Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_I23
(626 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEP... 97 3e-20
sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEP... 97 3e-20
sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin... 97 4e-20
sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proep... 96 1e-19
sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 ... 62 2e-09
sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1 54 4e-07
sp|P81014|GRN2_CYPCA Granulin-2 53 7e-07
sp|P81013|GRN1_CYPCA Granulin-1 49 1e-05
sp|P81015|GRN3_CYPCA Granulin-3 47 4e-05
sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (... 40 0.004
>sp|P28799|GRN_HUMAN Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Paragranulin; Granulin-1 (Granulin G); Granulin-2
(Granulin F); Granulin-3 (Granulin B); Granulin-4
(Granulin A); Granulin-5 (Granulin C); Granulin-6
(Granulin D); Granulin-7 (Granulin E)]
Length = 593
Score = 97.1 bits (240), Expect = 3e-20
Identities = 52/143 (36%), Positives = 69/143 (48%), Gaps = 1/143 (0%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C + + C TCC G + CC A CC D++HCCP G+ CDL + RC+ +
Sbjct: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCI---TPT 182
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYT 414
PL K LP Q +R V L+ ++ R CPDGS+ CC +G Y
Sbjct: 183 GTHPLAK--KLPAQRTNRAVA----LSSSVMCPDARSRCPDGST------CCELPSGKYG 230
Query: 415 CCAFPFGICCPDR-NCCPRGTHC 480
CC P CC D +CCP+ T C
Sbjct: 231 CCPMPNATCCSDHLHCCPQDTVC 253
Score = 94.0 bits (232), Expect = 3e-19
Identities = 48/143 (33%), Positives = 67/143 (46%), Gaps = 1/143 (0%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C + ++ C TCC +G Y CC NA CC D +HCCP+ + CDL +C LSKE+
Sbjct: 208 CPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKC--LSKEN 265
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYT 414
L+ LP + + M CPDG +C +Q +G++
Sbjct: 266 ATTDLL--TKLPAHTVGD------------VKCDMEVSCPDGYTCCRLQ------SGAWG 305
Query: 415 CCAFPFGICCPDR-NCCPRGTHC 480
CC F +CC D +CCP G C
Sbjct: 306 CCPFTQAVCCEDHIHCCPAGFTC 328
Score = 88.2 bits (217), Expect = 2e-17
Identities = 47/144 (32%), Positives = 69/144 (47%), Gaps = 9/144 (6%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLVK 255
C +TCC S G + CCQ +AVCC D+ HCCP G TC+++ + C E +V
Sbjct: 450 CPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC--------EKEVVS 501
Query: 256 TMNLPKQSKSRLVVQRNRLNEFLLNIGMRRV-CPDGSSCYNIQPCCLTLTGSYTCCAFPF 432
++S ++G++ V C +G C++ Q CC + CC +
Sbjct: 502 AQPATFLARSP-------------HVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
Query: 433 GICCPDR-NCCP-------RGTHC 480
G+CC DR +CCP RGT C
Sbjct: 549 GVCCADRRHCCPAGFRCAARGTKC 572
Score = 87.0 bits (214), Expect = 3e-17
Identities = 51/143 (35%), Positives = 65/143 (45%), Gaps = 1/143 (0%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C N + C S TCC +G + CC AVCC D HCCP+G TC + + C S+
Sbjct: 366 CDNVSS-CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQ-CQRGSEI- 422
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYT 414
L K R + R +IG C +SC Q CC +L GS+
Sbjct: 423 -------VAGLEKMPARRASLSHPR------DIG----CDQHTSCPVGQTCCPSLGGSWA 465
Query: 415 CCAFPFGICCPDR-NCCPRGTHC 480
CC P +CC DR +CCP G C
Sbjct: 466 CCQLPHAVCCEDRQHCCPAGYTC 488
Score = 86.7 bits (213), Expect = 5e-17
Identities = 44/138 (31%), Positives = 60/138 (43%), Gaps = 3/138 (2%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEW--PL 249
C TCC ++G + CC AVCC D +HCCP G TCD Q C + W
Sbjct: 290 CPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQ-GPHQVPWMEKA 348
Query: 250 VKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFP 429
++LP + V C + SSC + CC +G + CC P
Sbjct: 349 PAHLSLPDPQALKRDVP----------------CDNVSSCPSSDTCCQLTSGEWGCCPIP 392
Query: 430 FGICCPD-RNCCPRGTHC 480
+CC D ++CCP+G C
Sbjct: 393 EAVCCSDHQHCCPQGYTC 410
Score = 76.6 bits (187), Expect = 5e-14
Identities = 45/147 (30%), Positives = 59/147 (40%), Gaps = 4/147 (2%)
Frame = +1
Query: 70 ALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPL 249
A C + +C + +G CC AV CGD HCCP G C + C
Sbjct: 65 AHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSC------------ 112
Query: 250 VKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGS-SCYNIQPCCLTLTGSYTCCAF 426
QR+ N ++G + CPD C + CC+ + GS+ CC
Sbjct: 113 ---------------FQRSGNN----SVGAIQ-CPDSQFECPDFSTCCVMVDGSWGCCPM 152
Query: 427 PFGICCPDR-NCCPRGTHCG--HESCI 498
P CC DR +CCP G C H CI
Sbjct: 153 PQASCCEDRVHCCPHGAFCDLVHTRCI 179
Score = 59.3 bits (142), Expect = 8e-09
Identities = 21/56 (37%), Positives = 30/56 (53%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEW 243
C +TCC G+ CC ++ VCC D+ HCCP G C + +C L +E+ W
Sbjct: 527 CHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKC--LRREAPRW 580
Score = 46.2 bits (108), Expect = 7e-05
Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 1/45 (2%)
Frame = +1
Query: 349 CPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPD-RNCCPRGTHC 480
C + C C T++G+ +CC FP + C D +CCPRG HC
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHC 105
>sp|P28797|GRN_CAVPO Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin;
Granulin-1; Granulin-2; Granulin-3; Granulin-4;
Granulin-5; Granulin-6; Granulin-7]
Length = 591
Score = 97.1 bits (240), Expect = 3e-20
Identities = 50/147 (34%), Positives = 67/147 (45%), Gaps = 3/147 (2%)
Frame = +1
Query: 70 ALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPL 249
A C R+TCC GG+ CCQ +AVCC D HCCP G TC+++ + C K + L
Sbjct: 445 ASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTCNVKARSC---EKAADGAHL 501
Query: 250 VKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFP 429
+ + M C D C++ Q CC G + CC F
Sbjct: 502 AAPLAVGSTGGV-----------------MDVACGDRHFCHDEQTCCRDSRGGWACCPFH 544
Query: 430 FGICCPD-RNCCPRGTHCGHES--CIH 501
G+CC D R+CCP G HC + C+H
Sbjct: 545 QGVCCKDQRHCCPAGFHCESQGTRCVH 571
Score = 96.7 bits (239), Expect = 4e-20
Identities = 54/147 (36%), Positives = 71/147 (48%), Gaps = 5/147 (3%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C G+ C TCC G + CC A CC D++HCCP G++CDL + RCV
Sbjct: 112 CPGGEFECPDSSTCCHMLDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHIRCVTALGSH 171
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNR-LNEFLLNIGMRR--VCPDG-SSCYNIQPCCLTLT 402
PL T LP Q + + ++ LL + +CPD S C + CCL +
Sbjct: 172 ---PL--TTKLPAQRTNYTGAEGTPVVSPGLLPAALPTSVICPDSRSQCPDDTTCCLLAS 226
Query: 403 GSYTCCAFPFGICCPDR-NCCPRGTHC 480
G Y CC P ICC D +CCP+ T C
Sbjct: 227 GEYGCCPMPNAICCSDHLHCCPQDTVC 253
Score = 94.7 bits (234), Expect = 2e-19
Identities = 47/146 (32%), Positives = 65/146 (44%), Gaps = 1/146 (0%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C + ++ C TCC +G Y CC NA+CC D +HCCP+ + CDL+ RC+ +K
Sbjct: 208 CPDSRSQCPDDTTCCLLASGEYGCCPMPNAICCSDHLHCCPQDTVCDLRQSRCLSQNK-- 265
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYT 414
KT+ S + V+ C SC Q CC +G +
Sbjct: 266 -----AKTLLTKLPSWTVWDVE----------------CDQEVSCPEGQTCCRLQSGKWG 304
Query: 415 CCAFPFGICCPDR-NCCPRGTHCGHE 489
CC FP +CC D +CCP C E
Sbjct: 305 CCPFPKAVCCEDHVHCCPERFRCHTE 330
Score = 72.8 bits (177), Expect = 7e-13
Identities = 46/151 (30%), Positives = 59/151 (39%), Gaps = 3/151 (1%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
CQ+ A C +C + AG CC A+ CGD HCCP G C C+ +
Sbjct: 47 CQS-PANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCI----QR 101
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYT 414
+ L+ + P G CPD S+ CC L GS+
Sbjct: 102 PDIHLLGAVQCP---------------------GGEFECPDSST------CCHMLDGSWG 134
Query: 415 CCAFPFGICCPDR-NCCPRGTHCG--HESCI 498
CC P CC DR +CCP G C H C+
Sbjct: 135 CCPMPQASCCEDRVHCCPHGASCDLVHIRCV 165
Score = 65.5 bits (158), Expect = 1e-10
Identities = 25/56 (44%), Positives = 30/56 (53%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEW 243
C +TCC GG+ CC VCC DQ HCCP G C+ Q RCV+ K + W
Sbjct: 524 CHDEQTCCRDSRGGWACCPFHQGVCCKDQRHCCPAGFHCESQGTRCVH-KKSLLHW 578
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/139 (25%), Positives = 50/139 (35%), Gaps = 1/139 (0%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLV- 252
C +TCC ++G + CC AVCC D +HCCPE C + C + ++ P
Sbjct: 289 CPEGQTCCRLQSGKWGCCPFPKAVCCEDHVHCCPERFRCHTEKDTC---EQGLLQVPWAQ 345
Query: 253 KTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPF 432
KT P + + C + SC CC +G + CC
Sbjct: 346 KTPAQPSRPSQPSPPGPPGPPSPPGPLRSEISCDEVVSCRPGNICCRLASGEWGCCPSSE 405
Query: 433 GICCPDRNCCPRGTHCGHE 489
G C C G E
Sbjct: 406 GYLCMAGERCQVGDRLAPE 424
Score = 49.7 bits (117), Expect = 6e-06
Identities = 33/118 (27%), Positives = 49/118 (41%), Gaps = 6/118 (5%)
Frame = +1
Query: 145 VCC---GDQMHCCP--EGSTCDLQNKRCVYLSKESMEWPLVKTMNLPKQSKSRLVVQRNR 309
+CC + CCP EG C + +RC + + E M+L + +
Sbjct: 389 ICCRLASGEWGCCPSSEGYLC-MAGERCQVGDRLAPEKMAAHLMSLSQTT---------- 437
Query: 310 LNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPD-RNCCPRGTHC 480
++G C +SC Q CC L G + CC P +CC D ++CCP G C
Sbjct: 438 ------DVG----CDQHASCPVRQTCCPKLGGGWACCQLPHAVCCEDGQHCCPAGYTC 485
Score = 42.0 bits (97), Expect = 0.001
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 3/55 (5%)
Frame = +1
Query: 343 RVCPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPD-RNCCPRGTHCGHE--SCI 498
R C ++C C LT G+ CC F + C D +CCP G HC + +CI
Sbjct: 45 RPCQSPANCPIGHSCVLTAAGTAACCPFSQAMACGDGHHCCPYGFHCSTDGGTCI 99
>sp|P23785|GRN_RAT Granulins precursor [Contains: Acrogranin; Granulin-1 (Granulin G);
Granulin-2 (Granulin F); Granulin-3 (Granulin B)
(Epithelin-2); Granulin-4 (Granulin A) (Epithelin-1);
Granulin-5 (Granulin C); Granulin-6 (Granulin D);
Granulin-7 (Granulin E)]
Length = 588
Score = 96.7 bits (239), Expect = 4e-20
Identities = 51/144 (35%), Positives = 66/144 (45%), Gaps = 2/144 (1%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C + C TCC G + CC A CC D++HCCP G++CDL + RC+ +
Sbjct: 125 CPGSQFECPDSATCCIMIDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCI---SPT 181
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDG-SSCYNIQPCCLTLTGSY 411
PL+K P Q +R V VCPD + C + CC TG Y
Sbjct: 182 GTHPLLK--KFPAQRTNRAVA------------SFSVVCPDAKTQCPDDSTCCELPTGKY 227
Query: 412 TCCAFPFGICCPDR-NCCPRGTHC 480
CC P ICC D +CCP+ T C
Sbjct: 228 GCCPMPNAICCSDHLHCCPQDTVC 251
Score = 96.7 bits (239), Expect = 4e-20
Identities = 49/147 (33%), Positives = 68/147 (46%), Gaps = 1/147 (0%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C + K C TCC G Y CC NA+CC D +HCCP+ + CDL +C+ SK+
Sbjct: 206 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCI--SKDY 263
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYT 414
+ K P +NE ++ + CPDG + CC TG++
Sbjct: 264 TTDLMTKLPGYP-------------VNEVKCDLEVS--CPDGYT------CCRLNTGAWG 302
Query: 415 CCAFPFGICCPDR-NCCPRGTHCGHES 492
CC F +CC D +CCP G C E+
Sbjct: 303 CCPFTKAVCCEDHIHCCPAGFQCHTET 329
Score = 93.6 bits (231), Expect = 4e-19
Identities = 48/136 (35%), Positives = 65/136 (47%), Gaps = 1/136 (0%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLVK 255
C +TCC S G + CCQ +AVCC D+ HCCP G TC+++ + C E +
Sbjct: 447 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-----EKDAGSVQP 501
Query: 256 TMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPFG 435
+M+L SK V C G C++ Q CC G + CC + G
Sbjct: 502 SMDLTFGSKVGNV-----------------ECGAGHFCHDNQSCCKDSQGGWACCPYVKG 544
Query: 436 ICCPD-RNCCPRGTHC 480
+CC D R+CCP G HC
Sbjct: 545 VCCRDGRHCCPIGFHC 560
Score = 83.2 bits (204), Expect = 5e-16
Identities = 44/141 (31%), Positives = 62/141 (43%), Gaps = 3/141 (2%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEW--PL 249
C TCC G + CC AVCC D +HCCP G C + C L + W +
Sbjct: 287 CPDGYTCCRLNTGAWGCCPFTKAVCCEDHIHCCPAGFQCHTETGTC-ELGVLQVPWMKKV 345
Query: 250 VKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFP 429
+++LP + +N + C D SSC + CC +G + CC P
Sbjct: 346 TASLSLPDPQ-----ILKNDV-----------PCDDFSSCPSNNTCCRLSSGDWGCCPMP 389
Query: 430 FGICCPD-RNCCPRGTHCGHE 489
+CC D ++CCP+G C E
Sbjct: 390 EAVCCLDHQHCCPQGFKCMDE 410
Score = 82.4 bits (202), Expect = 9e-16
Identities = 44/136 (32%), Positives = 60/136 (44%), Gaps = 1/136 (0%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLVK 255
C S TCC +G + CC AVCC D HCCP+G C + Y K ++
Sbjct: 369 CPSNNTCCRLSSGDWGCCPMPEAVCCLDHQHCCPQGFKCMDEG----YCQKGDRMVAGLE 424
Query: 256 TMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPFG 435
M + + ++Q + C +SC Q CC +L GS+ CC P
Sbjct: 425 KMPV----RQTTLLQHGDIG-----------CDQHTSCPVGQTCCPSLKGSWACCQLPHA 469
Query: 436 ICCPDR-NCCPRGTHC 480
+CC DR +CCP G C
Sbjct: 470 VCCEDRQHCCPAGYTC 485
Score = 74.7 bits (182), Expect = 2e-13
Identities = 42/144 (29%), Positives = 55/144 (38%), Gaps = 3/144 (2%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLVK 255
C +C + +G CC V C D HCCP G C K C +S L+
Sbjct: 67 CPDGYSCLLTVSGTSSCCPFSEGVSCDDGQHCCPRGFHCSADGKSCSQISDS-----LLG 121
Query: 256 TMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPFG 435
+ P G + CPD ++ CC+ + GS+ CC P
Sbjct: 122 AVQCP---------------------GSQFECPDSAT------CCIMIDGSWGCCPMPQA 154
Query: 436 ICCPDR-NCCPRGTHCG--HESCI 498
CC DR +CCP G C H CI
Sbjct: 155 SCCEDRVHCCPHGASCDLVHTRCI 178
Score = 57.4 bits (137), Expect = 3e-08
Identities = 21/59 (35%), Positives = 31/59 (52%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLV 252
C ++CC GG+ CC + VCC D HCCP G C + +C L K++ W ++
Sbjct: 522 CHDNQSCCKDSQGGWACCPYVKGVCCRDGRHCCPIGFHCSAKGTKC--LRKKTPRWDIL 578
Score = 51.2 bits (121), Expect = 2e-06
Identities = 23/49 (46%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Frame = +1
Query: 337 MRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPD-RNCCPRGTHC 480
+R CPDG SC LT++G+ +CC F G+ C D ++CCPRG HC
Sbjct: 63 IRDHCPDGYSCL------LTVSGTSSCCPFSEGVSCDDGQHCCPRGFHC 105
>sp|P28798|GRN_MOUSE Granulins precursor (Acrogranin) (Proepithelin) (PEPI) (PC
cell-derived growth factor) (PCDGF) [Contains: Granulin
1; Granulin 2; Granulin 3; Granulin 4; Granulin 5;
Granulin 6; Granulin 7]
Length = 589
Score = 95.5 bits (236), Expect = 1e-19
Identities = 51/144 (35%), Positives = 67/144 (46%), Gaps = 2/144 (1%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C + C TCC G + CC A CC D++HCCP G++CDL + RCV +
Sbjct: 125 CPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCV---SPT 181
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDG-SSCYNIQPCCLTLTGSY 411
L+K P Q +R V ++ VCPD + C + CC TG Y
Sbjct: 182 GTHTLLK--KFPAQKTNRAV-----------SLPFSVVCPDAKTQCPDDSTCCELPTGKY 228
Query: 412 TCCAFPFGICCPDR-NCCPRGTHC 480
CC P ICC D +CCP+ T C
Sbjct: 229 GCCPMPNAICCSDHLHCCPQDTVC 252
Score = 95.1 bits (235), Expect = 1e-19
Identities = 49/146 (33%), Positives = 63/146 (43%), Gaps = 1/146 (0%)
Frame = +1
Query: 55 CQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKES 234
C + K C TCC G Y CC NA+CC D +HCCP+ + CDL +C LSK
Sbjct: 207 CPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKC--LSKNY 264
Query: 235 MEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYT 414
L K P + + M CP+G + CC TG++
Sbjct: 265 TTDLLTKLPGYPVKE---------------VKCDMEVSCPEGYT------CCRLNTGAWG 303
Query: 415 CCAFPFGICCPDR-NCCPRGTHCGHE 489
CC F +CC D +CCP G C E
Sbjct: 304 CCPFAKAVCCEDHIHCCPAGFQCHTE 329
Score = 94.4 bits (233), Expect = 2e-19
Identities = 46/136 (33%), Positives = 67/136 (49%), Gaps = 1/136 (0%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLVK 255
C +TCC S G + CCQ +AVCC D+ HCCP G TC+++ + C + ++ P++
Sbjct: 448 CPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTC-EKDVDFIQPPVLL 506
Query: 256 TMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPFG 435
T+ PK C +G C++ Q CC G + CC + G
Sbjct: 507 TLG-PKVGNVE--------------------CGEGHFCHDNQTCCKDSAGVWACCPYLKG 545
Query: 436 ICCPD-RNCCPRGTHC 480
+CC D R+CCP G HC
Sbjct: 546 VCCRDGRHCCPGGFHC 561
Score = 89.0 bits (219), Expect = 9e-18
Identities = 50/137 (36%), Positives = 66/137 (48%), Gaps = 2/137 (1%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSK-ESMEWPLV 252
C + TCC +G + CC AVCC D HCCP+G TC Q Y K ++M L
Sbjct: 370 CPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQG----YCQKGDTMVAGLE 425
Query: 253 KTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPF 432
K +P + + L + +IG C +SC Q CC +L GS+ CC P
Sbjct: 426 K---IPARQTTPLQIG---------DIG----CDQHTSCPVGQTCCPSLKGSWACCQLPH 469
Query: 433 GICCPDR-NCCPRGTHC 480
+CC DR +CCP G C
Sbjct: 470 AVCCEDRQHCCPAGYTC 486
Score = 80.9 bits (198), Expect = 2e-15
Identities = 39/136 (28%), Positives = 58/136 (42%), Gaps = 1/136 (0%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLVK 255
C TCC G + CC AVCC D +HCCP G C + C ++ P +K
Sbjct: 288 CPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTC---EMGILQVPWMK 344
Query: 256 TMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTGSYTCCAFPFG 435
+ P + +++ + C D + C CC +G + CC P
Sbjct: 345 KVIAPLRLPDPQILKSD------------TPCDDFTRCPTNNTCCKLNSGDWGCCPIPEA 392
Query: 436 ICCPD-RNCCPRGTHC 480
+CC D ++CCP+G C
Sbjct: 393 VCCSDNQHCCPQGFTC 408
Score = 76.6 bits (187), Expect = 5e-14
Identities = 43/154 (27%), Positives = 61/154 (39%), Gaps = 3/154 (1%)
Frame = +1
Query: 46 ENACQNGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLS 225
+ +CQ C + +C + +G CC V CGD HCCP+G C K C +S
Sbjct: 58 DGSCQT-HGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMS 116
Query: 226 KESMEWPLVKTMNLPKQSKSRLVVQRNRLNEFLLNIGMRRVCPDGSSCYNIQPCCLTLTG 405
+ + P G + CPD ++ CC+ + G
Sbjct: 117 DNPL-----GAVQCP---------------------GSQFECPDSAT------CCIMVDG 144
Query: 406 SYTCCAFPFGICCPDR-NCCPRGTHCG--HESCI 498
S+ CC P CC DR +CCP G C H C+
Sbjct: 145 SWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCV 178
Score = 56.6 bits (135), Expect = 5e-08
Identities = 23/66 (34%), Positives = 32/66 (48%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCVYLSKESMEWPLVK 255
C +TCC AG + CC + VCC D HCCP G C + +C L K+ W +
Sbjct: 523 CHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKC--LRKKIPRWDMFL 580
Query: 256 TMNLPK 273
+P+
Sbjct: 581 RDPVPR 586
>sp|P80059|PMD1_LOCMI Pars intercerebralis major peptide D1 (PMP-D1)
Length = 54
Score = 61.6 bits (148), Expect = 2e-09
Identities = 21/47 (44%), Positives = 29/47 (61%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCV 216
C +TCC + G CC +K VCC D +HCCP G+ CD ++RC+
Sbjct: 7 CPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
Score = 45.8 bits (107), Expect = 9e-05
Identities = 20/48 (41%), Positives = 25/48 (52%), Gaps = 3/48 (6%)
Frame = +1
Query: 364 SCYNIQPCCLTLTGSYTCCAFPFGICCPDR-NCCPRGTHC--GHESCI 498
+C + CC T G CC + G+CC D +CCP GT C H CI
Sbjct: 6 TCPGTETCCTTPQGEEGCCPYKEGVCCLDGIHCCPSGTVCDEDHRRCI 53
>sp|P80930|ENA1_HORSE Antimicrobial peptide eNAP-1
Length = 46
Score = 53.5 bits (127), Expect = 4e-07
Identities = 18/36 (50%), Positives = 21/36 (58%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEG 183
C +TCC + GG CC + VCC DQ HCCP G
Sbjct: 10 CHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
Score = 48.9 bits (115), Expect = 1e-05
Identities = 18/42 (42%), Positives = 24/42 (57%), Gaps = 1/42 (2%)
Frame = +1
Query: 349 CPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPD-RNCCPRG 471
C +G C++ Q CC G CC + G+CC D R+CCP G
Sbjct: 4 CGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVG 45
>sp|P81014|GRN2_CYPCA Granulin-2
Length = 57
Score = 52.8 bits (125), Expect = 7e-07
Identities = 21/52 (40%), Positives = 25/52 (48%)
Frame = +1
Query: 61 NGKALCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCV 216
N + C SR TCC S G + CC CC D HCC G CD + C+
Sbjct: 5 NARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTLCL 56
Score = 40.4 bits (93), Expect = 0.004
Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 1/51 (1%)
Frame = +1
Query: 349 CPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPD-RNCCPRGTHCGHESCI 498
C ++C + CC + G + CC F G CC D R+CC G C S +
Sbjct: 4 CNARTTCPSRTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYRCDSTSTL 54
>sp|P81013|GRN1_CYPCA Granulin-1
Length = 57
Score = 48.5 bits (114), Expect = 1e-05
Identities = 18/48 (37%), Positives = 23/48 (47%)
Frame = +1
Query: 73 LCGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCV 216
+C TCC S G + CC CC D +HCC G CD + C+
Sbjct: 9 ICPDGTTCCLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTSTHCL 56
Score = 47.0 bits (110), Expect = 4e-05
Identities = 21/50 (42%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Frame = +1
Query: 346 VCPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPDR-NCCPRGTHCGHES 492
+CPDG++C CL+ G + CC F G CC D +CC G HC S
Sbjct: 9 ICPDGTTC------CLSPYGVWYCCPFSMGQCCRDGIHCCRHGYHCDSTS 52
>sp|P81015|GRN3_CYPCA Granulin-3
Length = 57
Score = 47.0 bits (110), Expect = 4e-05
Identities = 19/47 (40%), Positives = 22/47 (46%)
Frame = +1
Query: 76 CGSRKTCCASKAGGYQCCQHKNAVCCGDQMHCCPEGSTCDLQNKRCV 216
C S TCC S G + CC CC D HCC G CD + C+
Sbjct: 10 CPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTLCL 56
Score = 45.4 bits (106), Expect = 1e-04
Identities = 20/51 (39%), Positives = 26/51 (50%), Gaps = 1/51 (1%)
Frame = +1
Query: 349 CPDGSSCYNIQPCCLTLTGSYTCCAFPFGICCPD-RNCCPRGTHCGHESCI 498
C G +C + CC + G + CC F G CC D R+CC G HC S +
Sbjct: 4 CDAGITCPSGTTCCRSPFGVWYCCPFLMGQCCRDGRHCCRHGYHCDSTSTL 54
>sp|P43297|RD21A_ARATH Cysteine proteinase RD21a precursor (RD21)
Length = 462
Score = 40.4 bits (93), Expect = 0.004
Identities = 23/56 (41%), Positives = 26/56 (46%), Gaps = 5/56 (8%)
Frame = +1
Query: 82 SRKTCCASKAGGY----QCCQHKNAVCCGDQMHCCP-EGSTCDLQNKRCVYLSKES 234
S CC + G Y CC + A CC D CCP E CDL C+ LSK S
Sbjct: 384 SNTCCCLFEYGKYCFAWGCCPLEAATCCDDNYSCCPHEYPVCDLDQGTCL-LSKNS 438
Score = 33.5 bits (75), Expect = 0.46
Identities = 16/44 (36%), Positives = 20/44 (45%), Gaps = 5/44 (11%)
Frame = +1
Query: 349 CPDGSSCYNIQPCCLTLTGSYT----CCAFPFGICCPDR-NCCP 465
CP+ ++C CCL G Y CC CC D +CCP
Sbjct: 381 CPESNTC-----CCLFEYGKYCFAWGCCPLEAATCCDDNYSCCP 419
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,834,222
Number of Sequences: 369166
Number of extensions: 1545123
Number of successful extensions: 5138
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4254
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4977
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 4974853140
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)