Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_M17
(692 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 211 2e-54
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 205 1e-52
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 202 7e-52
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 200 3e-51
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 196 5e-50
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 192 5e-49
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 192 7e-49
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 192 9e-49
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 191 2e-48
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 191 2e-48
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 211 bits (536), Expect = 2e-54
Identities = 101/211 (47%), Positives = 133/211 (63%)
Frame = +2
Query: 56 WETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEF 235
W +K + ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 236 KAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGS 415
KAKYL M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG+
Sbjct: 81 KAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGT 140
Query: 416 LEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQGIESEGDYPYTAT 595
+EGQY + ISFSEQQLVDCS LM+NA++Y+K G+E+E YPYTA
Sbjct: 141 MEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAV 200
Query: 596 DGTCKRNPSKIVTKCTGFTDIQSQNETDLAN 688
+G C+ N V K TG+ + S +E +L N
Sbjct: 201 EGQCRYNKQLGVAKVTGYYTVHSGSEVELKN 231
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 205 bits (521), Expect = 1e-52
Identities = 104/211 (49%), Positives = 131/211 (62%), Gaps = 1/211 (0%)
Frame = +2
Query: 44 LNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMT 223
L +W +K R Y + RR +WE+N+K I+ HN EY GKH++++ +N F DMT
Sbjct: 25 LEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMT 84
Query: 224 NEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFS 403
+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ QCGSCW+FS
Sbjct: 85 SEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFS 142
Query: 404 ATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDY 580
ATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G++SE Y
Sbjct: 143 ATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESY 202
Query: 581 PYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 673
PY AT+ +CK NP V TGF DI Q +
Sbjct: 203 PYEATEESCKYNPKYSVANDTGFVDIPKQEK 233
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 202 bits (514), Expect = 7e-52
Identities = 107/229 (46%), Positives = 140/229 (61%), Gaps = 1/229 (0%)
Frame = +2
Query: 8 TAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHT 187
+AVP KF N L+ +W +K T R Y + RR +WE+N+K I+ HN EY GKH
Sbjct: 16 SAVP-KFDQN--LDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHG 72
Query: 188 YSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVK 367
+++ +N F DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVK
Sbjct: 73 FTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVK 130
Query: 368 NQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI 547
NQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+
Sbjct: 131 NQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYV 190
Query: 548 KDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANA 691
K+ G++SE YPY A D CK P V TGFT + E L A
Sbjct: 191 KENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKA 239
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 200 bits (509), Expect = 3e-51
Identities = 105/225 (46%), Positives = 133/225 (59%), Gaps = 2/225 (0%)
Frame = +2
Query: 5 ITAVPQKFSVNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKH 184
I + KF + LN +W +K T R Y + RR +WE+N+K I+ HN EY GKH
Sbjct: 14 IASAAPKF--DQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKH 71
Query: 185 TYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPV 364
+++ +N F DMTNEEF+ G K +G + P +P SVDWR+KGYVTPV
Sbjct: 72 GFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWREKGYVTPV 129
Query: 365 KNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRY 544
KNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY
Sbjct: 130 KNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRY 189
Query: 545 IKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNE 673
+KD G++SE YPY D TC P TGF D+ + +
Sbjct: 190 VKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQREK 234
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 196 bits (498), Expect = 5e-50
Identities = 103/216 (47%), Positives = 128/216 (59%), Gaps = 2/216 (0%)
Frame = +2
Query: 32 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 211
++ L+ W +K T R Y + RR +WE+N K I HN EY GKH + + +N F
Sbjct: 21 LDPNLDAHWHQWKATHRRLYGMNEEEWRRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAF 80
Query: 212 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 391
DMTNEEF+ G K +G + P + V P SVDW +KGYVTPVKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSC 138
Query: 392 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 568
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDS 198
Query: 569 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNE 673
E YPY ATD +C P TGF DI + +
Sbjct: 199 EESYPYLATDTNSCNYKPECSAANDTGFVDIPQREK 234
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 192 bits (489), Expect = 5e-49
Identities = 102/208 (49%), Positives = 127/208 (61%), Gaps = 1/208 (0%)
Frame = +2
Query: 53 EWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEE 232
EW +K+T R Y + RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEE
Sbjct: 28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEE 87
Query: 233 FKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATG 412
F+ G K +G + P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G
Sbjct: 88 FRQVVNGYRHQKHK-KGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASG 145
Query: 413 SLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYT 589
LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YPY
Sbjct: 146 CLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYE 205
Query: 590 ATDGTCKRNPSKIVTKCTGFTDIQSQNE 673
A DG+CK V TGF DI Q +
Sbjct: 206 AKDGSCKYRAEFAVANDTGFVDIPQQEK 233
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 192 bits (488), Expect = 7e-49
Identities = 100/210 (47%), Positives = 128/210 (60%), Gaps = 1/210 (0%)
Frame = +2
Query: 47 NEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTN 226
N +W +K+T R Y + RR +WE+N++ IQ HN EY GKH +++ +N F DMTN
Sbjct: 26 NAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTN 85
Query: 227 EEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSA 406
EEF+ G K +G + P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA
Sbjct: 86 EEFRQIVNGYRHQKHK-KGRLFQEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSA 143
Query: 407 TGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYP 583
+G LEGQ F K +LIS SEQ LVDCS LMD AF+YIK+ G++SE YP
Sbjct: 144 SGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYP 203
Query: 584 YTATDGTCKRNPSKIVTKCTGFTDIQSQNE 673
Y A DG+CK V TGF DI Q +
Sbjct: 204 YEAKDGSCKYRAEYAVANDTGFVDIPQQEK 233
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 192 bits (487), Expect = 9e-49
Identities = 99/216 (45%), Positives = 130/216 (60%), Gaps = 2/216 (0%)
Frame = +2
Query: 32 VNSELNEEWETYKTTFGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQF 211
++ L+ +W +K T GR Y + RR +WE+N+K I+ HN EY GKH +S+ +N F
Sbjct: 21 LDQNLDADWYKWKATHGRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAF 80
Query: 212 ADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSC 391
DMTNEEF+ G K +G + + V P SVDWR+KGYVT VKNQ QCGSC
Sbjct: 81 GDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQGQCGSC 138
Query: 392 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIES 568
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD G+++
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDT 198
Query: 569 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNE 673
E YPY + +C P TGF DI + +
Sbjct: 199 EESYPYLGRETNSCTYKPECSAANDTGFVDIPQREK 234
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 191 bits (484), Expect = 2e-48
Identities = 101/220 (45%), Positives = 136/220 (61%), Gaps = 4/220 (1%)
Frame = +2
Query: 44 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 220
L+ +WE +K T+ ++Y+ D I+RRLIWE+NLK+I HNLE LG HTY L +N DM
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 221 TNEEFKAKYLGIMKTKPTLEGS--TYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCW 394
T+EE K G+ K P+ S T P+ G P S+D+R+KGYVTPVKNQ QCGSCW
Sbjct: 82 TSEEVVQKMTGL-KVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCW 140
Query: 395 SFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI-KDQGIESE 571
+FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+ +++GI+SE
Sbjct: 141 AFSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENYGCGGGYMTNAFQYVQRNRGIDSE 198
Query: 572 GDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANA 691
YPY D +C NP+ KC G+ +I NE L A
Sbjct: 199 DAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRA 238
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 191 bits (484), Expect = 2e-48
Identities = 101/219 (46%), Positives = 132/219 (60%), Gaps = 3/219 (1%)
Frame = +2
Query: 44 LNEEWETYKTTFGRKYDELTD-ITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADM 220
L+ WE +K T ++Y+ D I+RRLIWE+NLKYI HNLE LG HTY L +N DM
Sbjct: 22 LDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 221 TNEEFKAKYLGI-MKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWS 397
TNEE K G+ + + T P+ G P SVD+R+KGYVTPVKNQ QCGSCW+
Sbjct: 82 TNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 398 FSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI-KDQGIESEG 574
FS+ G+LEGQ +K +L++ S Q LVDC M NAF+Y+ K++GI+SE
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDC--VSENDGCGGGYMTNAFQYVQKNRGIDSED 199
Query: 575 DYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANA 691
YPY + +C NP+ KC G+ +I NE L A
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRA 238
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,863,288
Number of Sequences: 369166
Number of extensions: 1425840
Number of successful extensions: 4065
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3700
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3806
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5976365205
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)