Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_I14
(805 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P11833|TBB_PARLI Tubulin beta chain (Beta tubulin) 500 e-141
sp|P30883|TBB4_XENLA Tubulin beta-4 chain 500 e-141
sp|P41386|TBB_HALDI Tubulin beta chain (Beta tubulin) 500 e-141
sp|P02554|TBB_PIG Tubulin beta chain 500 e-141
sp|P68372|TBBX_MOUSE Tubulin beta-? chain >gi|55977480|sp|P... 500 e-141
sp|Q91240|TBB_PSEAM Tubulin beta chain (Beta tubulin) 498 e-141
sp|P04691|TBB1_RAT Tubulin beta chain (T beta-15) 498 e-141
sp|P32882|TBB2_CHICK Tubulin beta-2 chain (Beta-tubulin cla... 498 e-141
sp|Q24560|TBB1_DROME Tubulin beta-1 chain (Beta-1 tubulin) 497 e-140
sp|P61858|TBB2_DROHY Tubulin beta-2 chain (Beta-2 tubulin) ... 497 e-140
>sp|P11833|TBB_PARLI Tubulin beta chain (Beta tubulin)
Length = 447
Score = 500 bits (1288), Expect = e-141
Identities = 243/246 (98%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNV 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|P30883|TBB4_XENLA Tubulin beta-4 chain
Length = 445
Score = 500 bits (1288), Expect = e-141
Identities = 243/246 (98%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNV 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|P41386|TBB_HALDI Tubulin beta chain (Beta tubulin)
Length = 341
Score = 500 bits (1288), Expect = e-141
Identities = 243/246 (98%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 80 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 139
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 140 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 199
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 200 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNV 259
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 260 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 319
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 320 FLHWYT 325
>sp|P02554|TBB_PIG Tubulin beta chain
Length = 445
Score = 500 bits (1287), Expect = e-141
Identities = 243/246 (98%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNV 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|P68372|TBBX_MOUSE Tubulin beta-? chain
sp|P68371|TBBX_HUMAN Tubulin beta-? chain (Tubulin beta-2 chain)
Length = 445
Score = 500 bits (1287), Expect = e-141
Identities = 243/246 (98%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNV 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|Q91240|TBB_PSEAM Tubulin beta chain (Beta tubulin)
Length = 445
Score = 498 bits (1283), Expect = e-141
Identities = 242/246 (98%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNV 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMS+TFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSSTFIGNSTAIQELFKRMSEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|P04691|TBB1_RAT Tubulin beta chain (T beta-15)
Length = 445
Score = 498 bits (1282), Expect = e-141
Identities = 241/246 (97%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSV+PSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFD+KNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNV 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|P32882|TBB2_CHICK Tubulin beta-2 chain (Beta-tubulin class-II)
Length = 445
Score = 498 bits (1282), Expect = e-141
Identities = 241/246 (97%), Positives = 246/246 (100%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSV+PSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFD+KNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLNV
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNV 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|Q24560|TBB1_DROME Tubulin beta-1 chain (Beta-1 tubulin)
Length = 447
Score = 497 bits (1279), Expect = e-140
Identities = 240/246 (97%), Positives = 245/246 (99%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNT+SVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVS TMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLN+
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNI 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKR+SEQFTAMFRRKA
Sbjct: 334 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
>sp|P61858|TBB2_DROHY Tubulin beta-2 chain (Beta-2 tubulin)
sp|P61857|TBB2_DROME Tubulin beta-2 chain (Beta-2 tubulin)
Length = 446
Score = 497 bits (1279), Expect = e-140
Identities = 241/246 (97%), Positives = 245/246 (99%)
Frame = +2
Query: 68 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFR 247
KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDET+CIDNEALYDICFR
Sbjct: 154 KIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFR 213
Query: 248 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 427
TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL
Sbjct: 214 TLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPL 273
Query: 428 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAALFRGRMSMKEVDEQMLNV 607
TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAA+FRGRMSMKEVDEQMLN+
Sbjct: 274 TSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNI 333
Query: 608 QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 787
QNKNSS+FVEWIPNN KTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA
Sbjct: 334 QNKNSSFFVEWIPNNCKTAVCDIPPRGLKMSATFIGNSTAIQELFKRVSEQFTAMFRRKA 393
Query: 788 FLHWYT 805
FLHWYT
Sbjct: 394 FLHWYT 399
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,101,039
Number of Sequences: 369166
Number of extensions: 1968337
Number of successful extensions: 5447
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5060
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5254
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7618580670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)