Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_B07
(756 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P51893|SAHHA_XENLA Adenosylhomocysteinase A (S-adenosyl-... 419 e-117
sp|O93477|SAHHB_XENLA Adenosylhomocysteinase B (S-adenosyl-... 418 e-117
sp|P50247|SAHH_MOUSE Adenosylhomocysteinase (S-adenosyl-L-h... 411 e-114
sp|P23526|SAHH_HUMAN Adenosylhomocysteinase (S-adenosyl-L-h... 410 e-114
sp|P10760|SAHH_RAT Adenosylhomocysteinase (S-adenosyl-L-hom... 406 e-113
sp|Q710C4|SAHH_PIG Adenosylhomocysteinase (S-adenosyl-L-hom... 406 e-113
sp|Q27580|SAHH_DROME Adenosylhomocysteinase (S-adenosyl-L-h... 399 e-111
sp|P27604|SAHH_CAEEL Adenosylhomocysteinase (S-adenosyl-L-h... 397 e-110
sp|O76757|SAHH_ANOGA Adenosylhomocysteinase (S-adenosyl-L-h... 382 e-106
sp|O13639|SAHH_SCHPO Adenosylhomocysteinase (S-adenosyl-L-h... 381 e-105
>sp|P51893|SAHHA_XENLA Adenosylhomocysteinase A (S-adenosyl-L-homocysteine hydrolase A)
(AdoHcyase A)
Length = 433
Score = 419 bits (1077), Expect = e-117
Identities = 202/246 (82%), Positives = 221/246 (89%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QT+YF++G+PLNMILDDGGDLTNLVH KYP LL GIKGISEETTTGVHNLYKM SSG L+
Sbjct: 116 QTIYFKDGKPLNMILDDGGDLTNLVHSKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQ 175
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALRA
Sbjct: 176 VPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRA 235
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RV+++EIDPINALQAAMEGYEVT+++EA K+ IFVT TGC DI+ GRHFE M DDS
Sbjct: 236 FGARVIITEIDPINALQAAMEGYEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDS 295
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFDIE++ KWL EN K IKPQVDRY LKNGRHIILLAEGRLVNLGCA GHP
Sbjct: 296 IVCNIGHFDIELDVKWLNENAVKKVNIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHP 355
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 356 SFVMSN 361
>sp|O93477|SAHHB_XENLA Adenosylhomocysteinase B (S-adenosyl-L-homocysteine hydrolase B)
(AdoHcyase B)
Length = 433
Score = 418 bits (1075), Expect = e-117
Identities = 201/246 (81%), Positives = 221/246 (89%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QT+YF++G+PLNMILDDGGDLTNLVH KYP LL GIKGISEETTTGVHNLYKM SSG L+
Sbjct: 116 QTIYFKDGKPLNMILDDGGDLTNLVHTKYPQLLKGIKGISEETTTGVHNLYKMKSSGTLQ 175
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALRA
Sbjct: 176 VPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRA 235
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RVL++EIDPINALQAAMEGYEVT+++EA K+ IFVT TGC DI+ GRHFE M DDS
Sbjct: 236 FGARVLITEIDPINALQAAMEGYEVTTMDEASKEGNIFVTTTGCADIVEGRHFENMKDDS 295
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFD+E++ KWL +N K IKPQVDRY LKNGRHIILLAEGRLVNLGCA GHP
Sbjct: 296 IVCNIGHFDVELDVKWLNDNAAKKINIKPQVDRYLLKNGRHIILLAEGRLVNLGCAMGHP 355
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 356 SFVMSN 361
>sp|P50247|SAHH_MOUSE Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase) (Liver copper binding protein) (CUBP)
Length = 432
Score = 411 bits (1056), Expect = e-114
Identities = 199/246 (80%), Positives = 221/246 (89%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QTL+F++G PLNMILDDGGDLTNL+H KYP LL GI+GISEETTTGVHNLYKMMS+G LK
Sbjct: 116 QTLHFKDG-PLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMSNGILK 174
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR
Sbjct: 175 VPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRG 234
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RV+++EIDPINALQAAMEGYEVT+++EA K+ IFVT TGC DII+GRHFEQM DD+
Sbjct: 235 FGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDA 294
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFD+E++ KWL EN K IKPQVDRY LKNGR IILLAEGRLVNLGCA GHP
Sbjct: 295 IVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHP 354
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 355 SFVMSN 360
>sp|P23526|SAHH_HUMAN Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 410 bits (1053), Expect = e-114
Identities = 198/246 (80%), Positives = 221/246 (89%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QTLYF++G PLNMILDDGGDLTNL+H KYP LL GI+GISEETTTGVHNLYKMM++G LK
Sbjct: 116 QTLYFKDG-PLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILK 174
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR
Sbjct: 175 VPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRG 234
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RV+++EIDPINALQAAMEGYEVT+++EA ++ IFVT TGC DII+GRHFEQM DD+
Sbjct: 235 FGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDA 294
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFD+E++ KWL EN K IKPQVDRY LKNGR IILLAEGRLVNLGCA GHP
Sbjct: 295 IVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHP 354
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 355 SFVMSN 360
>sp|P10760|SAHH_RAT Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 406 bits (1044), Expect = e-113
Identities = 196/246 (79%), Positives = 220/246 (89%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QTL+F++G PLNMILDDGGDLTNL+H K+P LL GI+GISEETTTGVHNLYKMM++G LK
Sbjct: 116 QTLHFKDG-PLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILK 174
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR
Sbjct: 175 VPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRG 234
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RV+++EIDPINALQAAMEGYEVT+++EA K+ IFVT TGC DII+GRHFEQM DD+
Sbjct: 235 FGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDA 294
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFD+E++ KWL EN K IKPQVDRY LKNG IILLAEGRLVNLGCA GHP
Sbjct: 295 IVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHP 354
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 355 SFVMSN 360
>sp|Q710C4|SAHH_PIG Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 406 bits (1044), Expect = e-113
Identities = 197/246 (80%), Positives = 219/246 (89%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QTLYF++G PLNMILDDGGDLTNLVH KYP LL GI+GISEETTTGVHNLYKM ++G LK
Sbjct: 116 QTLYFKDG-PLNMILDDGGDLTNLVHTKYPELLSGIRGISEETTTGVHNLYKMKANGILK 174
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKVA+VAGYGDVGKGC QALR
Sbjct: 175 VPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRG 234
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RV+++EIDPINALQAAMEGYEVT+++EA ++ IFVT TGC DII+GRHFEQM DD+
Sbjct: 235 FGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDA 294
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFD+E++ KWL EN K IKPQVDRY LKNG IILLAEGRLVNLGCA GHP
Sbjct: 295 IVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHP 354
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 355 SFVMSN 360
>sp|Q27580|SAHH_DROME Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 399 bits (1024), Expect = e-111
Identities = 190/246 (77%), Positives = 214/246 (86%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QTL F +GQPLNMILDDGGDLTNLVHEK+P L IKG+SEETTTGVHNLYKM G+L
Sbjct: 115 QTLVFPDGQPLNMILDDGGDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLG 174
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKV VAGYGDVGKGC QAL+
Sbjct: 175 VPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKG 234
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RV+V+E+DPINALQAAMEGYEVT++EEA K+A IFVT TGC+DII H +QM DD+
Sbjct: 235 FGGRVIVTEVDPINALQAAMEGYEVTTMEEASKEASIFVTTTGCRDIITSVHLQQMPDDA 294
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFDIE++ WL N K K +KPQVDRYT+++G+HIILLAEGRLVNLGCAHGHP
Sbjct: 295 IVCNIGHFDIEIDVDWLNANAKEKVNVKPQVDRYTMQSGKHIILLAEGRLVNLGCAHGHP 354
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 355 SFVMSN 360
>sp|P27604|SAHH_CAEEL Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase) (Dumpy-14 protein)
Length = 437
Score = 397 bits (1019), Expect = e-110
Identities = 191/246 (77%), Positives = 215/246 (87%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QT+ F++GQPLNMILDDGGDLTNLVH KYP L GI+G+SEETTTGVHNL KM++ G LK
Sbjct: 117 QTIVFKDGQPLNMILDDGGDLTNLVHAKYPQYLAGIRGLSEETTTGVHNLAKMLAKGDLK 176
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYG RESL DGIKRATDVMLAGKVA+VAGYGDVGKG +L+A
Sbjct: 177 VPAINVNDSVTKSKFDNLYGIRESLPDGIKRATDVMLAGKVAVVAGYGDVGKGSAASLKA 236
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
+G RV+V+EIDPINALQAAMEGYEVT++EEA KA I VT TGCKDI+ G+HFE + +D+
Sbjct: 237 FGSRVIVTEIDPINALQAAMEGYEVTTLEEAAPKANIIVTTTGCKDIVTGKHFELLPNDA 296
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCN+GHFD E++ KWL N KDTIKPQVDRYTLKNGRH+ILLAEGRLVNLGCA GHP
Sbjct: 297 IVCNVGHFDCEIDVKWLNTNATKKDTIKPQVDRYTLKNGRHVILLAEGRLVNLGCATGHP 356
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 357 SFVMSN 362
>sp|O76757|SAHH_ANOGA Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 432
Score = 382 bits (981), Expect = e-106
Identities = 189/246 (76%), Positives = 207/246 (84%)
Frame = +2
Query: 17 QTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGKLK 196
QTL F +G+PLNMILDDGGDLTNLVH ++P LL I+G+SEETTTGVHNLYKM G+L
Sbjct: 115 QTLIFPDGKPLNMILDDGGDLTNLVHAEHPELLKEIRGLSEETTTGVHNLYKMFREGRLG 174
Query: 197 CPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQALRA 376
PAINVNDSVTKSKFDNLYGCRESL+DGIKRATDVM+AGKV +VAGYGDVGKGC QALR
Sbjct: 175 MPAINVNDSVTKSKFDNLYGCRESLLDGIKRATDVMIAGKVCVVAGYGDVGKGCAQALRG 234
Query: 377 YGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLDDS 556
G RVL++EIDPINALQAAMEG EVT++EEA K+A+IFVT TGC DII+G HF M DDS
Sbjct: 235 SGGRVLITEIDPINALQAAMEGKEVTTMEEASKEAQIFVTTTGCTDIIMGEHFLNMKDDS 294
Query: 557 IVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHGHP 736
IVCNIGHFD E+ WL EN K IKPQVDRY L NG HIILLAEGRLVNLGCA GH
Sbjct: 295 IVCNIGHFDCEINVTWLQENAVEKVNIKPQVDRYRLANGNHIILLAEGRLVNLGCAMGHS 354
Query: 737 SFVMSN 754
SFVMSN
Sbjct: 355 SFVMSN 360
>sp|O13639|SAHH_SCHPO Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase)
(AdoHcyase)
Length = 433
Score = 381 bits (978), Expect = e-105
Identities = 184/247 (74%), Positives = 212/247 (85%)
Frame = +2
Query: 11 EGQTLYFRNGQPLNMILDDGGDLTNLVHEKYPHLLDGIKGISEETTTGVHNLYKMMSSGK 190
E Q F +G+PLNMILDDGGDLT LVHE++P LL I+GISEETTTGVHNLYKM K
Sbjct: 114 EQQLKSFPSGKPLNMILDDGGDLTALVHERHPELLVDIRGISEETTTGVHNLYKMFKENK 173
Query: 191 LKCPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVALVAGYGDVGKGCCQAL 370
LK PAINVNDSVTKSKFDNL+GC+ESLVDGIKRATDVM+AGKVA+VAG+GDVGKGC +L
Sbjct: 174 LKVPAINVNDSVTKSKFDNLFGCKESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCSTSL 233
Query: 371 RAYGCRVLVSEIDPINALQAAMEGYEVTSVEEAVKKARIFVTATGCKDIIVGRHFEQMLD 550
R+ G RV+V+E+DPINALQAAM+G+EVT++EEAVK+ +IFVT TGC+DII G HF +M +
Sbjct: 234 RSQGARVIVTEVDPINALQAAMDGFEVTTMEEAVKEGQIFVTTTGCRDIIRGEHFNEMKE 293
Query: 551 DSIVCNIGHFDIEVEAKWLYENCKSKDTIKPQVDRYTLKNGRHIILLAEGRLVNLGCAHG 730
DSIVCNIGHFD+E++ WL N K IKPQVDRY LKNGRHIILLA+GRLVNLGCA G
Sbjct: 294 DSIVCNIGHFDVEIDVAWLKANAKDVVNIKPQVDRYELKNGRHIILLADGRLVNLGCATG 353
Query: 731 HPSFVMS 751
HPSFVMS
Sbjct: 354 HPSFVMS 360
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 87,208,243
Number of Sequences: 369166
Number of extensions: 1708513
Number of successful extensions: 5292
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5030
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5213
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6921714800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)