Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_N08
(594 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P47811|MK14_MOUSE Mitogen-activated protein kinase 14 (M... 242 6e-64
sp|P70618|MK14_RAT Mitogen-activated protein kinase 14 (Mit... 242 6e-64
sp|Q16539|MK14_HUMAN Mitogen-activated protein kinase 14 (M... 241 1e-63
sp|Q95NE7|MK14_PANTR Mitogen-activated protein kinase 14 (M... 241 1e-63
sp|O02812|MK14_CANFA Mitogen-activated protein kinase 14 (M... 241 1e-63
sp|Q90336|MK14A_CYPCA Mitogen-activated protein kinase 14a ... 241 1e-63
sp|Q9DGE2|MK14A_BRARE Mitogen-activated protein kinase 14a ... 238 6e-63
sp|Q9I958|MK14B_CYPCA Mitogen-activated protein kinase 14b ... 235 7e-62
sp|P47812|MK14_XENLA Mitogen-activated protein kinase 14 (M... 234 1e-61
sp|Q9DGE1|MK14B_BRARE Mitogen-activated protein kinase 14b ... 233 4e-61
>sp|P47811|MK14_MOUSE Mitogen-activated protein kinase 14 (Mitogen-activated protein
kinase p38 alpha) (MAP kinase p38 alpha) (CRK1)
Length = 360
Score = 242 bits (617), Expect = 6e-64
Identities = 113/178 (63%), Positives = 142/178 (79%)
Frame = +1
Query: 46 ISDNMSEFQLHNIAHSDWNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFH 225
+S F + + W VP RY+NL+P+G GAYGSVCAAFD K +VA+KKL+RPF
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ 60
Query: 226 SPEYAKRTYRELKIIHHMDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQ 405
S +AKRTYREL+++ HM HEN++ L+D FTP + E F DVYL+T LMGADLN I++ Q
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 406 ELLNEHVQFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
+L ++HVQFL+YQILRGLKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 178
>sp|P70618|MK14_RAT Mitogen-activated protein kinase 14 (Mitogen-activated protein
kinase p38 alpha) (MAP kinase p38 alpha) (CRK1)
Length = 360
Score = 242 bits (617), Expect = 6e-64
Identities = 113/178 (63%), Positives = 142/178 (79%)
Frame = +1
Query: 46 ISDNMSEFQLHNIAHSDWNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFH 225
+S F + + W VP RY+NL+P+G GAYGSVCAAFD K +VA+KKL+RPF
Sbjct: 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ 60
Query: 226 SPEYAKRTYRELKIIHHMDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQ 405
S +AKRTYREL+++ HM HEN++ L+D FTP + E F DVYL+T LMGADLN I++ Q
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 406 ELLNEHVQFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
+L ++HVQFL+YQILRGLKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 178
>sp|Q16539|MK14_HUMAN Mitogen-activated protein kinase 14 (Mitogen-activated protein
kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine
suppressive anti-inflammatory drug binding protein)
(CSAID binding protein) (CSBP) (MAX-interacting protein
2) (MAP kinase MXI2) (SAPK2A)
Length = 360
Score = 241 bits (615), Expect = 1e-63
Identities = 113/178 (63%), Positives = 142/178 (79%)
Frame = +1
Query: 46 ISDNMSEFQLHNIAHSDWNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFH 225
+S F + + W VP RY+NL+P+G GAYGSVCAAFD K +VA+KKL+RPF
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 226 SPEYAKRTYRELKIIHHMDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQ 405
S +AKRTYREL+++ HM HEN++ L+D FTP + E F DVYL+T LMGADLN I++ Q
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 406 ELLNEHVQFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
+L ++HVQFL+YQILRGLKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 178
>sp|Q95NE7|MK14_PANTR Mitogen-activated protein kinase 14 (Mitogen-activated protein
kinase p38 alpha) (MAP kinase p38 alpha)
(Stress-activated protein kinase 2a)
Length = 360
Score = 241 bits (615), Expect = 1e-63
Identities = 113/178 (63%), Positives = 142/178 (79%)
Frame = +1
Query: 46 ISDNMSEFQLHNIAHSDWNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFH 225
+S F + + W VP RY+NL+P+G GAYGSVCAAFD K +VA+KKL+RPF
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 226 SPEYAKRTYRELKIIHHMDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQ 405
S +AKRTYREL+++ HM HEN++ L+D FTP + E F DVYL+T LMGADLN I++ Q
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 406 ELLNEHVQFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
+L ++HVQFL+YQILRGLKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 178
>sp|O02812|MK14_CANFA Mitogen-activated protein kinase 14 (Mitogen-activated protein
kinase p38 alpha) (MAP kinase p38 alpha)
Length = 360
Score = 241 bits (615), Expect = 1e-63
Identities = 113/178 (63%), Positives = 142/178 (79%)
Frame = +1
Query: 46 ISDNMSEFQLHNIAHSDWNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFH 225
+S F + + W VP RY+NL+P+G GAYGSVCAAFD K +VA+KKL+RPF
Sbjct: 1 MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ 60
Query: 226 SPEYAKRTYRELKIIHHMDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQ 405
S +AKRTYREL+++ HM HEN++ L+D FTP + E F DVYL+T LMGADLN I++ Q
Sbjct: 61 SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120
Query: 406 ELLNEHVQFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
+L ++HVQFL+YQILRGLKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 178
>sp|Q90336|MK14A_CYPCA Mitogen-activated protein kinase 14a (Mitogen-activated protein
kinase p38a) (MAP kinase p38a) (cp38a)
Length = 361
Score = 241 bits (615), Expect = 1e-63
Identities = 110/171 (64%), Positives = 141/171 (82%)
Frame = +1
Query: 67 FQLHNIAHSDWNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFHSPEYAKR 246
F + + W VP RY+NL+P+G GAYG+VC+A+D K +VA+KKL+RPF S +AKR
Sbjct: 9 FHRQEVNKTIWEVPVRYQNLSPVGSGAYGTVCSAYDEKTGLKVAVKKLSRPFQSIIHAKR 68
Query: 247 TYRELKIIHHMDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQELLNEHV 426
TYREL+++ HM HEN++ L+D FTP T+ E F DVYL+T LMGADLN I++ Q+L ++HV
Sbjct: 69 TYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 128
Query: 427 QFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
QFL+YQILRGLKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 129 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 179
>sp|Q9DGE2|MK14A_BRARE Mitogen-activated protein kinase 14a (Mitogen-activated protein
kinase p38a) (MAP kinase p38a) (zp38a)
Length = 361
Score = 238 bits (608), Expect = 6e-63
Identities = 110/171 (64%), Positives = 141/171 (82%)
Frame = +1
Query: 67 FQLHNIAHSDWNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFHSPEYAKR 246
F + + W VP +Y+NL+P+G GAYGSVC+AFD K +VA+KKL+RPF S +AKR
Sbjct: 9 FYRQEVNKTIWEVPVQYQNLSPVGSGAYGSVCSAFDAKTGFKVAVKKLSRPFQSIIHAKR 68
Query: 247 TYRELKIIHHMDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQELLNEHV 426
TYREL+++ HM HEN++ L+D FTP T+ + F DVYL+T LMGADLN I++ Q+L ++HV
Sbjct: 69 TYRELRLLKHMRHENVIGLLDVFTPATSLKEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 128
Query: 427 QFLVYQILRGLKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
QFL+YQILRGLKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 129 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE 179
>sp|Q9I958|MK14B_CYPCA Mitogen-activated protein kinase 14b (Mitogen-activated protein
kinase p38b) (MAP kinase p38b) (cp38b)
Length = 361
Score = 235 bits (599), Expect = 7e-62
Identities = 109/161 (67%), Positives = 136/161 (84%)
Frame = +1
Query: 97 WNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFHSPEYAKRTYRELKIIHH 276
W VP RY+NL+P+G GAYGSVC+A D K +VA+KKL+RPF S +AKRTYREL+++ H
Sbjct: 19 WEVPERYQNLSPVGSGAYGSVCSALDTKSGLRVAVKKLSRPFQSMIHAKRTYRELRLLKH 78
Query: 277 MDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQELLNEHVQFLVYQILRG 456
M HEN++ L+DAF+P T F DVYL+T LMGADLN I++ Q+L ++HVQFL+YQILRG
Sbjct: 79 MKHENVIGLLDAFSPATCLAGFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 138
Query: 457 LKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
LKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 139 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARLTDDE 179
>sp|P47812|MK14_XENLA Mitogen-activated protein kinase 14 (Mitogen-activated
Mitogen-activated protein kinase 2) (MAP kinase 2)
(MPK2)
Length = 361
Score = 234 bits (597), Expect = 1e-61
Identities = 107/161 (66%), Positives = 135/161 (83%)
Frame = +1
Query: 97 WNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFHSPEYAKRTYRELKIIHH 276
W VP RY+NL P+G GAYGSVC++FD + ++A+KKL+RPF S +AKRTYREL+++ H
Sbjct: 19 WEVPDRYQNLTPVGSGAYGSVCSSFDTRTALRIAVKKLSRPFQSIIHAKRTYRELRLLKH 78
Query: 277 MDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQELLNEHVQFLVYQILRG 456
M HEN++ L+D F+P + E F DVYL+T LMGADLN I++ Q+L ++HVQFL+YQILRG
Sbjct: 79 MKHENVIGLLDVFSPAKSFEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRG 138
Query: 457 LKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
LKY+HS+ IIHRDLKPSN+AVNEDCELKILDFGLAR TDEE
Sbjct: 139 LKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARHTDEE 179
>sp|Q9DGE1|MK14B_BRARE Mitogen-activated protein kinase 14b (Mitogen-activated protein
kinase p38b) (MAP kinase p38b) (zp38b)
Length = 348
Score = 233 bits (593), Expect = 4e-61
Identities = 108/161 (67%), Positives = 136/161 (84%)
Frame = +1
Query: 97 WNVPTRYENLNPIGHGAYGSVCAAFDHKLQRQVAIKKLARPFHSPEYAKRTYRELKIIHH 276
W VP RY+NL+P+G GAYGSV +AFD K +VA+KKL+RPF S +AKRTYREL+++ H
Sbjct: 19 WEVPERYQNLSPVGSGAYGSVMSAFDGKAGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 78
Query: 277 MDHENIVCLIDAFTPQTTRETFTDVYLITPLMGADLNAIIRTQELLNEHVQFLVYQILRG 456
M HEN++ L+D F+P T+ E F DVYL+T LMGADLN I++ Q+L ++HVQFL+YQILR
Sbjct: 79 MKHENVIGLLDVFSPATSLEGFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRA 138
Query: 457 LKYMHSSEIIHRDLKPSNIAVNEDCELKILDFGLARQTDEE 579
LKY+HS++IIHRDLKPSN+AVNEDCELKILDFGLAR TD+E
Sbjct: 139 LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARLTDDE 179
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,951,123
Number of Sequences: 369166
Number of extensions: 1293491
Number of successful extensions: 6021
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4984
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5155
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4504118060
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)