Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_I06
(846 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase 290 3e-78
sp|Q9Z2W0|DNPEP_MOUSE Aspartyl aminopeptidase 281 2e-75
sp|O36014|DNPEP_SCHPO Putative aspartyl aminopeptidase 239 9e-63
sp|Q19087|DNPEP_CAEEL Putative aspartyl aminopeptidase 238 1e-62
sp|P38821|DNPEP_YEAST Putative aspartyl aminopeptidase 232 9e-61
sp|Q88M44|APEB_PSEPK Probable M18-family aminopeptidase 2 190 4e-48
sp|Q9HYZ3|APEB_PSEAE Probable M18-family aminopeptidase 2 186 5e-47
sp|Q97LF4|APEB_CLOAB Probable M18-family aminopeptidase 2 184 3e-46
sp|Q87YC5|APEB_PSESM Probable M18-family aminopeptidase 2 180 5e-45
sp|Q82F74|APEB_STRAW Probable M18-family aminopeptidase 2 128 2e-29
>sp|Q9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase
Length = 475
Score = 290 bits (743), Expect = 3e-78
Identities = 137/280 (48%), Positives = 198/280 (70%), Gaps = 5/280 (1%)
Frame = +2
Query: 20 AKNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTIIALA 199
AK L+KF+++SP+P+HAVA ++ L+ GF E+ E ++WN+KP F+T+N STIIA A
Sbjct: 18 AKELLKFVNRSPSPFHAVAECRNRLLQAGFSELKETEKWNIKPESKYFMTRNSSTIIAFA 77
Query: 200 IGGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRDLTVA 379
+GG+Y PGNGFS+IGAHTDSPCLR+K S + + ++GVETYGGG+W TWFDRDLT+A
Sbjct: 78 VGGQYVPGNGFSLIGAHTDSPCLRVKRRSRRSQVGFQQVGVETYGGGIWSTWFDRDLTLA 137
Query: 380 GRCVVR--ESDKYRHLLVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPVLCTTIYE 553
GR +V+ S + LV++ RPI RIP LA+HL R++N++F PN E+HL P+L T I E
Sbjct: 138 GRVIVKCPTSGRLEQQLVHVERPILRIPHLAIHLQRNINENFGPNTEMHLVPILATAIQE 197
Query: 554 QINKINSEQKDSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGIHQEF 733
++ K E H +VL+ + L + +DIV++ELCLAD QP+ +GG + EF
Sbjct: 198 ELEKGTPEPGPLNAVDERHHSVLMSLLCAHLGLSPKDIVEMELCLADTQPAVLGGAYDEF 257
Query: 734 VFAPRLDNLFNCYTSVQALVESLE---SVSDDTNIRAVCL 844
+FAPRLDNL +C+ ++QAL++S S++ + ++R V L
Sbjct: 258 IFAPRLDNLHSCFCALQALIDSCAGPGSLATEPHVRMVTL 297
>sp|Q9Z2W0|DNPEP_MOUSE Aspartyl aminopeptidase
Length = 473
Score = 281 bits (719), Expect = 2e-75
Identities = 130/280 (46%), Positives = 197/280 (70%), Gaps = 5/280 (1%)
Frame = +2
Query: 20 AKNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTIIALA 199
A+ L+KF+++SP+P+H VA + L+ GF+E+ E + W++ P + F+T+N S+IIA A
Sbjct: 16 ARELLKFVNRSPSPFHVVAECRSRLLQAGFRELKETEGWDIVPENNYFLTRNSSSIIAFA 75
Query: 200 IGGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRDLTVA 379
+GG+Y PGNGFS+IGAHTDSPCLR+K S + Y ++GVETYGGG+W TWFDRDLT+A
Sbjct: 76 VGGQYVPGNGFSLIGAHTDSPCLRVKRKSRRSQVGYHQVGVETYGGGIWSTWFDRDLTLA 135
Query: 380 GRCVVR--ESDKYRHLLVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPVLCTTIYE 553
GR +++ S + LV++ RPI RIP LA+HL R++N++F PN E+HL P+L T + E
Sbjct: 136 GRVIIKCPTSGRLEQRLVHIERPILRIPHLAIHLQRNINENFGPNTEIHLVPILATAVQE 195
Query: 554 QINKINSEQKDSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGIHQEF 733
++ K E + H +VL+ + L + + I+++ELCLAD QP+ +GG ++EF
Sbjct: 196 ELEKGTPEPGPLGATDERHHSVLMSLLCTHLGLSPDSIMEMELCLADTQPAVLGGAYEEF 255
Query: 734 VFAPRLDNLFNCYTSVQALVESL---ESVSDDTNIRAVCL 844
+FAPRLDNL +C+ ++QAL++S S++ D ++R V L
Sbjct: 256 IFAPRLDNLHSCFCALQALIDSCASPASLARDPHVRMVTL 295
>sp|O36014|DNPEP_SCHPO Putative aspartyl aminopeptidase
Length = 467
Score = 239 bits (609), Expect = 9e-63
Identities = 130/290 (44%), Positives = 190/290 (65%), Gaps = 12/290 (4%)
Frame = +2
Query: 5 TSLNYAKNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLK--PNDLVFVTKNH 178
T+ + A + + F++ SPTPYHAV ++ + +++GF+ + E+ +W K P + FVT+N
Sbjct: 4 TAKSCALDFLDFVNASPTPYHAVQNLAEHYMSHGFQYLSEKSDWQSKIEPGNSYFVTRNK 63
Query: 179 STIIALAIGGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWF 358
S+IIA +IG K+KPGNGFS+I HTDSP LRLKP S++ + Y+++GVE YGGG+W+TWF
Sbjct: 64 SSIIAFSIGKKWKPGNGFSIIATHTDSPTLRLKPKSQKSAYGYLQVGVEKYGGGIWHTWF 123
Query: 359 DRDLTVAGRCVVRESDKYRHLLVNLH--RPIARIPTLAVHLDRSVNDSFAPNKELHLNPV 532
DRDL++AGR +V E D R + N+H RP+ RIPTLA+HLD S N SF+ N E P+
Sbjct: 124 DRDLSLAGRVMVEEEDG-RVIQYNVHIDRPLLRIPTLAIHLDPSANSSFSFNMETEFVPL 182
Query: 533 LCTTIYEQINKINSEQKDSPTSSLNHPTVLLEAIAQELKVKVE------DIVDVELCLAD 694
+ N++ E+ +HP VLL +A E+ +E IVD EL L D
Sbjct: 183 IGLE-----NELAKEETSDNGDKYHHP-VLLSLLANEISKSLETTIDPSKIVDFELILGD 236
Query: 695 CQPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLE--SVSDDTNIRAV 838
+ + +GGIH+EFVF+PRLDNL + + QAL +SLE S+ +++ +R V
Sbjct: 237 AEKARLGGIHEEFVFSPRLDNLGMTFCASQALTKSLENNSLDNESCVRVV 286
>sp|Q19087|DNPEP_CAEEL Putative aspartyl aminopeptidase
Length = 470
Score = 238 bits (608), Expect = 1e-62
Identities = 123/281 (43%), Positives = 173/281 (61%), Gaps = 7/281 (2%)
Frame = +2
Query: 20 AKNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTIIALA 199
A+ I +++K+ TP+HA VKD L+ GF E+ E W+++P FVTKN S I+A A
Sbjct: 16 AQEFINYLNKAVTPFHATQEVKDRLLQAGFTELPESGHWDIQPTSKYFVTKNRSAILAFA 75
Query: 200 IGGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRDLTVA 379
+GG YKPG+GFS++ HTDSPCLR+KP S Q S+ ++++GV TYGGG+W TWFDRDL+VA
Sbjct: 76 VGGSYKPGSGFSIVVGHTDSPCLRVKPISHQKSDKFLQVGVSTYGGGIWRTWFDRDLSVA 135
Query: 380 GRCVVRESDKYRHLLVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPVLCTTIYEQI 559
G +V+ +K +H L+++ +P+ IP LA+HL+ +F PN E L P+L T I
Sbjct: 136 GLVIVKNGEKLQHKLIDVKKPVLFIPNLAIHLETD-RTTFKPNTETELRPILETFAAAGI 194
Query: 560 NKINSEQK----DSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGIHQ 727
N + D + NH L IA+E + EDIVD++L L D + I G+
Sbjct: 195 NAPQKPESTGFADPRNITNNHHPQFLGLIAKEAGCQPEDIVDLDLYLYDTNKAAIVGMED 254
Query: 728 EFVFAPRLDNLFNCYTSVQALVESL--ESVSDDTNIR-AVC 841
EF+ RLDN YT++ L+ESL ES +D IR A C
Sbjct: 255 EFISGARLDNQVGTYTAISGLLESLTGESFKNDPQIRIAAC 295
>sp|P38821|DNPEP_YEAST Putative aspartyl aminopeptidase
Length = 490
Score = 232 bits (592), Expect = 9e-61
Identities = 124/280 (44%), Positives = 180/280 (64%), Gaps = 12/280 (4%)
Frame = +2
Query: 14 NYAKNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEW--NLKPNDLVFVTKNHSTI 187
+Y K + F++ S +PYH V ++K LV+ GFKE+ E+D W ++ FVT+N S+I
Sbjct: 17 DYPKEFVSFLNSSHSPYHTVHNIKKHLVSNGFKELSERDSWAGHVAQKGKYFVTRNGSSI 76
Query: 188 IALAIGGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRD 367
IA A+GGK++PGN ++ GAHTDSP LR+KP S+++S Y+++GVETYGG +W++WFD+D
Sbjct: 77 IAFAVGGKWEPGNPIAITGAHTDSPALRIKPISKRVSEKYLQVGVETYGGAIWHSWFDKD 136
Query: 368 LTVAGRCVVRESDKYRHL--LVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPV--- 532
L VAGR V+++ + + LV+L+RP+ +IPTLA+HLDR VN F N+E L P+
Sbjct: 137 LGVAGRVFVKDAKTGKSIARLVDLNRPLLKIPTLAIHLDRDVNQKFEFNRETQLLPIGGL 196
Query: 533 ----LCTTIYEQINKINSEQKDSPTSSLNHPTVLLEAIAQELKV-KVEDIVDVELCLADC 697
++IN N E T H LL IA+EL + +EDI D EL L D
Sbjct: 197 QEDKTEAKTEKEIN--NGEFTSIKTIVQRHHAELLGLIAKELAIDTIEDIEDFELILYDH 254
Query: 698 QPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSD 817
ST+GG + EFVF+ RLDNL +C+TS+ L + ++ D
Sbjct: 255 NASTLGGFNDEFVFSGRLDNLTSCFTSMHGLTLAADTEID 294
>sp|Q88M44|APEB_PSEPK Probable M18-family aminopeptidase 2
Length = 429
Score = 190 bits (483), Expect = 4e-48
Identities = 101/265 (38%), Positives = 155/265 (58%)
Frame = +2
Query: 29 LIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTIIALAIGG 208
LI+F+ SPTP+HA AS+ L G+K + E+D W+ + +VT+N S+IIA+ +G
Sbjct: 9 LIEFLKASPTPFHATASLVQRLEAAGYKRLDERDSWDTETGGRYYVTRNDSSIIAIKLGK 68
Query: 209 KYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRDLTVAGRC 388
+ NG M+GAHTDSPCLR+KP E +++LGVE YGG L WFDRDL++AGR
Sbjct: 69 QSPLLNGIRMVGAHTDSPCLRVKPQPELQRQGFLQLGVEVYGGALLAPWFDRDLSLAGRV 128
Query: 389 VVRESDKYRHLLVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPVLCTTIYEQINKI 568
R K L++ P+A IP LA+HL+R+ N+ +A N + L P+L ++
Sbjct: 129 TYRRDGKVESQLIDFKLPVAIIPNLAIHLNRTANEGWAINPQNELPPILAQVAGDE---- 184
Query: 569 NSEQKDSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGIHQEFVFAPR 748
++ +L E +A+E ++ + ++D EL D Q + + G++ +F+ R
Sbjct: 185 ----------RIDFRALLTEQLAREHELIADVVLDYELSFYDTQDAALIGLNGDFIAGAR 234
Query: 749 LDNLFNCYTSVQALVESLESVSDDT 823
LDNL +CY +QAL L + SD+T
Sbjct: 235 LDNLLSCYAGLQAL---LAADSDET 256
>sp|Q9HYZ3|APEB_PSEAE Probable M18-family aminopeptidase 2
Length = 429
Score = 186 bits (473), Expect = 5e-47
Identities = 97/273 (35%), Positives = 156/273 (57%)
Frame = +2
Query: 23 KNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTIIALAI 202
+ LI F+ SPTP+HA AS+ L G++ + E+D W+ + +VT+N S++IA+ +
Sbjct: 7 QGLIDFLKASPTPFHATASLARRLEAAGYRRLDERDAWHTETGGRYYVTRNDSSLIAIRL 66
Query: 203 GGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRDLTVAG 382
G + +GF ++GAHTDSPCLR+KP E N +++LGVE YGG L+ WFDRDL++AG
Sbjct: 67 GRRSPLESGFRLVGAHTDSPCLRVKPNPEIARNGFLQLGVEVYGGALFAPWFDRDLSLAG 126
Query: 383 RCVVRESDKYRHLLVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPVLCTTIYEQIN 562
R R + K LV+ + IA IP LA+HL+R+ N+ + N + L P++
Sbjct: 127 RVTFRANGKLESRLVDFRKAIAVIPNLAIHLNRAANEGWPINAQNELPPIIAQL------ 180
Query: 563 KINSEQKDSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGIHQEFVFA 742
+P + + +L E + +E + + ++D EL D Q + + G++ EF+
Sbjct: 181 --------APGEAADFRLLLDEQLLREHGITADVVLDYELSFYDTQSAAVVGLNDEFIAG 232
Query: 743 PRLDNLFNCYTSVQALVESLESVSDDTNIRAVC 841
RLDNL +C+ ++AL+ + D N VC
Sbjct: 233 ARLDNLLSCHAGLEALL----NAEGDENCILVC 261
>sp|Q97LF4|APEB_CLOAB Probable M18-family aminopeptidase 2
Length = 433
Score = 184 bits (467), Expect = 3e-46
Identities = 106/278 (38%), Positives = 157/278 (56%), Gaps = 3/278 (1%)
Frame = +2
Query: 11 LNYAKNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTII 190
L +AK LI FI SP+P+H+V ++K+ L+ GF EI E+++W L N FV +N S +I
Sbjct: 5 LEFAKKLIDFIYDSPSPFHSVDNIKNTLIENGFAEIKEENKWELNKNGKYFVKRNDSALI 64
Query: 191 ALAIGGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLS-NTYMKLGVETYGGGLWYTWFDRD 367
A +G + GF +IG HTDSP R+KP E +S N+Y+KL E YGG + TWFDR
Sbjct: 65 AFTVGSGFVAKKGFKIIGGHTDSPTFRIKPNPEMVSENSYIKLNTEVYGGPILSTWFDRP 124
Query: 368 LTVAGRCVVRESDKY--RHLLVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPVLCT 541
L++AGR VR L+N+ RPI IP LA+H++R VN F N ++ P++
Sbjct: 125 LSIAGRVTVRGKSALFPETKLLNIKRPILVIPNLAIHMNRDVNSGFKINPQVDTLPII-G 183
Query: 542 TIYEQINKINSEQKDSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGI 721
I ++ K N L++ IA EL +E+I+D +L L + I GI
Sbjct: 184 IINDKFEKEN---------------YLMKIIASELGEDIENIIDFDLFLYEYDKGCIMGI 228
Query: 722 HQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNIRA 835
+ EF+ + RLD++ + + ALV + S+ TN+ A
Sbjct: 229 NNEFISSSRLDDMEMVHAGLNALVNA--KCSEATNVLA 264
>sp|Q87YC5|APEB_PSESM Probable M18-family aminopeptidase 2
Length = 429
Score = 180 bits (456), Expect = 5e-45
Identities = 96/267 (35%), Positives = 149/267 (55%)
Frame = +2
Query: 23 KNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTIIALAI 202
K LI F+ SPTP+HA A++ GF+ + E+D W ++ +VT+N S+I+A+ +
Sbjct: 7 KGLIDFLKASPTPFHATATLVQHFEAAGFQRLDERDTWAIETGGRYYVTRNDSSIVAIRM 66
Query: 203 GGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRDLTVAG 382
G + G M+GAHTDSPCLR+KP E + +LGVE YGG L WFDRDL++AG
Sbjct: 67 GRQSPLTGGIRMVGAHTDSPCLRVKPQPELQRQGFWQLGVEVYGGALLAPWFDRDLSLAG 126
Query: 383 RCVVRESDKYRHLLVNLHRPIARIPTLAVHLDRSVNDSFAPNKELHLNPVLCTTIYEQIN 562
R R K L++ PIA IP LA+HL+R+ N+ + N + L P+L ++
Sbjct: 127 RVTFRRDGKVESQLIDFKLPIAVIPNLAIHLNRTANEGWTINPQNELPPILAQVAGDE-- 184
Query: 563 KINSEQKDSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGIHQEFVFA 742
+ +L + +A+E + + ++D EL D Q + + G++ +F+
Sbjct: 185 ------------RADFRALLTDQLAREHGLNADVVLDYELSFYDTQSAAVVGLNGDFLAG 232
Query: 743 PRLDNLFNCYTSVQALVESLESVSDDT 823
RLDNL +C+ +QAL L + SD+T
Sbjct: 233 ARLDNLLSCFAGMQAL---LNTESDET 256
>sp|Q82F74|APEB_STRAW Probable M18-family aminopeptidase 2
Length = 432
Score = 128 bits (322), Expect = 2e-29
Identities = 80/259 (30%), Positives = 129/259 (49%), Gaps = 1/259 (0%)
Frame = +2
Query: 17 YAKNLIKFIDKSPTPYHAVASVKDMLVNYGFKEIHEQDEWNLKPNDLVFVTKNHSTIIAL 196
+ +L+ F+ SP+PYHAV + + L GF+++ E D W+ V +IA
Sbjct: 11 HTDDLMSFLAASPSPYHAVTNAAERLEKAGFRQVAETDAWDSTSGGKYVV--RGGALIAW 68
Query: 197 AIGGKYKPGNGFSMIGAHTDSPCLRLKPCSEQLSNTYMKLGVETYGGGLWYTWFDRDLTV 376
+ P F ++GAHTDSP LR+KP + ++ + ++ VE YGG L +W DRDL +
Sbjct: 69 YVPEGADPHTPFRIVGAHTDSPNLRVKPRPDSGAHGWRQIAVEIYGGPLLNSWLDRDLGL 128
Query: 377 AGRCVVRESDKYRHLLVNLHRPIARIPTLAVHLDRSVN-DSFAPNKELHLNPVLCTTIYE 553
AGR +R+ LVN+ RP+ R+P LA+HLDRSV+ D +K+ HL P+
Sbjct: 129 AGRLSLRDGST---RLVNIDRPLLRVPQLAIHLDRSVSTDGLKLDKQRHLQPIW------ 179
Query: 554 QINKINSEQKDSPTSSLNHPTVLLEAIAQELKVKVEDIVDVELCLADCQPSTIGGIHQEF 733
+ + +D L+ + EL + ++ +L + + G E
Sbjct: 180 ---GLGGDVRDGD---------LIAFLEAELGLSAGEVTGWDLMTHSVEAPSYLGRDNEL 227
Query: 734 VFAPRLDNLFNCYTSVQAL 790
+ PR+DNL + + AL
Sbjct: 228 LAGPRMDNLLSVHAGTAAL 246
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,874,170
Number of Sequences: 369166
Number of extensions: 2095579
Number of successful extensions: 5235
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5006
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5199
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)