Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01692
(562 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99728|BARD1_HUMAN BRCA1-associated RING domain protein ... 69 1e-11
sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H... 67 3e-11
sp|Q9QZH2|BARD1_RAT BRCA1-associated RING domain protein 1 ... 66 5e-11
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 66 7e-11
sp|Q9Z2F6|BCL3_MOUSE B-cell lymphoma 3-encoded protein homo... 65 9e-11
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 65 1e-10
sp|O70445|BARD1_MOUSE BRCA1-associated RING domain protein ... 65 1e-10
sp|Q8WXE0|CSKI2_HUMAN Caskin-2 64 2e-10
sp|Q8VHK1|CSKI2_MOUSE Caskin-2 64 2e-10
sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) ... 64 3e-10
>sp|Q99728|BARD1_HUMAN BRCA1-associated RING domain protein 1 (BARD-1)
Length = 777
Score = 68.6 bits (166), Expect = 1e-11
Identities = 36/96 (37%), Positives = 55/96 (57%)
Frame = +1
Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
++ G T LH + G++ + YL+ G+ D GW P+ AC + H+ V+ L+Q
Sbjct: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483
Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
K+ VN + +SPLH AA G++DIVKLL+ GA
Sbjct: 484 KALVNTTG-YQNDSPLHDAAKNGHVDIVKLLLSYGA 518
Score = 32.0 bits (71), Expect = 1.1
Identities = 14/36 (38%), Positives = 24/36 (66%)
Frame = +1
Query: 286 LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISY 393
LH + KNG+V+++ L+S GA +++ G RP+ Y
Sbjct: 498 LHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDY 533
>sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (Histone
H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic
histone-lysine N-methyltransferase 1) (Eu-HMTase1)
(G9a-like protein 1) (GLP1)
Length = 1267
Score = 67.0 bits (162), Expect = 3e-11
Identities = 43/137 (31%), Positives = 69/137 (50%), Gaps = 1/137 (0%)
Frame = +1
Query: 151 LINAAKSNKFEDLRKLFEXXXXXXXXXXXXENIDIDAKDSTGMTALHFSGKNGNVEMMVY 330
L+ AA++N E ++ L + +D KD+ G T LH + K G+ E++ Y
Sbjct: 779 LMEAAENNHLEAVKYLIKAGAL------------VDPKDAEGSTCLHLAAKKGHYEVVQY 826
Query: 331 LVSRGAC-IESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLMEENSPLHIAAGF 507
L+S G + D GW P+ +A H++ VK L+ S++N EEN LH AA
Sbjct: 827 LLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN-IRDNEENICLHWAAFS 885
Query: 508 GYIDIVKLLMENGAVVH 558
G +DI ++L+ +H
Sbjct: 886 GCVDIAEILLAAKCDLH 902
Score = 51.2 bits (121), Expect = 2e-06
Identities = 30/87 (34%), Positives = 52/87 (59%)
Frame = +1
Query: 286 LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFS 465
LH + + G+V++ LV GA I++ ++ P+ A NNH+ AVK LI+ + V+
Sbjct: 746 LHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD 805
Query: 466 LMEENSPLHIAAGFGYIDIVKLLMENG 546
E ++ LH+AA G+ ++V+ L+ NG
Sbjct: 806 -AEGSTCLHLAAKKGHYEVVQYLLSNG 831
Score = 29.6 bits (65), Expect = 5.3
Identities = 13/31 (41%), Positives = 19/31 (61%)
Frame = +1
Query: 457 KFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
K + SPLH AA G++DI +L++ GA
Sbjct: 736 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGA 766
>sp|Q9QZH2|BARD1_RAT BRCA1-associated RING domain protein 1 (BARD-1)
Length = 768
Score = 66.2 bits (160), Expect = 5e-11
Identities = 35/96 (36%), Positives = 54/96 (56%)
Frame = +1
Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
++ G T LH + G++ + YL+ G D GW P+ AC++ H+ V+ L+Q
Sbjct: 414 RNHRGETLLHIASIKGDISSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKIVELLLQH 473
Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+ VN +SPLH AA G+IDIVK+L+ +GA
Sbjct: 474 NALVNTTG-YHNDSPLHDAAKNGHIDIVKVLLSHGA 508
Score = 35.8 bits (81), Expect = 0.074
Identities = 18/60 (30%), Positives = 34/60 (56%)
Frame = +1
Query: 286 LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFS 465
LH + KNG+++++ L+S GA +++ G RP+ Y A N +++L+ + FS
Sbjct: 488 LHDAAKNGHIDIVKVLLSHGASRNAVNIFGERPVDYTDAEN----IRSLLLLPEKTDSFS 543
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 65.9 bits (159), Expect = 7e-11
Identities = 32/99 (32%), Positives = 60/99 (60%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
I+ K +T LH + +NG+V + L+ GA I++ +NG PI A +H++ V+ L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+Q+ + ++ +L + +PLH+AA G+ + K+L++ GA
Sbjct: 325 LQYDAEIDDITL-DHLTPLHVAAHCGHHRVAKVLLDKGA 362
Score = 59.7 bits (143), Expect = 5e-09
Identities = 32/95 (33%), Positives = 56/95 (58%)
Frame = +1
Query: 274 GMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNV 453
G T LH + K +V +M L+ GA I+++ ++G P+ A H+ VK L+Q ++
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 454 NKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
N ++ E +PLH+AA G+ ++ K L++N A V+
Sbjct: 431 NVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVN 464
Score = 59.7 bits (143), Expect = 5e-09
Identities = 33/95 (34%), Positives = 56/95 (58%)
Frame = +1
Query: 265 DSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWK 444
+ +G+T LH + G+V + L+ G +++ + G+ P+ A +I VK L+Q +
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724
Query: 445 SNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
++VN + + SPLH AA G+ DIV LL++NGA
Sbjct: 725 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 58.9 bits (141), Expect = 8e-09
Identities = 31/101 (30%), Positives = 58/101 (57%)
Frame = +1
Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
+DI+ + G+ LH + K G+V+M+V L+ + +E+ + G + A V+
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 427 TLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
L+ + +NVN S + +PL++AA ++++VK L+ENGA
Sbjct: 96 ELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGA 135
Score = 54.3 bits (129), Expect = 2e-07
Identities = 29/98 (29%), Positives = 54/98 (55%)
Frame = +1
Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
+A G+T LH + + N++++ L+ RG S NG+ P+ A N + ++L+
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
Q+ + N S ++ +PLH+AA G+ ++V LL+ A
Sbjct: 623 QYGGSANAES-VQGVTPLHLAAQEGHAEMVALLLSKQA 659
Score = 53.5 bits (127), Expect = 3e-07
Identities = 29/100 (29%), Positives = 53/100 (53%)
Frame = +1
Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
D TG T LH + N+ + L++RGA + QNG P+ A ++ V+ L+
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
+ + + +E +PLH AA G++ I ++L+++GA +
Sbjct: 260 DRGAQI-ETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Score = 52.8 bits (125), Expect = 6e-07
Identities = 30/101 (29%), Positives = 57/101 (56%), Gaps = 1/101 (0%)
Frame = +1
Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
+ID +T LH + G+ + L+ +GA S NG+ P+ AC NH+ ++
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389
Query: 430 LIQWKSNVNKFSLMEEN-SPLHIAAGFGYIDIVKLLMENGA 549
L++ ++++ ++ E +PLH+A+ G++ IVK L++ GA
Sbjct: 390 LLKTGASID--AVTESGLTPLHVASFMGHLPIVKNLLQRGA 428
Score = 48.5 bits (114), Expect = 1e-05
Identities = 28/90 (31%), Positives = 48/90 (53%)
Frame = +1
Query: 280 TALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNK 459
T LH + + G+ E+ YL+ A + + ++ P+ A H N VK L++ +N N
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN- 497
Query: 460 FSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+ ++PLHIAA G+++ V L+E A
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEA 527
Score = 47.8 bits (112), Expect = 2e-05
Identities = 26/94 (27%), Positives = 49/94 (52%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
+DA G T LH + GN++++ +L+ A + + + G+ P+ A H + V L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLL 534
++ ++ N+ S + +PL IA GYI + +L
Sbjct: 754 LKNGASPNEVS-SDGTTPLAIAKRLGYISVTDVL 786
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/105 (25%), Positives = 51/105 (48%)
Frame = +1
Query: 244 NIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAV 423
N + + + G T LH + + G+VE ++ L+ + A + + G+ P+ A +
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 424 KTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
+ L++ ++ N +PLH+A +DIVKLL+ G H
Sbjct: 553 ELLLERDAHPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/131 (21%), Positives = 60/131 (45%), Gaps = 28/131 (21%)
Frame = +1
Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
+++A+ G T L+ + + ++E++ +L+ GA ++G+ P++ A H N V
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162
Query: 430 LIQW----------------KSNVNKFSLMEEN------------SPLHIAAGFGYIDIV 525
LI + + +++ +N +PLHIAA + +++
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222
Query: 526 KLLMENGAVVH 558
+LL+ GA V+
Sbjct: 223 QLLLNRGASVN 233
Score = 39.7 bits (91), Expect = 0.005
Identities = 25/99 (25%), Positives = 51/99 (51%)
Frame = +1
Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
+++ T+ + ++GN++ + + G I + +QNG + A H+ V L+
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH- 66
Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
K + + + + N+ LHIAA G ++V+ L+ GA V+
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
>sp|Q9Z2F6|BCL3_MOUSE B-cell lymphoma 3-encoded protein homolog (Bcl-3 protein)
Length = 440
Score = 65.5 bits (158), Expect = 9e-11
Identities = 35/103 (33%), Positives = 65/103 (63%), Gaps = 1/103 (0%)
Frame = +1
Query: 244 NIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESID-QNGWRPISYACANNHINA 420
++D++ ++ G+TALH + G E ++ L+ RGA I+++D ++G P+ +A NN +N
Sbjct: 219 SVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLIHAVENNSLNM 278
Query: 421 VKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
V+ L+ +NVN + +S LH A+G G + +V+ L+ +GA
Sbjct: 279 VQLLLLHGANVNA-QMYSGSSALHSASGRGLLPLVRTLVRSGA 320
Score = 37.4 bits (85), Expect = 0.026
Identities = 26/103 (25%), Positives = 51/103 (49%), Gaps = 3/103 (2%)
Frame = +1
Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
++D ++ T LH + +M+ LV+ GA ++D++G I AC + + ++
Sbjct: 151 EVDVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPMALDRHGQTAIHLACEHRSPSCLQA 210
Query: 430 LIQWKSNVN---KFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
L+ ++ + + E + LH+A G + V LL+E GA
Sbjct: 211 LLDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGA 253
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 65.1 bits (157), Expect = 1e-10
Identities = 31/99 (31%), Positives = 60/99 (60%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
I+ + +T LH + +NG+V + L+ GA I++ +NG PI A +H++ V+ L
Sbjct: 261 IETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 320
Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+Q+ + ++ +L + +PLH+AA G+ + K+L++ GA
Sbjct: 321 LQYNAEIDDITL-DHLTPLHVAAHCGHHRVAKVLLDKGA 358
Score = 58.9 bits (141), Expect = 8e-09
Identities = 31/101 (30%), Positives = 58/101 (57%)
Frame = +1
Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
+DI+ + G+ LH + K G+V+M+V L+ + +E+ + G + A V+
Sbjct: 32 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 91
Query: 427 TLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
L+ + +NVN S + +PL++AA ++++VK L+ENGA
Sbjct: 92 ELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGA 131
Score = 58.9 bits (141), Expect = 8e-09
Identities = 33/95 (34%), Positives = 56/95 (58%)
Frame = +1
Query: 265 DSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWK 444
+ +G+T LH + G+V + L+ G +++ + G+ P+ A +I VK L+Q +
Sbjct: 661 NKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 720
Query: 445 SNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
++VN + + SPLH AA G+ DIV LL++NGA
Sbjct: 721 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGA 754
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/99 (34%), Positives = 52/99 (52%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
IDA +G+T LH + G++ ++ L+ RGA + P+ A H K L
Sbjct: 393 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 452
Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+Q K+ N ++ +PLH AA G+ +VKLL+ENGA
Sbjct: 453 LQNKAKANA-KAKDDQTPLHCAARIGHTGMVKLLLENGA 490
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/103 (31%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Frame = +1
Query: 244 NIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAV 423
N +ID +T LH + G+ + L+ +GA S NG+ P+ AC NHI +
Sbjct: 324 NAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVM 383
Query: 424 KTLIQWKSNVNKFSLMEEN-SPLHIAAGFGYIDIVKLLMENGA 549
+ L++ ++++ ++ E +PLH+A+ G++ IVK L++ GA
Sbjct: 384 ELLLKTGASID--AVTESGLTPLHVASFMGHLPIVKNLLQRGA 424
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/98 (30%), Positives = 54/98 (55%)
Frame = +1
Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
+A G+T LH + + N++++ L+ RG S NG+ P+ A N I ++L+
Sbjct: 559 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLL 618
Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
Q+ + N S ++ +PLH+AA G+ ++V LL+ A
Sbjct: 619 QYGGSANAES-VQGVTPLHLAAQEGHTEMVALLLSKQA 655
Score = 53.1 bits (126), Expect = 5e-07
Identities = 29/100 (29%), Positives = 53/100 (53%)
Frame = +1
Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
D TG T LH + N+ + L++RGA + QNG P+ A ++ V+ L+
Sbjct: 196 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 255
Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
+ + + +E +PLH AA G++ I ++L+++GA +
Sbjct: 256 DRGAQI-ETRTKDELTPLHCAARNGHVRISEILLDHGAPI 294
Score = 49.3 bits (116), Expect = 6e-06
Identities = 29/106 (27%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
Frame = +1
Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
+ +DA G T LH + GN++++ +L+ A + + + G+ P+ A H + V
Sbjct: 688 VTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 747
Query: 427 TLIQWKSNVNKFSLMEENSPLHIAAGFGYI---DIVKLLMENGAVV 555
L++ ++ N+ S +PL IA GYI D++K++ + +VV
Sbjct: 748 LLLKNGASPNEVS-SNGTTPLAIAKRLGYISVTDVLKVVTDETSVV 792
Score = 44.3 bits (103), Expect = 2e-04
Identities = 25/97 (25%), Positives = 47/97 (48%)
Frame = +1
Query: 268 STGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKS 447
+ G T LH + + G+V+ + L+ + A + + G+ P+ A + + L++ +
Sbjct: 497 TAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDA 556
Query: 448 NVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
+ N +PLH+A +DIVKLL+ G H
Sbjct: 557 HPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 592
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/131 (21%), Positives = 60/131 (45%), Gaps = 28/131 (21%)
Frame = +1
Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
+++A+ G T L+ + + ++E++ +L+ GA ++G+ P++ A H N V
Sbjct: 99 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 158
Query: 430 LIQW----------------KSNVNKFSLMEEN------------SPLHIAAGFGYIDIV 525
LI + + +++ +N +PLHIAA + +++
Sbjct: 159 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 218
Query: 526 KLLMENGAVVH 558
+LL+ GA V+
Sbjct: 219 QLLLNRGASVN 229
Score = 38.5 bits (88), Expect = 0.011
Identities = 24/88 (27%), Positives = 46/88 (52%)
Frame = +1
Query: 295 SGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLME 474
+ ++GN++ + + G I + +QNG + A H+ V L+ K + + + +
Sbjct: 15 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH-KEIILETTTKK 73
Query: 475 ENSPLHIAAGFGYIDIVKLLMENGAVVH 558
N+ LHIAA G ++V+ L+ GA V+
Sbjct: 74 GNTALHIAALAGQDEVVRELVNYGANVN 101
>sp|O70445|BARD1_MOUSE BRCA1-associated RING domain protein 1 (BARD-1)
Length = 765
Score = 65.1 bits (157), Expect = 1e-10
Identities = 34/96 (35%), Positives = 54/96 (56%)
Frame = +1
Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
++ G T LH + G++ + YL+ G D GW P+ AC++ H+ V+ L+Q
Sbjct: 412 RNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKVVELLLQH 471
Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+ VN + +SPLH A G+IDIVK+L+ +GA
Sbjct: 472 NALVNTPG-YQNDSPLHDAVKSGHIDIVKVLLSHGA 506
Score = 29.3 bits (64), Expect = 7.0
Identities = 13/41 (31%), Positives = 25/41 (60%)
Frame = +1
Query: 286 LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANN 408
LH + K+G+++++ L+S GA +++ G RP+ Y N
Sbjct: 486 LHDAVKSGHIDIVKVLLSHGASRNAVNIFGVRPVDYTDNEN 526
>sp|Q8WXE0|CSKI2_HUMAN Caskin-2
Length = 1202
Score = 64.3 bits (155), Expect = 2e-10
Identities = 36/136 (26%), Positives = 74/136 (54%), Gaps = 1/136 (0%)
Frame = +1
Query: 139 KEIKLINAAKSNKFEDLRKLF-EXXXXXXXXXXXXENIDIDAKDSTGMTALHFSGKNGNV 315
+E LI A K+ ++KL + + ++++ +D+ G +ALH + G++
Sbjct: 3 REQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSL 62
Query: 316 EMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLMEENSPLHI 495
E++ L+ A ++ D NG RP+ YA + V+ L++ + VN SL + PLH+
Sbjct: 63 ELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASL-DGQIPLHL 121
Query: 496 AAGFGYIDIVKLLMEN 543
AA +G+ ++ ++L+++
Sbjct: 122 AAQYGHYEVSEMLLQH 137
Score = 51.6 bits (122), Expect = 1e-06
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 3/100 (3%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
+D KDS GM LH++ G +E + L+ A + + +G P+ A H + L
Sbjct: 75 VDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEML 134
Query: 433 IQWKSN---VNKFSLMEENSPLHIAAGFGYIDIVKLLMEN 543
+Q +SN VNK + +PL +A FG + + +LL+ +
Sbjct: 135 LQHQSNPCLVNK----AKKTPLDLACEFGRLKVAQLLLNS 170
>sp|Q8VHK1|CSKI2_MOUSE Caskin-2
Length = 1201
Score = 64.3 bits (155), Expect = 2e-10
Identities = 30/101 (29%), Positives = 62/101 (61%)
Frame = +1
Query: 241 ENIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINA 420
+ ++I+ +D+ G +ALH + G++E++ L+ A ++ D NG RP+ YA +
Sbjct: 38 KRLNINYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97
Query: 421 VKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMEN 543
V+ L++ + VN SL + PLH+AA +G+ ++ ++L+++
Sbjct: 98 VRLLLRASAAVNAASL-DGQIPLHLAAQYGHYEVSEMLLQH 137
Score = 52.0 bits (123), Expect = 1e-06
Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 3/100 (3%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
+D KDS GM LH++ G +E + L+ A + + +G P+ A H + L
Sbjct: 75 VDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEML 134
Query: 433 IQWKSN---VNKFSLMEENSPLHIAAGFGYIDIVKLLMEN 543
+Q +SN VNK + +PL +A FG + + +LL+ +
Sbjct: 135 LQHQSNPCLVNKL----KKTPLDLACEFGRLKVAQLLLNS 170
>sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
Length = 3924
Score = 63.5 bits (153), Expect = 3e-10
Identities = 35/101 (34%), Positives = 58/101 (57%)
Frame = +1
Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
IDI+ + G+ ALH + K G+V ++ L+ RG+ ++S + G + A VK
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
Query: 427 TLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
L++ +N+N S +PL++AA +ID+VK L+ENGA
Sbjct: 115 VLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGA 154
Score = 62.8 bits (151), Expect = 6e-10
Identities = 34/99 (34%), Positives = 60/99 (60%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
IDAK G+T LH + ++G+ +++ L+ RGA + + +NG P+ A +H+ VK L
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+Q K+ V+ +L + + LH+AA G+ + KLL++ A
Sbjct: 352 LQHKAPVDDVTL-DYLTALHVAAHCGHYRVTKLLLDKRA 389
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/100 (34%), Positives = 59/100 (59%)
Frame = +1
Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
+A+ G T LH + K +++M LV GA I++I ++G PI A H+N V L+
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
Q ++ + ++ E + LH+AA G +++V+ L+ NGA+V
Sbjct: 452 QNGASPDVTNIRGETA-LHMAARAGQVEVVRCLLRNGALV 490
Score = 58.5 bits (140), Expect = 1e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
+D+ G TALH + G E++ LV GA I + QNG+ P+ A NHI+ VK L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 433 IQWKSNVNKFSLMEEN-SPLHIAAGFGYIDIVKLLMEN 543
++ + N+ + E+ +PL +A G+ V +L+EN
Sbjct: 150 LE--NGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
Score = 58.2 bits (139), Expect = 1e-08
Identities = 29/101 (28%), Positives = 54/101 (53%)
Frame = +1
Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
D+ G+T LH + N ++ + L+ +GA + +NG+ P+ A N + TL+
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
+ + N + +PLH+A+ G+ D+V LL++ GA +H
Sbjct: 650 NYGAETN-IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689
Score = 57.8 bits (138), Expect = 2e-08
Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 6/108 (5%)
Frame = +1
Query: 244 NIDIDAK------DSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACAN 405
N D+ +K +G T LH + GNV + L++RGA ++ +NG P+ A
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276
Query: 406 NHINAVKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
+ N VK L+ ++ + +PLH AA G+ +V+LL+E GA
Sbjct: 277 GNTNMVKLLLDRGGQIDA-KTRDGLTPLHCAARSGHDQVVELLLERGA 323
Score = 53.5 bits (127), Expect = 3e-07
Identities = 28/92 (30%), Positives = 55/92 (59%), Gaps = 1/92 (1%)
Frame = +1
Query: 277 MTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVN 456
+TALH + G+ + L+ + A + NG+ P+ AC N I ++ L+++ +++
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 457 KFSLMEEN-SPLHIAAGFGYIDIVKLLMENGA 549
++ E +P+H+AA G+++IV LL++NGA
Sbjct: 426 --AITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Score = 50.4 bits (119), Expect = 3e-06
Identities = 30/95 (31%), Positives = 48/95 (50%)
Frame = +1
Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
D DA G T L + GNV+M+ +L+ +GA + + +NG+ P+ A H + +
Sbjct: 720 DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 779
Query: 430 LIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLL 534
L+Q + N + N+ L IA GYI +V L
Sbjct: 780 LLQHGAKPNA-TTANGNTALAIAKRLGYISVVDTL 813
Score = 49.7 bits (117), Expect = 5e-06
Identities = 32/104 (30%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
+D G+T LH + K GN M+ L+ RG I++ ++G P+ A + H V+ L
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Query: 433 IQWKSNV---NKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
++ + + K L SPLH+AA +++ VK L+++ A V
Sbjct: 319 LERGAPLLARTKNGL----SPLHMAAQGDHVECVKHLLQHKAPV 358
Score = 49.3 bits (116), Expect = 6e-06
Identities = 28/100 (28%), Positives = 52/100 (52%)
Frame = +1
Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
+I +G+T+LH + + V + L GA ++ + G+ P+ AC ++ V
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746
Query: 430 LIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
L++ +NVN +PLH AA G+ I+ +L+++GA
Sbjct: 747 LLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGA 785
Score = 48.5 bits (114), Expect = 1e-05
Identities = 24/99 (24%), Positives = 50/99 (50%)
Frame = +1
Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
+DA+ T LH + + G E++ L+ A ++ NG+ P+ + ++ L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
++ + + + +PLH+AA +G +D+ KLL++ A
Sbjct: 550 LE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Score = 45.4 bits (106), Expect = 9e-05
Identities = 25/88 (28%), Positives = 50/88 (56%)
Frame = +1
Query: 295 SGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLME 474
+ + GN++ +V + G I + +QNG + A H+ V+ L+ S+V+ + +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS-ATKK 96
Query: 475 ENSPLHIAAGFGYIDIVKLLMENGAVVH 558
N+ LHIA+ G ++VK+L++ GA ++
Sbjct: 97 GNTALHIASLAGQAEVVKVLVKEGANIN 124
Score = 42.4 bits (98), Expect = 8e-04
Identities = 23/95 (24%), Positives = 50/95 (52%)
Frame = +1
Query: 274 GMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNV 453
G+T LH + + G+ +M+ L+ +GA I ++G + A + +N L + ++
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 454 NKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
+ + + +PL +A +G + +V L++ GA V+
Sbjct: 722 DAHTKL-GYTPLIVACHYGNVKMVNFLLKQGANVN 755
Score = 37.4 bits (85), Expect = 0.026
Identities = 25/111 (22%), Positives = 50/111 (45%), Gaps = 8/111 (7%)
Frame = +1
Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYL--------VSRGACIESIDQNGWRPISYACA 402
++ D K + ALH + + + + L V + ++G+ P+ A
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242
Query: 403 NNHINAVKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
++N V TL+ + F+ +PLH+A+ G ++VKLL++ G +
Sbjct: 243 YGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,570,921
Number of Sequences: 369166
Number of extensions: 751569
Number of successful extensions: 2802
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1774
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2508
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4029688280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)