Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01618
(909 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60347|TBC12_HUMAN TBC1 domain family member 12 216 7e-56
sp|Q8CGA2|TBC14_MOUSE TBC1 domain family member 14 181 3e-45
sp|Q9P2M4|TBC14_HUMAN TBC1 domain family member 14 180 4e-45
sp|Q80XC3|US6NL_MOUSE USP6 N-terminal-like protein 87 8e-17
sp|Q92738|US6NL_HUMAN USP6 N-terminal-like protein (Related... 86 1e-16
sp|Q09844|YAE3_SCHPO Hypothetical protein C23D3.03c in chro... 83 9e-16
sp|Q9BXI6|TBC10_HUMAN TBC1 domain family member 10A (EBP50-... 82 2e-15
sp|P58802|TBC10_MOUSE TBC1 domain family member 10A (EBP50-... 81 5e-15
sp|Q9BYX2|TBCD2_HUMAN TBC1 domain family member 2 (Prostate... 75 2e-13
sp|P53258|GYP2_YEAST GTPase-activating protein GYP2 (MAC1-d... 70 8e-12
>sp|O60347|TBC12_HUMAN TBC1 domain family member 12
Length = 769
Score = 216 bits (550), Expect = 7e-56
Identities = 117/295 (39%), Positives = 164/295 (55%)
Frame = +3
Query: 24 VWRNFILPNWFHQQTSQYVRHLWWEGIPTSVRDKVWRQCIPNTLKLTKTHYDNFLSQMQE 203
+W N ILPNW ++++ VR LWW+G+P SVR KVW + N L +T Y+ FLS+ +E
Sbjct: 453 IWINEILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKE 512
Query: 204 RIERYLEPVSQDDLATKATDKPNTEIDLNNRNGTHISPTVESKSSAAYDLYFTETVSIHN 383
R + + S++S+ D TE VS+ +
Sbjct: 513 RWKSF------------------------------------SETSSEND---TEGVSVAD 533
Query: 384 KRSSSLSYXXXXXXXXXXXXXXDVDIRQILLNTIKLDVSRTFPHLNLFQDGGPHHDLLYQ 563
+ +S L IKLD+SRTFP L +FQ GGP+HD+L+
Sbjct: 534 REAS--------------------------LELIKLDISRTFPSLYIFQKGGPYHDVLHS 567
Query: 564 LLGAYACYRPDIGYVQGMSFLAAVLILVMNVEDAFICFANILELPCHHAFYALDESEFTV 743
+LGAY CYRPD+GYVQGMSF+AAVLIL + DAFI FAN+L PC AF+ +D S
Sbjct: 568 ILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLK 627
Query: 744 YLESFKLLLFTHLPQLAQHFIQHKLDVNIFLCDWLFTIYSRALPLETALRVWDIF 908
Y +F++ +L +L HF + L +I+L DW+FT+YS++LPL+ A RVWD+F
Sbjct: 628 YFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVF 682
>sp|Q8CGA2|TBC14_MOUSE TBC1 domain family member 14
Length = 679
Score = 181 bits (459), Expect = 3e-45
Identities = 79/149 (53%), Positives = 111/149 (74%)
Frame = +3
Query: 462 RQILLNTIKLDVSRTFPHLNLFQDGGPHHDLLYQLLGAYACYRPDIGYVQGMSFLAAVLI 641
R+ L IKLD+SRTFP+L +FQ GGP+HD+L+ +LGAY CYRPD+GYVQGMSF+AAVLI
Sbjct: 445 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 504
Query: 642 LVMNVEDAFICFANILELPCHHAFYALDESEFTVYLESFKLLLFTHLPQLAQHFIQHKLD 821
L ++ DAFI F+N+L PC AF+ +D Y +F++ +LP+L HF ++ L
Sbjct: 505 LNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLT 564
Query: 822 VNIFLCDWLFTIYSRALPLETALRVWDIF 908
+I+L DW+FT+YS++LPL+ A R+WD+F
Sbjct: 565 ADIYLIDWIFTLYSKSLPLDLACRIWDVF 593
Score = 64.3 bits (155), Expect = 4e-10
Identities = 30/60 (50%), Positives = 37/60 (61%)
Frame = +3
Query: 27 WRNFILPNWFHQQTSQYVRHLWWEGIPTSVRDKVWRQCIPNTLKLTKTHYDNFLSQMQER 206
W N ILPNW S+ VR LWW+GIP SVR KVW I N L +T +D L++ +ER
Sbjct: 363 WNNEILPNWETMWCSKKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKER 422
>sp|Q9P2M4|TBC14_HUMAN TBC1 domain family member 14
Length = 678
Score = 180 bits (457), Expect = 4e-45
Identities = 79/149 (53%), Positives = 111/149 (74%)
Frame = +3
Query: 462 RQILLNTIKLDVSRTFPHLNLFQDGGPHHDLLYQLLGAYACYRPDIGYVQGMSFLAAVLI 641
R+ L IKLD+SRTFP+L +FQ GGP+HD+L+ +LGAY CYRPD+GYVQGMSF+AAVLI
Sbjct: 444 REASLELIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 503
Query: 642 LVMNVEDAFICFANILELPCHHAFYALDESEFTVYLESFKLLLFTHLPQLAQHFIQHKLD 821
L ++ DAFI F+N+L PC AF+ +D Y +F++ +LP+L HF ++ L
Sbjct: 504 LNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLT 563
Query: 822 VNIFLCDWLFTIYSRALPLETALRVWDIF 908
+I+L DW+FT+YS++LPL+ A R+WD+F
Sbjct: 564 PDIYLIDWIFTLYSKSLPLDLACRIWDVF 592
Score = 64.3 bits (155), Expect = 4e-10
Identities = 30/60 (50%), Positives = 37/60 (61%)
Frame = +3
Query: 27 WRNFILPNWFHQQTSQYVRHLWWEGIPTSVRDKVWRQCIPNTLKLTKTHYDNFLSQMQER 206
W N ILPNW S+ VR LWW+GIP SVR KVW I N L +T +D L++ +ER
Sbjct: 362 WNNEILPNWETMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKER 421
>sp|Q80XC3|US6NL_MOUSE USP6 N-terminal-like protein
Length = 819
Score = 86.7 bits (213), Expect = 8e-17
Identities = 51/154 (33%), Positives = 77/154 (50%), Gaps = 3/154 (1%)
Frame = +3
Query: 456 DIRQILLNTIKLDVSRTFPHLNLFQDG-GPHHDLLYQLLGAYACYRPDIGYVQGMSFLAA 632
DIRQI LDV+RTF +F+D G L+ +L AY+ Y ++GY QGMS + A
Sbjct: 140 DIRQI-----DLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITA 194
Query: 633 VLILVMNVEDAFICFANILELPCH--HAFYALDESEFTVYLESFKLLLFTHLPQLAQHFI 806
+L++ MN EDAF + P H H F+ + + E + +L L +L QH
Sbjct: 195 LLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLD 254
Query: 807 QHKLDVNIFLCDWLFTIYSRALPLETALRVWDIF 908
++ + + W F + P LR+WDI+
Sbjct: 255 SQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIY 288
>sp|Q92738|US6NL_HUMAN USP6 N-terminal-like protein (Related to the N terminus of tre)
(RN-tre)
Length = 828
Score = 86.3 bits (212), Expect = 1e-16
Identities = 51/154 (33%), Positives = 77/154 (50%), Gaps = 3/154 (1%)
Frame = +3
Query: 456 DIRQILLNTIKLDVSRTFPHLNLFQDG-GPHHDLLYQLLGAYACYRPDIGYVQGMSFLAA 632
DIRQI LDV+RTF +F+D G L+ +L AY+ Y ++GY QGMS + A
Sbjct: 140 DIRQI-----DLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITA 194
Query: 633 VLILVMNVEDAFICFANILELPCH--HAFYALDESEFTVYLESFKLLLFTHLPQLAQHFI 806
+L++ MN EDAF + P H H F+ + + E + +L L +L QH
Sbjct: 195 LLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLD 254
Query: 807 QHKLDVNIFLCDWLFTIYSRALPLETALRVWDIF 908
++ + + W F + P LR+WDI+
Sbjct: 255 SQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIY 288
>sp|Q09844|YAE3_SCHPO Hypothetical protein C23D3.03c in chromosome I
Length = 472
Score = 83.2 bits (204), Expect = 9e-16
Identities = 51/143 (35%), Positives = 77/143 (53%), Gaps = 1/143 (0%)
Frame = +3
Query: 483 IKLDVSRTFPHLNLFQDGGPHHDLLYQLLGAYACYRPDIGYVQGMSFLAAVLILVMNVED 662
++LD+ T PH +LF GP L LL AY+ YR D Y+ G SF+ A+L+L MN+
Sbjct: 272 LELDLQSTMPHYSLFHTEGPLRRDLIGLLRAYSYYRFDTSYIPGTSFIGALLLLNMNLTS 331
Query: 663 AFICFANILELPCHHAFYALDESEFTVYLESFKLLLFTHLPQLAQH-FIQHKLDVNIFLC 839
AF C AN+L+ P A Y D S + ++F L + P+LA H I+ +L + F+
Sbjct: 332 AFNCLANLLDKPFLQAVYTQDTSSLKSFYQTFLDTLKKNEPELATHLLIKLELVPDDFVY 391
Query: 840 DWLFTIYSRALPLETALRVWDIF 908
L ++ + E A R+ D +
Sbjct: 392 PLLRKLFIPMVSPEIASRILDCY 414
Score = 48.1 bits (113), Expect = 3e-05
Identities = 24/64 (37%), Positives = 33/64 (51%)
Frame = +3
Query: 15 LTHVWRNFILPNWFHQQTSQYVRHLWWEGIPTSVRDKVWRQCIPNTLKLTKTHYDNFLSQ 194
L +VW IL NW S +W +GIP+ VR +VW + I N LKL + N +
Sbjct: 187 LVNVWEREILRNWPDALKSSRYAGIWRQGIPSRVRGRVWEKAIGNNLKLDYQSFFNARAN 246
Query: 195 MQER 206
Q+R
Sbjct: 247 AQKR 250
>sp|Q9BXI6|TBC10_HUMAN TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa)
(EPI64 protein)
Length = 508
Score = 82.4 bits (202), Expect = 2e-15
Identities = 51/148 (34%), Positives = 76/148 (51%), Gaps = 3/148 (2%)
Frame = +3
Query: 474 LNTIKLDVSRTFPHLNLFQDGGPHHDL-LYQLLGAYACYRPDIGYVQGMSFLAAVLILVM 650
L+ I+ D+ R FP +F G H L+++L AY YRP+ GY Q + +AAVL++ M
Sbjct: 151 LDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHM 210
Query: 651 NVEDAFICFANILE--LPCHHAFYALDESEFTVYLESFKLLLFTHLPQLAQHFIQHKLDV 824
E AF C I E LP +Y+ + E LL P +H + K+D
Sbjct: 211 PAEQAFWCLVQICEKYLP---GYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDP 267
Query: 825 NIFLCDWLFTIYSRALPLETALRVWDIF 908
+++ +W +SR LP + LRVWD+F
Sbjct: 268 LLYMTEWFMCAFSRTLPWSSVLRVWDMF 295
>sp|P58802|TBC10_MOUSE TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa)
(EPI64 protein)
Length = 500
Score = 80.9 bits (198), Expect = 5e-15
Identities = 49/148 (33%), Positives = 76/148 (51%), Gaps = 3/148 (2%)
Frame = +3
Query: 474 LNTIKLDVSRTFPHLNLFQDGGPHHDL-LYQLLGAYACYRPDIGYVQGMSFLAAVLILVM 650
L+ I+ D+ R FP +F G H L+++L AY YRP+ GY Q + +AAVL++ M
Sbjct: 151 LDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHM 210
Query: 651 NVEDAFICFANILE--LPCHHAFYALDESEFTVYLESFKLLLFTHLPQLAQHFIQHKLDV 824
E AF C + E LP +Y+ + E LL P +H + K+D
Sbjct: 211 PAEQAFWCLVQVCEKYLP---GYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDP 267
Query: 825 NIFLCDWLFTIYSRALPLETALRVWDIF 908
+++ +W ++R LP + LRVWD+F
Sbjct: 268 LLYMTEWFMCAFARTLPWSSVLRVWDMF 295
>sp|Q9BYX2|TBCD2_HUMAN TBC1 domain family member 2 (Prostate antigen recognized and
indentified by SEREX) (PARIS-1)
Length = 917
Score = 75.5 bits (184), Expect = 2e-13
Identities = 48/144 (33%), Positives = 76/144 (52%), Gaps = 2/144 (1%)
Frame = +3
Query: 483 IKLDVSRTFPHLNLFQ-DGGPHHDLLYQLLGAYACYRPDIGYVQGMSFLAAVLILVMNVE 659
I+LD++RTFP+ F D L ++L A++ P IGY QG++ LAA+ +LV+ E
Sbjct: 670 IELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEE 729
Query: 660 D-AFICFANILELPCHHAFYALDESEFTVYLESFKLLLFTHLPQLAQHFIQHKLDVNIFL 836
+ AF C I+E +Y + V + LL LP+L H QH +D+++
Sbjct: 730 ESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVT 789
Query: 837 CDWLFTIYSRALPLETALRVWDIF 908
+W +++ +L LRVWD F
Sbjct: 790 FNWFLVVFADSLISNILLRVWDAF 813
>sp|P53258|GYP2_YEAST GTPase-activating protein GYP2 (MAC1-dependent regulator) (MIC1
protein)
Length = 950
Score = 70.1 bits (170), Expect = 8e-12
Identities = 42/152 (27%), Positives = 82/152 (53%), Gaps = 7/152 (4%)
Frame = +3
Query: 474 LNTIKLDVSRTFPHLNLFQ-DGGPHHDLLYQLLGAYACYRPDIGYVQGMSFLAAVLILVM 650
++ I+ D+ R+ P + +Q + G L +L AY+ PD+GY Q M+ + A ++ M
Sbjct: 286 IDEIEKDLKRSLPEYSAYQTEEGIQR--LRNVLTAYSWKNPDVGYCQAMNIVVAGFLIFM 343
Query: 651 NVEDAFICFANILEL--PCHHA--FYA--LDESEFTVYLESFKLLLFTHLPQLAQHFIQH 812
+ E AF C N+ ++ P +++ Y LD+ F ++E +P L ++ +QH
Sbjct: 344 SEEQAFWCLCNLCDIYVPGYYSKTMYGTLLDQRVFESFVED-------RMPVLWEYILQH 396
Query: 813 KLDVNIFLCDWLFTIYSRALPLETALRVWDIF 908
+ +++ W +++ ++PLE A+R+ DIF
Sbjct: 397 DIQLSVVSLPWFLSLFFTSMPLEYAVRIMDIF 428
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,059,588
Number of Sequences: 369166
Number of extensions: 2051255
Number of successful extensions: 5131
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4923
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5096
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9222552960
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)