Planaria EST Database


DrC_01692

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01692
         (562 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q99728|BARD1_HUMAN  BRCA1-associated RING domain protein ...    69   1e-11
sp|Q9H9B1|EHMT1_HUMAN  Histone-lysine N-methyltransferase, H...    67   3e-11
sp|Q9QZH2|BARD1_RAT  BRCA1-associated RING domain protein 1 ...    66   5e-11
sp|P16157|ANK1_HUMAN  Ankyrin-1 (Erythrocyte ankyrin) (Ankyr...    66   7e-11
sp|Q9Z2F6|BCL3_MOUSE  B-cell lymphoma 3-encoded protein homo...    65   9e-11
sp|Q02357|ANK1_MOUSE  Ankyrin-1 (Erythrocyte ankyrin)              65   1e-10
sp|O70445|BARD1_MOUSE  BRCA1-associated RING domain protein ...    65   1e-10
sp|Q8WXE0|CSKI2_HUMAN  Caskin-2                                    64   2e-10
sp|Q8VHK1|CSKI2_MOUSE  Caskin-2                                    64   2e-10
sp|Q01484|ANK2_HUMAN  Ankyrin-2 (Brain ankyrin) (Ankyrin B) ...    64   3e-10
>sp|Q99728|BARD1_HUMAN BRCA1-associated RING domain protein 1 (BARD-1)
          Length = 777

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 36/96 (37%), Positives = 55/96 (57%)
 Frame = +1

Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
           ++  G T LH +   G++  + YL+  G+     D  GW P+  AC + H+  V+ L+Q 
Sbjct: 424 RNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQH 483

Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           K+ VN     + +SPLH AA  G++DIVKLL+  GA
Sbjct: 484 KALVNTTG-YQNDSPLHDAAKNGHVDIVKLLLSYGA 518

 Score = 32.0 bits (71), Expect = 1.1
 Identities = 14/36 (38%), Positives = 24/36 (66%)
 Frame = +1

Query: 286 LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISY 393
           LH + KNG+V+++  L+S GA   +++  G RP+ Y
Sbjct: 498 LHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDY 533
>sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (Histone
            H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic
            histone-lysine N-methyltransferase 1) (Eu-HMTase1)
            (G9a-like protein 1) (GLP1)
          Length = 1267

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 43/137 (31%), Positives = 69/137 (50%), Gaps = 1/137 (0%)
 Frame = +1

Query: 151  LINAAKSNKFEDLRKLFEXXXXXXXXXXXXENIDIDAKDSTGMTALHFSGKNGNVEMMVY 330
            L+ AA++N  E ++ L +                +D KD+ G T LH + K G+ E++ Y
Sbjct: 779  LMEAAENNHLEAVKYLIKAGAL------------VDPKDAEGSTCLHLAAKKGHYEVVQY 826

Query: 331  LVSRGAC-IESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLMEENSPLHIAAGF 507
            L+S G   +   D  GW P+ +A    H++ VK L+   S++N     EEN  LH AA  
Sbjct: 827  LLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDIN-IRDNEENICLHWAAFS 885

Query: 508  GYIDIVKLLMENGAVVH 558
            G +DI ++L+     +H
Sbjct: 886  GCVDIAEILLAAKCDLH 902

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 30/87 (34%), Positives = 52/87 (59%)
 Frame = +1

Query: 286  LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFS 465
            LH + + G+V++   LV  GA I++  ++   P+  A  NNH+ AVK LI+  + V+   
Sbjct: 746  LHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKD 805

Query: 466  LMEENSPLHIAAGFGYIDIVKLLMENG 546
              E ++ LH+AA  G+ ++V+ L+ NG
Sbjct: 806  -AEGSTCLHLAAKKGHYEVVQYLLSNG 831

 Score = 29.6 bits (65), Expect = 5.3
 Identities = 13/31 (41%), Positives = 19/31 (61%)
 Frame = +1

Query: 457 KFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           K     + SPLH AA  G++DI  +L++ GA
Sbjct: 736 KMEHQNKRSPLHAAAEAGHVDICHMLVQAGA 766
>sp|Q9QZH2|BARD1_RAT BRCA1-associated RING domain protein 1 (BARD-1)
          Length = 768

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 35/96 (36%), Positives = 54/96 (56%)
 Frame = +1

Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
           ++  G T LH +   G++  + YL+  G      D  GW P+  AC++ H+  V+ L+Q 
Sbjct: 414 RNHRGETLLHIASIKGDISSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKIVELLLQH 473

Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
            + VN       +SPLH AA  G+IDIVK+L+ +GA
Sbjct: 474 NALVNTTG-YHNDSPLHDAAKNGHIDIVKVLLSHGA 508

 Score = 35.8 bits (81), Expect = 0.074
 Identities = 18/60 (30%), Positives = 34/60 (56%)
 Frame = +1

Query: 286 LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFS 465
           LH + KNG+++++  L+S GA   +++  G RP+ Y  A N    +++L+      + FS
Sbjct: 488 LHDAAKNGHIDIVKVLLSHGASRNAVNIFGERPVDYTDAEN----IRSLLLLPEKTDSFS 543
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
          Length = 1881

 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 32/99 (32%), Positives = 60/99 (60%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           I+ K    +T LH + +NG+V +   L+  GA I++  +NG  PI  A   +H++ V+ L
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           +Q+ + ++  +L +  +PLH+AA  G+  + K+L++ GA
Sbjct: 325 LQYDAEIDDITL-DHLTPLHVAAHCGHHRVAKVLLDKGA 362

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 32/95 (33%), Positives = 56/95 (58%)
 Frame = +1

Query: 274 GMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNV 453
           G T LH + K  +V +M  L+  GA I+++ ++G  P+  A    H+  VK L+Q  ++ 
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 454 NKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
           N  ++  E +PLH+AA  G+ ++ K L++N A V+
Sbjct: 431 NVSNVKVE-TPLHMAARAGHTEVAKYLLQNKAKVN 464

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 33/95 (34%), Positives = 56/95 (58%)
 Frame = +1

Query: 265 DSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWK 444
           + +G+T LH   + G+V +   L+  G  +++  + G+ P+  A    +I  VK L+Q +
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 724

Query: 445 SNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           ++VN  + +   SPLH AA  G+ DIV LL++NGA
Sbjct: 725 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGA 758

 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 31/101 (30%), Positives = 58/101 (57%)
 Frame = +1

Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
           +DI+  +  G+  LH + K G+V+M+V L+ +   +E+  + G   +  A        V+
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95

Query: 427 TLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
            L+ + +NVN  S  +  +PL++AA   ++++VK L+ENGA
Sbjct: 96  ELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGA 135

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 29/98 (29%), Positives = 54/98 (55%)
 Frame = +1

Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
           +A    G+T LH +  + N++++  L+ RG    S   NG+ P+  A   N +   ++L+
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622

Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           Q+  + N  S ++  +PLH+AA  G+ ++V LL+   A
Sbjct: 623 QYGGSANAES-VQGVTPLHLAAQEGHAEMVALLLSKQA 659

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 29/100 (29%), Positives = 53/100 (53%)
 Frame = +1

Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
           D    TG T LH +    N+ +   L++RGA +    QNG  P+  A    ++  V+ L+
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259

Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
              + + +    +E +PLH AA  G++ I ++L+++GA +
Sbjct: 260 DRGAQI-ETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 30/101 (29%), Positives = 57/101 (56%), Gaps = 1/101 (0%)
 Frame = +1

Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
           +ID      +T LH +   G+  +   L+ +GA   S   NG+ P+  AC  NH+  ++ 
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMEL 389

Query: 430 LIQWKSNVNKFSLMEEN-SPLHIAAGFGYIDIVKLLMENGA 549
           L++  ++++  ++ E   +PLH+A+  G++ IVK L++ GA
Sbjct: 390 LLKTGASID--AVTESGLTPLHVASFMGHLPIVKNLLQRGA 428

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 28/90 (31%), Positives = 48/90 (53%)
 Frame = +1

Query: 280 TALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNK 459
           T LH + + G+ E+  YL+   A + +  ++   P+  A    H N VK L++  +N N 
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN- 497

Query: 460 FSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
            +    ++PLHIAA  G+++ V  L+E  A
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEA 527

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 26/94 (27%), Positives = 49/94 (52%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           +DA    G T LH +   GN++++ +L+   A + +  + G+ P+  A    H + V  L
Sbjct: 694 VDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753

Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLL 534
           ++  ++ N+ S  +  +PL IA   GYI +  +L
Sbjct: 754 LKNGASPNEVS-SDGTTPLAIAKRLGYISVTDVL 786

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 27/105 (25%), Positives = 51/105 (48%)
 Frame = +1

Query: 244 NIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAV 423
           N + +   + G T LH + + G+VE ++ L+ + A    + + G+ P+  A     +   
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552

Query: 424 KTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
           + L++  ++ N        +PLH+A     +DIVKLL+  G   H
Sbjct: 553 ELLLERDAHPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 28/131 (21%), Positives = 60/131 (45%), Gaps = 28/131 (21%)
 Frame = +1

Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
           +++A+   G T L+ + +  ++E++ +L+  GA      ++G+ P++ A    H N V  
Sbjct: 103 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 162

Query: 430 LIQW----------------KSNVNKFSLMEEN------------SPLHIAAGFGYIDIV 525
           LI +                  +    +++ +N            +PLHIAA +  +++ 
Sbjct: 163 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 222

Query: 526 KLLMENGAVVH 558
           +LL+  GA V+
Sbjct: 223 QLLLNRGASVN 233

 Score = 39.7 bits (91), Expect = 0.005
 Identities = 25/99 (25%), Positives = 51/99 (51%)
 Frame = +1

Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
           +++   T+   + ++GN++  +  +  G  I + +QNG   +  A    H+  V  L+  
Sbjct: 8   READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH- 66

Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
           K  + + +  + N+ LHIAA  G  ++V+ L+  GA V+
Sbjct: 67  KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 105
>sp|Q9Z2F6|BCL3_MOUSE B-cell lymphoma 3-encoded protein homolog (Bcl-3 protein)
          Length = 440

 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 35/103 (33%), Positives = 65/103 (63%), Gaps = 1/103 (0%)
 Frame = +1

Query: 244 NIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESID-QNGWRPISYACANNHINA 420
           ++D++ ++  G+TALH +   G  E ++ L+ RGA I+++D ++G  P+ +A  NN +N 
Sbjct: 219 SVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGADIDAVDIKSGRSPLIHAVENNSLNM 278

Query: 421 VKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           V+ L+   +NVN   +   +S LH A+G G + +V+ L+ +GA
Sbjct: 279 VQLLLLHGANVNA-QMYSGSSALHSASGRGLLPLVRTLVRSGA 320

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 26/103 (25%), Positives = 51/103 (49%), Gaps = 3/103 (2%)
 Frame = +1

Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
           ++D  ++   T LH +      +M+  LV+ GA   ++D++G   I  AC +   + ++ 
Sbjct: 151 EVDVHNNLRQTPLHLAVITTLPDMVRLLVTAGASPMALDRHGQTAIHLACEHRSPSCLQA 210

Query: 430 LIQWKSNVN---KFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           L+   ++ +   +    E  + LH+A   G  + V LL+E GA
Sbjct: 211 LLDSATSGSVDLEVRNYEGLTALHVAVNTGCQEAVLLLLERGA 253
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
          Length = 1862

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 31/99 (31%), Positives = 60/99 (60%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           I+ +    +T LH + +NG+V +   L+  GA I++  +NG  PI  A   +H++ V+ L
Sbjct: 261 IETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 320

Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           +Q+ + ++  +L +  +PLH+AA  G+  + K+L++ GA
Sbjct: 321 LQYNAEIDDITL-DHLTPLHVAAHCGHHRVAKVLLDKGA 358

 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 31/101 (30%), Positives = 58/101 (57%)
 Frame = +1

Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
           +DI+  +  G+  LH + K G+V+M+V L+ +   +E+  + G   +  A        V+
Sbjct: 32  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 91

Query: 427 TLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
            L+ + +NVN  S  +  +PL++AA   ++++VK L+ENGA
Sbjct: 92  ELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGA 131

 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 33/95 (34%), Positives = 56/95 (58%)
 Frame = +1

Query: 265 DSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWK 444
           + +G+T LH   + G+V +   L+  G  +++  + G+ P+  A    +I  VK L+Q +
Sbjct: 661 NKSGLTPLHLVSQEGHVLVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQ 720

Query: 445 SNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           ++VN  + +   SPLH AA  G+ DIV LL++NGA
Sbjct: 721 ADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNGA 754

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 34/99 (34%), Positives = 52/99 (52%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           IDA   +G+T LH +   G++ ++  L+ RGA     +     P+  A    H    K L
Sbjct: 393 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 452

Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           +Q K+  N     ++ +PLH AA  G+  +VKLL+ENGA
Sbjct: 453 LQNKAKANA-KAKDDQTPLHCAARIGHTGMVKLLLENGA 490

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 32/103 (31%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
 Frame = +1

Query: 244 NIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAV 423
           N +ID      +T LH +   G+  +   L+ +GA   S   NG+ P+  AC  NHI  +
Sbjct: 324 NAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVM 383

Query: 424 KTLIQWKSNVNKFSLMEEN-SPLHIAAGFGYIDIVKLLMENGA 549
           + L++  ++++  ++ E   +PLH+A+  G++ IVK L++ GA
Sbjct: 384 ELLLKTGASID--AVTESGLTPLHVASFMGHLPIVKNLLQRGA 424

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/98 (30%), Positives = 54/98 (55%)
 Frame = +1

Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
           +A    G+T LH +  + N++++  L+ RG    S   NG+ P+  A   N I   ++L+
Sbjct: 559 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLL 618

Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           Q+  + N  S ++  +PLH+AA  G+ ++V LL+   A
Sbjct: 619 QYGGSANAES-VQGVTPLHLAAQEGHTEMVALLLSKQA 655

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 29/100 (29%), Positives = 53/100 (53%)
 Frame = +1

Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
           D    TG T LH +    N+ +   L++RGA +    QNG  P+  A    ++  V+ L+
Sbjct: 196 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 255

Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
              + + +    +E +PLH AA  G++ I ++L+++GA +
Sbjct: 256 DRGAQI-ETRTKDELTPLHCAARNGHVRISEILLDHGAPI 294

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 29/106 (27%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
 Frame = +1

Query: 247  IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
            + +DA    G T LH +   GN++++ +L+   A + +  + G+ P+  A    H + V 
Sbjct: 688  VTVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 747

Query: 427  TLIQWKSNVNKFSLMEENSPLHIAAGFGYI---DIVKLLMENGAVV 555
             L++  ++ N+ S     +PL IA   GYI   D++K++ +  +VV
Sbjct: 748  LLLKNGASPNEVS-SNGTTPLAIAKRLGYISVTDVLKVVTDETSVV 792

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 25/97 (25%), Positives = 47/97 (48%)
 Frame = +1

Query: 268 STGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKS 447
           + G T LH + + G+V+  + L+ + A    + + G+ P+  A     +   + L++  +
Sbjct: 497 TAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDA 556

Query: 448 NVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
           + N        +PLH+A     +DIVKLL+  G   H
Sbjct: 557 HPNAAG-KNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 592

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 28/131 (21%), Positives = 60/131 (45%), Gaps = 28/131 (21%)
 Frame = +1

Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
           +++A+   G T L+ + +  ++E++ +L+  GA      ++G+ P++ A    H N V  
Sbjct: 99  NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 158

Query: 430 LIQW----------------KSNVNKFSLMEEN------------SPLHIAAGFGYIDIV 525
           LI +                  +    +++ +N            +PLHIAA +  +++ 
Sbjct: 159 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 218

Query: 526 KLLMENGAVVH 558
           +LL+  GA V+
Sbjct: 219 QLLLNRGASVN 229

 Score = 38.5 bits (88), Expect = 0.011
 Identities = 24/88 (27%), Positives = 46/88 (52%)
 Frame = +1

Query: 295 SGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLME 474
           + ++GN++  +  +  G  I + +QNG   +  A    H+  V  L+  K  + + +  +
Sbjct: 15  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH-KEIILETTTKK 73

Query: 475 ENSPLHIAAGFGYIDIVKLLMENGAVVH 558
            N+ LHIAA  G  ++V+ L+  GA V+
Sbjct: 74  GNTALHIAALAGQDEVVRELVNYGANVN 101
>sp|O70445|BARD1_MOUSE BRCA1-associated RING domain protein 1 (BARD-1)
          Length = 765

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 34/96 (35%), Positives = 54/96 (56%)
 Frame = +1

Query: 262 KDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQW 441
           ++  G T LH +   G++  + YL+  G      D  GW P+  AC++ H+  V+ L+Q 
Sbjct: 412 RNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDHAGWTPLHEACSHGHLKVVELLLQH 471

Query: 442 KSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
            + VN     + +SPLH A   G+IDIVK+L+ +GA
Sbjct: 472 NALVNTPG-YQNDSPLHDAVKSGHIDIVKVLLSHGA 506

 Score = 29.3 bits (64), Expect = 7.0
 Identities = 13/41 (31%), Positives = 25/41 (60%)
 Frame = +1

Query: 286 LHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANN 408
           LH + K+G+++++  L+S GA   +++  G RP+ Y    N
Sbjct: 486 LHDAVKSGHIDIVKVLLSHGASRNAVNIFGVRPVDYTDNEN 526
>sp|Q8WXE0|CSKI2_HUMAN Caskin-2
          Length = 1202

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 36/136 (26%), Positives = 74/136 (54%), Gaps = 1/136 (0%)
 Frame = +1

Query: 139 KEIKLINAAKSNKFEDLRKLF-EXXXXXXXXXXXXENIDIDAKDSTGMTALHFSGKNGNV 315
           +E  LI A K+     ++KL  +            + ++++ +D+ G +ALH +   G++
Sbjct: 3   REQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSL 62

Query: 316 EMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLMEENSPLHI 495
           E++  L+   A ++  D NG RP+ YA     +  V+ L++  + VN  SL +   PLH+
Sbjct: 63  ELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASL-DGQIPLHL 121

Query: 496 AAGFGYIDIVKLLMEN 543
           AA +G+ ++ ++L+++
Sbjct: 122 AAQYGHYEVSEMLLQH 137

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 3/100 (3%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           +D KDS GM  LH++   G +E +  L+   A + +   +G  P+  A    H    + L
Sbjct: 75  VDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEML 134

Query: 433 IQWKSN---VNKFSLMEENSPLHIAAGFGYIDIVKLLMEN 543
           +Q +SN   VNK     + +PL +A  FG + + +LL+ +
Sbjct: 135 LQHQSNPCLVNK----AKKTPLDLACEFGRLKVAQLLLNS 170
>sp|Q8VHK1|CSKI2_MOUSE Caskin-2
          Length = 1201

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 30/101 (29%), Positives = 62/101 (61%)
 Frame = +1

Query: 241 ENIDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINA 420
           + ++I+ +D+ G +ALH +   G++E++  L+   A ++  D NG RP+ YA     +  
Sbjct: 38  KRLNINYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEP 97

Query: 421 VKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMEN 543
           V+ L++  + VN  SL +   PLH+AA +G+ ++ ++L+++
Sbjct: 98  VRLLLRASAAVNAASL-DGQIPLHLAAQYGHYEVSEMLLQH 137

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 30/100 (30%), Positives = 51/100 (51%), Gaps = 3/100 (3%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           +D KDS GM  LH++   G +E +  L+   A + +   +G  P+  A    H    + L
Sbjct: 75  VDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEML 134

Query: 433 IQWKSN---VNKFSLMEENSPLHIAAGFGYIDIVKLLMEN 543
           +Q +SN   VNK     + +PL +A  FG + + +LL+ +
Sbjct: 135 LQHQSNPCLVNKL----KKTPLDLACEFGRLKVAQLLLNS 170
>sp|Q01484|ANK2_HUMAN Ankyrin-2 (Brain ankyrin) (Ankyrin B) (Ankyrin, nonerythroid)
          Length = 3924

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 35/101 (34%), Positives = 58/101 (57%)
 Frame = +1

Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVK 426
           IDI+  +  G+ ALH + K G+V ++  L+ RG+ ++S  + G   +  A        VK
Sbjct: 55  IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114

Query: 427 TLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
            L++  +N+N  S     +PL++AA   +ID+VK L+ENGA
Sbjct: 115 VLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGA 154

 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 34/99 (34%), Positives = 60/99 (60%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           IDAK   G+T LH + ++G+ +++  L+ RGA + +  +NG  P+  A   +H+  VK L
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351

Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           +Q K+ V+  +L +  + LH+AA  G+  + KLL++  A
Sbjct: 352 LQHKAPVDDVTL-DYLTALHVAAHCGHYRVTKLLLDKRA 389

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 34/100 (34%), Positives = 59/100 (59%)
 Frame = +1

Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
           +A+   G T LH + K   +++M  LV  GA I++I ++G  PI  A    H+N V  L+
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451

Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
           Q  ++ +  ++  E + LH+AA  G +++V+ L+ NGA+V
Sbjct: 452 QNGASPDVTNIRGETA-LHMAARAGQVEVVRCLLRNGALV 490

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           +D+    G TALH +   G  E++  LV  GA I +  QNG+ P+  A   NHI+ VK L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 433 IQWKSNVNKFSLMEEN-SPLHIAAGFGYIDIVKLLMEN 543
           ++  +  N+ +  E+  +PL +A   G+   V +L+EN
Sbjct: 150 LE--NGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 29/101 (28%), Positives = 54/101 (53%)
 Frame = +1

Query: 256 DAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLI 435
           D+    G+T LH +    N ++ + L+ +GA   +  +NG+ P+  A   N +    TL+
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649

Query: 436 QWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
            + +  N     +  +PLH+A+  G+ D+V LL++ GA +H
Sbjct: 650 NYGAETN-IVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 34/108 (31%), Positives = 55/108 (50%), Gaps = 6/108 (5%)
 Frame = +1

Query: 244 NIDIDAK------DSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACAN 405
           N D+ +K        +G T LH +   GNV +   L++RGA ++   +NG  P+  A   
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKR 276

Query: 406 NHINAVKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
            + N VK L+     ++     +  +PLH AA  G+  +V+LL+E GA
Sbjct: 277 GNTNMVKLLLDRGGQIDA-KTRDGLTPLHCAARSGHDQVVELLLERGA 323

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 28/92 (30%), Positives = 55/92 (59%), Gaps = 1/92 (1%)
 Frame = +1

Query: 277 MTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVN 456
           +TALH +   G+  +   L+ + A   +   NG+ P+  AC  N I  ++ L+++ +++ 
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425

Query: 457 KFSLMEEN-SPLHIAAGFGYIDIVKLLMENGA 549
             ++ E   +P+H+AA  G+++IV LL++NGA
Sbjct: 426 --AITESGLTPIHVAAFMGHLNIVLLLLQNGA 455

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 30/95 (31%), Positives = 48/95 (50%)
 Frame = +1

Query: 250  DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
            D DA    G T L  +   GNV+M+ +L+ +GA + +  +NG+ P+  A    H + +  
Sbjct: 720  DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINV 779

Query: 430  LIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLL 534
            L+Q  +  N  +    N+ L IA   GYI +V  L
Sbjct: 780  LLQHGAKPNA-TTANGNTALAIAKRLGYISVVDTL 813

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 32/104 (30%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           +D     G+T LH + K GN  M+  L+ RG  I++  ++G  P+  A  + H   V+ L
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318

Query: 433 IQWKSNV---NKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
           ++  + +    K  L    SPLH+AA   +++ VK L+++ A V
Sbjct: 319 LERGAPLLARTKNGL----SPLHMAAQGDHVECVKHLLQHKAPV 358

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 28/100 (28%), Positives = 52/100 (52%)
 Frame = +1

Query: 250 DIDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKT 429
           +I     +G+T+LH + +   V +   L   GA  ++  + G+ P+  AC   ++  V  
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNF 746

Query: 430 LIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           L++  +NVN        +PLH AA  G+  I+ +L+++GA
Sbjct: 747 LLKQGANVNA-KTKNGYTPLHQAAQQGHTHIINVLLQHGA 785

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 24/99 (24%), Positives = 50/99 (50%)
 Frame = +1

Query: 253 IDAKDSTGMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTL 432
           +DA+     T LH + + G  E++  L+   A  ++   NG+ P+  +     ++    L
Sbjct: 490 VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549

Query: 433 IQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGA 549
           ++     +  +  +  +PLH+AA +G +D+ KLL++  A
Sbjct: 550 LE-AGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 25/88 (28%), Positives = 50/88 (56%)
 Frame = +1

Query: 295 SGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNVNKFSLME 474
           + + GN++ +V  +  G  I + +QNG   +  A    H+  V+ L+   S+V+  +  +
Sbjct: 38  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS-ATKK 96

Query: 475 ENSPLHIAAGFGYIDIVKLLMENGAVVH 558
            N+ LHIA+  G  ++VK+L++ GA ++
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANIN 124

 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 23/95 (24%), Positives = 50/95 (52%)
 Frame = +1

Query: 274 GMTALHFSGKNGNVEMMVYLVSRGACIESIDQNGWRPISYACANNHINAVKTLIQWKSNV 453
           G+T LH + + G+ +M+  L+ +GA I    ++G   +  A   + +N    L +  ++ 
Sbjct: 662 GVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721

Query: 454 NKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVVH 558
           +  + +   +PL +A  +G + +V  L++ GA V+
Sbjct: 722 DAHTKL-GYTPLIVACHYGNVKMVNFLLKQGANVN 755

 Score = 37.4 bits (85), Expect = 0.026
 Identities = 25/111 (22%), Positives = 50/111 (45%), Gaps = 8/111 (7%)
 Frame = +1

Query: 247 IDIDAKDSTGMTALHFSGKNGNVEMMVYL--------VSRGACIESIDQNGWRPISYACA 402
           ++ D K    + ALH + +  + +    L        V     +    ++G+ P+  A  
Sbjct: 183 LENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAH 242

Query: 403 NNHINAVKTLIQWKSNVNKFSLMEENSPLHIAAGFGYIDIVKLLMENGAVV 555
             ++N V TL+  +     F+     +PLH+A+  G  ++VKLL++ G  +
Sbjct: 243 YGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQI 292
  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,570,921
Number of Sequences: 369166
Number of extensions: 751569
Number of successful extensions: 2802
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1774
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2508
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4029688280
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)