 2911

 Score =  144 bits (362), Expect = 4e-34
 Identities = 77/232 (33%), Positives = 108/232 (46%)
 Frame = +1

Query: 115  YYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCD 294
            +++  C  GRCI   + YRCEC   +  D  G                           D
Sbjct: 499  HHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCI----------------------DVD 536

Query: 295  KFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGS 474
            +  S  C NG C+ +  SY CKC+ GFQ +   + C DIDEC  N  +C  G C+NS GS
Sbjct: 537  ECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNSDGS 596

Query: 475  YQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQ 654
            +QC C  GF +     G  C D +EC+   ++C NG+CIN  GSFKC C  G+V + N +
Sbjct: 597  FQCICNAGFEL--TTDGKNCVDHDECT-TTNMCLNGMCINEDGSFKCICKPGFVLAPNGR 653

Query: 655  DCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             C  + D      +  N         +C    G+F+C CP G+   +D  +C
Sbjct: 654  YCTDV-DECQTPGICMNG--------HCINSEGSFRCDCPPGLAVGMDGRVC 696

 Score =  140 bits (353), Expect = 5e-33
 Identities = 77/226 (34%), Positives = 98/226 (43%)
 Frame = +1

Query: 103  CSFSYYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLK 282
            CS S     C+ G+C+NM   Y+C C P +      Q C            D      + 
Sbjct: 1203 CSLS--DNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGC-----------TDIDECMIMN 1249

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCIN 462
              CD          +C  S  SYEC C+ G+    DG+ C+DIDEC  NP ICD G C N
Sbjct: 1250 GGCDT---------QCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTN 1300

Query: 463  SPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
             PG Y+C CYDGF          C D NEC  + ++C  G C N  GSF C C  GY   
Sbjct: 1301 IPGEYRCLCYDGFMA--SMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVK 1358

Query: 643  SNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
                 C      +D    +  +  C   +  C  + G+FKCSC  G
Sbjct: 1359 KGTTGC------TDVDECEIGAHNCDMHAS-CLNIPGSFKCSCREG 1397

 Score =  136 bits (342), Expect = 9e-32
 Identities = 73/229 (31%), Positives = 106/229 (46%), Gaps = 1/229 (0%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C N    ++C C   F LD + + C    E +                       
Sbjct: 1083 CTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECR-------------------ISPD 1123

Query: 310  LCKNGRCIESGSSYECKCNLGFQES-SDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
            LC +G C+ +  S+EC+C  G++      K C DID C  NP +C  GTC+N+ GS+QC 
Sbjct: 1124 LCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDGCERNPLLCRGGTCVNTEGSFQCD 1183

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  G  +   P    C D NECS   +LC+NG C+N+ G+++C CN GY A+ ++Q C  
Sbjct: 1184 CPLGHELS--PSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTD 1241

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCA 813
            I         D+       C   C    G+++CSC  G   + D   CA
Sbjct: 1242 I---------DECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA 1281

 Score =  130 bits (328), Expect = 4e-30
 Identities = 71/214 (33%), Positives = 95/214 (44%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N    Y C C P F L                  ND         +C  F   
Sbjct: 1942 CGNGTCKNTVGSYNCLCYPGFELTHN---------------NDCLDI----DECSSFFGQ 1982

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +C+NGRC     S++C CN G++ + DGK C D +EC   P  C  GTC N  GS++C C
Sbjct: 1983 VCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCIC 2042

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
              G+ + +      C D NEC ED ++C  G C N  G F+C C  G+V S N + C   
Sbjct: 2043 PPGYEVKS----ENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDT 2098

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
            + S  ++  ++      KCS   AF     KC C
Sbjct: 2099 RQSFCFTNFEN-----GKCSVPKAFNTTKAKCCC 2127

 Score =  129 bits (324), Expect = 1e-29
 Identities = 59/176 (33%), Positives = 96/176 (54%)
 Frame = +1

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCIN 462
            ++C  F   +C  G+C  +  S++C+CN GF    + + C+DIDEC  +P +C  G C+N
Sbjct: 1074 NECKAFPG-MCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVN 1132

Query: 463  SPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
            +PGS++C C++G+    M     C D + C  +  LC+ G C+N  GSF+C C  G+  S
Sbjct: 1133 TPGSFECECFEGYESGFMM-MKNCMDIDGCERNPLLCRGGTCVNTEGSFQCDCPLGHELS 1191

Query: 643  SNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             +++DC+ I + S    +  N K        C  + GT++CSC  G ++  D   C
Sbjct: 1192 PSREDCVDINECSLSDNLCRNGK--------CVNMIGTYQCSCNPGYQATPDRQGC 1239

 Score =  122 bits (307), Expect = 1e-27
 Identities = 80/294 (27%), Positives = 111/294 (37%), Gaps = 67/294 (22%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            CK GRC+N    ++C C   F L   G+ C    E     M                   
Sbjct: 585  CKNGRCVNSDGSFQCICNAGFELTTDGKNCVDHDECTTTNM------------------- 625

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQC-- 483
             C NG CI    S++C C  GF  + +G+ C+D+DEC T P IC  G CINS GS++C  
Sbjct: 626  -CLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQT-PGICMNGHCINSEGSFRCDC 683

Query: 484  --------------------SCYDGFT----IHNMPG----------------GPKCY-- 537
                                +CY G      +   PG                G  C   
Sbjct: 684  PPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPC 743

Query: 538  -----------------------DRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSN 648
                                   D NEC+ D  +C NG+C N+ GS++C CNSGY   ++
Sbjct: 744  PAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCNSGYEPDAS 803

Query: 649  KQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             ++CI I +      + DN          C    G++ C+CP G     +T  C
Sbjct: 804  GRNCIDIDECLVNRLLCDNG--------LCRNTPGSYSCTCPPGYVFRTETETC 849

 Score =  120 bits (300), Expect = 7e-27
 Identities = 73/266 (27%), Positives = 115/266 (43%), Gaps = 31/266 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF-GS 306
            C GG+C N+  +YRC C   F+     + C    E       D  S+  +  +C+   GS
Sbjct: 1293 CDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNEC------DLNSNICMFGECENTKGS 1346

Query: 307  FLCK-----------------------------NGRCIESGSSYECKCNLGFQESSDGKI 399
            F+C                              +  C+    S++C C  G+    +G  
Sbjct: 1347 FICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW--IGNGIK 1404

Query: 400  CSDIDECTTNPTICD-RGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCK 576
            C D+DEC+     C     C+N+PGSY+C+C +GFT      G  C D +EC+E+ +LC+
Sbjct: 1405 CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT----GDGFTCSDVDECAENINLCE 1460

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGT 756
            NG C+N+ G+++C+C  G+  +S+ + C  I + S  +            S  C  + G 
Sbjct: 1461 NGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNIC---------VSGTCNNLPGM 1511

Query: 757  FKCSCPYGMESILDTGLCAPNSQIVD 834
            F C C  G E     G C    +  D
Sbjct: 1512 FHCICDDGYELDRTGGNCTDIDECAD 1537

 Score =  119 bits (297), Expect = 1e-26
 Identities = 56/160 (35%), Positives = 86/160 (53%), Gaps = 1/160 (0%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGT-CINSPGSYQCS 486
            +C NG CI    S+ C+C  GF  +    +C DIDEC+    +C R   CINSPGSY+C 
Sbjct: 1817 ICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCE 1876

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  GF +   P G  C DRNEC E  ++C +G+C+++ GS++C C++G+ AS ++  C+ 
Sbjct: 1877 CAAGFKLS--PNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMD 1933

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
            + +   +   +            C    G++ C C  G E
Sbjct: 1934 VDECERHPCGNGT----------CKNTVGSYNCLCYPGFE 1963

 Score =  115 bits (289), Expect = 1e-25
 Identities = 74/235 (31%), Positives = 101/235 (42%), Gaps = 1/235 (0%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    +RCEC   F  +     C+   E                  C    + 
Sbjct: 1818 CANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDE------------------CSNGDNL 1859

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
              +N  CI S  SY C+C  GF+ S +G  C D +EC   P +C  G C++  GSYQC C
Sbjct: 1860 CQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCIC 1918

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
            ++GF          C D +EC  ++  C NG C N  GS+ C C  G+  + N  DC+ I
Sbjct: 1919 HNGFKASQ--DQTMCMDVDEC--ERHPCGNGTCKNTVGSYNCLCYPGFELTHN-NDCLDI 1973

Query: 670  QD-SSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIV 831
             + SS +  V  N +        C    G+FKC C  G E   D   C   ++ V
Sbjct: 1974 DECSSFFGQVCRNGR--------CFNEIGSFKCLCNEGYELTPDGKNCIDTNECV 2020

 Score =  115 bits (287), Expect = 2e-25
 Identities = 65/206 (31%), Positives = 90/206 (43%), Gaps = 28/206 (13%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+CIN    +RCEC   + LD  G  C    E          +  N+       GSF
Sbjct: 2181 CSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNV------IGSF 2234

Query: 310  LCKNG--------------------------RCIESGSSYECKCNLGFQESSDGKICSDI 411
             C                             RC+ +  SYEC C +G+    D K+C D+
Sbjct: 2235 ECNCNEGFEPGPMMNCEDINECAQNPLLCALRCMNTFGSYECTCPIGYALREDQKMCKDL 2294

Query: 412  DECTTNPTICD-RGT-CINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGV 585
            DEC      C+ RG  C N  G++ C C  G      P G  C D NEC     +C+NG 
Sbjct: 2295 DECAEGLHDCESRGMMCKNLIGTFMCICPPGMA--RRPDGEGCVDENECRTKPGICENGR 2352

Query: 586  CINIHGSFKCQCNSGYVASSNKQDCI 663
            C+NI GS++C+CN G+ +SS+  +C+
Sbjct: 2353 CVNIIGSYRCECNEGFQSSSSGTECL 2378

 Score =  114 bits (285), Expect = 4e-25
 Identities = 76/265 (28%), Positives = 102/265 (38%), Gaps = 51/265 (19%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQAC----KKRTEY-------------------- 237
            C  G CIN +  +RC+C P   +   G+ C     + T Y                    
Sbjct: 667  CMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSE 726

Query: 238  -----------KPNQMNDAASSFNLKSQCDK---------------FGSFLCKNGRCIES 339
                       +P Q   A +S      C                     +C NG C   
Sbjct: 727  CCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENL 786

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMP 519
              SY C CN G++  + G+ C DIDEC  N  +CD G C N+PGSY C+C  G+      
Sbjct: 787  RGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTET 846

Query: 520  GGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVD 699
                C D NEC  + + C NG C N  GSF C+C+ G   SS    CI     + +  + 
Sbjct: 847  --ETCEDINEC--ESNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQ 902

Query: 700  DNSKYCSKCSHYCAFVNG-TFKCSC 771
            D     S+C      +NG T K  C
Sbjct: 903  D-----SRCE---VNINGATLKSEC 919

 Score =  113 bits (282), Expect = 8e-25
 Identities = 70/241 (29%), Positives = 104/241 (43%), Gaps = 23/241 (9%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKK--RTEYKPNQMNDAASSFNL----K 282
            S  C  G C N K  + C C   + + K    C      E   +  +  AS  N+    K
Sbjct: 1332 SNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFK 1391

Query: 283  SQCDKF----------------GSFLCK-NGRCIESGSSYECKCNLGFQESSDGKICSDI 411
              C +                 G+  C  N +C+ +  SY C C+ GF  + DG  CSD+
Sbjct: 1392 CSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF--TGDGFTCSDV 1449

Query: 412  DECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCI 591
            DEC  N  +C+ G C+N PG+Y+C C  GFT         C D +ECS  +++C +G C 
Sbjct: 1450 DECAENINLCENGQCLNVPGAYRCECEMGFT--PASDSRSCQDIDECS-FQNICVSGTCN 1506

Query: 592  NIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
            N+ G F C C+ GY       +C  I + +D           +  +  C    G ++C+C
Sbjct: 1507 NLPGMFHCICDDGYELDRTGGNCTDIDECAD---------PINCVNGLCVNTPGRYECNC 1557

Query: 772  P 774
            P
Sbjct: 1558 P 1558

 Score =  111 bits (277), Expect = 3e-24
 Identities = 82/305 (26%), Positives = 108/305 (35%), Gaps = 88/305 (28%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFNL--KS 285
            C+ GRC+N+   YRCEC   F     G  C          E        A+SS NL  KS
Sbjct: 2348 CENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKS 2407

Query: 286  QCDKFGSF------------------------------------------LCKNGRCIES 339
            +C   G                                            LC NG+CI +
Sbjct: 2408 ECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINT 2467

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIH--- 510
              S+ C C +G+     G  C D+DEC+ +P  C+   C N+ GSYQCSC  G+ +    
Sbjct: 2468 MGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNY-ICKNTEGSYQCSCPRGYVLQEDG 2526

Query: 511  ---------------------NMPGG-------------PKCYDRNECSEDKSLC-KNGV 585
                                 N  GG               C D NEC     LC   G+
Sbjct: 2527 KTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPLLCGGKGI 2586

Query: 586  CINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKC 765
            C N  GSF C+C  G+   +   +C       D    D N     +C H C  + G ++C
Sbjct: 2587 CQNTPGSFSCECQRGFSLDATGLNC------EDVDECDGN----HRCQHGCQNILGGYRC 2636

Query: 766  SCPYG 780
             CP G
Sbjct: 2637 GCPQG 2641

 Score =  106 bits (264), Expect = 1e-22
 Identities = 58/173 (33%), Positives = 87/173 (50%), Gaps = 1/173 (0%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT-NPTICDRGTCINSPGSYQCS 486
            +C NG+CI +  S+ C+C +G+     G  C D DEC+  NP  C  GTC N  GS++C+
Sbjct: 2180 ICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP--CGNGTCTNVIGSFECN 2237

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C +GF    M     C D NEC+++  LC    C+N  GS++C C  GY    +++ C  
Sbjct: 2238 CNEGFEPGPMMN---CEDINECAQNPLLCALR-CMNTFGSYECTCPIGYALREDQKMCKD 2293

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQ 825
            + + ++   + D    C      C  + GTF C CP GM    D   C   ++
Sbjct: 2294 LDECAE--GLHD----CESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENE 2340

 Score =  105 bits (261), Expect = 2e-22
 Identities = 69/239 (28%), Positives = 96/239 (40%), Gaps = 27/239 (11%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK-- 318
            C N +  Y+C C   +VL + G+ CK   E +  Q N      N        G F CK  
Sbjct: 2505 CKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNT------LGGFTCKCP 2558

Query: 319  -------------------------NGRCIESGSSYECKCNLGFQESSDGKICSDIDECT 423
                                      G C  +  S+ C+C  GF   + G  C D+DEC 
Sbjct: 2559 PGFTQHHTACIDNNECGSQPLLCGGKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECD 2618

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
             N   C  G C N  G Y+C C  G+  H      +C D NECS + + C +  C N  G
Sbjct: 2619 GNHR-CQHG-CQNILGGYRCGCPQGYIQHYQ--WNQCVDENECS-NPNACGSASCYNTLG 2673

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            S+KC C SG+        C  + + S       +SK  + C++ C+   G + C CP G
Sbjct: 2674 SYKCACPSGFSFDQFSSACHDVNECS-------SSK--NPCNYGCSNTEGGYLCGCPPG 2723

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 67/251 (26%), Positives = 97/251 (38%), Gaps = 25/251 (9%)
 Frame = +1

Query: 103  CSFSYYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLK 282
            C+   +  + +G  C N+   + C C P       G+ C    E +              
Sbjct: 2297 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPG---------- 2346

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDE----CTTNPTICDRG 450
                     +C+NGRC+    SY C+CN GFQ SS G  C D  +         TIC   
Sbjct: 2347 ---------ICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMA 2397

Query: 451  TCINSPGSYQCSCYDG-------FTIHNMPG----------GPKCY----DRNECSEDKS 567
            +   +  +    C DG         +  +PG          GP       D +EC    +
Sbjct: 2398 SSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPN 2457

Query: 568  LCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFV 747
            LC NG CIN  GSF+C C  GY    +   CI +         D+ S+    C++ C   
Sbjct: 2458 LCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDL---------DECSQSPKPCNYICKNT 2508

Query: 748  NGTFKCSCPYG 780
             G+++CSCP G
Sbjct: 2509 EGSYQCSCPRG 2519

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 64/234 (27%), Positives = 93/234 (39%), Gaps = 16/234 (6%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKK----RTEYKPNQMNDAASSFNLK----- 282
            C  G C+N   +Y C C PDF L+  G  C          K     D + S N +     
Sbjct: 1541 CVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGV 1600

Query: 283  ---SQCDKFGSFL---CKNGRCIESGSSYE-CKCNLGFQESSDGKICSDIDECTTNPTIC 441
               S C   G      C+    + S   Y  C    GF+ +    I  DIDEC   P +C
Sbjct: 1601 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1660

Query: 442  DRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
              G CIN+ GS+QC C  G+ +        C D +EC     +C  G C N  G++ C C
Sbjct: 1661 QGGNCINTFGSFQCECPQGYYLSE--DTRICEDIDECFAHPGVCGPGTCYNTLGNYTCIC 1718

Query: 622  NSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGM 783
               Y+  +   +C+ ++ S  Y + +  +     C +   F      C C Y +
Sbjct: 1719 PPEYMQVNGGHNCMDMRKSFCYRSYNGTT-----CENELPFNVTKRMCCCTYNV 1767

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 56/169 (33%), Positives = 73/169 (43%), Gaps = 1/169 (0%)
 Frame = +1

Query: 130  CKG-GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGS 306
            C G G C N    + CEC   F LD  G  C+   E                  CD  G+
Sbjct: 2581 CGGKGICQNTPGSFSCECQRGFSLDATGLNCEDVDE------------------CD--GN 2620

Query: 307  FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
              C++G C      Y C C  G+ +      C D +EC +NP  C   +C N+ GSY+C+
Sbjct: 2621 HRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENEC-SNPNACGSASCYNTLGSYKCA 2678

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGY 633
            C  GF+         C+D NECS  K+ C  G C N  G + C C  GY
Sbjct: 2679 CPSGFSFDQFSSA--CHDVNECSSSKNPCNYG-CSNTEGGYLCGCPPGY 2724

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 70/256 (27%), Positives = 109/256 (42%), Gaps = 30/256 (11%)
 Frame = +1

Query: 103  CSFSYYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLK 282
            CS S++ + C+ GRC N    ++C C   + L   G+ C    E                
Sbjct: 1976 CS-SFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNE---------------- 2018

Query: 283  SQCDKF-GSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCI 459
              C    GS  C  G C     S+ C C  G++  S+   C DI+EC  +P IC  G+C 
Sbjct: 2019 --CVALPGS--CSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDEDPNICLFGSCT 2072

Query: 460  NSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLC----KNGVCINIHGSF-----K 612
            N+PG +QC C  GF + +   G +C+D  +     S C    +NG C ++  +F     K
Sbjct: 2073 NTPGGFQCLCPPGFVLSD--NGRRCFDTRQ-----SFCFTNFENGKC-SVPKAFNTTKAK 2124

Query: 613  CQCN----SGY---VASSNKQDCISIQDSSDYS-----AVDDNSKYCSKC--------SH 732
            C C+     G+        K D ++ QD   Y      ++ D  +  ++C        + 
Sbjct: 2125 CCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNG 2184

Query: 733  YCAFVNGTFKCSCPYG 780
             C   +G+F+C CP G
Sbjct: 2185 QCINTDGSFRCECPMG 2200

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 66/255 (25%), Positives = 100/255 (39%), Gaps = 28/255 (10%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ G+C+N+   YRCEC   F      ++C         Q  D  S  N+          
Sbjct: 1459 CENGQCLNVPGAYRCECEMGFTPASDSRSC---------QDIDECSFQNI---------- 1499

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C +G C      + C C+ G++    G  C+DIDEC  +P  C  G C+N+PG Y+C+C
Sbjct: 1500 -CVSGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECA-DPINCVNGLCVNTPGRYECNC 1557

Query: 490  YDGFTIHNMPGGPKCYDR--NEC------SEDKSL-CKNGVCINIHGSFKCQCNSGYVAS 642
               F ++  P G  C D     C        D SL C   + + +  S  C C+ G    
Sbjct: 1558 PPDFQLN--PTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRS-SCCCSLGKAWG 1614

Query: 643  SNKQDCISIQDSSDYSAVDDNSKY--------------CSKCSHYCAFVN-----GTFKC 765
            +  + C  +  +  Y+       +              C +    C   N     G+F+C
Sbjct: 1615 NPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQC 1674

Query: 766  SCPYGMESILDTGLC 810
             CP G     DT +C
Sbjct: 1675 ECPQGYYLSEDTRIC 1689

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 62/212 (29%), Positives = 86/212 (40%), Gaps = 13/212 (6%)
 Frame = +1

Query: 100 FCSFSYYSEQCK-GGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKP--NQMNDAASS 270
           +C        C+ GGRCI       C C+  F     G  C++     P   Q+N     
Sbjct: 174 YCGQPVCENGCQNGGRCIAQP----CACVYGFT----GPQCERDYRTGPCFTQVN----- 220

Query: 271 FNLKSQCDKFGSFLCKNGRCIESGSSYECKCNL----------GFQESSDGKICSDIDEC 420
            N   Q    G    K   C  +G ++   C +          GF  +     C D+DEC
Sbjct: 221 -NQMCQGQLTGIVCTKTLCCATTGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDEC 279

Query: 421 TTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIH 600
              P IC  G CIN+ GS++C C  G          KC D +ECS    +C+ G C N  
Sbjct: 280 QAIPGICQGGNCINTVGSFECRCPAGHKQSETT--QKCEDIDECSIIPGICETGECSNTV 337

Query: 601 GSFKCQCNSGYVASSNKQDCISIQDSSDYSAV 696
           GS+ C C  GYV S++   CI  +    +S +
Sbjct: 338 GSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGL 369

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 60/228 (26%), Positives = 95/228 (41%), Gaps = 25/228 (10%)
 Frame = +1

Query: 172  CECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSY 351
            CE  P     +    C     ++PN +       +   +C +    LC+ G CI +  S+
Sbjct: 1617 CETCPPVNSTEYYTLCPGGEGFRPNPITIILEDID---ECQELPG-LCQGGNCINTFGSF 1672

Query: 352  ECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPK 531
            +C+C  G+  S D +IC DIDEC  +P +C  GTC N+ G+Y C C   +   N  GG  
Sbjct: 1673 QCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVN--GGHN 1730

Query: 532  CYDRNEC----SEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQ-DCISIQDSSDYSAV 696
            C D  +     S + + C+N +  N+     C C      + NK  +      ++D+  +
Sbjct: 1731 CMDMRKSFCYRSYNGTTCENELPFNVTKRM-CCCTYNVGKAGNKPCEPCPTPGTADFKTI 1789

Query: 697  DDN---------------SKYCSKCSHYCA---FVN--GTFKCSCPYG 780
              N                  C +    CA    +N  G+F+C CP G
Sbjct: 1790 CGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTG 1837

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 68/279 (24%), Positives = 99/279 (35%), Gaps = 62/279 (22%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N++  YRC C   +  D  G+ C    E   N++                   
Sbjct: 778  CANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRL------------------- 818

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTI--------------CDR 447
            LC NG C  +  SY C C  G+   ++ + C DI+EC +NP +              C  
Sbjct: 819  LCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSP 878

Query: 448  GTCINSPG-----SYQCSCY----DGFTIHNMPG-------------------------- 522
            G+ ++S G     S + +C+    D     N+ G                          
Sbjct: 879  GSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDT 938

Query: 523  ----------GPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQ 672
                      G  C D NEC     +C NG C+N  GSF C+C  G       + C+ I+
Sbjct: 939  ACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIR 998

Query: 673  DSSDYSAVDDNSKYCSKCSHYCAFVNGTFK---CSCPYG 780
                Y   D++     +C H    V G F+   C C  G
Sbjct: 999  MEQCYLKWDED-----ECIHP---VPGKFRMDACCCAVG 1029

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 78/299 (26%), Positives = 105/299 (35%), Gaps = 76/299 (25%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQAC---KKRTEYKPNQMNDAASSFN---LK 282
            S  C  G C N    + CEC P   L   G  C    K T +   Q +    + N   LK
Sbjct: 857  SNPCVNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLK 916

Query: 283  SQC-----DKFGS---------------------------------FLCKNGRCIESGSS 348
            S+C       +GS                                  +C NGRC+ S  S
Sbjct: 917  SECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGS 976

Query: 349  YECKCNLGFQESSDGKICSDI-----------DECT--------TNPTICDRGTCINS-- 465
            + C+C  G      G++C DI           DEC          +   C  G    +  
Sbjct: 977  FHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC 1036

Query: 466  -----PGS--YQCSCYDGFTIHN----MPGGPKCYDRNECSEDKSLCKNGVCINIHGSFK 612
                 PG+  Y+  C  G    N    + G P   D NEC     +C  G C N  GSFK
Sbjct: 1037 EECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFK 1096

Query: 613  CQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMES 789
            C+CNSG+     +++C  I +         +   C   S  C    G+F+C C  G ES
Sbjct: 1097 CRCNSGFALDMEERNCTDIDECR------ISPDLCG--SGICVNTPGSFECECFEGYES 1147

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 60/266 (22%), Positives = 102/266 (38%), Gaps = 30/266 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+GG CIN    ++CEC   + L +  + C+   E   +                     
Sbjct: 1660 CQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPG------------------- 1700

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDEC----TTNPTICDRGTCINSPGSY 477
            +C  G C  +  +Y C C   + + + G  C D+ +     + N T C+     N     
Sbjct: 1701 VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRM 1760

Query: 478  QCSCYDGFTIHNMPGGP--------------------------KCYDRNECSEDKSLCKN 579
             C  Y+     N P  P                          K  D +EC E   +C N
Sbjct: 1761 CCCTYNVGKAGNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICAN 1820

Query: 580  GVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTF 759
            GVCIN  GSF+C+C +G+    +  D + + +  D  +  DN   C + +  C    G++
Sbjct: 1821 GVCINQIGSFRCECPTGF----SYNDLLLVCEDIDECSNGDN--LCQRNAD-CINSPGSY 1873

Query: 760  KCSCPYGMESILDTGLCAPNSQIVDV 837
            +C C  G + +   G C   ++ +++
Sbjct: 1874 RCECAAGFK-LSPNGACVDRNECLEI 1898

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 41/139 (29%), Positives = 64/139 (46%)
 Frame = +1

Query: 409 IDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVC 588
           ID C  +  +C  G CI +  SY+C C  G+          C D +EC+ +   C NG C
Sbjct: 494 IDICKHHANLCLNGRCIPTVSSYRCECNMGY---KQDANGDCIDVDECTSNP--CTNGDC 548

Query: 589 INIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCS 768
           +N  GS+ C+C++G+  +  KQ CI I +      +  N +        C   +G+F+C 
Sbjct: 549 VNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR--------CVNSDGSFQCI 600

Query: 769 CPYGMESILDTGLCAPNSQ 825
           C  G E   D   C  + +
Sbjct: 601 CNAGFELTTDGKNCVDHDE 619

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 51/188 (27%), Positives = 78/188 (41%), Gaps = 22/188 (11%)
 Frame = +1

Query: 313 CKNG-RCIESGSSYECKCNLGF------QESSDGKICSDIDE--CTTNPT--ICDRGTCI 459
           C+NG RCI    +  C C  GF      ++   G   + ++   C    T  +C +  C 
Sbjct: 184 CQNGGRCI----AQPCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCC 239

Query: 460 NSPG---SYQCS--------CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGS 606
            + G    + C         C  GF I N+  G  C D +EC     +C+ G CIN  GS
Sbjct: 240 ATTGRAWGHPCEMCPAQPQPCRRGF-IPNIRTGA-CQDVDECQAIPGICQGGNCINTVGS 297

Query: 607 FKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
           F+C+C +G+  S   Q C  I + S    + +  +        C+   G++ C CP G  
Sbjct: 298 FECRCPAGHKQSETTQKCEDIDECSIIPGICETGE--------CSNTVGSYFCVCPRGYV 349

Query: 787 SILDTGLC 810
           +  D   C
Sbjct: 350 TSTDGSRC 357

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 34/128 (26%), Positives = 51/128 (39%), Gaps = 1/128 (0%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYK-PNQMNDAASSFNLKSQCDK 297
            + +C+ G C N+   YRC C   ++   Q   C    E   PN                 
Sbjct: 2620 NHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA---------------- 2662

Query: 298  FGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSY 477
                 C +  C  +  SY+C C  GF        C D++EC+++   C+ G C N+ G Y
Sbjct: 2663 -----CGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGY 2716

Query: 478  QCSCYDGF 501
             C C  G+
Sbjct: 2717 LCGCPPGY 2724
>sp|Q61555|FBN2_MOUSE Fibrillin-2 precursor
          Length = 2907

 Score =  141 bits (356), Expect = 2e-33
 Identities = 75/232 (32%), Positives = 107/232 (46%)
 Frame = +1

Query: 115  YYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCD 294
            +++  C  GRCI   + YRC C   +  D  G                           D
Sbjct: 493  HHANLCLNGRCIPTVSSYRCRCNMGYKQDANGDCI----------------------DVD 530

Query: 295  KFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGS 474
            +  S  C NG C+ +  SY CKC+ GFQ +   + C DIDEC  N  +C  G C+NS GS
Sbjct: 531  ECTSNPCSNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNSDGS 590

Query: 475  YQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQ 654
            +QC C  GF +     G  C D +EC+   ++C NG+CIN  GSFKC C  G++ + N +
Sbjct: 591  FQCICNAGFEL--TTDGKNCVDHDECT-TTNMCLNGMCINEDGSFKCVCKPGFILAPNGR 647

Query: 655  DCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             C  + D      +  N         +C    G+F+C CP G+   +D  +C
Sbjct: 648  YCTDV-DECQTPGICMNG--------HCINNEGSFRCDCPPGLAVGVDGRVC 690

 Score =  140 bits (353), Expect = 5e-33
 Identities = 78/226 (34%), Positives = 98/226 (43%)
 Frame = +1

Query: 103  CSFSYYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLK 282
            CS S     C+ G+C+NM   Y+C C P +      Q C            D      + 
Sbjct: 1197 CSLS--DNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGC-----------TDIDECMIMN 1243

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCIN 462
              CD          +C  S  SYEC C+ G+    DG+ C+DIDEC  NP ICD G C N
Sbjct: 1244 GGCDT---------QCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTN 1294

Query: 463  SPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
             PG Y+C CYDGF          C D NEC  + ++C  G C N  GSF C C  GY   
Sbjct: 1295 IPGEYRCLCYDGFMA--SMDMKTCIDVNECDLNPNICMFGECENTKGSFICHCQLGYSVK 1352

Query: 643  SNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
                 C      +D    +  +  C   +  C  V G+FKCSC  G
Sbjct: 1353 KGTTGC------TDVDECEIGAHNCDMHAS-CLNVPGSFKCSCREG 1391

 Score =  138 bits (348), Expect = 2e-32
 Identities = 74/229 (32%), Positives = 107/229 (46%), Gaps = 1/229 (0%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C N    ++C C   F LD + + C    E +                       
Sbjct: 1077 CTYGKCRNTIGSFKCRCNNGFALDMEERNCTDIDECR-------------------ISPD 1117

Query: 310  LCKNGRCIESGSSYECKCNLGFQES-SDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
            LC +G C+ +  S+EC+C  G++      K C DIDEC  NP +C  GTC+N+ GS+QC 
Sbjct: 1118 LCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCD 1177

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  G  +   P    C D NECS   +LC+NG C+N+ G+++C CN GY A+ ++Q C  
Sbjct: 1178 CPLGHELS--PSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTD 1235

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCA 813
            I         D+       C   C    G+++CSC  G   + D   CA
Sbjct: 1236 I---------DECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSCA 1275

 Score =  131 bits (330), Expect = 2e-30
 Identities = 60/176 (34%), Positives = 97/176 (55%)
 Frame = +1

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCIN 462
            ++C  F   +C  G+C  +  S++C+CN GF    + + C+DIDEC  +P +C  G C+N
Sbjct: 1068 NECKAFPG-MCTYGKCRNTIGSFKCRCNNGFALDMEERNCTDIDECRISPDLCGSGICVN 1126

Query: 463  SPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
            +PGS++C C++G+    M     C D +EC  +  LC+ G C+N  GSF+C C  G+  S
Sbjct: 1127 TPGSFECECFEGYESGFMM-MKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELS 1185

Query: 643  SNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             +++DC+ I + S    +  N K        C  + GT++CSC  G ++  D   C
Sbjct: 1186 PSREDCVDINECSLSDNLCRNGK--------CVNMIGTYQCSCNPGYQATPDRQGC 1233

 Score =  131 bits (329), Expect = 3e-30
 Identities = 71/214 (33%), Positives = 95/214 (44%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N    Y C C P F L                  ND         +C  F   
Sbjct: 1936 CANGTCKNTVGSYNCLCYPGFELTHN---------------NDCLDI----DECSSFFGQ 1976

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +C+NGRC     S++C CN G++ + DGK C D +EC   P  C  GTC N  GS++C C
Sbjct: 1977 VCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCIC 2036

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
              G+ + +      C D NEC ED ++C  G C N  G F+C C  G+V S N + C   
Sbjct: 2037 PPGYEVRS----ENCIDINECDEDPNICLFGSCTNTPGGFQCICPPGFVLSDNGRRCFDT 2092

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
            + S  ++  ++      KCS   AF     KC C
Sbjct: 2093 RQSFCFTNFEN-----GKCSVPKAFNTTKAKCCC 2121

 Score =  122 bits (305), Expect = 2e-27
 Identities = 57/160 (35%), Positives = 86/160 (53%), Gaps = 1/160 (0%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGT-CINSPGSYQCS 486
            +C NG CI    S+ C+C  GF  +    +C DIDEC+    +C R   CINSPGSY+C 
Sbjct: 1811 ICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCE 1870

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  GF +   P G  C DRNEC E  ++C +G+C+++ GS++C CN+G+ AS ++  C+ 
Sbjct: 1871 CAAGFKLS--PNGA-CVDRNECLEIPNVCSHGLCVDLQGSYQCICNNGFKASQDQTMCMD 1927

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
            + +   +   +            C    G++ C C  G E
Sbjct: 1928 VDECERHPCANGT----------CKNTVGSYNCLCYPGFE 1957

 Score =  116 bits (290), Expect = 9e-26
 Identities = 82/305 (26%), Positives = 111/305 (36%), Gaps = 88/305 (28%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFNL--KS 285
            C+ GRC+N+   YRCEC   F     G  C          E        A+SS NL  KS
Sbjct: 2342 CENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTMCQMASSSRNLVTKS 2401

Query: 286  QCDKFGS------------------------------------------FLCKNGRCIES 339
            +C   G                                            LC NG+C+ +
Sbjct: 2402 ECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYATDGRDIDECKVMPSLCTNGQCVNT 2461

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIH--- 510
              S+ C C +G+     G  C D+DEC+ +P  C+   C N+ GSYQCSC  G+ +    
Sbjct: 2462 MGSFRCFCKVGYTMDISGTACVDLDECSQSPKPCN-FICKNTKGSYQCSCPRGYVLQEDG 2520

Query: 511  ---------------------NMPGG-------------PKCYDRNECSEDKSLC-KNGV 585
                                 N  GG               C D NEC    SLC   G+
Sbjct: 2521 KTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGI 2580

Query: 586  CINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKC 765
            C N  GSF C+C  G+   ++  +C       D    D N     +C H C  + G ++C
Sbjct: 2581 CQNTPGSFSCECQRGFSLDASGLNC------EDVDECDGN----HRCQHGCQNILGGYRC 2630

Query: 766  SCPYG 780
             CP+G
Sbjct: 2631 GCPHG 2635

 Score =  115 bits (288), Expect = 2e-25
 Identities = 80/262 (30%), Positives = 108/262 (41%), Gaps = 43/262 (16%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    +RCEC   F  +     C+   E                  C    + 
Sbjct: 1812 CANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDE------------------CSNGDNL 1853

Query: 310  LCKNGRCIESGSSYECKC-----------------------------------------N 366
              +N  CI S  SY C+C                                         N
Sbjct: 1854 CQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICN 1913

Query: 367  LGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTI-HNMPGGPKCYDR 543
             GF+ S D  +C D+DEC  +P  C  GTC N+ GSY C CY GF + HN      C D 
Sbjct: 1914 NGFKASQDQTMCMDVDECERHP--CANGTCKNTVGSYNCLCYPGFELTHN----NDCLDI 1967

Query: 544  NECSE-DKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCS 720
            +ECS     +C+NG C N  GSFKC CN GY  + + ++CI   D+++  A+  +   CS
Sbjct: 1968 DECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI---DTNECVALPGS---CS 2021

Query: 721  KCSHYCAFVNGTFKCSCPYGME 786
              +  C  + G+F+C CP G E
Sbjct: 2022 PGT--CQNLEGSFRCICPPGYE 2041

 Score =  114 bits (284), Expect = 5e-25
 Identities = 74/269 (27%), Positives = 103/269 (38%), Gaps = 55/269 (20%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQAC----KKRTEY-------------------- 237
            C  G CIN +  +RC+C P   +   G+ C     + T Y                    
Sbjct: 661  CMNGHCINNEGSFRCDCPPGLAVGVDGRVCVDTHMRSTCYGEIKKGVCVRPFPGAVTKSE 720

Query: 238  -----------KPNQMNDAASSFNLKSQCDK---------------FGSFLCKNGRCIES 339
                       +P Q   A +S      C                     +C NG C   
Sbjct: 721  CCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGIGITVDGRDINECALDPDICANGICENL 780

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMP 519
              +Y C CN G++  + G+ C DIDEC  N  +CD G C N+PGSY C+C  G+ +    
Sbjct: 781  RGTYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVLPTET 840

Query: 520  GGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVD 699
                C D NEC  + + C NG C N  GSF C+C+ G   SS    CI     + +  + 
Sbjct: 841  --ETCEDVNEC--ESNPCVNGACRNNLGSFHCECSPGSKLSSTGLICIDSLKGTCWLNIQ 896

Query: 700  DNS-----KYCSKCSHYCAFVNGTFKCSC 771
            DN         +  S  CA + G +   C
Sbjct: 897  DNRCEVNINGATLKSECCATLGGAWGSPC 925

 Score =  113 bits (282), Expect = 8e-25
 Identities = 64/201 (31%), Positives = 90/201 (44%), Gaps = 23/201 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNL---------- 279
            C  G+CIN    +RCEC   + LD  G  C    E          +  N+          
Sbjct: 2175 CSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGCFECTCNE 2234

Query: 280  ------KSQCDKFGS-----FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT 426
                     C+          LC   RC+ +  SYEC C +G+    D K+C D+DEC  
Sbjct: 2235 GFEPGPMMNCEDINECAQNPLLCAF-RCMNTFGSYECTCPVGYGLREDQKMCKDLDECAE 2293

Query: 427  NPTICD-RGT-CINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIH 600
                C+ RG  C N  G++ C C  G      P G  C D NEC     +C+NG C+NI 
Sbjct: 2294 GLHDCESRGMMCKNLIGTFMCICPPGMA--RRPDGEGCVDENECRTKPGICENGRCVNII 2351

Query: 601  GSFKCQCNSGYVASSNKQDCI 663
            GS++C+CN G+ +SS+  +C+
Sbjct: 2352 GSYRCECNEGFQSSSSGTECL 2372

 Score =  111 bits (278), Expect = 2e-24
 Identities = 69/238 (28%), Positives = 102/238 (42%), Gaps = 23/238 (9%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKK--RTEYKPNQMNDAASSFNL----KSQC 291
            C  G C N K  + C C   + + K    C      E   +  +  AS  N+    K  C
Sbjct: 1329 CMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNVPGSFKCSC 1388

Query: 292  DKF----------------GSFLCK-NGRCIESGSSYECKCNLGFQESSDGKICSDIDEC 420
             +                 G+  C  N +C+ +  SY C C+ GF  + DG  CSD+DEC
Sbjct: 1389 REGWVGNGIKCIDLDECANGTHQCSINAQCVNTPGSYRCACSEGF--TGDGFTCSDVDEC 1446

Query: 421  TTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIH 600
              N  +C+ G C+N PG+Y+C C  GFT         C D +ECS  +++C  G C N+ 
Sbjct: 1447 AENTNLCENGQCLNVPGAYRCECEMGFT--PASDSRSCQDIDECS-FQNICVFGTCNNLP 1503

Query: 601  GSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCP 774
            G F C C+ GY       +C  I + +D           +  +  C    G ++C+CP
Sbjct: 1504 GMFHCICDDGYELDRTGGNCTDIDECAD---------PINCVNGLCVNTPGRYECNCP 1552

 Score =  108 bits (269), Expect = 3e-23
 Identities = 70/233 (30%), Positives = 96/233 (41%), Gaps = 21/233 (9%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMN------DAASSFNLK-------- 282
            C N K  Y+C C   +VL + G+ CK   E +  Q N      +    F  K        
Sbjct: 2499 CKNTKGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQH 2558

Query: 283  -------SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTIC 441
                   ++C    S     G C  +  S+ C+C  GF   + G  C D+DEC  N   C
Sbjct: 2559 HTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDASGLNCEDVDECDGNHR-C 2617

Query: 442  DRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
              G C N  G Y+C C  G   H      +C D NECS +   C +  C N  GS+KC C
Sbjct: 2618 QHG-CQNILGGYRCGCPHGDVQHYQ--WNQCVDENECS-NPGACGSASCYNTLGSYKCAC 2673

Query: 622  NSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             SG+        C  + + S       +SK  + CS+ C+   G + C CP G
Sbjct: 2674 PSGFSFDQFSSACHDVNECS-------SSK--NPCSYGCSNTEGGYLCGCPPG 2717

 Score =  105 bits (262), Expect = 2e-22
 Identities = 70/255 (27%), Positives = 103/255 (40%), Gaps = 25/255 (9%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF 300
            +  C  G CIN    ++C C P F+L   G+ C    E                  C   
Sbjct: 617  TNMCLNGMCINEDGSFKCVCKPGFILAPNGRYCTDVDE------------------CQTP 658

Query: 301  GSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINS-PGSY 477
            G  +C NG CI +  S+ C C  G     DG++C D    +T      +G C+   PG+ 
Sbjct: 659  G--ICMNGHCINNEGSFRCDCPPGLAVGVDGRVCVDTHMRSTCYGEIKKGVCVRPFPGAV 716

Query: 478  ---QCSCYD---GFTIHNMPGGPK--------CY----------DRNECSEDKSLCKNGV 585
               +C C +   GF     P   K        C           D NEC+ D  +C NG+
Sbjct: 717  TKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGIGITVDGRDINECALDPDICANGI 776

Query: 586  CINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKC 765
            C N+ G+++C CNSGY   ++ ++CI I +      + DN          C    G++ C
Sbjct: 777  CENLRGTYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG--------LCRNTPGSYSC 828

Query: 766  SCPYGMESILDTGLC 810
            +CP G     +T  C
Sbjct: 829  TCPPGYVLPTETETC 843

 Score =  103 bits (256), Expect = 8e-22
 Identities = 57/173 (32%), Positives = 86/173 (49%), Gaps = 1/173 (0%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT-NPTICDRGTCINSPGSYQCS 486
            +C NG+CI +  S+ C+C +G+     G  C D DEC+  NP  C  GTC N  G ++C+
Sbjct: 2174 ICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP--CGNGTCTNVIGCFECT 2231

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C +GF    M     C D NEC+++  LC    C+N  GS++C C  GY    +++ C  
Sbjct: 2232 CNEGFEPGPMMN---CEDINECAQNPLLCAFR-CMNTFGSYECTCPVGYGLREDQKMCKD 2287

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQ 825
            + + ++   + D    C      C  + GTF C CP GM    D   C   ++
Sbjct: 2288 LDECAE--GLHD----CESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENE 2334

 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 62/251 (24%), Positives = 92/251 (36%), Gaps = 25/251 (9%)
 Frame = +1

Query: 103  CSFSYYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLK 282
            C+   +  + +G  C N+   + C C P       G+ C    E +              
Sbjct: 2291 CAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPG---------- 2340

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSD--------------IDEC 420
                     +C+NGRC+    SY C+CN GFQ SS G  C D                  
Sbjct: 2341 ---------ICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTMCQMA 2391

Query: 421  TTNPTICDRGTCINSPG---SYQCSC--------YDGFTIHNMPGGPKCYDRNECSEDKS 567
            +++  +  +  C    G    +QC          Y     H         D +EC    S
Sbjct: 2392 SSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYATDGRDIDECKVMPS 2451

Query: 568  LCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFV 747
            LC NG C+N  GSF+C C  GY    +   C+ +         D+ S+    C+  C   
Sbjct: 2452 LCTNGQCVNTMGSFRCFCKVGYTMDISGTACVDL---------DECSQSPKPCNFICKNT 2502

Query: 748  NGTFKCSCPYG 780
             G+++CSCP G
Sbjct: 2503 KGSYQCSCPRG 2513

 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 62/234 (26%), Positives = 93/234 (39%), Gaps = 16/234 (6%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQAC------------KKRTEYKPNQMNDAASSF 273
            C  G C+N   +Y C C PDF L+  G  C              R +   +   +A    
Sbjct: 1535 CVNGLCVNTPGRYECNCPPDFQLNATGVGCVDNRVGNCYLKFGPRGDGSLSCNTEAGVGV 1594

Query: 274  NLKSQCDKFGSFL---CKNGRCIESGSSYE-CKCNLGFQESSDGKICSDIDECTTNPTIC 441
            +  S C   G      C+    + S   Y  C    GF+ +    I  DIDEC   P +C
Sbjct: 1595 SRSSCCCSLGKAWGNPCETCPPVNSTEHYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1654

Query: 442  DRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
              G CIN+ GS+QC C  G+ +        C D +EC     +C  G C N  G++ C C
Sbjct: 1655 QGGNCINTFGSFQCECPQGYYLSEET--RICEDIDECFAHPGVCGPGTCYNTLGNYTCIC 1712

Query: 622  NSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGM 783
               Y+  +   +C+ ++ S  Y + +  +     C +   F      C C Y +
Sbjct: 1713 PPEYMQVNGGHNCMDMRKSFCYRSYNGTT-----CENELPFNVTKRMCCCTYNV 1761

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 70/256 (27%), Positives = 109/256 (42%), Gaps = 30/256 (11%)
 Frame = +1

Query: 103  CSFSYYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLK 282
            CS S++ + C+ GRC N    ++C C   + L   G+ C    E                
Sbjct: 1970 CS-SFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNE---------------- 2012

Query: 283  SQCDKF-GSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCI 459
              C    GS  C  G C     S+ C C  G++  S+   C DI+EC  +P IC  G+C 
Sbjct: 2013 --CVALPGS--CSPGTCQNLEGSFRCICPPGYEVRSEN--CIDINECDEDPNICLFGSCT 2066

Query: 460  NSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLC----KNGVCINIHGSF-----K 612
            N+PG +QC C  GF + +   G +C+D  +     S C    +NG C ++  +F     K
Sbjct: 2067 NTPGGFQCICPPGFVLSD--NGRRCFDTRQ-----SFCFTNFENGKC-SVPKAFNTTKAK 2118

Query: 613  CQCN----SGY---VASSNKQDCISIQDSSDYS-----AVDDNSKYCSKC--------SH 732
            C C+     G+        K D ++ QD   Y      ++ D  +  ++C        + 
Sbjct: 2119 CCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNG 2178

Query: 733  YCAFVNGTFKCSCPYG 780
             C   +G+F+C CP G
Sbjct: 2179 QCINTDGSFRCECPMG 2194

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 65/215 (30%), Positives = 87/215 (40%), Gaps = 7/215 (3%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C N    + CEC   F LD  G  C+   E                  CD  G+  C+
Sbjct: 2579 GICQNTPGSFSCECQRGFSLDASGLNCEDVDE------------------CD--GNHRCQ 2618

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C      Y C C  G  +      C D +EC +NP  C   +C N+ GSY+C+C  G
Sbjct: 2619 HG-CQNILGGYRCGCPHGDVQHYQWNQCVDENEC-SNPGACGSASCYNTLGSYKCACPSG 2676

Query: 499  FTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQD- 675
            F+         C+D NECS  K+ C  G C N  G + C C  GY     +  C+S    
Sbjct: 2677 FSFDQFSSA--CHDVNECSSSKNPCSYG-CSNTEGGYLCGCPPGYF-RVGQGHCVSGMGF 2732

Query: 676  ------SSDYSAVDDNSKYCSKCSHYCAFVNGTFK 762
                  S D  A DD +    +  + C  +NG  K
Sbjct: 2733 NKGQYLSVDAEAEDDENALSPEACYECK-INGYTK 2766

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 79/299 (26%), Positives = 106/299 (35%), Gaps = 76/299 (25%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQAC---KKRTEYKPNQMNDAASSFN---LK 282
            S  C  G C N    + CEC P   L   G  C    K T +   Q N    + N   LK
Sbjct: 851  SNPCVNGACRNNLGSFHCECSPGSKLSSTGLICIDSLKGTCWLNIQDNRCEVNINGATLK 910

Query: 283  SQC-----DKFGS---------------------------------FLCKNGRCIESGSS 348
            S+C       +GS                                  +C NGRC+ S  S
Sbjct: 911  SECCATLGGAWGSPCERCELDAACPRGFARIKGVTCEDVNECEVFPGVCPNGRCVNSKGS 970

Query: 349  YECKCNLGFQESSDGKICSDI-----------DECT--------TNPTICDRGTCINS-- 465
            + C+C  G      G++C DI           DEC          +   C  G    +  
Sbjct: 971  FHCECPEGLTLDGTGRVCLDIRMEHCFLKWDEDECIHPVPGKFRMDACCCAVGAAWGTEC 1030

Query: 466  -----PGS--YQCSCYDGFTIHN----MPGGPKCYDRNECSEDKSLCKNGVCINIHGSFK 612
                 PG+  Y+  C  G    N    + G P C D NEC     +C  G C N  GSFK
Sbjct: 1031 EECPKPGTKEYETLCPRGPGFANRGDILTGRPFCKDINECKAFPGMCTYGKCRNTIGSFK 1090

Query: 613  CQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMES 789
            C+CN+G+     +++C  I +         +   C   S  C    G+F+C C  G ES
Sbjct: 1091 CRCNNGFALDMEERNCTDIDECR------ISPDLCG--SGICVNTPGSFECECFEGYES 1141

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 63/253 (24%), Positives = 97/253 (38%), Gaps = 26/253 (10%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ G+C+N+   YRCEC   F      ++C         Q  D  S  N+          
Sbjct: 1453 CENGQCLNVPGAYRCECEMGFTPASDSRSC---------QDIDECSFQNI---------- 1493

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C  G C      + C C+ G++    G  C+DIDEC  +P  C  G C+N+PG Y+C+C
Sbjct: 1494 -CVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECA-DPINCVNGLCVNTPGRYECNC 1551

Query: 490  YDGFTIHNMPGG------PKCYDRNECSEDKSL-CKNGVCINIHGSFKCQCNSGYVASSN 648
               F ++    G        CY +     D SL C     + +  S  C C+ G    + 
Sbjct: 1552 PPDFQLNATGVGCVDNRVGNCYLKFGPRGDGSLSCNTEAGVGVSRS-SCCCSLGKAWGNP 1610

Query: 649  KQDCISIQDSSDYSAVDDNSKY--------------CSKCSHYCAFVN-----GTFKCSC 771
             + C  +  +  Y+       +              C +    C   N     G+F+C C
Sbjct: 1611 CETCPPVNSTEHYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCEC 1670

Query: 772  PYGMESILDTGLC 810
            P G     +T +C
Sbjct: 1671 PQGYYLSEETRIC 1683

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 61/208 (29%), Positives = 87/208 (41%), Gaps = 9/208 (4%)
 Frame = +1

Query: 100 FCSFSYYSEQCK-GGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKP--NQMNDAASS 270
           +C        C+ GGRCI      RC C+  F     G  C++     P   Q+N+    
Sbjct: 174 YCGQPVCENGCQNGGRCIGPN---RCACVYGFT----GPQCERDYRTGPCFTQVNNQMCQ 226

Query: 271 FNLKS-QCDKFGSFLCKN-----GRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNP 432
             L    C K  +  C       G   E   +    C  GF  +     C D+DEC   P
Sbjct: 227 GQLTGIVCTK--TLCCATIGRAWGHPCEMCPAQPQPCRPGFIPNIRTGACQDVDECQAIP 284

Query: 433 TICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFK 612
            +C  G CIN+ GS++C C  G          KC D +ECS    +C+ G C N  GS+ 
Sbjct: 285 GLCQGGNCINTVGSFECRCPAGHKQSETT--QKCEDIDECSVIPGVCETGDCSNTVGSYF 342

Query: 613 CQCNSGYVASSNKQDCISIQDSSDYSAV 696
           C C  G+V S++   CI  +  + +S +
Sbjct: 343 CLCPRGFVTSTDGSRCIDQRAGTCFSGL 370

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 59/228 (25%), Positives = 95/228 (41%), Gaps = 25/228 (10%)
 Frame = +1

Query: 172  CECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSY 351
            CE  P     +    C     ++PN +       +   +C +    LC+ G CI +  S+
Sbjct: 1611 CETCPPVNSTEHYTLCPGGEGFRPNPITIILEDID---ECQELPG-LCQGGNCINTFGSF 1666

Query: 352  ECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPK 531
            +C+C  G+  S + +IC DIDEC  +P +C  GTC N+ G+Y C C   +   N  GG  
Sbjct: 1667 QCECPQGYYLSEETRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVN--GGHN 1724

Query: 532  CYDRNEC----SEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQ-DCISIQDSSDYSAV 696
            C D  +     S + + C+N +  N+     C C      + NK  +      ++D+  +
Sbjct: 1725 CMDMRKSFCYRSYNGTTCENELPFNVTKRM-CCCTYNVGKAGNKPCEPCPTPGTADFKTI 1783

Query: 697  DDN---------------SKYCSKCSHYCA---FVN--GTFKCSCPYG 780
              N                  C +    CA    +N  G+F+C CP G
Sbjct: 1784 CGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTG 1831

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 70/281 (24%), Positives = 96/281 (34%), Gaps = 64/281 (22%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N++  YRC C   +  D  G+ C    E   N++                   
Sbjct: 772  CANGICENLRGTYRCNCNSGYEPDASGRNCIDIDECLVNRL------------------- 812

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCIN--------- 462
            LC NG C  +  SY C C  G+   ++ + C D++EC +NP  C  G C N         
Sbjct: 813  LCDNGLCRNTPGSYSCTCPPGYVLPTETETCEDVNECESNP--CVNGACRNNLGSFHCEC 870

Query: 463  SPGSYQCS----CYDGF----------------------------TIHNMPGGP------ 528
            SPGS   S    C D                              T+    G P      
Sbjct: 871  SPGSKLSSTGLICIDSLKGTCWLNIQDNRCEVNINGATLKSECCATLGGAWGSPCERCEL 930

Query: 529  --------------KCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
                           C D NEC     +C NG C+N  GSF C+C  G       + C+ 
Sbjct: 931  DAACPRGFARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLD 990

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFK---CSCPYG 780
            I+    +   D++     +C H    V G F+   C C  G
Sbjct: 991  IRMEHCFLKWDED-----ECIHP---VPGKFRMDACCCAVG 1023

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 60/266 (22%), Positives = 103/266 (38%), Gaps = 30/266 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+GG CIN    ++CEC   + L ++ + C+   E   +                     
Sbjct: 1654 CQGGNCINTFGSFQCECPQGYYLSEETRICEDIDECFAHPG------------------- 1694

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDEC----TTNPTICDRGTCINSPGSY 477
            +C  G C  +  +Y C C   + + + G  C D+ +     + N T C+     N     
Sbjct: 1695 VCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRM 1754

Query: 478  QCSCYDGFTIHNMPGGP--------------------------KCYDRNECSEDKSLCKN 579
             C  Y+     N P  P                          K  D +EC E   +C N
Sbjct: 1755 CCCTYNVGKAGNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICAN 1814

Query: 580  GVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTF 759
            GVCIN  GSF+C+C +G+    +  D + + +  D  +  DN   C + +  C    G++
Sbjct: 1815 GVCINQIGSFRCECPTGF----SYNDLLLVCEDIDECSNGDN--LCQRNAD-CINSPGSY 1867

Query: 760  KCSCPYGMESILDTGLCAPNSQIVDV 837
            +C C  G + +   G C   ++ +++
Sbjct: 1868 RCECAAGFK-LSPNGACVDRNECLEI 1892

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 41/139 (29%), Positives = 64/139 (46%)
 Frame = +1

Query: 409 IDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVC 588
           ID C  +  +C  G CI +  SY+C C  G+          C D +EC+ +   C NG C
Sbjct: 488 IDICKHHANLCLNGRCIPTVSSYRCRCNMGY---KQDANGDCIDVDECTSNP--CSNGDC 542

Query: 589 INIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCS 768
           +N  GS+ C+C++G+  +  KQ CI I +      +  N +        C   +G+F+C 
Sbjct: 543 VNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR--------CVNSDGSFQCI 594

Query: 769 CPYGMESILDTGLCAPNSQ 825
           C  G E   D   C  + +
Sbjct: 595 CNAGFELTTDGKNCVDHDE 613

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 53/188 (28%), Positives = 76/188 (40%), Gaps = 22/188 (11%)
 Frame = +1

Query: 313 CKNG-RCIESGSSYECKCNLGF------QESSDGKICSDIDE--CTTNPT--ICDRGTCI 459
           C+NG RCI       C C  GF      ++   G   + ++   C    T  +C +  C 
Sbjct: 184 CQNGGRCIGPN---RCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCC 240

Query: 460 NSPG---SYQCS--------CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGS 606
            + G    + C         C  GF I N+  G  C D +EC     LC+ G CIN  GS
Sbjct: 241 ATIGRAWGHPCEMCPAQPQPCRPGF-IPNIRTGA-CQDVDECQAIPGLCQGGNCINTVGS 298

Query: 607 FKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
           F+C+C +G+  S   Q C  I + S    V +           C+   G++ C CP G  
Sbjct: 299 FECRCPAGHKQSETTQKCEDIDECSVIPGVCETGD--------CSNTVGSYFCLCPRGFV 350

Query: 787 SILDTGLC 810
           +  D   C
Sbjct: 351 TSTDGSRC 358

 Score = 32.0 bits (71), Expect = 2.4
 Identities = 24/92 (26%), Positives = 34/92 (36%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C    C N    Y+C C   F  D+   AC        + +N+ +SS   K+ C    S+
Sbjct: 2657 CGSASCYNTLGSYKCACPSGFSFDQFSSAC--------HDVNECSSS---KNPC----SY 2701

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICS 405
             C N     +   Y C C  G+     G   S
Sbjct: 2702 GCSN-----TEGGYLCGCPPGYFRVGQGHCVS 2728
>sp|P35555|FBN1_HUMAN Fibrillin-1 precursor
          Length = 2871

 Score =  139 bits (350), Expect = 1e-32
 Identities = 84/239 (35%), Positives = 102/239 (42%), Gaps = 22/239 (9%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYK------PN------------QMN 255
            C+GG C N +  YRCEC P   L     AC    E +      PN              N
Sbjct: 1124 CRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACN 1183

Query: 256  DAASSFNLKSQCDKFGSFLCKNGRC----IESGSSYECKCNLGFQESSDGKICSDIDECT 423
                S   +  C         NG C      S  SYEC C  GF    D + C+DIDEC 
Sbjct: 1184 PGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECE 1243

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
             NP ICD G C N PG Y+C CYDGF          C D NEC  + ++C +G C N  G
Sbjct: 1244 DNPNICDGGQCTNIPGEYRCLCYDGFMASE--DMKTCVDVNECDLNPNICLSGTCENTKG 1301

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            SF C C+ GY     K  C      +D +  +  +  C K +  C    G+FKCSC  G
Sbjct: 1302 SFICHCDMGYSGKKGKTGC------TDINECEIGAHNCGKHA-VCTNTAGSFKCSCSPG 1353

 Score =  136 bits (343), Expect = 7e-32
 Identities = 77/227 (33%), Positives = 108/227 (47%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ GRCI     YRCEC   F LD +G+                        +C+K    
Sbjct: 460  CQNGRCIPTPGSYRCECNKGFQLDLRGECIDV-------------------DECEKNP-- 498

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C  G CI +  SY C+C  G+Q +     C DIDEC  N  IC+ G CIN+ GS+ C C
Sbjct: 499  -CAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVC 557

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
              GF  H    G  C D +ECS  +++C NG+CIN  GSFKC C  G+  +S+ + C  I
Sbjct: 558  NAGF--HVTRDGKNCEDMDECS-IRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDI 614

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             +  +   +  N +        C   +G+++C C  G+   LD  +C
Sbjct: 615  NE-CETPGICMNGR--------CVNTDGSYRCECFPGLAVGLDGRVC 652

 Score =  133 bits (335), Expect = 6e-31
 Identities = 76/242 (31%), Positives = 122/242 (50%), Gaps = 25/242 (10%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLD------------KQGQACKK-----------RTEYK 240
            C+ G CINM   +RCEC   F  +            + G  C++           R + K
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCK 1836

Query: 241  PNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDEC 420
            P     +    N +++C +  + +C +G+CI++  S+ C C+ GF+ + D  +C DI+EC
Sbjct: 1837 PGYRFTSTGQCNDRNECQEIPN-ICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINEC 1895

Query: 421  TTNPTICDRGTCINSPGSYQCSCYDGFTI-HNMPGGPKCYDRNEC-SEDKSLCKNGVCIN 594
              +   C  GTC N+ GS+ C C  GF + HN      C D +EC S + +LC+NG CIN
Sbjct: 1896 ERDA--CGNGTCRNTIGSFNCRCNHGFILSHNND----CIDVDECASGNGNLCRNGQCIN 1949

Query: 595  IHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCP 774
              GSF+CQCN GY  + + + C+ I +           + C+  +  C  ++G+++C CP
Sbjct: 1950 TVGSFQCQCNEGYEVAPDGRTCVDINECLL------EPRKCAPGT--CQNLDGSYRCICP 2001

Query: 775  YG 780
             G
Sbjct: 2002 PG 2003

 Score =  131 bits (330), Expect = 2e-30
 Identities = 73/242 (30%), Positives = 105/242 (43%), Gaps = 7/242 (2%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C N    ++C C   F LD + + C    E +                       
Sbjct: 1039 CTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECR-------------------ISPD 1079

Query: 310  LCKNGRCIESGSSYECKCNLGFQES-SDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
            LC  G+C+ +   +ECKC+ G++      K C DIDEC  +P +C  G C N+ GSY+C 
Sbjct: 1080 LCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCE 1139

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  G  +   P    C D NEC     LC NG C+N+ G ++C CN GY ++ ++  C+ 
Sbjct: 1140 CPPGHQLS--PNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVD 1197

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG------MESILDTGLCAPNSQI 828
            I         D+ S     C  +C    G+++CSC  G        S  D   C  N  I
Sbjct: 1198 I---------DECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNI 1248

Query: 829  VD 834
             D
Sbjct: 1249 CD 1250

 Score =  129 bits (324), Expect = 1e-29
 Identities = 69/216 (31%), Positives = 101/216 (46%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFG 303
            + C  G C N    + C C   F+L                  ND         +C    
Sbjct: 1898 DACGNGTCRNTIGSFNCRCNHGFILSHN---------------NDCIDV----DECASGN 1938

Query: 304  SFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQC 483
              LC+NG+CI +  S++C+CN G++ + DG+ C DI+EC   P  C  GTC N  GSY+C
Sbjct: 1939 GNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSYRC 1998

Query: 484  SCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCI 663
             C  G+++ N     KC D +EC E+  +C  G C N  GSFKC C  G+  SS+ + C 
Sbjct: 1999 ICPPGYSLQN----EKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQ 2054

Query: 664  SIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
             ++ S  Y+  +       KCS   +  +   +C C
Sbjct: 2055 DLRMSYCYAKFEG-----GKCSSPKSRNHSKQECCC 2085

 Score =  129 bits (323), Expect = 1e-29
 Identities = 65/213 (30%), Positives = 106/213 (49%)
 Frame = +1

Query: 172  CECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSY 351
            CE  P     +  + C +   +   ++ +    F   ++C    S LC +G+C  +  S+
Sbjct: 993  CEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPS-LCTHGKCRNTIGSF 1051

Query: 352  ECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPK 531
            +C+C+ GF   S+ + C+DIDEC  +P +C RG C+N+PG ++C C +G+    M     
Sbjct: 1052 KCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMM-MKN 1110

Query: 532  CYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSK 711
            C D +EC  D  LC+ GVC N  GS++C+C  G+  S N   CI I +    + +  N +
Sbjct: 1111 CMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGR 1170

Query: 712  YCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
                    C  + G ++C+C  G  S  D   C
Sbjct: 1171 --------CVNLIGKYQCACNPGYHSTPDRLFC 1195

 Score =  120 bits (302), Expect = 4e-27
 Identities = 77/279 (27%), Positives = 120/279 (43%), Gaps = 36/279 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF-GS 306
            C GG+C N+  +YRC C   F+  +  + C    E       D   +  L   C+   GS
Sbjct: 1249 CDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNEC------DLNPNICLSGTCENTKGS 1302

Query: 307  FLC-----------------------------KNGRCIESGSSYECKCNLGFQESSDGKI 399
            F+C                             K+  C  +  S++C C+ G+    DG  
Sbjct: 1303 FICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW--IGDGIK 1360

Query: 400  CSDIDECTTNPTICDR-GTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCK 576
            C+D+DEC+    +C +   C N+ GSY+C C +G+T      G  C D +ECSE+ +LC 
Sbjct: 1361 CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT----GDGFTCTDLDECSENLNLCG 1416

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAF---- 744
            NG C+N  G ++C+C+ G+V S++ + C  I + S                + C F    
Sbjct: 1417 NGQCLNAPGGYRCECDMGFVPSADGKACEDIDECS--------------LPNICVFGTCH 1462

Query: 745  -VNGTFKCSCPYGMESILDTGLCAPNSQIVDVQFDIPNN 858
             + G F+C C  G E     G C   ++ +D    I  N
Sbjct: 1463 NLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGN 1501

 Score =  120 bits (301), Expect = 5e-27
 Identities = 62/168 (36%), Positives = 89/168 (52%)
 Frame = +1

Query: 307 FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
           +LC+NGRCI +  SY C+CN GFQ    G+ C D+DEC  NP  C  G CIN+ GSY C 
Sbjct: 458 YLCQNGRCIPTPGSYRCECNKGFQLDLRGE-CIDVDECEKNP--CAGGECINNQGSYTCQ 514

Query: 487 CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
           C  G+   +     +C D +EC ++  +C NG CIN  GSF C CN+G+  + + ++C  
Sbjct: 515 CRAGY--QSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCED 572

Query: 667 IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
           + + S  +            +  C   +G+FKC C  G +   D   C
Sbjct: 573 MDECSIRNMC---------LNGMCINEDGSFKCICKPGFQLASDGRYC 611

 Score =  118 bits (295), Expect = 2e-26
 Identities = 76/241 (31%), Positives = 99/241 (41%), Gaps = 50/241 (20%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACK------------KR--------------- 228
            C  GRC+N    YRCEC P   +   G+ C             KR               
Sbjct: 623  CMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSE 682

Query: 229  -----TEY---KPNQMNDAASSFNLKSQCDKFGSF---------------LCKNGRCIES 339
                 TEY   +P Q   A +S   ++ C                     +C NG C   
Sbjct: 683  CCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENL 742

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMP 519
              +Y+C CN G++  S GK C DI+EC  N  +CD G C N+PGS+ C+C  GF     P
Sbjct: 743  RGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIY--KP 800

Query: 520  GGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVD 699
                C D +EC  + S C NGVC N  GSF C+C+S       K  CI     + +  V 
Sbjct: 801  DLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVI 858

Query: 700  D 702
            D
Sbjct: 859  D 859

 Score =  114 bits (286), Expect = 3e-25
 Identities = 76/294 (25%), Positives = 112/294 (38%), Gaps = 58/294 (19%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKK-------RTEYKPNQMNDAASSFNL-KS 285
            C  G C N    Y C C PD++    G  C         R  Y  NQ  D    FN+ K 
Sbjct: 1658 CGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKK 1717

Query: 286  QC----------------------DKFGSF----------------------------LC 315
             C                      D+F +                             +C
Sbjct: 1718 MCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVC 1777

Query: 316  KNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYD 495
            +NG CI    S+ C+C +GF  +    +C DIDEC   P       CIN+ GSY+C C  
Sbjct: 1778 ENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKP 1837

Query: 496  GFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQD 675
            G+         +C DRNEC E  ++C +G CI+  GSF C C++G+  + ++  C+ I +
Sbjct: 1838 GY---RFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINE 1894

Query: 676  SSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
                +  +            C    G+F C C +G        + + N+  +DV
Sbjct: 1895 CERDACGNGT----------CRNTIGSFNCRCNHGF-------ILSHNNDCIDV 1931

 Score =  114 bits (286), Expect = 3e-25
 Identities = 72/261 (27%), Positives = 104/261 (39%), Gaps = 34/261 (13%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ G C+N +  Y C C               +T Y P+    +    N  +Q  K  +F
Sbjct: 2413 CRNGECVNDRGSYHCIC---------------KTGYTPDITGTSCVDLNECNQAPKPCNF 2457

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +CKN     +  SY+C C  G+    DG+ C D+DEC T    C +  C+N+ G + C C
Sbjct: 2458 ICKN-----TEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNC-QFLCVNTIGGFTCKC 2511

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLC-KNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
              GFT H+      C D NEC+ D +LC   G+C N  GSF C+C  G+        C  
Sbjct: 2512 PPGFTQHHT----SCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCED 2567

Query: 667  IQDSSDY-----------------------------SAVDDN----SKYCSKCSHYCAFV 747
            + +                                   VD+N    +  C   S  C   
Sbjct: 2568 VDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGAS--CHNT 2625

Query: 748  NGTFKCSCPYGMESILDTGLC 810
             G++KC CP G +    +G C
Sbjct: 2626 LGSYKCMCPAGFQYEQFSGGC 2646

 Score =  113 bits (282), Expect = 8e-25
 Identities = 66/215 (30%), Positives = 97/215 (45%), Gaps = 3/215 (1%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNG 324
            C N    YRC C   +  D  G  C          +++ + + NL           C NG
Sbjct: 1380 CKNTMGSYRCLCKEGYTGD--GFTC--------TDLDECSENLNL-----------CGNG 1418

Query: 325  RCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFT 504
            +C+ +   Y C+C++GF  S+DGK C DIDEC+  P IC  GTC N PG ++C C  G+ 
Sbjct: 1419 QCLNAPGGYRCECDMGFVPSADGKACEDIDECSL-PNICVFGTCHNLPGLFRCECEIGYE 1477

Query: 505  IHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSD 684
            +     G  C D NEC  D + C +G C+N  GS+ C C   +  +  +  C+  +  + 
Sbjct: 1478 LDR--SGGNCTDVNECL-DPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNC 1534

Query: 685  YSAV---DDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            Y  +    DN    + CS+          C C  G
Sbjct: 1535 YLDIRPRGDNGD--TACSNEIGVGVSKASCCCSLG 1567

 Score =  111 bits (277), Expect = 3e-24
 Identities = 72/248 (29%), Positives = 98/248 (39%), Gaps = 31/248 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    ++C C P F L   G+ CK   E                  C+  G  
Sbjct: 582  CLNGMCINEDGSFKCICKPGFQLASDGRYCKDINE------------------CETPG-- 621

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCI---------- 459
            +C NGRC+ +  SY C+C  G     DG++C D    +T      RG CI          
Sbjct: 622  ICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKS 681

Query: 460  --------------------NSPGSYQCSCYDGFTIHNMPGGPKC-YDRNECSEDKSLCK 576
                                 +   YQ  C  G      PG      D NEC+ D  +C 
Sbjct: 682  ECCCASTEYAFGEPCQPCPAQNSAEYQALCSSG------PGMTSAGSDINECALDPDICP 735

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGT 756
            NG+C N+ G++KC CNSGY   S  ++C+ I +    S + DN +        C    G+
Sbjct: 736  NGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQ--------CRNTPGS 787

Query: 757  FKCSCPYG 780
            F C+CP G
Sbjct: 788  FVCTCPKG 795

 Score =  108 bits (270), Expect = 2e-23
 Identities = 77/305 (25%), Positives = 104/305 (34%), Gaps = 88/305 (28%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFN--LKS 285
            C+ GRC+N +  Y CEC   F        C         TE   N     +S+ N   KS
Sbjct: 2302 CENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKS 2361

Query: 286  QCDKFGSF------------------------------------------LCKNGRCIES 339
            +C   G                                            +C+NG C+  
Sbjct: 2362 ECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVND 2421

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIH--- 510
              SY C C  G+     G  C D++EC   P  C+   C N+ GSYQCSC  G+ +    
Sbjct: 2422 RGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCN-FICKNTEGSYQCSCPKGYILQEDG 2480

Query: 511  ---------------------NMPGG-------------PKCYDRNECSEDKSLC-KNGV 585
                                 N  GG               C D NEC+ D +LC   G+
Sbjct: 2481 RSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGI 2540

Query: 586  CINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKC 765
            C N  GSF C+C  G+        C  +          D  +   +C H C  + G ++C
Sbjct: 2541 CQNTPGSFTCECQRGFSLDQTGSSCEDV----------DECEGNHRCQHGCQNIIGGYRC 2590

Query: 766  SCPYG 780
            SCP G
Sbjct: 2591 SCPQG 2595

 Score =  103 bits (258), Expect = 5e-22
 Identities = 65/233 (27%), Positives = 91/233 (39%), Gaps = 21/233 (9%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMN------DAASSFNLK-------- 282
            C N +  Y+C C   ++L + G++CK   E    Q N      +    F  K        
Sbjct: 2459 CKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQH 2518

Query: 283  -------SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTIC 441
                   ++C    +     G C  +  S+ C+C  GF     G  C D+DEC  N   C
Sbjct: 2519 HTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNHR-C 2577

Query: 442  DRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
              G C N  G Y+CSC  G+  H      +C D NEC     +C    C N  GS+KC C
Sbjct: 2578 QHG-CQNIIGGYRCSCPQGYLQHYQ--WNQCVDENECL-SAHICGGASCHNTLGSYKCMC 2633

Query: 622  NSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             +G+        C  I +     A          CS+ C+   G + C CP G
Sbjct: 2634 PAGFQYEQFSGGCQDINECGSAQA---------PCSYGCSNTEGGYLCGCPPG 2677

 Score =  102 bits (253), Expect = 2e-21
 Identities = 56/173 (32%), Positives = 88/173 (50%), Gaps = 1/173 (0%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT-NPTICDRGTCINSPGSYQCS 486
            +CK+G+CI +  SY C+C  G+  +  G  C D DEC+  NP  C  GTC N  G ++C+
Sbjct: 2136 VCKHGQCINTDGSYRCECPFGYTLA--GNECVDTDECSVGNP--CGNGTCKNVIGGFECT 2191

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C +GF    M     C D NEC+++  LC    C+N +GS++C+C  GYV   +++ C  
Sbjct: 2192 CEEGFEPGPMM---TCEDINECAQNPLLCAFR-CVNTYGSYECKCPVGYVLREDRRMC-- 2245

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQ 825
                 D    ++    C++    C  + GT+ C C  G +   D   C   ++
Sbjct: 2246 ----KDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENE 2294

 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 70/282 (24%), Positives = 99/282 (35%), Gaps = 69/282 (24%)
 Frame = +1

Query: 142  RCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKN 321
            RC+N    Y C+C   +VL +  + CK   E +             K  C +      K 
Sbjct: 2220 RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEG-----------KHDCTE------KQ 2262

Query: 322  GRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGF 501
              C     +Y C C  G+Q   DG+ C D +EC T P IC+ G C+N+ GSY C C DGF
Sbjct: 2263 MECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGF 2322

Query: 502  TIHNMPGGPKCYD--------------------------RNECSED-------------- 561
            T    P   +C D                          ++EC  D              
Sbjct: 2323 TA--SPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPF 2380

Query: 562  ------KSLCKNG------------------VC-----INIHGSFKCQCNSGYVASSNKQ 654
                  K LC +G                  VC     +N  GS+ C C +GY       
Sbjct: 2381 QGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGT 2440

Query: 655  DCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             C+ + + +              C+  C    G+++CSCP G
Sbjct: 2441 SCVDLNECNQAP---------KPCNFICKNTEGSYQCSCPKG 2473

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 67/263 (25%), Positives = 104/263 (39%), Gaps = 22/263 (8%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFNLKS 285
            E C  G C N +  ++C C   F L   G+ C+         +++  + +   S  + K 
Sbjct: 2022 EICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQ 2081

Query: 286  QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDG--KICS--------------DIDE 417
            +C       C    C   G  +   C L   E  +   +IC               D+DE
Sbjct: 2082 EC-------C----CALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130

Query: 418  CTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINI 597
            C   P +C  G CIN+ GSY+C C  G+T+     G +C D +ECS     C NG C N+
Sbjct: 2131 CK-EPDVCKHGQCINTDGSYRCECPFGYTL----AGNECVDTDECSVGNP-CGNGTCKNV 2184

Query: 598  HGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPY 777
             G F+C C  G+        C  I + +    +         C+  C    G+++C CP 
Sbjct: 2185 IGGFECTCEEGFEPGP-MMTCEDINECAQNPLL---------CAFRCVNTYGSYECKCPV 2234

Query: 778  GMESILDTGLCAPNSQIVDVQFD 846
            G     D  +C    +  + + D
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHD 2257

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 69/276 (25%), Positives = 102/276 (36%), Gaps = 59/276 (21%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N++  Y+C C   + +D  G+ C    E   N                   S 
Sbjct: 734  CPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLN-------------------SL 774

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNP------------------- 432
            LC NG+C  +  S+ C C  GF    D K C DIDEC ++P                   
Sbjct: 775  LCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSS 834

Query: 433  --------TICD---RGTCINSPGSYQCSC-YDGFTI----------------------- 507
                    TIC    +GTC  +    +C    +G T+                       
Sbjct: 835  ESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDP 894

Query: 508  -----HNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQ 672
                 ++   G +C D +EC     +CKNG+C+N  GSFKCQC SG    +  + C+ I+
Sbjct: 895  ICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIR 954

Query: 673  DSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
              + +   +D      +C+   A  +    C C  G
Sbjct: 955  LETCFLRYED-----EECTLPIAGRHRMDACCCSVG 985

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 60/225 (26%), Positives = 94/225 (41%), Gaps = 10/225 (4%)
 Frame = +1

Query: 136 GGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLC 315
           GGRC+      RC C   F     G  C++  +Y+        S+   + Q    G    
Sbjct: 157 GGRCVAPN---RCACTYGFT----GPQCER--DYRTGPCFTVISNQMCQGQLS--GIVCT 205

Query: 316 KNGRCIESGSSYECKCNL----------GFQESSDGKICSDIDECTTNPTICDRGTCINS 465
           K   C   G ++   C +          GF  +     C D+DEC   P +C  G CIN+
Sbjct: 206 KQLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINT 265

Query: 466 PGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASS 645
            GS++C C  G  ++ +    KC D +ECS    +C+ G C N   S+ C+C  G+  S 
Sbjct: 266 VGSFECKCPAGHKLNEV--SQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSP 323

Query: 646 NKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
           +   CI ++    Y+A+ +      +CS+         +C C  G
Sbjct: 324 DGTRCIDVRPGYCYTALTN-----GRCSNQLPQSITKMQCCCDAG 363

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 65/256 (25%), Positives = 101/256 (39%), Gaps = 29/256 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYK-PNQMNDAASSFNLKSQCDKFGS 306
            C  G+C+N    YRCEC   FV    G+AC+   E   PN                    
Sbjct: 1415 CGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPN-------------------- 1454

Query: 307  FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
             +C  G C      + C+C +G++    G  C+D++EC  +PT C  G C+N+PGSY C 
Sbjct: 1455 -ICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNEC-LDPTTCISGNCVNTPGSYICD 1512

Query: 487  CYDGFTIHNMPGG------PKCY--DRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
            C   F ++    G        CY   R       + C N + + +     C C+ G    
Sbjct: 1513 CPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGV-SKASCCCSLGKAWG 1571

Query: 643  SNKQDCISIQDSSDYSA-------------------VDDNSKYCSKC-SHYCAFVNGTFK 762
            +  + C ++ ++S+Y                     +D+  +    C    C    G+F+
Sbjct: 1572 TPCEMCPAV-NTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQ 1630

Query: 763  CSCPYGMESILDTGLC 810
            C CP G     DT +C
Sbjct: 1631 CRCPTGYYLNEDTRVC 1646

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 58/219 (26%), Positives = 89/219 (40%), Gaps = 23/219 (10%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRT------EYKPNQMNDAASSFNLKSQC 291
            C  G C+N    Y C+C PDF L+     C          + +P   N   +  N     
Sbjct: 1497 CISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSN----- 1551

Query: 292  DKFGSFLCKNGRCIESGSSYECKCNL-----------------GFQESSDGKICSDIDEC 420
             + G  + K   C   G ++   C +                 GF+ +    I  DIDEC
Sbjct: 1552 -EIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDIDEC 1610

Query: 421  TTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIH 600
               P +C  G CIN+ GS+QC C  G+ ++       C D NEC E   +C  G C N  
Sbjct: 1611 QELPGLCQGGKCINTFGSFQCRCPTGYYLNE--DTRVCDDVNEC-ETPGICGPGTCYNTV 1667

Query: 601  GSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYC 717
            G++ C C   Y+  +   +C+ ++ S  Y     +++ C
Sbjct: 1668 GNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTC 1706

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 52/165 (31%), Positives = 70/165 (42%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C N    + CEC   F LD+ G +C+   E                  C+  G+  C+
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDQTGSSCEDVDE------------------CE--GNHRCQ 2578

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C      Y C C  G+ +      C D +EC  +  IC   +C N+ GSY+C C  G
Sbjct: 2579 HG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENEC-LSAHICGGASCHNTLGSYKCMCPAG 2636

Query: 499  FTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGY 633
            F      GG  C D NEC   ++ C  G C N  G + C C  GY
Sbjct: 2637 FQYEQFSGG--CQDINECGSAQAPCSYG-CSNTEGGYLCGCPPGY 2678

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 43/133 (32%), Positives = 65/133 (48%)
 Frame = +1

Query: 412 DECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCI 591
           D C     +C  G CI +PGSY+C C  GF + ++ G  +C D +EC  +K+ C  G CI
Sbjct: 451 DYCQLVRYLCQNGRCIPTPGSYRCECNKGFQL-DLRG--ECIDVDEC--EKNPCAGGECI 505

Query: 592 NIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
           N  GS+ CQC +GY ++  + +C  I +      + +N +        C   +G+F C C
Sbjct: 506 NNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGR--------CINTDGSFHCVC 557

Query: 772 PYGMESILDTGLC 810
             G     D   C
Sbjct: 558 NAGFHVTRDGKNC 570

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 52/166 (31%), Positives = 76/166 (45%), Gaps = 20/166 (12%)
 Frame = +1

Query: 103 CSFSYYSEQC----KGGRCINMKNQYRCEC-LPDFVLDKQ------GQACKKRTEYKPNQ 249
           C++ +   QC    + G C  + +   C+  L   V  KQ      G+A     E  P Q
Sbjct: 168 CTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKQLCCATVGRAWGHPCEMCPAQ 227

Query: 250 MNDAASSF--NLKS-------QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKIC 402
            +     F  N+++       +C      LC+ G CI +  S+ECKC  G + +   + C
Sbjct: 228 PHPCRRGFIPNIRTGACQDVDECQAIPG-LCQGGNCINTVGSFECKCPAGHKLNEVSQKC 286

Query: 403 SDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYD 540
            DIDEC+T P IC+ G C N+  SY C C  GF  +  P G +C D
Sbjct: 287 EDIDECSTIPGICEGGECTNTVSSYFCKCPPGF--YTSPDGTRCID 330

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 62/271 (22%), Positives = 98/271 (36%), Gaps = 35/271 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+GG+CIN    ++C C   + L++  + C    E                  C+  G  
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE------------------CETPG-- 1656

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDE--CTTN----PTICDRGTCINSPG 471
            +C  G C  +  +Y C C   + + + G  C D+    C  N       CD     N   
Sbjct: 1657 ICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTK 1716

Query: 472  SYQCSCYD-----------------------------GFTIHNMPGGPKCYDRNECSEDK 564
               C  Y+                             GF I    G P   D +EC E  
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLP--VDIDECREIP 1774

Query: 565  SLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAF 744
             +C+NGVCIN+ GSF+C+C  G+  +     C  I +  +      N++        C  
Sbjct: 1775 GVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE--------CIN 1826

Query: 745  VNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
              G+++C C  G      TG C   ++  ++
Sbjct: 1827 TAGSYRCDCKPGYR-FTSTGQCNDRNECQEI 1856

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 49/194 (25%), Positives = 78/194 (40%), Gaps = 24/194 (12%)
 Frame = +1

Query: 301 GSFLCKNGRCIESG---SSYECKCNLGF---QESSDGK-------ICSDIDECTTNPTIC 441
           G  +C++G C+  G   +   C C  GF   Q   D +       I + + +   +  +C
Sbjct: 146 GQPVCESG-CLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVC 204

Query: 442 DRGTCINSPG---SYQCS--------CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVC 588
            +  C  + G    + C         C  GF I N+  G  C D +EC     LC+ G C
Sbjct: 205 TKQLCCATVGRAWGHPCEMCPAQPHPCRRGF-IPNIRTGA-CQDVDECQAIPGLCQGGNC 262

Query: 589 INIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCS 768
           IN  GSF+C+C +G+  +   Q C  I + S    + +  +        C     ++ C 
Sbjct: 263 INTVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGE--------CTNTVSSYFCK 314

Query: 769 CPYGMESILDTGLC 810
           CP G  +  D   C
Sbjct: 315 CPPGFYTSPDGTRC 328
>sp|P98133|FBN1_BOVIN Fibrillin-1 precursor (MP340)
          Length = 2871

 Score =  138 bits (347), Expect = 2e-32
 Identities = 81/239 (33%), Positives = 100/239 (41%), Gaps = 22/239 (9%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQ------------------MN 255
            C+GG C+N +  YRCEC P   L     AC    E + +                    N
Sbjct: 1124 CRGGVCLNTEGSYRCECPPGHQLAPNISACIDINECELSAHLCPHGRCVNLIGKYQCACN 1183

Query: 256  DAASSFNLKSQCDKFGSFLCKNGRC----IESGSSYECKCNLGFQESSDGKICSDIDECT 423
                S   +  C         NG C      S  SYEC C  GF    D + C+DIDEC 
Sbjct: 1184 PGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECE 1243

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
             NP ICD G C N PG Y+C CYDGF          C D NEC  + ++C +G C N  G
Sbjct: 1244 DNPNICDGGQCTNIPGEYRCLCYDGFMASE--DMKTCVDVNECDLNPNICLSGTCENTKG 1301

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            SF C C+ GY     K  C  I +    +   D    C+  +       G+FKCSC  G
Sbjct: 1302 SFICHCDMGYSGKKGKTGCTDINECEIGAHNCDRHAVCTNTA-------GSFKCSCSPG 1353

 Score =  135 bits (341), Expect = 1e-31
 Identities = 76/227 (33%), Positives = 105/227 (46%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ GRCI     YRCEC   F LD +G+                        +C+K    
Sbjct: 460  CQNGRCIPTPGSYRCECNKGFQLDLRGECIDV-------------------DECEKNP-- 498

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C  G CI +  SY C+C  G+Q +     C DIDEC  N  IC+ G CIN+ GS+ C C
Sbjct: 499  -CAGGECINTQGSYTCQCRPGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVC 557

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
              GF  H    G  C D +ECS  +++C NG+CIN  GSFKC C  G+  +S+ + C  I
Sbjct: 558  NAGF--HVTRDGKNCEDMDECS-IRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDI 614

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             +        +           C   +G+++C C  G+   LD  +C
Sbjct: 615  NECETLGICMNGR---------CVNTDGSYRCECFPGLAVGLDGRVC 652

 Score =  134 bits (337), Expect = 3e-31
 Identities = 77/243 (31%), Positives = 123/243 (50%), Gaps = 26/243 (10%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLD------------KQGQACKK-----------RTEYK 240
            C+ G CINM   +RCEC   F  +            + G  C++           R + K
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCK 1836

Query: 241  PNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDEC 420
            P     +    N +++C +  + +C +G+CI++  S+ C C+ GF+ ++D  +C DI+EC
Sbjct: 1837 PGYRFTSTGQCNDRNECQEIPN-ICSHGQCIDTVGSFYCLCHTGFKTNADQTMCLDINEC 1895

Query: 421  TTNPTICDRGTCINSPGSYQCSCYDGFTI-HNMPGGPKCYDRNECSEDK-SLCKNGVCIN 594
              +   C  GTC N+ GS+ C C  GF + HN      C D +EC+    +LC+NG CIN
Sbjct: 1896 ERDA--CGNGTCRNTIGSFNCRCNHGFILSHNND----CIDVDECATGNGNLCRNGQCIN 1949

Query: 595  IHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVNGTFKCSC 771
              GSF+CQCN GY  + + + C+ I +      +D       KC+   C  ++G+++C C
Sbjct: 1950 TVGSFQCQCNEGYEVAPDGRTCVDINEC----LLDPR-----KCAPGTCQNLDGSYRCIC 2000

Query: 772  PYG 780
            P G
Sbjct: 2001 PPG 2003

 Score =  131 bits (330), Expect = 2e-30
 Identities = 72/242 (29%), Positives = 106/242 (43%), Gaps = 7/242 (2%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C N    ++C C   F LD + + C    E +                       
Sbjct: 1039 CTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECR-------------------ISPD 1079

Query: 310  LCKNGRCIESGSSYECKCNLGFQES-SDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
            LC  G+C+ +   +ECKC+ G++      K C DIDEC  +P +C  G C+N+ GSY+C 
Sbjct: 1080 LCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCLNTEGSYRCE 1139

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  G  +   P    C D NEC     LC +G C+N+ G ++C CN GY ++ ++  C+ 
Sbjct: 1140 CPPGHQL--APNISACIDINECELSAHLCPHGRCVNLIGKYQCACNPGYHSTPDRLFCVD 1197

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG------MESILDTGLCAPNSQI 828
            I         D+ S     C  +C    G+++CSC  G        S  D   C  N  I
Sbjct: 1198 I---------DECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNI 1248

Query: 829  VD 834
             D
Sbjct: 1249 CD 1250

 Score =  129 bits (323), Expect = 1e-29
 Identities = 69/216 (31%), Positives = 101/216 (46%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFG 303
            + C  G C N    + C C   F+L                  ND         +C    
Sbjct: 1898 DACGNGTCRNTIGSFNCRCNHGFILSHN---------------NDCIDV----DECATGN 1938

Query: 304  SFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQC 483
              LC+NG+CI +  S++C+CN G++ + DG+ C DI+EC  +P  C  GTC N  GSY+C
Sbjct: 1939 GNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLDPRKCAPGTCQNLDGSYRC 1998

Query: 484  SCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCI 663
             C  G+++ N     KC D +EC E+  +C  G C N  GSFKC C  G+  SS  + C 
Sbjct: 1999 ICPPGYSLQN----DKCEDIDECVEEPEICALGTCSNTEGSFKCLCPDGFSLSSTGRRCQ 2054

Query: 664  SIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
             ++ S  Y+  +       KCS   +  +   +C C
Sbjct: 2055 DLRMSYCYAKFEG-----GKCSSPKSRNHSKQECCC 2085

 Score =  127 bits (320), Expect = 3e-29
 Identities = 66/214 (30%), Positives = 108/214 (50%), Gaps = 1/214 (0%)
 Frame = +1

Query: 172  CECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSY 351
            CE  P     +  + C +   +   ++ +    F   ++C    + LC +G+C  +  S+
Sbjct: 993  CEECPVRNTPEYEELCPRGPGFATKEITNGKRFFKDINECKMIPN-LCTHGKCRNTIGSF 1051

Query: 352  ECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPK 531
            +C+C+ GF   S+ + C+DIDEC  +P +C RG C+N+PG ++C C +G+    M     
Sbjct: 1052 KCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMM-MKN 1110

Query: 532  CYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSK 711
            C D +EC  D  LC+ GVC+N  GS++C+C  G+  + N   CI I +  + SA      
Sbjct: 1111 CMDIDECQRDPLLCRGGVCLNTEGSYRCECPPGHQLAPNISACIDINE-CELSA------ 1163

Query: 712  YCSKCSH-YCAFVNGTFKCSCPYGMESILDTGLC 810
                C H  C  + G ++C+C  G  S  D   C
Sbjct: 1164 --HLCPHGRCVNLIGKYQCACNPGYHSTPDRLFC 1195

 Score =  122 bits (307), Expect = 1e-27
 Identities = 65/179 (36%), Positives = 93/179 (51%)
 Frame = +1

Query: 274 NLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGT 453
           N+   C  F  +LC+NGRCI +  SY C+CN GFQ    G+ C D+DEC  NP  C  G 
Sbjct: 448 NVTDYCQLF-RYLCQNGRCIPTPGSYRCECNKGFQLDLRGE-CIDVDECEKNP--CAGGE 503

Query: 454 CINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGY 633
           CIN+ GSY C C  G+   +     +C D +EC ++  +C NG CIN  GSF C CN+G+
Sbjct: 504 CINTQGSYTCQCRPGY--QSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF 561

Query: 634 VASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             + + ++C  + + S  +            +  C   +G+FKC C  G +   D   C
Sbjct: 562 HVTRDGKNCEDMDECSIRNMC---------LNGMCINEDGSFKCICKPGFQLASDGRYC 611

 Score =  120 bits (301), Expect = 5e-27
 Identities = 78/279 (27%), Positives = 121/279 (43%), Gaps = 36/279 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF-GS 306
            C GG+C N+  +YRC C   F+  +  + C    E       D   +  L   C+   GS
Sbjct: 1249 CDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNEC------DLNPNICLSGTCENTKGS 1302

Query: 307  FLC--------KNGR---------------------CIESGSSYECKCNLGFQESSDGKI 399
            F+C        K G+                     C  +  S++C C+ G+    DG  
Sbjct: 1303 FICHCDMGYSGKKGKTGCTDINECEIGAHNCDRHAVCTNTAGSFKCSCSPGW--IGDGIK 1360

Query: 400  CSDIDECTTNPTICDR-GTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCK 576
            C+D+DEC+    +C +   C N+ GSY+C C +G+T      G  C D +ECSE+ +LC 
Sbjct: 1361 CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT----GDGFTCTDLDECSENLNLCG 1416

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAF---- 744
            NG C+N  G ++C+C+ G+V S++ + C  I + S                + C F    
Sbjct: 1417 NGQCLNAPGGYRCECDMGFVPSADGKACEDIDECS--------------LPNICVFGTCH 1462

Query: 745  -VNGTFKCSCPYGMESILDTGLCAPNSQIVDVQFDIPNN 858
             + G F+C C  G E     G C   ++ +D    I  N
Sbjct: 1463 NLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGN 1501

 Score =  116 bits (291), Expect = 7e-26
 Identities = 75/241 (31%), Positives = 99/241 (41%), Gaps = 50/241 (20%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACK------------KR--------------- 228
            C  GRC+N    YRCEC P   +   G+ C             KR               
Sbjct: 623  CMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCVKPLFGAVTKSE 682

Query: 229  -----TEY---KPNQMNDAASSFNLKSQCDKFGSF---------------LCKNGRCIES 339
                 TEY   +P Q   + +S   ++ C                     +C NG C   
Sbjct: 683  CCCASTEYAFGEPCQPCPSQNSAEYQALCSSGPGITSAGSDINECALDPDICPNGICENL 742

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMP 519
              +Y+C CN G++  S GK C DI+EC  N  +CD G C N+PGS+ C+C  GF     P
Sbjct: 743  RGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIY--KP 800

Query: 520  GGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVD 699
                C D +EC  + S C NGVC N  GSF C+C+S       K  CI     + +  V 
Sbjct: 801  ELKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVI 858

Query: 700  D 702
            D
Sbjct: 859  D 859

 Score =  116 bits (290), Expect = 9e-26
 Identities = 74/261 (28%), Positives = 105/261 (40%), Gaps = 34/261 (13%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ G C+N +  Y C C               +T Y P+    A    N  +Q  K  +F
Sbjct: 2413 CRNGECVNDRGSYHCIC---------------KTGYTPDITGTACVDLNECNQAPKPCNF 2457

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +CKN     +  SY+C C  G+    DG+ C D+DEC T    C +  C+N+ GS+ C C
Sbjct: 2458 ICKN-----TEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNC-QFLCVNTIGSFTCKC 2511

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLC-KNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
              GFT H+      C D NEC+ D +LC   G+C N  GSF C+C  G+        C  
Sbjct: 2512 PPGFTQHHTA----CIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDPTGASCED 2567

Query: 667  IQDSSDY-----------------------------SAVDDN----SKYCSKCSHYCAFV 747
            + +                                   VD+N    +  C   S  C   
Sbjct: 2568 VDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGAS--CHNT 2625

Query: 748  NGTFKCSCPYGMESILDTGLC 810
             G++KC CP G +    +G C
Sbjct: 2626 LGSYKCMCPAGFQYEQFSGGC 2646

 Score =  115 bits (289), Expect = 1e-25
 Identities = 69/227 (30%), Positives = 100/227 (44%), Gaps = 3/227 (1%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNG 324
            C N    YRC C   +  D  G  C          +++ + + NL           C NG
Sbjct: 1380 CKNTMGSYRCLCKEGYTGD--GFTC--------TDLDECSENLNL-----------CGNG 1418

Query: 325  RCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFT 504
            +C+ +   Y C+C++GF  S+DGK C DIDEC+  P IC  GTC N PG ++C C  G+ 
Sbjct: 1419 QCLNAPGGYRCECDMGFVPSADGKACEDIDECSL-PNICVFGTCHNLPGLFRCECEIGYE 1477

Query: 505  IHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSD 684
            +     G  C D NEC  D + C +G C+N  GS+ C C   +  +  +  C+  +  + 
Sbjct: 1478 LDR--SGGNCTDVNECL-DPTTCISGNCVNTPGSYTCDCPPDFELNPTRVGCVDTRSGNC 1534

Query: 685  YSAV---DDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAP 816
            Y  +    DN    + CS+          C C  G        LC P
Sbjct: 1535 YLDIRPRGDNGD--TACSNEIGVGVSKASCCCSLGKAWGTPCELCPP 1579

 Score =  115 bits (287), Expect = 2e-25
 Identities = 76/294 (25%), Positives = 113/294 (38%), Gaps = 58/294 (19%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKK-------RTEYKPNQMNDAASSFNL-KS 285
            C  G C N    Y C C PD++    G  C         R  Y  NQ  D    FN+ K 
Sbjct: 1658 CGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKK 1717

Query: 286  QC----------------------DKFGSF----------------------------LC 315
             C                      D+F +                             +C
Sbjct: 1718 MCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVC 1777

Query: 316  KNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYD 495
            +NG CI    S+ C+C +GF  +    +C DIDEC   P       CIN+ GSY+C C  
Sbjct: 1778 ENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKP 1837

Query: 496  GFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQD 675
            G+         +C DRNEC E  ++C +G CI+  GSF C C++G+  ++++  C+ I +
Sbjct: 1838 GY---RFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNADQTMCLDINE 1894

Query: 676  SSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
                +  +            C    G+F C C +G        + + N+  +DV
Sbjct: 1895 CERDACGNGT----------CRNTIGSFNCRCNHGF-------ILSHNNDCIDV 1931

 Score =  112 bits (280), Expect = 1e-24
 Identities = 70/247 (28%), Positives = 98/247 (39%), Gaps = 30/247 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    ++C C P F L   G+ CK   E                  C+  G  
Sbjct: 582  CLNGMCINEDGSFKCICKPGFQLASDGRYCKDINE------------------CETLG-- 621

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCI---------- 459
            +C NGRC+ +  SY C+C  G     DG++C D    +T      RG C+          
Sbjct: 622  ICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCVKPLFGAVTKS 681

Query: 460  --------------------NSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKN 579
                                 +   YQ  C  G  I +        D NEC+ D  +C N
Sbjct: 682  ECCCASTEYAFGEPCQPCPSQNSAEYQALCSSGPGITSAGS-----DINECALDPDICPN 736

Query: 580  GVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTF 759
            G+C N+ G++KC CNSGY   S  ++C+ I +    S + DN +        C    G+F
Sbjct: 737  GICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQ--------CRNTPGSF 788

Query: 760  KCSCPYG 780
             C+CP G
Sbjct: 789  VCTCPKG 795

 Score =  112 bits (279), Expect = 2e-24
 Identities = 66/234 (28%), Positives = 90/234 (38%), Gaps = 42/234 (17%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            CK G+CIN    YRCEC   ++L  QG  C    E                         
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYIL--QGNECVDTDECSVGNP------------------- 2175

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C NG C      +EC C  GF E      C DI+EC  NP +C    C+N+ GSY+C C
Sbjct: 2176 -CGNGTCKNVIGGFECTCEEGF-EPGPMMTCEDINECAQNPLLC-AFRCVNTYGSYECKC 2232

Query: 490  YDGFTI------------------------------------------HNMPGGPKCYDR 543
              G+ +                                             P G  C D 
Sbjct: 2233 PAGYVLREDRRMCKDEDECEEGKHDCAEKQMECKNLIGTYLCICGPGYQRRPDGEGCVDE 2292

Query: 544  NECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDN 705
            NEC     +C+NG C+N  GS+ C+CN G+ AS N+ +C+  ++   ++ V  N
Sbjct: 2293 NECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQN 2346

 Score =  107 bits (268), Expect = 3e-23
 Identities = 78/305 (25%), Positives = 106/305 (34%), Gaps = 88/305 (28%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFN--LKS 285
            C+ GRC+N +  Y CEC   F        C         TE   N     +S+ N   KS
Sbjct: 2302 CENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKS 2361

Query: 286  QCDKFGSF------------------------------------------LCKNGRCIES 339
            +C   G                                            +C+NG C+  
Sbjct: 2362 ECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVND 2421

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTI---- 507
              SY C C  G+     G  C D++EC   P  C+   C N+ GSYQCSC  G+ +    
Sbjct: 2422 RGSYHCICKTGYTPDITGTACVDLNECNQAPKPCN-FICKNTEGSYQCSCPKGYILQEDG 2480

Query: 508  -------------HNM----------------PGGPK----CYDRNECSEDKSLC-KNGV 585
                         HN                 PG  +    C D NEC+ D +LC   G+
Sbjct: 2481 RSCKDLDECATKQHNCQFLCVNTIGSFTCKCPPGFTQHHTACIDNNECTSDINLCGSKGI 2540

Query: 586  CINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKC 765
            C N  GSF C+C  G+        C  +          D  +   +C H C  + G ++C
Sbjct: 2541 CQNTPGSFTCECQRGFSLDPTGASCEDV----------DECEGNHRCQHGCQNIIGGYRC 2590

Query: 766  SCPYG 780
            SCP G
Sbjct: 2591 SCPQG 2595

 Score =  105 bits (261), Expect = 2e-22
 Identities = 66/233 (28%), Positives = 93/233 (39%), Gaps = 21/233 (9%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMN------DAASSFNLK-------- 282
            C N +  Y+C C   ++L + G++CK   E    Q N      +   SF  K        
Sbjct: 2459 CKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGSFTCKCPPGFTQH 2518

Query: 283  -------SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTIC 441
                   ++C    +     G C  +  S+ C+C  GF     G  C D+DEC  N   C
Sbjct: 2519 HTACIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDPTGASCEDVDECEGNHR-C 2577

Query: 442  DRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
              G C N  G Y+CSC  G+  H      +C D NEC     +C    C N  GS+KC C
Sbjct: 2578 QHG-CQNIIGGYRCSCPQGYLQHYQ--WNQCVDENECL-SAHICGGASCHNTLGSYKCMC 2633

Query: 622  NSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             +G+        C  I +     A          CS+ C+   G + C+CP G
Sbjct: 2634 PAGFQYEQFSGGCQDINECGSAQA---------PCSYGCSNTEGGYLCACPPG 2677

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 70/282 (24%), Positives = 100/282 (35%), Gaps = 69/282 (24%)
 Frame = +1

Query: 142  RCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKN 321
            RC+N    Y C+C   +VL +  + CK   E +  + + A                 CKN
Sbjct: 2220 RCVNTYGSYECKCPAGYVLREDRRMCKDEDECEEGKHDCAEKQME------------CKN 2267

Query: 322  GRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGF 501
                    +Y C C  G+Q   DG+ C D +EC T P IC+ G C+N+ GSY C C DGF
Sbjct: 2268 -----LIGTYLCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGF 2322

Query: 502  TIHNMPGGPKCYD--------------------------RNECSED-------------- 561
            T    P   +C D                          ++EC  D              
Sbjct: 2323 TA--SPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPF 2380

Query: 562  ------KSLCKNG------------------VC-----INIHGSFKCQCNSGYVASSNKQ 654
                  K LC +G                  VC     +N  GS+ C C +GY       
Sbjct: 2381 QGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGT 2440

Query: 655  DCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             C+ + + +              C+  C    G+++CSCP G
Sbjct: 2441 ACVDLNECNQAP---------KPCNFICKNTEGSYQCSCPKG 2473

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 66/263 (25%), Positives = 103/263 (39%), Gaps = 22/263 (8%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFNLKS 285
            E C  G C N +  ++C C   F L   G+ C+         +++  + +   S  + K 
Sbjct: 2022 EICALGTCSNTEGSFKCLCPDGFSLSSTGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQ 2081

Query: 286  QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDG--KICS--------------DIDE 417
            +C       C    C   G  +   C L   E  +   +IC               D+DE
Sbjct: 2082 EC-------C----CALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130

Query: 418  CTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINI 597
            C   P +C  G CIN+ GSY+C C  G+ +     G +C D +ECS     C NG C N+
Sbjct: 2131 CK-EPDVCKHGQCINTDGSYRCECPFGYILQ----GNECVDTDECSVGNP-CGNGTCKNV 2184

Query: 598  HGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPY 777
             G F+C C  G+        C  I + +    +         C+  C    G+++C CP 
Sbjct: 2185 IGGFECTCEEGFEPGP-MMTCEDINECAQNPLL---------CAFRCVNTYGSYECKCPA 2234

Query: 778  GMESILDTGLCAPNSQIVDVQFD 846
            G     D  +C    +  + + D
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHD 2257

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 59/219 (26%), Positives = 89/219 (40%), Gaps = 23/219 (10%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRT------EYKPNQMNDAASSFNLKSQC 291
            C  G C+N    Y C+C PDF L+     C          + +P   N   +  N     
Sbjct: 1497 CISGNCVNTPGSYTCDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSN----- 1551

Query: 292  DKFGSFLCKNGRCIESGSSYECKCNL-----------------GFQESSDGKICSDIDEC 420
             + G  + K   C   G ++   C L                 GF+ +    I  DIDEC
Sbjct: 1552 -EIGVGVSKASCCCSLGKAWGTPCELCPPVNTSEYKILCPGGEGFRPNPITVILEDIDEC 1610

Query: 421  TTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIH 600
               P +C  G CIN+ GS+QC C  G+ ++       C D NEC E   +C  G C N  
Sbjct: 1611 QELPGLCQGGKCINTFGSFQCRCPTGYYLNE--DTRVCDDVNEC-ETPGICGPGTCYNTV 1667

Query: 601  GSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYC 717
            G++ C C   Y+  +   +C+ ++ S  Y     +++ C
Sbjct: 1668 GNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTC 1706

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 65/256 (25%), Positives = 100/256 (39%), Gaps = 29/256 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYK-PNQMNDAASSFNLKSQCDKFGS 306
            C  G+C+N    YRCEC   FV    G+AC+   E   PN                    
Sbjct: 1415 CGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPN-------------------- 1454

Query: 307  FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
             +C  G C      + C+C +G++    G  C+D++EC  +PT C  G C+N+PGSY C 
Sbjct: 1455 -ICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNEC-LDPTTCISGNCVNTPGSYTCD 1512

Query: 487  CYDGFTIHNMPGG------PKCY--DRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
            C   F ++    G        CY   R       + C N + + +     C C+ G    
Sbjct: 1513 CPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGV-SKASCCCSLGKAWG 1571

Query: 643  SNKQDCISIQDSSDYSA-------------------VDDNSKYCSKC-SHYCAFVNGTFK 762
            +  + C  + ++S+Y                     +D+  +    C    C    G+F+
Sbjct: 1572 TPCELCPPV-NTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQ 1630

Query: 763  CSCPYGMESILDTGLC 810
            C CP G     DT +C
Sbjct: 1631 CRCPTGYYLNEDTRVC 1646

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 68/276 (24%), Positives = 102/276 (36%), Gaps = 59/276 (21%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N++  Y+C C   + +D  G+ C    E   N                   S 
Sbjct: 734  CPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLN-------------------SL 774

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNP------------------- 432
            LC NG+C  +  S+ C C  GF    + K C DIDEC ++P                   
Sbjct: 775  LCDNGQCRNTPGSFVCTCPKGFIYKPELKTCEDIDECESSPCINGVCKNSPGSFICECSS 834

Query: 433  --------TICD---RGTCINSPGSYQCSC-YDGFTI----------------------- 507
                    TIC    +GTC  +    +C    +G T+                       
Sbjct: 835  ESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTPCQVDP 894

Query: 508  -----HNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQ 672
                 ++   G +C D +EC     +CKNG+C+N  GSFKCQC SG    +  + C+ I+
Sbjct: 895  ICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNSKGSFKCQCPSGMTLDATGRICLDIR 954

Query: 673  DSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
              + +   +D      +C+   A  +    C C  G
Sbjct: 955  LETCFLRYED-----EECTLPVAGRHRMDACCCSVG 985

 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 52/165 (31%), Positives = 69/165 (41%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C N    + CEC   F LD  G +C+   E                  C+  G+  C+
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDPTGASCEDVDE------------------CE--GNHRCQ 2578

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C      Y C C  G+ +      C D +EC  +  IC   +C N+ GSY+C C  G
Sbjct: 2579 HG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENEC-LSAHICGGASCHNTLGSYKCMCPAG 2636

Query: 499  FTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGY 633
            F      GG  C D NEC   ++ C  G C N  G + C C  GY
Sbjct: 2637 FQYEQFSGG--CQDINECGSAQAPCSYG-CSNTEGGYLCACPPGY 2678

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 64/230 (27%), Positives = 94/230 (40%), Gaps = 24/230 (10%)
 Frame = +1

Query: 103 CSFSYYSEQC----KGGRCINMKNQYRCE-------CLPDFVLDKQGQACKKRTEYKPNQ 249
           C++ +   QC    + G C  + +   C+       C         G+A     E  P Q
Sbjct: 168 CTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227

Query: 250 MNDAASSF--NLKS-------QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKIC 402
            +     F  N+++       +C      LC+ G CI +  S+ECKC  G + +   + C
Sbjct: 228 PHPCRRGFIPNIRTGACQDVDECQAIPG-LCQGGNCINTVGSFECKCPAGHKFNEVSQKC 286

Query: 403 SDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNG 582
            DIDEC+T P ICD G C N+  SY C C  GF  +  P G +C D        +L  NG
Sbjct: 287 EDIDECSTIPGICDGGECTNTVSSYFCKCPPGF--YTSPDGTRCIDVRPGYCYTALA-NG 343

Query: 583 VCIN----IHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCS 720
            C N         +C C++G   S          +     A +D +K CS
Sbjct: 344 RCSNQLPQSITKMQCCCDAGRCWSPG---VTVAPEMCPIRATEDFNKLCS 390

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 62/271 (22%), Positives = 98/271 (36%), Gaps = 35/271 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+GG+CIN    ++C C   + L++  + C    E                  C+  G  
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE------------------CETPG-- 1656

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDE--CTTN----PTICDRGTCINSPG 471
            +C  G C  +  +Y C C   + + + G  C D+    C  N       CD     N   
Sbjct: 1657 ICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTK 1716

Query: 472  SYQCSCYD-----------------------------GFTIHNMPGGPKCYDRNECSEDK 564
               C  Y+                             GF I    G P   D +EC E  
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLP--VDIDECREIP 1774

Query: 565  SLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAF 744
             +C+NGVCIN+ GSF+C+C  G+  +     C  I +  +      N++        C  
Sbjct: 1775 GVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE--------CIN 1826

Query: 745  VNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
              G+++C C  G      TG C   ++  ++
Sbjct: 1827 TAGSYRCDCKPGYR-FTSTGQCNDRNECQEI 1856

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 42/139 (30%), Positives = 55/139 (39%), Gaps = 10/139 (7%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQ-MNDAASSFN-----LK 282
            S  C  G C N    + CEC  +  LD     C +  +    Q + D     N     LK
Sbjct: 813  SSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGATLK 872

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECK----CNLGFQESSDGKICSDIDECTTNPTICDRG 450
            SQC       C +           C+    C  G+     G  C DIDEC   P +C  G
Sbjct: 873  SQC-------CSSLGAAWGSPCTPCQVDPICGKGYSRIK-GTQCEDIDECEVFPGVCKNG 924

Query: 451  TCINSPGSYQCSCYDGFTI 507
             C+NS GS++C C  G T+
Sbjct: 925  LCVNSKGSFKCQCPSGMTL 943

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 50/194 (25%), Positives = 78/194 (40%), Gaps = 24/194 (12%)
 Frame = +1

Query: 301 GSFLCKNGRCIESG---SSYECKCNLGF---QESSDGK-------ICSDIDECTTNPTIC 441
           G  +C++G C+  G   +   C C  GF   Q   D +       I + + +   +  +C
Sbjct: 146 GQPVCESG-CLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVC 204

Query: 442 DRGTCINSPG---SYQCS--------CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVC 588
            +  C  + G    + C         C  GF I N+  G  C D +EC     LC+ G C
Sbjct: 205 TKTLCCATVGRAWGHPCEMCPAQPHPCRRGF-IPNIRTGA-CQDVDECQAIPGLCQGGNC 262

Query: 589 INIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCS 768
           IN  GSF+C+C +G+  +   Q C  I + S    + D  +        C     ++ C 
Sbjct: 263 INTVGSFECKCPAGHKFNEVSQKCEDIDECSTIPGICDGGE--------CTNTVSSYFCK 314

Query: 769 CPYGMESILDTGLC 810
           CP G  +  D   C
Sbjct: 315 CPPGFYTSPDGTRC 328
>sp|Q9TV36|FBN1_PIG Fibrillin-1 precursor
          Length = 2871

 Score =  137 bits (344), Expect = 5e-32
 Identities = 78/227 (34%), Positives = 108/227 (47%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  GRCI     YRCEC   F LD +G+                        +C+K    
Sbjct: 460  CHNGRCIPTPGSYRCECNKGFQLDLRGECIDV-------------------DECEKNP-- 498

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C  G CI +  SY C+C  G+Q +     C DIDEC  N  IC+ G CIN+ GS+ C C
Sbjct: 499  -CAGGECINNQGSYTCQCRPGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVC 557

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
              GF  H    G  C D +ECS  +++C NG+CIN  GSFKC C  G+  +S+ + C  I
Sbjct: 558  NAGF--HVTRDGKNCEDMDECS-IRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDI 614

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             +  + S +  N +        C   +G+++C C  G+   LD  +C
Sbjct: 615  NE-CETSGICMNGR--------CVNTDGSYRCECFPGLAVGLDGRVC 652

 Score =  133 bits (335), Expect = 6e-31
 Identities = 78/239 (32%), Positives = 97/239 (40%), Gaps = 22/239 (9%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYK------------------PNQMN 255
            C+GG C+N +  YRCEC     +     AC    E +                      N
Sbjct: 1124 CRGGVCLNTEGSYRCECPSGHQMSPNISACIDINECELSAHLCPHGRCVNLIGKYQRARN 1183

Query: 256  DAASSFNLKSQCDKFGSFLCKNGRC----IESGSSYECKCNLGFQESSDGKICSDIDECT 423
                S   +  C         NG C      S  SYEC C  GF    D + C+DIDEC 
Sbjct: 1184 PGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECE 1243

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
             NP ICD G C N PG Y+C CYDGF          C D NEC  + ++C +G C N  G
Sbjct: 1244 DNPNICDGGQCTNIPGEYRCLCYDGFMASE--DMKTCVDVNECDLNPNICLSGTCENTKG 1301

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            SF C C+ GY     K  C  I +    +   D    C+  +       G+F CSC  G
Sbjct: 1302 SFICHCDMGYSGKKGKTGCTDINECEIGAHNCDRHAVCTNTA-------GSFNCSCSPG 1353

 Score =  133 bits (334), Expect = 8e-31
 Identities = 76/243 (31%), Positives = 121/243 (49%), Gaps = 26/243 (10%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLD------------KQGQACKK-----------RTEYK 240
            C+ G CINM   +RCEC   F  +            + G  C++           R + K
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCK 1836

Query: 241  PNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDEC 420
            P     +    N +++C +  + +C +G+CI++  S+ C C+ GF+ ++D  +C DI+EC
Sbjct: 1837 PGYRFTSTGQCNDRNECQEIPN-ICSHGQCIDTVGSFYCLCHTGFKTNADQTMCLDINEC 1895

Query: 421  TTNPTICDRGTCINSPGSYQCSCYDGFTI-HNMPGGPKCYDRNECSEDK-SLCKNGVCIN 594
              +   C  GTC N+ GS+ C C  GF + HN      C D +EC+    +LC+NG CIN
Sbjct: 1896 ERDA--CGNGTCRNTIGSFNCRCNHGFILSHNND----CIDVDECATGNGNLCRNGQCIN 1949

Query: 595  IHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVNGTFKCSC 771
              GSF+CQCN GY  + + + C+ I +               KC+   C  ++G+++C C
Sbjct: 1950 TVGSFQCQCNEGYEVAPDGRTCVDINECLLEPG---------KCAPGTCQNLDGSYRCIC 2000

Query: 772  PYG 780
            P G
Sbjct: 2001 PPG 2003

 Score =  128 bits (321), Expect = 2e-29
 Identities = 69/216 (31%), Positives = 100/216 (46%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFG 303
            + C  G C N    + C C   F+L                  ND         +C    
Sbjct: 1898 DACGNGTCRNTIGSFNCRCNHGFILSHN---------------NDCIDV----DECATGN 1938

Query: 304  SFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQC 483
              LC+NG+CI +  S++C+CN G++ + DG+ C DI+EC   P  C  GTC N  GSY+C
Sbjct: 1939 GNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPGKCAPGTCQNLDGSYRC 1998

Query: 484  SCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCI 663
             C  G+++ N     KC D +EC E+  +C  G C N  GSFKC C  G+  SS  + C 
Sbjct: 1999 ICPPGYSLQN----DKCEDIDECVEEPEICALGTCSNTEGSFKCLCPDGFSLSSTGRRCQ 2054

Query: 664  SIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
             ++ S  Y+  +       KCS   +  +   +C C
Sbjct: 2055 DLRMSYCYAKFEG-----GKCSSPKSRNHSKQECCC 2085

 Score =  127 bits (319), Expect = 4e-29
 Identities = 73/261 (27%), Positives = 115/261 (44%), Gaps = 40/261 (15%)
 Frame = +1

Query: 172  CECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSY 351
            CE  P     +  + C +   +   ++ +    F   ++C    + LC +G+C  +  S+
Sbjct: 993  CEECPPRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPN-LCTHGKCRNTIGSF 1051

Query: 352  ECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPK 531
            +C+C+ GF   S+ + C DIDEC  +P +C RG C+N+PG ++C C +G+    M     
Sbjct: 1052 KCRCDSGFALDSEERNCIDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMM-KN 1110

Query: 532  CYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSA------ 693
            C D +EC  D  LC+ GVC+N  GS++C+C SG+  S N   CI I +  + SA      
Sbjct: 1111 CMDIDECQRDPLLCRGGVCLNTEGSYRCECPSGHQMSPNISACIDINEC-ELSAHLCPHG 1169

Query: 694  ----------------------------VDDNSKYCSKCSHYCAFVNGTFKCSCPYG--- 780
                                        +D+ S     C  +C    G+++CSC  G   
Sbjct: 1170 RCVNLIGKYQRARNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFAL 1229

Query: 781  ---MESILDTGLCAPNSQIVD 834
                 S  D   C  N  I D
Sbjct: 1230 MPDQRSCTDIDECEDNPNICD 1250

 Score =  122 bits (305), Expect = 2e-27
 Identities = 65/179 (36%), Positives = 92/179 (51%)
 Frame = +1

Query: 274 NLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGT 453
           N+   C  F  +LC NGRCI +  SY C+CN GFQ    G+ C D+DEC  NP  C  G 
Sbjct: 448 NVTDYCQLF-RYLCHNGRCIPTPGSYRCECNKGFQLDLRGE-CIDVDECEKNP--CAGGE 503

Query: 454 CINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGY 633
           CIN+ GSY C C  G+   +     +C D +EC ++  +C NG CIN  GSF C CN+G+
Sbjct: 504 CINNQGSYTCQCRPGY--QSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF 561

Query: 634 VASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             + + ++C  + + S  +            +  C   +G+FKC C  G +   D   C
Sbjct: 562 HVTRDGKNCEDMDECSIRNMC---------LNGMCINEDGSFKCICKPGFQLASDGRYC 611

 Score =  117 bits (292), Expect = 6e-26
 Identities = 75/261 (28%), Positives = 106/261 (40%), Gaps = 34/261 (13%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ G CIN +  Y C C               +T Y P+    A    N  +Q  K  +F
Sbjct: 2413 CRNGECINDRGSYHCIC---------------KTGYTPDITGTACVDLNECNQAPKPCNF 2457

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +CKN     +  SY+C C  G+    DG+ C D+DEC T    C +  C+N+ GS+ C C
Sbjct: 2458 ICKN-----TEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNC-QFLCVNTIGSFACKC 2511

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLC-KNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
              GFT H+      C D NEC+ D +LC   G+C N  GSF C+C  G+    +   C  
Sbjct: 2512 PPGFTQHHTA----CIDNNECTSDINLCGAKGICQNTPGSFTCECQRGFSLDQSGASCED 2567

Query: 667  IQDSSDY-----------------------------SAVDDN----SKYCSKCSHYCAFV 747
            + +                                   VD+N    +  C   S  C   
Sbjct: 2568 VDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGAS--CHNT 2625

Query: 748  NGTFKCSCPYGMESILDTGLC 810
             G++KC CP G +    +G C
Sbjct: 2626 LGSYKCMCPAGFQYEQFSGGC 2646

 Score =  116 bits (291), Expect = 7e-26
 Identities = 74/241 (30%), Positives = 99/241 (41%), Gaps = 50/241 (20%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACK------------KR--------------- 228
            C  GRC+N    YRCEC P   +   G+ C             KR               
Sbjct: 623  CMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCVKPLFGAVTKSE 682

Query: 229  -----TEY---KPNQMNDAASSFNLKSQCDKFGSF---------------LCKNGRCIES 339
                 TEY   +P Q   + +S   ++ C                     +C NG C   
Sbjct: 683  CCCASTEYAFGEPCQPCPSQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENL 742

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMP 519
              +Y+C CN G++  S GK C DI+EC  N  +CD G C N+PGS+ C+C  GF     P
Sbjct: 743  RGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIY--KP 800

Query: 520  GGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVD 699
                C D +EC  + S C NGVC N  GSF C+C+S       K  CI     + +  + 
Sbjct: 801  DLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTII 858

Query: 700  D 702
            D
Sbjct: 859  D 859

 Score =  115 bits (287), Expect = 2e-25
 Identities = 76/294 (25%), Positives = 113/294 (38%), Gaps = 58/294 (19%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKK-------RTEYKPNQMNDAASSFNL-KS 285
            C  G C N    Y C C PD++    G  C         R  Y  NQ  D    FN+ K 
Sbjct: 1658 CGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKK 1717

Query: 286  QC----------------------DKFGSF----------------------------LC 315
             C                      D+F +                             +C
Sbjct: 1718 MCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVC 1777

Query: 316  KNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYD 495
            +NG CI    S+ C+C +GF  +    +C DIDEC   P       CIN+ GSY+C C  
Sbjct: 1778 ENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKP 1837

Query: 496  GFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQD 675
            G+         +C DRNEC E  ++C +G CI+  GSF C C++G+  ++++  C+ I +
Sbjct: 1838 GY---RFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNADQTMCLDINE 1894

Query: 676  SSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
                +  +            C    G+F C C +G        + + N+  +DV
Sbjct: 1895 CERDACGNGT----------CRNTIGSFNCRCNHGF-------ILSHNNDCIDV 1931

 Score =  111 bits (278), Expect = 2e-24
 Identities = 71/248 (28%), Positives = 98/248 (39%), Gaps = 31/248 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    ++C C P F L   G+ CK   E                  C+  G  
Sbjct: 582  CLNGMCINEDGSFKCICKPGFQLASDGRYCKDINE------------------CETSG-- 621

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCI---------- 459
            +C NGRC+ +  SY C+C  G     DG++C D    +T      RG C+          
Sbjct: 622  ICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCVKPLFGAVTKS 681

Query: 460  --------------------NSPGSYQCSCYDGFTIHNMPGGPKC-YDRNECSEDKSLCK 576
                                 +   YQ  C  G      PG      D NEC+ D  +C 
Sbjct: 682  ECCCASTEYAFGEPCQPCPSQNSAEYQALCSSG------PGMTSAGSDINECALDPDICP 735

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGT 756
            NG+C N+ G++KC CNSGY   S  ++C+ I +    S + DN +        C    G+
Sbjct: 736  NGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQ--------CRNTPGS 787

Query: 757  FKCSCPYG 780
            F C+CP G
Sbjct: 788  FVCTCPKG 795

 Score =  109 bits (272), Expect = 1e-23
 Identities = 73/274 (26%), Positives = 119/274 (43%), Gaps = 31/274 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF-GS 306
            C GG+C N+  +YRC C   F+  +  + C    E       D   +  L   C+   GS
Sbjct: 1249 CDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNEC------DLNPNICLSGTCENTKGS 1302

Query: 307  FLC--------KNGR---------------------CIESGSSYECKCNLGFQESSDGKI 399
            F+C        K G+                     C  +  S+ C C+ G+    DG  
Sbjct: 1303 FICHCDMGYSGKKGKTGCTDINECEIGAHNCDRHAVCTNTAGSFNCSCSPGW--IGDGIK 1360

Query: 400  CSDIDECTTNPTICDR-GTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCK 576
            C+D+DEC+    +C +   C N+ GSY+C C +G+T      G  C D +ECSE+  LC 
Sbjct: 1361 CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT----GDGFTCADLDECSENVKLCG 1416

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGT 756
            N  C+   G + C+ + G+V S++++ C+     SD  ++ +   + +     C  + G 
Sbjct: 1417 NVQCLYAPGGYHCEYDMGFVPSADRKSCV----DSDECSLPNICVFGT-----CHNLPGL 1467

Query: 757  FKCSCPYGMESILDTGLCAPNSQIVDVQFDIPNN 858
            F+C C  G E     G C   ++ ++    I  N
Sbjct: 1468 FRCECEIGYELDRSGGNCTDVNECLEPPTCISGN 1501

 Score =  108 bits (271), Expect = 2e-23
 Identities = 64/234 (27%), Positives = 89/234 (38%), Gaps = 42/234 (17%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            CK G+CIN    YRCEC   ++L+  G  C    E                         
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILE--GNECVDTDECSVGNP------------------- 2175

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C NG C      +EC C  GF E      C DI+EC  NP +C    C+N+ GSY+C C
Sbjct: 2176 -CGNGTCKNVIGGFECTCEEGF-EPGPMMTCEDINECAQNPLLC-AFRCVNTYGSYECKC 2232

Query: 490  YDGFTI------------------------------------------HNMPGGPKCYDR 543
              G+ +                                             P G  C D 
Sbjct: 2233 PTGYVLREDRRMCKDEDECEEGKHDCAEKQMECKNLIGMYICICGPGYQRRPDGEGCVDE 2292

Query: 544  NECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDN 705
            NEC     +C+NG C+N  GS+ C+CN G+ AS  + +C+  ++   ++ V  N
Sbjct: 2293 NECQTKPGICENGRCLNTRGSYTCECNDGFTASPTQDECLDNREGYCFTEVLQN 2346

 Score =  108 bits (269), Expect = 3e-23
 Identities = 79/305 (25%), Positives = 107/305 (35%), Gaps = 88/305 (28%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFN--LKS 285
            C+ GRC+N +  Y CEC   F        C         TE   N     +S+ N   KS
Sbjct: 2302 CENGRCLNTRGSYTCECNDGFTASPTQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKS 2361

Query: 286  QCDKFGSF------------------------------------------LCKNGRCIES 339
            +C   G                                            +C+NG CI  
Sbjct: 2362 ECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECIND 2421

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTI---- 507
              SY C C  G+     G  C D++EC   P  C+   C N+ GSYQCSC  G+ +    
Sbjct: 2422 RGSYHCICKTGYTPDITGTACVDLNECNQAPKPCN-FICKNTEGSYQCSCPKGYILQEDG 2480

Query: 508  -------------HNM----------------PGGPK----CYDRNECSEDKSLC-KNGV 585
                         HN                 PG  +    C D NEC+ D +LC   G+
Sbjct: 2481 RSCKDLDECATKQHNCQFLCVNTIGSFACKCPPGFTQHHTACIDNNECTSDINLCGAKGI 2540

Query: 586  CINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKC 765
            C N  GSF C+C  G+    +   C  +          D  +   +C H C  + G ++C
Sbjct: 2541 CQNTPGSFTCECQRGFSLDQSGASCEDV----------DECEGNHRCQHGCQNIIGGYRC 2590

Query: 766  SCPYG 780
            SCP G
Sbjct: 2591 SCPQG 2595

 Score =  104 bits (259), Expect = 4e-22
 Identities = 68/239 (28%), Positives = 90/239 (37%), Gaps = 27/239 (11%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK-- 318
            C N +  Y+C C   ++L + G++CK   E    Q N      N        GSF CK  
Sbjct: 2459 CKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNT------IGSFACKCP 2512

Query: 319  -------------------------NGRCIESGSSYECKCNLGFQESSDGKICSDIDECT 423
                                      G C  +  S+ C+C  GF     G  C D+DEC 
Sbjct: 2513 PGFTQHHTACIDNNECTSDINLCGAKGICQNTPGSFTCECQRGFSLDQSGASCEDVDECE 2572

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
             N   C  G C N  G Y+CSC  G+  H      +C D NEC     +C    C N  G
Sbjct: 2573 GNHR-CQHG-CQNIIGGYRCSCPQGYLQHYQ--WNQCVDENECL-SAHICGGASCHNTLG 2627

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            S+KC C +G+        C  I +     A          CS+ C+   G + C CP G
Sbjct: 2628 SYKCMCPAGFQYEQFSGGCQDINECGSSQA---------PCSYGCSNTEGGYLCGCPPG 2677

 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 71/282 (25%), Positives = 99/282 (35%), Gaps = 69/282 (24%)
 Frame = +1

Query: 142  RCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKN 321
            RC+N    Y C+C   +VL +  + CK   E +  + + A                 CKN
Sbjct: 2220 RCVNTYGSYECKCPTGYVLREDRRMCKDEDECEEGKHDCAEKQME------------CKN 2267

Query: 322  GRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGF 501
                     Y C C  G+Q   DG+ C D +EC T P IC+ G C+N+ GSY C C DGF
Sbjct: 2268 -----LIGMYICICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGF 2322

Query: 502  TIHNMPGGPKCYD--------------------------RNECSED-------------- 561
            T    P   +C D                          ++EC  D              
Sbjct: 2323 TA--SPTQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPF 2380

Query: 562  ------KSLCKNG------------------VC-----INIHGSFKCQCNSGYVASSNKQ 654
                  K LC +G                  VC     IN  GS+ C C +GY       
Sbjct: 2381 QGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECINDRGSYHCICKTGYTPDITGT 2440

Query: 655  DCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             C+ + + +              C+  C    G+++CSCP G
Sbjct: 2441 ACVDLNECNQAP---------KPCNFICKNTEGSYQCSCPKG 2473

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 66/263 (25%), Positives = 103/263 (39%), Gaps = 22/263 (8%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFNLKS 285
            E C  G C N +  ++C C   F L   G+ C+         +++  + +   S  + K 
Sbjct: 2022 EICALGTCSNTEGSFKCLCPDGFSLSSTGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQ 2081

Query: 286  QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDG--KICS--------------DIDE 417
            +C       C    C   G  +   C L   E  +   +IC               D+DE
Sbjct: 2082 EC-------C----CALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDE 2130

Query: 418  CTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINI 597
            C   P +C  G CIN+ GSY+C C  G+ +     G +C D +ECS     C NG C N+
Sbjct: 2131 CK-EPDVCKHGQCINTDGSYRCECPFGYILE----GNECVDTDECSVGNP-CGNGTCKNV 2184

Query: 598  HGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPY 777
             G F+C C  G+        C  I + +    +         C+  C    G+++C CP 
Sbjct: 2185 IGGFECTCEEGFEPGP-MMTCEDINECAQNPLL---------CAFRCVNTYGSYECKCPT 2234

Query: 778  GMESILDTGLCAPNSQIVDVQFD 846
            G     D  +C    +  + + D
Sbjct: 2235 GYVLREDRRMCKDEDECEEGKHD 2257

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 60/225 (26%), Positives = 92/225 (40%), Gaps = 10/225 (4%)
 Frame = +1

Query: 136 GGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLC 315
           GGRC+      RC C   F     G  C++  +Y+        S+   + Q    G    
Sbjct: 157 GGRCVAPN---RCACTYGFT----GPQCER--DYRTGPCFTVVSNQMCQGQLS--GIVCT 205

Query: 316 KNGRCIESGSSYECKCNL----------GFQESSDGKICSDIDECTTNPTICDRGTCINS 465
           K   C   G ++   C +          GF  +     C D+DEC   P +C  G CIN+
Sbjct: 206 KTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINT 265

Query: 466 PGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASS 645
            GS++C C  G   + +    KC D +ECS    +C  G C N   S+ C+C  G+  S 
Sbjct: 266 VGSFECKCPAGHKFNEV--SQKCEDIDECSTIPGICDGGECTNTVSSYFCKCPPGFYTSP 323

Query: 646 NKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
           +   CI ++    Y+A+ +      +CS+         +C C  G
Sbjct: 324 DGTRCIDVRPGYCYTALTN-----GRCSNQLPQSITKMQCCCDVG 363

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 68/253 (26%), Positives = 95/253 (37%), Gaps = 62/253 (24%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N++  Y+C C   + +D  G+ C    E   N                   S 
Sbjct: 734  CPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLN-------------------SL 774

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNP------------------- 432
            LC NG+C  +  S+ C C  GF    D K C DIDEC ++P                   
Sbjct: 775  LCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSS 834

Query: 433  --------TICD---RGTC----------INSPG----SYQCS----------------- 486
                    TIC    +GTC          IN  G    S  CS                 
Sbjct: 835  ESTLDPTKTICIETIKGTCWQTIIDGRCEININGATLKSQCCSSLGAAWGSPCTPCQVDP 894

Query: 487  -CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCI 663
             C  G++      G +C D +EC     +CKNG+C+N  GSFKCQC +G    +  + C+
Sbjct: 895  ICGKGYSRIK---GTQCEDIDECEVFPGVCKNGLCVNSKGSFKCQCPNGMTLDATGRICL 951

Query: 664  SIQDSSDYSAVDD 702
             I+  + +   +D
Sbjct: 952  DIRLETCFLRYED 964

 Score = 87.0 bits (214), Expect = 6e-17
 Identities = 63/214 (29%), Positives = 92/214 (42%), Gaps = 18/214 (8%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRT------EYKPNQMN-DAASSFNLKSQ 288
            C  G C+N    Y C C PDF L+     C          + +P   N D A S  +   
Sbjct: 1497 CISGNCVNTPGSYTCVCPPDFELNPTRVGCVDTRSGNCYLDVRPRGDNGDTACSNEIGVG 1556

Query: 289  CDKFGSFLCKNGR-----CIE----SGSSYECKC--NLGFQESSDGKICSDIDECTTNPT 435
              K  S  C  G+     C +    + S Y+  C    GF+ +    I  DIDEC   P 
Sbjct: 1557 VSK-ASCCCSLGKAWGTPCEQCPPVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPG 1615

Query: 436  ICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKC 615
            +C  G CIN+ GS+QC C  G+ ++       C D NEC E   +C  G C N  G++ C
Sbjct: 1616 LCQGGKCINTFGSFQCRCPTGYYLNE--DTRVCDDVNEC-ETPGICGPGTCYNTVGNYTC 1672

Query: 616  QCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYC 717
             C   Y+  +   +C+ ++ S  Y     +++ C
Sbjct: 1673 ICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTC 1706

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 52/165 (31%), Positives = 70/165 (42%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C N    + CEC   F LD+ G +C+   E                  C+  G+  C+
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDQSGASCEDVDE------------------CE--GNHRCQ 2578

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C      Y C C  G+ +      C D +EC  +  IC   +C N+ GSY+C C  G
Sbjct: 2579 HG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENEC-LSAHICGGASCHNTLGSYKCMCPAG 2636

Query: 499  FTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGY 633
            F      GG  C D NEC   ++ C  G C N  G + C C  GY
Sbjct: 2637 FQYEQFSGG--CQDINECGSSQAPCSYG-CSNTEGGYLCGCPPGY 2678

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 50/166 (30%), Positives = 73/166 (43%), Gaps = 20/166 (12%)
 Frame = +1

Query: 103 CSFSYYSEQC----KGGRCINMKNQYRCE-------CLPDFVLDKQGQACKKRTEYKPNQ 249
           C++ +   QC    + G C  + +   C+       C         G+A     E  P Q
Sbjct: 168 CTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227

Query: 250 MNDAASSF--NLKS-------QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKIC 402
            +     F  N+++       +C      LC+ G CI +  S+ECKC  G + +   + C
Sbjct: 228 PHPCRRGFIPNIRTGACQDVDECQAIPG-LCQGGNCINTVGSFECKCPAGHKFNEVSQKC 286

Query: 403 SDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYD 540
            DIDEC+T P ICD G C N+  SY C C  GF  +  P G +C D
Sbjct: 287 EDIDECSTIPGICDGGECTNTVSSYFCKCPPGF--YTSPDGTRCID 330

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 62/271 (22%), Positives = 98/271 (36%), Gaps = 35/271 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+GG+CIN    ++C C   + L++  + C    E                  C+  G  
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE------------------CETPG-- 1656

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDE--CTTN----PTICDRGTCINSPG 471
            +C  G C  +  +Y C C   + + + G  C D+    C  N       CD     N   
Sbjct: 1657 ICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTK 1716

Query: 472  SYQCSCYD-----------------------------GFTIHNMPGGPKCYDRNECSEDK 564
               C  Y+                             GF I    G P   D +EC E  
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLP--VDIDECREIP 1774

Query: 565  SLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAF 744
             +C+NGVCIN+ GSF+C+C  G+  +     C  I +  +      N++        C  
Sbjct: 1775 GVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAE--------CIN 1826

Query: 745  VNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
              G+++C C  G      TG C   ++  ++
Sbjct: 1827 TAGSYRCDCKPGYR-FTSTGQCNDRNECQEI 1856

 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 59/256 (23%), Positives = 93/256 (36%), Gaps = 29/256 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYK-PNQMNDAASSFNLKSQCDKFGS 306
            C   +C+     Y CE    FV     ++C    E   PN                    
Sbjct: 1415 CGNVQCLYAPGGYHCEYDMGFVPSADRKSCVDSDECSLPN-------------------- 1454

Query: 307  FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
             +C  G C      + C+C +G++    G  C+D++EC   PT C  G C+N+PGSY C 
Sbjct: 1455 -ICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLEPPT-CISGNCVNTPGSYTCV 1512

Query: 487  CYDGFTIHNMPGG------PKCY--DRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
            C   F ++    G        CY   R       + C N + + +     C C+ G    
Sbjct: 1513 CPPDFELNPTRVGCVDTRSGNCYLDVRPRGDNGDTACSNEIGVGV-SKASCCCSLGKAWG 1571

Query: 643  SNKQDCISIQDSSDYSA-------------------VDDNSKYCSKC-SHYCAFVNGTFK 762
            +  + C  + ++S+Y                     +D+  +    C    C    G+F+
Sbjct: 1572 TPCEQCPPV-NTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQ 1630

Query: 763  CSCPYGMESILDTGLC 810
            C CP G     DT +C
Sbjct: 1631 CRCPTGYYLNEDTRVC 1646

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 42/139 (30%), Positives = 56/139 (40%), Gaps = 10/139 (7%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQ-MNDAASSFN-----LK 282
            S  C  G C N    + CEC  +  LD     C +  +    Q + D     N     LK
Sbjct: 813  SSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTIIDGRCEININGATLK 872

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECK----CNLGFQESSDGKICSDIDECTTNPTICDRG 450
            SQC       C +           C+    C  G+     G  C DIDEC   P +C  G
Sbjct: 873  SQC-------CSSLGAAWGSPCTPCQVDPICGKGYSRIK-GTQCEDIDECEVFPGVCKNG 924

Query: 451  TCINSPGSYQCSCYDGFTI 507
             C+NS GS++C C +G T+
Sbjct: 925  LCVNSKGSFKCQCPNGMTL 943

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 49/194 (25%), Positives = 78/194 (40%), Gaps = 24/194 (12%)
 Frame = +1

Query: 301 GSFLCKNGRCIESG---SSYECKCNLGF---QESSDGK-------ICSDIDECTTNPTIC 441
           G  +C++G C+  G   +   C C  GF   Q   D +       + + + +   +  +C
Sbjct: 146 GQPVCESG-CLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVC 204

Query: 442 DRGTCINSPG---SYQCS--------CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVC 588
            +  C  + G    + C         C  GF I N+  G  C D +EC     LC+ G C
Sbjct: 205 TKTLCCATVGRAWGHPCEMCPAQPHPCRRGF-IPNIRTGA-CQDVDECQAIPGLCQGGNC 262

Query: 589 INIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCS 768
           IN  GSF+C+C +G+  +   Q C  I + S    + D  +        C     ++ C 
Sbjct: 263 INTVGSFECKCPAGHKFNEVSQKCEDIDECSTIPGICDGGE--------CTNTVSSYFCK 314

Query: 769 CPYGMESILDTGLC 810
           CP G  +  D   C
Sbjct: 315 CPPGFYTSPDGTRC 328
>sp|Q61554|FBN1_MOUSE Fibrillin-1 precursor
          Length = 2871

 Score =  136 bits (343), Expect = 7e-32
 Identities = 83/247 (33%), Positives = 106/247 (42%), Gaps = 30/247 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNL--KSQC-DKF 300
            C+GG C N +  YRCEC P   L     AC          +N+   S NL    +C +  
Sbjct: 1124 CRGGICHNTEGTYRCECPPGHQLSPNISACI--------DINECELSANLCPHGRCVNLI 1175

Query: 301  GSFLCK-----------------------NGRC----IESGSSYECKCNLGFQESSDGKI 399
            G + C                        NG C      S  SYEC C  GF    D + 
Sbjct: 1176 GKYQCACNPGYHPTHDRLFCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRS 1235

Query: 400  CSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKN 579
            C+DID+C  NP ICD G C N PG Y+C CYDGF          C D NEC  + ++C +
Sbjct: 1236 CTDIDQCEDNPNICDGGQCTNIPGEYRCLCYDGFMASE--DMKTCVDVNECDLNPNICLS 1293

Query: 580  GVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTF 759
            G C N  GSF C C+ GY     K  C      +D +  +  +  C + +  C    G+F
Sbjct: 1294 GTCENTKGSFICHCDMGYSGKKGKTGC------TDINECEIGAHNCGRHA-VCTNTAGSF 1346

Query: 760  KCSCPYG 780
            KCSC  G
Sbjct: 1347 KCSCSPG 1353

 Score =  132 bits (333), Expect = 1e-30
 Identities = 76/227 (33%), Positives = 104/227 (45%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ GRCI     YRCEC   F LD +G+                        +C+K    
Sbjct: 460  CQNGRCIPTPGSYRCECNKGFQLDIRGECIDV-------------------DECEKNP-- 498

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C  G CI +  SY C C  G+Q +     C DIDEC  N  IC+ G CIN+ GS+ C C
Sbjct: 499  -CTGGECINNQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVC 557

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
              GF  H    G  C D +EC    ++C NG+CIN  GSFKC C  G+  +S+ + C  I
Sbjct: 558  NAGF--HVSSEGKNCEDMDEC-RTPNMCPNGMCINEDGSFKCICKPGFQLASDGRYCKDI 614

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             +  +   +  N +        C   +G+++C C  G+   LD   C
Sbjct: 615  NE-CETPGICMNGR--------CVNTDGSYRCECFPGLAVGLDGRWC 652

 Score =  131 bits (329), Expect = 3e-30
 Identities = 79/244 (32%), Positives = 108/244 (44%), Gaps = 13/244 (5%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ G CINM   +RCEC   F  + +   C+   E                  C   G  
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDE------------------CQN-GPV 1817

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
              +N  CI +  SY C C  G++ +S G+ C+D +EC   P IC  G CI++ GS+ C C
Sbjct: 1818 CLRNAECINTAGSYRCDCKPGYRLTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCLC 1876

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
            + GF  +       C D NEC  D   C NG C N  GSF C+CN G++ S N  DCI +
Sbjct: 1877 HTGFKTNE--DQTMCLDINECERDA--CGNGTCRNTIGSFNCRCNHGFILSHNN-DCIDV 1931

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGM-------------ESILDTGLC 810
             + +       N   C   +  C    G+F+C C  G              E +LD G C
Sbjct: 1932 DECAT-----GNGNLCR--NGQCVNTVGSFQCRCNEGYEVAPDGRTCVDINECVLDPGKC 1984

Query: 811  APNS 822
            AP +
Sbjct: 1985 APGT 1988

 Score =  129 bits (324), Expect = 1e-29
 Identities = 69/236 (29%), Positives = 105/236 (44%), Gaps = 1/236 (0%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C N    ++C C   F LD + + C    E +                       
Sbjct: 1039 CTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECR-------------------ISPD 1079

Query: 310  LCKNGRCIESGSSYECKCNLGFQES-SDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
            LC  G+C+ +   +ECKC+ G++      K C DIDEC  +P +C  G C N+ G+Y+C 
Sbjct: 1080 LCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGICHNTEGTYRCE 1139

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  G  +   P    C D NEC    +LC +G C+N+ G ++C CN GY  + ++  C+ 
Sbjct: 1140 CPPGHQLS--PNISACIDINECELSANLCPHGRCVNLIGKYQCACNPGYHPTHDRLFCVD 1197

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVD 834
            I         D+ S     C  +C   +G+++CSC  G   + D   C    Q  D
Sbjct: 1198 I---------DECSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSCTDIDQCED 1244

 Score =  128 bits (322), Expect = 2e-29
 Identities = 70/235 (29%), Positives = 110/235 (46%), Gaps = 21/235 (8%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAA-----SSFNLK---- 282
            C  G+CI+    + C C   F  ++    C    E + +   +        SFN +    
Sbjct: 1860 CSHGQCIDTVGSFYCLCHTGFKTNEDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHG 1919

Query: 283  ------------SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT 426
                         +C      LC+NG+C+ +  S++C+CN G++ + DG+ C DI+EC  
Sbjct: 1920 FILSHNNDCIDVDECATGNGNLCRNGQCVNTVGSFQCRCNEGYEVAPDGRTCVDINECVL 1979

Query: 427  NPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGS 606
            +P  C  GTC N  GSY+C C  G+++ N     KC D +EC E+  +C  G C N  GS
Sbjct: 1980 DPGKCAPGTCQNLDGSYRCICPPGYSLQN----DKCEDIDECVEEPEICALGTCSNTEGS 2035

Query: 607  FKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
            FKC C  G+  SS+ + C  ++ S  Y+  +       KCS   +  +   +C C
Sbjct: 2036 FKCLCPEGFSWSSSGRRCQDLRMSYCYAKFEG-----GKCSSPKSRNHSKQECCC 2085

 Score =  127 bits (320), Expect = 3e-29
 Identities = 68/218 (31%), Positives = 99/218 (45%), Gaps = 1/218 (0%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ G C+N +  Y C C               +T Y P+    +    N  +Q  K  +F
Sbjct: 2413 CRNGECVNDRGSYHCIC---------------KTGYTPDITGTSCVDLNECNQAPKPCNF 2457

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +CKN     +  SY+C C  G+    DG+ C D+DEC T    C +  C+N+ G + C C
Sbjct: 2458 ICKN-----TEGSYQCSCPNGYILQEDGRSCKDLDECATKQHNC-QFLCVNTIGGFTCKC 2511

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLC-KNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
              GFT H+      C D NEC+ D +LC   G+C N  GSF C+C  G+    +   C  
Sbjct: 2512 PPGFTQHH----TACIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQSGASCED 2567

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            +          D  +   +C H C  + G ++CSCP G
Sbjct: 2568 V----------DECEGNHRCQHGCQNIIGGYRCSCPQG 2595

 Score =  123 bits (309), Expect = 6e-28
 Identities = 65/169 (38%), Positives = 90/169 (53%), Gaps = 1/169 (0%)
 Frame = +1

Query: 307 FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
           +LC+NGRCI +  SY C+CN GFQ    G+ C D+DEC  NP  C  G CIN+ GSY C 
Sbjct: 458 YLCQNGRCIPTPGSYRCECNKGFQLDIRGE-CIDVDECEKNP--CTGGECINNQGSYTCH 514

Query: 487 CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
           C  G+   +     +C D +EC ++  +C NG CIN  GSF C CN+G+  SS  ++C  
Sbjct: 515 CRAGY--QSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVSSEGKNCED 572

Query: 667 IQDSSDYSAVDDNSKYCSKCSH-YCAFVNGTFKCSCPYGMESILDTGLC 810
           +          D  +  + C +  C   +G+FKC C  G +   D   C
Sbjct: 573 M----------DECRTPNMCPNGMCINEDGSFKCICKPGFQLASDGRYC 611

 Score =  123 bits (309), Expect = 6e-28
 Identities = 62/201 (30%), Positives = 102/201 (50%), Gaps = 1/201 (0%)
 Frame = +1

Query: 211  QACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSD 390
            + C +   +    + +    F   ++C    S LC +G+C  +  S++C+C+ GF   S+
Sbjct: 1006 ELCPRGPGFATKDITNGKPFFKDINECKMIPS-LCTHGKCRNTIGSFKCRCDSGFALDSE 1064

Query: 391  GKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSL 570
             + C+DIDEC  +P +C RG C+N+PG ++C C +G+    M     C D +EC  D  L
Sbjct: 1065 ERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMM-MKNCMDIDECQRDPLL 1123

Query: 571  CKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFV 747
            C+ G+C N  G+++C+C  G+  S N   CI I +  + SA        + C H  C  +
Sbjct: 1124 CRGGICHNTEGTYRCECPPGHQLSPNISACIDINE-CELSA--------NLCPHGRCVNL 1174

Query: 748  NGTFKCSCPYGMESILDTGLC 810
             G ++C+C  G     D   C
Sbjct: 1175 IGKYQCACNPGYHPTHDRLFC 1195

 Score =  122 bits (305), Expect = 2e-27
 Identities = 79/279 (28%), Positives = 121/279 (43%), Gaps = 36/279 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF-GS 306
            C GG+C N+  +YRC C   F+  +  + C    E       D   +  L   C+   GS
Sbjct: 1249 CDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNEC------DLNPNICLSGTCENTKGS 1302

Query: 307  FLC--------KNGR---------------------CIESGSSYECKCNLGFQESSDGKI 399
            F+C        K G+                     C  +  S++C C+ G+    DG  
Sbjct: 1303 FICHCDMGYSGKKGKTGCTDINECEIGAHNCGRHAVCTNTAGSFKCSCSPGW--IGDGIK 1360

Query: 400  CSDIDECTTNPTICDR-GTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCK 576
            C+D+DEC+    +C +   C N+ GSY+C C DG+T      G  C D +ECSE+ +LC 
Sbjct: 1361 CTDLDECSNGTHMCSQHADCKNTMGSYRCLCKDGYT----GDGFTCTDLDECSENLNLCG 1416

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAF---- 744
            NG C+N  G ++C+C+ G+V S++ + C  I + S                + C F    
Sbjct: 1417 NGQCLNAPGGYRCECDMGFVPSADGKACEDIDECS--------------LPNICVFGTCH 1462

Query: 745  -VNGTFKCSCPYGMESILDTGLCAPNSQIVDVQFDIPNN 858
             + G F+C C  G E     G C   ++ +D    I  N
Sbjct: 1463 NLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGN 1501

 Score =  116 bits (290), Expect = 9e-26
 Identities = 76/294 (25%), Positives = 113/294 (38%), Gaps = 58/294 (19%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKK-------RTEYKPNQMNDAASSFNL-KS 285
            C  G C N    Y C C PD++    G  C         R  Y  NQ  D    FN+ K 
Sbjct: 1658 CGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSICYRNYYADNQTCDGELLFNMTKK 1717

Query: 286  QC----------------------DKFGSF----------------------------LC 315
             C                      D+F +                             +C
Sbjct: 1718 MCCCSYNIRRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVC 1777

Query: 316  KNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYD 495
            +NG CI    S+ C+C +GF  +    +C DIDEC   P       CIN+ GSY+C C  
Sbjct: 1778 ENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCLRNAECINTAGSYRCDCKP 1837

Query: 496  GFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQD 675
            G+    +    +C DRNEC E  ++C +G CI+  GSF C C++G+  + ++  C+ I +
Sbjct: 1838 GY---RLTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNEDQTMCLDINE 1894

Query: 676  SSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
                +  +            C    G+F C C +G        + + N+  +DV
Sbjct: 1895 CERDACGNGT----------CRNTIGSFNCRCNHGF-------ILSHNNDCIDV 1931

 Score =  115 bits (288), Expect = 2e-25
 Identities = 65/218 (29%), Positives = 96/218 (44%), Gaps = 26/218 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQ------------------------GQACKKRTEY 237
            C+ G+CIN    YRCEC   ++L+                          G  C     +
Sbjct: 2137 CRHGQCINTDGSYRCECPFGYILEGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGF 2196

Query: 238  KPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDE 417
            +P  M          ++C +    LC   RC+ +  SYECKC +G+    D ++C D DE
Sbjct: 2197 EPGPMMTCEDI----NECAQ-NPLLCAF-RCVNTYGSYECKCPVGYVLREDRRMCKDEDE 2250

Query: 418  CTTNPTICDRGT--CINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCI 591
            C      C      C N  G+Y C C  G+     P G  C D NEC     +C+NG C+
Sbjct: 2251 CAEGKHDCTEKQMECKNLIGTYMCICGPGY--QRRPDGEGCIDENECQTKPGICENGRCL 2308

Query: 592  NIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDN 705
            N  GS+ C+CN G+ AS  + +C+  ++   +S V +N
Sbjct: 2309 NTLGSYTCECNDGFTASPTQDECLDNREGYCFSEVFEN 2346

 Score =  115 bits (287), Expect = 2e-25
 Identities = 66/215 (30%), Positives = 98/215 (45%), Gaps = 3/215 (1%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNG 324
            C N    YRC C   +  D  G  C          +++ + + NL           C NG
Sbjct: 1380 CKNTMGSYRCLCKDGYTGD--GFTC--------TDLDECSENLNL-----------CGNG 1418

Query: 325  RCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFT 504
            +C+ +   Y C+C++GF  S+DGK C DIDEC+  P IC  GTC N PG ++C C  G+ 
Sbjct: 1419 QCLNAPGGYRCECDMGFVPSADGKACEDIDECSL-PNICVFGTCHNLPGLFRCECEIGYE 1477

Query: 505  IHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSD 684
            +     G  C D NEC  D + C +G C+N  GS+ C C+  +  +  +  C+  +  + 
Sbjct: 1478 LDR--SGGNCTDVNECL-DPTTCISGNCVNTPGSYTCDCSPDFELNPTRVGCVDTRSGNC 1534

Query: 685  YSAV---DDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            Y  +    DN    + CS+          C C  G
Sbjct: 1535 YLNIRPRGDNGD--TACSNEIGVGVSKASCCCSLG 1567

 Score =  114 bits (284), Expect = 5e-25
 Identities = 72/241 (29%), Positives = 95/241 (39%), Gaps = 50/241 (20%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQG--------------------------------Q 213
            C  GRC+N    YRCEC P   +   G                                +
Sbjct: 623  CMNGRCVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSSCYGGYRRGQCVKPLFGAVTKSE 682

Query: 214  ACKKRTEY---KPNQMNDAASSFNLKSQCDKFGSF---------------LCKNGRCIES 339
             C   TEY   +P Q   A +S   ++ C                     +C NG C   
Sbjct: 683  CCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGTDINECALDPDICPNGICENL 742

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMP 519
              +Y+C CN G++    GK C DI+EC  N  +CD G C N+PGS+ C+C  GF     P
Sbjct: 743  RGTYKCICNSGYEVDITGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFVY--KP 800

Query: 520  GGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVD 699
                C D +EC  + S C NGVC N  GSF C+C+        K  CI     + +  V 
Sbjct: 801  DLKTCEDIDEC--ESSPCINGVCKNSPGSFICECSPESTLDPTKTICIETIKGTCWQTVI 858

Query: 700  D 702
            D
Sbjct: 859  D 859

 Score =  105 bits (261), Expect = 2e-22
 Identities = 71/258 (27%), Positives = 98/258 (37%), Gaps = 31/258 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    ++C C P F L   G+ CK   E                  C+  G  
Sbjct: 582  CPNGMCINEDGSFKCICKPGFQLASDGRYCKDINE------------------CETPG-- 621

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCI---------- 459
            +C NGRC+ +  SY C+C  G     DG+ C D    ++      RG C+          
Sbjct: 622  ICMNGRCVNTDGSYRCECFPGLAVGLDGRWCVDTHMRSSCYGGYRRGQCVKPLFGAVTKS 681

Query: 460  --------------------NSPGSYQCSCYDGFTIHNMPGGPKC-YDRNECSEDKSLCK 576
                                 +   YQ  C  G      PG      D NEC+ D  +C 
Sbjct: 682  ECCCASTEYAFGEPCQPCPAQNSAEYQALCSSG------PGMTSAGTDINECALDPDICP 735

Query: 577  NGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGT 756
            NG+C N+ G++KC CNSGY      ++C+ I +    S + DN +        C    G+
Sbjct: 736  NGICENLRGTYKCICNSGYEVDITGKNCVDINECVLNSLLCDNGQ--------CRNTPGS 787

Query: 757  FKCSCPYGMESILDTGLC 810
            F C+CP G     D   C
Sbjct: 788  FVCTCPKGFVYKPDLKTC 805

 Score =  103 bits (256), Expect = 8e-22
 Identities = 65/233 (27%), Positives = 91/233 (39%), Gaps = 21/233 (9%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMN------DAASSFNLK-------- 282
            C N +  Y+C C   ++L + G++CK   E    Q N      +    F  K        
Sbjct: 2459 CKNTEGSYQCSCPNGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQH 2518

Query: 283  -------SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTIC 441
                   ++C    +     G C  +  S+ C+C  GF     G  C D+DEC  N   C
Sbjct: 2519 HTACIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHR-C 2577

Query: 442  DRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
              G C N  G Y+CSC  G+  H      +C D NEC     +C    C N  GS+KC C
Sbjct: 2578 QHG-CQNIIGGYRCSCPQGYLQHYQ--WNQCVDENECL-SAHVCGGASCHNTLGSYKCMC 2633

Query: 622  NSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             +G+        C  I +     A          CS+ C+   G + C CP G
Sbjct: 2634 PAGFQYEQFSGGCQDINECGSSQA---------PCSYGCSNTEGGYLCGCPPG 2677

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 60/214 (28%), Positives = 90/214 (42%), Gaps = 18/214 (8%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQC-DKFGS 306
            C  G C+N    Y C+C PDF L+     C   T      +N      N  + C ++ G 
Sbjct: 1497 CISGNCVNTPGSYTCDCSPDFELNPTRVGCVD-TRSGNCYLNIRPRGDNGDTACSNEIGV 1555

Query: 307  FLCKNGRCIESGSSYECKCNL-----------------GFQESSDGKICSDIDECTTNPT 435
             + K   C   G ++   C L                 GF+ +    I  DIDEC   P 
Sbjct: 1556 GVSKASCCCSLGKAWGTPCELCPSVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPG 1615

Query: 436  ICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKC 615
            +C  G CIN+ GS+QC C  G+ ++       C D NEC E   +C  G C N  G++ C
Sbjct: 1616 LCQGGKCINTFGSFQCRCPTGYYLNE--DTRVCDDVNEC-ETPGICGPGTCYNTVGNYTC 1672

Query: 616  QCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYC 717
             C   Y+  +   +C+ ++ S  Y     +++ C
Sbjct: 1673 ICPPDYMQVNGGNNCMDMRRSICYRNYYADNQTC 1706

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 66/256 (25%), Positives = 101/256 (39%), Gaps = 29/256 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYK-PNQMNDAASSFNLKSQCDKFGS 306
            C  G+C+N    YRCEC   FV    G+AC+   E   PN                    
Sbjct: 1415 CGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPN-------------------- 1454

Query: 307  FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
             +C  G C      + C+C +G++    G  C+D++EC  +PT C  G C+N+PGSY C 
Sbjct: 1455 -ICVFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNEC-LDPTTCISGNCVNTPGSYTCD 1512

Query: 487  CYDGFTIHNMPGG------PKCY--DRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
            C   F ++    G        CY   R       + C N + + +     C C+ G    
Sbjct: 1513 CSPDFELNPTRVGCVDTRSGNCYLNIRPRGDNGDTACSNEIGVGV-SKASCCCSLGKAWG 1571

Query: 643  SNKQDCISIQDSSDYSA-------------------VDDNSKYCSKC-SHYCAFVNGTFK 762
            +  + C S+ ++S+Y                     +D+  +    C    C    G+F+
Sbjct: 1572 TPCELCPSV-NTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQ 1630

Query: 763  CSCPYGMESILDTGLC 810
            C CP G     DT +C
Sbjct: 1631 CRCPTGYYLNEDTRVC 1646

 Score = 90.5 bits (223), Expect = 6e-18
 Identities = 65/263 (24%), Positives = 102/263 (38%), Gaps = 22/263 (8%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKR------TEYKPNQMNDAASSFNLKS 285
            E C  G C N +  ++C C   F     G+ C+         +++  + +   S  + K 
Sbjct: 2022 EICALGTCSNTEGSFKCLCPEGFSWSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQ 2081

Query: 286  QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDG--KICS--------------DIDE 417
            +C       C    C   G  +   C L   E  +   +IC               D+DE
Sbjct: 2082 EC-------C----CALKGEGWGDPCELCPTEPDEAFRQICPFGSGIIVGPDDSAVDMDE 2130

Query: 418  CTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINI 597
            C   P +C  G CIN+ GSY+C C  G+ +     G +C D +ECS     C NG C N+
Sbjct: 2131 CK-EPDVCRHGQCINTDGSYRCECPFGYILE----GNECVDTDECSVGNP-CGNGTCKNV 2184

Query: 598  HGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPY 777
             G F+C C  G+        C  I + +    +         C+  C    G+++C CP 
Sbjct: 2185 IGGFECTCEEGFEPGP-MMTCEDINECAQNPLL---------CAFRCVNTYGSYECKCPV 2234

Query: 778  GMESILDTGLCAPNSQIVDVQFD 846
            G     D  +C    +  + + D
Sbjct: 2235 GYVLREDRRMCKDEDECAEGKHD 2257

 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 59/225 (26%), Positives = 92/225 (40%), Gaps = 10/225 (4%)
 Frame = +1

Query: 136 GGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLC 315
           GGRC+      RC C   F     G  C++  +Y+        S+   + Q    G    
Sbjct: 157 GGRCVAPN---RCACTYGFT----GPQCER--DYRTGPCFTVVSNQMCQGQLS--GIVCT 205

Query: 316 KNGRCIESGSSYECKCNL----------GFQESSDGKICSDIDECTTNPTICDRGTCINS 465
           K   C   G ++   C +          GF  +     C D+DEC   P +C  G CIN+
Sbjct: 206 KTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGMCQGGNCINT 265

Query: 466 PGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASS 645
            GS++C C  G   + +    KC D +ECS    +C  G C N   S+ C+C  G+  S 
Sbjct: 266 VGSFECKCPAGHKFNEV--SQKCEDIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYTSP 323

Query: 646 NKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
           +   C+ ++    Y+A+ +      +CS+         +C C  G
Sbjct: 324 DGTRCVDVRPGYCYTALAN-----GRCSNQLPQSITKMQCCCDLG 363

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 53/176 (30%), Positives = 70/176 (39%)
 Frame = +1

Query: 142  RCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKN 321
            RC+N    Y C+C   +VL +  + CK   E               K  C +      K 
Sbjct: 2220 RCVNTYGSYECKCPVGYVLREDRRMCKDEDECAEG-----------KHDCTE------KQ 2262

Query: 322  GRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGF 501
              C     +Y C C  G+Q   DG+ C D +EC T P IC+ G C+N+ GSY C C DGF
Sbjct: 2263 MECKNLIGTYMCICGPGYQRRPDGEGCIDENECQTKPGICENGRCLNTLGSYTCECNDGF 2322

Query: 502  TIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
            T    P   +C D  E          G C +      CQ  S       K +C  +
Sbjct: 2323 TA--SPTQDECLDNRE----------GYCFSEVFENMCQIGSSNRNPVTKSECCCV 2366

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 20/166 (12%)
 Frame = +1

Query: 103 CSFSYYSEQC----KGGRCINMKNQYRCE-------CLPDFVLDKQGQACKKRTEYKPNQ 249
           C++ +   QC    + G C  + +   C+       C         G+A     E  P Q
Sbjct: 168 CTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227

Query: 250 MNDAASSF--NLKS-------QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKIC 402
            +     F  N+++       +C      +C+ G CI +  S+ECKC  G + +   + C
Sbjct: 228 PHPCRRGFIPNIRTGACQDVDECQAIPG-MCQGGNCINTVGSFECKCPAGHKFNEVSQKC 286

Query: 403 SDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYD 540
            DIDEC+T P +CD G C N+  SY C C  GF  +  P G +C D
Sbjct: 287 EDIDECSTIPGVCDGGECTNTVSSYFCKCPPGF--YTSPDGTRCVD 330

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 63/271 (23%), Positives = 99/271 (36%), Gaps = 35/271 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+GG+CIN    ++C C   + L++  + C    E                  C+  G  
Sbjct: 1617 CQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE------------------CETPG-- 1656

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDE--CTTN----PTICDRGTCINSPG 471
            +C  G C  +  +Y C C   + + + G  C D+    C  N       CD     N   
Sbjct: 1657 ICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSICYRNYYADNQTCDGELLFNMTK 1716

Query: 472  SYQCSCYD-----------------------------GFTIHNMPGGPKCYDRNECSEDK 564
               C  Y+                             GF I    G P   D +EC E  
Sbjct: 1717 KMCCCSYNIRRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLP--VDIDECREIP 1774

Query: 565  SLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAF 744
             +C+NGVCIN+ GSF+C+C  G+  +     C  I +         N   C + +  C  
Sbjct: 1775 GVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDEC-------QNGPVCLRNAE-CIN 1826

Query: 745  VNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
              G+++C C  G   +  TG C   ++  ++
Sbjct: 1827 TAGSYRCDCKPGYR-LTSTGQCNDRNECQEI 1856

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 40/123 (32%), Positives = 62/123 (50%)
 Frame = +1

Query: 412 DECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCI 591
           D C     +C  G CI +PGSY+C C  GF + ++ G  +C D +EC  +K+ C  G CI
Sbjct: 451 DYCQLVRYLCQNGRCIPTPGSYRCECNKGFQL-DIRG--ECIDVDEC--EKNPCTGGECI 505

Query: 592 NIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
           N  GS+ C C +GY ++  + +C  I +      + +N +        C   +G+F C C
Sbjct: 506 NNQGSYTCHCRAGYQSTLTRTECRDIDECLQNGRICNNGR--------CINTDGSFHCVC 557

Query: 772 PYG 780
             G
Sbjct: 558 NAG 560

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 65/286 (22%), Positives = 103/286 (36%), Gaps = 56/286 (19%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEY-------KPNQMNDAASSFNL--- 279
            C+ G+C+N    ++C C   + +   G+ C    E         P    +   S+     
Sbjct: 1942 CRNGQCVNTVGSFQCRCNEGYEVAPDGRTCVDINECVLDPGKCAPGTCQNLDGSYRCICP 2001

Query: 280  ------KSQCDKFGSF-----LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT 426
                    +C+          +C  G C  +  S++C C  GF  SS G+ C D+     
Sbjct: 2002 PGYSLQNDKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSWSSSGRRCQDLRMSYC 2061

Query: 427  NPTICDRGTCINSPGS-----YQCSCYD-----GFTIHNMPGGP---------------- 528
                 + G C +SP S      +C C       G      P  P                
Sbjct: 2062 YAKF-EGGKC-SSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPFGSGIIV 2119

Query: 529  ----KCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAV 696
                   D +EC E   +C++G CIN  GS++C+C  GY+   N  +C+   + S  +  
Sbjct: 2120 GPDDSAVDMDECKEP-DVCRHGQCINTDGSYRCECPFGYILEGN--ECVDTDECSVGNPC 2176

Query: 697  DDNSKYCSKCSHYCAFVNGTFKCSCPYGME-----SILDTGLCAPN 819
             + +         C  V G F+C+C  G E     +  D   CA N
Sbjct: 2177 GNGT---------CKNVIGGFECTCEEGFEPGPMMTCEDINECAQN 2213

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 54/215 (25%), Positives = 82/215 (38%), Gaps = 30/215 (13%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQM-----NDAASSFNLK------- 282
            G C N    + CEC   F LD+ G +C+   E + N        +    +          
Sbjct: 2539 GICQNTPGSFTCECQRGFSLDQSGASCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQ 2598

Query: 283  ----SQC----DKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTI 438
                +QC    +   + +C    C  +  SY+C C  GFQ       C DI+EC ++   
Sbjct: 2599 HYQWNQCVDENECLSAHVCGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSSQAP 2658

Query: 439  CDRGTCINSPGSYQCSCYDGF----TIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGS 606
            C  G C N+ G Y C C  G+      H + G        E      +  N   ++    
Sbjct: 2659 CSYG-CSNTEGGYLCGCPPGYFRIGQGHCLSGMGMGRGAPEPPASSEMDDNS--LSPEAC 2715

Query: 607  FKCQCNSGYV------ASSNKQDCISIQDSSDYSA 693
            ++C+ N GY        S+N+ D   IQD S+  A
Sbjct: 2716 YECKIN-GYPKRGRKRRSTNETDASDIQDGSEMEA 2749

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 49/194 (25%), Positives = 78/194 (40%), Gaps = 24/194 (12%)
 Frame = +1

Query: 301 GSFLCKNGRCIESG---SSYECKCNLGF---QESSDGK-------ICSDIDECTTNPTIC 441
           G  +C++G C+  G   +   C C  GF   Q   D +       + + + +   +  +C
Sbjct: 146 GQPVCESG-CLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVVSNQMCQGQLSGIVC 204

Query: 442 DRGTCINSPG---SYQCS--------CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVC 588
            +  C  + G    + C         C  GF I N+  G  C D +EC     +C+ G C
Sbjct: 205 TKTLCCATVGRAWGHPCEMCPAQPHPCRRGF-IPNIRTGA-CQDVDECQAIPGMCQGGNC 262

Query: 589 INIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCS 768
           IN  GSF+C+C +G+  +   Q C  I + S    V D  +        C     ++ C 
Sbjct: 263 INTVGSFECKCPAGHKFNEVSQKCEDIDECSTIPGVCDGGE--------CTNTVSSYFCK 314

Query: 769 CPYGMESILDTGLC 810
           CP G  +  D   C
Sbjct: 315 CPPGFYTSPDGTRC 328
>sp|O77469|FBLN1_CAEEL Fibulin-1 precursor
          Length = 728

 Score =  134 bits (338), Expect = 3e-31
 Identities = 78/223 (34%), Positives = 106/223 (47%), Gaps = 8/223 (3%)
 Frame = +1

Query: 130 CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
           C    CIN+   Y+C+C P +                  + NDA        +C KF   
Sbjct: 399 CGSMECINLPGTYKCKCGPGY------------------EFNDAKKRCEDVDECIKFAGH 440

Query: 310 LCK-NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
           +C  +  CI +  S+ECKC  GFQ +SDG+ C D++ECTT    C++  C+N PGSYQC 
Sbjct: 441 VCDLSAECINTIGSFECKCKPGFQLASDGRRCEDVNECTTGIAACEQ-KCVNIPGSYQCI 499

Query: 487 CYDGFTIHNMPGGPKCYDRNECS----EDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQ 654
           C  GF +   P G KC D +ECS        LC  G CIN  GS+ CQC  GY    + +
Sbjct: 500 CDRGFALG--PDGTKCEDIDECSIWAGSGNDLCMGG-CINTKGSYLCQCPPGYKIQPDGR 556

Query: 655 DCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKC---SCP 774
            C+ +    D  A+ +    C+     C    G+FKC    CP
Sbjct: 557 TCVDV----DECAMGE----CAGSDKVCVNTLGSFKCHSIDCP 591

 Score =  103 bits (256), Expect = 8e-22
 Identities = 63/227 (27%), Positives = 104/227 (45%), Gaps = 2/227 (0%)
 Frame = +1

Query: 136 GGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLC 315
           G  C+N    +RC+        ++G  C    E     +N A       ++C +    +C
Sbjct: 356 GEECVNTPGSFRCQ--------QKGNLCAHGYE-----VNGATGFCEDVNECQQG---VC 399

Query: 316 KNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT-NPTICD-RGTCINSPGSYQCSC 489
            +  CI    +Y+CKC  G++ +   K C D+DEC      +CD    CIN+ GS++C C
Sbjct: 400 GSMECINLPGTYKCKCGPGYEFNDAKKRCEDVDECIKFAGHVCDLSAECINTIGSFECKC 459

Query: 490 YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
             GF + +   G +C D NEC+   + C+   C+NI GS++C C+ G+    +   C  I
Sbjct: 460 KPGFQLAS--DGRRCEDVNECTTGIAACEQ-KCVNIPGSYQCICDRGFALGPDGTKCEDI 516

Query: 670 QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
            + S ++   ++      C   C    G++ C CP G +   D   C
Sbjct: 517 DECSIWAGSGND-----LCMGGCINTKGSYLCQCPPGYKIQPDGRTC 558

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 12/182 (6%)
 Frame = +1

Query: 301 GSFLCKNGRC----IESGSSYECK---CNLGFQESSDGKICSDIDECTTNPTICDRGTCI 459
           GS+ C   +C    +++  + EC    C  G+   +   +C+DIDEC T         C+
Sbjct: 303 GSYRCDAKKCGDGELQNPMTGECTSITCPNGYYPKNG--MCNDIDECVTGHNCGAGEECV 360

Query: 460 NSPGSYQCS-----CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCN 624
           N+PGS++C      C  G+ ++   G   C D NEC +   +C +  CIN+ G++KC+C 
Sbjct: 361 NTPGSFRCQQKGNLCAHGYEVNGATG--FCEDVNECQQ--GVCGSMECINLPGTYKCKCG 416

Query: 625 SGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTG 804
            GY  +  K+ C  + +   ++       +    S  C    G+F+C C  G +   D  
Sbjct: 417 PGYEFNDAKKRCEDVDECIKFAG------HVCDLSAECINTIGSFECKCKPGFQLASDGR 470

Query: 805 LC 810
            C
Sbjct: 471 RC 472

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 54/232 (23%), Positives = 78/232 (33%), Gaps = 59/232 (25%)
 Frame = +1

Query: 292 DKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRG-TCINSP 468
           D+  S  C++      G   EC C  GF  + DG  C D +EC T  + C +   C+N+ 
Sbjct: 157 DRCASSHCEHLCHDRGGEKVECSCRSGFDLAPDGMACVDRNECLTRQSPCTQSEDCVNTI 216

Query: 469 GSYQCS---------CYDGFTIHNMP------------------------GGP------- 528
           G Y C           +    I N P                        G P       
Sbjct: 217 GGYICQRRISRLVPHRHRANRIGNAPRRMRDDPYSRAGEYREASQANTEFGCPMGWLFQH 276

Query: 529 -KCYDRNECSEDKSLC-KNGVCINIHGSFKC---QCNSGYVASSNKQDCISIQDSSDYSA 693
             C D +EC+     C     C N  GS++C   +C  G + +    +C SI   + Y  
Sbjct: 277 GHCVDVDECNLGSHDCGPLYQCRNTQGSYRCDAKKCGDGELQNPMTGECTSITCPNGYYP 336

Query: 694 VDDNSKYCSKC--------SHYCAFVNGTFKCS-----CPYGMESILDTGLC 810
            +       +C           C    G+F+C      C +G E    TG C
Sbjct: 337 KNGMCNDIDECVTGHNCGAGEECVNTPGSFRCQQKGNLCAHGYEVNGATGFC 388
>sp|Q75N90|FBN3_HUMAN Fibrillin-3 precursor
          Length = 2809

 Score =  134 bits (338), Expect = 3e-31
 Identities = 75/237 (31%), Positives = 102/237 (43%), Gaps = 23/237 (9%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPN-------QMNDAASSFNL--- 279
            C+GG C N    Y+C+C P   L  +G AC+   E   +       Q  +   +F     
Sbjct: 1082 CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCH 1141

Query: 280  --------KSQCDKFGSFLCKNG----RCIESGSSYECKCNLGFQESSDGKICSDIDECT 423
                    +  C        +NG     CI +  SY C C  G+    DG+ C+D+DEC 
Sbjct: 1142 AGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADVDECE 1201

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
             NP +CD+G C N PG ++C CYDGF     P    C D +EC  +  +C +G C N  G
Sbjct: 1202 ENPRVCDQGHCTNMPGGHRCLCYDGFMA--TPDMRTCVDVDECDLNPHICLHGDCENTKG 1259

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVNGTFKCSC 771
            SF C C  GY+       C      SD    +     C   SH  C  + G+F C C
Sbjct: 1260 SFVCHCQLGYMVRKGATGC------SDVDECEVGGHNCD--SHASCLNIPGSFSCRC 1308

 Score =  132 bits (331), Expect = 2e-30
 Identities = 69/232 (29%), Positives = 105/232 (45%)
 Frame = +1

Query: 115  YYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCD 294
            +++  C  GRC+   + YRCEC   +  D +G+                          D
Sbjct: 414  HFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECI----------------------DVD 451

Query: 295  KFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGS 474
            +  S  C +G C+    +Y C+C  GFQ +   + C D+DEC  +  +C  G C+N+ GS
Sbjct: 452  ECTSSPCHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGS 511

Query: 475  YQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQ 654
            +QC C  GF +   P G  C D NEC+   ++C NGVC+N  GSF C C  G++ +    
Sbjct: 512  FQCVCNAGFEL--SPDGKNCVDHNECA-TSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGH 568

Query: 655  DCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             C+ I D      +  N         +C    G+F+C C  G+    D  +C
Sbjct: 569  YCMDI-DECQTPGICVNG--------HCTNTEGSFRCQCLGGLAVGTDGRVC 611

 Score =  132 bits (331), Expect = 2e-30
 Identities = 68/229 (29%), Positives = 104/229 (45%), Gaps = 1/229 (0%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N    + C C   F LD Q + C    E +                       
Sbjct: 997  CTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECR-------------------ISPD 1037

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSD-GKICSDIDECTTNPTICDRGTCINSPGSYQCS 486
            LC  G C+ +  S+EC+C  G++      K C D+DEC  +P +C  GTC N+ GSY+C 
Sbjct: 1038 LCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQ 1097

Query: 487  CYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
            C  G  +     G  C D +ECS    LC +G C+N+ G+F+C C++G+ ++ ++Q C+ 
Sbjct: 1098 CPPGHEL--TAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVD 1155

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCA 813
            I +    +           C  +C    G+++CSC  G   + D   CA
Sbjct: 1156 INECRVQN---------GGCDVHCINTEGSYRCSCGQGYSLMPDGRACA 1195

 Score =  127 bits (319), Expect = 4e-29
 Identities = 68/214 (31%), Positives = 100/214 (46%), Gaps = 1/214 (0%)
 Frame = +1

Query: 172  CECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSY 351
            CE  PD    +    C +   +           +   ++C  F   LC +G C  +  S+
Sbjct: 951  CEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPG-LCTHGTCRNTVGSF 1009

Query: 352  ECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPK 531
             C C  GF   +  + C+DIDEC  +P +C +GTC+N+PGS++C C+ G+    M     
Sbjct: 1010 HCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFML-MKN 1068

Query: 532  CYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSK 711
            C D +EC+ D  LC+ G C N  GS+KCQC  G+  ++    C           +D+ S 
Sbjct: 1069 CMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTAC---------EDIDECSL 1119

Query: 712  YCSKCSH-YCAFVNGTFKCSCPYGMESILDTGLC 810
                C H  C  V G F+CSC  G +S  D   C
Sbjct: 1120 SDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGC 1153

 Score =  125 bits (313), Expect = 2e-28
 Identities = 65/195 (33%), Positives = 97/195 (49%)
 Frame = +1

Query: 196 LDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGF 375
           L+  G   +      P   N   ++ N      +  + LC NGRC+ + SSY C+CN+G+
Sbjct: 380 LNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGY 439

Query: 376 QESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECS 555
            +   G+ C D+DECT++P  C  G C+N PG+Y C CY GF     P    C D +EC 
Sbjct: 440 TQDVRGE-CIDVDECTSSP--CHHGDCVNIPGTYHCRCYPGF--QATPTRQACVDVDECI 494

Query: 556 EDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHY 735
               LC  G C+N  GSF+C CN+G+  S + ++C+   + +        S  C   +  
Sbjct: 495 VSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECA-------TSTMC--VNGV 545

Query: 736 CAFVNGTFKCSCPYG 780
           C   +G+F C C  G
Sbjct: 546 CLNEDGSFSCLCKPG 560

 Score =  123 bits (309), Expect = 6e-28
 Identities = 67/216 (31%), Positives = 95/216 (43%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFG 303
            + C  G C N+   Y C C P FV+   G                         +C    
Sbjct: 1854 QPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDF-------------------DECTTLV 1894

Query: 304  SFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQC 483
              +C+ G C+ +  S+ C C  GF+ ++DGK C D +EC +    C  GTC N  GS++C
Sbjct: 1895 GQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRC 1954

Query: 484  SCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCI 663
             C  GF + +      C D +ECSE+ +LC  G C N  GSF+C C  G+V S N   C 
Sbjct: 1955 ICPPGFQVQS----DHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCF 2010

Query: 664  SIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
              + S  ++  +       KCS   AF     +C C
Sbjct: 2011 DTRQSFCFTRFE-----AGKCSVPKAFNTTKTRCCC 2041

 Score =  121 bits (303), Expect = 3e-27
 Identities = 71/218 (32%), Positives = 104/218 (47%), Gaps = 4/218 (1%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYK--PNQMNDAASSFNLKSQCDKFGSFLCK 318
            CIN+   YRC+C   + L   G AC  R E +  PN                     +C 
Sbjct: 1780 CINIPGSYRCKCTRGYKLSPGG-ACVGRNECREIPN---------------------VCS 1817

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C+++  SY C C+ GFQ S+D  +C DIDEC   P  C  GTC N  GSY C C+ G
Sbjct: 1818 HGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQP--CGNGTCKNIIGSYNCLCFPG 1875

Query: 499  FTI-HNMPGGPKCYDRNECSE-DKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQ 672
            F + HN      C D +EC+     +C+ G C+N  GSF C C  G+  +++ ++C+   
Sbjct: 1876 FVVTHN----GDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTN 1931

Query: 673  DSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
            +    +        C   +  C  + G+F+C CP G +
Sbjct: 1932 ECLSLAGT------CLPGT--CQNLEGSFRCICPPGFQ 1961

 Score =  119 bits (298), Expect = 1e-26
 Identities = 68/233 (29%), Positives = 98/233 (42%), Gaps = 1/233 (0%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    +RC C   +  D     C    E                SQ  K  +F
Sbjct: 2374 CAHGECINSLGSFRCHCQAGYTPDATATTCLDMDEC---------------SQVPKPCTF 2418

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            LCKN +      S+ C C  G+    DG+ C D+DECT+    C +  C+N+ G++ C C
Sbjct: 2419 LCKNTK-----GSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC-QFLCVNTVGAFTCRC 2472

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLC-KNGVCINIHGSFKCQCNSGYVASSNKQDCIS 666
              GFT H+      C+D +ECS     C  +G C N  GSF+C+C+ G+   S+   C  
Sbjct: 2473 PPGFTQHHQ----ACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCED 2528

Query: 667  IQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQ 825
            + +               +C H C    G ++CSCP G         C   ++
Sbjct: 2529 VNECDG----------PHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQCVDENE 2571

 Score =  116 bits (291), Expect = 7e-26
 Identities = 64/214 (29%), Positives = 92/214 (42%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C+N+   YRC C   F  D  G  C+ R E   N                     LC 
Sbjct: 1336 GDCLNVPGSYRCTCRQGFAGD--GFFCEDRDECAENVD-------------------LCD 1374

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            NG+C+ +   Y C+C +GF  + D + C D+DEC     +C  G+C N PG ++C C  G
Sbjct: 1375 NGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQG-NLCAFGSCENLPGMFRCICNGG 1433

Query: 499  FTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDS 678
            + +    GG  C D NEC++  + C NGVCIN  GS+ C C   +  + +   C+  +  
Sbjct: 1434 YELDR--GGGNCTDINECADPVN-CINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAG 1490

Query: 679  SDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
            + +    D       CS           C C  G
Sbjct: 1491 NCFLETHDRGDSGISCSAEIGVGVTRASCCCSLG 1524

 Score =  115 bits (287), Expect = 2e-25
 Identities = 79/273 (28%), Positives = 109/273 (39%), Gaps = 59/273 (21%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACK----KRTEY-------------------- 237
            C  G C N +  +RC+CL    +   G+ C     + T Y                    
Sbjct: 582  CVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSE 641

Query: 238  -----------KPNQMNDAASSFNLKSQCDK---------------FGSFLCKNGRCIES 339
                       +P Q+  A +S   ++ C                     +C NG C   
Sbjct: 642  CCCANPDHGFGEPCQLCPAKNSAEFQALCSSGLGITTDGRDINECALDPEVCANGVCENL 701

Query: 340  GSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMP 519
              SY C CNLG++  + GK C+D+DEC  N  +CD G C NSPGSY CSC  GF  H   
Sbjct: 702  RGSYRCVCNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGF--HFWQ 759

Query: 520  GGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSG--------YVASSNKQDC-ISIQ 672
                C D +EC    S C +GVC N+ GS+ C+C  G        +   S K  C + IQ
Sbjct: 760  DTEICKDVDECL--SSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQ 817

Query: 673  DSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSC 771
            +    S  + N +  S  S  CA +   +   C
Sbjct: 818  E----SRCEVNLQGASLRSECCATLGAAWGSPC 846

 Score =  112 bits (280), Expect = 1e-24
 Identities = 66/214 (30%), Positives = 93/214 (43%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNG 324
            C+N+   + C CLP +V D  G  C           +D     + + +C          G
Sbjct: 1297 CLNIPGSFSCRCLPGWVGD--GFEC-----------HDLDECVSQEHRCSP-------RG 1336

Query: 325  RCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFT 504
             C+    SY C C  GF  + DG  C D DEC  N  +CD G C+N+PG Y+C C  GF 
Sbjct: 1337 DCLNVPGSYRCTCRQGF--AGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGF- 1393

Query: 505  IHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSD 684
                     C D +EC++  +LC  G C N+ G F+C CN GY       +C  I + +D
Sbjct: 1394 -DPTEDHRACQDVDECAQG-NLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECAD 1451

Query: 685  YSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
                       +  +  C    G++ CSCP   E
Sbjct: 1452 ---------PVNCINGVCINTPGSYLCSCPQDFE 1476

 Score =  111 bits (278), Expect = 2e-24
 Identities = 77/292 (26%), Positives = 114/292 (39%), Gaps = 62/292 (21%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPN-QMNDAASSFNLKS------------ 285
            CIN +  YRC C   + L   G+AC    E + N ++ D     N+              
Sbjct: 1170 CINTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCDQGHCTNMPGGHRCLCYDGFMA 1229

Query: 286  -----------QCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNP 432
                       +CD     +C +G C  +  S+ C C LG+        CSD+DEC    
Sbjct: 1230 TPDMRTCVDVDECD-LNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGG 1288

Query: 433  TICD-RGTCINSPGSYQCSCY-----DGFTIH-------------------NMPG----- 522
              CD   +C+N PGS+ C C      DGF  H                   N+PG     
Sbjct: 1289 HNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCT 1348

Query: 523  --------GPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDS 678
                    G  C DR+EC+E+  LC NG C+N  G ++C+C  G+  + + + C  + + 
Sbjct: 1349 CRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDEC 1408

Query: 679  SDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVD 834
            +           C+  S  C  + G F+C C  G E     G C   ++  D
Sbjct: 1409 A-------QGNLCAFGS--CENLPGMFRCICNGGYELDRGGGNCTDINECAD 1451

 Score =  110 bits (274), Expect = 7e-24
 Identities = 72/239 (30%), Positives = 97/239 (40%), Gaps = 27/239 (11%)
 Frame = +1

Query: 145  CINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK-- 318
            C N K  + C C   ++L++ G+ CK   E    Q N      N        G+F C+  
Sbjct: 2420 CKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNT------VGAFTCRCP 2473

Query: 319  -------------------------NGRCIESGSSYECKCNLGFQESSDGKICSDIDECT 423
                                     +G C  +  S+ C+C+ GF   S G  C D++EC 
Sbjct: 2474 PGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD 2533

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
              P  C  G C N  G Y+CSC  GFT H+     +C D NEC+     C +  C N  G
Sbjct: 2534 -GPHRCQHG-CQNQLGGYRCSCPQGFTQHSQ--WAQCVDENECALSPPTCGSASCRNTLG 2589

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYG 780
             F+C C SG+        C   QD      VD+ +     CS+ CA   G F C CP G
Sbjct: 2590 GFRCVCPSGFDFDQALGGC---QD------VDECAGRRGPCSYSCANTPGGFLCGCPQG 2639

 Score =  108 bits (271), Expect = 2e-23
 Identities = 70/236 (29%), Positives = 101/236 (42%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G CIN    +RCEC   F  +    AC+           D     + +S C +    
Sbjct: 1732 CANGICINQIGSFRCECPAGFNYNSILLACE-----------DVDECGSRESPCQQ---- 1776

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
               N  CI    SY CKC  G++ S  G  C   +EC   P +C  G C+++ GSY C C
Sbjct: 1777 ---NADCINIPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDCMDTEGSYMCLC 1832

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
            + GF          C D +EC  D+  C NG C NI GS+ C C  G+V + N  DC+  
Sbjct: 1833 HRGFQAS--ADQTLCMDIDEC--DRQPCGNGTCKNIIGSYNCLCFPGFVVTHNG-DCVDF 1887

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
             + +  + V    ++      +C    G+F C C  G E   D   C   ++ + +
Sbjct: 1888 DECT--TLVGQVCRF-----GHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSL 1936

 Score =  106 bits (264), Expect = 1e-22
 Identities = 75/282 (26%), Positives = 113/282 (40%), Gaps = 55/282 (19%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQM--------NDAASSFNLK- 282
            C  GRC+N +  ++C C   F L   G+ C    E   + M         D + S   K 
Sbjct: 500  CHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKP 559

Query: 283  --------------SQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDEC 420
                           +C   G  +C NG C  +  S+ C+C  G    +DG++C D    
Sbjct: 560  GFLLAPGGHYCMDIDECQTPG--ICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVR 617

Query: 421  TTNPTICDRGTCINS-PGSY---QCSCYD---GFTIHNMPGGPKCY-------------- 537
            +T     ++G+C    PG+    +C C +   GF       G  C               
Sbjct: 618  STCYGAIEKGSCARPFPGTVTKSECCCANPDHGF-------GEPCQLCPAKNSAEFQALC 670

Query: 538  -----------DRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSD 684
                       D NEC+ D  +C NGVC N+ GS++C CN GY A ++ +DC  + + + 
Sbjct: 671  SSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECAL 730

Query: 685  YSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLC 810
             S + DN         +C    G++ CSCP G     DT +C
Sbjct: 731  NSLLCDNG--------WCQNSPGSYSCSCPPGFHFWQDTEIC 764

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 54/165 (32%), Positives = 77/165 (46%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +C NG C+ +  S+ C+C  G+     G  C D DEC+     C +GTC N  G ++C+C
Sbjct: 2094 VCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP-CGQGTCTNVIGGFECAC 2152

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISI 669
             DGF    M     C D +ECS +  LC    C N  GS+ C C +GY    +   C  +
Sbjct: 2153 ADGFEPGLMM---TCEDIDECSLNPLLCAFR-CHNTEGSYLCTCPAGYTLREDGAMCRDV 2208

Query: 670  QDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTG 804
             + +D        + C      C  + GTF C CP GM  +  +G
Sbjct: 2209 DECAD------GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSG 2247

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 71/248 (28%), Positives = 98/248 (39%), Gaps = 15/248 (6%)
 Frame = +1

Query: 112  SYYSEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTE------YKPNQMNDAASSF 273
            S +S  C  G C N    Y C C  +++    G  C    +      Y     N+ A + 
Sbjct: 1610 STHSSICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNV 1669

Query: 274  NLKSQCDKFGSFLCKNGRC----IESGSSYECKCNL---GFQESSDGKICSDIDECTTNP 432
              K  C  +      N  C          Y+  C     GF          DIDEC   P
Sbjct: 1670 TRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIP 1729

Query: 433  TICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCK-NGVCINIHGSF 609
             IC  G CIN  GS++C C  GF  +++     C D +EC   +S C+ N  CINI GS+
Sbjct: 1730 AICANGICINQIGSFRCECPAGFNYNSILLA--CEDVDECGSRESPCQQNADCINIPGSY 1787

Query: 610  KCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVNGTFKCSCPYGME 786
            +C+C  GY  S     C+   +  +   V         CSH  C    G++ C C  G +
Sbjct: 1788 RCKCTRGYKLSPGGA-CVGRNECREIPNV---------CSHGDCMDTEGSYMCLCHRGFQ 1837

Query: 787  SILDTGLC 810
            +  D  LC
Sbjct: 1838 ASADQTLC 1845

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 64/232 (27%), Positives = 83/232 (35%), Gaps = 43/232 (18%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C+N    +RCEC   + LD  G  C    E                         
Sbjct: 2095 CTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHP------------------- 2135

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
             C  G C      +EC C  GF E      C DIDEC+ NP +C    C N+ GSY C+C
Sbjct: 2136 -CGQGTCTNVIGGFECACADGF-EPGLMMTCEDIDECSLNPLLC-AFRCHNTEGSYLCTC 2192

Query: 490  YDGFTIHN------------------------------------------MPG-GPKCYD 540
              G+T+                                            +PG G  C D
Sbjct: 2193 PAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTD 2252

Query: 541  RNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAV 696
             NEC     LC NG C+N  GSF+C C+ G+  S    +C  I+    ++ V
Sbjct: 2253 DNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEV 2304

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 58/205 (28%), Positives = 77/205 (37%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C N    +RCEC   F L   G  C+   E                  CD  G   C+
Sbjct: 2500 GHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE------------------CD--GPHRCQ 2539

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C      Y C C  GF + S    C D +EC  +P  C   +C N+ G ++C C  G
Sbjct: 2540 HG-CQNQLGGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSG 2598

Query: 499  FTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDS 678
            F      GG  C D +EC+  +  C    C N  G F C C  GY  +        +  S
Sbjct: 2599 FDFDQALGG--CQDVDECAGRRGPCSYS-CANTPGGFLCGCPQGYFRAGQGHCVSGLGFS 2655

Query: 679  SDYSAVDDNSKYCSKCSHYCAFVNG 753
                   D  +  S  + Y   +NG
Sbjct: 2656 PGPQDTPDKEELLSSEACYECKING 2680

 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 67/251 (26%), Positives = 93/251 (37%), Gaps = 22/251 (8%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFG 303
            E C  G C N++  YRC C   +     G+ C    E   N                   
Sbjct: 691  EVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDECALN------------------- 731

Query: 304  SFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQC 483
            S LC NG C  S  SY C C  GF    D +IC D+DEC ++P  C  G C N  GSY C
Sbjct: 732  SLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSP--CVSGVCRNLAGSYTC 789

Query: 484  SCYDGFTIHNMPGGPKCYD-------------RNECSEDKSLCKNGVCINIHGSF----- 609
             C  G  +   P G  C D             R E +   +  ++  C  +  ++     
Sbjct: 790  KCGPGSRLD--PSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAAWGSPCE 847

Query: 610  KCQ----CNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPY 777
            +C+    C  G+ A      C  + +   +  V  N +        C    G+F+C CP 
Sbjct: 848  RCEIDPACARGF-ARMTGVTCDDVNECESFPGVCPNGR--------CVNTAGSFRCECPE 898

Query: 778  GMESILDTGLC 810
            G+       LC
Sbjct: 899  GLMLDASGRLC 909

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 67/264 (25%), Positives = 89/264 (33%), Gaps = 51/264 (19%)
 Frame = +1

Query: 142  RCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF---- 309
            RC N +  Y C C   + L + G  C+   E    Q +  A     K+    F       
Sbjct: 2180 RCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPG 2239

Query: 310  ----------------------LCKNGRCIESGSSYECKCNLGFQESSDGKICSDI---- 411
                                  LC NGRC+ +  S+ C C+ GFQ S     C DI    
Sbjct: 2240 MRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGP 2299

Query: 412  ----------------DECTTNPTICDRGTCINSPGSYQC-----SCYDGFTIHNMPGGP 528
                             E  T    C  G     P    C     S Y     H      
Sbjct: 2300 CFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTA 2359

Query: 529  KCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNS 708
            +  D +EC     LC +G CIN  GSF+C C +GY   +    C+          +D+ S
Sbjct: 2360 EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLD---------MDECS 2410

Query: 709  KYCSKCSHYCAFVNGTFKCSCPYG 780
            +    C+  C    G+F CSCP G
Sbjct: 2411 QVPKPCTFLCKNTKGSFLCSCPRG 2434

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 76/275 (27%), Positives = 114/275 (41%), Gaps = 39/275 (14%)
 Frame = +1

Query: 172  CECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCKNGRCIESGSSY 351
            CE  P     +    C     ++PN++       +   +C +    LC+ G C+ +  S+
Sbjct: 1531 CELCPMANTTEYRTLCPGGEGFQPNRITVILEDID---ECQELPG-LCQGGDCVNTFGSF 1586

Query: 352  ECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPK 531
            +C+C  G+  S   +IC DIDEC+T+ +IC  GTC N+ G+Y C C   +   N  GG  
Sbjct: 1587 QCECPPGYHLSEHTRICEDIDECSTHSSICGPGTCYNTLGNYTCVCPAEYLQVN--GGNN 1644

Query: 532  CYDRNECSEDKSLC---KNGVCIN---IHGSFKCQCNSGYVASSNKQDCISIQD--SSDY 687
            C D       KS+C    NG C N    + + K  C S  +  +  + C +     S DY
Sbjct: 1645 CMDMR-----KSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDY 1699

Query: 688  SAVDDNS----------------KYCSKCSHYCA---FVN--GTFKCSCPYGM--ESIL- 795
              +  N                   C +    CA    +N  G+F+C CP G    SIL 
Sbjct: 1700 QILCGNQAPGFLTDIHTGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILL 1759

Query: 796  ---DTGLC----APNSQIVDVQFDIPNNIRARVKR 879
               D   C    +P  Q  D   +IP + R +  R
Sbjct: 1760 ACEDVDECGSRESPCQQNADC-INIPGSYRCKCTR 1793

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 63/256 (24%), Positives = 97/256 (37%), Gaps = 29/256 (11%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C+N    YRCEC   F   +  +AC+   E                         
Sbjct: 1373 CDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN-------------------- 1412

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            LC  G C      + C CN G++    G  C+DI+EC  +P  C  G CIN+PGSY CSC
Sbjct: 1413 LCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINECA-DPVNCINGVCINTPGSYLCSC 1471

Query: 490  YDGFTIHNMPGGPKCYD---------RNECSEDKSLCKNGVCINIHGSFKCQCNSGYVAS 642
               F ++  P G  C D          ++  +    C   + + +  +  C C+ G  A 
Sbjct: 1472 PQDFELN--PSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRA-SCCCSLGR-AW 1527

Query: 643  SNKQDCISIQDSSDYSA-------------------VDDNSKYCSKC-SHYCAFVNGTFK 762
             N  +   + ++++Y                     +D+  +    C    C    G+F+
Sbjct: 1528 GNPCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQ 1587

Query: 763  CSCPYGMESILDTGLC 810
            C CP G      T +C
Sbjct: 1588 CECPPGYHLSEHTRIC 1603

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 66/251 (26%), Positives = 89/251 (35%), Gaps = 32/251 (12%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G C N++  +RC C P F +             +PN                     
Sbjct: 1940 CLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPN--------------------- 1978

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDE--CTTN------------PTICDR 447
            LC  G C  S  S++C C  GF  S +G  C D  +  C T              T   R
Sbjct: 1979 LCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTR 2038

Query: 448  GTCINSPG----------------SYQCSCYDGFTIHNMPGGP--KCYDRNECSEDKSLC 573
              C   PG                ++Q  C  G   H    GP     D NEC+E+  +C
Sbjct: 2039 CCCSKRPGEGWGDPCELCPQEGSAAFQELCPFG---HGAVPGPDDSREDVNECAENPGVC 2095

Query: 574  KNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNG 753
             NGVC+N  GSF+C+C  GY       +C+   + S        +         C  V G
Sbjct: 2096 TNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGT---------CTNVIG 2146

Query: 754  TFKCSCPYGME 786
             F+C+C  G E
Sbjct: 2147 GFECACADGFE 2157

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 71/300 (23%), Positives = 112/300 (37%), Gaps = 68/300 (22%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQ----------MNDAASSFNL 279
            C+GG C+NM   + C C     L     AC+   +Y+               D A  +  
Sbjct: 258  CQGGSCVNMVGSFHCRCPVGHRLSDSSAACE---DYRAGACFSVLFGGRCAGDLAGHYTR 314

Query: 280  KSQCDKFGSFLCKNGRCIESG-----------SSYECKCN----------------LGFQ 378
            +  C       C  GRC  +G           + ++  C                 LGF 
Sbjct: 315  RQCC-------CDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFG 367

Query: 379  ES----------------------SDGKICSDIDECTTNPTI---------CDRGTCINS 465
             +                      S G   S+I   T N TI         C  G C+ +
Sbjct: 368  SNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPT 427

Query: 466  PGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVASS 645
            P SY+C C  G+T  ++ G  +C D +EC+   S C +G C+NI G++ C+C  G+ A+ 
Sbjct: 428  PSSYRCECNVGYT-QDVRG--ECIDVDECT--SSPCHHGDCVNIPGTYHCRCYPGFQATP 482

Query: 646  NKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAPNSQ 825
             +Q C+ +    D   V     +  +C +      G+F+C C  G E   D   C  +++
Sbjct: 483  TRQACVDV----DECIVSGGLCHLGRCVN----TEGSFQCVCNAGFELSPDGKNCVDHNE 534

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 65/275 (23%), Positives = 106/275 (38%), Gaps = 39/275 (14%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+GG C+N    ++CEC P + L +  + C+   E   +                   S 
Sbjct: 1574 CQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTH-------------------SS 1614

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDR---GTCIN------ 462
            +C  G C  +  +Y C C   + + + G  C D+       ++C R   GTC N      
Sbjct: 1615 ICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDM-----RKSVCFRHYNGTCQNELAFNV 1669

Query: 463  --------------------------SPGSYQCSCYD---GFTIHNMPGGPKCYDRNECS 555
                                      SP  YQ  C +   GF      G P   D +EC 
Sbjct: 1670 TRKMCCCSYNIGQAWNRPCEACPTPISP-DYQILCGNQAPGFLTDIHTGKP--LDIDECG 1726

Query: 556  EDKSLCKNGVCINIHGSFKCQCNSGYVASSNKQDCISIQD-SSDYSAVDDNSKYCSKCSH 732
            E  ++C NG+CIN  GSF+C+C +G+  +S    C  + +  S  S    N+        
Sbjct: 1727 EIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNAD------- 1779

Query: 733  YCAFVNGTFKCSCPYGMESILDTGLCAPNSQIVDV 837
             C  + G+++C C  G + +   G C   ++  ++
Sbjct: 1780 -CINIPGSYRCKCTRGYK-LSPGGACVGRNECREI 1812

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 60/266 (22%), Positives = 96/266 (36%), Gaps = 46/266 (17%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRT------EYKPNQMNDAASSFNLK 282
            S  C  G C N+   Y C+C P   LD  G  C   T      + + ++        +L+
Sbjct: 772  SSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLR 831

Query: 283  SQCDKFGSFLCKNGRCIESGSSYECK----CNLGFQESSDGKICSDIDECTTNPTICDRG 450
            S+C       C             C+    C  GF   + G  C D++EC + P +C  G
Sbjct: 832  SEC-------CATLGAAWGSPCERCEIDPACARGFARMT-GVTCDDVNECESFPGVCPNG 883

Query: 451  TCINSPGSYQCSCYDGFTIHNMPGGPKC-----------YDRNECSEDKSLCKNGVCINI 597
             C+N+ GS++C C +G  +     G  C           +D +EC            + +
Sbjct: 884  RCVNTAGSFRCECPEGLMLD--ASGRLCVDVRLEPCFLRWDEDECG-----------VTL 930

Query: 598  HGSFK---CQCNSGYVASSNKQDCISIQD--------------SSD-------YSAVDDN 705
             G ++   C C+ G V     + C   +               S D       Y  V++ 
Sbjct: 931  PGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNEC 990

Query: 706  SKYCSKCSH-YCAFVNGTFKCSCPYG 780
              +   C+H  C    G+F C+C  G
Sbjct: 991  KVFPGLCTHGTCRNTVGSFHCACAGG 1016

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 46/173 (26%), Positives = 65/173 (37%), Gaps = 13/173 (7%)
 Frame = +1

Query: 136 GGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKP--NQMNDAASSFNLKSQ-CDKFGS 306
           GGRCI      RC C+  F+    G  C++     P   Q+        L    C K   
Sbjct: 158 GGRCIGPN---RCACVYGFM----GPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKA-- 208

Query: 307 FLCKNGRCIESGSSYECKCNL----------GFQESSDGKICSDIDECTTNPTICDRGTC 456
            LC    C   G ++   C L          GF  +     C D+DEC   P +C  G+C
Sbjct: 209 -LC----CATVGRAWGLPCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSC 263

Query: 457 INSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKC 615
           +N  GS+ C C         P G +  D +   ED    + G C ++    +C
Sbjct: 264 VNMVGSFHCRC---------PVGHRLSDSSAACED---YRAGACFSVLFGGRC 304
>sp|Q8CG18|LTB1S_MOUSE Latent transforming growth factor beta binding protein, isoform 1S
            precursor (LTBP-1) (Transforming growth factor beta-1
            binding protein 1) (TGF-beta1-BP-1)
          Length = 1389

 Score =  131 bits (329), Expect = 3e-30
 Identities = 72/248 (29%), Positives = 112/248 (45%), Gaps = 21/248 (8%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCEC------LPDFVLDKQGQACKKRTEYKPNQMNDAASSFNL---- 279
            C  G C N++  Y C C       PD    +    C++       Q  +   SF      
Sbjct: 717  CTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRNTDGSFRCTCGQ 776

Query: 280  -------KSQCDKFGS----FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT 426
                   K QC+         LC +G+C  +  S++C CN G++ S  G  C DI+EC  
Sbjct: 777  GYQLSAAKDQCEDIDECEHHHLCSHGQCRNTEGSFQCVCNQGYRASVLGDHCEDINECLE 836

Query: 427  NPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGS 606
            + ++C  G CIN+ GSY C+C DGF +++  G   C D NEC++      +G C+N  GS
Sbjct: 837  DSSVCQGGDCINTAGSYDCTCPDGFQLNDNKG---CQDINECAQPGLCGSHGECLNTQGS 893

Query: 607  FKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
            F C C  G+  S++ + C  I +  + +  D +         +C    G+F+C C  G +
Sbjct: 894  FHCVCEQGFSISADGRTCEDIDECVNNTVCDSHG--------FCDNTAGSFRCLCYQGFQ 945

Query: 787  SILDTGLC 810
            +  D   C
Sbjct: 946  APQDGQGC 953

 Score =  119 bits (298), Expect = 1e-26
 Identities = 75/270 (27%), Positives = 114/270 (42%), Gaps = 31/270 (11%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCE-CLPDFVLDKQGQA-----CKKRTEYKPNQMNDAASSFNLKS 285
            + C+ GRCIN    +RCE C   + + ++G       C K +     Q  +   S+    
Sbjct: 634  DMCRDGRCINTAGAFRCEYCDSGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVP 693

Query: 286  QCDKFGSF--------------LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECT 423
              + F  +              +C NG C     SY C C+ G+  + D + C DIDEC 
Sbjct: 694  CTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQ 753

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
                +C  G C N+ GS++C+C  G+ +       +C D +EC E   LC +G C N  G
Sbjct: 754  QG-NLCMNGQCRNTDGSFRCTCGQGYQL--SAAKDQCEDIDEC-EHHHLCSHGQCRNTEG 809

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGM 783
            SF+C CN GY AS     C  I +  + S+V             C    G++ C+CP G 
Sbjct: 810  SFQCVCNQGYRASVLGDHCEDINECLEDSSVCQGGD--------CINTAGSYDCTCPDGF 861

Query: 784  E-----------SILDTGLCAPNSQIVDVQ 840
            +                GLC  + + ++ Q
Sbjct: 862  QLNDNKGCQDINECAQPGLCGSHGECLNTQ 891

 Score =  115 bits (288), Expect = 2e-25
 Identities = 75/240 (31%), Positives = 108/240 (45%), Gaps = 23/240 (9%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTE-YKPNQMND-----AASSF------ 273
            C  GRC N +  + C C   F+  ++G  C    E  +P+   D      A +F      
Sbjct: 595  CSQGRCENTEGSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFRCEYCD 654

Query: 274  -----NLKSQCDKFGSFL----CKNGRCIESGSSYEC-KCNLGFQESSDGKICSDIDECT 423
                 + +  C+     L    C   +C+ +  SY+C  C  GF+   +G+ C D+DEC 
Sbjct: 655  SGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVPCTEGFR-GWNGQ-CLDVDEC- 711

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
              P +C  G+C N  GSY CSC+ G++    P    C D +EC +  +LC NG C N  G
Sbjct: 712  LQPKVCTNGSCTNLEGSYMCSCHRGYS--PTPDHRHCQDIDECQQG-NLCMNGQCRNTDG 768

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVNGTFKCSCPYG 780
            SF+C C  GY  S+ K  C  I          D  ++   CSH  C    G+F+C C  G
Sbjct: 769  SFRCTCGQGYQLSAAKDQCEDI----------DECEHHHLCSHGQCRNTEGSFQCVCNQG 818

 Score =  111 bits (278), Expect = 2e-24
 Identities = 75/252 (29%), Positives = 116/252 (46%), Gaps = 33/252 (13%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQ--CDKF- 300
            C  G CIN+  +Y C C   +   +Q + C          +++ A   +L SQ  C+   
Sbjct: 553  CGAGHCINLPVRYTCICYEGYKFSEQLRKCV--------DIDECAQVRHLCSQGRCENTE 604

Query: 301  GSFL---------------------------CKNGRCIESGSSYECK-CNLGFQESSDGK 396
            GSFL                           C++GRCI +  ++ C+ C+ G++ S  G 
Sbjct: 605  GSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFRCEYCDSGYRMSRRG- 663

Query: 397  ICSDIDECTTNPTICDRGTCINSPGSYQC-SCYDGFTIHNMPGGPKCYDRNECSEDKSLC 573
             C DIDEC   P+ C    C+N+PGSYQC  C +GF   N     +C D +EC + K +C
Sbjct: 664  YCEDIDEC-LKPSTCPEEQCVNTPGSYQCVPCTEGFRGWN----GQCLDVDECLQPK-VC 717

Query: 574  KNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVN 750
             NG C N+ GS+ C C+ GY  + + + C  I          D  +  + C +  C   +
Sbjct: 718  TNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDI----------DECQQGNLCMNGQCRNTD 767

Query: 751  GTFKCSCPYGME 786
            G+F+C+C  G +
Sbjct: 768  GSFRCTCGQGYQ 779

 Score =  109 bits (272), Expect = 1e-23
 Identities = 62/169 (36%), Positives = 81/169 (47%), Gaps = 2/169 (1%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF 300
            S  C+GG CIN    Y C C   F                  Q+ND     ++ ++C + 
Sbjct: 838  SSVCQGGDCINTAGSYDCTCPDGF------------------QLNDNKGCQDI-NECAQP 878

Query: 301  GSFLC-KNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICD-RGTCINSPGS 474
            G  LC  +G C+ +  S+ C C  GF  S+DG+ C DIDEC  N T+CD  G C N+ GS
Sbjct: 879  G--LCGSHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNN-TVCDSHGFCDNTAGS 935

Query: 475  YQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
            ++C CY GF       G  C D NEC     +C    C N+ GSF C C
Sbjct: 936  FRCLCYQGFQAPQ--DGQGCVDVNECELLSGVCGEAFCENVEGSFLCVC 982

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 38/91 (41%), Positives = 53/91 (58%)
 Frame = +1

Query: 403 SDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNG 582
           ++I+ECT NP IC  G CIN P  Y C CY+G+         KC D +EC++ + LC  G
Sbjct: 541 TEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQL--RKCVDIDECAQVRHLCSQG 598

Query: 583 VCINIHGSFKCQCNSGYVASSNKQDCISIQD 675
            C N  GSF C C +G++AS    +CI + +
Sbjct: 599 RCENTEGSFLCVCPAGFMASEEGTNCIDVDE 629

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 56/198 (28%), Positives = 81/198 (40%), Gaps = 31/198 (15%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +C  G CI     Y C C  G++ S   + C DIDEC     +C +G C N+ GS+ C C
Sbjct: 552  ICGAGHCINLPVRYTCICYEGYKFSEQLRKCVDIDECAQVRHLCSQGRCENTEGSFLCVC 611

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQ-CNSGYVAS-----SNK 651
              GF       G  C D +EC     +C++G CIN  G+F+C+ C+SGY  S      + 
Sbjct: 612  PAGFMASE--EGTNCIDVDECLR-PDMCRDGRCINTAGAFRCEYCDSGYRMSRRGYCEDI 668

Query: 652  QDCISIQDSSDYSAVDDNSKY-CSKCSH------------------------YCAFVNGT 756
             +C+      +   V+    Y C  C+                          C  + G+
Sbjct: 669  DECLKPSTCPEEQCVNTPGSYQCVPCTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGS 728

Query: 757  FKCSCPYGMESILDTGLC 810
            + CSC  G     D   C
Sbjct: 729  YMCSCHRGYSPTPDHRHC 746

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 34/91 (37%), Positives = 43/91 (47%), Gaps = 3/91 (3%)
 Frame = +1

Query: 439  CDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSE---DKSLCKNGVCINIHGSF 609
            C+ G C+     Y C C+DG+  H       C D NECSE     SLCKN  CIN  GS+
Sbjct: 1299 CENGRCVRVHEGYTCDCFDGY--HLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSY 1356

Query: 610  KCQCNSGYVASSNKQDCISIQDSSDYSAVDD 702
            KC C  GY+ S     C  +  + +     D
Sbjct: 1357 KCLCLPGYIPSDKPNYCTPLNSALNLDKESD 1387

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 48/182 (26%), Positives = 70/182 (38%), Gaps = 18/182 (9%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C+N +  + C C   F +   G+ C+   E   N + D+                   
Sbjct: 885  GECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDS------------------- 925

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C  +  S+ C C  GFQ   DG+ C D++EC     +C    C N  GS+ C C D 
Sbjct: 926  HGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADE 985

Query: 499  FTIHNMPGGPKCYDR---------------NEC---SEDKSLCKNGVCINIHGSFKCQCN 624
               ++ P   +C  R                EC     D SLC N +  N+    +C C 
Sbjct: 986  NQEYS-PMTGQCRSRVTEDSGVDRQpreEKKECYYNLNDASLCDNVLAPNVTKQ-ECCCT 1043

Query: 625  SG 630
            SG
Sbjct: 1044 SG 1045

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 58/234 (24%), Positives = 96/234 (41%), Gaps = 27/234 (11%)
 Frame = +1

Query: 154  MKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDK-FGSFLCKNGRC 330
            M  Q R     D  +D+Q +  KK   Y    +NDA       S CD      + K   C
Sbjct: 992  MTGQCRSRVTEDSGVDRQpreEKKECYYN---LNDA-------SLCDNVLAPNVTKQECC 1041

Query: 331  IESGSSYECKCNL------GFQESSD-------------------GKICSDIDECTT-NP 432
              SG+ +   C +      G  E ++                   G+   D DEC     
Sbjct: 1042 CTSGAGWGDNCEIFPCPVQGTAEFTEMCPRGKGLVPAGESSYDTGGENYKDADECLLFGE 1101

Query: 433  TICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFK 612
             IC  G C+N+   Y+C C  G   +  P   +C+D +EC +D + C +G C+N  GS+ 
Sbjct: 1102 EICKNGYCLNTQPGYECYCKQG--TYYDPVKLQCFDMDEC-QDPNSCIDGQCVNTEGSYN 1158

Query: 613  CQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCP 774
            C C    V  ++++ C+   +S++   +++   Y   C  +   ++  + CS P
Sbjct: 1159 CFCTHPMVLDASEKRCVQPTESNE--QIEETDVYQDLCWEH---LSEEYVCSRP 1207

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
 Frame = +1

Query: 313  CKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECT---TNPTICDRGTCINSPGSYQC 483
            C+NGRC+     Y C C  G+        C D++EC+      ++C    CIN+ GSY+C
Sbjct: 1299 CENGRCVRVHEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSYKC 1358

Query: 484  SCYDGFTIHNMP 519
             C  G+   + P
Sbjct: 1359 LCLPGYIPSDKP 1370

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 49/239 (20%), Positives = 79/239 (33%), Gaps = 10/239 (4%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C+N +  Y C C    VLD   + C + TE   N+  +    +           +
Sbjct: 1145 CIDGQCVNTEGSYNCFCTHPMVLDASEKRCVQPTE--SNEQIEETDVYQDLCWEHLSEEY 1202

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKIC--SDIDE--------CTTNPTICDRGTCI 459
            +C      +  +  EC C  G        +C   D D+         T       R   +
Sbjct: 1203 VCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALV 1262

Query: 460  NSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVA 639
            +    Y       F         +     EC      C+NG C+ +H  + C C  GY  
Sbjct: 1263 DFSEQYGPETDPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRVHEGYTCDCFDGYHL 1321

Query: 640  SSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAP 816
               K  C+ + + S+   +++    C      C    G++KC C  G         C P
Sbjct: 1322 DMAKMTCVDVNECSE---LNNRMSLCKNAK--CINTEGSYKCLCLPGYIPSDKPNYCTP 1375

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 26/95 (27%), Positives = 42/95 (44%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ GRC+ +   Y C+C   + LD     C    E   +++N+  S              
Sbjct: 1299 CENGRCVRVHEGYTCDCFDGYHLDMAKMTCVDVNEC--SELNNRMS-------------- 1342

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDID 414
            LCKN +CI +  SY+C C  G+  S     C+ ++
Sbjct: 1343 LCKNAKCINTEGSYKCLCLPGYIPSDKPNYCTPLN 1377

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 50/174 (28%), Positives = 66/174 (37%), Gaps = 3/174 (1%)
 Frame = +1

Query: 271 FNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRG 450
           FN   +C K  S+          G +   +C  G++  ++   C DI+EC     +C  G
Sbjct: 260 FNKCQKCPKKQSY---------HGYTQMMECLQGYKRVNN-TFCQDINECQLQG-VCPNG 308

Query: 451 TCINSPGSYQCSCYDGFTIHNMPGGPKCY-DRNECSEDKSLCKNGVCINIHGSFKCQCNS 627
            C+N+ GSY+CSC  GF     P    C  D    SE+K  C   V    H      C  
Sbjct: 309 ECLNTMGSYRCSCKMGFGPD--PTFSSCVPDPPVISEEKGPCYRLVSPGRH------CMH 360

Query: 628 GYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGT--FKCSCPYGM 783
                  KQ C         S       +C KC      + GT  FK  CP GM
Sbjct: 361 PLSVHLTKQICCC-------SVGKAWGPHCEKCP-----LPGTAAFKEICPGGM 402

 Score = 36.2 bits (82), Expect = 0.12
 Identities = 25/80 (31%), Positives = 36/80 (45%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFG 303
            E CK G C+N +  Y C C       KQG      T Y P ++      F++  +C    
Sbjct: 1102 EICKNGYCLNTQPGYECYC-------KQG------TYYDPVKL----QCFDM-DECQDPN 1143

Query: 304  SFLCKNGRCIESGSSYECKC 363
            S  C +G+C+ +  SY C C
Sbjct: 1144 S--CIDGQCVNTEGSYNCFC 1161
>sp|Q8CG19|LTB1L_MOUSE Latent transforming growth factor beta binding protein, isoform 1L
            precursor (LTBP-1) (Transforming growth factor beta-1
            binding protein 1) (TGF-beta1-BP-1)
          Length = 1713

 Score =  131 bits (329), Expect = 3e-30
 Identities = 72/248 (29%), Positives = 112/248 (45%), Gaps = 21/248 (8%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCEC------LPDFVLDKQGQACKKRTEYKPNQMNDAASSFNL---- 279
            C  G C N++  Y C C       PD    +    C++       Q  +   SF      
Sbjct: 1041 CTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQQGNLCMNGQCRNTDGSFRCTCGQ 1100

Query: 280  -------KSQCDKFGS----FLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTT 426
                   K QC+         LC +G+C  +  S++C CN G++ S  G  C DI+EC  
Sbjct: 1101 GYQLSAAKDQCEDIDECEHHHLCSHGQCRNTEGSFQCVCNQGYRASVLGDHCEDINECLE 1160

Query: 427  NPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGS 606
            + ++C  G CIN+ GSY C+C DGF +++  G   C D NEC++      +G C+N  GS
Sbjct: 1161 DSSVCQGGDCINTAGSYDCTCPDGFQLNDNKG---CQDINECAQPGLCGSHGECLNTQGS 1217

Query: 607  FKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGME 786
            F C C  G+  S++ + C  I +  + +  D +         +C    G+F+C C  G +
Sbjct: 1218 FHCVCEQGFSISADGRTCEDIDECVNNTVCDSHG--------FCDNTAGSFRCLCYQGFQ 1269

Query: 787  SILDTGLC 810
            +  D   C
Sbjct: 1270 APQDGQGC 1277

 Score =  119 bits (298), Expect = 1e-26
 Identities = 75/270 (27%), Positives = 114/270 (42%), Gaps = 31/270 (11%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCE-CLPDFVLDKQGQA-----CKKRTEYKPNQMNDAASSFNLKS 285
            + C+ GRCIN    +RCE C   + + ++G       C K +     Q  +   S+    
Sbjct: 958  DMCRDGRCINTAGAFRCEYCDSGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVP 1017

Query: 286  QCDKFGSF--------------LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECT 423
              + F  +              +C NG C     SY C C+ G+  + D + C DIDEC 
Sbjct: 1018 CTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDIDECQ 1077

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
                +C  G C N+ GS++C+C  G+ +       +C D +EC E   LC +G C N  G
Sbjct: 1078 QG-NLCMNGQCRNTDGSFRCTCGQGYQL--SAAKDQCEDIDEC-EHHHLCSHGQCRNTEG 1133

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGM 783
            SF+C CN GY AS     C  I +  + S+V             C    G++ C+CP G 
Sbjct: 1134 SFQCVCNQGYRASVLGDHCEDINECLEDSSVCQGGD--------CINTAGSYDCTCPDGF 1185

Query: 784  E-----------SILDTGLCAPNSQIVDVQ 840
            +                GLC  + + ++ Q
Sbjct: 1186 QLNDNKGCQDINECAQPGLCGSHGECLNTQ 1215

 Score =  115 bits (288), Expect = 2e-25
 Identities = 75/240 (31%), Positives = 108/240 (45%), Gaps = 23/240 (9%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTE-YKPNQMND-----AASSF------ 273
            C  GRC N +  + C C   F+  ++G  C    E  +P+   D      A +F      
Sbjct: 919  CSQGRCENTEGSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFRCEYCD 978

Query: 274  -----NLKSQCDKFGSFL----CKNGRCIESGSSYEC-KCNLGFQESSDGKICSDIDECT 423
                 + +  C+     L    C   +C+ +  SY+C  C  GF+   +G+ C D+DEC 
Sbjct: 979  SGYRMSRRGYCEDIDECLKPSTCPEEQCVNTPGSYQCVPCTEGFR-GWNGQ-CLDVDEC- 1035

Query: 424  TNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHG 603
              P +C  G+C N  GSY CSC+ G++    P    C D +EC +  +LC NG C N  G
Sbjct: 1036 LQPKVCTNGSCTNLEGSYMCSCHRGYS--PTPDHRHCQDIDECQQG-NLCMNGQCRNTDG 1092

Query: 604  SFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVNGTFKCSCPYG 780
            SF+C C  GY  S+ K  C  I          D  ++   CSH  C    G+F+C C  G
Sbjct: 1093 SFRCTCGQGYQLSAAKDQCEDI----------DECEHHHLCSHGQCRNTEGSFQCVCNQG 1142

 Score =  111 bits (278), Expect = 2e-24
 Identities = 75/252 (29%), Positives = 116/252 (46%), Gaps = 33/252 (13%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQ--CDKF- 300
            C  G CIN+  +Y C C   +   +Q + C          +++ A   +L SQ  C+   
Sbjct: 877  CGAGHCINLPVRYTCICYEGYKFSEQLRKCV--------DIDECAQVRHLCSQGRCENTE 928

Query: 301  GSFL---------------------------CKNGRCIESGSSYECK-CNLGFQESSDGK 396
            GSFL                           C++GRCI +  ++ C+ C+ G++ S  G 
Sbjct: 929  GSFLCVCPAGFMASEEGTNCIDVDECLRPDMCRDGRCINTAGAFRCEYCDSGYRMSRRG- 987

Query: 397  ICSDIDECTTNPTICDRGTCINSPGSYQC-SCYDGFTIHNMPGGPKCYDRNECSEDKSLC 573
             C DIDEC   P+ C    C+N+PGSYQC  C +GF   N     +C D +EC + K +C
Sbjct: 988  YCEDIDEC-LKPSTCPEEQCVNTPGSYQCVPCTEGFRGWN----GQCLDVDECLQPK-VC 1041

Query: 574  KNGVCINIHGSFKCQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSH-YCAFVN 750
             NG C N+ GS+ C C+ GY  + + + C  I          D  +  + C +  C   +
Sbjct: 1042 TNGSCTNLEGSYMCSCHRGYSPTPDHRHCQDI----------DECQQGNLCMNGQCRNTD 1091

Query: 751  GTFKCSCPYGME 786
            G+F+C+C  G +
Sbjct: 1092 GSFRCTCGQGYQ 1103

 Score =  109 bits (272), Expect = 1e-23
 Identities = 62/169 (36%), Positives = 81/169 (47%), Gaps = 2/169 (1%)
 Frame = +1

Query: 121  SEQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKF 300
            S  C+GG CIN    Y C C   F                  Q+ND     ++ ++C + 
Sbjct: 1162 SSVCQGGDCINTAGSYDCTCPDGF------------------QLNDNKGCQDI-NECAQP 1202

Query: 301  GSFLC-KNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICD-RGTCINSPGS 474
            G  LC  +G C+ +  S+ C C  GF  S+DG+ C DIDEC  N T+CD  G C N+ GS
Sbjct: 1203 G--LCGSHGECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNN-TVCDSHGFCDNTAGS 1259

Query: 475  YQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQC 621
            ++C CY GF       G  C D NEC     +C    C N+ GSF C C
Sbjct: 1260 FRCLCYQGFQAPQ--DGQGCVDVNECELLSGVCGEAFCENVEGSFLCVC 1306

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 38/91 (41%), Positives = 53/91 (58%)
 Frame = +1

Query: 403  SDIDECTTNPTICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNG 582
            ++I+ECT NP IC  G CIN P  Y C CY+G+         KC D +EC++ + LC  G
Sbjct: 865  TEINECTVNPDICGAGHCINLPVRYTCICYEGYKFSEQL--RKCVDIDECAQVRHLCSQG 922

Query: 583  VCINIHGSFKCQCNSGYVASSNKQDCISIQD 675
             C N  GSF C C +G++AS    +CI + +
Sbjct: 923  RCENTEGSFLCVCPAGFMASEEGTNCIDVDE 953

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 56/198 (28%), Positives = 81/198 (40%), Gaps = 31/198 (15%)
 Frame = +1

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSC 489
            +C  G CI     Y C C  G++ S   + C DIDEC     +C +G C N+ GS+ C C
Sbjct: 876  ICGAGHCINLPVRYTCICYEGYKFSEQLRKCVDIDECAQVRHLCSQGRCENTEGSFLCVC 935

Query: 490  YDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQ-CNSGYVAS-----SNK 651
              GF       G  C D +EC     +C++G CIN  G+F+C+ C+SGY  S      + 
Sbjct: 936  PAGFMASE--EGTNCIDVDECLR-PDMCRDGRCINTAGAFRCEYCDSGYRMSRRGYCEDI 992

Query: 652  QDCISIQDSSDYSAVDDNSKY-CSKCSH------------------------YCAFVNGT 756
             +C+      +   V+    Y C  C+                          C  + G+
Sbjct: 993  DECLKPSTCPEEQCVNTPGSYQCVPCTEGFRGWNGQCLDVDECLQPKVCTNGSCTNLEGS 1052

Query: 757  FKCSCPYGMESILDTGLC 810
            + CSC  G     D   C
Sbjct: 1053 YMCSCHRGYSPTPDHRHC 1070

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 34/91 (37%), Positives = 43/91 (47%), Gaps = 3/91 (3%)
 Frame = +1

Query: 439  CDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSE---DKSLCKNGVCINIHGSF 609
            C+ G C+     Y C C+DG+  H       C D NECSE     SLCKN  CIN  GS+
Sbjct: 1623 CENGRCVRVHEGYTCDCFDGY--HLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSY 1680

Query: 610  KCQCNSGYVASSNKQDCISIQDSSDYSAVDD 702
            KC C  GY+ S     C  +  + +     D
Sbjct: 1681 KCLCLPGYIPSDKPNYCTPLNSALNLDKESD 1711

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 48/182 (26%), Positives = 70/182 (38%), Gaps = 18/182 (9%)
 Frame = +1

Query: 139  GRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSFLCK 318
            G C+N +  + C C   F +   G+ C+   E   N + D+                   
Sbjct: 1209 GECLNTQGSFHCVCEQGFSISADGRTCEDIDECVNNTVCDS------------------- 1249

Query: 319  NGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRGTCINSPGSYQCSCYDG 498
            +G C  +  S+ C C  GFQ   DG+ C D++EC     +C    C N  GS+ C C D 
Sbjct: 1250 HGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADE 1309

Query: 499  FTIHNMPGGPKCYDR---------------NEC---SEDKSLCKNGVCINIHGSFKCQCN 624
               ++ P   +C  R                EC     D SLC N +  N+    +C C 
Sbjct: 1310 NQEYS-PMTGQCRSRVTEDSGVDRQpreEKKECYYNLNDASLCDNVLAPNVTKQ-ECCCT 1367

Query: 625  SG 630
            SG
Sbjct: 1368 SG 1369

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 58/234 (24%), Positives = 96/234 (41%), Gaps = 27/234 (11%)
 Frame = +1

Query: 154  MKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDK-FGSFLCKNGRC 330
            M  Q R     D  +D+Q +  KK   Y    +NDA       S CD      + K   C
Sbjct: 1316 MTGQCRSRVTEDSGVDRQpreEKKECYYN---LNDA-------SLCDNVLAPNVTKQECC 1365

Query: 331  IESGSSYECKCNL------GFQESSD-------------------GKICSDIDECTT-NP 432
              SG+ +   C +      G  E ++                   G+   D DEC     
Sbjct: 1366 CTSGAGWGDNCEIFPCPVQGTAEFTEMCPRGKGLVPAGESSYDTGGENYKDADECLLFGE 1425

Query: 433  TICDRGTCINSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFK 612
             IC  G C+N+   Y+C C  G   +  P   +C+D +EC +D + C +G C+N  GS+ 
Sbjct: 1426 EICKNGYCLNTQPGYECYCKQG--TYYDPVKLQCFDMDEC-QDPNSCIDGQCVNTEGSYN 1482

Query: 613  CQCNSGYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCP 774
            C C    V  ++++ C+   +S++   +++   Y   C  +   ++  + CS P
Sbjct: 1483 CFCTHPMVLDASEKRCVQPTESNE--QIEETDVYQDLCWEH---LSEEYVCSRP 1531

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 3/72 (4%)
 Frame = +1

Query: 313  CKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECT---TNPTICDRGTCINSPGSYQC 483
            C+NGRC+     Y C C  G+        C D++EC+      ++C    CIN+ GSY+C
Sbjct: 1623 CENGRCVRVHEGYTCDCFDGYHLDMAKMTCVDVNECSELNNRMSLCKNAKCINTEGSYKC 1682

Query: 484  SCYDGFTIHNMP 519
             C  G+   + P
Sbjct: 1683 LCLPGYIPSDKP 1694

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 49/239 (20%), Positives = 79/239 (33%), Gaps = 10/239 (4%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C  G+C+N +  Y C C    VLD   + C + TE   N+  +    +           +
Sbjct: 1469 CIDGQCVNTEGSYNCFCTHPMVLDASEKRCVQPTE--SNEQIEETDVYQDLCWEHLSEEY 1526

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKIC--SDIDE--------CTTNPTICDRGTCI 459
            +C      +  +  EC C  G        +C   D D+         T       R   +
Sbjct: 1527 VCSRPLVGKQTTYTECCCLYGEAWGMQCALCPMKDSDDYAQLCNIPVTGRRRPYGRDALV 1586

Query: 460  NSPGSYQCSCYDGFTIHNMPGGPKCYDRNECSEDKSLCKNGVCINIHGSFKCQCNSGYVA 639
            +    Y       F         +     EC      C+NG C+ +H  + C C  GY  
Sbjct: 1587 DFSEQYGPETDPYFIQDRFLNSFEELQAEECGILNG-CENGRCVRVHEGYTCDCFDGYHL 1645

Query: 640  SSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGTFKCSCPYGMESILDTGLCAP 816
               K  C+ + + S+   +++    C      C    G++KC C  G         C P
Sbjct: 1646 DMAKMTCVDVNECSE---LNNRMSLCKNAK--CINTEGSYKCLCLPGYIPSDKPNYCTP 1699

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 26/95 (27%), Positives = 42/95 (44%)
 Frame = +1

Query: 130  CKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFGSF 309
            C+ GRC+ +   Y C+C   + LD     C    E   +++N+  S              
Sbjct: 1623 CENGRCVRVHEGYTCDCFDGYHLDMAKMTCVDVNEC--SELNNRMS-------------- 1666

Query: 310  LCKNGRCIESGSSYECKCNLGFQESSDGKICSDID 414
            LCKN +CI +  SY+C C  G+  S     C+ ++
Sbjct: 1667 LCKNAKCINTEGSYKCLCLPGYIPSDKPNYCTPLN 1701

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 50/174 (28%), Positives = 66/174 (37%), Gaps = 3/174 (1%)
 Frame = +1

Query: 271  FNLKSQCDKFGSFLCKNGRCIESGSSYECKCNLGFQESSDGKICSDIDECTTNPTICDRG 450
            FN   +C K  S+          G +   +C  G++  ++   C DI+EC     +C  G
Sbjct: 584  FNKCQKCPKKQSY---------HGYTQMMECLQGYKRVNN-TFCQDINECQLQG-VCPNG 632

Query: 451  TCINSPGSYQCSCYDGFTIHNMPGGPKCY-DRNECSEDKSLCKNGVCINIHGSFKCQCNS 627
             C+N+ GSY+CSC  GF     P    C  D    SE+K  C   V    H      C  
Sbjct: 633  ECLNTMGSYRCSCKMGFGPD--PTFSSCVPDPPVISEEKGPCYRLVSPGRH------CMH 684

Query: 628  GYVASSNKQDCISIQDSSDYSAVDDNSKYCSKCSHYCAFVNGT--FKCSCPYGM 783
                   KQ C         S       +C KC      + GT  FK  CP GM
Sbjct: 685  PLSVHLTKQICCC-------SVGKAWGPHCEKCP-----LPGTAAFKEICPGGM 726

 Score = 36.2 bits (82), Expect = 0.12
 Identities = 25/80 (31%), Positives = 36/80 (45%)
 Frame = +1

Query: 124  EQCKGGRCINMKNQYRCECLPDFVLDKQGQACKKRTEYKPNQMNDAASSFNLKSQCDKFG 303
            E CK G C+N +  Y C C       KQG      T Y P ++      F++  +C    
Sbjct: 1426 EICKNGYCLNTQPGYECYC-------KQG------TYYDPVKL----QCFDM-DECQDPN 1467

Query: 304  SFLCKNGRCIESGSSYECKC 363
            S  C +G+C+ +  SY C C
Sbjct: 1468 S--CIDGQCVNTEGSYNCFC 1485
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,137,411
Number of Sequences: 369166
Number of extensions: 2197959
Number of successful extensions: 13787
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5957
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8615
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8838279920
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)