Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_M05
(779 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q07994|NCPR_MUSDO NADPH--cytochrome P450 reductase (CPR)... 333 3e-91
sp|P00389|NCPR_RABIT NADPH--cytochrome P450 reductase (CPR)... 333 4e-91
sp|P16435|NCPR_HUMAN NADPH--cytochrome P450 reductase (CPR)... 332 7e-91
sp|P37039|NCPR_CAVPO NADPH--cytochrome P450 reductase (CPR)... 330 3e-90
sp|P04175|NCPR_PIG NADPH--cytochrome P450 reductase (CPR) (... 326 4e-89
sp|P37040|NCPR_MOUSE NADPH--cytochrome P450 reductase (CPR)... 325 9e-89
sp|P00388|NCPR_RAT NADPH--cytochrome P450 reductase (CPR) (... 325 1e-88
sp|Q27597|NCPR_DROME NADPH--cytochrome P450 reductase (CPR)... 324 2e-88
sp||P19618_1 [Segment 1 of 3] NADPH--cytochrome P450 reduct... 323 3e-88
sp|Q9HDG2|NCPR_PHACH NADPH--cytochrome P450 reductase (CPR)... 169 6e-42
>sp|Q07994|NCPR_MUSDO NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 671
Score = 333 bits (854), Expect = 3e-91
Identities = 153/258 (59%), Positives = 196/258 (75%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNA EFY WI N DL+GL Y VFGLGNKTYE++N + Y D+RL ELGATR+
Sbjct: 138 GEGDPTDNAMEFYEWITNGEVDLTGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGATRV 197
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
ELG+GDDD+NIED FITWK+ W SVC+ FGI G +V MRQ+RLL DV ++IY
Sbjct: 198 FELGLGDDDANIEDDFITWKDRFWPSVCDFFGIEGSGEEVLMRQFRLLEQPDVQPDRIYT 257
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL + + QRPP+DAKNPFL+ V+V + L KGG R+ MHIE DI S+++YD+GDH+
Sbjct: 258 GEIARLHSMQNQRPPFDAKNPFLASVIVNRELHKGGGRSCMHIELDIDGSKMRYDAGDHI 317
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
A++P ND ILV+KL K + NLD V S++ D D+SK+HPFPCPTTYRTAL HY++I
Sbjct: 318 AMYPINDKILVEKLGKLCDANLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAI 377
Query: 722 LKTNVLGELSEYASDKSE 775
+T++L EL+EY SD+ +
Sbjct: 378 PRTHILKELAEYCSDEKD 395
>sp|P00389|NCPR_RABIT NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 679
Score = 333 bits (853), Expect = 4e-91
Identities = 148/258 (57%), Positives = 207/258 (80%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNAQ+FY+W+Q T+ DLSG++Y VFGLGNKTYE+FNAMGKY D+RL +LGA RI
Sbjct: 142 GEGDPTDNAQDFYDWLQETDVDLSGVKYAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRI 201
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
ELG+GDDD+N+E+ FITW+E W +VC FG+ + ++RQY L+L TD+ K+Y+
Sbjct: 202 FELGMGDDDANLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVLHTDIDVAKVYQ 261
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL ++E Q+PP+DAKNPFL+ V + L +G +R +MH+E DI++S+I+Y+SGDHV
Sbjct: 262 GEMGRLKSYENQKPPFDAKNPFLATVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHV 321
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
AV+P ND LV++L + L +LD V+S+ +DE+++K+HPFPCPT+YRTAL +Y+DI NP
Sbjct: 322 AVYPANDSALVNQLGEILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNP 381
Query: 722 LKTNVLGELSEYASDKSE 775
+TNVL EL++YA+D +E
Sbjct: 382 PRTNVLYELAQYAADPAE 399
>sp|P16435|NCPR_HUMAN NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 677
Score = 332 bits (851), Expect = 7e-91
Identities = 148/258 (57%), Positives = 205/258 (79%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNAQ+FY+W+Q T+ DLSG+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI
Sbjct: 141 GEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRI 200
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
ELG+GDDD N+E+ FITW+E W +VC FG+ + ++RQY L++ TD+ K+Y
Sbjct: 201 FELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYM 260
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL ++E Q+PP+DAKNPFL+ V + L +G +R +MH+E DI++S+I+Y+SGDHV
Sbjct: 261 GEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHV 320
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
AV+P ND LV++L K L +LD V+S+ +DE+++K+HPFPCPT+YRTAL +Y+DI NP
Sbjct: 321 AVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNP 380
Query: 722 LKTNVLGELSEYASDKSE 775
+TNVL EL++YAS+ SE
Sbjct: 381 PRTNVLYELAQYASEPSE 398
>sp|P37039|NCPR_CAVPO NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 678
Score = 330 bits (845), Expect = 3e-90
Identities = 149/258 (57%), Positives = 203/258 (78%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNAQ+FY+W+Q T+ DLSG++Y VFGLGNKTYE+FN+MGKY D+RL +LGA RI
Sbjct: 141 GEGDPTDNAQDFYDWLQETDLDLSGVKYAVFGLGNKTYEHFNSMGKYVDQRLEQLGAQRI 200
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
ELG+GDDD N+E+ FITW+E W +VC FG+ + ++RQY L+L D K+Y
Sbjct: 201 FELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVLHADTDPAKVYT 260
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL ++E Q+PP+DAKNPFL+ V + L +G +R +MH+E DI++S+I+Y+SGDHV
Sbjct: 261 GEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHV 320
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
AV+P ND LV++L K L +LD V+S+ +DE+++K+HPFPCPTTYRTAL +Y+DI NP
Sbjct: 321 AVYPANDSNLVNQLGKILGADLDVVMSLKNLDEESNKKHPFPCPTTYRTALTYYLDITNP 380
Query: 722 LKTNVLGELSEYASDKSE 775
+TNVL EL++YAS+ SE
Sbjct: 381 PRTNVLYELAQYASEPSE 398
>sp|P04175|NCPR_PIG NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 678
Score = 326 bits (836), Expect = 4e-89
Identities = 146/258 (56%), Positives = 203/258 (78%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNAQ+FY+W+Q + DL+G++Y VFGLGNKTYE+FNAMGKY D+RL +LGA RI
Sbjct: 141 GEGDPTDNAQDFYDWLQEADVDLTGVKYAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRI 200
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
+LG+GDDD N+E+ FITW+E W +VC FG+ + ++RQY L++ TD+ +Y
Sbjct: 201 FDLGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDMDTAVVYT 260
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL ++E Q+PP+DAKNPFL+ V + L +G +R +MH+E DI++S+I+Y+SGDHV
Sbjct: 261 GEMGRLKSYENQKPPFDAKNPFLAVVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHV 320
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
AV+P ND LV++L + L +LD V+S+ +DE+++KRHPFPCPTTYRTAL +Y+DI NP
Sbjct: 321 AVYPANDSALVNQLGEILGTDLDIVMSLNNLDEESNKRHPFPCPTTYRTALTYYLDITNP 380
Query: 722 LKTNVLGELSEYASDKSE 775
+TNVL EL++YAS+ SE
Sbjct: 381 PRTNVLYELAQYASEPSE 398
>sp|P37040|NCPR_MOUSE NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 678
Score = 325 bits (833), Expect = 9e-89
Identities = 144/258 (55%), Positives = 204/258 (79%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNAQ+FY+W+Q T+ DL+G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI
Sbjct: 141 GEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRI 200
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
ELG+GDDD N+E+ FITW+E W +VC FG+ + ++RQY L++ D+ K+Y
Sbjct: 201 FELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDTAKVYT 260
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL ++E Q+PP+DAKNPFL+ V + L +G +R +MH+E DI++S+I+Y+SGDHV
Sbjct: 261 GEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHV 320
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
AV+P ND LV+++ + L +LD ++S+ +DE+++K+HPFPCPTTYRTAL +Y+DI NP
Sbjct: 321 AVYPANDSTLVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNP 380
Query: 722 LKTNVLGELSEYASDKSE 775
+TNVL EL++YAS+ SE
Sbjct: 381 PRTNVLYELAQYASEPSE 398
>sp|P00388|NCPR_RAT NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 678
Score = 325 bits (832), Expect = 1e-88
Identities = 144/258 (55%), Positives = 204/258 (79%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNAQ+FY+W+Q T+ DL+G+++ VFGLGNKTYE+FNAMGKY D+RL +LGA RI
Sbjct: 141 GEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRI 200
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
ELG+GDDD N+E+ FITW+E W +VC FG+ + ++RQY L++ D+ K+Y
Sbjct: 201 FELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDVAKVYT 260
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL ++E Q+PP+DAKNPFL+ V + L +G +R +MH+E DI++S+I+Y+SGDHV
Sbjct: 261 GEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHV 320
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
AV+P ND LV+++ + L +LD ++S+ +DE+++K+HPFPCPTTYRTAL +Y+DI NP
Sbjct: 321 AVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNP 380
Query: 722 LKTNVLGELSEYASDKSE 775
+TNVL EL++YAS+ SE
Sbjct: 381 PRTNVLYELAQYASEPSE 398
>sp|Q27597|NCPR_DROME NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 679
Score = 324 bits (830), Expect = 2e-88
Identities = 149/258 (57%), Positives = 193/258 (74%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNA EFY WI + + DLSGL Y VFGLGNKTYE++N + Y D+RL ELGA R+
Sbjct: 145 GEGDPTDNAMEFYEWITSGDVDLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRV 204
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
ELG+GDDD+NIED FITWK+ W +VC+ FGI G +V +RQYRLL DV ++IY
Sbjct: 205 FELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLEQPDVQPDRIYT 264
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL + + QRPP+DAKNPFL+ + V + L KGG R+ MHIE I S+++YD+GDHV
Sbjct: 265 GEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHV 324
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
A+FP ND LV+KL + N +LD V S++ D D+SK+HPFPCPTTYRTAL HY++I
Sbjct: 325 AMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAI 384
Query: 722 LKTNVLGELSEYASDKSE 775
+T++L EL+EY +D+ E
Sbjct: 385 PRTHILKELAEYCTDEKE 402
>sp||P19618_1 [Segment 1 of 3] NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 426
Score = 323 bits (828), Expect = 3e-88
Identities = 143/255 (56%), Positives = 198/255 (77%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLSGLRYTVFGLGNKTYENFNAMGKYFDRRLAELGATRI 181
GEGDPTDNAQ+FY+W+Q T+ LSG+ Y VF LG+KTYE++NAMG Y D+RL ELGA R+
Sbjct: 86 GEGDPTDNAQDFYDWLQETDGQLSGVNYPVFALGDKTYEHYNAMGAYVDKRLEELGAKRV 145
Query: 182 HELGVGDDDSNIEDHFITWKEDMWTSVCNQFGISGDKIDVNMRQYRLLLPTDVAENKIYK 361
+LG+GDDD N+E+ F+TW+E W ++C FG+ D ++RQY L D+ NK+Y
Sbjct: 146 FDLGMGDDDGNLEEDFVTWREQFWPAMCEHFGVEASGEDSSVRQYELKEHNDINMNKVYT 205
Query: 362 GEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNLCKGGDRTVMHIEFDITNSRIKYDSGDHV 541
GE+ RL +FE Q+PP+DAKNPFL+ V V + L K G+ MH+E DIT S+I+Y+SGDHV
Sbjct: 206 GELGRLKSFETQKPPFDAKNPFLAPVTVNRKLNKAGELHKMHLEVDITGSKIRYESGDHV 265
Query: 542 AVFPTNDPILVDKLAKRLNINLDQVISMVAVDEDNSKRHPFPCPTTYRTALLHYIDINNP 721
AV+PTN+ ++V++L + L ++LD VIS+ +DE+++K+HPFPCPTTYRTAL HY+DI +P
Sbjct: 266 AVYPTNNTVIVNRLGQILGVDLDSVISLNNLDEESNKKHPFPCPTTYRTALTHYLDIIHP 325
Query: 722 LKTNVLGELSEYASD 766
+TNVL EL++YA+D
Sbjct: 326 PRTNVLYELAQYATD 340
>sp|Q9HDG2|NCPR_PHACH NADPH--cytochrome P450 reductase (CPR) (P450R)
Length = 736
Score = 169 bits (429), Expect = 6e-42
Identities = 101/267 (37%), Positives = 152/267 (56%), Gaps = 14/267 (5%)
Frame = +2
Query: 2 GEGDPTDNAQEFYNWIQNTNADLS-------GLRYTVFGLGNKTYENFNAMGKYFDRRLA 160
GEG+PTDNA + + + + + S GL+Y +FGLGNKTYE++N + + DR L
Sbjct: 126 GEGEPTDNAVQLCQNLSDESFEFSNGEHKLPGLKYVIFGLGNKTYEHYNLISRNVDRDLQ 185
Query: 161 ELGATRIHELGVGDDDSNIEDHFITWKEDMWTSVCN----QFGISGDKIDVNMRQYRLLL 328
++GA RI E G GDDD ++E+ ++ WK+ MW + + G GD D + +
Sbjct: 186 KMGAIRIGERGEGDDDKSMEEDYLEWKDGMWEAFAKAMNVEEGQGGDSPDFVVTEV---- 241
Query: 329 PTDVAENKIYKGEVTRLGAFEKQRPPYDAKNPFLSKVLVKKNL-CKGGDRTVMHIEFDIT 505
D E K+Y GE++ A + + +DAKNP+ + ++ K L G DR +HIE
Sbjct: 242 -FDHPEEKVYLGELS-ARALTRTKGIHDAKNPYPAPIIAAKELFAPGSDRNCVHIELSTE 299
Query: 506 NSRIKYDSGDHVAVFPTNDPILVDKLAKRLNIN--LDQVISMVAVDEDNSKRHPFPCPTT 679
+S I Y GDHV V+P+N VD+L L ++ D VI++ ++D +K PFP PTT
Sbjct: 300 SSGITYQHGDHVGVWPSNADKEVDRLLYALGLHEKKDTVINIESLDPALAK-VPFPVPTT 358
Query: 680 YRTALLHYIDINNPLKTNVLGELSEYA 760
Y T L HYIDI+ +LG L+++A
Sbjct: 359 YATVLRHYIDISALAGRQILGVLAKFA 385
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,050,431
Number of Sequences: 369166
Number of extensions: 1908763
Number of successful extensions: 4713
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4519
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4654
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7308943600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)