Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01769
(804 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P17812|PYRG_HUMAN CTP synthase (UTP--ammonia ligase) (CT... 284 2e-76
sp|P70698|PYRG_MOUSE CTP synthase (UTP--ammonia ligase) (CT... 276 5e-74
sp|Q7RZV2|PYRG_NEUCR CTP synthase (UTP--ammonia ligase) (CT... 259 5e-69
sp|O42644|PYRG_SCHPO CTP synthase (UTP--ammonia ligase) (CT... 259 8e-69
sp|Q6FUD0|PYRG_CANGA CTP synthase (UTP--ammonia ligase) (CT... 246 4e-65
sp|O74638|PYRG_GIBZE CTP synthase (UTP--ammonia ligase) (CT... 244 2e-64
sp|Q751L7|PYRG_ASHGO CTP synthase (UTP--ammonia ligase) (CT... 243 4e-64
sp|P28274|URA7_YEAST CTP synthase 1 (UTP--ammonia ligase 1)... 241 2e-63
sp|Q8R720|PYRG_THETN CTP synthase (UTP--ammonia ligase) (CT... 225 1e-58
sp|Q8TYT7|PYRG_METKA CTP synthase (UTP--ammonia ligase) (CT... 217 3e-56
>sp|P17812|PYRG_HUMAN CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 591
Score = 284 bits (726), Expect = 2e-76
Identities = 145/268 (54%), Positives = 180/268 (67%), Gaps = 2/268 (0%)
Frame = +1
Query: 1 PKKDLYKWKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQV 180
P+K L KWK + D+ + L +I LVGKY D+Y SV KAL H+AL N KL + +
Sbjct: 278 PRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYI 337
Query: 181 NAEHL--IESNDKNIEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILG 354
++ L I S ++ + Y EAW+K+ A GV+VPGGFG RG EGKI AI + R K P LG
Sbjct: 338 DSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLG 397
Query: 355 VCLGMQCQVIEFARNVLGMCDAHSEEFDPDTKHKVVIEMPEFNPSQKGGTMRLGKRETFF 534
VCLGMQ V+EF+RNVLG DA+S EFDP T H VV++MPE NP Q GGTMRLGKR T F
Sbjct: 398 VCLGMQLAVVEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLF 457
Query: 535 HTKNQFLNGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKA 714
TKN SV+ LY + +EERHRHR+EVN + + E +G+ FVG+D
Sbjct: 458 QTKN------------SVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVE 505
Query: 715 EERMEILELNDHPYFVGVQYHPEYLSRP 798
ERMEI+EL DHP+FVGVQYHPE+LSRP
Sbjct: 506 GERMEIVELEDHPFFVGVQYHPEFLSRP 533
>sp|P70698|PYRG_MOUSE CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 591
Score = 276 bits (706), Expect = 5e-74
Identities = 143/267 (53%), Positives = 178/267 (66%), Gaps = 2/267 (0%)
Frame = +1
Query: 4 KKDLYKWKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVN 183
+K L KWK + D+ + L +I LVGKY D+Y SV KAL H+AL N KL + ++
Sbjct: 279 RKMLMKWKEMADRYDRLLETCSIALVGKYPKFSDSYASVIKALEHSALAINHKLEIKYID 338
Query: 184 AEHLIESN--DKNIEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGV 357
+ L S ++ + Y EAW+K+ A GV+VPGGFG RG EGKI AI + R+ K P LGV
Sbjct: 339 STDLEPSTLQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWSRKQKKPFLGV 398
Query: 358 CLGMQCQVIEFARNVLGMCDAHSEEFDPDTKHKVVIEMPEFNPSQKGGTMRLGKRETFFH 537
CLG+Q V+EF+RNVLG DA+S EFDP T H VVI+MPE NP Q GGTMRLGKR T F
Sbjct: 399 CLGIQLAVVEFSRNVLGWQDANSTEFDPKTSHPVVIDMPEHNPGQMGGTMRLGKRRTLFQ 458
Query: 538 TKNQFLNGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAE 717
TKN SV+ LY + +EERHRHR+EVN + E +G+ FVG+D
Sbjct: 459 TKN------------SVMRKLYGDTDYLEERHRHRFEVNPVLKKCLEEQGLKFVGQDVEG 506
Query: 718 ERMEILELNDHPYFVGVQYHPEYLSRP 798
ERMEI+EL DHP+FVGVQYHPE+LSRP
Sbjct: 507 ERMEIVELEDHPFFVGVQYHPEFLSRP 533
>sp|Q7RZV2|PYRG_NEUCR CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 568
Score = 259 bits (663), Expect = 5e-69
Identities = 133/246 (54%), Positives = 167/246 (67%), Gaps = 2/246 (0%)
Frame = +1
Query: 64 VNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVNAEHLIESNDKN--IEYLEAW 237
V+IVLVGKYV L DAY+SV KAL H+A+ C KL + V++EHL E K +Y +AW
Sbjct: 291 VDIVLVGKYVELHDAYLSVIKALEHSAMRCGRKLNLIWVDSEHLEEKTQKEDPTKYHKAW 350
Query: 238 KKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCLGMQCQVIEFARNVLGMCD 417
V VA G++VPGGFG RG EG I A ++ RE K P LGVCLGMQ VIE ARN+ + D
Sbjct: 351 HDVCVAKGILVPGGFGHRGTEGMIRAAQWAREQKTPFLGVCLGMQVAVIEAARNLCELKD 410
Query: 418 AHSEEFDPDTKHKVVIEMPEFNPSQKGGTMRLGKRETFFHTKNQFLNGAEIGSNHSVIHY 597
A SEEFD + +H+V+I MPE + + GGTMRLG R T F + GS S +
Sbjct: 411 ATSEEFDANAEHRVIIFMPEGSKEKLGGTMRLGTRSTHF----------QPGSEFSKLRA 460
Query: 598 LYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAEERMEILELNDHPYFVGVQYH 777
LY +IEERHRHRYEVN D++E E G+ F+G+D + ERME++E+ DHPY+VGVQYH
Sbjct: 461 LYGEATTIEERHRHRYEVNPDYIEKLEQSGLIFIGKDDSGERMEVVEIKDHPYYVGVQYH 520
Query: 778 PEYLSR 795
PEY SR
Sbjct: 521 PEYTSR 526
>sp|O42644|PYRG_SCHPO CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 600
Score = 259 bits (661), Expect = 8e-69
Identities = 132/261 (50%), Positives = 172/261 (65%), Gaps = 2/261 (0%)
Frame = +1
Query: 22 WKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVNAEHLIE 201
WK L ++V IVLVGKY +L+D+YISV KAL H+A+ C KL + V A HL
Sbjct: 289 WKHLTQGYDHLFKKVTIVLVGKYTHLQDSYISVIKALEHSAMRCGRKLDLQWVEASHLEA 348
Query: 202 SNDKN--IEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCLGMQC 375
S + + + Y +AW V A G++VPGGFG RG+EG IAA K+ REN P LG+CLGMQ
Sbjct: 349 STNTSDPLSYHKAWHLVCSANGILVPGGFGSRGVEGMIAAAKWARENNTPYLGICLGMQV 408
Query: 376 QVIEFARNVLGMCDAHSEEFDPDTKHKVVIEMPEFNPSQKGGTMRLGKRETFFHTKNQFL 555
VIEFAR+V G+ A SEEFD + ++ VV+ MPE + + GGTMRLG R TFF +++
Sbjct: 409 AVIEFARSVCGIEGAFSEEFDKECENNVVVYMPEIDKDKLGGTMRLGLRPTFFQPNSEW- 467
Query: 556 NGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAEERMEIL 735
S + L+ V + ERHRHRYE+N F+ E G++F+G+D+ ERMEI+
Sbjct: 468 ---------SKLRKLHKMVDEVLERHRHRYEINPAFVSRLEQGGISFIGKDERGERMEII 518
Query: 736 ELNDHPYFVGVQYHPEYLSRP 798
E DHPYFVGVQYHPEYLS+P
Sbjct: 519 EKRDHPYFVGVQYHPEYLSKP 539
>sp|Q6FUD0|PYRG_CANGA CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 578
Score = 246 bits (629), Expect = 4e-65
Identities = 128/265 (48%), Positives = 170/265 (64%), Gaps = 4/265 (1%)
Frame = +1
Query: 13 LYKWKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVNAEH 192
L KWK + S+ V I LVGKY NL+D+Y+SV KAL H+++ C KL + V A
Sbjct: 287 LSKWKSMTGNFDSSMETVKIALVGKYTNLKDSYLSVIKALEHSSMKCRRKLEIMWVEATD 346
Query: 193 LI-ESND-KNIEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCLG 366
L E+ D + ++ EAW KVS A G++VPGGFG RG EG + A ++ REN +P LGVCLG
Sbjct: 347 LEPETQDTEKAKFHEAWNKVSTADGILVPGGFGSRGTEGMMLASRWARENHIPFLGVCLG 406
Query: 367 MQCQVIEFARNVLGMCDAHSEEFDP--DTKHKVVIEMPEFNPSQKGGTMRLGKRETFFHT 540
+Q IEFARNVLG+ + +S EF P D ++VV+ MPE + GG+MRLG R T+F
Sbjct: 407 LQIATIEFARNVLGVKEGNSAEFFPELDESNQVVVFMPEIDKETMGGSMRLGLRPTYFQQ 466
Query: 541 KNQFLNGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAEE 720
G+ I LY + +S+EERHRHRYE+N +F+E E G+ FVGRD+ +
Sbjct: 467 ----------GTEWCAIKKLYGSAESVEERHRHRYEINPNFIERLEEHGLMFVGRDETNK 516
Query: 721 RMEILELNDHPYFVGVQYHPEYLSR 795
R EI E+ DHP+FV QYHPEY S+
Sbjct: 517 RCEIFEMKDHPFFVATQYHPEYTSK 541
>sp|O74638|PYRG_GIBZE CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 580
Score = 244 bits (624), Expect = 2e-64
Identities = 129/260 (49%), Positives = 172/260 (66%), Gaps = 2/260 (0%)
Frame = +1
Query: 22 WKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVNAEHLI- 198
WK+ D+ L VNI+LVGKYV+L+D+Y+SV+KAL H+A+ CN KL + V++EHL
Sbjct: 290 WKKTVVPDRH-LEPVNIILVGKYVSLDDSYLSVHKALEHSAMRCNRKLNLVSVDSEHLEP 348
Query: 199 ESNDKNI-EYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCLGMQC 375
E +K+ ++ EAW V A G+IVPGGFG RGI+G + K+ RE K+P LG+CLGMQ
Sbjct: 349 EMQEKDPRKFHEAWAHVVRAQGIIVPGGFGTRGIQGMVDVAKWARERKLPYLGICLGMQT 408
Query: 376 QVIEFARNVLGMCDAHSEEFDPDTKHKVVIEMPEFNPSQKGGTMRLGKRETFFHTKNQFL 555
VIE+ARNV+G+ A SEEF +H+VVI MPE + Q GGTMRLG R + F
Sbjct: 409 AVIEYARNVMGLKGATSEEFSATAEHRVVIFMPEGSKEQMGGTMRLGSRTSHF------- 461
Query: 556 NGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAEERMEIL 735
+ G+ S + LY V +EERHRHRYEVN D++E E G++ D R+E +
Sbjct: 462 ---KPGTEWSKLRGLYGGVDVVEERHRHRYEVNPDYIEDLEKAGLSLTSMDDQGVRVETI 518
Query: 736 ELNDHPYFVGVQYHPEYLSR 795
EL DHP+FVG+Q HPEY S+
Sbjct: 519 ELKDHPFFVGLQAHPEYKSK 538
>sp|Q751L7|PYRG_ASHGO CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 576
Score = 243 bits (620), Expect = 4e-64
Identities = 127/266 (47%), Positives = 169/266 (63%), Gaps = 5/266 (1%)
Frame = +1
Query: 13 LYKWKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVNAEH 192
L +W+ L +S V I LVGKY +L+D+Y+SV KAL H+++ C KL + V A
Sbjct: 287 LDRWRHLTTAIDESFEVVQIALVGKYTHLKDSYLSVIKALEHSSMRCKRKLEIVWVEASD 346
Query: 193 L---IESNDKNIEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCL 363
L + ++DK ++ +AWK +S + G++VPGGFG RG EG I A K+ RENK+P LGVCL
Sbjct: 347 LEPEMSASDKE-KFQQAWKSLSSSDGILVPGGFGTRGTEGMILAAKWARENKIPYLGVCL 405
Query: 364 GMQCQVIEFARNVLGMCDAHSEEFDPDTKH--KVVIEMPEFNPSQKGGTMRLGKRETFFH 537
G+Q IEFAR+VLG+ DA S EF P+ +VV+ MPE + GGTMRLG R T F
Sbjct: 406 GLQVATIEFARHVLGIADATSSEFYPEVAEDKQVVVYMPEIDKQNMGGTMRLGLRPTIFQ 465
Query: 538 TKNQFLNGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAE 717
+ S+I LY + S+EERHRHRYE+N ++ E G+ FVGRD+
Sbjct: 466 EDTDW----------SIIRKLYGSASSVEERHRHRYEINPKMVQKLEEHGLKFVGRDETG 515
Query: 718 ERMEILELNDHPYFVGVQYHPEYLSR 795
R EILEL DHPY+V QYHPEY+S+
Sbjct: 516 TRCEILELVDHPYYVATQYHPEYMSK 541
>sp|P28274|URA7_YEAST CTP synthase 1 (UTP--ammonia ligase 1) (CTP synthetase 1)
Length = 579
Score = 241 bits (615), Expect = 2e-63
Identities = 125/265 (47%), Positives = 167/265 (63%), Gaps = 4/265 (1%)
Frame = +1
Query: 13 LYKWKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVNAEH 192
L KWK +S+ V I LVGKY NL+D+Y+SV KAL H+++ C KL + V A
Sbjct: 287 LSKWKATTGNFDESMETVKIALVGKYTNLKDSYLSVIKALEHSSMKCRRKLDIKWVEATD 346
Query: 193 LI-ESNDKN-IEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCLG 366
L E+ + N ++ EAW VS A G+++PGGFG RG EG + A ++ REN +P LGVCLG
Sbjct: 347 LEPEAQESNKTKFHEAWNMVSTADGILIPGGFGVRGTEGMVLAARWARENHIPFLGVCLG 406
Query: 367 MQCQVIEFARNVLGMCDAHSEEFDP--DTKHKVVIEMPEFNPSQKGGTMRLGKRETFFHT 540
+Q IEF R+VLG D+HS EF P D K+ VV+ MPE + GG+MRLG R TFF
Sbjct: 407 LQIATIEFTRSVLGRKDSHSAEFYPDIDEKNHVVVFMPEIDKETMGGSMRLGLRPTFFQN 466
Query: 541 KNQFLNGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAEE 720
+ ++ S I LY +V + ERHRHRYE+N ++ EN G+ FVG+D +
Sbjct: 467 ETEW----------SQIKKLYGDVSEVHERHRHRYEINPKMVDELENNGLIFVGKDDTGK 516
Query: 721 RMEILELNDHPYFVGVQYHPEYLSR 795
R EILEL +HPY++ QYHPEY S+
Sbjct: 517 RCEILELKNHPYYIATQYHPEYTSK 541
>sp|Q8R720|PYRG_THETN CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 537
Score = 225 bits (573), Expect = 1e-58
Identities = 123/266 (46%), Positives = 165/266 (62%), Gaps = 1/266 (0%)
Frame = +1
Query: 4 KKDLYKWKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVN 183
+ DL +W+ +++K +V + LVGKYV+L DAYISV +AL HA ++ + + + VN
Sbjct: 271 QSDLKEWREYVEKEKNPEHQVEVALVGKYVDLHDAYISVVEALKHAGVYHKTAVNIRWVN 330
Query: 184 AEHLIESNDKNIEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCL 363
AE + NDK ++ L + A G++VPGGFG RGIEGKI AI++ RENK+P LG+CL
Sbjct: 331 AEKV---NDKTVDEL-----LKGADGILVPGGFGDRGIEGKIRAIQYARENKIPYLGLCL 382
Query: 364 GMQCQVIEFARNVLGMCDAHSEEFDPDTKHKVVIEMPEFNP-SQKGGTMRLGKRETFFHT 540
GMQC VIEFARNV G+ A+S EFDP+T H V+ MPE +KGGTMRLG
Sbjct: 383 GMQCAVIEFARNVAGLKGANSTEFDPNTPHPVIDLMPEQKDIDEKGGTMRLGVYPC---- 438
Query: 541 KNQFLNGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAEE 720
+ + G + Y + + ERHRHRYE N + EL +KG+ G E
Sbjct: 439 --KVIEGTKA--------YEVYKDELVYERHRHRYEFNNQYRELLTSKGLVISGLSPDER 488
Query: 721 RMEILELNDHPYFVGVQYHPEYLSRP 798
+EI+EL DHPYFV Q+HPE+ SRP
Sbjct: 489 LVEIIELKDHPYFVATQFHPEFKSRP 514
>sp|Q8TYT7|PYRG_METKA CTP synthase (UTP--ammonia ligase) (CTP synthetase)
Length = 535
Score = 217 bits (552), Expect = 3e-56
Identities = 121/264 (45%), Positives = 164/264 (62%), Gaps = 1/264 (0%)
Frame = +1
Query: 10 DLYKWKRLCDQDKKSLREVNIVLVGKYVNLEDAYISVYKALNHAALFCNSKLIMHQVNAE 189
D W + +++ E+ I +VGKYV+L DAYIS+ +AL HA + + V++E
Sbjct: 272 DYSDWLDFVTRIEEADDEIRIAVVGKYVDLPDAYISIREALVHAGAHVGVGVDVAWVDSE 331
Query: 190 HLIESNDKNIEYLEAWKKVSVAMGVIVPGGFGPRGIEGKIAAIKFCRENKVPILGVCLGM 369
L E+ D EAW++V A GV+VPGGFG RG+EGKI A+++ REN VP LG+CLG
Sbjct: 332 AL-EAGDS-----EAWEEVKDADGVLVPGGFGKRGVEGKIEAVRYARENDVPFLGICLGF 385
Query: 370 QCQVIEFARNVLGMCDAHSEEFDPDTKHKVVIEMPE-FNPSQKGGTMRLGKRETFFHTKN 546
Q V+E+AR+VLG+ DAHS EF+PDT H VV +PE +KGGTMRLG
Sbjct: 386 QLVVVEYARSVLGLEDAHSTEFNPDTDHPVVDLLPEQRGVKRKGGTMRLGAEPV------ 439
Query: 547 QFLNGAEIGSNHSVIHYLYNNVKSIEERHRHRYEVNTDFLELFENKGMNFVGRDKAEERM 726
+ S++ LY++ + + ERHRHRYEVN ++ E+ G+ F G + RM
Sbjct: 440 -------VLEEGSLLRRLYDDREIVLERHRHRYEVNPSYVRELEDHGLRFSGH-SPDGRM 491
Query: 727 EILELNDHPYFVGVQYHPEYLSRP 798
E LEL DHPYFVG Q+HPE+ SRP
Sbjct: 492 EALELPDHPYFVGTQFHPEFKSRP 515
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,382,122
Number of Sequences: 369166
Number of extensions: 2175276
Number of successful extensions: 7103
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6434
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6806
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)