Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_A10
(639 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8IU80|TMPS6_HUMAN Transmembrane protease, serine 6 (Mat... 70 6e-12
sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Mat... 68 2e-11
sp|Q867B0|ELA1_CANFA Elastase-1 precursor 68 2e-11
sp|P08419|ELA2_PIG Elastase-2 precursor 68 2e-11
sp|P06868|PLMN_BOVIN Plasminogen precursor [Contains: Plasm... 67 3e-11
sp|P05208|ELA2_MOUSE Elastase-2 precursor 67 4e-11
sp|Q9UNI1|ELA1_HUMAN Elastase-1 precursor 67 5e-11
sp|Q29485|PLMN_ERIEU Plasminogen precursor [Contains: Plasm... 67 5e-11
sp|O46644|ELA1_MACFA Elastase-1 precursor 65 1e-10
sp|P16296|FA9_RAT Coagulation factor IX (Christmas factor) 63 6e-10
>sp|Q8IU80|TMPS6_HUMAN Transmembrane protease, serine 6 (Matriptase-2)
Length = 802
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/192 (26%), Positives = 86/192 (44%)
Frame = +3
Query: 18 NVRKRSIYICGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDH 197
+++ R +ICGG LI WV+TAAHC + ++V L+ F + +
Sbjct: 584 SLQVRGRHICGGALIADRWVITAAHCFQEDSMASTV------------LWTVFLGKVWQN 631
Query: 198 DRTTDDADEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVK 377
R E+S K+S +++P D S+ YD+ALL+LD PV+ S V P +
Sbjct: 632 SRW---PGEVSFKVSRLLLHPYHEED--SHDYDVALLQLDHPVVRSAAVR---PVCLPAR 683
Query: 378 NYTLDKSAKCYAIGWGNIEQNEPYNIWSFEFDFVLERWRKNKSHKNSNILQEVEIPLVNF 557
++ + C+ GWG + + P SN LQ+V++ L+
Sbjct: 684 SHFFEPGLHCWITGWGALREGGPI----------------------SNALQKVDVQLIPQ 721
Query: 558 ELCQKDIEYLIS 593
+LC + Y ++
Sbjct: 722 DLCSEVYRYQVT 733
>sp|Q9DBI0|TMPS6_MOUSE Transmembrane protease, serine 6 (Matriptase-2)
Length = 799
Score = 68.2 bits (165), Expect = 2e-11
Identities = 53/192 (27%), Positives = 81/192 (42%), Gaps = 4/192 (2%)
Frame = +3
Query: 30 RSIYICGGTLINPGWVVTAAHCLKTIEAVN----SVPLGEMIDTRKYDLYDKFHVVINDH 197
R +ICGG LI WV+TAAHC + + +V LG+M ++
Sbjct: 585 RGRHICGGALIADRWVITAAHCFQEDSMASPKLWTVFLGKMRQNSRW------------- 631
Query: 198 DRTTDDADEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVK 377
E+S K+S ++P D S+ YD+ALL+LD PV+ S V P +
Sbjct: 632 ------PGEVSFKVSRLFLHPYHEED--SHDYDVALLQLDHPVVYSATVR---PVCLPAR 680
Query: 378 NYTLDKSAKCYAIGWGNIEQNEPYNIWSFEFDFVLERWRKNKSHKNSNILQEVEIPLVNF 557
++ + C+ GWG + P SN LQ+V++ LV
Sbjct: 681 SHFFEPGQHCWITGWGAQREGGPV----------------------SNTLQKVDVQLVPQ 718
Query: 558 ELCQKDIEYLIS 593
+LC + Y +S
Sbjct: 719 DLCSEAYRYQVS 730
>sp|Q867B0|ELA1_CANFA Elastase-1 precursor
Length = 258
Score = 68.2 bits (165), Expect = 2e-11
Identities = 49/188 (26%), Positives = 82/188 (43%)
Frame = +3
Query: 39 YICGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDA 218
+ CGGTLI WV+TAAHC+ D F VVI +H+ + +D
Sbjct: 46 HTCGGTLIRQNWVMTAAHCV--------------------DRTMTFRVVIGEHNLSQNDG 85
Query: 219 DEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVKNYTLDKS 398
E S + +++P + ++ S YDIALL+L + V + V + +PQ + L +
Sbjct: 86 TEQSASVQKIVVHPYWNSNDVSAGYDIALLRLAQKVTLNSYVQLG--VLPQ-EGAILANN 142
Query: 399 AKCYAIGWGNIEQNEPYNIWSFEFDFVLERWRKNKSHKNSNILQEVEIPLVNFELCQKDI 578
+ CY GWG + N + + +LQ+ +P V++ +C
Sbjct: 143 SPCYITGWGLTKTN----------------------GQLAQVLQQAYLPTVDYAICSSSS 180
Query: 579 EYLISIKK 602
+ +KK
Sbjct: 181 YWGSIVKK 188
>sp|P08419|ELA2_PIG Elastase-2 precursor
Length = 269
Score = 67.8 bits (164), Expect = 2e-11
Identities = 40/134 (29%), Positives = 64/134 (47%)
Frame = +3
Query: 39 YICGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDA 218
+ CGGTL++ WV+TAAHC+ + + VV+ H +T++
Sbjct: 56 HTCGGTLVDQSWVLTAAHCISSSRT--------------------YRVVLGRHSLSTNEP 95
Query: 219 DEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVKNYTLDKS 398
++ K+S +++ + ++ SN DIALLKL PV S I C+P L +
Sbjct: 96 GSLAVKVSKLVVHQDWNSNQLSNGNDIALLKLASPV--SLTDKIQLGCLP-AAGTILPNN 152
Query: 399 AKCYAIGWGNIEQN 440
CY GWG ++ N
Sbjct: 153 YVCYVTGWGRLQTN 166
>sp|P06868|PLMN_BOVIN Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin light
chain B]
Length = 812
Score = 67.4 bits (163), Expect = 3e-11
Identities = 51/191 (26%), Positives = 84/191 (43%)
Frame = +3
Query: 15 VNVRKRSIYICGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVIND 194
V++R+ S + CGGTLI+P WV+TAAHCL I A++ + V++
Sbjct: 599 VSLRRSSRHFCGGTLISPKWVLTAAHCLDNILALSF-----------------YKVILGA 641
Query: 195 HDRTTDDADEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQV 374
H+ + + + ++ LFR + DIALLKL +P I +K V P
Sbjct: 642 HNEKVRE-----QSVQEIPVSRLFREPSQA---DIALLKLSRPAIITKEV---IPACLPP 690
Query: 375 KNYTLDKSAKCYAIGWGNIEQNEPYNIWSFEFDFVLERWRKNKSHKNSNILQEVEIPLVN 554
NY + +CY GWG + + +L+E +P++
Sbjct: 691 PNYMVAARTECYITGWG-----------------------ETQGTFGEGLLKEAHLPVIE 727
Query: 555 FELCQKDIEYL 587
++C ++ EYL
Sbjct: 728 NKVCNRN-EYL 737
>sp|P05208|ELA2_MOUSE Elastase-2 precursor
Length = 271
Score = 67.0 bits (162), Expect = 4e-11
Identities = 40/132 (30%), Positives = 61/132 (46%)
Frame = +3
Query: 45 CGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADE 224
CGG+L+ WV+TAAHCL Y + V++ H + A
Sbjct: 60 CGGSLVANNWVLTAAHCLSN--------------------YQTYRVLLGAHSLSNPGAGS 99
Query: 225 ISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVKNYTLDKSAK 404
+ ++S +++ + + N YDIAL+KL PV SK NI C+P L ++
Sbjct: 100 AAVQVSKLVVHQRWNSQNVGNGYDIALIKLASPVTLSK--NIQTACLPPA-GTILPRNYV 156
Query: 405 CYAIGWGNIEQN 440
CY GWG ++ N
Sbjct: 157 CYVTGWGLLQTN 168
>sp|Q9UNI1|ELA1_HUMAN Elastase-1 precursor
Length = 258
Score = 66.6 bits (161), Expect = 5e-11
Identities = 41/134 (30%), Positives = 63/134 (47%)
Frame = +3
Query: 39 YICGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDA 218
+ CGGTLI WV+TAAHC+ D F VV DH+ + +D
Sbjct: 46 HTCGGTLIRQNWVMTAAHCV--------------------DYQKTFRVVAGDHNLSQNDG 85
Query: 219 DEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVKNYTLDKS 398
E + +++P + +D + YDIALL+L + V + V + +PQ + L +
Sbjct: 86 TEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLG--VLPQ-EGAILANN 142
Query: 399 AKCYAIGWGNIEQN 440
+ CY GWG + N
Sbjct: 143 SPCYITGWGKTKTN 156
>sp|Q29485|PLMN_ERIEU Plasminogen precursor [Contains: Plasmin heavy chain A; Activation
peptide; Plasmin heavy chain A, short form; Plasmin light
chain B]
Length = 810
Score = 66.6 bits (161), Expect = 5e-11
Identities = 51/187 (27%), Positives = 83/187 (44%), Gaps = 1/187 (0%)
Frame = +3
Query: 15 VNVRKRSIYICGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVIND 194
V++R+ + CGGTLI+P WVVTAAHCL+ K+ + VV+
Sbjct: 597 VSLRRFGQHFCGGTLISPEWVVTAAHCLE-----------------KFSNPAIYKVVLGA 639
Query: 195 HDRTTDDADEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFP-CVPQ 371
H T + D + ++ + P +RA DIALLKL P I + + + P C+P
Sbjct: 640 HQETRLERDVQIKGVTKMFLEP-YRA-------DIALLKLSSPAI---ITDKDHPACLPN 688
Query: 372 VKNYTLDKSAKCYAIGWGNIEQNEPYNIWSFEFDFVLERWRKNKSHKNSNILQEVEIPLV 551
NY + + CY GWG + K + +L+E ++P++
Sbjct: 689 -SNYMVADRSLCYITGWG-----------------------ETKGTYGAGLLKEAQLPVI 724
Query: 552 NFELCQK 572
++C +
Sbjct: 725 ENKVCNR 731
>sp|O46644|ELA1_MACFA Elastase-1 precursor
Length = 266
Score = 65.1 bits (157), Expect = 1e-10
Identities = 41/134 (30%), Positives = 65/134 (48%)
Frame = +3
Query: 39 YICGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDA 218
+ CGGTLI WV+TAAHC +D+ K F VV+ DH+ + +D
Sbjct: 54 HTCGGTLIRQNWVMTAAHC---------------VDSPK-----TFRVVVGDHNLSQNDG 93
Query: 219 DEISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVKNYTLDKS 398
E + +++P + ++ + YDIALL+L + V + V + +PQ + L
Sbjct: 94 TEQYVSVQKIVVHPYWNSNNVAAGYDIALLRLAQSVTLNSYVQLG--VLPQ-EGAILAND 150
Query: 399 AKCYAIGWGNIEQN 440
+ CY GWG + N
Sbjct: 151 SPCYITGWGRTKTN 164
>sp|P16296|FA9_RAT Coagulation factor IX (Christmas factor)
Length = 282
Score = 63.2 bits (152), Expect = 6e-10
Identities = 53/184 (28%), Positives = 76/184 (41%), Gaps = 2/184 (1%)
Frame = +3
Query: 45 CGGTLINPGWVVTAAHCLKTIEAVNSVPLGEMIDTRKYDLYDKFHVVINDHDRTTDDADE 224
CGG +IN W+VTAAHCLK DK VV +H+ + E
Sbjct: 81 CGGAIINEKWIVTAAHCLKP--------------------GDKIEVVAGEHNIDEKEDTE 120
Query: 225 ISRKLSYFIINPLFRADYSSNLYDIALLKLDKPVIPSKVVNINFPCVPQVKNYT--LDKS 398
R + I + + A + +DIALL+LDKP+I + V P K YT K
Sbjct: 121 QRRNVIRTIPHHQYNATINKYSHDIALLELDKPLILNSYVT---PICVANKEYTNIFLKF 177
Query: 399 AKCYAIGWGNIEQNEPYNIWSFEFDFVLERWRKNKSHKNSNILQEVEIPLVNFELCQKDI 578
Y GWG + NK + ++ILQ + +PLV+ C +
Sbjct: 178 GSGYVSGWGKV---------------------FNKG-RQASILQYLRVPLVDRATCLRST 215
Query: 579 EYLI 590
++ I
Sbjct: 216 KFSI 219
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,031,429
Number of Sequences: 369166
Number of extensions: 1470732
Number of successful extensions: 4567
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4171
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4354
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5169945420
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)