Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_A13
(601 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitoc... 269 3e-72
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 268 8e-72
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 268 8e-72
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 249 4e-66
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 247 2e-65
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 247 2e-65
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplas... 246 2e-65
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 245 7e-65
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytopl... 244 1e-64
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 231 8e-61
>sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 269 bits (688), Expect = 3e-72
Identities = 128/161 (79%), Positives = 142/161 (88%), Gaps = 1/161 (0%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAH
Sbjct: 289 LIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAH 348
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ ++E+ CV+TV+S
Sbjct: 349 GTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVES 408
Query: 374 GKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 493
G MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 409 GAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 268 bits (685), Expect = 8e-72
Identities = 128/161 (79%), Positives = 141/161 (87%), Gaps = 1/161 (0%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAH
Sbjct: 289 LIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAH 348
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV+TV+S
Sbjct: 349 GTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVES 408
Query: 374 GKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 493
G MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 409 GAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 421
Score = 268 bits (685), Expect = 8e-72
Identities = 128/161 (79%), Positives = 141/161 (87%), Gaps = 1/161 (0%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIEAEAAH
Sbjct: 258 LIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAH 317
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV+TV+S
Sbjct: 318 GTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCVETVES 377
Query: 374 GKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 493
G MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 378 GAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 523
Score = 249 bits (636), Expect = 4e-66
Identities = 123/161 (76%), Positives = 134/161 (83%), Gaps = 1/161 (0%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+A +GSLGLMTSVL+CPDGKTIEAEAAH
Sbjct: 361 LIDDMVAQVLKSSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLVCPDGKTIEAEAAH 420
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYREHQKG+PTST IASIFAWTRGLEHRGKLD NQ+LIR+ E+ CV TV+
Sbjct: 421 GTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFAQTREKVCVQTVE- 479
Query: 374 GKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 493
G MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 480 GAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 520
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 247 bits (630), Expect = 2e-65
Identities = 114/160 (71%), Positives = 135/160 (84%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAH
Sbjct: 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAH 309
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E C++T+++
Sbjct: 310 GTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIETIEA 369
Query: 374 GKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 493
G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 370 GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 247 bits (630), Expect = 2e-65
Identities = 114/160 (71%), Positives = 135/160 (84%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAH
Sbjct: 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAH 309
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E C++T+++
Sbjct: 310 GTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIETIEA 369
Query: 374 GKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 493
G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 370 GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 246 bits (629), Expect = 2e-65
Identities = 114/160 (71%), Positives = 136/160 (85%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAH
Sbjct: 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAH 309
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN EL + + +E C++T+++
Sbjct: 310 GTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIETIEA 369
Query: 374 GKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 493
G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 370 GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 245 bits (625), Expect = 7e-65
Identities = 114/160 (71%), Positives = 135/160 (84%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAH
Sbjct: 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAH 309
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN EL + +E C++T+++
Sbjct: 310 GTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEA 369
Query: 374 GKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 493
G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 370 GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 244 bits (623), Expect = 1e-64
Identities = 114/160 (71%), Positives = 135/160 (84%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EAEAAH
Sbjct: 250 LIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAH 309
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLDNN+EL + + +E ++T+++
Sbjct: 310 GTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEA 369
Query: 374 GKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 493
G MTKDLAACI GL NVQ + YL T +F+D + EN + KL
Sbjct: 370 GFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKL 409
>sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase)
(IDH) (NADP(+)-specific ICDH) (IDP)
Length = 415
Score = 231 bits (590), Expect = 8e-61
Identities = 111/160 (69%), Positives = 130/160 (81%)
Frame = +2
Query: 14 LIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEAEAAH 193
LIDDM A ALKS GG+VW CKNYDGDVQSD +AQG+GSLGLMTSVL+CPDGKTIEAEAAH
Sbjct: 252 LIDDMAAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAH 311
Query: 194 GTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVDTVDS 373
GTVTRHYR HQKG TSTN IASIFAWTRGL HR LDNN+ L+ + +E AC+ V+S
Sbjct: 312 GTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFTEKLEAACIGAVES 371
Query: 374 GKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 493
GKMTKDLA IHG K + +HYL T +F+DA+A+ +++L
Sbjct: 372 GKMTKDLALIIHGSK-LSRDHYLNTEEFIDAVADELKARL 410
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,199,567
Number of Sequences: 369166
Number of extensions: 1518584
Number of successful extensions: 3726
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3621
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3711
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4602033670
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)