Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01837
(788 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8IPH9|SLOB_DROME Slowpoke-binding protein 65 3e-10
sp|P41743|KPCI_HUMAN Protein kinase C, iota type (nPKC-iota... 50 9e-06
sp|Q62074|KPCI_MOUSE Protein kinase C, iota type (nPKC-iota... 50 9e-06
sp|Q5R4K9|KPCI_PONPY Protein kinase C, iota type (nPKC-iota) 50 9e-06
sp|Q90XF2|KPCI_BRARE Protein kinase C, iota type (nPKC-iota... 50 9e-06
sp|P13678|KPC3_DROME Protein kinase C (PKC) (dPKC98F) 48 3e-05
sp|Q05513|KPCZ_HUMAN Protein kinase C, zeta type (nPKC-zeta) 47 6e-05
sp|P54644|KRAC_DICDI RAC-family serine/threonine-protein ki... 47 6e-05
sp|P09217|KPCZ_RAT Protein kinase C, zeta type (nPKC-zeta) 47 6e-05
sp|Q02956|KPCZ_MOUSE Protein kinase C, zeta type (nPKC-zeta) 47 6e-05
>sp|Q8IPH9|SLOB_DROME Slowpoke-binding protein
Length = 515
Score = 64.7 bits (156), Expect = 3e-10
Identities = 63/221 (28%), Positives = 103/221 (46%), Gaps = 10/221 (4%)
Frame = +1
Query: 43 IIRLFSELGSLHDFMCKVKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGI 222
++ F+ GSL D + K + P KY + ++ + GRQIL L +L ++G
Sbjct: 262 LVTPFNSRGSLKDLIYKAQWNEPWARKYT-RKPNGLPVSQVQRLGRQILEALLFLKERGF 320
Query: 223 P-YGHLHLRNVLLFTEDRCGLTDIENSVLGLIPQDRHFYVGILKKLT-FEEIDIYCFGRI 396
P +GHLH NV+L L+ +EN +LGL R V + +T E +DI CFG +
Sbjct: 321 PLHGHLHSGNVIL-QNGAARLSGLENGLLGL--SSRINAVMWSRSVTEIENVDIVCFGHL 377
Query: 397 MYEMIFGE----PLNSTFIISDDKLKWPTPAIREFMFSVLTEVVLK--SGF-PTIDNLLE 555
+YEM G+ P S ++ + +P + ++ + SG P++++L+
Sbjct: 378 LYEMCTGQELTTPKPSMRVLEMELQHYPQIGQTRKQILEILGLIFEPPSGVCPSVEDLVL 437
Query: 556 LTLFKSCSPKLIDKSPFK-ISPSCKELLLSTQQYSLKRLIA 675
LF+S + + F I PS L+ Q KR A
Sbjct: 438 CDLFRSIDLRELRGPCFSTIKPSLSRSTLNLLQAVKKRQCA 478
>sp|P41743|KPCI_HUMAN Protein kinase C, iota type (nPKC-iota) (Atypical protein kinase
C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota)
Length = 587
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Frame = +1
Query: 94 VKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDR 273
++ VN L +++Q + H + +I L L YLH++GI Y L L NVLL +E
Sbjct: 323 IEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGH 382
Query: 274 CGLTDIENSVLGLIPQD-RHFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
LTD GL P D + G + E +D + G +M+EM+ G
Sbjct: 383 IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRS 442
Query: 424 LNSTFIISDDKLKWPTPAIREFMFSVLTE 510
SD+ P +++F V+ E
Sbjct: 443 PFDIVGSSDN----PDQNTEDYLFQVILE 467
>sp|Q62074|KPCI_MOUSE Protein kinase C, iota type (nPKC-iota) (Atypical protein kinase
C-lambda/iota) (aPKC-lambda/iota)
Length = 586
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Frame = +1
Query: 94 VKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDR 273
++ VN L +++Q + H + +I L L YLH++GI Y L L NVLL +E
Sbjct: 322 IEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGH 381
Query: 274 CGLTDIENSVLGLIPQD-RHFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
LTD GL P D + G + E +D + G +M+EM+ G
Sbjct: 382 IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRS 441
Query: 424 LNSTFIISDDKLKWPTPAIREFMFSVLTE 510
SD+ P +++F V+ E
Sbjct: 442 PFDIVGSSDN----PDQNTEDYLFQVILE 466
>sp|Q5R4K9|KPCI_PONPY Protein kinase C, iota type (nPKC-iota)
Length = 587
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Frame = +1
Query: 94 VKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDR 273
++ VN L +++Q + H + +I L L YLH++GI Y L L NVLL +E
Sbjct: 323 IEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGH 382
Query: 274 CGLTDIENSVLGLIPQD-RHFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
LTD GL P D + G + E +D + G +M+EM+ G
Sbjct: 383 IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRS 442
Query: 424 LNSTFIISDDKLKWPTPAIREFMFSVLTE 510
SD+ P +++F V+ E
Sbjct: 443 PFDIVGSSDN----PDQNTEDYLFQVILE 467
>sp|Q90XF2|KPCI_BRARE Protein kinase C, iota type (nPKC-iota) (Atypical protein kinase
C-lambda/iota) (aPKC-lambda/iota) (Heart and soul
protein)
Length = 588
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Frame = +1
Query: 94 VKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDR 273
++ VN L +++Q + H + +I L L YLH++GI Y L L NVLL +E
Sbjct: 324 IEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGH 383
Query: 274 CGLTDIENSVLGLIPQD-RHFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
LTD GL P D + G + E +D + G +M+EM+ G
Sbjct: 384 IKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRS 443
Query: 424 LNSTFIISDDKLKWPTPAIREFMFSVLTE 510
SD+ P +++F V+ E
Sbjct: 444 PFDIVGSSDN----PDQNTEDYLFQVILE 468
>sp|P13678|KPC3_DROME Protein kinase C (PKC) (dPKC98F)
Length = 634
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 10/117 (8%)
Frame = +1
Query: 103 VNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDRCGL 282
VN L + +Q + + + + ++ L L++LH G+ Y L L N+LL E C L
Sbjct: 384 VNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKL 443
Query: 283 TD-------IENSVLGLIPQDRHFYVG--ILKKLTF-EEIDIYCFGRIMYEMIFGEP 423
D I N +L Y+ ILK+ + +D + G +MYEM+ G+P
Sbjct: 444 ADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQP 500
>sp|Q05513|KPCZ_HUMAN Protein kinase C, zeta type (nPKC-zeta)
Length = 592
Score = 47.0 bits (110), Expect = 6e-05
Identities = 41/149 (27%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Frame = +1
Query: 94 VKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDR 273
++ VN L +++Q + H + +I + L +LH++GI Y L L NVLL +
Sbjct: 330 IEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGH 389
Query: 274 CGLTDIENSVLGLIPQD-RHFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
LTD GL P D + G + E +D + G +M+EM+ G
Sbjct: 390 IKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAG-- 447
Query: 424 LNSTFIISDDKLKWPTPAIREFMFSVLTE 510
S F I D P +++F V+ E
Sbjct: 448 -RSPFDIITDN---PDMNTEDYLFQVILE 472
>sp|P54644|KRAC_DICDI RAC-family serine/threonine-protein kinase homolog
Length = 444
Score = 47.0 bits (110), Expect = 6e-05
Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 11/118 (9%)
Frame = +1
Query: 103 VNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDRCGL 282
VN L Y++Q K + + +G +I+L L++LH G+ Y L N+LL E +
Sbjct: 200 VNGGELFYHLQKDKKFTEDRVRYYGAEIVLALEHLHLSGVIYRDLKPENLLLTNEGHICM 259
Query: 283 TDIENSVLGLI-PQDR-HFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
TD GL+ P D+ + G + L E ++D + FG ++YEM+ G P
Sbjct: 260 TDFGLCKEGLLTPTDKTGTFCGTPEYLAPEVLQGNGYGKQVDWWSFGSLLYEMLTGLP 317
>sp|P09217|KPCZ_RAT Protein kinase C, zeta type (nPKC-zeta)
Length = 592
Score = 47.0 bits (110), Expect = 6e-05
Identities = 41/149 (27%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Frame = +1
Query: 94 VKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDR 273
++ VN L +++Q + H + +I + L +LH++GI Y L L NVLL +
Sbjct: 330 IEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGH 389
Query: 274 CGLTDIENSVLGLIPQD-RHFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
LTD GL P D + G + E +D + G +M+EM+ G
Sbjct: 390 IKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAG-- 447
Query: 424 LNSTFIISDDKLKWPTPAIREFMFSVLTE 510
S F I D P +++F V+ E
Sbjct: 448 -RSPFDIITDN---PDMNTEDYLFQVILE 472
>sp|Q02956|KPCZ_MOUSE Protein kinase C, zeta type (nPKC-zeta)
Length = 592
Score = 47.0 bits (110), Expect = 6e-05
Identities = 41/149 (27%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Frame = +1
Query: 94 VKPVNPIILKYNVQNGKSTLINHLSLFGRQILLGLKYLHDKGIPYGHLHLRNVLLFTEDR 273
++ VN L +++Q + H + +I + L +LH++GI Y L L NVLL +
Sbjct: 330 IEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGH 389
Query: 274 CGLTDIENSVLGLIPQD-RHFYVGILKKLTFE---------EIDIYCFGRIMYEMIFGEP 423
LTD GL P D + G + E +D + G +M+EM+ G
Sbjct: 390 IKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAG-- 447
Query: 424 LNSTFIISDDKLKWPTPAIREFMFSVLTE 510
S F I D P +++F V+ E
Sbjct: 448 -RSPFDIITDN---PDMNTEDYLFQVILE 472
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,803,097
Number of Sequences: 369166
Number of extensions: 1936519
Number of successful extensions: 6420
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5988
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6258
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)