Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_A21
(829 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 49 2e-05
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 48 4e-05
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 47 6e-05
sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-bindi... 45 2e-04
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 45 3e-04
sp|O70263|LNX1_MOUSE Ubiquitin ligase LNX (Numb-binding pro... 43 0.001
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 43 0.001
sp|Q91XL2|LNX2_MOUSE Ligand of Numb-protein X 2 (Numb-bindi... 43 0.001
sp|Q8TBB1|LNX1_HUMAN Ubiquitin ligase LNX (Numb-binding pro... 41 0.004
sp|Q69ZS0|PZRN3_MOUSE PDZ domain-containing RING finger pro... 41 0.004
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/99 (28%), Positives = 43/99 (43%)
Frame = +2
Query: 116 YKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXXXXXXIAPNHIKN 295
Y+C IC L A Q CG FC CI + + + + P++
Sbjct: 68 YECPICLMALREAVQTPCGHRFCKACIIKSIRDAG---HKCPVDNEILLENQLFPDNFAK 124
Query: 296 KLISKLIVRCSNEMCSHECQLIEMENHLNSCLNKAVKCP 412
+ I L+V+C NE C H+ +L +E+H C + CP
Sbjct: 125 REILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCP 163
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 47.8 bits (112), Expect = 4e-05
Identities = 27/111 (24%), Positives = 46/111 (41%), Gaps = 1/111 (0%)
Frame = +2
Query: 83 KFTIIGDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXXX 262
++ + + + YKC C ++L N HQ CG FC +CI ++
Sbjct: 32 EYQFVEQLEERYKCAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSV--PICPVDKEVIK 89
Query: 263 XXXIAPNHIKNKLISKLIVRCSNEM-CSHECQLIEMENHLNSCLNKAVKCP 412
+ ++ + + L V C N C+ L ++HL C +AV CP
Sbjct: 90 PQEVFKDNCCKREVLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCP 140
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 47.0 bits (110), Expect = 6e-05
Identities = 32/133 (24%), Positives = 56/133 (42%), Gaps = 1/133 (0%)
Frame = +2
Query: 83 KFTIIGDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXXX 262
++ + + + YKC C ++L N HQ CG FC CI +
Sbjct: 32 EYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTV--PICPVDKEVIK 89
Query: 263 XXXIAPNHIKNKLISKLIVRCSNEM-CSHECQLIEMENHLNSCLNKAVKCPFNDVGCEHG 439
+ ++ + + L V CSN C+ + L ++HL CL + V+C ++ C
Sbjct: 90 SQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQC--SNEKCRE- 146
Query: 440 DVINDKLNDHMLA 478
V+ L +H+ A
Sbjct: 147 PVLRKDLKEHLSA 159
Score = 30.8 bits (68), Expect = 4.8
Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 3/80 (3%)
Frame = +2
Query: 281 NHIKNKLISKLIVRCSNEMCSHECQLIEMENHLNSCLNKAVKCPFNDVGCEHGDVINDK- 457
NH +N L + V C N C+ E++ HL C CPF GC + DK
Sbjct: 182 NHEEN-LCPEYPVFCPNN-CAKIILKTEVDEHLAVCPEAEQDCPFKHYGC----AVTDKR 235
Query: 458 --LNDHMLADIHNHNKILID 511
L H + + H +++++
Sbjct: 236 RNLQQHEHSALREHMRLVLE 255
>sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ
domain-containing RING finger protein 1)
Length = 690
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/141 (24%), Positives = 56/141 (39%), Gaps = 2/141 (1%)
Frame = +2
Query: 80 HKFTIIGDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXX 259
H + +V+DD C IC L+ CG FCY+C+ ++
Sbjct: 36 HLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKL 95
Query: 260 XXXXIAPNHIKNKLISKLIVRCS-NEMCSHECQLIEMENHLNSCLNKAVKCPFNDVGCEH 436
+ + +KL+ KL+V C + +C Q ++E HL + +CP G H
Sbjct: 96 CK---KSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKN------RCP----GASH 142
Query: 437 GDV-INDKLNDHMLADIHNHN 496
V + + A+I N N
Sbjct: 143 RRVALERRKTSRTQAEIENEN 163
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/99 (27%), Positives = 41/99 (41%)
Frame = +2
Query: 116 YKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXXXXXXIAPNHIKN 295
Y+C IC L A Q CG FC CI + + + + P++
Sbjct: 68 YECPICLMALREAVQTPCGHRFCKACIIKSIRDAG---HKCPVDNEILLENQLFPDNFAK 124
Query: 296 KLISKLIVRCSNEMCSHECQLIEMENHLNSCLNKAVKCP 412
+ I L V+C N+ C + +L +E+H C V CP
Sbjct: 125 REILSLTVKCPNKGCLQKMELRHLEDHQVHCEFALVNCP 163
>sp|O70263|LNX1_MOUSE Ubiquitin ligase LNX (Numb-binding protein 1) (Ligand of
Numb-binding protein 1) (Ligand of Numb-protein X 1)
Length = 728
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/109 (24%), Positives = 45/109 (41%), Gaps = 7/109 (6%)
Frame = +2
Query: 80 HKFTIIGDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXX 259
H +T DV+DD C IC L++ CG +C C+ ++
Sbjct: 31 HFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVE---------KDFCPV 81
Query: 260 XXXXIAPNHIK------NKLISKLIVRCS-NEMCSHECQLIEMENHLNS 385
+ H K NKL++KL+V C E C+ Q ++++H +
Sbjct: 82 DRKPVVLQHCKKSSILVNKLLNKLLVTCPFTEHCTEVLQRCDLQHHFQT 130
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/137 (24%), Positives = 56/137 (40%), Gaps = 6/137 (4%)
Frame = +2
Query: 80 HKFTIIGDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXX 259
+K + V D YKC C+ +L N Q CG FC C+ +++ +
Sbjct: 38 YKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSS--PKCTACQESII 95
Query: 260 XXXXIAPNHIKNKLISKLIVRCSNE--MCSHECQLIEMENHLNSCLNKAVKCPFNDVGCE 433
N K ++++ L V C NE C+ + L + HL + +C F ++ C
Sbjct: 96 KDKVFKDNCCKREILA-LQVYCRNEGRGCAEQLTLGHLLVHLKN------ECQFEELPCL 148
Query: 434 HGD----VINDKLNDHM 472
D V+ L DH+
Sbjct: 149 RADCKEKVLRKDLRDHV 165
Score = 30.4 bits (67), Expect = 6.2
Identities = 17/66 (25%), Positives = 26/66 (39%), Gaps = 5/66 (7%)
Frame = +2
Query: 323 CSNEMCSHECQL-----IEMENHLNSCLNKAVKCPFNDVGCEHGDVINDKLNDHMLADIH 487
C C H+C + E+ HL+ C+N C F GC N ++ H +
Sbjct: 198 CVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGT-NQQIKAHEASSAV 256
Query: 488 NHNKIL 505
H +L
Sbjct: 257 QHVNLL 262
>sp|Q91XL2|LNX2_MOUSE Ligand of Numb-protein X 2 (Numb-binding protein 2)
Length = 687
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 2/105 (1%)
Frame = +2
Query: 80 HKFTIIGDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXX 259
H + G+V+DD C IC L+ CG FC++C+ ++
Sbjct: 37 HLYNYQGEVDDDLVCHICLQPLLQPLDTPCGHTFCHKCLRNFLQEKDFCPLDRKRLHFKL 96
Query: 260 XXXXIAPNHIKNKLISKLIVRCS-NEMCSHECQLIEMENHL-NSC 388
+ + +KL+ KL+V C + +C Q ++E HL N C
Sbjct: 97 CK---KSSILVHKLLDKLLVLCPFSPVCQDVMQRCDLEAHLKNRC 138
>sp|Q8TBB1|LNX1_HUMAN Ubiquitin ligase LNX (Numb-binding protein 1) (Ligand of
Numb-protein X 1)
Length = 728
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/109 (22%), Positives = 46/109 (42%), Gaps = 1/109 (0%)
Frame = +2
Query: 62 YKLISQHKFTIIGDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXX 241
+ L H ++ +V+DD C IC L++ CG +C C+ ++
Sbjct: 21 HSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRK 80
Query: 242 XXXXXXXXXXIAPNHIKNKLISKLIVRCS-NEMCSHECQLIEMENHLNS 385
+ + NKL++KL+V C E C+ Q ++E+H +
Sbjct: 81 PLVLQHCK---KSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQT 126
>sp|Q69ZS0|PZRN3_MOUSE PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic
domain-associated protein 3) (SEMACAP3 protein)
Length = 1063
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/113 (23%), Positives = 44/113 (38%), Gaps = 2/113 (1%)
Frame = +2
Query: 98 GDVNDDYKCVICKNILINAHQAICGCNFCYECINQYMANGAIXXXXXXXXXXXXXXXXIA 277
GDV+ D KC +C +L + CG FC C+ ++ +
Sbjct: 10 GDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVL 69
Query: 278 PNHIKNKLISKLIVRCSNEM--CSHECQLIEMENHLNSCLNKAVKCPFNDVGC 430
P +LI KL ++C++ C +L ++ HL C +C GC
Sbjct: 70 P---LKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARC--RHAGC 117
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,409,743
Number of Sequences: 369166
Number of extensions: 1454605
Number of successful extensions: 3750
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3586
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3735
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)