Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01631
(810 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (T... 63 1e-09
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 62 1e-09
sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin) 62 2e-09
sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G) 60 9e-09
sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TN... 59 1e-08
sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4... 59 1e-08
sp|Q13418|ILK1_HUMAN Integrin-linked protein kinase 1 (ILK-... 56 1e-07
sp|P57043|ILK2_HUMAN Integrin-linked protein kinase 2 (ILK-2) 56 1e-07
sp|P57044|ILK_CAVPO Integrin-linked protein kinase (Beta-in... 56 1e-07
sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H... 54 4e-07
>sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (TNKS-2) (TRF1-interacting
ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like
protein) (Tankyrase-related protein)
Length = 1166
Score = 62.8 bits (151), Expect = 1e-09
Identities = 33/98 (33%), Positives = 48/98 (48%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A GR +V+ L+ N + + G P+H AC FGH ++
Sbjct: 61 PLHFAAGFGRKDVVEYLLQNGANVQA--------------RDDGGLIPLHNACSFGHAEV 106
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
V LL+ + D NA + W Y P+H A KG ID+ +L+
Sbjct: 107 VNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 144
Score = 58.9 bits (141), Expect = 2e-08
Identities = 27/98 (27%), Positives = 50/98 (51%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A R+ +V+ L+ + ++ + G P+H AC +GH ++
Sbjct: 529 PLHFAAGYNRVSVVEYLLQHGADVHA--------------KDKGGLVPLHNACSYGHYEV 574
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
+LL+ + +N ++ WK+ P+H A KG +I K+L+
Sbjct: 575 AELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Score = 53.9 bits (128), Expect = 5e-07
Identities = 21/55 (38%), Positives = 34/55 (61%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
G P+H A +GH+D+ LLI +NA++KW + P+H A +KG + +L+A
Sbjct: 712 GLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Score = 53.1 bits (126), Expect = 9e-07
Identities = 23/99 (23%), Positives = 50/99 (50%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A R+ +V++L+ + ++ + P+H AC +GH ++
Sbjct: 214 PLHLAAGYNRVKIVQLLLQHGADVHA--------------KDKGDLVPLHNACSYGHYEV 259
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
+LL+ + +NA + W++ P+H A K +++ +L++
Sbjct: 260 TELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 298
Score = 48.5 bits (114), Expect = 2e-05
Identities = 22/78 (28%), Positives = 43/78 (55%), Gaps = 3/78 (3%)
Frame = +3
Query: 486 PIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CI 665
P+HLA + ++++ + L+ + D+NA +K P+H A GH+D+A +L+ C+
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNA---CV 738
Query: 666 YCGE---YQPIHFACRDG 710
+ + P+H A + G
Sbjct: 739 NATDKWAFTPLHEAAQKG 756
Score = 35.0 bits (79), Expect = 0.24
Identities = 13/52 (25%), Positives = 31/52 (59%)
Frame = +3
Query: 486 PIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
P+H+A + H D+V++++ ++ +NA + +H A GH+ ++L++
Sbjct: 403 PLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLS 454
Score = 31.2 bits (69), Expect = 3.5
Identities = 23/97 (23%), Positives = 42/97 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH+ACS G + ++L+ + ++ + + P+H A G +I
Sbjct: 562 PLHNACSYGHYEVAELLVKHGAVVNVADL--------------WKFTPLHEAAAKGKYEI 607
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKIL 635
KLL+ + D N+ P+ ++ G DI +L
Sbjct: 608 CKLLLQHGADPTKKNRDGNTPLD-LVKDGDTDIQDLL 643
Score = 30.8 bits (68), Expect = 4.6
Identities = 14/39 (35%), Positives = 22/39 (56%)
Frame = +3
Query: 522 IVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
I +LL+ +IN K P+H A EK H D+ +++V
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 62.4 bits (150), Expect = 1e-09
Identities = 36/126 (28%), Positives = 58/126 (46%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH G + + VLI + +D+ G P+H+A +G+I +
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDAT--------------TRMGYTPLHVASHYGNIKL 716
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
VK L+ ++ D+NA K Y P+H A ++GH DI +L+ + P+ A R
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKR 776
Query: 705 DGYIDI 722
GYI +
Sbjct: 777 LGYISV 782
Score = 60.1 bits (144), Expect = 7e-09
Identities = 38/141 (26%), Positives = 63/141 (44%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH AC + ++++L+ ID+V G P+H+A GH+ I
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAV--------------TESGLTPLHVASFMGHLPI 419
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
VK L+ N SN P+H A GH ++AK L+ + + P+H A R
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 705 DGYIDIFENID*NKCDINAST 767
G+ ++ + + N + N +T
Sbjct: 480 IGHTNMVKLLLENNANPNLAT 500
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/128 (25%), Positives = 59/128 (46%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G + K L+ N ++++ P+H A + GH ++
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNA--------------KAKDDQTPLHCAARIGHTNM 485
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
VKLL++N + N + + P+H A +GH++ L+ K+ C+ + P+H A +
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAK 545
Query: 705 DGYIDIFE 728
G + + E
Sbjct: 546 YGKVRVAE 553
Score = 57.8 bits (138), Expect = 3e-08
Identities = 29/97 (29%), Positives = 51/97 (52%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+HLA + GH ++V LL+ + + N NK P+H ++GH+ +A +L+ +
Sbjct: 635 GVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMV 694
Query: 657 *CIYCGEYQPIHFACRDGYIDIFENID*NKCDINAST 767
Y P+H A G I + + + ++ D+NA T
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Score = 57.0 bits (136), Expect = 6e-08
Identities = 36/142 (25%), Positives = 63/142 (44%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A NG + + ++L+ + I + G PIH+A + H+D
Sbjct: 275 PLHCAARNGHVRISEILLDHGAPIQA--------------KTKNGLSPIHMAAQGDHLDC 320
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
V+LL+ +I+ P+H A GH +AK+L+ K + P+H AC+
Sbjct: 321 VRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 380
Query: 705 DGYIDIFENID*NKCDINASTD 770
++ + E + I+A T+
Sbjct: 381 KNHVRVMELLLKTGASIDAVTE 402
Score = 53.5 bits (127), Expect = 7e-07
Identities = 37/139 (26%), Positives = 61/139 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G + KVL+ + +S G P+H+ACK H+ +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNS--------------RALNGFTPLHIACKKNHVRV 386
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
++LL+ I+A + P+H A GH+ I K L+ + P+H A R
Sbjct: 387 MELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 705 DGYIDIFENID*NKCDINA 761
G+ ++ + + NK +NA
Sbjct: 447 AGHTEVAKYLLQNKAKVNA 465
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/123 (25%), Positives = 53/123 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G + +V++L+ +I++ P+H A + GH+ I
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIET--------------KTKDELTPLHCAARNGHVRI 287
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
++L+D+ I A K PIH A + H+D ++L+ I P+H A
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347
Query: 705 DGY 713
G+
Sbjct: 348 CGH 350
Score = 48.9 bits (115), Expect = 2e-05
Identities = 22/86 (25%), Positives = 45/86 (52%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+H+A K+G + + +LL++ NA+ K P+H A+ ++DI K+L+ +
Sbjct: 536 GFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 657 *CIYCGEYQPIHFACRDGYIDIFENI 734
Y P+H A + +++ ++
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSL 621
Score = 47.4 bits (111), Expect = 5e-05
Identities = 24/81 (29%), Positives = 41/81 (50%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+H+A + G++ +V+LL+D I K + P+H A GH+ I++IL+
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 657 *CIYCGEYQPIHFACRDGYID 719
PIH A + ++D
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLD 319
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/126 (23%), Positives = 53/126 (42%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G +VK+L+ N+ + G P+H+A + GH++
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLA--------------TTAGHTPLHIAAREGHVET 518
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
V L++ + K + P+H A + G + +A++L+ + P+H A
Sbjct: 519 VLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVH 578
Query: 705 DGYIDI 722
+DI
Sbjct: 579 HNNLDI 584
Score = 44.3 bits (103), Expect = 4e-04
Identities = 23/97 (23%), Positives = 51/97 (52%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+H+A + ++++ +LL++ +N + + P+H A +G++ + ++L+ +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 657 *CIYCGEYQPIHFACRDGYIDIFENID*NKCDINAST 767
E P+H A R+G++ I E + + I A T
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Score = 43.9 bits (102), Expect = 5e-04
Identities = 29/141 (20%), Positives = 62/141 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A + + +VK+L+ S G P+H+A K +++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHS--------------PAWNGYTPLHIAAKQNQVEV 617
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
+ L+ NA + P+H A ++GH ++ +L++KQ P+H +
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 705 DGYIDIFENID*NKCDINAST 767
+G++ + + + + ++A+T
Sbjct: 678 EGHVPVADVLIKHGVMVDATT 698
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/99 (28%), Positives = 43/99 (43%)
Frame = +3
Query: 339 WRPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHI 518
+ PLH A G I LVK L+ + ++++ G P+H A + GH
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNA--------------KTKLGYSPLHQAAQQGHT 747
Query: 519 DIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKIL 635
DIV LL+ N N + P+ A G+I + +L
Sbjct: 748 DIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 39.7 bits (91), Expect = 0.010
Identities = 15/54 (27%), Positives = 34/54 (62%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
G P+++A + H+++VK L++N + N + + + P+ AL++GH ++ L+
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Score = 36.2 bits (82), Expect = 0.11
Identities = 13/54 (24%), Positives = 33/54 (61%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
G +H+A G ++V+ L++ ++NA ++ + P++ A ++ H+++ K L+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 131
Score = 31.6 bits (70), Expect = 2.7
Identities = 20/98 (20%), Positives = 45/98 (45%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G +HLA K GH+ +V L+ + + + K +H A G ++ + LV
Sbjct: 45 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 657 *CIYCGEYQPIHFACRDGYIDIFENID*NKCDINASTD 770
+ P++ A ++ ++++ + + N + N +T+
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 142
>sp|Q02357|ANK1_MOUSE Ankyrin-1 (Erythrocyte ankyrin)
Length = 1862
Score = 62.0 bits (149), Expect = 2e-09
Identities = 36/126 (28%), Positives = 58/126 (46%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH G + + VLI + +D+ G P+H+A +G+I +
Sbjct: 667 PLHLVSQEGHVLVADVLIKHGVTVDAT--------------TRMGYTPLHVASHYGNIKL 712
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
VK L+ ++ D+NA K Y P+H A ++GH DI +L+ + P+ A R
Sbjct: 713 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKR 772
Query: 705 DGYIDI 722
GYI +
Sbjct: 773 LGYISV 778
Score = 58.2 bits (139), Expect = 3e-08
Identities = 39/141 (27%), Positives = 61/141 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH AC I ++++L+ ID+V G P+H+A GH+ I
Sbjct: 370 PLHIACKKNHIRVMELLLKTGASIDAV--------------TESGLTPLHVASFMGHLPI 415
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
VK L+ N SN P+H A GH ++AK L+ + + P+H A R
Sbjct: 416 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAAR 475
Query: 705 DGYIDIFENID*NKCDINAST 767
G+ + + + N N +T
Sbjct: 476 IGHTGMVKLLLENGASPNLAT 496
Score = 57.8 bits (138), Expect = 3e-08
Identities = 37/142 (26%), Positives = 63/142 (44%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A NG + + ++L+ + I + G PIH+A + H+D
Sbjct: 271 PLHCAARNGHVRISEILLDHGAPIQA--------------KTKNGLSPIHMAAQGDHLDC 316
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
V+LL+ +I+ P+H A GH +AK+L+ K + P+H AC+
Sbjct: 317 VRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK 376
Query: 705 DGYIDIFENID*NKCDINASTD 770
+I + E + I+A T+
Sbjct: 377 KNHIRVMELLLKTGASIDAVTE 398
Score = 57.0 bits (136), Expect = 6e-08
Identities = 34/128 (26%), Positives = 57/128 (44%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G + K L+ N + ++ P+H A + GH +
Sbjct: 436 PLHMAARAGHTEVAKYLLQNKAKANA--------------KAKDDQTPLHCAARIGHTGM 481
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
VKLL++N N + + P+H A +GH+D A L+ K+ C+ + P+H A +
Sbjct: 482 VKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAK 541
Query: 705 DGYIDIFE 728
G + + E
Sbjct: 542 YGKVRLAE 549
Score = 56.2 bits (134), Expect = 1e-07
Identities = 29/97 (29%), Positives = 51/97 (52%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+HLA + GH ++V LL+ + + N NK P+H ++GH+ +A +L+ +
Sbjct: 631 GVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVLVADVLIKHGVTV 690
Query: 657 *CIYCGEYQPIHFACRDGYIDIFENID*NKCDINAST 767
Y P+H A G I + + + ++ D+NA T
Sbjct: 691 DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 727
Score = 52.8 bits (125), Expect = 1e-06
Identities = 38/158 (24%), Positives = 64/158 (40%), Gaps = 19/158 (12%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*I-------------------VFSXXXXXXXXX 467
P+H A + V++L+ + EID + + V
Sbjct: 304 PIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSR 363
Query: 468 XXYGCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQ 647
G P+H+ACK HI +++LL+ I+A + P+H A GH+ I K L+ +
Sbjct: 364 ALNGFTPLHIACKKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 423
Query: 648 M*Y*CIYCGEYQPIHFACRDGYIDIFENID*NKCDINA 761
P+H A R G+ ++ + + NK NA
Sbjct: 424 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANA 461
Score = 50.4 bits (119), Expect = 6e-06
Identities = 34/150 (22%), Positives = 63/150 (42%), Gaps = 20/150 (13%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCE--------------------IDSV*IVFSXXXXXXXX 464
PLH A G G+VK+L+ N +D+ +
Sbjct: 469 PLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTA-LALLEKEASQAC 527
Query: 465 XXXYGCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAK 644
G P+H+A K+G + + +LL+++ NA+ K P+H A+ ++DI K+L+ +
Sbjct: 528 MTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPR 587
Query: 645 QM*Y*CIYCGEYQPIHFACRDGYIDIFENI 734
Y P+H A + I++ ++
Sbjct: 588 GGSPHSPAWNGYTPLHIAAKQNQIEVARSL 617
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/123 (25%), Positives = 53/123 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G + +V++L+ +I++ P+H A + GH+ I
Sbjct: 238 PLHIASRRGNVIMVRLLLDRGAQIET--------------RTKDELTPLHCAARNGHVRI 283
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
++L+D+ I A K PIH A + H+D ++L+ I P+H A
Sbjct: 284 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAH 343
Query: 705 DGY 713
G+
Sbjct: 344 CGH 346
Score = 47.0 bits (110), Expect = 6e-05
Identities = 24/81 (29%), Positives = 41/81 (50%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+H+A + G++ +V+LL+D I K + P+H A GH+ I++IL+
Sbjct: 235 GITPLHIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPI 294
Query: 657 *CIYCGEYQPIHFACRDGYID 719
PIH A + ++D
Sbjct: 295 QAKTKNGLSPIHMAAQGDHLD 315
Score = 44.3 bits (103), Expect = 4e-04
Identities = 23/97 (23%), Positives = 51/97 (52%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+H+A + ++++ +LL++ +N + + P+H A +G++ + ++L+ +
Sbjct: 202 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 261
Query: 657 *CIYCGEYQPIHFACRDGYIDIFENID*NKCDINAST 767
E P+H A R+G++ I E + + I A T
Sbjct: 262 ETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 298
Score = 43.5 bits (101), Expect = 7e-04
Identities = 30/141 (21%), Positives = 62/141 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A + + +VK+L+ S G P+H+A K I++
Sbjct: 568 PLHVAVHHNNLDIVKLLLPRGGSPHS--------------PAWNGYTPLHIAAKQNQIEV 613
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
+ L+ NA + P+H A ++GH ++ +L++KQ P+H +
Sbjct: 614 ARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQ 673
Query: 705 DGYIDIFENID*NKCDINAST 767
+G++ + + + + ++A+T
Sbjct: 674 EGHVLVADVLIKHGVTVDATT 694
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/99 (28%), Positives = 43/99 (43%)
Frame = +3
Query: 339 WRPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHI 518
+ PLH A G I LVK L+ + ++++ G P+H A + GH
Sbjct: 698 YTPLHVASHYGNIKLVKFLLQHQADVNA--------------KTKLGYSPLHQAAQQGHT 743
Query: 519 DIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKIL 635
DIV LL+ N N + P+ A G+I + +L
Sbjct: 744 DIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVL 782
Score = 39.7 bits (91), Expect = 0.010
Identities = 15/54 (27%), Positives = 34/54 (62%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
G P+++A + H+++VK L++N + N + + + P+ AL++GH ++ L+
Sbjct: 107 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 160
Score = 36.2 bits (82), Expect = 0.11
Identities = 13/54 (24%), Positives = 33/54 (61%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
G +H+A G ++V+ L++ ++NA ++ + P++ A ++ H+++ K L+
Sbjct: 74 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 127
Score = 31.6 bits (70), Expect = 2.7
Identities = 20/98 (20%), Positives = 45/98 (45%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G +HLA K GH+ +V L+ + + + K +H A G ++ + LV
Sbjct: 41 GLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 100
Query: 657 *CIYCGEYQPIHFACRDGYIDIFENID*NKCDINASTD 770
+ P++ A ++ ++++ + + N + N +T+
Sbjct: 101 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATE 138
>sp|Q12955|ANK3_HUMAN Ankyrin-3 (ANK-3) (Ankyrin G)
Length = 4377
Score = 59.7 bits (143), Expect = 9e-09
Identities = 36/143 (25%), Positives = 64/143 (44%)
Frame = +3
Query: 339 WRPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHI 518
+ PLH A ++ + L+ + ++V G +HLA + GH+
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAV--------------TRQGIASVHLAAQEGHV 677
Query: 519 DIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFA 698
D+V LL+ ++N SNK P+H A ++ +++A++LV + Y P+H
Sbjct: 678 DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG 737
Query: 699 CRDGYIDIFENID*NKCDINAST 767
C G I I + + +NA T
Sbjct: 738 CHYGNIKIVNFLLQHSAKVNAKT 760
Score = 58.5 bits (140), Expect = 2e-08
Identities = 33/130 (25%), Positives = 57/130 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A R+ + +VL++ +D+ G P+H+ C +G+I I
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDA--------------QTKMGYTPLHVGCHYGNIKI 745
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
V L+ + +NA K Y P+H A ++GH I +L+ + + A R
Sbjct: 746 VNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805
Query: 705 DGYIDIFENI 734
GYI + + +
Sbjct: 806 LGYISVVDTL 815
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/141 (25%), Positives = 59/141 (41%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH AC RI ++++L+ + I +V G PIH+A GH++I
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAV--------------TESGLTPIHVAAFMGHVNI 448
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
V L+ + N +N +H A G ++ + LV + P+H + R
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 705 DGYIDIFENID*NKCDINAST 767
G DI + + NA+T
Sbjct: 509 LGKADIVQQLLQQGASPNAAT 529
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/175 (21%), Positives = 66/175 (37%), Gaps = 33/175 (18%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G +VK+L+ +ID+ G P+H + GH +
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDA--------------KTRDGLTPLHCGARSGHEQV 316
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM------------*Y*CIY 668
V++L+D I + K P+H A + H++ ++L+ + + +
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAH 376
Query: 669 CGEYQ---------------------PIHFACRDGYIDIFENID*NKCDINASTD 770
CG Y+ P+H AC+ I + E + + I A T+
Sbjct: 377 CGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE 431
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/144 (22%), Positives = 61/144 (42%)
Frame = +3
Query: 333 KFWRPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFG 512
K + PLH A G++ + +L+ D+ G P+H+A +
Sbjct: 564 KGFTPLHVAAKYGKLEVANLLLQKSASPDAA--------------GKSGLTPLHVAAHYD 609
Query: 513 HIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIH 692
+ + LL+D +A+ K Y P+H A +K +DIA L+ + +H
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 693 FACRDGYIDIFENID*NKCDINAS 764
A ++G++D+ + ++N S
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLS 693
Score = 47.0 bits (110), Expect = 6e-05
Identities = 30/130 (23%), Positives = 56/130 (43%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A + V++L+ ++ +D V + +H+A GH +
Sbjct: 337 PLHMATQGDHLNCVQLLLQHNVPVDDVTNDY--------------LTALHVAAHCGHYKV 382
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
K+L+D K + NA + P+H A +K I + ++L+ + PIH A
Sbjct: 383 AKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAF 442
Query: 705 DGYIDIFENI 734
G+++I +
Sbjct: 443 MGHVNIVSQL 452
Score = 44.7 bits (104), Expect = 3e-04
Identities = 22/97 (22%), Positives = 46/97 (47%)
Frame = +3
Query: 348 LHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDIV 527
LH A G + +V L+ +D+ G +H+A G ++V
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAA--------------TKKGNTALHIASLAGQAEVV 123
Query: 528 KLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
K+L+ N ++NA ++ + P++ A ++ H+++ K L+
Sbjct: 124 KVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL 160
Score = 44.7 bits (104), Expect = 3e-04
Identities = 24/97 (24%), Positives = 49/97 (50%)
Frame = +3
Query: 348 LHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDIV 527
LH A G+ +VKVL++N +++ G P+++A + H+++V
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNA--------------QSQNGFTPLYMAAQENHLEVV 156
Query: 528 KLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
K L+DN + + + + P+ AL++GH + +L+
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/125 (21%), Positives = 55/125 (44%)
Frame = +3
Query: 348 LHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDIV 527
LH A +G+ +V+ L+ + ++++ P+H++ + G DIV
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEA--------------KAKDDQTPLHISARLGKADIV 515
Query: 528 KLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACRD 707
+ L+ NA+ Y P+H + +GH D+A L+ + P+H A +
Sbjct: 516 QQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKY 575
Query: 708 GYIDI 722
G +++
Sbjct: 576 GKLEV 580
Score = 44.7 bits (104), Expect = 3e-04
Identities = 17/56 (30%), Positives = 34/56 (60%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAK 644
G P+HL+ + GH D+ L+D+ ++ + K + P+H A + G +++A +L+ K
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Score = 42.7 bits (99), Expect = 0.001
Identities = 19/82 (23%), Positives = 42/82 (51%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G +HLA K GH+++V L+ + +++A+ K +H A G ++ K+LV
Sbjct: 74 GLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133
Query: 657 *CIYCGEYQPIHFACRDGYIDI 722
+ P++ A ++ ++++
Sbjct: 134 NAQSQNGFTPLYMAAQENHLEV 155
Score = 42.7 bits (99), Expect = 0.001
Identities = 28/125 (22%), Positives = 52/125 (41%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A G I + +L++ +D P+H+A K G+ ++
Sbjct: 238 PLHIAAHYGNINVATLLLNRAAAVDFT--------------ARNDITPLHVASKRGNANM 283
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFACR 704
VKLL+D I+A + P+H GH + ++L+ + P+H A +
Sbjct: 284 VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQ 343
Query: 705 DGYID 719
+++
Sbjct: 344 GDHLN 348
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/84 (22%), Positives = 43/84 (51%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+H+A +G+I++ LL++ ++ + + P+H A ++G+ ++ K+L+ +
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
Query: 657 *CIYCGEYQPIHFACRDGYIDIFE 728
P+H R G+ + E
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVE 318
Score = 33.9 bits (76), Expect = 0.54
Identities = 20/90 (22%), Positives = 41/90 (45%)
Frame = +3
Query: 498 ACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGE 677
A + GH++ I N DIN N+ +H A ++GH+++ L+ ++
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 678 YQPIHFACRDGYIDIFENID*NKCDINAST 767
+H A G ++ + + N ++NA +
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Score = 33.1 bits (74), Expect = 0.92
Identities = 20/93 (21%), Positives = 43/93 (46%)
Frame = +3
Query: 489 IHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIY 668
+H+A + LL+ N + + +K + P+H A G+I++A +L+ +
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTA 265
Query: 669 CGEYQPIHFACRDGYIDIFENID*NKCDINAST 767
+ P+H A + G ++ + + I+A T
Sbjct: 266 RNDITPLHVASKRGNANMVKLLLDRGAKIDAKT 298
>sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TNKS-1) (TRF1-interacting
ankyrin-related ADP-ribose polymerase)
Length = 1327
Score = 59.3 bits (142), Expect = 1e-08
Identities = 27/98 (27%), Positives = 50/98 (51%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A R+ +V+ L+ + ++ + G P+H AC +GH ++
Sbjct: 687 PLHFAAGYNRVSVVEYLLHHGADVHA--------------KDKGGLVPLHNACSYGHYEV 732
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
+LL+ + +N ++ WK+ P+H A KG +I K+L+
Sbjct: 733 AELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Score = 57.8 bits (138), Expect = 3e-08
Identities = 32/98 (32%), Positives = 46/98 (46%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A GR +V+ L+ + + G P+H AC FGH ++
Sbjct: 219 PLHFAAGFGRKDVVEHLLQMGANVHA--------------RDDGGLIPLHNACSFGHAEV 264
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILV 638
V LL+ D NA + W Y P+H A KG ID+ +L+
Sbjct: 265 VSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Score = 55.5 bits (132), Expect = 2e-07
Identities = 24/99 (24%), Positives = 51/99 (51%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A R+ +V++L+ + ++ + G P+H AC +GH ++
Sbjct: 372 PLHLAAGYNRVRIVQLLLQHGADVHA--------------KDKGGLVPLHNACSYGHYEV 417
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
+LL+ + +NA + W++ P+H A K +++ +L++
Sbjct: 418 TELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS 456
Score = 53.9 bits (128), Expect = 5e-07
Identities = 22/55 (40%), Positives = 34/55 (61%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
G P+H A +GH+DI LLI +NA++KW + P+H A +KG + +L+A
Sbjct: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA 924
Score = 49.7 bits (117), Expect = 1e-05
Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 3/78 (3%)
Frame = +3
Query: 486 PIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CI 665
P+HLA + ++++ + L+++ D+NA +K P+H A GH+DIA +L+ C+
Sbjct: 840 PLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT---CV 896
Query: 666 YCGE---YQPIHFACRDG 710
+ + P+H A + G
Sbjct: 897 NATDKWAFTPLHEAAQKG 914
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/127 (24%), Positives = 49/127 (38%)
Frame = +3
Query: 342 RPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHID 521
R L AC NG + VK L+ P+H A FG D
Sbjct: 184 RELLEACRNGDVSRVKRLVD-------------AANVNAKDMAGRKSSPLHFAAGFGRKD 230
Query: 522 IVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFAC 701
+V+ L+ +++A + P+H A GH ++ +L+ + Y P+H A
Sbjct: 231 VVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAA 290
Query: 702 RDGYIDI 722
G ID+
Sbjct: 291 IKGKIDV 297
Score = 32.0 bits (71), Expect = 2.1
Identities = 23/97 (23%), Positives = 43/97 (44%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH+ACS G + ++L+ + ++ + + P+H A G +I
Sbjct: 720 PLHNACSYGHYEVAELLVRHGASVNVADL--------------WKFTPLHEAAAKGKYEI 765
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKIL 635
KLL+ + D N+ P+ +++G DI +L
Sbjct: 766 CKLLLKHGADPTKKNRDGNTPLD-LVKEGDTDIQDLL 801
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
serine/threonine-protein kinase 4) (Ankyrin repeat domain
protein 3) (PKC-delta-interacting protein kinase)
Length = 832
Score = 59.3 bits (142), Expect = 1e-08
Identities = 37/141 (26%), Positives = 61/141 (43%)
Frame = +3
Query: 339 WRPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHI 518
W PLH+A G + +VK+L G P+HLA + GH
Sbjct: 619 WLPLHYAAWQGHLPIVKLLAKQ-------------PGVSVNAQTLDGRTPLHLAAQRGHY 665
Query: 519 DIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFA 698
+ ++LID D+N + P+H A E GH A++L+ + + Y +H A
Sbjct: 666 RVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLA 725
Query: 699 CRDGYIDIFENID*NKCDINA 761
R+G++ + + K D+ A
Sbjct: 726 ARNGHLATVKLLVEEKADVLA 746
Score = 55.8 bits (133), Expect = 1e-07
Identities = 31/103 (30%), Positives = 51/103 (49%)
Frame = +3
Query: 339 WRPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHI 518
W LH A NG ++L+ + ++ V G P+H+AC+ G
Sbjct: 553 WTALHFAAQNGDESSTRLLLEKNASVNEV--------------DFEGRTPMHVACQHGQE 598
Query: 519 DIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQ 647
+IV++L+ D++ K + P+HYA +GH+ I K+L AKQ
Sbjct: 599 NIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL-AKQ 640
Score = 41.6 bits (96), Expect = 0.003
Identities = 19/55 (34%), Positives = 30/55 (54%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
G +HLA + GH+ VKLL++ K D+ A +H A GH ++ + LV+
Sbjct: 718 GYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS 772
Score = 39.3 bits (90), Expect = 0.013
Identities = 21/82 (25%), Positives = 42/82 (51%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G P+H+A + +V+LL+ K +NA ++ ++ +H+A + G ++L+ K
Sbjct: 519 GSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV 578
Query: 657 *CIYCGEYQPIHFACRDGYIDI 722
+ P+H AC+ G +I
Sbjct: 579 NEVDFEGRTPMHVACQHGQENI 600
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/78 (26%), Positives = 42/78 (53%)
Frame = +3
Query: 477 GCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y 656
G +HLA + G + K L+ N + N SN+ P+H A+E+ + ++L+A+++
Sbjct: 486 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 545
Query: 657 *CIYCGEYQPIHFACRDG 710
++ +HFA ++G
Sbjct: 546 NAKDEDQWTALHFAAQNG 563
>sp|Q13418|ILK1_HUMAN Integrin-linked protein kinase 1 (ILK-1) (59 kDa
serine/threonine-protein kinase) (p59ILK)
Length = 452
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/99 (36%), Positives = 48/99 (48%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH AC GR +V++LI I+ + P+HLA GH DI
Sbjct: 37 PLHWACREGRSAVVEMLIMRGARINVM--------------NRGDDTPLHLAASHGHRDI 82
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
V+ L+ K DINA N+ P+HYA G +A+ LVA
Sbjct: 83 VQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVA 121
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/87 (29%), Positives = 43/87 (49%)
Frame = +3
Query: 474 YGCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM* 653
+G P+H AC+ G +V++LI IN N+ P+H A GH DI + L+ +
Sbjct: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
Query: 654 Y*CIYCGEYQPIHFACRDGYIDIFENI 734
+ P+H+AC G + E++
Sbjct: 93 INAVNEHGNVPLHYACFWGQDQVAEDL 119
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Frame = +3
Query: 489 IHLACKFGHIDIVKLLIDN-KCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CI 665
I C+ G+ V+L +DN + D+N + + P+H+A +G + ++L+ + +
Sbjct: 4 IFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVM 63
Query: 666 YCGEYQPIHFACRDGYIDIFENID*NKCDINA 761
G+ P+H A G+ DI + + K DINA
Sbjct: 64 NRGDDTPLHLAASHGHRDIVQKLLQYKADINA 95
Score = 35.4 bits (80), Expect = 0.19
Identities = 22/85 (25%), Positives = 39/85 (45%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A S+G +V+ L+ +I++V +G P+H AC +G +
Sbjct: 70 PLHLAASHGHRDIVQKLLQYKADINAV--------------NEHGNVPLHYACFWGQDQV 115
Query: 525 VKLLIDNKCDINASNKWKYQPIHYA 599
+ L+ N ++ NK+ P+ A
Sbjct: 116 AEDLVANGALVSICNKYGEMPVDKA 140
>sp|P57043|ILK2_HUMAN Integrin-linked protein kinase 2 (ILK-2)
Length = 452
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/99 (36%), Positives = 48/99 (48%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH AC GR +V++LI I+ + P+HLA GH DI
Sbjct: 37 PLHWACREGRSAVVEMLIMRGARINVM--------------NRGDDTPLHLAASHGHRDI 82
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
V+ L+ K DINA N+ P+HYA G +A+ LVA
Sbjct: 83 VQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVA 121
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/87 (29%), Positives = 43/87 (49%)
Frame = +3
Query: 474 YGCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM* 653
+G P+H AC+ G +V++LI IN N+ P+H A GH DI + L+ +
Sbjct: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
Query: 654 Y*CIYCGEYQPIHFACRDGYIDIFENI 734
+ P+H+AC G + E++
Sbjct: 93 INAVNEHGNVPLHYACFWGQDQVAEDL 119
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Frame = +3
Query: 489 IHLACKFGHIDIVKLLIDN-KCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CI 665
I C+ G+ V+L +DN + D+N + + P+H+A +G + ++L+ + +
Sbjct: 4 IFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVM 63
Query: 666 YCGEYQPIHFACRDGYIDIFENID*NKCDINA 761
G+ P+H A G+ DI + + K DINA
Sbjct: 64 NRGDDTPLHLAASHGHRDIVQKLLQYKADINA 95
Score = 35.4 bits (80), Expect = 0.19
Identities = 22/85 (25%), Positives = 39/85 (45%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A S+G +V+ L+ +I++V +G P+H AC +G +
Sbjct: 70 PLHLAASHGHRDIVQKLLQYKADINAV--------------NEHGNVPLHYACFWGQDQV 115
Query: 525 VKLLIDNKCDINASNKWKYQPIHYA 599
+ L+ N ++ NK+ P+ A
Sbjct: 116 AEDLVANGALVSICNKYGEMPVDKA 140
>sp|P57044|ILK_CAVPO Integrin-linked protein kinase (Beta-integrin-linked kinase)
Length = 451
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/99 (36%), Positives = 48/99 (48%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH AC GR +V++LI I+ + P+HLA GH DI
Sbjct: 37 PLHWACREGRSAVVEMLIMRGARINVM--------------NRGDDTPLHLAASHGHRDI 82
Query: 525 VKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVA 641
V+ L+ K DINA N+ P+HYA G +A+ LVA
Sbjct: 83 VQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVA 121
Score = 47.8 bits (112), Expect = 4e-05
Identities = 26/87 (29%), Positives = 43/87 (49%)
Frame = +3
Query: 474 YGCQPIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM* 653
+G P+H AC+ G +V++LI IN N+ P+H A GH DI + L+ +
Sbjct: 33 HGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKAD 92
Query: 654 Y*CIYCGEYQPIHFACRDGYIDIFENI 734
+ P+H+AC G + E++
Sbjct: 93 INAVNEHGNVPLHYACFWGQDQVAEDL 119
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 1/92 (1%)
Frame = +3
Query: 489 IHLACKFGHIDIVKLLIDN-KCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CI 665
I C+ G+ V+L +DN + D+N + + P+H+A +G + ++L+ + +
Sbjct: 4 IFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVM 63
Query: 666 YCGEYQPIHFACRDGYIDIFENID*NKCDINA 761
G+ P+H A G+ DI + + K DINA
Sbjct: 64 NRGDDTPLHLAASHGHRDIVQKLLQYKADINA 95
Score = 34.7 bits (78), Expect = 0.32
Identities = 22/85 (25%), Positives = 39/85 (45%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PLH A S+G +V+ L+ +I++V +G P+H AC +G +
Sbjct: 70 PLHLAASHGHRDIVQKLLQYKADINAV--------------NEHGNVPLHYACFWGQDQV 115
Query: 525 VKLLIDNKCDINASNKWKYQPIHYA 599
+ L+ N ++ NK+ P+ A
Sbjct: 116 AEDLVANGALVSICNKYGEMPMDKA 140
>sp|Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (Histone
H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic
histone-lysine N-methyltransferase 1) (Eu-HMTase1)
(G9a-like protein 1) (GLP1)
Length = 1267
Score = 54.3 bits (129), Expect = 4e-07
Identities = 40/140 (28%), Positives = 64/140 (45%), Gaps = 1/140 (0%)
Frame = +3
Query: 345 PLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHIDI 524
PL A N + VK LI +D G +HLA K GH ++
Sbjct: 778 PLMEAAENNHLEAVKYLIKAGALVDP--------------KDAEGSTCLHLAAKKGHYEV 823
Query: 525 VKLLIDN-KCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIHFAC 701
V+ L+ N + D+N + + P+ +A E H+D+ K+L++K E +H+A
Sbjct: 824 VQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAA 883
Query: 702 RDGYIDIFENID*NKCDINA 761
G +DI E + KCD++A
Sbjct: 884 FSGCVDIAEILLAAKCDLHA 903
Score = 50.1 bits (118), Expect = 7e-06
Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 5/129 (3%)
Frame = +3
Query: 348 LHHACSNGRIGLVKVLISN-----HCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFG 512
LH A G +V+ L+SN +C+ D G P+ A ++
Sbjct: 812 LHLAAKKGHYEVVQYLLSNGQMDVNCQDDG------------------GWTPMIWATEYK 853
Query: 513 HIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CIYCGEYQPIH 692
H+D+VKLL+ DIN + + +H+A G +DIA+IL+A + + P+H
Sbjct: 854 HVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLH 913
Query: 693 FACRDGYID 719
A R+ D
Sbjct: 914 IAARENRYD 922
Score = 37.7 bits (86), Expect = 0.037
Identities = 22/96 (22%), Positives = 45/96 (46%), Gaps = 1/96 (1%)
Frame = +3
Query: 486 PIHLACKFGHIDIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAKQM*Y*CI 665
P+H A + GH+DI +L+ +I+ ++ + P+ A E H++ K L+
Sbjct: 745 PLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPK 804
Query: 666 YCGEYQPIHFACRDGYIDIFENID*N-KCDINASTD 770
+H A + G+ ++ + + N + D+N D
Sbjct: 805 DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDD 840
Score = 35.8 bits (81), Expect = 0.14
Identities = 25/102 (24%), Positives = 44/102 (43%)
Frame = +3
Query: 339 WRPLHHACSNGRIGLVKVLISNHCEIDSV*IVFSXXXXXXXXXXXYGCQPIHLACKFGHI 518
W P+ A + LVK+L+S +I+ C +H A G +
Sbjct: 843 WTPMIWATEYKHVDLVKLLLSKGSDIN------------IRDNEENIC--LHWAAFSGCV 888
Query: 519 DIVKLLIDNKCDINASNKWKYQPIHYALEKGHIDIAKILVAK 644
DI ++L+ KCD++A N P+H A + D + +++
Sbjct: 889 DIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSR 930
Score = 30.4 bits (67), Expect = 6.0
Identities = 16/52 (30%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Frame = +3
Query: 489 IHLACKFGHIDIVKLLIDNKCDIN--ASNKWKYQPIHYALEKGHIDIAKILV 638
++ + + G + V L++ + D N ++ K P+H A E GH+DI +LV
Sbjct: 711 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLV 762
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,003,372
Number of Sequences: 369166
Number of extensions: 1222574
Number of successful extensions: 4382
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3131
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4055
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)