Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_J03
(788 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein ... 228 2e-59
sp|Q00438|PTBP1_RAT Polypyrimidine tract-binding protein 1 ... 225 1e-58
sp|Q8BHD7|ROD1_MOUSE Regulator of differentiation 1 (Rod1) 224 2e-58
sp|Q9Z118|ROD1_RAT Regulator of differentiation 1 (Rod1) 224 2e-58
sp|O95758|ROD1_HUMAN Regulator of differentiation 1 (Rod1) 224 3e-58
sp|Q29099|PTBP1_PIG Polypyrimidine tract-binding protein 1 ... 223 4e-58
sp|P17225|PTBP1_MOUSE Polypyrimidine tract-binding protein ... 196 6e-50
sp|Q8R081|HNRPL_MOUSE Heterogeneous nuclear ribonucleoprote... 82 2e-15
sp|P14866|HNRPL_HUMAN Heterogeneous nuclear ribonucleoprote... 80 5e-15
sp|Q8WVV9|HNRLL_HUMAN Heterogeneous nuclear ribonucleoprote... 75 2e-13
>sp|P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I) (57 kDa RNA-binding
protein PPTB-1)
Length = 531
Score = 228 bits (580), Expect = 2e-59
Identities = 113/196 (57%), Positives = 143/196 (72%), Gaps = 1/196 (0%)
Frame = +1
Query: 151 SGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRN 330
+GNSV+LV+NLN E+ P +LF LFGVYGDV RVK++FNKK ALVQ A+ QA A+ +
Sbjct: 334 AGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGNQAQLAMSH 393
Query: 331 LDACFLWGKQMHLHVSKTNVIQLPME-DANHGLTKDYSNSTLHRFKKPNSKNYQNIFPPS 507
L+ L GK + + +SK +QLP E + GLTKDY NS LHRFKKP SKN+QNIFPPS
Sbjct: 394 LNGHKLHGKPIRITLSKHQNVQLpreGQEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPS 453
Query: 508 AVLHLSNIPPTTGEGDLSEMIRSSGFEIKKFKFLPNDKKMALLELNSVEDAIHVLIDFHN 687
A LHLSNIPP+ E DL + S+G +K FKF D+KMAL+++ SVE+A+ LID HN
Sbjct: 454 ATLHLSNIPPSVSEEDLKVLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIDLHN 513
Query: 688 HKLSEKNHLRISFSKA 735
H L E +HLR+SFSK+
Sbjct: 514 HDLGENHHLRVSFSKS 529
>sp|Q00438|PTBP1_RAT Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I) (Pyrimidine-binding
protein) (PYBP)
Length = 555
Score = 225 bits (573), Expect = 1e-58
Identities = 110/196 (56%), Positives = 143/196 (72%), Gaps = 1/196 (0%)
Frame = +1
Query: 151 SGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRN 330
+GNSV+LV+NLN E+ P +LF LFGVYGDV RVK++FNKK ALV+ A+ QA A+ +
Sbjct: 358 AGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVEMADGSQAQLAMSH 417
Query: 331 LDACFLWGKQMHLHVSKTNVIQLPME-DANHGLTKDYSNSTLHRFKKPNSKNYQNIFPPS 507
L+ L GK + + +SK +QLP E + GLTKDY +S LHRFKKP SKN+QNIFPPS
Sbjct: 418 LNGHKLHGKSVRITLSKHQSVQLpreGQEDQGLTKDYGSSPLHRFKKPGSKNFQNIFPPS 477
Query: 508 AVLHLSNIPPTTGEGDLSEMIRSSGFEIKKFKFLPNDKKMALLELNSVEDAIHVLIDFHN 687
A LHLSNIPP+ E DL + S+G +K FKF D+KMAL+++ SVE+A+ LI+ HN
Sbjct: 478 ATLHLSNIPPSVSEDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHN 537
Query: 688 HKLSEKNHLRISFSKA 735
H L E +HLR+SFSK+
Sbjct: 538 HDLGENHHLRVSFSKS 553
>sp|Q8BHD7|ROD1_MOUSE Regulator of differentiation 1 (Rod1)
Length = 523
Score = 224 bits (571), Expect = 2e-58
Identities = 113/195 (57%), Positives = 138/195 (70%), Gaps = 1/195 (0%)
Frame = +1
Query: 154 GNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRNL 333
GNSV+LVTNLN + P LF LFGVYGDV RVK+MFNKK ALVQ A+ QA A+ +L
Sbjct: 327 GNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQLAMNHL 386
Query: 334 DACFLWGKQMHLHVSKTNVIQLPME-DANHGLTKDYSNSTLHRFKKPNSKNYQNIFPPSA 510
L+GK + +SK +QLP E + GLTKD+SNS LHRFKKP SKN+QNIFPPSA
Sbjct: 387 SGQRLYGKVLRATLSKHQAVQLpreGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSA 446
Query: 511 VLHLSNIPPTTGEGDLSEMIRSSGFEIKKFKFLPNDKKMALLELNSVEDAIHVLIDFHNH 690
LHLSNIPP+ DL + +G +K FKF D+KMAL++L SVE+AI LI+ HNH
Sbjct: 447 TLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNH 506
Query: 691 KLSEKNHLRISFSKA 735
L E +HLR+SFSK+
Sbjct: 507 DLGENHHLRVSFSKS 521
>sp|Q9Z118|ROD1_RAT Regulator of differentiation 1 (Rod1)
Length = 523
Score = 224 bits (571), Expect = 2e-58
Identities = 113/195 (57%), Positives = 138/195 (70%), Gaps = 1/195 (0%)
Frame = +1
Query: 154 GNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRNL 333
GNSV+LVTNLN + P LF LFGVYGDV RVK+MFNKK ALVQ A+ QA A+ +L
Sbjct: 327 GNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQAQIAMNHL 386
Query: 334 DACFLWGKQMHLHVSKTNVIQLPME-DANHGLTKDYSNSTLHRFKKPNSKNYQNIFPPSA 510
L+GK + +SK +QLP E + GLTKD+SNS LHRFKKP SKN+QNIFPPSA
Sbjct: 387 SGQRLYGKVLRATLSKHQAVQLpreGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSA 446
Query: 511 VLHLSNIPPTTGEGDLSEMIRSSGFEIKKFKFLPNDKKMALLELNSVEDAIHVLIDFHNH 690
LHLSNIPP+ DL + +G +K FKF D+KMAL++L SVE+AI LI+ HNH
Sbjct: 447 TLHLSNIPPSVTMDDLKNLFTEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNH 506
Query: 691 KLSEKNHLRISFSKA 735
L E +HLR+SFSK+
Sbjct: 507 DLGENHHLRVSFSKS 521
>sp|O95758|ROD1_HUMAN Regulator of differentiation 1 (Rod1)
Length = 521
Score = 224 bits (570), Expect = 3e-58
Identities = 113/195 (57%), Positives = 138/195 (70%), Gaps = 1/195 (0%)
Frame = +1
Query: 154 GNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRNL 333
GNSV+LVTNLN + P LF LFGVYGDV RVK+MFNKK ALVQ A+ QA A+ +L
Sbjct: 325 GNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHL 384
Query: 334 DACFLWGKQMHLHVSKTNVIQLPME-DANHGLTKDYSNSTLHRFKKPNSKNYQNIFPPSA 510
L+GK + +SK +QLP E + GLTKD+SNS LHRFKKP SKN+QNIFPPSA
Sbjct: 385 SGQRLYGKVLRATLSKHQAVQLpreGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSA 444
Query: 511 VLHLSNIPPTTGEGDLSEMIRSSGFEIKKFKFLPNDKKMALLELNSVEDAIHVLIDFHNH 690
LHLSNIPP+ DL + +G +K FKF D+KMAL++L SVE+AI LI+ HNH
Sbjct: 445 TLHLSNIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNH 504
Query: 691 KLSEKNHLRISFSKA 735
L E +HLR+SFSK+
Sbjct: 505 DLGENHHLRVSFSKS 519
>sp|Q29099|PTBP1_PIG Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I)
Length = 557
Score = 223 bits (569), Expect = 4e-58
Identities = 113/196 (57%), Positives = 142/196 (72%), Gaps = 1/196 (0%)
Frame = +1
Query: 151 SGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRN 330
+GNSV+LV+NLN E+ P +LF LFGVY DV RVK++FNKK ALVQ A+ QA A+ +
Sbjct: 360 AGNSVLLVSNLNPERVTPQSLFILFGVYCDVQRVKILFNKKENALVQMADGSQAQLAMSH 419
Query: 331 LDACFLWGKQMHLHVSKTNVIQLPME-DANHGLTKDYSNSTLHRFKKPNSKNYQNIFPPS 507
L+ L GK + + +SK +QLP E + GLTKDY NS LHRFKKP SKN+QNIFPPS
Sbjct: 420 LNGHKLHGKPVRITLSKHQNVQLpreGQEDQGLTKDYGNSPLHRFKKPGSKNFQNIFPPS 479
Query: 508 AVLHLSNIPPTTGEGDLSEMIRSSGFEIKKFKFLPNDKKMALLELNSVEDAIHVLIDFHN 687
A LHLSNIPP+ E DL + S+G +K FKF D+KMAL+++ SVE+AI LID HN
Sbjct: 480 ATLHLSNIPPSISEEDLKILFSSNGGIVKGFKFFQKDRKMALIQMGSVEEAIQALIDLHN 539
Query: 688 HKLSEKNHLRISFSKA 735
H L E +HLR+SFSK+
Sbjct: 540 HDLGENHHLRVSFSKS 555
>sp|P17225|PTBP1_MOUSE Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear
ribonucleoprotein I) (hnRNP I)
Length = 527
Score = 196 bits (498), Expect = 6e-50
Identities = 102/195 (52%), Positives = 128/195 (65%)
Frame = +1
Query: 151 SGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRN 330
+GNSV+LV+NLN E+ P +LF LFGVYGDV RVK++FNKK ALVQ A+ QA
Sbjct: 332 AGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGSQAQLGEPP 391
Query: 331 LDACFLWGKQMHLHVSKTNVIQLPMEDANHGLTKDYSNSTLHRFKKPNSKNYQNIFPPSA 510
A H V + + GLTKDY +S L RFKKP SKN+QNIFPPSA
Sbjct: 392 ERAQAAREVSAHYTVQASECAAAREGQEDQGLTKDYGSSPL-RFKKPGSKNFQNIFPPSA 450
Query: 511 VLHLSNIPPTTGEGDLSEMIRSSGFEIKKFKFLPNDKKMALLELNSVEDAIHVLIDFHNH 690
LHLSNIPP+ E DL + S+G +K FKF D+KMAL+++ SVE+A+ LI+ HNH
Sbjct: 451 TLHLSNIPPSVSEDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHNH 510
Query: 691 KLSEKNHLRISFSKA 735
L E +HLR+SFSK+
Sbjct: 511 DLGENHHLRVSFSKS 525
>sp|Q8R081|HNRPL_MOUSE Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Length = 555
Score = 81.6 bits (200), Expect = 2e-15
Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 15/213 (7%)
Frame = +1
Query: 142 GIDSGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTA 321
G + + V++V L+ K N D +F +F +YG+V +VK M +K A+V+ A+ A
Sbjct: 342 GPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRA 401
Query: 322 IRNLDACFLWGKQMHLHVSKTNVIQLPMEDANHGLT------KDYSNSTLHRFKKPNSKN 483
I +L+ F++G++M++ VSK I M ++GL KD+S S +RF P
Sbjct: 402 ITHLNNNFMFGQKMNVCVSKQPAI---MPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAA 458
Query: 484 YQNIFPPSAVLHLSNIPPTTGEGDLSEMIRSSGFE----IKKFKFLPNDKKMALLELNSV 651
I PS VLH N P E + E+ G + +K F LLE +S
Sbjct: 459 KNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSK 518
Query: 652 EDAIHVLIDFHNHKLSEKN-----HLRISFSKA 735
DA+ L +++++ N L++ FS A
Sbjct: 519 SDALETLGFLNHYQMKNPNGPYPYTLKLCFSTA 551
Score = 35.4 bits (80), Expect = 0.18
Identities = 42/159 (26%), Positives = 66/159 (41%), Gaps = 8/159 (5%)
Frame = +1
Query: 52 CNQMNHRSTDQ----SNWGFGSNQTQSSMFSSNTGIDSG--NSVVLVTNLNAEKS-NPDA 210
CN +N+ + +Q + F + T + DS NSV+L T LN S D
Sbjct: 117 CNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDV 176
Query: 211 LFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRNLDACFLWGKQMHLHVSKTNV 390
L+T+ G V R+ + A+V+F + Q A A +L+ ++ L +
Sbjct: 177 LYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKP 236
Query: 391 IQLPMEDANHGLTKDYSNSTLHRFKKPNSK-NYQNIFPP 504
+L + N T DY+N L P S N + PP
Sbjct: 237 TRLNV-FKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPP 274
>sp|P14866|HNRPL_HUMAN Heterogeneous nuclear ribonucleoprotein L (hnRNP L)
Length = 558
Score = 80.5 bits (197), Expect = 5e-15
Identities = 63/213 (29%), Positives = 102/213 (47%), Gaps = 15/213 (7%)
Frame = +1
Query: 142 GIDSGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTA 321
G + + V++V L+ K N D +F +F +YG+V +VK M +K A+V+ A+ A
Sbjct: 345 GPHADSPVLMVYGLDQSKMNGDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRA 404
Query: 322 IRNLDACFLWGKQMHLHVSKTNVIQLPMEDANHGLT------KDYSNSTLHRFKKPNSKN 483
I +L+ F++G+++++ VSK I M ++GL KD+S S +RF P
Sbjct: 405 ITHLNNNFMFGQKLNVCVSKQPAI---MPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAA 461
Query: 484 YQNIFPPSAVLHLSNIPPTTGEGDLSEMIRSSGFE----IKKFKFLPNDKKMALLELNSV 651
I PS VLH N P E + E+ G + +K F LLE S
Sbjct: 462 KNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESK 521
Query: 652 EDAIHVLIDFHNHKLSEKN-----HLRISFSKA 735
DA+ L +++++ N L++ FS A
Sbjct: 522 SDALETLGFLNHYQMKNPNGPYPYTLKLCFSTA 554
Score = 35.4 bits (80), Expect = 0.18
Identities = 42/159 (26%), Positives = 66/159 (41%), Gaps = 8/159 (5%)
Frame = +1
Query: 52 CNQMNHRSTDQ----SNWGFGSNQTQSSMFSSNTGIDSG--NSVVLVTNLNAEKS-NPDA 210
CN +N+ + +Q + F + T + DS NSV+L T LN S D
Sbjct: 120 CNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDV 179
Query: 211 LFTLFGVYGDVMRVKVMFNKKNTALVQFANHQQAMTAIRNLDACFLWGKQMHLHVSKTNV 390
L+T+ G V R+ + A+V+F + Q A A +L+ ++ L +
Sbjct: 180 LYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKP 239
Query: 391 IQLPMEDANHGLTKDYSNSTLHRFKKPNSK-NYQNIFPP 504
+L + N T DY+N L P S N + PP
Sbjct: 240 TRLNV-FKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPP 277
>sp|Q8WVV9|HNRLL_HUMAN Heterogeneous nuclear ribonucleoprotein L-like (Stromal
RNA-regulating factor) (BLOCK24 protein)
Length = 542
Score = 75.5 bits (184), Expect = 2e-13
Identities = 60/207 (28%), Positives = 102/207 (49%), Gaps = 9/207 (4%)
Frame = +1
Query: 115 QSSMFSSNTGIDSGNSVVLVTNLNAEKSNPDALFTLFGVYGDVMRVKVMFNKKNTALVQF 294
Q+S + G SG SVV+V+ L+ K N +F LF +YG++ +VK M TALV+
Sbjct: 321 QASSSYMHGGNPSG-SVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEM 379
Query: 295 ANHQQAMTAIRNLDACFLWGKQMHLHVSKTNVIQ----LPMEDANHGLTKDYSNSTLHRF 462
+ A+ +L+ L+GK++++ VSK + + +ED KD++ S +RF
Sbjct: 380 GDEYAVERAVTHLNNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSY-KDFAMSKNNRF 438
Query: 463 KKPNSKNYQNIFPPSAVLHLSNIPPTTGEGDLSEMIRS----SGFEIKKFKFLPNDKKMA 630
+ I PPS VLH N+P E +++ + + K F P+ K ++
Sbjct: 439 TSAGQASKNIIQPPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLS 498
Query: 631 -LLELNSVEDAIHVLIDFHNHKLSEKN 708
LLE DA+ L +++++ N
Sbjct: 499 GLLEWECKTDAVEALTALNHYQIRVPN 525
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,022,148
Number of Sequences: 369166
Number of extensions: 1792959
Number of successful extensions: 4503
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4305
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4491
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)