Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_N10
(464 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 99 4e-21
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 96 5e-20
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 96 5e-20
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 92 7e-19
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 91 1e-18
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 91 1e-18
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 90 2e-18
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 89 4e-18
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 83 3e-16
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 82 6e-16
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 99.4 bits (246), Expect = 4e-21
Identities = 49/126 (38%), Positives = 77/126 (61%), Gaps = 1/126 (0%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
++S FYT + GY++C R +G G G+GTHLSLYF +M GEFD +LQWPF+ V L L+
Sbjct: 428 VFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLL 487
Query: 189 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNAN-LILNNQIF 365
+Q + +H+ + K + PN + +P E NI G +F+ L + N I ++ +F
Sbjct: 488 DQSGKKNHIVETFKAD--PNSSSFKRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLF 545
Query: 366 IKCSVN 383
+K +V+
Sbjct: 546 LKVAVD 551
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 95.5 bits (236), Expect = 5e-20
Identities = 54/125 (43%), Positives = 71/125 (56%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
+YS FYT GYKMC RV +G G G+GTHLSL+F +M GE+D +L WPFK V L L+
Sbjct: 440 LYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLM 499
Query: 189 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNANLILNNQIFI 368
+Q + H+ K + PN + KP E NI G F+ L N I ++ IFI
Sbjct: 500 DQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFI 556
Query: 369 KCSVN 383
K V+
Sbjct: 557 KVIVD 561
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 95.5 bits (236), Expect = 5e-20
Identities = 54/125 (43%), Positives = 71/125 (56%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
+YS FYT GYKMC RV +G G G+GTHLSL+F +M GE+D +L WPFK V L L+
Sbjct: 439 LYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLM 498
Query: 189 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNANLILNNQIFI 368
+Q + H+ K + PN + KP E NI G F+ L N I ++ IFI
Sbjct: 499 DQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFI 555
Query: 369 KCSVN 383
K V+
Sbjct: 556 KVIVD 560
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 91.7 bits (226), Expect = 7e-19
Identities = 48/125 (38%), Positives = 74/125 (59%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
I+S +FYT ++GYKMCLR+ +G G G GTHLSL+F +M G D +L+WPF V L L+
Sbjct: 376 IFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLL 435
Query: 189 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNANLILNNQIFI 368
+Q R +HV + + + +PVN+ NI G F + ++ + + ++ IFI
Sbjct: 436 DQNNR-EHVIDAFRPD--VTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFI 492
Query: 369 KCSVN 383
K V+
Sbjct: 493 KAIVD 497
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 91.3 bits (225), Expect = 1e-18
Identities = 51/128 (39%), Positives = 74/128 (57%), Gaps = 3/128 (2%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
I+S +FYT ++GYKMCLRV +G G G GTHLSL+F +M G D +LQWPF V L L
Sbjct: 376 IFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLML- 434
Query: 189 NQQTRLDHVNKKIKYNDFPND---ELWNKPVNERNIGFGRSKFIELKELSTNANLILNNQ 359
LDH N++ + F D + +PV++ NI G F + ++ + + ++
Sbjct: 435 -----LDHNNREHVIDAFRPDVTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDA 489
Query: 360 IFIKCSVN 383
IFIK V+
Sbjct: 490 IFIKAIVD 497
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 91.3 bits (225), Expect = 1e-18
Identities = 49/126 (38%), Positives = 72/126 (57%), Gaps = 1/126 (0%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
I+S SFYT + GY++C R +G G G G+HLSLYF +M GEFD +LQWPF+ V L L+
Sbjct: 428 IFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLL 487
Query: 189 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNAN-LILNNQIF 365
+Q + N + PN + +P E NI G +F+ L N I ++ +F
Sbjct: 488 DQSGK---KNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLF 544
Query: 366 IKCSVN 383
+K +V+
Sbjct: 545 LKVAVD 550
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 90.1 bits (222), Expect = 2e-18
Identities = 46/131 (35%), Positives = 77/131 (58%), Gaps = 8/131 (6%)
Frame = +3
Query: 12 YSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLIN 191
+S +FYTHK+GYK+ + +G+G GEGTHLSLY ++ G FD++L+WPF V SL++
Sbjct: 333 FSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLD 392
Query: 192 QQ----TRLDHVNKKI----KYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNANLI 347
Q + HV + + +F W ++E ++GFG KFI +++ N +
Sbjct: 393 QSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDI-RKRNYV 451
Query: 348 LNNQIFIKCSV 380
++ +FI+ +V
Sbjct: 452 RDDAVFIRAAV 462
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 89.4 bits (220), Expect = 4e-18
Identities = 45/131 (34%), Positives = 76/131 (58%), Gaps = 8/131 (6%)
Frame = +3
Query: 12 YSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLIN 191
+S +FYTHK+GYK+ + +G+G GEGTHLS+Y ++ G FD++L+WP V SL++
Sbjct: 333 FSPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLARRVTFSLLD 392
Query: 192 QQ----TRLDHVNKKI----KYNDFPNDELWNKPVNERNIGFGRSKFIELKELSTNANLI 347
Q + HV + + +F W ++E ++GFG KFI +++ N +
Sbjct: 393 QSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDI-RKRNYV 451
Query: 348 LNNQIFIKCSV 380
++ +FI+ SV
Sbjct: 452 RDDAVFIRASV 462
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 82.8 bits (203), Expect = 3e-16
Identities = 43/126 (34%), Positives = 73/126 (57%), Gaps = 1/126 (0%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
++S +FYT K+GYK+CLR+ +G G G+ THLSL+ +M GE+D +L WPF+ V L+
Sbjct: 284 LFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLL 343
Query: 189 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKEL-STNANLILNNQIF 365
+Q R ++ + + + +P +E N+ G F L +L S + ++ +F
Sbjct: 344 DQNNREHAID---AFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMF 400
Query: 366 IKCSVN 383
+KC V+
Sbjct: 401 LKCIVD 406
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 82.0 bits (201), Expect = 6e-16
Identities = 43/125 (34%), Positives = 72/125 (57%), Gaps = 1/125 (0%)
Frame = +3
Query: 9 IYSDSFYTHKHGYKMCLRVDPDGHGDGEGTHLSLYFCLMIGEFDDILQWPFKYDVRLSLI 188
++S +FYT K+GYK+CLR+ +G G G+ THLSL+ +M GE+D +L WPF+ V L+
Sbjct: 291 LFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLL 350
Query: 189 NQQTRLDHVNKKIKYNDFPNDELWNKPVNERNIGFGRSKFIELKEL-STNANLILNNQIF 365
+Q R ++ + + + +P +E N+ G F L +L S + ++ +F
Sbjct: 351 DQNNREHAID---AFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMF 407
Query: 366 IKCSV 380
+KC V
Sbjct: 408 LKCIV 412
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,147,567
Number of Sequences: 369166
Number of extensions: 837337
Number of successful extensions: 2330
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2220
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2314
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2633927485
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)