Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_K21
(723 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 215 8e-56
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 211 1e-54
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 208 1e-53
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 207 2e-53
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 202 6e-52
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 202 1e-51
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 198 1e-50
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 196 5e-50
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 195 9e-50
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 195 1e-49
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 215 bits (548), Expect = 8e-56
Identities = 103/170 (60%), Positives = 127/170 (74%), Gaps = 3/170 (1%)
Frame = +3
Query: 69 KQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQDGDCEYSKEKVVAHC 245
+Q LVDCS+D GNQGCNGGLMD AFQYI + G L+ E YPY A+DG C+Y E VA+
Sbjct: 163 EQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVAND 222
Query: 246 QGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDEENCSSTQLDHGVLAV 425
GF DI E+ L + +ATVGPISV +DAS+PS QFY G+Y E NCSS LDHGVL V
Sbjct: 223 TGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVV 281
Query: 426 GYGND--EDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 569
GYG + + ++ YWLVKNSWGK WG++GYIK++KD++N CG+AT ASYP
Sbjct: 282 GYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYP 331
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 211 bits (538), Expect = 1e-54
Identities = 105/170 (61%), Positives = 125/170 (73%), Gaps = 3/170 (1%)
Frame = +3
Query: 69 KQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQDGDCEYSKEKVVAHC 245
+Q LVDCS+ GNQGCNGGLMD AFQYI + G L+ E YPY A+DG C+Y E VA+
Sbjct: 163 EQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVAND 222
Query: 246 QGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDEENCSSTQLDHGVLAV 425
GF DI E+ L + +ATVGPISV +DAS+PS QFY G+Y E NCSS LDHGVL V
Sbjct: 223 TGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLV 281
Query: 426 GYGND-EDSQQN-YWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 569
GYG + DS +N YWLVKNSWG WG+ GYIK++KD+DN CG+AT ASYP
Sbjct: 282 GYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYP 331
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 208 bits (530), Expect = 1e-53
Identities = 98/168 (58%), Positives = 124/168 (73%), Gaps = 1/168 (0%)
Frame = +3
Query: 69 KQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQDGDCEYSKEKVVAHC 245
+Q LVDCS +GN GCNGGLMD+AF+YI G ++ E YPY A D C ++K V A
Sbjct: 173 EQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATD 232
Query: 246 QGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDEENCSSTQLDHGVLAV 425
+GFTDI G E+ +AE +ATVGP+SV IDAS+ SFQFY GVY+E C + LDHGVL V
Sbjct: 233 RGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVV 292
Query: 426 GYGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 569
G+G DE S ++YWLVKNSWG +WG G+IKM ++K+NQCGIA+ +SYP
Sbjct: 293 GFGTDE-SGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYP 339
Score = 31.2 bits (69), Expect = 2.9
Identities = 13/23 (56%), Positives = 19/23 (82%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FS+TG++EGQ+F+ + LVS SE
Sbjct: 151 FSSTGALEGQHFRKSGVLVSLSE 173
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 207 bits (528), Expect = 2e-53
Identities = 101/187 (54%), Positives = 127/187 (67%), Gaps = 3/187 (1%)
Frame = +3
Query: 24 KGNILKIISS*LVFQKQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQ 200
+G + + + +Q LVDCS GNQGCNGG M AFQY+ + G L+ E YPY A
Sbjct: 148 EGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAV 207
Query: 201 DGDCEYSKEKVVAHCQGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDE 380
D C+Y E VA+ GFT ++ G E+ L + +ATVGPISV +DA + SFQFYK G+Y E
Sbjct: 208 DEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFE 267
Query: 381 ENCSSTQLDHGVLAVGYGNDEDSQQN--YWLVKNSWGKSWGINGYIKMSKDKDNQCGIAT 554
+CSS LDHGVL VGYG + + N YWLVKNSWG WG NGY+K++KDK+N CGIAT
Sbjct: 268 PDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIAT 327
Query: 555 MASYPNM 575
ASYPN+
Sbjct: 328 AASYPNV 334
Score = 30.4 bits (67), Expect = 5.0
Identities = 13/23 (56%), Positives = 17/23 (73%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FS TG++EGQ F+ +LVS SE
Sbjct: 141 FSATGALEGQMFRKTGKLVSLSE 163
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 202 bits (515), Expect = 6e-52
Identities = 99/170 (58%), Positives = 121/170 (71%), Gaps = 1/170 (0%)
Frame = +3
Query: 69 KQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQDGDCEYSKEKVVAHC 245
+QQLVDCS D+GN GC GG M SAF YI G ++ ES YPY A+D C + + A C
Sbjct: 155 EQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDTESSYPYEAEDRSCRFDANSIGAIC 214
Query: 246 QGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDEENCSSTQLDHGVLAV 425
G ++ H +EE L E ++ VGPISV IDAS+ SFQFY GVY E+NCS T LDHGVLAV
Sbjct: 215 TGSVEVQH-TEEALQEAVSGVGPISVAIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAV 273
Query: 426 GYGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 575
GYG +S ++YWLVKNSWG SWG GYIKMS+++DN CGIA+ SYP +
Sbjct: 274 GYGT--ESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSYPTV 321
Score = 33.1 bits (74), Expect = 0.77
Identities = 14/23 (60%), Positives = 18/23 (78%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FS TG++EGQ+F N +LVS SE
Sbjct: 133 FSATGALEGQHFLKNDELVSLSE 155
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 202 bits (513), Expect = 1e-51
Identities = 94/170 (55%), Positives = 119/170 (70%), Gaps = 1/170 (0%)
Frame = +3
Query: 69 KQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQDGDCEYSKEKVVAHC 245
+Q LVDCS +GN GCNGGLMD+AF+YI G ++ E YPY D C ++K + A
Sbjct: 171 EQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATD 230
Query: 246 QGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDEENCSSTQLDHGVLAV 425
GF DI G EE + + +AT+GP+SV IDAS+ SFQ Y GVY+E C LDHGVL V
Sbjct: 231 TGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVV 290
Query: 426 GYGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYPNM 575
GYG DE S +YWLVKNSWG +WG GYIKM+++++NQCGIAT +SYP +
Sbjct: 291 GYGTDE-SGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASSYPTV 339
Score = 30.0 bits (66), Expect = 6.5
Identities = 13/23 (56%), Positives = 18/23 (78%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FS+TG++EGQ+F+ LVS SE
Sbjct: 149 FSSTGALEGQHFRKAGVLVSLSE 171
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 198 bits (504), Expect = 1e-50
Identities = 94/168 (55%), Positives = 120/168 (71%), Gaps = 1/168 (0%)
Frame = +3
Query: 69 KQQLVDCSNDFGNQGCNGGLMDSAFQYIM-QYGLEKESDYPYTAQDGDCEYSKEKVVAHC 245
+QQLVDCS +G QGCNGG M+ AF YI G++ E+ YPY A+DG C + V A C
Sbjct: 156 EQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATC 215
Query: 246 QGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDEENCSSTQLDHGVLAV 425
G T+I+ GSE L + + +GPISV IDA++ SFQFY GVY E +CS + LDH VLAV
Sbjct: 216 SGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAV 275
Query: 426 GYGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMASYP 569
GYG+ + Q++WLVKNSW SWG GYIKMS++++N CGIAT+ASYP
Sbjct: 276 GYGS--EGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYP 321
Score = 31.2 bits (69), Expect = 2.9
Identities = 13/23 (56%), Positives = 17/23 (73%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FSTTGS+EGQ+F L+S +E
Sbjct: 134 FSTTGSLEGQHFLKTGSLISLAE 156
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 196 bits (498), Expect = 5e-50
Identities = 96/187 (51%), Positives = 124/187 (66%), Gaps = 3/187 (1%)
Frame = +3
Query: 24 KGNILKIISS*LVFQKQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQ 200
+G + + + +Q LVDCS GN+GCNGGLMD AFQY+ G L+ E YPY A
Sbjct: 148 EGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEAT 207
Query: 201 DGDCEYSKEKVVAHCQGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDE 380
+ C+Y+ + VA+ GF DI E+ L + +ATVGPISV IDA + SF FYK G+Y E
Sbjct: 208 EESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFE 266
Query: 381 ENCSSTQLDHGVLAVGYG--NDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIAT 554
+CSS +DHGVL VGYG + E YWLVKNSWG+ WG+ GY+KM+KD+ N CGIA+
Sbjct: 267 PDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIAS 326
Query: 555 MASYPNM 575
ASYP +
Sbjct: 327 AASYPTV 333
Score = 30.0 bits (66), Expect = 6.5
Identities = 12/23 (52%), Positives = 17/23 (73%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FS TG++EGQ F+ +L+S SE
Sbjct: 141 FSATGALEGQMFRKTGRLISLSE 163
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 195 bits (496), Expect = 9e-50
Identities = 98/185 (52%), Positives = 121/185 (65%), Gaps = 1/185 (0%)
Frame = +3
Query: 24 KGNILKIISS*LVFQKQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQ 200
+G + + + +Q LVD S GNQGCNGGLMD+AFQYI + G L+ E YPY A
Sbjct: 35 EGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDSEESYPYEAT 94
Query: 201 DGDCEYSKEKVVAHCQGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYDE 380
D C Y E A GF DI E+ L + +ATVGPISV IDA + SFQFYK G+Y +
Sbjct: 95 DTSCNYKPEYSAAKDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYD 153
Query: 381 ENCSSTQLDHGVLAVGYGNDEDSQQNYWLVKNSWGKSWGINGYIKMSKDKDNQCGIATMA 560
+CSS LDHGVL VGYG E + +W+VKNSWG WG GY+KM+KD++N CGIAT A
Sbjct: 154 PDCSSKDLDHGVLVVGYG-FEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAA 212
Query: 561 SYPNM 575
SYP +
Sbjct: 213 SYPTV 217
Score = 30.4 bits (67), Expect = 5.0
Identities = 13/23 (56%), Positives = 17/23 (73%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FS TG++EGQ F+ +LVS SE
Sbjct: 28 FSATGALEGQMFRKTGKLVSLSE 50
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 195 bits (495), Expect = 1e-49
Identities = 101/188 (53%), Positives = 124/188 (65%), Gaps = 4/188 (2%)
Frame = +3
Query: 24 KGNILKIISS*LVFQKQQLVDCSNDFGNQGCNGGLMDSAFQYIMQYG-LEKESDYPYTAQ 200
+G + + + +Q LVDCS GNQGCNGGLMD+AFQYI G L+ E YPY A
Sbjct: 148 EGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLAT 207
Query: 201 D-GDCEYSKEKVVAHCQGFTDISHGSEEDLAEKLATVGPISVGIDASNPSFQFYKGGVYD 377
D C Y E A+ GF DI E+ L + +ATVGPISV IDA + SFQFYK G+Y
Sbjct: 208 DTNSCNYKPECSAANDTGFVDIPQ-REKALMKAVATVGPISVAIDAGHTSFQFYKSGIYY 266
Query: 378 EENCSSTQLDHGVLAVGYGND-EDSQQN-YWLVKNSWGKSWGINGYIKMSKDKDNQCGIA 551
+ +CS LDHGVL VGYG + DS N +W+VKNSWG WG NGY+KM+KD++N CGIA
Sbjct: 267 DPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIA 326
Query: 552 TMASYPNM 575
T ASYP +
Sbjct: 327 TAASYPTV 334
Score = 30.4 bits (67), Expect = 5.0
Identities = 13/23 (56%), Positives = 17/23 (73%)
Frame = +2
Query: 2 FSTTGSMEGQYFKNNKQLVSFSE 70
FS TG++EGQ F+ +LVS SE
Sbjct: 141 FSATGALEGQMFRKTGKLVSLSE 163
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,214,759
Number of Sequences: 369166
Number of extensions: 1744915
Number of successful extensions: 5137
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4459
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4684
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6462248555
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)