Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= DrC_01296
(605 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q86YT6|MIB1_HUMAN Ubiquitin ligase protein MIB1 (Mind bo... 50 6e-06
sp|Q80SY4|MIB1_MOUSE Ubiquitin ligase protein MIB1 (Mind bo... 49 1e-05
sp|Q6GNY1|MIB1_XENLA Ubiquitin ligase protein MIB1 (Mind bo... 48 2e-05
sp|Q804S5|MIB1_BRARE Ubiquitin ligase protein mib (Mind bom... 48 2e-05
sp|Q9VUX2|MIB_DROME Ubiquitin ligase protein mind-bomb (Min... 44 2e-04
sp|Q96CA5|BIRC7_HUMAN Baculoviral IAP repeat-containing pro... 44 4e-04
sp|Q96AX9|MIB2_HUMAN Ubiquitin ligase protein MIB2 (Mind bo... 44 4e-04
sp|Q5ZIJ9|MIB2_CHICK Ubiquitin ligase protein MIB2 (Mind bo... 42 0.001
sp|Q8R516|MIB2_MOUSE Ubiquitin ligase protein MIB2 (Mind bo... 42 0.001
sp|Q68LP1|MIB2_RAT Ubiquitin ligase protein MIB2 (Mind bomb... 42 0.001
>sp|Q86YT6|MIB1_HUMAN Ubiquitin ligase protein MIB1 (Mind bomb homolog 1) (DAPK-interacting
protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin
repeat domain protein 2)
Length = 1006
Score = 49.7 bits (117), Expect = 6e-06
Identities = 40/159 (25%), Positives = 66/159 (41%), Gaps = 8/159 (5%)
Frame = +2
Query: 47 IIMYLIEKGAKLDLRNNDGKTPIDCCGDDSLKIKLKNMSSEK------SQQANMKASTSE 208
I +L GA L +RN G++P+D C D +L L EK S+ +M ++ SE
Sbjct: 755 IACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSGQVGSRSPSMISNDSE 814
Query: 209 LVMTKFRTISETQLATRIPNVAPVQISESVGPPVAKTXXXXXXXXXXXXXXMKDRKICII 388
+ + S+ + T + P V K + C++
Sbjct: 815 -TLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKI-----EECVV 868
Query: 389 CRDRPMNITF-GCGHM-SCDVCANNLFECHICRGPTNQK 499
C D+ + F CGHM +C+ CAN + +C CR ++
Sbjct: 869 CSDKKAAVLFQPCGHMCACENCANLMKKCVQCRAVVERR 907
Score = 47.4 bits (111), Expect = 3e-05
Identities = 17/40 (42%), Positives = 27/40 (67%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICR 481
+K++ +C +C DR N+ F CGH +C +C + + EC ICR
Sbjct: 957 IKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICR 996
Score = 38.5 bits (88), Expect = 0.013
Identities = 40/175 (22%), Positives = 71/175 (40%), Gaps = 29/175 (16%)
Frame = +2
Query: 44 EIIMYLIEKGAKLDLRNNDGKTPI-DCCGDDSLK--IKLKNMSSEKSQQANMKASTSELV 214
+I+ L+ GAKLD+++ DG TP+ + +L +L++M A + S + L+
Sbjct: 680 QIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLI 739
Query: 215 MTKFRTISETQLATRI-----PNVAPVQISESVG---------PPVAKTXXXXXXXXXXX 352
M +E + A I N A + I G P + K
Sbjct: 740 MGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPNLCKALAKCHKEKVSG 799
Query: 353 XXXMKDRKI----------CIICRDRPMNITFG-CGHM-SCDVCANNLFECHICR 481
+ + C++C D + FG CGH+ +C +C+ + +C IC+
Sbjct: 800 QVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICK 854
>sp|Q80SY4|MIB1_MOUSE Ubiquitin ligase protein MIB1 (Mind bomb homolog 1) (DAPK-interacting
protein 1) (DIP-1)
Length = 1006
Score = 48.9 bits (115), Expect = 1e-05
Identities = 40/159 (25%), Positives = 66/159 (41%), Gaps = 8/159 (5%)
Frame = +2
Query: 47 IIMYLIEKGAKLDLRNNDGKTPIDCCGDDSLKIKLKNMSSEK------SQQANMKASTSE 208
I +L GA L +RN G++P+D C D SL L EK S+ +M ++ SE
Sbjct: 755 IACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKVSGQVGSRSPSMISNDSE 814
Query: 209 LVMTKFRTISETQLATRIPNVAPVQISESVGPPVAKTXXXXXXXXXXXXXXMKDRKICII 388
+ + S+ + T + P V K + C++
Sbjct: 815 -TLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKI-----EECVV 868
Query: 389 CRDRPMNITF-GCGHM-SCDVCANNLFECHICRGPTNQK 499
C D+ + F CGHM +C+ CA+ + +C CR ++
Sbjct: 869 CSDKKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERR 907
Score = 47.4 bits (111), Expect = 3e-05
Identities = 17/40 (42%), Positives = 27/40 (67%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICR 481
+K++ +C +C DR N+ F CGH +C +C + + EC ICR
Sbjct: 957 IKEQTMCPVCLDRLKNMIFLCGHGTCQLCGDRMSECPICR 996
Score = 38.9 bits (89), Expect = 0.010
Identities = 40/175 (22%), Positives = 71/175 (40%), Gaps = 29/175 (16%)
Frame = +2
Query: 44 EIIMYLIEKGAKLDLRNNDGKTPI-DCCGDDSLK--IKLKNMSSEKSQQANMKASTSELV 214
+I+ L+ GAKLD+++ DG TP+ + +L +L++M A + S + L+
Sbjct: 680 QIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLI 739
Query: 215 MTKFRTISETQLATRI-----PNVAPVQISESVG---------PPVAKTXXXXXXXXXXX 352
M +E + A I N A + I G P + K
Sbjct: 740 MGLGTQGAEKKSAASIACFLAANGADLSIRNKKGQSPLDLCPDPSLCKALAKCHKEKVSG 799
Query: 353 XXXMKDRKI----------CIICRDRPMNITFG-CGHM-SCDVCANNLFECHICR 481
+ + C++C D + FG CGH+ +C +C+ + +C IC+
Sbjct: 800 QVGSRSPSMISNDSETLEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICK 854
>sp|Q6GNY1|MIB1_XENLA Ubiquitin ligase protein MIB1 (Mind bomb homolog 1)
Length = 1011
Score = 47.8 bits (112), Expect = 2e-05
Identities = 17/40 (42%), Positives = 27/40 (67%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICR 481
+K++ +C +C DR N+ F CGH +C +C + + EC ICR
Sbjct: 958 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICR 997
Score = 46.2 bits (108), Expect = 6e-05
Identities = 36/159 (22%), Positives = 64/159 (40%), Gaps = 8/159 (5%)
Frame = +2
Query: 47 IIMYLIEKGAKLDLRNNDGKTPIDCCGDDSLKIKLKNMSSEKSQQANMKASTSELVMTKF 226
I +L GA L +RN G++P+D C D +L L EKS + + + ++
Sbjct: 756 IACFLAANGADLAVRNKKGQSPLDLCPDPNLCKTLAKCHKEKS-SGQVGSHSPSMINNDS 814
Query: 227 RTISETQLATRIPN------VAPVQISESVGPPVAKTXXXXXXXXXXXXXXMKDRKICII 388
T+ E + + + + P V K + C++
Sbjct: 815 ETLEECMVCSDLKRDTLFGPCGHIATCSLCSPRVKKCLLCKEQVQSRTKI-----EECVV 869
Query: 389 CRDRPMNITF-GCGHM-SCDVCANNLFECHICRGPTNQK 499
C D+ + F CGHM +C+ CA+ + +C CR ++
Sbjct: 870 CSDKKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERR 908
>sp|Q804S5|MIB1_BRARE Ubiquitin ligase protein mib (Mind bomb protein)
Length = 1030
Score = 47.8 bits (112), Expect = 2e-05
Identities = 17/40 (42%), Positives = 27/40 (67%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICR 481
+K++ +C +C DR N+ F CGH +C +C + + EC ICR
Sbjct: 981 IKEQTMCPVCLDRLKNMIFMCGHGTCQLCGDRMSECPICR 1020
Score = 46.6 bits (109), Expect = 5e-05
Identities = 36/157 (22%), Positives = 63/157 (40%), Gaps = 6/157 (3%)
Frame = +2
Query: 47 IIMYLIEKGAKLDLRNNDGKTPIDCCGDDSLKIKLKNMSSEKSQ----QANMKASTSELV 214
I +L GA L +RN G++P+D C D SL L EK+ + +++
Sbjct: 754 IACFLAANGADLTIRNKKGQSPLDLCPDPSLCKALAKCHKEKTSGQVGSRSPSLNSNNET 813
Query: 215 MTKFRTISETQLATRIPNVAPVQISESVGPPVAKTXXXXXXXXXXXXXXMKDRKICIICR 394
+ + S+ + T + P V K + C++C
Sbjct: 814 LEECMVCSDMKRDTLFGPCGHIATCSLCSPRVKKCLICKEQVQSRTKI-----EECVVCS 868
Query: 395 DRPMNITF-GCGHM-SCDVCANNLFECHICRGPTNQK 499
D+ + F CGHM +C+ CA+ + +C CR ++
Sbjct: 869 DKKAAVLFQPCGHMCACENCASLMKKCVQCRAVVERR 905
>sp|Q9VUX2|MIB_DROME Ubiquitin ligase protein mind-bomb (Mind bomb homolog) (D-mib)
Length = 1226
Score = 44.3 bits (103), Expect = 2e-04
Identities = 16/40 (40%), Positives = 26/40 (65%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICR 481
+K++ +C +C DR N+ F CGH +C +C + + C ICR
Sbjct: 1177 IKEQTMCPVCFDRIKNMVFLCGHGTCQMCGDQIEGCPICR 1216
Score = 43.5 bits (101), Expect = 4e-04
Identities = 39/161 (24%), Positives = 61/161 (37%), Gaps = 16/161 (9%)
Frame = +2
Query: 47 IIMYLIEKGAKLDLRNNDGKTPIDCCGDDSLKIKLKNMSSEK--------------SQQA 184
I +L GA L L+N +TP+D C D +L L +E+ S A
Sbjct: 847 IACFLAANGADLTLKNRKQQTPLDLCPDPNLCKTLVKCYNERKTDDSELPGNVAGTSSSA 906
Query: 185 NMKASTSELVMTKFRTISETQLATRIPNVAPVQISESVGPPVAKTXXXXXXXXXXXXXXM 364
+A++ L + + + LA + P S S+
Sbjct: 907 RARAASGSLNQSSSVNMPLSSLAAS--STFPAASSSSIFALNGIANEMSQSLHEDPPKSS 964
Query: 365 KDRKICIICRDRPMNITFG-CGHMSC-DVCANNLFECHICR 481
C++C D + F CGH+SC + CA + +C ICR
Sbjct: 965 ASLDECLVCSDAKRDTVFKPCGHVSCCETCAPRVKKCLICR 1005
>sp|Q96CA5|BIRC7_HUMAN Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of
apoptosis protein) (KIAP) (Melanoma inhibitor of
apoptosis protein) (ML-IAP) (Livin)
Length = 298
Score = 43.5 bits (101), Expect = 4e-04
Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 1/47 (2%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITF-GCGHMSCDVCANNLFECHICRGPTNQK 499
+++ + C +C DR ++I F CGH+ C CA L C ICR P +
Sbjct: 246 LQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSR 292
>sp|Q96AX9|MIB2_HUMAN Ubiquitin ligase protein MIB2 (Mind bomb homolog 2) (Zinc finger ZZ
type with ankyrin repeat domain protein 1) (Skeletrophin)
(Novelzin) (Novel zinc finger protein) (Putative
NF-kappa-B-activating protein 002N)
Length = 1013
Score = 43.5 bits (101), Expect = 4e-04
Identities = 18/46 (39%), Positives = 25/46 (54%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICRGPTNQK 499
M++R C IC D + + F CGH +C C + L C ICR P +
Sbjct: 963 MEERITCPICIDSHIRLVFQCGHGACAPCGSALSACPICRQPIRDR 1008
>sp|Q5ZIJ9|MIB2_CHICK Ubiquitin ligase protein MIB2 (Mind bomb homolog 2)
Length = 954
Score = 42.0 bits (97), Expect = 0.001
Identities = 18/40 (45%), Positives = 23/40 (57%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICR 481
M++R C IC D + + F CGH SC C+ L C ICR
Sbjct: 904 MEERITCPICIDDQIKLVFQCGHGSCPDCSTALTVCPICR 943
Score = 35.4 bits (80), Expect = 0.11
Identities = 32/155 (20%), Positives = 61/155 (39%), Gaps = 4/155 (2%)
Frame = +2
Query: 47 IIMYLIEKGAKLDLRNNDGKTPIDCCGDDSLKIKLKNMSSE-KSQQANMKASTSELVMTK 223
I YL ++GA ++ N+ GK+P+D D + +K+ S + + QQ + S + +
Sbjct: 749 IACYLAQEGADINYANHRGKSPLDLITDGRIVQIIKDFSQKFREQQVSSDCSAITCSLRR 808
Query: 224 FRTISETQLATRIPNVA-PVQISESVGPPVAKTXXXXXXXXXXXXXXMKDRKICIICRDR 400
T T + +VA P + C++C +
Sbjct: 809 VHTTPNTMTNLSVSSVAVPTE--------------------------------CLVCSEL 836
Query: 401 PMNI-TFGCGH-MSCDVCANNLFECHICRGPTNQK 499
+ I F C H + C+ C+ + +C C+ +K
Sbjct: 837 ALLIHFFPCQHSIVCEECSRRMKKCIKCQVTITKK 871
>sp|Q8R516|MIB2_MOUSE Ubiquitin ligase protein MIB2 (Mind bomb homolog 2) (Mind bomb-2)
(Skeletrophin) (Dystrophin-like protein) (Dyslike)
Length = 973
Score = 42.0 bits (97), Expect = 0.001
Identities = 18/46 (39%), Positives = 24/46 (52%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICRGPTNQK 499
M++R C IC D + + F CGH +C C L C ICR P +
Sbjct: 923 MEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDR 968
>sp|Q68LP1|MIB2_RAT Ubiquitin ligase protein MIB2 (Mind bomb homolog 2)
(RBSC-skeletrophin/dystrophin-like polypeptide)
Length = 971
Score = 42.0 bits (97), Expect = 0.001
Identities = 18/46 (39%), Positives = 24/46 (52%)
Frame = +2
Query: 362 MKDRKICIICRDRPMNITFGCGHMSCDVCANNLFECHICRGPTNQK 499
M++R C IC D + + F CGH +C C L C ICR P +
Sbjct: 921 MEERITCPICIDSHIRLVFQCGHGACAPCGAALNACPICRQPIRDR 966
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,996,538
Number of Sequences: 369166
Number of extensions: 1157163
Number of successful extensions: 2937
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2779
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2934
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4699949280
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)