Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01775
(847 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ES88|S13A2_MOUSE Solute carrier family 13 member 2 (Re... 104 3e-22
sp|Q28615|S13A2_RABIT Solute carrier family 13 member 2 (Re... 104 3e-22
sp|Q8WWT9|S13A3_HUMAN Solute carrier family 13 member 3 (So... 103 6e-22
sp|Q13183|S13A2_HUMAN Solute carrier family 13 member 2 (Re... 100 7e-21
sp|Q9Z0Z5|S13A3_RAT Solute carrier family 13 member 3 (Sodi... 92 2e-18
sp|Q91Y63|S13A3_MOUSE Solute carrier family 13 member 3 (So... 91 3e-18
sp|Q9UKG4|S13A4_HUMAN Solute carrier family 13 member 4 (Na... 87 4e-17
sp|Q93655|NAD1_CAEEL Sodium-dependent low-affinity dicarbox... 87 6e-17
sp|Q07782|S13A1_RAT Solute carrier family 13 member 1 (Rena... 84 5e-16
sp|P70545|S13A2_RAT Solute carrier family 13 member 2 (Inte... 82 2e-15
>sp|Q9ES88|S13A2_MOUSE Solute carrier family 13 member 2 (Renal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 586
Score = 104 bits (260), Expect = 3e-22
Identities = 86/293 (29%), Positives = 135/293 (46%), Gaps = 13/293 (4%)
Frame = +2
Query: 8 TKPLLCFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKI-EASQIITESYASDSLFLCL 184
TK C Y ++L+A W + LP +T+L PI+ PLM I EAS++ E Y D+ L +
Sbjct: 33 TKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLE-YFKDTNILFV 91
Query: 185 GRLILACAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEF 364
G L++A A + +H+R +L +L G +P +++L M+ L+M+IS AT +ML
Sbjct: 92 GGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPI 151
Query: 365 VIEILQELQKIDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYPSMTNV 544
+L++LQ G+Q + E + + P + T D+ +++
Sbjct: 152 GYAVLEQLQ----GSQKDVEEGNSNPSFELQEASPQKEE---------TKLDNGQAVS-- 196
Query: 545 LEKMKEVSIKKRAQINQYNEEQNEKFKRFSLALSLCTGYAASCGAVATLVASGCNLVAYG 724
VS + RAQ + ++ RFS LSLC Y+AS G +ATL + NLV G
Sbjct: 197 ------VSSEPRAQ-------KTKEHHRFSQGLSLCICYSASIGGIATLTGTTPNLVLQG 243
Query: 725 ------------VLVKYWFTIKFSLYY*FNLYGLVCCKIDLIPVLFNKMQNFG 847
V WF F L + ++ + V F K FG
Sbjct: 244 QVNSIFPENSNVVNFASWFGFAFPTMVILLLLAWLWLQVLFLGVNFRKNFGFG 296
>sp|Q28615|S13A2_RABIT Solute carrier family 13 member 2 (Renal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 593
Score = 104 bits (260), Expect = 3e-22
Identities = 82/296 (27%), Positives = 132/296 (44%), Gaps = 17/296 (5%)
Frame = +2
Query: 11 KPLLCFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKI-EASQIITESYASDSLFLCLG 187
K C Y ++L+A FW D LP +T+L+P+ P+M I EAS++ E Y D+ L +G
Sbjct: 34 KEAYCAYAIILMALFWCTDALPLAVTALLPLCLFPMMGIMEASEVGLE-YLKDTNVLFIG 92
Query: 188 RLILACAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEFV 367
L+LA A + +H+R +L +L G +P ++IL M+ L+M+IS A+ +M+
Sbjct: 93 GLLLAIAVEHWNLHKRIALRVLLLTGVRPALLILGFMVVTAFLSMWISNTASTAMMVPIA 152
Query: 368 IEILQELQK----IDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYPSM 535
+LQEL ++EG+ E Q + T ++ + Q L ++ +
Sbjct: 153 HAVLQELNNTQSNVEEGSDNPTFELQEPSPQKETSKVDEKDNGQAQPLPAVPLES----- 207
Query: 536 TNVLEKMKEVSIKKRAQINQYNEEQNEKFKRFSLALSLCTGYAASCGAVATLVASGCNLV 715
E ++ RFS +SLC Y+AS G +ATL + NLV
Sbjct: 208 ---------------------GEHMTQEQLRFSQGMSLCVCYSASIGGIATLTGTTPNLV 246
Query: 716 AYGVLVKY------------WFTIKFSLYY*FNLYGLVCCKIDLIPVLFNKMQNFG 847
G + WF F + L + +I + + F K NFG
Sbjct: 247 LQGQMTSLFPQNPNVVNFASWFGFAFPIMVILLLLSWLWLQILFLGINFRK--NFG 300
>sp|Q8WWT9|S13A3_HUMAN Solute carrier family 13 member 3 (Sodium-dependent high-affinity
dicarboxylate transporter 2) (Na(+)/dicarboxylate
cotransporter 3) (NaDC-3) (hNaDC3)
Length = 602
Score = 103 bits (257), Expect = 6e-22
Identities = 74/266 (27%), Positives = 118/266 (44%), Gaps = 11/266 (4%)
Frame = +2
Query: 23 CFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKIEASQIITESYASDSLFLCLGRLILA 202
C ++++L+A +W + LP +T+L+PI+ P M I S + Y D+ FL L LI+A
Sbjct: 41 CLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFLSGLIMA 100
Query: 203 CAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEFVIEILQ 382
A + +HRR +L +L G QP +IL M+ L+M++S A+ +ML IL+
Sbjct: 101 SAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIANAILK 160
Query: 383 ELQKIDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYPSMTNVLEKMKE 562
L + DP + + R + + T D+P T E
Sbjct: 161 SL--FGQKEVRKDPSQESEENTAAVRRNGLHTVPTEMQFLASTEAKDHPGET-------E 211
Query: 563 VSIKKRAQINQYNEEQNEKFKRFSLALSLCTGYAASCGAVATLVASGCNLVAYGVLVKY- 739
V + A + +E + +K F +++ Y+AS G ATL + NL+ G L +
Sbjct: 212 VPLDLPADSRKEDEYRRNIWKGFLISIP----YSASIGGTATLTGTAPNLILLGQLKSFF 267
Query: 740 ----------WFTIKFSLYY*FNLYG 787
WF F L F L G
Sbjct: 268 PQCDVVNFGSWFIFAFPLMLLFLLAG 293
>sp|Q13183|S13A2_HUMAN Solute carrier family 13 member 2 (Renal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 592
Score = 100 bits (248), Expect = 7e-21
Identities = 76/292 (26%), Positives = 127/292 (43%), Gaps = 12/292 (4%)
Frame = +2
Query: 8 TKPLLCFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKIEASQIITESYASDSLFLCLG 187
+K C Y ++L+A FW + LP +T+L P++ P+M I + + Y DS L G
Sbjct: 33 SKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFG 92
Query: 188 RLILACAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEFV 367
L++A A + +H+R +L +L G +P +IL M+ L+M+IS AT+ +M+
Sbjct: 93 GLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIA 152
Query: 368 IEILQELQKIDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYPSMTNVL 547
+L +L + + + N P Q +T D+ ++
Sbjct: 153 HAVLDQLHSSQASSNVEEGSNN-----------PTFELQEPSPQKEVTKLDNGQAL---- 197
Query: 548 EKMKEVSIKKRAQINQYNEEQNEKFKRFSLALSLCTGYAASCGAVATLVASGCNLVAYG- 724
+ S + RA ++Q K + +SLC Y+AS G +ATL + NLV G
Sbjct: 198 -PVTSASSEGRAHLSQ-------KHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQ 249
Query: 725 -----------VLVKYWFTIKFSLYY*FNLYGLVCCKIDLIPVLFNKMQNFG 847
V WF+ F L L + ++ + FN +NFG
Sbjct: 250 INSLFPQNGNVVNFASWFSFAFPTMVILLL--LAWLWLQILFLGFNFRKNFG 299
>sp|Q9Z0Z5|S13A3_RAT Solute carrier family 13 member 3 (Sodium-dependent high-affinity
dicarboxylate transporter 2) (Na(+)/dicarboxylate
cotransporter 3) (NaDC-3) (rNaDC3)
Length = 600
Score = 92.0 bits (227), Expect = 2e-18
Identities = 71/274 (25%), Positives = 118/274 (43%), Gaps = 19/274 (6%)
Frame = +2
Query: 23 CFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKIEASQIITESYASDSLFLCLGRLILA 202
C Y+++L+A +W + LP +T+L+PI+ P M I S + Y D+ FL L LI+A
Sbjct: 41 CLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCPQYFLDTNFLFLSGLIMA 100
Query: 203 CAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEFVIEILQ 382
A + +HRR +L +L G QP +IL M+ L+M++S A+ +ML IL+
Sbjct: 101 SAIEERNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIASAILK 160
Query: 383 ELQKIDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYPSMTNVLEKMKE 562
L +G D L ++ ++ N + V +M+
Sbjct: 161 SL-------------------FGQRDTRKDLpreGEDSTAAVRGN----GLRTVPTEMQF 197
Query: 563 VSIKK-------RAQINQYNEEQNEKFKR-FSLALSLCTGYAASCGAVATLVASGCNLVA 718
++ + A + ++ + E+ +R + Y+AS G ATL + NL+
Sbjct: 198 LASSEGGHAEDVEAPLELPDDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLIL 257
Query: 719 YGVLVKY-----------WFTIKFSLYY*FNLYG 787
G L + WF F L F L G
Sbjct: 258 LGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLVG 291
>sp|Q91Y63|S13A3_MOUSE Solute carrier family 13 member 3 (Sodium-dependent high-affinity
dicarboxylate transporter 2) (Na(+)/dicarboxylate
cotransporter 3) (NaDC-3) (mNaDC3)
Length = 600
Score = 91.3 bits (225), Expect = 3e-18
Identities = 69/270 (25%), Positives = 116/270 (42%), Gaps = 15/270 (5%)
Frame = +2
Query: 23 CFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKIEASQIITESYASDSLFLCLGRLILA 202
C Y+++L+A +W + LP +T+L+PI+ P M I S + Y D+ FL L LI+A
Sbjct: 41 CLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCPQYFLDTNFLFLSGLIMA 100
Query: 203 CAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEFVIEILQ 382
A + +HRR +L +L G QP +IL M+ L+M++S A+ +ML IL+
Sbjct: 101 SAIEEWNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIASAILK 160
Query: 383 ELQKIDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMND--DYPSMTNVLEKM 556
L +G + L ++ ++ ++ N P+ L
Sbjct: 161 SL-------------------FGQREARKDLpreGDESTAAVQGNGLRTVPTEMQFLASS 201
Query: 557 KEVSIKKRAQINQYNEEQNEKFKRFSL--ALSLCTGYAASCGAVATLVASGCNLVAYGVL 730
+ + + ++ E+ R ++ + Y+AS G ATL + NL+ G L
Sbjct: 202 EGGHTEDAEAPMELPDDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQL 261
Query: 731 VKY-----------WFTIKFSLYY*FNLYG 787
+ WF F L F L G
Sbjct: 262 KSFFPQCDVVNFGSWFIFAFPLMLLFLLVG 291
>sp|Q9UKG4|S13A4_HUMAN Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter
SUT-1)
Length = 627
Score = 87.4 bits (215), Expect = 4e-17
Identities = 60/264 (22%), Positives = 126/264 (47%), Gaps = 26/264 (9%)
Frame = +2
Query: 2 HSTKPLLCFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKIEASQIITESYASDSLFLC 181
H + C Y+L++ A +W + +P G +L+P P + S + Y ++ L
Sbjct: 30 HPSSEASCAYVLIVTAVYWVSEAVPLGAAALVPAFLYPFFGVLRSNEVAAEYFKNTTLLL 89
Query: 182 LGRLILACAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLE 361
+G + +A A ++ +H+R +L ++ G +P M++L M +L+M++S +T +++
Sbjct: 90 VGVICVAAAVEKWNLHKRIALRMVLMAGAKPGMLLLCFMCCTTLLSMWLSNTSTTAMVMP 149
Query: 362 FVIEILQEL-----QKIDEGNQLNDPENQGFTDYGTT----DRIPILNQQNNQDLCSLTM 514
V +LQEL +++ GN + D + + I + ++N DL +L
Sbjct: 150 IVEAVLQELVSAEDEQLVAGNSNTEEAEPISLDVKNSQPSLELIFVNEDRSNADLTTLMH 209
Query: 515 NDD---YPSMTNVLEKMKEVSIKK------RAQI---NQYNEEQNEKFK-----RFSLAL 643
N++ PS+TN ++ + KK + Q+ + ++ N K++ L
Sbjct: 210 NENLNGVPSITNPIKTANQHQGKKQHPSQEKPQVLTPSPRKQKLNRKYRSHHDQMICKCL 269
Query: 644 SLCTGYAASCGAVATLVASGCNLV 715
SL Y+A+ G + T++ + +L+
Sbjct: 270 SLSISYSATIGGLTTIIGTSTSLI 293
>sp|Q93655|NAD1_CAEEL Sodium-dependent low-affinity dicarboxylate transporter 1
(Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (ceNaDC1)
Length = 582
Score = 87.0 bits (214), Expect = 6e-17
Identities = 59/239 (24%), Positives = 112/239 (46%), Gaps = 3/239 (1%)
Frame = +2
Query: 23 CFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKIEASQIITESYASDSLFLCLGRLILA 202
C Y + ++ ++W + LP IT+ IP++ PL I S+ + +Y D+ FL +G L++A
Sbjct: 44 CLYCVAVMGSYWVFEALPLAITAFIPMILFPLFGIMRSEEVARAYLPDTCFLFMGGLMVA 103
Query: 203 CAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEFVIEILQ 382
A ++ ++H R +LF+L G +P ++ M L+M+IS AT +M+ + ++
Sbjct: 104 LAVEKCELHARVALFVLKTVGSEPARVMAGFMGVTGFLSMWISNTATTALMVPILQSVIT 163
Query: 383 EL---QKIDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYPSMTNVLEK 553
EL ++++ L + + + R L +NN+
Sbjct: 164 ELVSNHRMEDLVALCEAHHNSSRKHSVGMRRLSLPNENNE-------------------- 203
Query: 554 MKEVSIKKRAQINQYNEEQNEKFKRFSLALSLCTGYAASCGAVATLVASGCNLVAYGVL 730
KR +++ + +K + L LS+C ++A+ G AT+ + NLV G L
Sbjct: 204 ------IKREEMDTAMSpreQKMAK-GLMLSVC--FSANIGGAATITGTASNLVLVGQL 253
>sp|Q07782|S13A1_RAT Solute carrier family 13 member 1 (Renal sodium/sulfate
cotransporter) (Na(+)/sulfate cotransporter) (NaSi-1)
Length = 595
Score = 84.0 bits (206), Expect = 5e-16
Identities = 61/244 (25%), Positives = 116/244 (47%), Gaps = 8/244 (3%)
Frame = +2
Query: 8 TKPLLCFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKIEASQIITESYASDSLFLCLG 187
+K C Y+L ++A FW + LP IT+L+P L P+ I +S + +Y D L +G
Sbjct: 32 SKEAECAYILFVIATFWITEALPLSITALLPGLMFPMFGIMSSTHVASAYFKDFHLLLIG 91
Query: 188 RLILACAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEFV 367
+ LA + ++ +H+R +L ++ G P + L M L+M++S +TA +++ V
Sbjct: 92 VICLATSIEKWNLHKRIALRMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIV 151
Query: 368 IEILQELQKID---EGNQL---NDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYP 529
+ Q++ + E Q+ N+ QG T I+ Q+ N+ P
Sbjct: 152 EAVAQQITSAEAEAEATQMTYFNESAAQGLEVDET-----IIGQETNE-----RKEKTKP 201
Query: 530 SMTNVLEKMKEVSIKKRAQINQYN--EEQNEKFKRFSLALSLCTGYAASCGAVATLVASG 703
++ + +K K VS K + N + +++K + LC Y+++ G + T+ +
Sbjct: 202 ALGSSNDKGK-VSSKMETEKNTVTGAKYRSKKDHMMCKLMCLCIAYSSTIGGLTTITGTS 260
Query: 704 CNLV 715
NL+
Sbjct: 261 TNLI 264
>sp|P70545|S13A2_RAT Solute carrier family 13 member 2 (Intestinal sodium/dicarboxylate
cotransporter) (Na(+)/dicarboxylate cotransporter 1)
(NaDC-1)
Length = 587
Score = 81.6 bits (200), Expect = 2e-15
Identities = 76/296 (25%), Positives = 126/296 (42%), Gaps = 16/296 (5%)
Frame = +2
Query: 8 TKPLLCFYMLVLLAAFWSLDVLPYGITSLIPILFAPLMKI-EASQIITESYASDSLFLCL 184
TK C Y ++L+A W + LP +T L PI+ LM I +AS+ + Y D+ L +
Sbjct: 33 TKEAYCAYSIILMALLWCTEALPLAVTVLFPIVLFLLMGIMDASEGL--EYFKDTNILFV 90
Query: 185 GRLILACAYKRHQIHRRFSLFLLTKFGPQPRMIILSCMIPCYILTMFISKAATAPIMLEF 364
G L++A A + +H+R +L +L G + +++L M+ L+M+IS AT +M+
Sbjct: 91 GGLMVAIAVEHWNLHKRIALQVLLIIGVRAALLLLGFMLVTAFLSMWISNTATTAMMVPI 150
Query: 365 VIEILQELQ--KIDEGNQLNDPENQGFTDYGTTDRIPILNQQNNQDLCSLTMNDDYPSM- 535
+L++LQ K D N+P + + ++ P
Sbjct: 151 GHAVLEQLQASKKDVEGGNNNP--------------------------TFELQEECPQKE 184
Query: 536 TNVLEKMKEVSIKKRAQINQYNEEQNEKFKRFSLALSLCTGYAASCGAVATLVASGCNLV 715
L+ + VS ++ ++ ++ RFS LSLC Y+AS G + L + NLV
Sbjct: 185 VTKLDNGQPVSAP-----SEPRTQKTQEHHRFSQGLSLCICYSASIGGIDNLTGTTPNLV 239
Query: 716 AYG------------VLVKYWFTIKFSLYY*FNLYGLVCCKIDLIPVLFNKMQNFG 847
G V WF F L + ++ + V F K FG
Sbjct: 240 LQGQVNSLFPQNANVVNFASWFGFAFPTMIILLLLAWLWLQVLFLGVNFRKNFGFG 295
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,303,260
Number of Sequences: 369166
Number of extensions: 1452513
Number of successful extensions: 4041
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3925
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4035
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)